journal
MENU ▼
Read by QxMD icon Read
search

Annals of Hepatology

journal
https://www.readbyqxmd.com/read/29735803/the-observed-effect-of-gastric-bypass-surgery-on-direct-acting-antiviral-treatment-a-case-report
#1
Elise J Smolders, Sophie B Willemse, Omar El-Sherif, Saye Khoo, David M Burger
Chronic hepatitis C virus (HCV) infection can be cured with treatment using direct-acting antivirals (DAAs). Although these drugs have been widely studied, information about certain special populations is missing. In this case report we describe a treatment-experienced patient with chronic HCV infection genotype 1b, treated with 150 mg/day simeprevir, 400 mg/day sofosbuvir, and 1,000 mg/ day ribavirin for 24 weeks, after a Roux-and-Y gastric bypass. At steady-state a pharmacokinetic curve was recorded of sofosbuvir, GS-331007, and simeprevir...
April 9, 2018: Annals of Hepatology
https://www.readbyqxmd.com/read/29735802/hcbp6-is-involved-in-the-development-of-hepatic-steatosis-induced-by-high-fat-diet-and-ccl4-in-rats
#2
Yong-Ping Zheng, Xian-Yang Zhong, Yu-Shu Huang, Can-Bin Zheng
INTRODUCTION AND AIM: Hepatitis C virus core-binding protein 6 (HCBP6) was previously found to be an hepatitis C virus corebinding protein, its biological function remains unclear. Our research aims to investigate the role of HCBP6 in the development of hepatic steatosis induced by high-fat diet and carbon tetrachloride (CCL4) in rats. MATERIAL AND METHODS: Eighteen Wistar rats were randomly allocated into 3 groups: control group, model group 1, and model group 2...
April 9, 2018: Annals of Hepatology
https://www.readbyqxmd.com/read/29735801/mucinous-cystic-neoplasm-of-the-liver-or-intraductal-papillary-mucinous-neoplasm-of-the-bile-duct-a-case-report-and-a-review-of-literature
#3
Lumir Kunovsky, Zdenek Kala, Roman Svaton, Vladimir Prochazka, Jan Mazanec, Jakub Husty, Petr Moravcik
Mucinous cystic neoplasm of the liver (MCN-L) and intraductal papillary mucinous neoplasm of the bile duct (IPMN-B) are diagnoses that were classified by the World Health Organization in 2010 as mucin-producing bile duct tumors of the hepatobiliary system. The preoperative differential diagnosis between these two entities is difficult; the presence of a communication with the bile duct is usually considered as a typical sign of IPMN-B. However, the presence of an ovarian-like stroma (OLS) has been established to define the diagnosis of MCN-L...
April 9, 2018: Annals of Hepatology
https://www.readbyqxmd.com/read/29735800/potential-molecular-targets-of-statins-in-the-prevention-of-hepatocarcinogenesis
#4
Ezequiel Ridruejo, Giselle Romero-Caími, María J Obregón, Diana Kleiman de Pisarev, Laura Alvarez
Hepatocellular carcinoma (HCC) represents 90% of liver tumors. Statins, may reduce the incidence of various tumors, including HCC. Antitumoral activities may be mediated by changes in transforming growth factor-beta (TGF-β1) and thyroid hormones (TH) regulation. AIM: The aim of our study is to establish the statins mechanism of action and the potential key molecules involved in an in vivo and in vitro HCC model. MATERIALS AND METHODS: We used two models: in vivo (in rats) using diethylnitrosamine (DEN) and hexachlorobenzene (HCB) to develop HCC, we analyzed cell proliferation parameters (proliferating cell nuclear antigen, PCNA) and cholesterol metabolism (hydroxy-methylglutaryl-CoA reductase, HMGCoAR)...
April 9, 2018: Annals of Hepatology
https://www.readbyqxmd.com/read/29735799/therapeutic-effect-of-hgf-on-nash-mice-through-hgf-c-met-and-jak2-stat3-signalling-pathway
#5
Ning Li, Zhangfeng Dou, Jinchun Liu, Bao Chai, Yue Li, Xiuqin An, Peiling Chu, Xiaolan Zhang
INTRODUCTION AND AIM: Hepatocyte growth factor (HGF) has been shown to ameliorate liver inflammation and fibrosis; however, the mechanism underlying its effects in non-alcoholic steatohepatitis (NASH) is unclear. This study aimed to analyse the relationship between the JAK2-STAT3 signalling pathway and the ameliorating effect of HGF on NASH. MATERIAL AND METHODS: Mice were fed a high-fat diet (HFD) for 16 weeks, and then plasma and hepatic tissues were collected...
