journal
MENU ▼
Read by QxMD icon Read
search

Current HIV Research

journal
https://www.readbyqxmd.com/read/29210661/impact-of-different-antiretroviral-strategies-on-total-hiv-dna-level-in-virologically-suppressed-hiv-1-infected-patients
#1
Isabella Bon, Leonardo Calza, Giuseppina Musumeci, Serena Longo, Alessia Bertoldi, Vanessa D'Urbano, Davide Gibellini, Eleonora Magistrelli, Pier Luigi Viale, Maria Carla Re
Background Total HIV-DNA load in peripheral blood cell (PBMCs) reflects the global viral reservoir that seems to be not affect by antiretroviral treatment. However, some studies reported a different permeability of different drugs in cellular compartments. Objective To investigate the relation between the amount of total HIV-1 DNA and different treatment strategies. Method Total HIV-1 DNA was quantified by real time PCR in PBMCs collected from 161 patients with long-term undetectable HIV-RNA receiving different therapy schedules (3-drug regimens or 2-drug regimen containing Raltegravir as integrase inhibitor)...
December 6, 2017: Current HIV Research
https://www.readbyqxmd.com/read/29210660/host-factors-predictors-in-long-term-nonprogressors-hiv-1-infected-with-distinct-viral-clades
#2
J S Santos, S M Almeida, G F Silveira, J Bordignon, S Lm Teixeira, Acm Lima, S M Raboni
BACKGROUND: HIV-1+ long-term non-progressors (LTNPs) maintain natural control of viral infection. This study sought to identify and characterize HIV- LTNPs series case, regarding the presence of possible host factors that may be associated with this status. METHODS: We evaluated the plasma levels of IP-10/IL-8 chemokines, HLA-B alleles, and IL28B rs12979860 polymorphism in 24 LTNPs who presented with infection by different clades of HIV-1. RESULTS: IL-8 chemokine was significantly higher in progressors than in LTNPs, but there was no difference between the LTNP subgroups...
December 6, 2017: Current HIV Research
https://www.readbyqxmd.com/read/29173180/the-neutralizing-antibody-response-to-the-hiv-1-env-protein
#3
Penny L Moore
BACKGROUND: A vaccine able to elicit broadly neutralizing antibodies capable of blocking infection by global viruses has not been achieved, and remains a key public health challenge. OBJECTIVE: During infection, a robust strain-specific neutralizing response develops in most people, but only a subset of infected people develop broadly neutralizing antibodies. Understanding how and why these broadly neutralizing antibodies develop has been a focus of the HIV-1 vaccine field for many years, and has generated extraordinary insights into the neutralizing response to HIV-1 infection...
November 24, 2017: Current HIV Research
https://www.readbyqxmd.com/read/29173179/siv-coreceptor-specificity-in-natural-and-non-natural-host-infection-implications-for-cell-targeting-and-differential-outcomes-from-infection
#4
Katherine S Wetzel, Sarah T C Elliott, Ronald G Collman
Pathogenic HIV-1 infection of humans and SIVmac infection of macaques are the result of zoonotic transfer of primate immunodeficiency viruses from their natural hosts into non-natural host species. Natural host infections do not result in pathogenesis despite high levels of virus replication, and evidence suggests that differences in anatomical location and specific subsets of CD4+ T cells infected may underlie distinct outcomes from infection. The coreceptor CCR5 has long been considered the sole pathway for SIV entry and the key determinant of CD4+ cell targeting, but it has also been known that natural hosts express exceedingly low levels of CCR5 despite maintaining high levels of virus replication...
November 24, 2017: Current HIV Research
https://www.readbyqxmd.com/read/29173176/the-siv-envelope-glycoprotein-viral-tropism-and-pathogenesis-novel-insights-from-nonhuman-primate-models-of-aids
#5
Adrienne E Swanstrom, Gregory Q Del Prete, Claire Deleage, Samra E Elser, Andrew A Lackner, James A Hoxie
BACKGROUND: Cellular tropism of human immunodeficiency virus (HIV-1) is closely linked to interactions between the viral envelope glycoprotein (Env) with CD4 and chemokine receptor family members, CCR5 and CXCR4. This interaction plays a key role in determining anatomic sites that are infected in vivo and the cascade of early and late events that result in chronic immune activation, immunosuppression and ultimately, AIDS. CD4+ T cells are critical to adaptive immune responses, and their early and rapid infection in gut lamina propria and secondary lymphoid tissues in susceptible hosts likely contributes to viral persistence and progression to disease...
