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Journal of Integrative Neuroscience

Hongbin Liu, Yongjun Huang, Jinyi Li
Parkinson's disease is one of the most common diseases in the elderly population, and the substantia nigra is generally involved in the disease process; however, the signaling pathways and related genes underlying Parkinson's disease remain unclear. This study integrated three cohorts of profile datasets to elucidate the potential key candidate genes and pathways in Parkinson's disease. The expression profiles of GSE8397, GSE20186 and GSE49036 were included 55 available substantia nigra tissue samples from individuals diagnosed with Parkinson's disease and 33 substantia nigra tissue samples from healthy controls...
July 13, 2018: Journal of Integrative Neuroscience
Badrah Saeed Ali Alghamdi
Alzheimer's disease (AD) is a progressive neurodegenerative disease that affects an estimated 5.4 million people worldwide. However, there remains no curative treatment for the condition. Aβ and hyperphosphorylated tau accumulation are the main hallmarks of the disease; they interfere with glutamate uptake and mediate glutamate excitotoxicity, oxidative stress, inflammation and neurodegeneration. As virgin coconut oil (VCO) is well-known as an antioxidant and anti-inflammatory natural compound, the purpose of the present study was to assess the possible prophylactic effect of VCO on aluminium chloride (AlCl3)- induced AD in rat...
July 13, 2018: Journal of Integrative Neuroscience
Sara Motamed, Saeed Setayeshi, Azam Rabiee
Speech emotion recognition is a challenging obstacle to enabling communication between humans and machines. The present study introduces a new model of speech emotion recognition based on the relationship between the human brain and mind. According to this relationship, the proposed model consists of two parts: the brain short term memory (BSTM) and mind long term memory (MLTM). The input of the BSTM is emotional speech signals. Then, this part gives one copy of information to the MLTM. The reason is that the brain needs to save information as knowledge in a bigger and safer place similar to the human mind...
July 10, 2018: Journal of Integrative Neuroscience
A M Elaiw, N H AlShamrani
In this paper we propose and analyze a pathogen dynamics model with antibody and Cytotoxic T Lymphocyte (CTL) immune responses. We incorporate latently infected cells and three distributed time delays into the model. We show that the solutions of the proposed model are nonnegative and ultimately bounded. We derive four threshold parameters which fully determine the existence and stability of the five steady states of the model. Using Lyapunov functionals, we established the global stability of the steady states of the model...
April 27, 2018: Journal of Integrative Neuroscience
A A Alderremy, S Saleem, F A Hendi
In this work, a comparative study of seven well-known mathematical techniques for the coupled Burgers' equations is reported. The techniques involve in this comparison are as follows: Laplace transform Adomian decomposition method, Laplace transform homotopy perturbation method, Variational iteration method, Variational iteration decomposition method, Variational iteration homotopy perturbation method, the optimal homotopy asymptotic method, and OHAM with Daftardar-Jafari polynomial. Here we considered a practical example which consists of coupled Burgers' equations with the kinematic viscosity ε=1...
April 27, 2018: Journal of Integrative Neuroscience
H B Santhosh, C S K Raju
This study explores the magneto hydrodynamic Carreau fluid in the interruption of titanium alloy nanoparticles with heat generation and porosity. The simulation is performed by combination of titanium alloy nanoparticles into base water. Titanium is strong and light in weight and sit is used in military and aerospace, in bio science it is used as anti-microbial, anti-biotic, and anti-fungal agents. The arising set of partial differential equations (P.D.E) are converted into set of ordinary differential equation (O...
April 27, 2018: Journal of Integrative Neuroscience
Muhammad Saleem, Kashif Sharif, Aliya Fahmi
Applications of Pareto distribution are common in reliability, survival and financial studies. In this paper, A Pareto mixture distribution is considered to model a heterogeneous population comprising of two subgroups. Each of two subgroups is characterized by the same functional form with unknown distinct shape and scale parameters. Bayes estimators have been derived using flat and conjugate priors using squared error loss function. Standard errors have also been derived for the Bayes estimators. An interesting feature of this study is the preparation of components of Fisher Information matrix...
