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Annals of Hepatology

Tiffany Wu, Timothy R Morgan, Andrew S Klein, Michael L Volk, Sammy Saab, Vinay Sundaram
Alcoholic hepatitis (AH) is a condition of acute liver inflammation in the setting of heavy alcohol use that is often managed with corticosteroids in severe cases. Among non-responders to steroids, however, prognosis is poor with up to 75% mortality within 6 months after treatment failure. Early liver transplantation (LT) can achieve an acceptable short-term survival, and initial studies have demonstrated 3-year survival rates of up to 84%. However, the practice of early LT in severe AH remains controversial with concerns over the 6-month rule of sobriety and risk of alcohol relapse post-transplant...
August 24, 2018: Annals of Hepatology
Hong-Shan Li
INTRODUCTION AND AIM: Salidroside and curcumin (SC) formula could alleviate lipid deposition in high fat diet-induced nonalcoholic fatty liver disease (NAFLD). However, the mechanisms are still unknown, and the magnitude of potential therapeutic benefit remains understudied. MATERIAL AND METHODS: The rats were treated with high fat diet for 14 weeks to induce NAFLD. The experiment was divided into control, model (NAFLD), SC formula and rosiglitazone groups (n = 7 in each group)...
August 24, 2018: Annals of Hepatology
Judy A Trieu, Mohammad Bilal, Briana Lewis, Eric Gou, Lindsay Sonstein, Sreeram Parupudi
Malnutrition is a common cause of impeding recovery in patients with acute alcoholic hepatitis (AAH). Previous reports have shown that appropriate nutritional supplementation reduce short and long-term mortality in patients with AAH. Despite these clear recommendations, the element of nutrition in AAH is often neglected. We designed a quality improvement project to evaluate and improve compliance with appropriate nutrition in patients presenting with AAH at our institution. Patients admitted with AAH between December 2015 to December 2016 were included...
August 24, 2018: Annals of Hepatology
Mitsuyoshi Suzuki, Kei Minowa, Hitoshi Tajiri
Interferon-based simeprevir therapy showed high efficacy and tolerability in children with genotype 1 hepatitis C virus infection. While direct-acting antivirals (DAAs) therapy are undergoing study in children, this regimen is considered an available therapeutic option for selected patients in countries where DAAs have not yet been approved.
August 24, 2018: Annals of Hepatology
María Ángeles Otero, Chang-Hai Liu, Javier Ampuero, Rocío Llorca, Manuel Vargas-Romero, Manuel Romero-Gómez
INTRODUCTION AND AIM: The detection of hepatitis B virus (HBV) depends on primary care center activity. The present study aims to investigate the impact of peer-to-peer sessions with hepatologists on hepatitis B screening efficacy in primary care centers. MATERIAL AND METHODS: Peer-to-peer one-hour sessions were scheduled to improve the screening program for HBV in Seville, Spain. The sessions were focused on who should be tested for HBV and how positive cases should be referred...
August 24, 2018: Annals of Hepatology
Alberto López-Reyes, Denise Clavijo-Cornejo, Javier Fernández-Torres, Daniel Medina-Luna, Erendida G Estrada-Villaseñor, Luis E Gómez-Quiroz, Marwin Gutiérrez, Julio Granados, Gilberto Vargas-Alarcón, Carlos Pineda, Hiram García, Luis A Morales-Garza, María C Gutiérrez-Ruiz, Karina Martínez-Flores
INTRODUCTION AND AIM: Obesity is a worldwide epidemic problem, described as a risk factor for hepatic diseases, such as non-alcoholic fatty liver disease and other pathologies related to development of cholesterol crystals and cholesterol gallbladder stones. It has been reported that cholesterol overload may cause hepatic damage; however, little is known about the effects of an acute hypercholesterolemic diet on the gallbladder. The aim of this manuscript was to evaluate the impact of a cholesterol-rich diet on the gallbladder...
August 24, 2018: Annals of Hepatology
Yu-Ying Chang, Chia-Jui Yen, Shih-Huang Chan, Yi-Wen Chou, Yun-Ping Lee, Ching-Yu Bao, Chien-Jung Huang, Wenya Huang
INTRODUCTION AND AIM: Developing reliable biomarkers for hepatocellular carcinoma (HCC) patients who are at a high risk of recurrence after curative hepatic resection is very important for determining subsequent therapeutic strategies. We investigated the role of the cell cycle factor NIMA-related kinase 2 (NEK2) in HCC progression in hepatoma cells and post-surgery patients. MATERIAL AND METHODS: The effects of NEK2 on proliferation, invasion and migration of hepatoma HuH7 and SK-Hep1 cells were evaluated...
