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Ocular Surface

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https://www.readbyqxmd.com/read/28093340/bacteriological-profile-of-ocular-surface-flora-in-meibomian-gland-dysfunction
#1
Shao Dan Zhang, Jing Na He, Tong Tong Niu, Chiu Yeung Chan, Chun Yang Ren, Shan Shan Liu, Yang Qu, Kam Lung Chong, Hai Lin Wang, Jun Tao, Chi Pui Pang
PURPOSE: To compare the bacteriological profile of meibomian gland secretion and conjunctival cul-de-sac in subjects with and without meibomian gland dysfunction (MGD). METHODS: This hospital-based study enrolled 201 eyes from 201 MGD patients and 84 eyes from 84 age- and gender-matched controls. Samples from the conjunctivae and meibomian gland secretion were obtained. Both aerobic and anaerobic cultures were performed. Differences in the culture-positivity and bacterial strains between two groups were compared...
January 13, 2017: Ocular Surface
https://www.readbyqxmd.com/read/28065724/epidemiology-of-dry-eye-disease-in-africa-the-sparse-information-gaps-and-opportunities
#2
REVIEW
A E Osae, U Gehlsen, J Horstmann, S Siebelmann, M E Stern, D B Kumah, P Steven
Dry eye disease (DED) is an increasingly significant clinical problem in developing countries and/or emerging economies. Existing studies on DED conducted in these areas have largely reported on associations between DED and infectious disease (trachoma) and malnutrition (hypovitaminosis A), but current trends of industrialization, urbanization, and modernization in these areas could result in a shift to other forms of DED. Herein, we review the epidemiology of DED in these geographic areas, highlighting potential causes and risk factors of DED while presenting information on diagnostic tools and algorithms and insight into some treatment modalities of DED that could prove useful to clinicians and investigators in these regions...
January 5, 2017: Ocular Surface
https://www.readbyqxmd.com/read/28042094/bulbar-conjunctival-microvascular-responses-in-dry-eye
#3
Wan Chen, Hatim Ismail M Batawi, Jimmy R Alava, Anat Galor, Jin Yuan, Constantine D Sarantopoulos, Allison L McClellan, William J Feuer, Roy C Levitt, Jianhua Wang
PURPOSE: Conjunctival microvascular responses may be a surrogate metric of efferent neural pathway function innervating the ocular surface as changes in blood flow occur within seconds after a stimulus. As somatosensory dysfunction may partially underlie dry eye (DE), in this study we evaluate whether bulbar conjunctival microvascular alterations correlate with various aspects of DE. METHODS: Fifty-six DE patients were prospectively recruited from a Veterans Affairs ophthalmology clinic over an 11-month period...
December 29, 2016: Ocular Surface
https://www.readbyqxmd.com/read/27919798/femtosecond-laser-assisted-conjunctival-autograft-preparation-for-pterygium-surgery
#4
REVIEW
Matthias Fuest, Yu-Chi Liu, Gary Hin-Fai Yam, Ericia Pei Wen Teo, Hla Myint Htoon, Minas T Coroneo, Jodhbir S Mehta
PURPOSE: Pterygium is a common ocular surface disorder. Conjunctival autografting (CAG) following pterygium resection is the gold standard treatment. CAGs without Tenon's tissue provide better results but are more technically difficult to achieve. In this study, we evaluated the feasibility and reproducibility of femtosecond laser (FSL)-assisted CAG preparation. METHODS: Fifteen porcine globes were fixed in a suction holder and CAGs of different diameters were created by 1) an experienced consultant and 2) a less experienced fellow using the Ziemer LDV Z8...
