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Ocular Surface

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https://www.readbyqxmd.com/read/29655617/novel-treatment-of-papillomatous-conjunctival-lesions-using-pattern-scanning-laser-photocoagulation-1-year-results
#1
R N Belfort, J Isenberg, A G Castillejos, R Sant'ana, A O Romano
PURPOSE: To evaluate the safety and 1-year effect of pattern scanning laser photocoagulation treatment for pedunculated papillomatous and sessile conjunctival lesions in a low-resource setting with extremely limited operating room access. METHODS: Adult patients with clinical diagnosis of conjunctival papilloma underwent complete ophthalmologic exam including anterior segment photography. After topical anesthesia and toluidine blue 1% instillation, the lesion was treated by pattern scanning photocoagulation using a duration time that varied from 20 to 100 ms and power from 600 to 1800 mW, treating the entire lesion surface with a 2 mm margin...
April 12, 2018: Ocular Surface
https://www.readbyqxmd.com/read/29627599/improving-the-practicality-and-safety-of-artificial-corneas-pre-assembly-and-gamma-rays-sterilization-of-the-boston-keratoprosthesis
#2
Miguel Gonzalez-Andrades, Roholah Sharifi, Mohammad-Mirazul Islam, Thibaut Divoux, Michael Haist, Eleftherios Paschalis, Larisa Gelfand, Shamina Mamodaly, Luca Di Cecilia, Andrea Cruzat, Franz-Josef Ulm, James Chodosh, Francois Delori, Claes H Dohlman
PURPOSE: To make the Boston keratoprosthesis (B-KPro), together with its carrier corneal graft, more easily procured, transported and stored, as well as less expensive, easier for the surgeon to implant and safer for the patient, it is proposed that the B-KPro-graft combination be pre-assembled by an expert technician, followed by sterilization with gamma ray irradiation (GI) allowing long-term storage at room temperature. For this to be possible, it must be shown that the B-KPro itself (not only the graft) remains unharmed by the irradiation...
April 5, 2018: Ocular Surface
https://www.readbyqxmd.com/read/29625303/ocular-chronic-graft-versus-host-disease-after-allogeneic-hematopoietic-stem-cell-transplantation-in-an-italian-referral-center
#3
Luigi Berchicci, Alessandro Rabiolo, Alessandro Marchese, Lorenzo Iuliano, Carmen Gigliotti, Elisabetta Miserocchi, Francesco Bandello, Giulio Modorati
PURPOSE: This study aimed to assess the prevalence and clinical manifestations of ocular graft-versus-host disease (GVHD) after allogeneic hematopoietic stem cell transplantation (allo-HSCT). METHODS AND METHODS: 269 patients who received allo-HSCT for hematologic malignancies were evaluated between December 2013 and April 2017 in this prospective observational study. Subjects underwent ophthalmologic examination at 6, 12 and 24 months after allo-HSCT. We evaluated the ophthalmologic and hematological data using the NIH consensus criteria definition and the International Chronic Ocular GVHD Consensus Group scoring systems...
April 3, 2018: Ocular Surface
https://www.readbyqxmd.com/read/29601983/corneal-lymphangiogenesis-facilitates-ocular-surface-inflammation-and-cell-trafficking-in-dry-eye-disease
#4
Yong Woo Ji, Jae Lim Lee, Hyun Goo Kang, Nayeong Gu, Haewon Byun, Areum Yeo, Hyemi Noh, Soyoung Kim, Eun Young Choi, Jong Suk Song, Hyung Keun Lee
PURPOSE: While the normal cornea has limited innervation by the lymphatic system, chronic immune-inflammatory disorders such as dry eye (DE) can induce lymphangiogenesis in the ocular surface. Using a conditional knock-down murine model, Lyve-1Cre ;VEGFR2flox mice, this study investigated the role of lymphangiogenesis in the pathophysiology of DE. METHODS: DE was induced in both wild type (WT) B6 and Lyve-1Cre ;VEGFR2flox mice. Tissue immunostaining and volumetric gross measurements were used to assess changes in the ocular surface, skin, and lymph nodes (LNs)...
