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Ocular Surface

Gary D Novac
No abstract text is available yet for this article.
August 7, 2018: Ocular Surface
Valerie Yu, Dhruva Bhattacharya, Andrew Webster, Aditi Bauskar, Charles Flowers, Martin Heur, Shravan K Chintala, Tatsuo Itakura, Mark R Wilson, Joseph T Barr, Shinwu Jeong, Mingwu Wang, M Elizabeth Fini
PURPOSE: To investigate the relationship between tear concentration of the homeostatic protein clusterin (CLU) and dry eye signs and symptoms, and to characterize tear CLU protein. METHODS: Two independent studies were conducted, one in Tucson (44 subjects), the other in Los Angeles (52 subjects). A cohort study design was employed, enrolling patients without regard to dry eye diagnosis. Dry eye signs and symptoms were assessed using clinical tests. Tear samples were collected by Schirmer strip, and also by micropipette at slit lamp when possible...
August 2, 2018: Ocular Surface
Xuhua Tan, Yihe Chen, William Foulsham, Afsaneh Amouzegar, Takenori Inomata, Yizhi Liu, Sunil K Chauhan, Reza Dana
PURPOSE: In this study, we examine the expression of corneal epithelium-derived thrombospondin-1 (TSP-1) and its immunomodulatory functions in a validated murine model of dry eye disease (DED). METHODS: DED was induced in female C57BL/6 using a controlled environment chamber (CEC) for 14 days. mRNA and protein expression of TSP-1 by corneal epithelial cells was quantified using real-time PCR and flow cytometry. Corneal epithelial cells from either naïve or DED mice were cultured with bone marrow derived dendritic cells (BMDCs) in the presence of IFNγ for 48 h, and BMDC expression of MHC-II and CD86 was determined using flow cytometry...
July 25, 2018: Ocular Surface
Sun Woong Kim, Yilu Xie, Paul Q Nguyen, Vickie T Bui, Kelly Huynh, Jonathan S Kang, Donald J Brown, James V Jester
PURPOSE: To evaluate the role of PPARγ in regulating meibocyte differentiation and lipid synthesis in a human meibomian gland epithelial cell line (hMGEC). METHODS: HMGEC were exposed to the PPARγ agonist, Rosiglitazone, from 10-50 μM. Cultures were also exposed to specific PPARγ antagonist, T0070907, to block PPARγ receptor signaling. Cells were then stained with Ki-67 and LipidTox to determine the effects on cell cycling and lipid synthesis, respectively...
July 7, 2018: Ocular Surface
Bhupesh Bagga, Swapna Reddy Motukupally, Ashik Mohamed
PURPOSE: To study the clinical and microbiological profile of microbial keratitis in Stevens-Johnson syndrome (SJS). STUDY DESIGN: Case series. PARTICIPANTS: Patients with SJS who developed microbial keratitis. METHODS: Medical records and microbiological data of patients with SJS who developed microbial keratitis from January 1991 to December 2012 were reviewed. We analysed the type of causative organisms and their antibiotic susceptibility along with the clinical pattern and responses to medications in this group of patients...
July 4, 2018: Ocular Surface
Tong L, Hou Ah, Wong Tt
PURPOSE: We aim to evaluate changes in the ocular surface in a cohort of post-trabeculectomy patients and whether these were associated with conjunctival inflammatory gene expression. METHODS: This is a single-arm interventional cohort performed in a tertiary referral center. These were assessed: dry eye symptom questionnaire, tear osmolarity, Schirmer's test, non-invasive tear break up time (BUT), conjunctival redness and corneal fluorescein staining evaluation...
June 21, 2018: Ocular Surface
Danial Roshandel, Medi Eslani, Alireza Baradaran-Rafii, Albert Y Cheung, Khaliq Kurji, Sayena Jabbehdari, Alejandra Maiz, Setareh Jalali, Ali R Djalilian, Edward J Holland
The cornea is unique because of its complete avascularity. Corneal neovascularization (CNV) can result from a variety of etiologies including contact lens wear; corneal infections; and ocular surface diseases due to inflammation, chemical injury, and limbal stem cell deficiency. Management is focused primarily on the etiology and pathophysiology causing the CNV and involves medical and surgical options. Because inflammation is a key factor in the pathophysiology of CNV, corticosteroids and other anti-inflammatory medications remain the mainstay of treatment...
