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Ocular Surface

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https://www.readbyqxmd.com/read/29452252/compared-to-what-the-placebo-effect-in-dry-eye-therapy
#1
LETTER
Gary D Novack
No abstract text is available yet for this article.
February 13, 2018: Ocular Surface
https://www.readbyqxmd.com/read/29425812/assessment-of-the-prosthetic-replacement-of-ocular-surface-ecosystem-prose-scleral-lens-on-visual-acuity-for-corneal-irregularity-and-ocular-surface-disease
#2
Andres Parra, Bryan M Roth, Taylor M Nguyen, Li Wang, Stephen C Pflugfelder, Zaina Al-Mohtaseb
PURPOSE: To describe changes in visual acuity in patients fit with the Prosthetic Replacement of Ocular Surface Ecosystem (PROSE) with irregular corneas compared to those with ocular surface disease, as well as describe patient demographics and fitting indications for PROSE at an academic medical center. METHODS: A retrospective chart review from 2010 to 2016 on a total of 825 eyes from 493 patients fitted with a PROSE lens, and grouped by etiology, either irregular cornea/dystrophy or ocular surface disease and associated sub-etiologies...
February 6, 2018: Ocular Surface
https://www.readbyqxmd.com/read/29409963/web-based-longitudinal-remote-assessment-of-dry-eye-symptoms
#3
Francisco Amparo, Reza Dana
PURPOSE: To investigate the feasibility of remote assessment and follow-up of dry eye symptoms using electronic versions of two validated questionnaires. METHODS: We conducted a prospective study of consecutive patients with dry eye disease (DED). Patients were enrolled during a clinical visit and were explained how to respond electronic versions of the Ocular surface Disease Index (OSDI) and the Symptom Assessment in Dry Eye (SANDE) questionnaires using a computer in the presence of investigators...
January 31, 2018: Ocular Surface
https://www.readbyqxmd.com/read/29317327/sex-differences-in-clinical-characteristics-of-dry-eye-disease
#4
Jelle Vehof, Nicole Sillevis Smitt-Kamminga, Simone A Nibourg, Christopher J Hammond
PURPOSE: To investigate the role of sex on the symptomatology of DED and on the associations between symptoms and signs. METHODS: A cross-sectional study was used including 755 dry eye patients from the Groningen Longitudinal Sicca Study (GLOSSY cohort). Patient symptoms were assessed by the Ocular Surface Disease Index (OSDI) questionnaire and dry eye signs by the six most commonly used tests. Patients were divided in groups based on overall severity of signs and within these groups total and specific symptoms were compared by sex...
January 6, 2018: Ocular Surface
https://www.readbyqxmd.com/read/29309844/development-of-an-in-vitro-model-to-study-the-biological-effects-of-blinking
#5
Guoting Qin, Hasna Baidouri, Adrian Glasser, VijayKrishna Raghunathan, Carol Morris, Inna Maltseva, Alison M McDermott
PURPOSE: To develop a mechanical model in which a contact lens is swept over ocular surface cells under conditions that mimic the force and speed of the blink, and to investigate the resulting biological changes. METHODS: A computer controlled mechanical instrument was developed to hold a dish containing 3D cultured stratified human ocular surface epithelial cells, across which an arm bearing a contact lens was swept back and forth repeatedly at a speed and force mimicking the human blink...
January 5, 2018: Ocular Surface
https://www.readbyqxmd.com/read/29306088/changes-in-in-vivo-confocal-microscopic-findings-of-ocular-surface-squamous-neoplasia-during-treatment-with-topical-interferon-alfa-2b
#6
Mehran Zarei-Ghanavati, Ebrahim Mousavi, Amin Nabavi, Golshan Latifi, Hadi Z Mehrjardi, Masoomeh Mohebbi, Hamed Ghassemi, Farrin Mirzaie, Mohammad Ali Zare
PURPOSE: To evaluate in vivo confocal microscopy (IVCM) findings of ocular surface squamous neoplasia (OSSN) during treatment with topical interferon alfa-2b (IFN alfa-2b). METHODS: In this prospective interventional case series, 20 eyes from 20 patients with OSSN were treated with topical IFN alfa-2b 3 million IU/mL four times a day. Treatment was continued for 2 or 3 months after clinical resolution. IVCM was done at baseline, on a monthly basis, and at the end of treatment...