March 27, 2018: Ocular Surface
https://www.readbyqxmd.com/read/29597010/boston-keratoprosthesis-type-1-for-limbal-stem-cell-deficiency-after-severe-chemical-corneal-injury-a-systematic-review
#5
REVIEW
Swapna S Shanbhag, Hajirah N Saeed, Eleftherios I Paschalis, James Chodosh
PURPOSE: To systematically review the published literature on outcomes of Boston keratoprosthesis type 1 for the treatment of limbal stem cell deficiency secondary to severe chemical corneal injury. METHODS: Literature searches were conducted in MEDLINE (Ovid), Embase, Web of Science, and the Cochrane Central Register. The main outcome measures assessed were the proportion of eyes with best-corrected visual acuity (BCVA) ≥ 20/200 and the proportion retaining their original keratoprosthesis, both at the last recorded visit...
March 26, 2018: Ocular Surface
https://www.readbyqxmd.com/read/29574281/the-significance-of-meibomian-gland-changes-in-asymptomatic-children
#6
Yinying Zhao, Siping Chen, Shangrong Wang, Yan Chen, Junhua Li, Yana Fu, Qi Dai, Xiaolei Lin, Yue Wu, Yune Zhao
PURPOSE: To evaluate meibomian gland morphology and function in children without ocular discomfort or pathology. METHOD: A total of 266 eyes of 266 children without signs or symptoms of ocular surface dysfunction were enrolled. Morphology of meibomian glands (MG) and non-invasive break-up time (BUT) was assessed by noncontact meibography. Based on lipid layer thickness (LLT) of the tear film measurements, 66 children were chosen to be assessed by meibomian glands yielding liquid secretion (MGYLS)...
March 21, 2018: Ocular Surface
https://www.readbyqxmd.com/read/29572164/surgical-management-of-severe-ocular-surface-injury-due-to-roman-candle-explosion-accidents
#7
Albert Y Cheung, Brad M Genereux, Brittney Dautremont, Amit Govil, Edward J Holland
PURPOSE: To report the clinical features, management, and outcomes of patients with ocular surface damage secondary to Roman candle explosion accidents. METHODS: Retrospective, noncomparative, interventional case series of 11 patients with Roman candle explosion-related ocular surface injuries referred to the Cincinnati Eye Institute between 2007 and 2016. RESULTS: Eleven patients (10 male, 1 female, mean age 22.4 years) sustained unilateral ocular surface injuries with presenting visual acuity ranging from count fingers to light perception...
March 20, 2018: Ocular Surface
https://www.readbyqxmd.com/read/29534924/genetic-factors-and-molecular-mechanisms-in-dry-eye-disease
#8
REVIEW
Ling Lee, Qian Garrett, Judith Flanagan, Subhabrata Chakrabarti, Eric Papas
Dry eye disease (DED) is a complex condition with a multifactorial etiology that can be difficult to manage successfully. While external factors are modifiable, treatment success is limited if genetic factors contribute to the disease. The purpose of this review is to compile research describing normal and abnormal ocular surface function on a molecular level, appraise genetic studies involving DED or DED-associated diseases, and introduce the basic methods used for conducting genetic epidemiology studies.
March 10, 2018: Ocular Surface
https://www.readbyqxmd.com/read/29510226/exploring-topical-anti-glaucoma-medication-effects-on-the-ocular-surface-in-the-context-of-the-current-understanding-of-dry-eye
#9
Aaron B C Wong, Michael T M Wang, Kevin Liu, Zak J Prime, Helen V Danesh-Meyer, Jennifer P Craig
PURPOSE: To assess tear film parameters, ocular surface characteristics, and dry eye symptomology in patients receiving topical anti-glaucoma medications. METHODS: Thirty-three patients with a diagnosis of open angle glaucoma or ocular hypertension, receiving unilateral topical anti-glaucoma medication for at least 6 months, were recruited in a cross-sectional, investigator-masked, paired-eye comparison study. Tear film parameters, ocular surface characteristics, and dry eye symptomology of treated and fellow eyes were evaluated and compared...
