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Ocular Surface

Vikram Paranjpe, Jeremy Tan, Jason Nguyen, John Lee, Jeremy Allegood, Anat Galor, Nawajes Mandal
PURPOSE: Sphingolipids (SPL) play roles in cell signaling, inflammation, and apoptosis. Changes in SPL composition have been reported in individuals with MGD, but associations between clinical signs of MGD and compositional changes in meibum SPLs have not been examined. METHODS: Forty-three individuals underwent a tear film assessment. Groups were split into those with good or poor quality meibum. Meibum was collected then analyzed with liquid chromatography-mass spectroscopy to quantify SPL classes...
December 12, 2018: Ocular Surface
Douglas Borchman, Aparna Ramasubramanian
NMR spectroscopy was used to measure hydrocarbon chain branching variability in meibum with age, gender and Meibomian gland dysfuction (MGD). A cohort of 65 meibum donors without dry eye and 31 donors with MGD was studied. Heteronuclear 2D NMR was used to confirm CH3 resonance assignments allowing us to positively identify 23 of the 27 proton resonances of cholesteryl ester and 1 H resonances due to straight chain, iso-branched and anteiso-branched hydrocarbons. Meibum from donors without dry eye contained 57 ± 1% straight-chains, 23 ± 1% iso-branched chains and 20 ± 1% anteiso-branched hydrocarbon chains...
December 12, 2018: Ocular Surface
Ali R Djalilian
No abstract text is available yet for this article.
December 11, 2018: Ocular Surface
Sayena Jabbehdari, Taylor W Starnes, Khaliq H Kurji, Medi Eslani, Maria S Cortina, Edward J Holland, Ali R Djalilian
AIM & OBJECTIVE: Severe ocular surface disease, including limbal stem cell deficiency (LSCD) can occur as a consequence of severe atopic keratoconjunctivitis (AKC) that has been inadequately treated. Our goal was to describe the management and outcomes of severe ocular surface disease in AKC patients. METHODS: We performed a retrospective analysis of a case series of 13 eyes of 8 patients with advanced ocular surface disease associated with severe AKC. The clinical presentation, medical and surgical management, and visual and anatomic outcomes were analyzed...
December 4, 2018: Ocular Surface
Yang Liu, Di Chen, Xiaomin Chen, Wendy R Kam, Mark P Hatton, David A Sullivan
PURPOSE: Optimal meibomian gland (MG) function is critically important for the health and wellbeing of the ocular surface. We hypothesize that low oxygen (O2 ) conditions promote the function of human MG epithelial cells (HMGECs) and that human MGs exist in a relatively hypoxic environment. The purpose of this study was to test our hypotheses. METHODS: We used human and mouse eyelid segments, and immortalized human MG epithelial cells (IHMGECs) in our studies. To evaluate oxygen (O2 ) levels in the mouse MG and vicinity, we injected pimonidazole (pimo), a hypoxia marker, before sacrifice...
December 4, 2018: Ocular Surface
John D Sheppard, Gail L Torkildsen, Joel A Geffin, Jung Dao, David G Evans, George W Ousler, Jasmine Wilson, Stephanie N Baba, Michelle Senchyna, Edward J Holland
PURPOSE: The intranasal tear neurostimulator (ITN) activates the nasolacrimal pathway, which is involved with basal and bolus tear secretion. These studies characterized the acute and long-term effectiveness of the ITN in stimulating tear production in subjects with dry eye disease (DED). METHODS: Study 1: Randomized, double-masked, dual-controlled, 1-day crossover. Study 2: Single-arm, open-label, 180-day prospective cohort. Eligible subjects had basal unstimulated Schirmer test (with anesthesia) ≤10 mm and intranasal cotton swab-stimulated Schirmer test at least 7 mm greater in the same eye, and Ocular Surface Disease Index® ≥13 and ≥ 23, in Studies 1 and 2, respectively...
