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Ocular Surface

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https://www.readbyqxmd.com/read/29908870/current-and-upcoming-therapies-for-corneal-neovascularization
#1
REVIEW
Danial Roshandel, Medi Eslani, Alireza Baradaran-Rafii, Albert Y Cheung, Khaliq Kurji, Sayena Jabbehdari, Alejandra Maiz, Setareh Jalali, Ali R Djalilian, Edward J Holland
The cornea is unique because of its complete avascularity. Corneal neovascularization (CNV) can result from a variety of etiologies including contact lens wear; corneal infections; and ocular surface diseases due to inflammation, chemical injury, and limbal stem cell deficiency. Management is focused primarily on the etiology and pathophysiology causing the CNV and involves medical and surgical options. Because inflammation is a key factor in the pathophysiology of CNV, corticosteroids and other anti-inflammatory medications remain the mainstay of treatment...
June 14, 2018: Ocular Surface
https://www.readbyqxmd.com/read/29883739/impact-of-blinking-on-ocular-surface-and-tear-film-parameters
#2
Michael T M Wang, Leslie Tien, Alicia Han, Jung Min Lee, Dabin Kim, Maria Markoulli, Jennifer P Craig
PURPOSE: To investigate the influence of blinking on tear film parameters, ocular surface characteristics, and dry eye symptomology. METHODS: A total of 154 participants were recruited in an age, gender and ethnicity-matched cross-sectional study, of which 77 exhibited clinically detectable incomplete blinking, and 77 did not. Blink rate, dry eye symptomology, tear film parameters, and ocular surface characteristics were assessed in a single clinical session. RESULTS: Overall, a higher proportion of participants exhibiting incomplete blinking fulfilled the TFOS DEWS II dry eye diagnostic criteria (64% versus 44%, p = 0...
June 5, 2018: Ocular Surface
https://www.readbyqxmd.com/read/29883738/a-new-scale-for-the-assessment-of-conjunctival-bulbar-redness
#3
Ilaria Macchi, Vatinee Y Bunya, Mina Massaro-Giordano, Richard A Stone, Maureen G Maguire, Yuanjie Zheng, Min Chen, James Gee, Eli Smith, Ebenezer Daniel
PURPOSE: Current scales for assessment of bulbar conjunctival redness have limitations for evaluating digital images. We developed a scale suited for evaluating digital images and compared it to the Validated Bulbar Redness (VBR) scale. METHODS: From a digital image database of 4889 color corrected bulbar conjunctival images, we identified 20 images with varied degrees of redness. These images, ten each of nasal and temporal views, constitute the Digital Bulbar Redness (DBR) scale...
June 5, 2018: Ocular Surface
https://www.readbyqxmd.com/read/29883737/the-evaluation-of-dry-eye-mobile-apps-for-screening-of-dry-eye-disease-and-educational-tear-event-in-japan
#4
Miki Uchino, Motoko Kawashima, Yuichi Uchino, Natume Suzuki, Hiroto Mitamura, Miki Mizuno, Yuichi Hori, Norihiko Yokoi, Kazuo Tsubota
PURPOSE: To evaluate the usefulness of a dry eye mobile application (app) for screening dry eye disease (DED) at educational tear events in Japan. METHODS: In this cross-sectional study, Japanese subjects visiting a "Tears Day" event were selected randomly. They completed questionnaires and underwent ophthalmic evaluations for DED (using Japanese revised diagnostic criteria) including a functional visual acuity (FVA) test. The app calculated FVA using the average of the continuous VA over 30 s...
June 5, 2018: Ocular Surface
https://www.readbyqxmd.com/read/29802892/publishing-research-that-moves-the-field-forward
#5
EDITORIAL
Ali Djalilian
No abstract text is available yet for this article.
May 23, 2018: Ocular Surface
https://www.readbyqxmd.com/read/29800751/how-a-drug-developer-thinks-about-a-new-ophthalmic-product
#6
LETTER
Gary D Novack
No abstract text is available yet for this article.