April 27, 2018: Journal of Integrative Neuroscience
N Sandeep, G Kumaran, S Saleem
The flow of magnetohydrodynamic Carreau liquid with the Brownian moment, thermophoresis and cross diffusion effects is investigated numerically. The buoyancy persuades on the flow is contemplated in such a way that the surface is neither perpendicular/horizontal nor wedge/cone. This is very helpful in the design of jet-engine. The equations govern the flow are transmuted using acceptable similarity variables and numerically solved by recruiting Runge-Kutta based Newtons method. The graphical results are obtained to discuss the stimulus of flow, thermal and concentration fields for different parameters of interest...
April 26, 2018: Journal of Integrative Neuroscience
Yuepeng Wu, Meihua Chen, Yu Cui, Xiying He, Jingzhong Niu, Yanbo Zhang, Li Zhou
OBJECTIVE: Our aim was to study the character of quantitative EEG of viral encephalitis. METHOD: Collect the EEG data of hospitalized children with viral encephalitis diagnosed by pediatricians from January 2013 to September 2016, and EEG data of normal cases at the same age were control group. Using quantitative EEG analysis technologies to obtain power spectrum value, power spectrum value, 1 power spectrum value, 12 power spectrum value, 21 power spectrum value, and 12 power spectrum value...
April 26, 2018: Journal of Integrative Neuroscience
Renata S Marcomini, Ana Claúdia F Frizzo, Viviane B de Góes, Simone F Regaçone, David M Garner, Rodrigo D Raimundo, Fernando R Oliveira, Vitor E Valenti
Sound signal processing signifies an important factor for human conscious communication and it may be assessed through cortical auditory evoked potentials (CAEP). Heart rate variability (HRV) provides information about heart rate autonomic regulation. We investigated the association between resting HRV and CAEP. We evaluated resting HRV in the time and frequency domain and the CAEP components. The subjects remained at rest for 10 minutes for HRV recording, then they performed the CAEP examinations through frequency and duration protocols in both ears...
April 26, 2018: Journal of Integrative Neuroscience
Elham Askari, Seyed Kamaledin Setarehdan, Ali Sheikhani, Mohammad Reza Mohammadi, Mohammad Teshnehlab
In neuropsychological disorders, the significant abnormalities in the brain connections in some regions are observed. This paper presents a novel model to demonstrate the connections between different regions in children with autism. The proposed model first conducts the wavelet decomposition of electroencephalography signals by wavelet transform then the features are extracted, such as relative energy and entropy. These features are fed to the 3D-cellular neural network model as inputs to indicate the brain connections...
April 20, 2018: Journal of Integrative Neuroscience
A Kotini, T Birbilis, P Anninos, I Seimenis
A 82-year-old male experiencing headaches, dementia, urinary incontinence and gait instability was diagnosed with normal pressure hydrocephalus (NPH) and underwent a resting state magnetoencephalography (MEG) examination. MEG data were recorded in a magnetically shielded room with a whole-head 122 channel biomagnetometer. Following MEG, a ventriculoperitoneal (VP) shunt was placed in his head and greatly improved his symptomatology. Spontaneous MEG recordings revealed lower magnetic fields at frontal and frontotemporal regions compared to central and posterior regions...
April 18, 2018: Journal of Integrative Neuroscience
Iqtadar Hussain, Amir Anees, Abdulmohsen Algarni
Thermal images play a vital character at nuclear plants, Power stations, Forensic labs biological research, and petroleum products extraction. Safety of thermal images is very important. Image data has some unique features such as intensity, contrast, homogeneity, entropy and correlation among pixels that is why somehow image encryption is trickier as compare to other encryptions. With conventional image encryption schemes it is normally hard to handle these features. Therefore, cryptographers have paid attention to some attractive properties of the chaotic maps such as randomness and sensitivity to build up novel cryptosystems...
April 16, 2018: Journal of Integrative Neuroscience
Qing-Lin Zhang, Ming-Jun Xu, Tian-Long Wang, Zi-Qiong Zhu, Fancai Lai, Xiao-Chun Zheng
To investigate the relationship between acetyl cholinesterase associated collagen gene (COLQ) mutation in patients with acetyl cholinesterase deficiency and its clinical characteristics. Serum and red blood cell acetyl cholinesterase from patients with acetyl cholinesterase deficiency (n=6) and normal controls (n=20) were measured by butyryl thiocholine substrate. COLQ gene variations were detected by sequencing. And the cholinesterase (ChE) genotypes were measured by dibucaine inhibition in vitro. The distributions of ChE surrounded the blood vessels and nerve fibers in lung or pancreas tissues were detected by immunohistochemical staining and indirect immunofluorescence...