November 22, 2018: Ocular Surface
Jia Yin, Deborah S Jacobs
PURPOSE: To report the long-term outcome of Prosthetic Replacement of the Ocular Surface Ecosystem (PROSE) for delivery of bevacizumab in the treatment of corneal neovascularization (KNV). METHODS: Retrospective, non-comparative, interventional case series of 13 sequential patients treated for KNV at the BostonSight between 2006 and 2017. In all cases, PROSE treatment was initiated for management of ocular surface disease and patients wore PROSE consistently on a daily wear basis prior to bevacizumab treatment...
November 20, 2018: Ocular Surface
Soh R, Tong L
No abstract text is available yet for this article.
November 17, 2018: Ocular Surface
Jerome Ozkan, Mark Willcox, Bernd Wemheuer, Geoff Wilcsek, Minas Coroneo, Torsten Thomas
PURPOSE: The human eye is composed of numerous microhabitats. The aim of this study was to understand the communality and differences in the microbiomes of various regions of the eye. METHODS: Four ocular sites from different subject groups were assessed including the eyelid margin tissue from patients with lid abnormalities (n = 20), fornix and limbus conjunctival tissue from patients with pterygia (n = 23), ocular (conjunctival) surface swabs (n = 45) and facial skin swabs (n = 16)...
November 13, 2018: Ocular Surface
Reiko Arita, Shima Fukuoka, Naoyuki Morishige
PURPOSE: To evaluate the efficacy and safety of intense pulsed light (IPL) combined with meibomian gland expression (MGX) for treatment of refractory meibomian gland dysfunction (MGD). METHODS: Ninety eyes of 45 patients were randomly assigned to receive either the combination of IPL and MGX or MGX alone (control). Each eye underwent eight treatment sessions at 3-week intervals. Parameters were evaluated before and during treatment as well as at 3-11 weeks after the last treatment session...
November 13, 2018: Ocular Surface
Matteo M E Metruccio, Stephanie J Wan, Hart Horneman, Abby R Kroken, Aaron B Sullivan, Tan N Truong, James J Mun, Connie K P Tam, Robin Frith, Laurence Welsh, Melanie D George, Carol A Morris, David J Evans, Suzanne M J Fleiszig
PURPOSE: Contact lens wear carries a risk of complications, including corneal infection. Solving these complications has been hindered by limitations of existing animal models. Here, we report development of a new murine model of contact lens wear. METHODS: C57BL/6 mice were fitted with custom-made silicone-hydrogel contact lenses with or without prior inoculation with Pseudomonas aeruginosa (PAO1-GFP). Contralateral eyes served as controls. Corneas were monitored for pathology, and examined ex vivo using high-magnification, time-lapse imaging...
November 12, 2018: Ocular Surface
Gabriela Dieckmann, Felipe Fregni, Pedram Hamrah
Neuromodulation is a novel approach that utilizes electrical signals, pharmaceutical agents, or other forms of energy to modulate abnormal neural function through neurostimulation. Neurostimulation is a novel technique that uses electrical currents to stimulate the nervous system. During the recent few decades, neuromodulation has gained significant attention, in particular for the treatment of chronic neurological diseases, due to its success in treating patients unresponsive to conventional pharmacological therapies...
November 9, 2018: Ocular Surface
José A P Gomes, Ruth M Santo
Several aspects of the quality of life (QoL) and treatment satisfaction of patients with dry eye disease (DED) may be underestimated. Ocular symptoms, which are assessed by validated patient-reported questionnaires and may include stinging, burning, itchiness, grittiness, dryness and discomfort, reduce QoL by affecting daily activities and work productivity. Self-reported symptoms do not always correlate with post-treatment improvements in clinical measures such as tear film break-up time, inflammation and osmolarity...