August 24, 2018: Annals of Hepatology
Ali A Alsaad, Fernando F Stancampiano, William C Palmer, April M Henry, Jillian K Jackson, Michael G Heckman, Nancy N Diehl, Andrew P Keaveny
INTRODUCTION AND AIMS: Serum electrolyte derangements are common in patients with decompensated cirrhosis hospitalized for hepatic encephalopathy. There are limited data describing the association between electrolyte levels and outcomes in hepatic encephalopathy. We assessed the association between initial serum electrolyte values and outcomes in patients with hepatic encephalopathy. MATERIAL AND METHODS: A total of 385 consecutive patients hospitalized with encephalopathy were included in the study...
August 24, 2018: Annals of Hepatology
Dimitrios Keramidaris, Stavros Gourgiotis, Antonella Koutela, Evgenios Mpairamidis, Christianna Oikonomou, Constantinos Villias, Alexios Rigas
Endometriosis is the abnormal existence of functional uterine mucosal tissue outside the uterus. It is a usual disorder of women in reproductive age which is mainly located in the female genital tract. Hepatic endometriosis is one of the rarest disorders characterized by the presence of ectopic endometrium in the liver. It is often described as cystic mass with or without solid component. Preoperative diagnosis is difficult via cross-sectional imaging and histopathologic evaluation remains the gold standard for diagnosis...
August 24, 2018: Annals of Hepatology
Gamal E Shiha, Shahira El-Etreby, Mounir Bahgat, Magdy Hamed, Mohamed El Sherbini, Elsayed A Ghoneem, Khaled Zalata, Reham E Soliman, Mohamed A El Basiouny, Nabiel Nh Mikhail
INTRODUCTION AND AIM: Transient elastography is gaining popularity as a non-invasive method for predicting liver fibrosis, but inter observer agreement and factors influencing reproducibility have not been adequately assessed. MATERIAL AND METHODS: This cross-sectional study was conducted at Specialized Medical Hospital and the Egyptian Liver Foundation, Mansoura, Egypt. The inclusion criteria were: age older than 18 years and chronic infection by hepatitis C. The exclusion criteria were the presence of ascites, pacemaker or pregnancy...
August 24, 2018: Annals of Hepatology
Wenxiu Yu, Hailin Yu, Jun Ling, Jiang Du, Zhijing Yin, Chengen Li, Min Zhou
Gastrointestinal foreign bodies are commonly encountered in clinical practice. However, although perforation of the gastrointestinal tract by a foreign body is not unusual, the formation of a hepatic abscess as a result of the migration of a foreign body is extremely rare. Patients usually present with atypical symptoms, and the treatment of such pyogenic liver abscesses presents a challenge. Here we report a case of hepatic abscess secondary to stomach perforation by a fish bone.
August 24, 2018: Annals of Hepatology
Yiting Liu, Wei Wang, Xiaosong Yu, Xingshun Qi
INTRODUCTION AND AIMS: The association between thyroid function and non-alcoholic fatty liver disease (NAFLD) remained controversial. A large cross-sectional study aimed to explore the relationship in euthyroid population. MATERIAL AND METHODS: A total of 1773 euthyroid subjects who underwent health check-up during one-year period were enrolled. NAFLD was diagnosed by ultrasound and fatty liver index (FLI). Fibrosis was estimated by BARD score. Thyroid function parameters, including thyroid-stimulating hormone (TSH), free triiodothyronine (FT3), and free thyroxine (FT4), were recorded...
August 24, 2018: Annals of Hepatology
Cheng-Hao Tseng, Chi-Yang Chang, Lein-Ray Mo, Jaw-Town Lin, Chi-Ming Tai, Daw-Shyong Perng, Chih-Wen Lin, Yao-Chun Hsu
INTRODUCTION AND AIM: In chronic hepatitis B (CHB) patients with equivocal indication for antiviral therapy, therapeutic decision currently depends on histopathology of the liver. We aimed to evaluate if acoustic radiation force impulse (ARFI) in conjunction with aspartate transaminase to platelet ratio index (APRI) and fibrosis-4 (FIB-4) score could replace liver biopsy to indicate treatment for CHB. MATERIAL AND METHODS: We prospectively enrolled 101 clinically non-cirrhotic patients whose serum alanine aminotransferase was mildly elevated (1-2 folds above the upper normal limit) despite a high viral load (HBV DNA > 2,000 IU/mL)...