March 3, 2018: Ocular Surface
https://www.readbyqxmd.com/read/29510225/effects-of-environment-pollution-on-the-ocular-surface
#10
REVIEW
Se Ji Jung, Jodhbir Mehta, Louis Tong
The twenty-first century is fraught with dangers like climate change and pollution, which impacts human health and mortality. As levels of pollution increase, respiratory illnesses and cardiovascular ailments become more prevalent. Less understood are the eye-related complaints, which are commonly associated with increasing pollution. Affected people may complain of irritation, redness, foreign body sensation, tearing, and blurring of vision. Sources of pollution are varied, ranging from gases (such as ozone and NO2 ) and particulate matter produced from traffic, to some other hazards associated with indoor environments...
March 3, 2018: Ocular Surface
https://www.readbyqxmd.com/read/29501483/comparison-of-long-term-results-between-osteo-odonto-keratoprosthesis-and-tibial-bone-keratoprosthesis
#11
Victor Charoenrook, Ralph Michael, Maria Fideliz de la Paz, José Temprano, Rafael I Barraquer
PURPOSE: To compare the anatomical and the functional results between osteo-odonto-keratoprosthesis (OOKP) and keratoprosthesis using tibial bone autograft (Tibial bone KPro). METHODS: We reviewed the charts of 258 patients; 145 had OOKP whereas 113 had Tibial bone KPro implanted. Functional success was defined as best corrected visual acuity ≥0.05 on decimal scale and anatomical success as retention of the keratoprosthesis lamina. Kaplan-Meier survival curves were calculated for anatomical and functional survival as well as to estimate the probability of post-op complications...
February 28, 2018: Ocular Surface
https://www.readbyqxmd.com/read/29481958/erratum-to-tear-cytokine-profile-of-glaucoma-patients-treated-with-preservative-free-or-preserved-latanoprost
#12
Jose M Martinez-de-la-Casa, Francisco Perez-Bartolome, Elena Urcelay, Jose L Santiago, Javier Moreno-Montanes, Pedro Arriola-Villalobos, Jose M Benitez-Del-Castillo, Julian Garcia-Feijoo
No abstract text is available yet for this article.
February 23, 2018: Ocular Surface
https://www.readbyqxmd.com/read/29425812/assessment-of-the-prosthetic-replacement-of-ocular-surface-ecosystem-prose-scleral-lens-on-visual-acuity-for-corneal-irregularity-and-ocular-surface-disease
#13
Andres Parra, Bryan M Roth, Taylor M Nguyen, Li Wang, Stephen C Pflugfelder, Zaina Al-Mohtaseb
PURPOSE: To describe changes in visual acuity in patients fit with the Prosthetic Replacement of Ocular Surface Ecosystem (PROSE) with irregular corneas compared to those with ocular surface disease, as well as describe patient demographics and fitting indications for PROSE at an academic medical center. METHODS: A retrospective chart review from 2010 to 2016 on a total of 825 eyes from 493 patients fitted with a PROSE lens, and grouped by etiology, either irregular cornea/dystrophy or ocular surface disease and associated sub-etiologies...
February 6, 2018: Ocular Surface
https://www.readbyqxmd.com/read/29548808/to-be-biased-is-to-be-human
#14
EDITORIAL
Ali Djalilian
No abstract text is available yet for this article.
April 2018: Ocular Surface
https://www.readbyqxmd.com/read/29452252/compared-to-what-the-placebo-effect-in-dry-eye-therapy
#15
LETTER
Gary D Novack
No abstract text is available yet for this article.