April 9, 2018: Annals of Hepatology
https://www.readbyqxmd.com/read/29735798/thrombosis-of-the-portal-venous-system-in-cirrhotic-vs-non-cirrhotic-patients
#6
Vania Cruz-Ramón, Paulina Chinchilla-López, Oscar Ramírez-Pérez, Nancy E Aguilar-Olivos, Luis F Alva-López, Ericka Fajardo-Ordoñez, Ileana Acevedo-Silva, Patrick G Northup, Nicolas Intagliata, Stephen H Caldwell, Guadalupe Ponciano-Rodríguez, Xingshun Qi, Nahum Méndez-Sánchez
INTRODUCTION AND AIM: Thrombosis is a vascular disorder of the liver often associated with significant morbidity and mortality. Cirrhosis is a predisposing factor for portal venous system thrombosis. The aim of this study is to determine differences between cirrhotics and non-cirrhotics that develop thrombosis in portal venous system and to evaluate if cirrhosis severity is related to the development of portal venous system thrombosis. MATERIAL AND METHODS: We studied patients diagnosed with portal venous system thrombosis using contrast-enhanced computed tomography scan and doppler ultrasound at Medica Sur Hospital from 2012 to 2017...
April 9, 2018: Annals of Hepatology
https://www.readbyqxmd.com/read/29735797/modulatory-effect-of-dietary-inclusion-of-aegle-marmelos-fruits-against-cisplatin-induced-hepatotoxicity-in-wistar-rats
#7
Saket S Chandel, Mrunal Shirsat, Ram K Sahu, Siva S Nayak
INTRODUCTION AND AIM: Aegle marmelos is an important traditional herbal medicine used in India. The dietary inclusion of the plant has never exposed earlier for its hepatoprotective activity. This study aimed to investigate the modulator efficacy of dietary inclusion of Aegle marmelos against Cisplatin - induced hepatotoxicity in Wistar albino rats. MATERIAL AND METHODS: Animals were divided into five different groups; Group I was given basal diets only, Group II was fed basal diets with Aegle marmelos in 4% concentration, while Group III was fed basal diets co-administered with Cisplatin...
April 9, 2018: Annals of Hepatology
https://www.readbyqxmd.com/read/29735796/non-alcoholic-fatty-liver-disease-in-children-and-adolescents-lifestyle-change-a-systematic-review-and-meta-analysis
#8
Melina Utz-Melere, Cristina Targa-Ferreira, Bernardo Lessa-Horta, Matias Epifanio, Marialena Mouzaki, Angelo A Mattos
INTRODUCTION AND AIM: This manuscript seeks to analyze the impact of lifestyle changes on body mass index (BMI), aminotransferases and steatosis in children and adolescents with nonalcoholic fatty liver disease (NAFLD). MATERIALS AND METHODS: A review of PubMed, BIREME, Scopus, EMBASE, Medline and Web of Science databases 2015 was performed seeking studies addressing the impact of lifestyle interventions on children and/or adolescents with NAFLD. Inclusion were manuscripts written in Portuguese, English and Spanish, as well as age less than 18 years...
April 9, 2018: Annals of Hepatology
https://www.readbyqxmd.com/read/29735795/lncrna-regulated-autophagy-and-its-potential-role-in-drug-induced-liver-injury
#9
Juan Zhou, Yi Li, XinYu Liu, Yunzhu Long, Jun Chen
BACKGROUND AND AIM: Autophagy and its regulated pathways participate in many important cellular physiology and pathological processes involving protein aggregates, damaged mitochondria, excessive peroxisomes, ribosomes, and invading pathogens. This study aimed to review recently published studies and further describe the long noncoding RNA (lncRNA)-regulated autophagy during drug-induced liver injury (DILI). MATERIAL AND METHODS: DILI, autophagy, autophagy-related genes (ATGs), and lncRNA were used as key words to search published studies from PubMed, Google Scholar, and Web of Science...
April 9, 2018: Annals of Hepatology
https://www.readbyqxmd.com/read/29735794/the-presence-and-severity-of-nonalcoholic-steatohepatitis-is-associated-with-specific-changes-in-circulating-bile-acids
#10
Aline Gottlieb, Lars Bechmann, Ali Canbay
Non-alcoholic fatty liver disease (NAFLD) is the most common cause of chronic liver disease nowadays with currently no approved therapies for the disease. The liver plays a pivotal role in lipid and glucose metabolism. The interactions of molecular mechanisms on the gut for example influences the development still needs to be understood. Bile acids (BA) have been shown to impact metabolic homeostasis and insulin sensitivity. Here, we comment on a study analyzing BA profiles in NAFLD patients addressing novel pathways involved in NAFLD progression...