August 24, 2018: Annals of Hepatology
James C Barton, Christine E McLaren, Wen-Pin Chen, Grant A Ramm, Gregory J Anderson, Lawrie W Powell, V Nathan Subramaniam, Paul C Adams, Pradyumna D Phatak, Lyle C Gurrin, John D Phillips, Charles J Parker, Mary J Emond, Gordon D McLaren
INTRODUCTION AND AIM: We sought to identify independent risk factors for cirrhosis in HFE p.C282Y homozygotes in a cross-sectional study. MATERIAL AND METHODS: We evaluated 368 p.C282Y homozygotes who underwent liver biopsy and compared characteristics of those with and without cirrhosis. We performed multivariable logistic regression on cirrhosis with: age; sex; race/ethnicity; diabetes; blood pints/units donated voluntarily; erythrocyte pints/units received; iron supplement use; alcohol intake, g/d; body mass index, kg/m2; swollen/tender 2nd/3rd metacarpophalangeal joints; elevated alanine aminotransferase; elevated aspartate aminotransferase; steatosis/fatty liver; iron removed by phlebotomy, g; and GNPAT p...
August 24, 2018: Annals of Hepatology
Bashar Aqel, Michael Leise, Hugo E Vargas, Kymberly D Watt, Andrew P Keaveny, Nan Zhang, Nan Zhang, Surakit Pungpapong
INTRODUCTION AND AIM: Approximately 10%-15% of patients with hepatitis C genotype 1 (HCV GT1) experience virological relapse after all-oral antiviral regimen using simeprevir (SMV) and sofosbuvir (SOF). The efficacy and safety of treating such relapsers using ledipasvir/sofosbuvir (LDV/SOF) with/without ribavirin (RBV) has been limited. OBJECTIVE: Report the virological response and safety of LDV/SOF with/without RBV for 12-24 weeks in treating HCV GT1 relapsers after SMV + SOF...
August 24, 2018: Annals of Hepatology
Clemens Heiser, Bernhard Haller, Maximilian Sohn, Benedikt Hofauer, Andreas Knopf, Tobias Mühling, Jessica Freiherr, Martin Bender, Maximilian Tiller, Anna Schmidt, Wolfgang Schepp, Felix Gundling
INTRODUCTION AND AIM: Olfactory functions are altered to a variable degree by chronic liver disease. Few studies including only small populations of patients emphasized the possibility of hepatic encephalopathy (HE) influencing olfactory nervous tasks. So far, no study has explicitly focused on olfactory function depending on the severity of HE as assessed by objective diagnostic procedures. Thus we performed a study using the "Sniffin' Sticks" test system, critical flicker-fusion frequency (CFF) and clinical West Haven criteria...
August 24, 2018: Annals of Hepatology
Vor Luvira, Supot Kamsa-Ard, Siriporn Kamsa-Ard, Varisara Luvira, Tharatip Srisuk, Ake Pugkhem, Chawalit Pairojkul, Vajarabhongsa Bhudhisawasdi
INTRODUCTION AND AIM: The carcinogenesis of tubular and papillary cholangiocarcinoma (CCA) differ. The available epidemiologic studies about risk factors for CCA do not differentiate between the tubular and papillary type. The current study investigated the relationship between the number of repeated use of Praziquantel (PZQ) treatments and each type of CCA. MATERIAL AND METHODS: This was a hospital-based, matched, case-control study of patients admitted to Srinagarind Hospital, Khon Kaen University...
August 24, 2018: Annals of Hepatology
Sumit Kumar, Ronak Modi, Bhavik M Bhandari, David A Sass, Kenneth D Rothstein
INTRODUCTION AND AIM: The evaluation to determine the cause of hepatic encephalopathy consists primarily of laboratory testing to rule out infections and metabolic causes. Despite lack of evidence, it is a common practice amongst clinicians to obtain a head CT as part of their initial evaluation in a cirrhotic presenting with recurrent episodes of hepatic encephalopathy. MATERIAL AND METHODS: Medical records of all cirrhotic adults admitted to a tertiary care hospital from 2007 to 2010 with hepatic encephalopathy were reviewed...
August 24, 2018: Annals of Hepatology
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