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Ocular Surface

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https://www.readbyqxmd.com/read/28179131/rasch-analysis-of-three-dry-eye-questionnaires-and-correlates-with-objective-clinical-tests
#1
Colm McAlinden, Rongrong Gao, Qinmei Wang, Senmiao Zhu, Jing Yang, Ayong Yu, Anthony J Bron, Jinhai Huang
PURPOSE: To assess the psychometric properties of Chinese versions of the Ocular Comfort Index (OCI), Ocular Surface Disease Index (OSDI) and McMonnies questionnaires. Further, to assess the correlation between questionnaire scores and objective dry eye disease (DED) clinical tests. METHODS: Translated versions of the OCI, OSDI and McMonnies questionnaires were completed in a random order by 238 participants with DED. Objective clinical tests included visual acuity (VA), fluorescein tear film break-up time (TBUT), corneal fluorescein staining, Schirmer I testing and meibomian gland grading...
February 4, 2017: Ocular Surface
https://www.readbyqxmd.com/read/28167204/changes-in-corneal-sub-basal-nerve-morphology-and-sensitivity-during-orthokeratology-recovery-of-change
#2
Edward Lum, Blanka Golebiowski, Helen A Swarbrick
PURPOSE: To investigate the recovery of changes in corneal nerve morphology and sensitivity in orthokeratology (OK) following lens wear discontinuation, over a 3-month period. METHODS: Sixteen myopic subjects who wore OK lenses during sleep for 3 months discontinued lens wear for 3 months. Corneal nerve morphology and sensitivity were assessed 3 h after waking on the right eye only at the pre-lens wear baseline and after lens wear discontinuation. Corneal nerve fiber density (NFD) and global nerve fiber orientation (GNFO) were assessed by sampling a 1 mm(2) area of the sub-basal nerve plexus at the corneal apex and temporal mid-periphery using in vivo confocal microscopy...
February 3, 2017: Ocular Surface
https://www.readbyqxmd.com/read/28137653/tidbits
#3
EDITORIAL
J Daniel Nelson
No abstract text is available yet for this article.
January 27, 2017: Ocular Surface
https://www.readbyqxmd.com/read/28137652/chemistry-matters
#4
LETTER
Gary D Novack
No abstract text is available yet for this article.
January 27, 2017: Ocular Surface
https://www.readbyqxmd.com/read/28132878/emerging-strategies-for-the-diagnosis-and-treatment-of-meibomian-gland-dysfunction-proceedings-of-the-ocean-group-meeting
#5
Gerd Geerling, Christophe Baudouin, Pasquale Aragona, Maurizio Rolando, Kostas G Boboridis, José M Benítez-Del-Castillo, Yonca A Akova, Jesús Merayo-Lloves, Marc Labetoulle, Martin Steinhoff, Elisabeth M Messmer
Meibomian gland dysfunction (MGD) is a common and chronic disorder that has a significant adverse impact on patients' quality of life. It is a leading cause of evaporative dry eye disease (DED), as meibomian glands play an important role in providing lipids to the tear film, which helps to retard the evaporation of tears from the ocular surface. MGD is also often present in conjunction with primary aqueous-deficient DED. Obstructive MGD, the most commonly observed type of MGD, is the main ocus of this article...
January 26, 2017: Ocular Surface
https://www.readbyqxmd.com/read/28131677/a-randomized-clinical-trial-to-evaluate-the-usefulness-of-amniotic-membrane-transplantation-in-bacterial-keratitis-healing
#6
Seyed Ali Tabatabaei, Mohammad Soleimani, Mahmoud Jabbarvand Behrouz, Ali Torkashvand, Pasha Anvari, Mehdi Yaseri
PURPOSE: To determine whether early amniotic membrane transplantation improves the outcomes among patients with bacterial keratitis. PATIENTS AND METHODS: In this prospective randomized clinical trial 49 eyes from 49 patients with bacterial keratitis received routine antibiotic therapy followed by double-layer amniotic membrane transplantation during 2-5 days after start up of the medications and the second group of 50 eyes from 50 patients only received routine antibacterial therapy...
January 25, 2017: Ocular Surface
https://www.readbyqxmd.com/read/28115245/autologous-method-for-ex-vivo-expansion-of-human-limbal-epithelial-progenitor-cells-based-on-plasma-rich-in-growth-factors-technology
#7
REVIEW
A C Riestra, N Vazquez, M Chacon, S Berisa, R M Sanchez-Avila, G Orive, E Anitua, A Meana, J Merayo-Lloves
PURPOSE: Develop an autologous culture method for ex vivo expansion of human limbal epithelial progenitor cells (LEPCs) using Plasma Rich in Growth Factors (PRGF) as a growth supplement and as a scaffold for the culture of LEPCs. METHODS: LEPCs were cultivated in different media supplemented with 10% fetal bovine serum (FBS) or 10% PRGF. The outgrowths, total number of cells, colony forming efficiency (CFE), morphology and immunocytochemistry against p63- α and cytokeratins 3 and 12 (CK3-CK12) were analyzed...