June 14, 2018: Ocular Surface
Michael T M Wang, Leslie Tien, Alicia Han, Jung Min Lee, Dabin Kim, Maria Markoulli, Jennifer P Craig
PURPOSE: To investigate the influence of blinking on tear film parameters, ocular surface characteristics, and dry eye symptomology. METHODS: A total of 154 participants were recruited in an age, gender and ethnicity-matched cross-sectional study, of which 77 exhibited clinically detectable incomplete blinking, and 77 did not. Blink rate, dry eye symptomology, tear film parameters, and ocular surface characteristics were assessed in a single clinical session. RESULTS: Overall, a higher proportion of participants exhibiting incomplete blinking fulfilled the TFOS DEWS II dry eye diagnostic criteria (64% versus 44%, p = 0...
June 5, 2018: Ocular Surface
Ilaria Macchi, Vatinee Y Bunya, Mina Massaro-Giordano, Richard A Stone, Maureen G Maguire, Yuanjie Zheng, Min Chen, James Gee, Eli Smith, Ebenezer Daniel
PURPOSE: Current scales for assessment of bulbar conjunctival redness have limitations for evaluating digital images. We developed a scale suited for evaluating digital images and compared it to the Validated Bulbar Redness (VBR) scale. METHODS: From a digital image database of 4889 color corrected bulbar conjunctival images, we identified 20 images with varied degrees of redness. These images, ten each of nasal and temporal views, constitute the Digital Bulbar Redness (DBR) scale...
June 5, 2018: Ocular Surface
Miki Uchino, Motoko Kawashima, Yuichi Uchino, Natume Suzuki, Hiroto Mitamura, Miki Mizuno, Yuichi Hori, Norihiko Yokoi, Kazuo Tsubota
PURPOSE: To evaluate the usefulness of a dry eye mobile application (app) for screening dry eye disease (DED) at educational tear events in Japan. METHODS: In this cross-sectional study, Japanese subjects visiting a "Tears Day" event were selected randomly. They completed questionnaires and underwent ophthalmic evaluations for DED (using Japanese revised diagnostic criteria) including a functional visual acuity (FVA) test. The app calculated FVA using the average of the continuous VA over 30 s...
June 5, 2018: Ocular Surface
Ali Djalilian
No abstract text is available yet for this article.
July 2018: Ocular Surface
Gary D Novack
No abstract text is available yet for this article.
July 2018: Ocular Surface
José Pinto-Fraga, Amalia Enríquez-de-Salamanca, Margarita Calonge, María J González-García, Alberto López-Miguel, Alberto López-de la Rosa, Carmen García-Vázquez, Virginia Calder, Michael E Stern, Itziar Fernández
PURPOSE: To evaluate the effect of 0.1%-fluorometholone (FML) on tear inflammatory molecule levels after 22-days treatment in dry eye disease (DED) patients exposed to an adverse controlled environment (ACE), identifying different biomarkers. METHODS: Analysis of a double-masked randomized clinical trial. Forty-one DED patients received 4-drops daily of topical FML (FML-group) or polyvinyl-alcohol (PA-group) for 22 days. At day 21, patients were exposed to an ACE...
July 2018: Ocular Surface
Francisco Amparo, Hasanain Shikari, Ujwala Saboo, Reza Dana
PURPOSE: To evaluate long-term ocular surface clinical signs and symptoms response to therapy in patients with chronic ocular GVHD. METHODS: Retrospective review and data modeling. We reviewed the records of post-bone marrow transplantation patients who were newly diagnosed with ocular GVHD and initiated therapy, and analyzed changes in symptoms (Ocular Surface Disease Index [OSDI]; Symptom Assessment in Dry Eye [SANDE]) and signs (corneal fluorescein staining [CFS]; Schirmer test)...