May 22, 2018: Ocular Surface
https://www.readbyqxmd.com/read/29777869/subconjunctival-dendrimer-drug-therapy-for-the-treatment-of-dry-eye-in-rabbits-with-induced-autoimmune-dacryoadenitis
#7
Hui Lin, Ying Liu, Siva P Kambhampati, Chih-Chien Hsu, Rangaramanujam M Kannan, Samuel C Yiu
PURPOSE: To investigate the efficacy of a single subconjunctival injection of dendrimer-dexamethasone to treat dry eye in a rabbit model of induced autoimmune dacryoadenitis (AID). METHOD: Dendrimer biodistribution after subconjuntival injection in AID animals was evaluated using Cy5-labelled dendrimer (D-Cy5) and confocal microscopy. Diseased animals were treated with free dexamethasone (Free-Dex), dendrimer-dexamethasone (D-Dex), or saline via a single subconjunctival injection...
May 16, 2018: Ocular Surface
https://www.readbyqxmd.com/read/29772277/severity-therapeutic-and-activity-tear-biomarkers-in-dry-eye-disease-a-clinical-trial-sub-analysis
#8
José Pinto-Fraga, Amalia Enríquez-de-Salamanca, Margarita Calonge, María J González-García, Alberto López-Miguel, Alberto López-de la Rosa, Carmen García-Vázquez, Virginia Calder, Michael E Stern, Itziar Fernández
PURPOSE: To evaluate the effect of 0.1%-fluorometholone (FML) on tear inflammatory molecule levels after 22-days treatment in dry eye disease (DED) patients exposed to an adverse controlled environment (ACE), identifying different biomarkers. METHODS: Sub-analysis of a double-masked randomized clinical trial. Forty-one DED patients received 4-drops daily of topical FML (FML-group) or polyvinyl-alcohol (PA-group) for 22 days. At day 21, patients were exposed to an ACE...
May 14, 2018: Ocular Surface
https://www.readbyqxmd.com/read/29763694/corneal-fluorescein-staining-and-ocular-symptoms-but-not-schirmer-test-are-useful-as-indicators-of-response-to-treatment-in-chronic-ocular-gvhd
#9
Francisco Amparo, Hasanain Shikari, Ujwala Saboo, Reza Dana
PURPOSE: To evaluate long-term ocular surface clinical signs and symptoms response to therapy in patients with chronic ocular GVHD. METHODS: Retrospective review and data modeling. We reviewed the records of post-bone marrow transplantation patients who were newly diagnosed with ocular GVHD and initiated therapy, and analyzed changes in symptoms (Ocular Surface Disease Index [OSDI]; Symptom Assessment in Dry Eye [SANDE]) and signs (corneal fluorescein staining [CFS]; Schirmer test)...
May 12, 2018: Ocular Surface
https://www.readbyqxmd.com/read/29763693/influence-of-lipopolysaccharide-on-proinflammatory-gene-expression-in-human-corneal-conjunctival-and-meibomian-gland-epithelial-cells
#10
Di Chen, Afsun Sahin, Wendy R Kam, Yang Liu, Raheleh Rahimi Darabad, David A Sullivan
PURPOSE: Lipopolysaccharide (LPS), a bacterial endotoxin, is known to stimulate leuokotriene B4 (LTB4) secretion by human corneal (HCECs), conjunctival (HConjECs) and meibomian gland (HMGECs) epithelial cells. We hypothesize that this LTB4 effect represents an overall induction of proinflammatory gene expression in these cells. Our objective was to test this hypothesis. METHODS: Immortalized HCECs, HConjECs and HMGECs were cultured in the presence or absence of LPS (15 μg/ml) and ligand binding protein (LBP; 150 ng/ml)...
May 12, 2018: Ocular Surface
https://www.readbyqxmd.com/read/29729418/lax-eyelid-syndrome-les-obstructive-sleep-apnea-osa-and-ocular-surface-inflammation
#11
Mackenzie Sward, Clayton Kirk, Sunita Kumar, Nabila Nasir, William Adams, Charles Bouchard
No abstract text is available yet for this article.
