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Ocular Surface

Ngozi Charity Chidi-Egboka, Nancy E Briggs, Isabelle Jalbert, Blanka Golebiowski
PURPOSE: A review of ocular surface and meta-analysis of tear stability (tear break up time, TBUT) and tear secretion (Schirmer test) values in healthy children was conducted. METHODS: Articles published between 1996 and 2017 indexed on MEDLINE, PubMed, Embase, Scopus and Google scholar were retrieved using defined search terms. Statistical analysis (including sensitivity analysis and meta regression) was performed. RESULTS: 23 studies were summarised (5291 neonates (0-29 days), infants (1 month-1 year) or children (1-18 years)) and a meta-analysis conducted using 15 eligible studies (1077 participants)...
September 30, 2018: Ocular Surface
Jennifer P Craig, Joevy Lim, Alicia Han, Leslie Tien, Ally L Xue, Michael T M Wang
PURPOSE: To investigate the ethnic differences in tear film quality, ocular surface parameters, and dry eye symptomology between co-located Asian and Caucasian populations. METHODS: Two hundred and six participants (103 Asian and 103 Caucasian) were recruited in an age and gender-matched cross-sectional study. Dry eye symptomology, ocular surface parameters, and tear film quality were evaluated for each participant within a single clinical session. RESULTS: The mean ± SD age of the 206 participants (82 male, 124 female) was 45 ± 16 years...
September 22, 2018: Ocular Surface
Veena C Karanam, Leonardo Tamariz, Hatim Batawi, Jianhua Wang, Anat Galor
PURPOSE: Our aim was to correlate cardiovascular risk factor estimation with bulbar conjunctival blood flow metrics as measured through Functional Slit Lamp Biomicroscopy (FSLB). METHODS: Cross-sectional study of individuals with otherwise healthy eyelid and corneal anatomy recruited from the Miami Veterans Affairs (VA) Healthcare System eye clinic. We measured conjunctival microvascular hemodynamics by mounting a camera on a slit lamp and cardiovascular risk using the Framingham risk score...
September 22, 2018: Ocular Surface
Venkata S Avadhanam, Jonathan Smith, Ali Poostchi, Jordan Chervenkoff, Nancy Al Raqqad, Ian Francis, Christopher S Liu
PURPOSE: To compare the clinical examination and computerized tomography (CT) scanning methods for the detection of laminar resorption in eyes with osteo-odonto-keratoprosthesis (OOKP). METHODS: Patients who developed laminar resorption after OOKP surgery and had at least one CT scan of the lamina during the follow-up were included. Case records and CT images and reports were retrospectively reviewed. Each lamina of the eye was regarded as a case. The imaging and clinical data were collected in Microsoft Excel, and statistical analysis was performed on Stata-v14...
September 15, 2018: Ocular Surface
Ji Soo Kim, Michael T M Wang, Jennifer P Craig
PURPOSE: To investigate the differences in ocular surface characteristics, tear film parameters, and dry eye symptomology between co-located pediatric populations of Asian and Caucasian ethnicity. METHODS: Seventy New Zealand-born pediatric participants, aged between 5 and 18 years, were recruited in an age and environmentally controlled cross-sectional study. Participants were classified into three groups according to ethnicity and eyelid morphology: Asian single lid (ASL), Asian double lid (ADL), and Caucasian double lid (CDL)...
September 13, 2018: Ocular Surface
Carolina L Mercado, Cameron Pole, James Wong, Juan F Batlle, Fabiola Roque, Noah Shaikh, Juan C Murillo, Anat Galor, Carol L Karp
PURPOSE: To characterize vision-related and psychosocial quality of life (QoL) parameters in medically and surgically treated patients with OSSN. METHODS: Forty-one patients with OSSN treated with medical therapy consisting of interferon alpha 2b drops 1 MIU/ml (n = 22) or who underwent surgical excision (n = 19) were contacted. All subjects answered a quality of life assessment with an original questionnaire in which they were asked about a range of parameters...
September 11, 2018: Ocular Surface
Venkata S Avadhanam, Mehran Zarei-Ghanavati, Ahmed Shalaby Bardan, Geetha Iyer, Bhaskar Srinivasan, Shweta Agarwal, Mohamed Goweida, Fukuda Masahiko, Konrad Hille, James Chodosh, Christopher S Liu
No abstract text is available yet for this article.
August 28, 2018: Ocular Surface
Ali Djalilian
No abstract text is available yet for this article.
August 27, 2018: Ocular Surface
Geetha Iyer, Bhaskar Srinivasan, Shweta Agarwal, Ramya Ravindran, Ekta Rishi, Pukhraj Rishi, Sripriya Krishnamoorthy
To analyse the anatomical and functionaloutcomes of Boston type II keratoprosthesis at a tertiary eye care centre in South India. Retrospective chart review of 10 patients operated with Boston keratoprosthesis Type 2 between Feb 2013 and June 2017 were analysed. Outcome measures analysed included, visual outcome, device retention and postoperative complications. The most common indication for surgery was SJS in 80% (8 of 10 eyes). Mean follow-up duration was 2.75 years (0.5-5 years, SD - 1.71, median 32 months) Postoperative visual acuity improved to better than 20/200 in 7 eyes and better than 20/30 in 6 eyes with device retention in 9 eyes at last follow-up...
August 26, 2018: Ocular Surface
Cintia S De Paiva
No abstract text is available yet for this article.