December 2, 2016: Ocular Surface
https://www.readbyqxmd.com/read/27913232/visual-acuity-and-quality-of-life-in-dry-eye-disease-proceedings-of-the-ocean-group-meeting
#5
José Benítez-Del-Castillo, Marc Labetoulle, Christophe Baudouin, Maurizio Rolando, Yonca A Akova, Pasquale Aragona, Gerd Geerling, Jesús Merayo-Lloves, Elisabeth M Messmer, Kostas Boboridis
Dry eye disease (DED) results in tear film instability and hyperosmolarity, inflammation of the ocular surface and, ultimately, visual disturbance that can significantly impact a patient's quality of life. The effects on visual acuity result in difficulties with driving, reading and computer use and negatively impact psychological health. These effects also extend to the workplace, with a loss of productivity and quality of work causing substantial economic losses. The effects of DED and the impact on vision experienced by patients may not be given sufficient importance by ophthalmologists...
November 29, 2016: Ocular Surface
https://www.readbyqxmd.com/read/27871774/bias-to-basis
#6
EDITORIAL
J Daniel Nelson
No abstract text is available yet for this article.
January 2017: Ocular Surface
https://www.readbyqxmd.com/read/27871773/generally-regarded-as-safe
#7
LETTER
Gary D Novack
No abstract text is available yet for this article.
January 2017: Ocular Surface
https://www.readbyqxmd.com/read/27840126/the-intriguing-role-of-neuropeptides-at-the-ocular-surface
#8
REVIEW
Francesco Sabatino, Antonio Di Zazzo, Luca De Simone, Stefano Bonini
In recent decades, the role of neuropeptides in physiology and pathology has been elucidated. Various neuropeptides are expressed at the ocular surface, where they facilitate the crosstalk between immune and nervous systems. They actively regulate trophic and immune functions and orchestrate neuroinflammation. The purpose of this manuscript is to review the expression of the neuropeptides SP, VIP, CGRP, and NPY at the ocular surface, focusing on their role in tropism and immunity, and to summarize their functions in ocular immune privilege, infection, dry eye, and allergic eye disease...
January 2017: Ocular Surface
https://www.readbyqxmd.com/read/27816571/corneal-nerve-and-epithelial-cell-alterations-in-corneal-allodynia-an-in%C3%A2-vivo-confocal-microscopy-case-series
#9
Pedram Hamrah, Yureeda Qazi, Bashar Shahatit, Mohammad H Dastjerdi, Deborah Pavan-Langston, Deborah S Jacobs, Perry Rosenthal
PURPOSE: To investigate morphological changes of the corneal epithelium and subbasal nerves in patients with corneal allodynia using in vivo confocal microscopy (IVCM). DESIGN: Case-control study of patients with corneal allodynia and healthy controls. METHODS: Ten eyes of six patients were diagnosed with corneal allodynia at a single center and compared to fifteen healthy eyes. IVCM of the central cornea was performed on all subjects and controls...
January 2017: Ocular Surface
https://www.readbyqxmd.com/read/27816570/examination-of-gland-dropout-detected-on-infrared-meibography-by-using-optical-coherence-tomography-meibography
#10
Young-Sik Yoo, Kyung-Sun Na, Yong-Soo Byun, Jun Geun Shin, Byeong Ha Lee, Geunyoung Yoon, Tae Joong Eom, Choun-Ki Joo
PURPOSE: To elucidate the anatomic details of gland dropout detected on two-dimensional infrared (IR) meibography in cases of dry eye associated with meibomian gland dysfunction (MGD) by using three-dimensional optical coherence tomography (OCT) meibography. METHODS: In this cross-sectional, observational case series, we enrolled gland dropout detected on IR meibography; the condition was then examined using a real-time swept-source OCT system. Accordingly, a series of 500 raster B-scan OCT images, with the gland dropout site (observed on IR imaging) at the center, were obtained and rendered as three-dimensional volume images...