May 2, 2018: Ocular Surface
https://www.readbyqxmd.com/read/29723628/tear-inflammatory-mediators-and-protein-in-eyes-of-post-allogenic-hematopoeitic-stem-cell-transplant-patients
#12
Sridevi Nair, Murugesan Vanathi, Manoranjan Mahapatra, Tullika Seth, Jasbir Kaur, T Velpandian, Alok Ravi, Jeevan Singh Titiyal, Radhika Tandon
AIM: To analyze tear cytokines levels and their correlation to ocular surface parameters in allogenic hematopoietic stem cell transplants (allo-HSCT) patients. METHODS: Prospective longitudinal study of allo-HSCT patients and controls for ocular surface evaluation (OSDI, TBUT, Schirmer's test, staining scores), tear biochemical analysi for protein, cytokines [IL-10, IL-12, IL-2, IL-4, IL-6, IL-17, interferon (IFN)-gamma, tumor necrosis factor (TNF)-alpha, VEGF], MMPs [MMP 2, 9, 7, 13, 10 and chemokine (IL-8)], & VEGF on three consecutive follow up visits (at three monthly interval) was done...
April 30, 2018: Ocular Surface
https://www.readbyqxmd.com/read/29709661/effect-of-intermittent-shear-stress-on-corneal-epithelial-cells-using-an-in-vitro-flow-culture-model
#13
Ulrike Hampel, Fabian Garreis, Fabian Burgemeister, Nicole Eßel, Friedrich Paulsen
PURPOSE: The aim of this study was to establish and to evaluate an in vitro model for culturing human telomerase-immortalized corneal epithelial (hTCEpi) cells under adjustable medium flow mimicking the movements of the tear film on the ocular surface. METHODS: Using an IBIDI pump system, cells were cultured under unidirectional, continuous or oscillating, discontinuous medium flow. Cell surface and cytoskeletal architecture were investigated by scanning electron microscopy and immunofluorescence...
April 27, 2018: Ocular Surface
https://www.readbyqxmd.com/read/29705554/glycoprotein-340-in-mucosal-immunity-and-ocular-surface
#14
REVIEW
Kwaku A Osei, Champion Deivanayagam, Jason J Nichols
Glycoprotein 340 (Gp340) is an innate immune receptor with well-defined roles in mucosal tissues. It is a normal component of mucosal fluids such as tears, breast milk, and saliva, and it is expressed in tissues such as the vagina, gastrointestinal tract, oral cavity, lung alveoli, and pancreas. In the eye, it is expressed in the lacrimal gland, cornea, conjunctiva, and retina. Investigations of the protein in wet-surfaced epithelia of the body show that the effects of Gp340 can be beneficial or harmful depending on the conformation in which it exists...
April 26, 2018: Ocular Surface
https://www.readbyqxmd.com/read/29655617/novel-treatment-of-papillomatous-conjunctival-lesions-using-pattern-scanning-laser-photocoagulation-1-year-results
#15
R N Belfort, J Isenberg, A G Castillejos, R Sant'ana, A O Romano
PURPOSE: To evaluate the safety and 1-year effect of pattern scanning laser photocoagulation treatment for pedunculated papillomatous and sessile conjunctival lesions in a low-resource setting with extremely limited operating room access. METHODS: Adult patients with clinical diagnosis of conjunctival papilloma underwent complete ophthalmologic exam including anterior segment photography. After topical anesthesia and toluidine blue 1% instillation, the lesion was treated by pattern scanning photocoagulation using a duration time that varied from 20 to 100 ms and power from 600 to 1800 mW, treating the entire lesion surface with a 2 mm margin...