November 9, 2018: Ocular Surface
Hideki Sonobe, Yoko Ogawa, Kentaro Yamada, Eisuke Shimizu, Yuichi Uchino, Mizuka Kamoi, Yumiko Saijo, Mio Yamane, Daniel Citterio, Koji Suzuki, Kazuo Tsubota
PURPOSE: To elucidate the correlation between lactoferrin concentration in the tear film and signs and symptoms of severe dry eye disease (DED) using a novel microfluidic paper-based analytical device (μPAD) and enzyme-linked immunosorbent assay (ELISA). METHODS: Twenty-four patients were recruited at the Keio University Hospital. Using a novel μPAD, lactoferrin concentrations were measured in 4 patients with GVHD-related DED, 3 patients with other type of dry eye and 2 controls (Group A)...
November 3, 2018: Ocular Surface
Mehran Zarei-Ghanavati, Paolo Rama, Christopher Liu
No abstract text is available yet for this article.
October 17, 2018: Ocular Surface
Giuseppe Giannaccare, Federico Bernabei, Marco Pellegrini, Mario Arpinati, Francesca Bonifazi, Mariarosaria Sessa, Piera Versura, Emilio Campos
PURPOSE: To assess eyelid metrics in the setting of chronic ocular graft versus-host disease (oGVHD), and to further correlate them with hematological and ocular characteristics. METHODS: Prospective case-control study conducted at a single tertiary-referred Center. The following eyelid tests were performed in oGVHD patients and control subjects: vertical lid pull; anterior/lower distraction; lateral/medial distraction; distance between lateral canthal angle and orbital rim; margin reflex distances (MRD) 1 and 2; duration of tarsus exposure; snap back...
October 12, 2018: Ocular Surface
Anne Gad, Algis Jonas Vingrys, Chinn Yi Wong, David Charles Jackson, Laura Elizabeth Downie
PURPOSE: To investigate the ocular inflammatory response, using clinical and immunological techniques, in people experiencing contact lens (CL) discomfort. METHODS: This study involved 38 adults who were full-time, silicone-hydrogel CL wearers. Participants were categorized into groups based upon a validated CL dry-eye questionnaire (CLDEQ-8) (n = 17 'asymptomatic', CLDEQ-8 score <9; n = 21 'symptomatic', CLDEQ-8 score ≥13). Examinations were performed at two visits (one with, and one without, CL wear), separated by one-week...
October 12, 2018: Ocular Surface
G A R Y D Novack
No abstract text is available yet for this article.
October 11, 2018: Ocular Surface
Ann-Marie Lobo, Alex M Agelidis, Deepak Shukla
Herpes simplex virus type 1 (HSV) keratitis is a leading cause of infectious blindness. Clinical disease occurs variably throughout the cornea from epithelium to endothelium and recurrent HSV stromal keratitis is associated with corneal scarring and neovascularization. HSV keratitis can be associated with ocular pain and subsequent neutrophic keratopathy. Host cell interactions with HSV trigger an inflammatory cascade responsible not only for clearance of virus but also for progressive corneal opacification due to inflammatory cell infiltrate, angiogenesis, and corneal nerve loss...
October 11, 2018: Ocular Surface
Jerry R Paugh, Alba Alfonso-Garcia, Andrew Loc Nguyen, Jeffrey L Suhalim, Marjan Farid, Sumit Garg, Jeremiah Tao, Donald J Brown, Eric O Potma, James V Jester
PURPOSE: This study examined whether hyperspectral stimulated Raman scattering (hsSRS) microscopy can detect differences in meibum lipid to protein composition of normal and evaporative dry eye subjects with meibomian gland dysfunction. METHODS: Subjects were evaluated for tear breakup time (TBUT), staining, meibum expression and gland dropout. Expressed meibum was analyzed using SRS vibrational signatures in the CH stretching region (2800-3050 cm-1 ). Vertex component analysis and K-means clustering were used to group the spectral signatures into four fractions containing high lipid (G1) to high protein (G4)...
October 11, 2018: Ocular Surface
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