January 2017: Ocular Surface
https://www.readbyqxmd.com/read/27789276/tear-fluid-protein-changes-in-dry-eye-syndrome-associated-with-rheumatoid-arthritis-a-proteomic-approach
#11
Saijyothi Venkata Aluru, Agarwal Shweta, Srinivasan Bhaskar, Krishnan Geetha, Rajappa M Sivakumar, Tatu Utpal, Prema Padmanabhan, Narayanasamy Angayarkanni
PURPOSE: Sjögren syndrome (SS) secondary to rheumatoid arthritis (RA) affects lacrimal and salivary glands, and therefore dry eye syndrome (DES) is more prevalent in patients with RA. This study used a proteomic approach to identify potential biomarkers in tear of DES secondary to RA (DES-RA). METHODS: Tear specimens were collected with Schirmer strips from patients with DES with RA, patients with other types of dry eye (namely, primary Sjögrens and non-Sjögrens [NSS]), and age-matched controls...
January 2017: Ocular Surface
https://www.readbyqxmd.com/read/27771327/in%C3%A2-vivo-confocal-microscopy-of-corneal-nerves-in-health-and-disease
#12
REVIEW
Andrea Cruzat, Yureeda Qazi, Pedram Hamrah
In vivo confocal microscopy (IVCM) is becoming an indispensable tool for studying corneal physiology and disease. Enabling the dissection of corneal architecture at a cellular level, this technique offers fast and noninvasive in vivo imaging of the cornea with images comparable to those of ex vivo histochemical techniques. Corneal nerves bear substantial relevance to clinicians and scientists alike, given their pivotal roles in regulation of corneal sensation, maintenance of epithelial integrity, as well as proliferation and promotion of wound healing...
January 2017: Ocular Surface
https://www.readbyqxmd.com/read/27725302/new-perspectives-on-dry-eye-definition-and-diagnosis-a-consensus-report-by-the-asia-dry-eye-society
#13
REVIEW
Kazuo Tsubota, Norihiko Yokoi, Jun Shimazaki, Hitoshi Watanabe, Murat Dogru, Masakazu Yamada, Shigeru Kinoshita, Hyo-Myung Kim, Hung-Won Tchah, Joon Young Hyon, Kyung-Chul Yoon, Kyoung Yul Seo, Xuguang Sun, Wei Chen, Lingyi Liang, Mingwu Li, Zuguo Liu
For the last 20 years, a great amount of evidence has accumulated through epidemiological studies that most of the dry eye disease encountered in daily life, especially in video display terminal (VDT) workers, involves short tear film breakup time (TFBUT) type dry eye, a category characterized by severe symptoms but minimal clinical signs other than short TFBUT. An unstable tear film also affects the visual function, possibly due to the increase of higher order aberrations. Based on the change in the understanding of the types, symptoms, and signs of dry eye disease, the Asia Dry Eye Society agreed to the following definition of dry eye: "Dry eye is a multifactorial disease characterized by unstable tear film causing a variety of symptoms and/or visual impairment, potentially accompanied by ocular surface damage...
January 2017: Ocular Surface
https://www.readbyqxmd.com/read/27678525/defining-ocular-surface-disease-activity-and-damage-indices-by-an-international-delphi-consultation
#14
Priscilla A Mathewson, Geraint P Williams, Stephanie L Watson, James Hodson, Anthony J Bron, Saaeha Rauz
PURPOSE: Unifying terminology for the description of ocular surface disease (OSD) is vital for determining treatment responses and ensuring robust clinical trial outcomes. To date, there are no agreed parameters describing 'activity' and 'damage' phases of disease. METHODS: A working group of international experts in OSD, oculoplastics, and uveitis from a range of backgrounds (university, teaching, district general and private hospitals) participated in a modified Delphi consensus-building exercise (October 31, 2011 to March 20, 2015)...