November 24, 2017: Current HIV Research
https://www.readbyqxmd.com/read/29173178/knowledge-normative-beliefs-and-attitudes-related-to-recent-hiv-infection-among-people-who-inject-drugs-in-athens-greece
#6
Foteini Giannou, Georgios K Nikolopoulos, Katerina Pantavou, Vassiliki Benetou, Maria Kantzanou, Vana Sypsa, Leslie D Williams, Samuel R Friedman, Angelos Hatzakis
Background Despite great improvements in prevention over the last years, much has to be done to reduce new human immunodeficiency virus (HIV) infections. Substantial evidence shows that the six-month period of recent HIV infection contributes disproportionately to HIV transmission. Objective This study aims to investigate knowledge, normative beliefs, and attitudes of people who inject drugs (PWID) regarding recent HIV infection. Method People who inject drugs in Athens, Greece were recruited in the fifth round of a respondent-driven sampling program (ARISTOTLE)...
November 22, 2017: Current HIV Research
https://www.readbyqxmd.com/read/29173177/integrase-strand-transfer-inhibitors-and-the-emergence-of-immune-reconstitution-inflammatory-syndrome-iris
#7
Mina Psichogiou, Dimitrios Basoulis, Maria Tsikala-Vafea, Stefanos Vlachos, Christos J Kapelios, Georgios L Daikos
BACKGROUND: Immune reconstitution inflammatory syndrome (IRIS) is a major concern when starting highly active anti-retroviral therapy (HAART) in new patients and especially late presenters. This study attempts to identify risk factors for IRIS and investigate whether certain treatment regimens increase the probability of IRIS for patients at risk. METHODS: Retrospective single-centre study of HIV patients treated with HAART. RESULTS: A total of 417 patients were included...
November 22, 2017: Current HIV Research
https://www.readbyqxmd.com/read/29165088/detailed-molecular-surveillance-of-the-hiv-1-outbreak-among-people-who-inject-drugs-pwid-in-athens-during-a-period-of-four-years
#8
Evangelia Kostaki, Gkikas Magiorkinis, Mina Psichogiou, Andreas Flampouris, Panos Iliopoulos, Eleni Papachristou, Georgios L Daikos, Stefanos Bonovas, Dan Otelea, Samuel R Friedman, Angelos Hatzakis, Dimitrios Paraskevis
BACKGROUND: New diagnoses of HIV-1 infection among people who inject drugs (PWID) increased significantly during 2011 in Athens. OBJECTIVE: Our aim was to investigate the patterns of HIV epidemic spread among PWID and to estimate the transmission dynamics for the major local transmission networks (LTNs). METHOD: We analyzed sequences from 2,274 HIV-infected subjects sampled in Greece during 01/01/2011-31/10/2014. Of specimens in our sample, 874 sequences were isolated from HIV-infected PWID...
November 19, 2017: Current HIV Research
https://www.readbyqxmd.com/read/29165087/nucleotide-reverse-transcriptase-inhibitors-a-thorough-review-present-status-and-future-perspective-as-hiv-therapeutics
#9
Ashley D Holec, Subhra Mandal, Pavan Kumar Prathipati, Christopher J Destache
Human immunodeficiency virus type-1 (HIV-1) infection leads to acquired immunodeficiency syndrome (AIDS), a severe fatal viral infection that has claimed approximately 658,507 lives in the US within the year 2010-2014. Antiretroviral (ARV) therapy has proven to inhibit HIV-1, but unlike other viral illness, not cure the infection. Among various Food and Drug Administration (FDA)-approved ARVs, nucleoside/nucleotide reverse transcriptase inhibitors (NRTIs) are most effective in limiting HIV-1 infection. This review focuses on NRTIs mechanism of action and metabolism...