January 3, 2018: Ocular Surface
https://www.readbyqxmd.com/read/29305292/corneal-nerve-regeneration-after-herpes-simplex-keratitis-an-in-vivo-confocal-microscopy-study
#7
Hamid-Reza Moein, Ahmad Kheirkhah, Rodrigo T Muller, Andrea C Cruzat, Deborah Pavan-Langston, Pedram Hamrah
PURPOSE: To evaluate the long-term alterations in corneal nerves in patients with herpes simplex virus (HSV) keratitis using in vivo confocal microscopy (IVCM). DESIGN: Prospective longitudinal, cross sectional. METHODS: This study included 16 patients with history of HSV keratitis and 15 age-matched normal controls. Slit-scanning IVCM was performed in all subjects at baseline and then after a mean follow-up of 37.3 ± 1.7 months in the patient group...
January 2, 2018: Ocular Surface
https://www.readbyqxmd.com/read/29306389/moving-forward-filling-giant-shoes
#8
EDITORIAL
Ali Djalilian
No abstract text is available yet for this article.
January 2018: Ocular Surface
https://www.readbyqxmd.com/read/29113918/the-impact-of-diabetes-on-corneal-nerve-morphology-and-ocular-surface-integrity
#9
REVIEW
Maria Markoulli, Judith Flanagan, Shyam Sunder Tummanapalli, Jenny Wu, Mark Willcox
Diabetes mellitus is a chronic disease that results from inadequate insulin production or ineffective insulin utilization. It is one of the most common systemic diseases worldwide with increasing prevalence. Diabetes mellitus is associated with premature mortality, macrovascular complications such as cardiovascular disease, and microvascular complications, including nephropathy leading to kidney failure, potentially blinding diabetic retinopathy, and diabetic neuropathy. While the retinal complications of diabetes are well recognized by eye care professionals, the effects on the ocular surface are poorly understood...
January 2018: Ocular Surface
https://www.readbyqxmd.com/read/29113917/the-diagnosis-of-limbal-stem-cell-deficiency
#10
REVIEW
Qihua Le, Jianjiang Xu, Sophie X Deng
Limbal stem cells (LSCs) maintain the normal homeostasis and wound healing of corneal epithelium. Limbal stem cell deficiency (LSCD) is a pathologic condition that results from the dysfunction and/or an insufficient quantity of LSCs. The diagnosis of LSCD has been made mainly based on medical history and clinical signs, which often are not specific to LSCD. Methods to stage the severity of LSCD have been lacking. With the application of newly developed ocular imaging modalities and molecular methods as diagnostic tools, standardized quantitative criteria for the staging of LSCD can be established...
January 2018: Ocular Surface
https://www.readbyqxmd.com/read/29107624/a-simple-and-cost-effective-method-for-preparing-fl-and-lg-solutions
#11
Deborah Awisi Gyau, Carolyn G Begley, J Daniel Nelson
PURPOSE: The purpose of this study was to develop a clinically feasible method for obtaining dye concentrations of 2% fluorescein (FL) and 1% lissamine green (LG) by soaking commercially available dye impregnated strips in saline. METHODS: Calibration curves were established to related known concentrations of dye to prepared FL fluorescence and LG absorbance. To determine the optimum number of dye strips and soaking times (preliminary testing), 1, 2, 3 FL or LG strips were soaked in 200 μl commercially available saline for 0...
January 2018: Ocular Surface
https://www.readbyqxmd.com/read/28919238/post-blink-tear-film-dynamics-in-healthy-and-dry-eyes-during-spontaneous-blinking
#12
Dorota H Szczesna-Iskander
PURPOSE: The aim was to investigate the dynamics of post-blink tear film leveling in natural blinking conditions (NBC) for healthy subjects and those diagnosed with dry eye syndrome (DES) and to relate this phase to the tear film surface quality (TFSQ) before the following blink. METHODS: The study included 19 healthy persons and 10 with dry eye, grouped according to symptoms and signs observed during examination. Lateral shearing interferometry was used to examine TFSQ...
January 2018: Ocular Surface
https://www.readbyqxmd.com/read/29154841/grateful-and-thankful
#13
EDITORIAL
J Daniel Nelson
No abstract text is available yet for this article.
November 14, 2017: Ocular Surface
https://www.readbyqxmd.com/read/29154840/thoughts-on-improving-medication-use
#14
LETTER
Gary D Novack
No abstract text is available yet for this article.