January 20, 2017: Ocular Surface
https://www.readbyqxmd.com/read/28109805/8th-international-conference-on-the-tear-film-ocular-surface-basic-science-and-clinical-relevance-montpellier-france-september-7-10-2016-highlights-from-the-platform-sessions
#8
https://www.readbyqxmd.com/read/28093340/bacteriological-profile-of-ocular-surface-flora-in-meibomian-gland-dysfunction
#9
Shao Dan Zhang, Jing Na He, Tong Tong Niu, Chiu Yeung Chan, Chun Yang Ren, Shan Shan Liu, Yang Qu, Kam Lung Chong, Hai Lin Wang, Jun Tao, Chi Pui Pang
PURPOSE: To compare the bacteriological profile of meibomian gland secretion and conjunctival cul-de-sac in subjects with and without meibomian gland dysfunction (MGD). METHODS: This hospital-based study enrolled 201 eyes from 201 MGD patients and 84 eyes from 84 age- and gender-matched controls. Samples from the conjunctivae and meibomian gland secretion were obtained. Both aerobic and anaerobic cultures were performed. Differences in the culture-positivity and bacterial strains between two groups were compared...
January 13, 2017: Ocular Surface
https://www.readbyqxmd.com/read/28065724/epidemiology-of-dry-eye-disease-in-africa-the-sparse-information-gaps-and-opportunities
#10
REVIEW
A E Osae, U Gehlsen, J Horstmann, S Siebelmann, M E Stern, D B Kumah, P Steven
Dry eye disease (DED) is an increasingly significant clinical problem in developing countries and/or emerging economies. Existing studies on DED conducted in these areas have largely reported on associations between DED and infectious disease (trachoma) and malnutrition (hypovitaminosis A), but current trends of industrialization, urbanization, and modernization in these areas could result in a shift to other forms of DED. Herein, we review the epidemiology of DED in these geographic areas, highlighting potential causes and risk factors of DED while presenting information on diagnostic tools and algorithms and insight into some treatment modalities of DED that could prove useful to clinicians and investigators in these regions...
January 5, 2017: Ocular Surface
https://www.readbyqxmd.com/read/28042094/bulbar-conjunctival-microvascular-responses-in-dry-eye
#11
Wan Chen, Hatim Ismail M Batawi, Jimmy R Alava, Anat Galor, Jin Yuan, Constantine D Sarantopoulos, Allison L McClellan, William J Feuer, Roy C Levitt, Jianhua Wang
PURPOSE: Conjunctival microvascular responses may be a surrogate metric of efferent neural pathway function innervating the ocular surface as changes in blood flow occur within seconds after a stimulus. As somatosensory dysfunction may partially underlie dry eye (DE), in this study we evaluate whether bulbar conjunctival microvascular alterations correlate with various aspects of DE. METHODS: Fifty-six DE patients were prospectively recruited from a Veterans Affairs ophthalmology clinic over an 11-month period...
December 29, 2016: Ocular Surface
https://www.readbyqxmd.com/read/27919798/femtosecond-laser-assisted-conjunctival-autograft-preparation-for-pterygium-surgery
#12
REVIEW
Matthias Fuest, Yu-Chi Liu, Gary Hin-Fai Yam, Ericia Pei Wen Teo, Hla Myint Htoon, Minas T Coroneo, Jodhbir S Mehta
PURPOSE: Pterygium is a common ocular surface disorder. Conjunctival autografting (CAG) following pterygium resection is the gold standard treatment. CAGs without Tenon's tissue provide better results but are more technically difficult to achieve. In this study, we evaluated the feasibility and reproducibility of femtosecond laser (FSL)-assisted CAG preparation. METHODS: Fifteen porcine globes were fixed in a suction holder and CAGs of different diameters were created by 1) an experienced consultant and 2) a less experienced fellow using the Ziemer LDV Z8...
December 2, 2016: Ocular Surface
https://www.readbyqxmd.com/read/27913232/visual-acuity-and-quality-of-life-in-dry-eye-disease-proceedings-of-the-ocean-group-meeting
#13
José Benítez-Del-Castillo, Marc Labetoulle, Christophe Baudouin, Maurizio Rolando, Yonca A Akova, Pasquale Aragona, Gerd Geerling, Jesús Merayo-Lloves, Elisabeth M Messmer, Kostas Boboridis
Dry eye disease (DED) results in tear film instability and hyperosmolarity, inflammation of the ocular surface and, ultimately, visual disturbance that can significantly impact a patient's quality of life. The effects on visual acuity result in difficulties with driving, reading and computer use and negatively impact psychological health. These effects also extend to the workplace, with a loss of productivity and quality of work causing substantial economic losses. The effects of DED and the impact on vision experienced by patients may not be given sufficient importance by ophthalmologists...