January 2017: Ocular Surface
https://www.readbyqxmd.com/read/27670247/human-tear-fluid-reduces-culturability-of-contact%C3%A2-lens-associated-pseudomonas-aeruginosa-biofilms-but-induces-expression-of-the-virulence-associated-type-iii-secretion-system
#15
Yvonne T Wu, Connie Tam, Lucia S Zhu, David J Evans, Suzanne M J Fleiszig
PURPOSE: The type III secretion system (T3SS) is a significant virulence determinant for Pseudomonas aeruginosa. Using a rodent model, we found that contact lens (CL)-related corneal infections were associated with lens surface biofilms. Here, we studied the impact of human tear fluid on CL-associated biofilm growth and T3SS expression. METHODS: P. aeruginosa biofilms were formed on contact lenses for up to 7 days with or without human tear fluid, then exposed to tear fluid for 5 or 24 h...
January 2017: Ocular Surface
https://www.readbyqxmd.com/read/27650263/current-and-upcoming-therapies-for-ocular-surface-chemical-injuries
#16
REVIEW
Alireza Baradaran-Rafii, Medi Eslani, Zeeshan Haq, Ebrahim Shirzadeh, Michael J Huvard, Ali R Djalilian
Chemical injuries frequently result in vision loss, disfigurement, and challenging ocular surface complications. Acute interventions are directed at decreasing the extent of the injury, suppressing inflammation, and promoting ocular surface re-epithelialization. Chronically, management involves controlling inflammation along with rehabilitation and reconstruction of the ocular surface. Future therapies aimed at inhibiting neovascularization and promoting ocular surface regeneration should provide more effective treatment options for the management of ocular chemical injuries...
January 2017: Ocular Surface
https://www.readbyqxmd.com/read/27614318/a-two-week-randomized-double-masked-study-to-evaluate-safety-and-efficacy-of-lubricin-150%C3%A2-%C3%AE-g-ml-eye-drops-versus-sodium-hyaluronate-ha-0-18-eye-drops-vismed%C3%A2-in-patients-with-moderate-dry-eye-disease
#17
Alessandro Lambiase, Benjamin D Sullivan, Tannin A Schmidt, David A Sullivan, Gregory D Jay, Edward R Truitt, Alice Bruscolini, Marta Sacchetti, Flavio Mantelli
PURPOSE: The objective of this clinical trial (NCT02507934) was to assess the efficacy and safety of recombinant human lubricin as compared to a 0.18% sodium hyaluronate (HA) eye drop in subjects with moderate dry eye disease (DED). METHODS: DEWS Grade 2-3 subjects were randomized to use lubricin (N=19, 51.9 ± 11.8 years) or HA (N=20, 61.8 ± 13.3 years). After a saline washout period, subjects administered BID therapy for 7 days, followed by instillation as needed (2-6 drops per eye) for 7 days...
January 2017: Ocular Surface
https://www.readbyqxmd.com/read/27742001/natural-does-not-mean-safe
#18
Gary D Novack
No abstract text is available yet for this article.
October 2016: Ocular Surface
https://www.readbyqxmd.com/read/27567542/dogma
#19
J Daniel Nelson
No abstract text is available yet for this article.
October 2016: Ocular Surface
https://www.readbyqxmd.com/read/27555566/abnormal-anterior-corneal-morphology-in-diabetes-observed-using-in%C3%A2-vivo-laser-scanning-confocal-microscopy
#20
Cirous Dehghani, Nicola Pritchard, Katie Edwards, Anthony W Russell, Rayaz A Malik, Nathan Efron
PURPOSE: To assess if diabetes alters corneal epithelial, anterior stromal and subbasal nerve plexus morphology and to determine the associations between these and other clinical variables. METHODS: A cohort of 78 participants with diabetes (39 with Type 1 and 39 with Type 2 diabetes) and 29 age-matched healthy controls underwent laser-scanning confocal microscopy of the central cornea. Intermediate cell density (ICD), basal cell density (BCD), anterior stromal cell density (ASCD), corneal nerve fiber density (CNFD) and nerve fiber length (CNFL) were quantified...
October 2016: Ocular Surface
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