July 2018: Ocular Surface
Di Chen, Afsun Sahin, Wendy R Kam, Yang Liu, Raheleh Rahimi Darabad, David A Sullivan
PURPOSE: Lipopolysaccharide (LPS), a bacterial endotoxin, is known to stimulate leuokotriene B4 (LTB4) secretion by human corneal (HCECs), conjunctival (HConjECs) and meibomian gland (HMGECs) epithelial cells. We hypothesize that this LTB4 effect represents an overall induction of proinflammatory gene expression in these cells. Our objective was to test this hypothesis. METHODS: Immortalized HCECs, HConjECs and HMGECs were cultured in the presence or absence of LPS (15 μg/ml) and ligand binding protein (LBP; 150 ng/ml)...
July 2018: Ocular Surface
Mackenzie Sward, Clayton Kirk, Sunita Kumar, Nabila Nasir, William Adams, Charles Bouchard
PURPOSE: Lax eyelid syndrome (LES) is defined as the association of distensible "floppy" eyelids and chronic papillary conjunctivitis. LES is also found in patients with obstructive sleep apnea (OSA) who have systemic elevation of inflammatory markers, including matrix metalloproteinases (MMP). Locally elevated MMP levels have also been demonstrated co-localized with elastin loss in eyelids of patients with LES, accounting for their "floppiness." The purpose of this study was to investigate tear film MMP levels and determine their association with eyelid laxity and OSA...
July 2018: Ocular Surface
Sridevi Nair, Murugesan Vanathi, Manoranjan Mahapatra, Tulika Seth, Jasbir Kaur, T Velpandian, Alok Ravi, Jeewan Singh Titiyal, Radhika Tandon
AIM: To analyze tear cytokines levels and their correlation to ocular surface parameters in allogenic hematopoietic stem cell transplants (allo-HSCT) patients. METHODS: Prospective longitudinal study of allo-HSCT patients and controls for ocular surface evaluation (OSDI, TBUT, Schirmer's test, staining scores), tear biochemical analysis for protein, cytokines [IL-10, IL-12, IL-2, IL-4, IL-6, IL-17, interferon (IFN)-gamma, tumor necrosis factor (TNF)-alpha, VEGF], MMPs [MMP 2, 9, 7, 13, 10 and chemokine (IL-8)], & VEGF on three consecutive follow up visits (at three monthly interval) was done...
July 2018: Ocular Surface
Ulrike Hampel, Fabian Garreis, Fabian Burgemeister, Nicole Eßel, Friedrich Paulsen
PURPOSE: The aim of this study was to establish and to evaluate an in vitro model for culturing human telomerase-immortalized corneal epithelial (hTCEpi) cells under adjustable medium flow mimicking the movements of the tear film on the ocular surface. METHODS: Using an IBIDI pump system, cells were cultured under unidirectional, continuous or oscillating, discontinuous medium flow. Cell surface and cytoskeletal architecture were investigated by scanning electron microscopy and immunofluorescence...
July 2018: Ocular Surface
Kwaku A Osei, Champion Deivanayagam, Jason J Nichols
Glycoprotein 340 (Gp340) is an innate immune receptor with well-defined roles in mucosal tissues. It is a normal component of mucosal fluids such as tears, breast milk, and saliva, and it is expressed in tissues such as the vagina, gastrointestinal tract, oral cavity, lung alveoli, and pancreas. In the eye, it is expressed in the lacrimal gland, cornea, conjunctiva, and retina. Investigations of the protein in wet-surfaced epithelia of the body show that the effects of Gp340 can be beneficial or harmful depending on the conformation in which it exists...
July 2018: Ocular Surface
R N Belfort, J Isenberg, A G Castillejos, R Sant'ana, A O Romano
PURPOSE: To evaluate the safety and 1-year effect of pattern scanning laser photocoagulation treatment for pedunculated papillomatous and sessile conjunctival lesions in a low-resource setting with extremely limited operating room access. METHODS: Adult patients with clinical diagnosis of conjunctival papilloma underwent complete ophthalmologic exam including anterior segment photography. After topical anesthesia and toluidine blue 1% instillation, the lesion was treated by pattern scanning photocoagulation using a duration time that varied from 20 to 100 ms and power from 600 to 1800 mW, treating the entire lesion surface with a 2 mm margin...
July 2018: Ocular Surface
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