November 14, 2017: Ocular Surface
https://www.readbyqxmd.com/read/29133179/stage-related-central-corneal-epithelial-transformation-in-congenital-aniridia-associated-keratopathy
#15
Neil Lagali, Bogumil Wowra, Dariusz Dobrowolski, Tor Paaske Utheim, Per Fagerholm, Edward Wylegala
PURPOSE: To relate central corneal epithelial phenotype to degree of keratopathy in a limbal stem cell deficient population. METHODS: 37 patients (67 eyes) with aniridia-associated keratopathy (AAK) underwent corneal examination including slit lamp biomicroscopy to determine the Grade of AAK, Cochet-Bonnet esthesiometry, and in vivo confocal microscopy (IVCM) to assess morphology of the central corneal epithelium and subepithelial region. RESULTS: AAK Grade ranged from 1 (limbal involvement only) to 4 (total conjunctivalisation), with progression from Grade 1 occurring after the age of 20...
November 10, 2017: Ocular Surface
https://www.readbyqxmd.com/read/29129753/nitrogen-mustard-induced-corneal-injury-involves-the-sphingomyelin-ceramide-pathway
#16
Georgia Charkoftaki, James Jester, David Thompson, Vasilis Vasiliou
PURPOSE: Nitrogen mustard (NM), which simulates the effects of sulfur mustard (SM), is a potent vesicant known to cause irreversible corneal damage. This study investigates the mechanisms by which NM induces corneal damage by examining the impact of NM exposure on the morphology and lipidome of the cornea. METHODS: Intact ex vivo rabbit eyes were placed in serum-free DMEM organ culture. NM (0, 1, 2.5, 5 or 10 mg/ml) was applied to the central cornea for 5, 10 or 15 min using a 5 mm filter disk and subsequently rinsed with DMEM...
November 9, 2017: Ocular Surface
https://www.readbyqxmd.com/read/29128682/randomized-double-masked-trial-of-eyelid-cleansing-treatments-for-blepharitis
#17
Justin Sung, Michael T M Wang, Sang H Lee, Isabella M Y Cheung, Salim Ismail, Trevor Sherwin, Jennifer P Craig
PURPOSE: To compare the efficacy of a dedicated eyelid cleanser and diluted baby shampoo in the management of blepharitis. METHODS: Forty-three participants with clinical blepharitis signs were enrolled in a prospective, randomized, double-masked, paired-eye trial. A dedicated eyelid cleanser (TheraTears® SteriLid®) was applied to the eyelids of one eye (randomized) and diluted baby shampoo (Johnson's® No More Tears®) to the fellow eye, twice daily for 4 weeks...
November 8, 2017: Ocular Surface
https://www.readbyqxmd.com/read/29104070/the-role-of-amniotic-membrane-extract-eye-drop-ameed-in-in-vivo-cultivation-of-limbal-stem-cells
#18
Alireza Baradaran-Rafii, Niloufar Shayan Asl, Marzieh Ebrahimi, Sayena Jabbehdari, Shahram Bamdad, Danial Roshandel, Medi Eslani, Maryam Momeni
BACKGROUND: Limbal stem cell transplantation (LSCT) is the definitive treatment for total limbal stem cell deficiency (LSCD). This study evaluates the anatomical and visual outcomes of a surgical technique supplemented by amniotic membrane extract eye drop (AMEED) for in vivo cultivation of limbal stem cells (LSCs). METHODS: One small limbal block (2 × 1 mm) harvested from the contralateral healthy eye was transferred to the diseased eye, which had been already covered by cryopreserved amniotic membrane (N = 20)...
November 2, 2017: Ocular Surface
https://www.readbyqxmd.com/read/29032001/efficacy-of-self-retained-cryopreserved-amniotic-membrane-for-treatment-of-neuropathic-corneal-pain
#19
Melina I Morkin, Pedram Hamrah
PURPOSE: Treatment of neuropathic corneal pain (NCP) remains intricate, and involves a long-term combined multistep approach. The self-retained cryopreserved amniotic membrane (PROKERA(®), Bio-Tissue, Miami,FL) has been utilized for multiple ocular surface disorders. We evaluate the efficacy, safety, and tolerability of ProKera(®) Slim [PKS] and ProKera(®) Clear [PKC] in the treatment of NCP. METHODS: Retrospective case series of 9 patients who received PKS/PKC for the acute treatment of NCP...
October 12, 2017: Ocular Surface
https://www.readbyqxmd.com/read/29031646/international-publication-trends-in-dry-eye-disease-research-a-bibliometric-analysis
#20
Christophe Boudry, C Baudouin, Fréderic Mouriaux
PURPOSE: To perform a bibliometric analysis in the field of dry eye disease (DED) research to characterize the current international status of DED research and to identify the most effective actors (journals, countries, authors) involved in this field. METHODS: Scientometric methods were used to evaluate global scientific production and development trends in DED research using the Web of Science Core Collection. RESULTS: The growth of the literature related to DED averaged 12...
October 11, 2017: Ocular Surface
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