April 2018: Ocular Surface
https://www.readbyqxmd.com/read/29409963/web-based-longitudinal-remote-assessment-of-dry-eye-symptoms
#16
Francisco Amparo, Reza Dana
PURPOSE: To investigate the feasibility of remote assessment and follow-up of dry eye symptoms using electronic versions of two validated questionnaires. METHODS: We conducted a prospective study of consecutive patients with dry eye disease (DED). Patients were enrolled during a clinical visit and were explained how to respond electronic versions of the Ocular surface Disease Index (OSDI) and the Symptom Assessment in Dry Eye (SANDE) questionnaires using a computer in the presence of investigators...
April 2018: Ocular Surface
https://www.readbyqxmd.com/read/29317327/sex-differences-in-clinical-characteristics-of-dry-eye-disease
#17
Jelle Vehof, Nicole Sillevis Smitt-Kamminga, Simone A Nibourg, Christopher J Hammond
PURPOSE: To investigate the role of sex on the symptomatology of DED and on the associations between symptoms and signs. METHODS: A cross-sectional study was used including 755 dry eye patients from the Groningen Longitudinal Sicca Study (GLOSSY cohort). Patient symptoms were assessed by the Ocular Surface Disease Index (OSDI) questionnaire and dry eye signs by the six most commonly used tests. Patients were divided in groups based on overall severity of signs and within these groups total and specific symptoms were compared by sex...
April 2018: Ocular Surface
https://www.readbyqxmd.com/read/29309844/development-of-an-in-vitro-model-to-study-the-biological-effects-of-blinking
#18
Guoting Qin, Hasna Baidouri, Adrian Glasser, VijayKrishna Raghunathan, Carol Morris, Inna Maltseva, Alison M McDermott
PURPOSE: To develop a mechanical model in which a contact lens is swept over ocular surface cells under conditions that mimic the force and speed of the blink, and to investigate the resulting biological changes. METHODS: A computer controlled mechanical instrument was developed to hold a dish containing 3D cultured stratified human ocular surface epithelial cells, across which an arm bearing a contact lens was swept back and forth repeatedly at a speed and force mimicking the human blink...
April 2018: Ocular Surface
https://www.readbyqxmd.com/read/29306088/changes-in-in-vivo-confocal-microscopic-findings-of-ocular-surface-squamous-neoplasia-during-treatment-with-topical-interferon-alfa-2b
#19
Mehran Zarei-Ghanavati, Ebrahim Mousavi, Amin Nabavi, Golshan Latifi, Hadi Z Mehrjardi, Masoomeh Mohebbi, Hamed Ghassemi, Farrin Mirzaie, Mohammad Ali Zare
PURPOSE: To evaluate in vivo confocal microscopy (IVCM) findings of ocular surface squamous neoplasia (OSSN) during treatment with topical interferon alfa-2b (IFN alfa-2b). METHODS: In this prospective interventional case series, 20 eyes from 20 patients with OSSN were treated with topical IFN alfa-2b 3 million IU/mL four times a day. Treatment was continued for 2 or 3 months after clinical resolution. IVCM was done at baseline, on a monthly basis, and at the end of treatment...
April 2018: Ocular Surface
https://www.readbyqxmd.com/read/29305292/corneal-nerve-regeneration-after-herpes-simplex-keratitis-a-longitudinal-in-vivo-confocal-microscopy-study
#20
Hamid-Reza Moein, Ahmad Kheirkhah, Rodrigo T Muller, Andrea C Cruzat, Deborah Pavan-Langston, Pedram Hamrah
PURPOSE: To evaluate the long-term alterations of corneal nerves in patients with herpes simplex virus (HSV) keratitis using in vivo confocal microscopy (IVCM). DESIGN: Prospective, longitudinal, cross sectional. METHODS: This study included 16 patients with a history of HSV keratitis and 15 age-matched normal controls. Slit-scanning IVCM was performed in all subjects at baseline and then after a mean follow-up of 37.3 ± 1.7 months in the patient group...
April 2018: Ocular Surface
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