November 19, 2017: Current HIV Research
https://www.readbyqxmd.com/read/29165086/association-between-ltf-polymorphism-and-risk-of-hiv-1-transmission-among-zambian-seropositive-mothers
#10
Luisa Zupin, Vania Polesello, Ludovica Segat, Anselmo Jiro Kamada, Louise Kuhn, Sergio Crovella
BACKGROUND: Lactoferrin is a member of the innate immune system acting in the first line of defence against pathogens, and it is known for its antibacterial, antifungal and antiviral activity, including HIV-1. Two polymorphisms, T29A and R47K, in the exon 1 region of the LTF gene (encoding for the lactoferrin protein) were previously described as able to influence the lactoferrin antimicrobial function. OBJECTIVES: LTF T29A and R47K genetic variants were analysed in a Zambian population to unravel if these polymorphisms could play a role in HIV-1 mother-to-child HIV-1 transmission...
November 19, 2017: Current HIV Research
https://www.readbyqxmd.com/read/29119934/direct-acting-antivirals-for-hiv-hcv-co-infected-individuals-as-good-as-it-gets
#11
Giuseppe Bruno, Annalisa Saracino
Although HIV/HCV co-infected individuals were historically considered a "difficult to treat" population in the era of Interferon (IFN)-based anti-HCV treatment, the introduction of direct-acting antivirals, characterized by excellent efficacy and good safety profile, has widely revolutionized the HCV treatment scenario. Recent real life studies reported excellent sustained virological response rates in HIV/HCV co-infected subjects, thus confirming data obtained in randomized clinical trials. However, certain issues have recently emerged in this population...
November 8, 2017: Current HIV Research
https://www.readbyqxmd.com/read/29046160/construction-and-production-of-hiv-vlp-harboring-mper-v3-for-potential-vaccine-study
#12
Fatemeh Tohidi, Seyed Mehdi Sadat, Azam Bolhassani, Ramin Yaghobi
Vaccine against HIV-1 is not currently available. In present, Virus like particles (VLPs) as effective strategy was used in several vaccine developing. Two conserved sequences; V3 loop of gp120 and the membrane-proximal external region (MPER) of gp41 are dominant sites for vaccine studies. In this study, we used fusion gene of MPER and V3 to product recombinant VLPs and introduced a novel retroviral VLPs harboring high copy of MPER-V3 for HIV-1 vaccine design. The pEGFP-N1 plasmid harboring MPER-V3 sequence with Vpr linker was constructed...
October 17, 2017: Current HIV Research
https://www.readbyqxmd.com/read/29046159/pilot-integration-of-hiv-screening-and-healthcare-settings-with-multi-component-social-network-and-partner-testing-for-hiv-detection
#13
Michael F Rentz, Andrew H Ruffner, Rachel M Ancona, Kimberly W Hart, John R Kues, Christopher M Barczak, Christopher J Lindsell, Carl J Fichtenbaum, Michael S Lyons
BACKGROUND: Healthcare settings screen broadly for HIV. Public health settings use social network and partner testing ("Transmission Network Targeting (TNT)") to select high-risk individuals based on their contacts. HIV screening and TNT systems are not integrated, and healthcare settings have not implemented TNT. OBJECTIVE: To evaluate pilot implementation of multi-component, multi-venue TNT in conjunction with HIV screening by a healthcare setting. METHODS: Our urban, academic health center implemented a TNT program in collaboration with the local health department for five months during 2011...
October 17, 2017: Current HIV Research
https://www.readbyqxmd.com/read/28990535/voluntary-medical-male-circumcision-to-prevent-hiv-in-tanah-papua-indonesia-field-trial-to-assess-acceptability-and-feasibility
#14
M Ridwan Ansari, Elan Lazuardi, Frank Stephen Wignall, Constant Karma, Sylvanus A Sumule, Siti Nadia, Robert Magnani
BACKGROUND: Relatively little attention has been directed to the significant HIV prevention role that voluntary medical male circumcision (VMMC) can play in populations with moderate levels of HIV prevalence. One such location is Tanah Papua, Indonesia, which in 2013 had a general population HIV prevalence of 2.3% concentrated among indigenous Papuans (2.9% prevalence), very few of whom are circumcised. This article reports the findings of an implementation research study assessing the acceptability and feasibility of introducing VMMC for HIV prevention...