April 9, 2018: Annals of Hepatology
https://www.readbyqxmd.com/read/29735793/viewpoint-alcohol-consumption-in-late-adolescence-is-associated-with-an-increased-risk-of-severe-liver-disease-later-in-life
#11
Adriana Tamburello, Marco Marando, Stefano Bellentani
Drinking alcohol during adolescence predispose to severe liver disease in the adult phase. This is the main message of this prospective study. Each daily gram of alcohol men consumed in their youth was linked with a two percent increase in the risk of severe liver disease. No threshold level emerged for liver damage and this is a warning for all the sociologists and politics. New legiferation and educational campaigns addressed to young people, with particular attention to the access to alcohol, prices and advertising are necessary...
April 9, 2018: Annals of Hepatology
https://www.readbyqxmd.com/read/29735792/a-new-stage-in-annals-of-hepatology
#12
Arturo Panduro, Claudio Tiribelli, Norberto C Chávez-Tapia, Misael Uribe
No abstract text is available yet for this article.
April 9, 2018: Annals of Hepatology
https://www.readbyqxmd.com/read/29735791/vitamin-d-deficiency-is-not-associated-with-fatty-liver-in-a-mexican-population
#13
Fabiola López-Bautista, Carlos Posadas-Romero, Luz Y Ruiz-Vargas, Guillermo Cardoso-Saldaña, Juan G Juárez-Rojas, Aida Medina-Urrutia, Nonanzit Pérez-Hernández, José M Rodríguez-Pérez, Gilberto Vargas-Alarcón, Rosalinda Posadas-Sánchez
INTRODUCTION AND AIM: Association of vitamin D deficiency (VDD) with fatty liver (FL) disease is controversial. The purpose of this study was to analyze the association of VDD with FL. MATERIAL AND METHODS: Cross-sectional study. Data on cardiovascular risk factors, medications, alcohol intake, smoking, diet, and physical activity were obtained. Biochemical, anthropometric, and blood pressure variables were measured. The 25-hydroxyvitamin D (25(OH)D) was quantified through chemoluminescence...
April 9, 2018: Annals of Hepatology
https://www.readbyqxmd.com/read/29735790/comparison-of-dynamic-changes-among-various-prognostic-scores-in-viral-hepatitis-related-acute-liver-failure
#14
Shalimar -, Ujjwal Sonika, Saurabh Kedia, Soumya J Mahapatra, Baibaswata Nayak, Dawesh P Yadav, Deepak Gunjan, Bhaskar Thakur, Harpreet Kaur, Subrat K Acharya
INTRODUCTION AND AIM: Multiple prognostic scores are available for acute liver failure (ALF). Our objective was to compare the dynamicity of model for end stage liver disease (MELD), MELD-sodium, acute liver failure early dynamic model (ALFED), chronic liver failure (CLIF)-consortium ACLF score and King's College Hospital Criteria (KCH) for predicting outcome in ALF. MATERIALS AND METHODS: All consecutive patients with ALF at a tertiary care centre in India were included...
April 9, 2018: Annals of Hepatology
https://www.readbyqxmd.com/read/29735789/direct-acting-antivirals-improve-hcv-treatment-initiation-and-adherence-among-underserved-african-americans
#15
Kendall R Beck, Nicole J Kim, Mandana Khalili
INTRODUCTION: Adherence to hepatitis C (HCV) care was suboptimal in the interferon era among underserved African Americans (AA), but adherence data in the era of direct acting antivirals (DAA) is lacking in this population. We aimed to evaluate the impact of DAA on HCV care in underserved AA. MATERIAL AND METHODS: Clinical records of AAs undergoing HCV evaluation attending a safety net health system liver clinic were reviewed from 2006 to 2011 (pre-DAA), and January 1, 2014 to December 31, 2016 (post-DAA)...