November 29, 2016: Ocular Surface
https://www.readbyqxmd.com/read/27871774/bias-to-basis
#14
EDITORIAL
J Daniel Nelson
No abstract text is available yet for this article.
January 2017: Ocular Surface
https://www.readbyqxmd.com/read/27871773/generally-regarded-as-safe
#15
LETTER
Gary D Novack
No abstract text is available yet for this article.
January 2017: Ocular Surface
https://www.readbyqxmd.com/read/27840126/the-intriguing-role-of-neuropeptides-at-the-ocular-surface
#16
REVIEW
Francesco Sabatino, Antonio Di Zazzo, Luca De Simone, Stefano Bonini
In recent decades, the role of neuropeptides in physiology and pathology has been elucidated. Various neuropeptides are expressed at the ocular surface, where they facilitate the crosstalk between immune and nervous systems. They actively regulate trophic and immune functions and orchestrate neuroinflammation. The purpose of this manuscript is to review the expression of the neuropeptides SP, VIP, CGRP, and NPY at the ocular surface, focusing on their role in tropism and immunity, and to summarize their functions in ocular immune privilege, infection, dry eye, and allergic eye disease...
January 2017: Ocular Surface
https://www.readbyqxmd.com/read/27816571/corneal-nerve-and-epithelial-cell-alterations-in-corneal-allodynia-an-in%C3%A2-vivo-confocal-microscopy-case-series
#17
Pedram Hamrah, Yureeda Qazi, Bashar Shahatit, Mohammad H Dastjerdi, Deborah Pavan-Langston, Deborah S Jacobs, Perry Rosenthal
PURPOSE: To investigate morphological changes of the corneal epithelium and subbasal nerves in patients with corneal allodynia using in vivo confocal microscopy (IVCM). DESIGN: Case-control study of patients with corneal allodynia and healthy controls. METHODS: Ten eyes of six patients were diagnosed with corneal allodynia at a single center and compared to fifteen healthy eyes. IVCM of the central cornea was performed on all subjects and controls...
January 2017: Ocular Surface
https://www.readbyqxmd.com/read/27816570/examination-of-gland-dropout-detected-on-infrared-meibography-by-using-optical-coherence-tomography-meibography
#18
Young-Sik Yoo, Kyung-Sun Na, Yong-Soo Byun, Jun Geun Shin, Byeong Ha Lee, Geunyoung Yoon, Tae Joong Eom, Choun-Ki Joo
PURPOSE: To elucidate the anatomic details of gland dropout detected on two-dimensional infrared (IR) meibography in cases of dry eye associated with meibomian gland dysfunction (MGD) by using three-dimensional optical coherence tomography (OCT) meibography. METHODS: In this cross-sectional, observational case series, we enrolled gland dropout detected on IR meibography; the condition was then examined using a real-time swept-source OCT system. Accordingly, a series of 500 raster B-scan OCT images, with the gland dropout site (observed on IR imaging) at the center, were obtained and rendered as three-dimensional volume images...
January 2017: Ocular Surface
https://www.readbyqxmd.com/read/27789276/tear-fluid-protein-changes-in-dry-eye-syndrome-associated-with-rheumatoid-arthritis-a-proteomic-approach
#19
Saijyothi Venkata Aluru, Agarwal Shweta, Srinivasan Bhaskar, Krishnan Geetha, Rajappa M Sivakumar, Tatu Utpal, Prema Padmanabhan, Narayanasamy Angayarkanni
PURPOSE: Sjögren syndrome (SS) secondary to rheumatoid arthritis (RA) affects lacrimal and salivary glands, and therefore dry eye syndrome (DES) is more prevalent in patients with RA. This study used a proteomic approach to identify potential biomarkers in tear of DES secondary to RA (DES-RA). METHODS: Tear specimens were collected with Schirmer strips from patients with DES with RA, patients with other types of dry eye (namely, primary Sjögrens and non-Sjögrens [NSS]), and age-matched controls...
January 2017: Ocular Surface
https://www.readbyqxmd.com/read/27771327/in%C3%A2-vivo-confocal-microscopy-of-corneal-nerves-in-health-and-disease
#20
REVIEW
Andrea Cruzat, Yureeda Qazi, Pedram Hamrah
In vivo confocal microscopy (IVCM) is becoming an indispensable tool for studying corneal physiology and disease. Enabling the dissection of corneal architecture at a cellular level, this technique offers fast and noninvasive in vivo imaging of the cornea with images comparable to those of ex vivo histochemical techniques. Corneal nerves bear substantial relevance to clinicians and scientists alike, given their pivotal roles in regulation of corneal sensation, maintenance of epithelial integrity, as well as proliferation and promotion of wound healing...
January 2017: Ocular Surface
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