October 5, 2017: Current HIV Research
https://www.readbyqxmd.com/read/28990534/association-between-vitamin-d-status-oxidative-stress-biomarkers-and-viral-load-in-human-immunodeficiency-virus-type-1-infection
#15
Tamires Flauzino, Andréa Nc Simão, Elaine Rd de Almeida, Helena K Morimoto, Sayonara R Oliveira, Daniela F Alfieri, Luiz T Ueda, Isaias Dichi, Edna Mv Reiche
BACKGROUND: The role of vitamin D in the pathophysiology of human immunodeficiency virus type 1 (HIV-1) infection is still unclear. OBJECTIVE: To evaluate the associations between vitamin D and immunological, virological, and oxidative stress biomarkers in individuals with human immunodeficiency virus type 1 (HIV-1) infection. METHODS: The serum levels of 25 hydroxyvitamin D [25(OH)D] were determined in 314 HIV-1-infected individuals and 127 controls and the values ≥30 ng/mL defined a vitamin D sufficient (VDS) status, and <30 ng/mL defined as hypovitaminosis D (HD)...
October 5, 2017: Current HIV Research
https://www.readbyqxmd.com/read/28969557/impact-of-high-protein-intake-on-viral-load-and-hematological-parameters-in-hiv-infected-patients
#16
Evgeny Vlad Butorov
BACKGROUND: The impact of protein intake level leads to considerable alterations of the host essential amino acid profiles in the context of chronic viral infectious process. Amino acids play an important role in the pathogenesis of virus-related infections both as basic substrates for constant protein synthesis and as regulators in many metabolic pathways. The excess or deficiency of these host essential nutritional elements can play a limiting role in the life cycle of some viruses...
October 2, 2017: Current HIV Research
https://www.readbyqxmd.com/read/28969567/long-term-treatment-with-raltegravir-is-associated-with-lowering-triglycerides-and-platelets-count-in-the-older-hiv-population-results-from-the-ral-age-study
#17
Paolo Pavone, Noemi Giustini, Caterina Fimiani, Francesca Paoletti, Mario Falciano, Alessandra Salotti, Fiorella Di Sora, Samir Al Moghazi, Ivano Mezzaroma, Vincenzo Vullo, Gabriella D'Ettorre
BACKGROUND: Raltegravir (RAL) is considered one of the better-tolerated antiretroviral medications, due to limited side effects and minimal drug-drug interactions. Matherials and Methods: We retrospectively evaluated 96 HIV+, over 60 years old, experienced patients who had switched from any antiretroviral drug to raltegravir-based nuc-sparing or standard nucleoside-backbone regimens. RESULTS: The median age of the patients was 66 years (IQR 10.5) (77 M, 19 F); the median time horizon of follow-up was 4 years (IQR 5)...
September 27, 2017: Current HIV Research
https://www.readbyqxmd.com/read/28933280/prevalence-of-hiv-seropositivity-and-associated-impact-on-mortality-among-injured-patients-from-low-and-middle-income-countries-a-systematic-review-and-meta-analysis
#18
Adam R Aluisio, Soham Rege, Barclay T Stewart, John Kinuthia, Adam C Levine, Michael J Mello, Carey Farquhar
BACKGROUND: Although HIV and injury contribute substantially to disease burdens in low-and middle-income countries (LMIC), their intersection is poorly characterized. OBJECTIVE: This systematic review assessed the prevalence and associated mortality impact of HIV-seropositivity among injured patients in LMIC. METHODS: A systematic search of PubMed, EMBASE, Global Health, CINAHL, POPLINE and Cochrane databases through August 2016 was performed...
September 19, 2017: Current HIV Research
https://www.readbyqxmd.com/read/29197320/erratum
#19
(no author information available yet)
No abstract text is available yet for this article.
November 23, 2017: Current HIV Research
https://www.readbyqxmd.com/read/28820066/mutational-impact-on-the-interaction-between-human-il27-and-gp130-in-silico-approach-for-defending-hiv-infection
#20
Arundhati Banerjee, Rakhi Dasgupta, Sujay Ray
INTRODUCTION: With advances in proteomics, it is essential to investigate the molecular-level participation of IL27 and gp130 to hinder HIV infection. Their interaction causes cell-cycle arrest in HIV+ cells by activating the receptor-associated JAK signaling and causing apoptosis of cancerous cells. METHODOLOGY: The best human wild-type WT_IL27 model was prepared after varied molecular modeling techniques. The vital tyrosine residues in WT_IL27 were identified, mutated and IL27 was re-modeled...
August 17, 2017: Current HIV Research
journal
journal
40306
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"