August 18, 2018: Ocular Surface
Yoshiaki Tagawa, Kousuke Noda, Takeshi Ohguchi, Yoshitsugu Tagawa, Susumu Ishida, Nobuyoshi Kitaichi
PURPOSE: To evaluate corneal tactile and pain sensations in patients with short tear film break-up time dry eye (sBUT DE). METHODS: This study enrolled 60 patients with sBUT DE and 46 healthy volunteers from Japan. We evaluated corneal tactile and pain sensations using a modified method with the Cochet-Bonnet corneal esthesiometer. RESULTS: Patients with sBUT DE had higher corneal pain sensitivity (26.3 ± 23.1 mm) than healthy subjects (6...
August 17, 2018: Ocular Surface
Gary D Novac
No abstract text is available yet for this article.
August 7, 2018: Ocular Surface
Xuhua Tan, Yihe Chen, William Foulsham, Afsaneh Amouzegar, Takenori Inomata, Yizhi Liu, Sunil K Chauhan, Reza Dana
PURPOSE: In this study, we examine the expression of corneal epithelium-derived thrombospondin-1 (TSP-1) and its immunomodulatory functions in a validated murine model of dry eye disease (DED). METHODS: DED was induced in female C57BL/6 using a controlled environment chamber (CEC) for 14 days. mRNA and protein expression of TSP-1 by corneal epithelial cells was quantified using real-time PCR and flow cytometry. Corneal epithelial cells from either naïve or DED mice were cultured with bone marrow derived dendritic cells (BMDCs) in the presence of IFNγ for 48 h, and BMDC expression of MHC-II and CD86 was determined using flow cytometry...
July 25, 2018: Ocular Surface
Mohsen Bahmani Kashkouli, Sayyed Amirpooya Alemzadeh, Hossein Aghaei, Farzad Pakdel, Parya Abdolalizadeh, Mahya Ghazizadeh, Farideh Moradpasandi
PURPOSE: To compare the subjective versus Objective dry eye disease (DED) in patients with moderate-severe thyroid eye disease (TED). METHOD: Included were the patients with moderate-severe TED and ≥18 years old. They completed the ocular surface disease index (OSDI) questionnaire and had Schirmer, Tear breakup time (TBUT), fluorescein staining, osmolarity, corneal aesthesiometry, and meibomian gland dysfunction (MGD) tests. Excluded were patients with history of any disease, surgery and or medications which might be affecting the ocular surface and incomplete tests results...
October 2018: Ocular Surface
Ho Sik Hwang, Yilu Xie, Elena Koudouna, Kyung-Sun Na, Young-Sik Yoo, Suk-Woo Yang, Donald J Brown, James V Jester
PURPOSE: While meibography has proven useful in identifying structural changes in the meibomian gland (MG), little is known regarding the MG spectral transmission and absorption characteristics. The purpose of this study was to measure the transmission/absorption spectra of the MG compared to other eyelid tissues. METHODS: Human and rabbit eyelids were fixed in paraformaldehyde, serial sectioned (50 μm) using a cryotome and imaged by brightfield and reflectance microscopy...
October 2018: Ocular Surface
Valerie Yu, Dhruva Bhattacharya, Andrew Webster, Aditi Bauskar, Charles Flowers, Martin Heur, Shravan K Chintala, Tatsuo Itakura, Mark R Wilson, Joseph T Barr, Shinwu Jeong, Mingwu Wang, M Elizabeth Fini
PURPOSE: To investigate the relationship between tear concentration of the homeostatic protein clusterin (CLU) and dry eye signs and symptoms, and to characterize tear CLU protein. METHODS: Two independent studies were conducted, one in Tucson (44 subjects), the other in Los Angeles (52 subjects). A cohort study design was employed to enroll patients without regard to dry eye diagnosis. Dry eye signs and symptoms were assessed using clinical tests. Tear samples were collected by Schirmer strip, and also by micropipette at slit lamp when possible...
October 2018: Ocular Surface
Sun Woong Kim, Yilu Xie, Paul Q Nguyen, Vickie T Bui, Kelly Huynh, Jonathan S Kang, Donald J Brown, James V Jester
PURPOSE: To evaluate the role of PPARγ in regulating meibocyte differentiation and lipid synthesis in a human meibomian gland epithelial cell line (hMGEC). METHODS: HMGEC were exposed to the PPARγ agonist, Rosiglitazone, from 10-50 μM. Cultures were also exposed to specific PPARγ antagonist, T0070907, to block PPARγ receptor signaling. Cells were then stained with Ki-67 and LipidTox to determine the effects on cell cycling and lipid synthesis, respectively...
July 7, 2018: Ocular Surface
Bhupesh Bagga, Swapna Reddy Motukupally, Ashik Mohamed
PURPOSE: To study the clinical and microbiological profile of microbial keratitis in Stevens-Johnson syndrome (SJS). STUDY DESIGN: Case series. PARTICIPANTS: Patients with SJS who developed microbial keratitis. METHODS: Medical records and microbiological data of patients with SJS who developed microbial keratitis from January 1991 to December 2012 were reviewed. We analysed the type of causative organisms and their antibiotic susceptibility along with the clinical pattern and responses to medications in this group of patients...
July 4, 2018: Ocular Surface
Ali Djalilian
No abstract text is available yet for this article.
July 2018: Ocular Surface
Gary D Novack
No abstract text is available yet for this article.
July 2018: Ocular Surface
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