April 12, 2018: Ocular Surface
https://www.readbyqxmd.com/read/29627599/improving-the-practicality-and-safety-of-artificial-corneas-pre-assembly-and-gamma-rays-sterilization-of-the-boston-keratoprosthesis
#16
Miguel Gonzalez-Andrades, Roholah Sharifi, Mohammad-Mirazul Islam, Thibaut Divoux, Michael Haist, Eleftherios Paschalis, Larisa Gelfand, Shamina Mamodaly, Luca Di Cecilia, Andrea Cruzat, Franz-Josef Ulm, James Chodosh, Francois Delori, Claes H Dohlman
PURPOSE: To make the Boston keratoprosthesis (B-KPro), together with its carrier corneal graft, more easily procured, transported and stored, as well as less expensive, easier for the surgeon to implant and safer for the patient, it is proposed that the B-KPro-graft combination be pre-assembled by an expert technician, followed by sterilization with gamma ray irradiation (GI) allowing long-term storage at room temperature. For this to be possible, it must be shown that the B-KPro itself (not only the graft) remains unharmed by the irradiation...
April 5, 2018: Ocular Surface
https://www.readbyqxmd.com/read/29625303/ocular-chronic-graft-versus-host-disease-after-allogeneic-hematopoietic-stem-cell-transplantation-in-an-italian-referral-center
#17
Luigi Berchicci, Alessandro Rabiolo, Alessandro Marchese, Lorenzo Iuliano, Carmen Gigliotti, Elisabetta Miserocchi, Francesco Bandello, Giulio Modorati
PURPOSE: This study aimed to assess the prevalence and clinical manifestations of ocular graft-versus-host disease (GVHD) after allogeneic hematopoietic stem cell transplantation (allo-HSCT). METHODS AND METHODS: 269 patients who received allo-HSCT for hematologic malignancies were evaluated between December 2013 and April 2017 in this prospective observational study. Subjects underwent ophthalmologic examination at 6, 12 and 24 months after allo-HSCT. We evaluated the ophthalmologic and hematological data using the NIH consensus criteria definition and the International Chronic Ocular GVHD Consensus Group scoring systems...
April 3, 2018: Ocular Surface
https://www.readbyqxmd.com/read/29601983/corneal-lymphangiogenesis-facilitates-ocular-surface-inflammation-and-cell-trafficking-in-dry-eye-disease
#18
Yong Woo Ji, Jae Lim Lee, Hyun Goo Kang, Nayeong Gu, Haewon Byun, Areum Yeo, Hyemi Noh, Soyoung Kim, Eun Young Choi, Jong Suk Song, Hyung Keun Lee
PURPOSE: While the normal cornea has limited innervation by the lymphatic system, chronic immune-inflammatory disorders such as dry eye (DE) can induce lymphangiogenesis in the ocular surface. Using a conditional knock-down murine model, Lyve-1Cre ;VEGFR2flox mice, this study investigated the role of lymphangiogenesis in the pathophysiology of DE. METHODS: DE was induced in both wild type (WT) B6 and Lyve-1Cre ;VEGFR2flox mice. Tissue immunostaining and volumetric gross measurements were used to assess changes in the ocular surface, skin, and lymph nodes (LNs)...
March 27, 2018: Ocular Surface
https://www.readbyqxmd.com/read/29548808/to-be-biased-is-to-be-human
#19
EDITORIAL
Ali Djalilian
No abstract text is available yet for this article.
April 2018: Ocular Surface
https://www.readbyqxmd.com/read/29534924/genetic-factors-and-molecular-mechanisms-in-dry-eye-disease
#20
REVIEW
Ling Lee, Qian Garrett, Judith Flanagan, Subhabrata Chakrabarti, Eric Papas
Dry eye disease (DED) is a complex condition with a multifactorial etiology that can be difficult to manage successfully. While external factors are modifiable, treatment success is limited if genetic factors contribute to the disease. The purpose of this review is to compile research describing normal and abnormal ocular surface function on a molecular level, appraise genetic studies involving DED or DED-associated diseases, and introduce the basic methods used for conducting genetic epidemiology studies.
April 2018: Ocular Surface
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