April 9, 2018: Annals of Hepatology
https://www.readbyqxmd.com/read/29735788/association-between-hepatitis-c-virus-and-chronic-kidney-disease-a-systematic-review-and-meta-analysis
#16
Fabrizio Fabrizi, Francesca M Donato, Piergiorgio Messa
INTRODUCTION: The role of hepatitis C virus infection as a risk factor for the development and progression of chronic kidney disease in the general population remains unclear. MATERIAL AND METHODS: A systematic review of the published medical literature was performed to assess whether positive anti-HCV serologic status is associated with higher frequency of chronic kidney disease in the adult general population. We used a random-effects model to generate a summary estimate of the relative risk of chronic kidney disease (defined by lowered glomerular filtration rate or detectable proteinuria) with HCV across the published studies...
April 9, 2018: Annals of Hepatology
https://www.readbyqxmd.com/read/29735787/a-dynamic-model-for-predicting-outcome-in-patients-with-hbv-related-acute-on-chronic-liver-failure
#17
Wei Lin, Jing Zhang, Xiaohui Liu, Hongqun Liu, Jinqiu He, Ming Li, Shuqin Zhang, Yuexin Zhang, Hong Chen, Changqing Zhang, Wenfang Wu, Chenggang Jin, Samuel S Lee, Zhongping Duan
INTRODUCTION AND AIM: Accurately predicting the prognosis of individual patient is crucial in the management of ACLF. We aimed to establish a specific prognostic model for HBV-related ACLF patients treated with nucleoside analog (NA). MATERIAL AND METHODS: We prospectively collected 205 ACLF cases diagnosed according to the APASL criteria. A dynamic prognostic model based on APASL criteria was established and validated. To demonstrate that the model is also applicable to those within EASL criteria, we divided the patients into two groups: met APASL criteria only (group A, n = 123); met both APASL and EASL criteria (group B, n = 82)...
April 9, 2018: Annals of Hepatology
https://www.readbyqxmd.com/read/29735786/prognostic-significance-of-the-new-criteria-for-acute-kidney-injury-in-cirrhosis
#18
Emilia T O Bansho, Pedro Eduardo S Silva, Bruno S Colombo, Letícia M Wildner, Maria Luiza Bazzo, Esther B Dantas-Corrêa, Leonardo L Schiavon, Janaína L Narciso-Schiavon
BACKGROUND: New criteria for acute kidney injury (AKI) in cirrhosis have been proposed, but its prognostic significance is unclear. This study aims to evaluate the prognostic significance of the AKI criteria in cirrhotic patients hospitalized for acute decompensation. MATERIAL AND METHODS: This is a prospective cohort study. AKI was defined as an increase in creatinine (Cr) levels ≥ 0.3 mg/dL in 48 h or ≥ 50% of the basal value in the last 7d. AKI was divided into stages 1 (elevation: < 2x basal), 2 (2 or 3x), and 3 (> 3x)...
April 9, 2018: Annals of Hepatology
https://www.readbyqxmd.com/read/29735785/alcohol-consumption-influences-clinical-outcome-in-patients-admitted-to-a-referral-center-for-liver-disease
#19
Suyan G R Dos Santos, Angelo A Mattos, Marcela M Guimarães, Bibiana de S Boger, Gabriela P Coral
INTRODUCTION AND AIM: Excessive alcohol consumption is a public health concern worldwide and has been associated with high mortality rates. This study aimed to determine the prevalence of alcohol consumption and its influence on the prognosis of hospitalized cirrhotic patients in a tertiary care hospital. MATERIAL AND METHODS: We reviewed the medical records of all patients with hepatic cirrosis admitted between January 2009 and December 2014, in a referral center for liver disease in southern Brazil...
April 9, 2018: Annals of Hepatology
https://www.readbyqxmd.com/read/29735784/sofosbuvir-based-therapy-in-the-pre-liver-transplant-setting-the-canadian-national-experience
#20
Bandar Al-Judaibi, Benson Thomas, Philip Wong, Amine Benmassaoud, Jo-Hua Chen, M Katherine Dokus, Trana Hussaini, Marc Bilodeau, Kelly W Burak, Paul Marotta, Eric M Yoshida
INTRODUCTION AND AIM: Sofosbuvir (SOF)-based regimen has been shown to have high efficacy even in patients with decompensated cirrhosis. Treated patients may experience various degrees of hepatic recovery ranging from stabilization of liver function, to removal from liver transplant wait lists. The frequency of these occurrences in larger transplant eligible patient populations is unknown. The aim of this study was to assess the efficacy of SOF-based therapy in HCV infected transplant eligible patients and to evaluate short term changes in liver function and the effect on their liver transplant status...
April 9, 2018: Annals of Hepatology
journal
journal
40296
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"