April 3, 2018: Journal of Integrative Neuroscience
V Priya, B N Srikumar, B S Shankaranarayana Rao
Performing multiple tasks either simultaneously, in rapid alternation or in succession, is routine in daily life. Further, testing rodents in a battery of tests is common both in drug discovery and behavioral phenotyping research. However, learning of new tasks can be influenced by prior experience(s). There has been some research on 'switching cost' involved in the transition from one behavior to another. However, there has been no specific assessment of the effect of learning an operant paradigm on performance in a spatial memory task and vice versa...
March 12, 2018: Journal of Integrative Neuroscience
J Meléndez-Gallardo, A Eblen-Zajjur
Despite the frequent clinical hyper- or hypothermia cases, thermal-dependence of the endogenous pain modulation system at the spinal cord is not well understood. We evaluate spinal dorsal horn neuronal network responses during mechanical heterotopic noxious stimuli (HNS) at three different body temperatures (34; 37 or 40°C) by measuring lumbar cord dorsum potentials activated by electrical stimulation of the ipsilateral sural nerve in adult thiopental anesthetized rats. A noxious clamp was applied randomly to the tail, right hindpaw, right forepaw, muzzle and left forepaw...
March 12, 2018: Journal of Integrative Neuroscience
Lei Guo, Wei Zhang, Jialei Zhang
A ten-layer feed forward network is constructed in the presence of an exogenous alternating magnetic field. Specifically, our results indicate that for rate coding, the firing rate is significantly increased in the presence of an exogenous alternating magnetic field and particularly with increasing enhancement of the alternating magnetic field amplitude. For temporal coding, the interspike intervals of the spiking sequence are decreased and the distribution of the interspike intervals of the spiking sequence tends to be uniform in the presence of alternating magnetic field...
2018: Journal of Integrative Neuroscience
Zahra Khayyer, Leonard Ngaosuvan, Sverker Sikström, Amir Hossein Ghaderi
Frontal cortex activity in the left hemisphere during depression is reduced. Transcranial direct current stimulation (tDCS) is a non-invasive neuromodulation technique that can increase frontal cortex activity. Therapy based on tDCS and positive psychology (PP) therapy was applied improving patients' quality of life. The present study compared three conditions participants with clinical depression; (a) tDCS therapy, (b) positive psychotherapy, and (c) combined treatment. Hamilton Depression Rating Scale (HDRS), Adult State Hope Scale and Optimism/Pessimism Scale (OPS) was used at baseline, 2 weeks, 4-weeks and 3-months follow-up...
2018: Journal of Integrative Neuroscience
Ivan Grbatinić, Nebojsa Milosevic, Dusica Maric
The aim of this study is to determine whether the dentate neurons can be translaminary neuromorphotopologically classified as ventrolateral or dorsomedial type. Adult human dentate 2D binary interneuron images are used for the purposes of the analysis. The analysis is performed on the real and the virtual neuron sample. The total of 29 parameters is used. They can be divided into the classes: neuron surface, shape, length, branching and complexity. The clustering is performed through the algorithm consisted from of the steps of predictor extraction (matrix attractor analysis/non-negative matrix factorization and cluster analysis of predictor factors, separate unifactor analysis/Student's t-test and MANOVA) and multivariate cluster analysis set (cluster analysis, principal component analysis, factor analysis with pro/varimax rotation, Fisher's linear discriminant analysis and feed-forward backpropagation artificial neural networks)...
2018: Journal of Integrative Neuroscience
Hua Zhou, Yan Tang, Zhi Yuan
White matter (WM) asymmetries of the human brain have been well documented using diffusion tensor imaging (DTI). The purpose of this study was to investigate white matter asymmetry across the whole brain in cerebral small vessel disease (SVD) patients and evaluate the relation between the factors which often represent disease's existence and white matter asymmetry. A total of 105 nondemented elderly with cerebral SVD patients aged between 60 and 85 years were included in this study. All participants underwent T1 MPRAGE, fluid-attenuated inversion recovery and DTI scanning...
2018: Journal of Integrative Neuroscience
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