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Annals of Hepatology

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https://www.readbyqxmd.com/read/29894288/renovation-of-annals-of-hepatology-s-scientific-scope-towards-preventing-rather-than-treating-end-stage-liver-disease
#1
Arturo Panduro, Claudio Tiribelli, Norberto C Chávez-Tapia, Marco Arrese, Misael Uribe
No abstract text is available yet for this article.
July 2018: Annals of Hepatology
https://www.readbyqxmd.com/read/29893709/svr-24-achievement-two-weeks-after-a-tripled-dose-of-daclatasvir-in-an-hcv-genotype-3-patient
#2
Sara Lo Menzo, Enrico Biagi, Mariachiara Di Nuzzo, Anastasio Grilli, Carlo Contini
Directly-acting antivirals (DAA) have changed the chronic hepatitis C virus (HCV) infection therapeutic scenario allowing virus eradication in more than 95% of patients, independently from the genotype, with 12 to 24-week treatment regimens. We describe a 51-year-old Pakistani man with a chronic HCV-genotype 3 (GT3a) infection with moderate liver fibrosis, who achieved sustained virological response (SVR) 24 after a tripled dose of Daclatasvir (DCV) taken erroneously associated to Sofosbuvir (SOF). The patient had a concomitant intestinal TB infection whose treatment had been delayed in order to firstly eradicate HCV to reduce the liver toxicity of anti-mycobacterial drugs...
July 2018: Annals of Hepatology
https://www.readbyqxmd.com/read/29893708/rapamycin-combi-with-tae-on-the-growth-metastasis-and-prognosis-of-hepatocellular-carcinoma-in-rat-models
#3
Hong-Wei Lei, Jie Cai, Cheng-Ming Li, Fang Yang, Wan-Qing Shi, Wan-Qing Shi, Li-Ping Wang, You-Ying Feng
INTRODUCTION AND AIM: To investigate the effect of mTOR inhibitor Rapamycin combined with transcatheter arterial embolization (TAE) on the growth, metastasis, and prognosis of hepatocellular carcinoma (HCC) in rat model. MATERIAL AND METHOD: McARH7777 cells were used to construct rat models of HCC, which were randomly divided into Model, Rapamycin, TAE, and Rapamycin + TAE groups. Quantitative reverse transcription-PCR (qRT-PCR) and Western Blot were used to detect the expression of Epithelial-Mesenchymal Transition (EMT)-related molecules, and immunohistochemical staining to determine the expression of EMTrelated proteins, angiogenic factors as well as microvessel density (MVD)-CD34...
July 2018: Annals of Hepatology
https://www.readbyqxmd.com/read/29893707/undue-elevation-of-procalcitonin-in-pediatric-paracetamol-intoxication-is-not-explained-by-liver-cell-injury-alone
#4
Eva Tschiedel, Roland Assert, Ursula Felderhoff-Müser, Simone Kathemann, Oliver Witzke, Peter Hoyer, Christian Dohna-Schwake
INTRODUCTION AND AIM: Procalcitonin is widely used as a biomarker to distinguish bacterial infections from other etiologies of systemic inflammation. Little is known about its value in acute liver injury resulting from intoxication with paracetamol. MATERIAL AND METHODS: We performed a single-center retrospective analysis of the procalcitonin level, liver synthesis, liver cell damage and renal function of patients admitted with paracetamol-induced liver injury to a tertiary care children's hospital...
July 2018: Annals of Hepatology
https://www.readbyqxmd.com/read/29893706/hepatic-angiosarcoma-with-kasabach-merritt-phenomenon-a-case-report-and-review-of-the-literature
#5
Fumika Fujii, Takefumi Kimura, Naoki Tanaka, Daisuke Kubota, Ayumi Sugiura, Takeji Umemura, Shuichi Wada, Eiji Tanaka
A 76-year-old woman was referred to our hospital due to massive gingival bleeding following teeth extraction. Laboratory findings suggested disseminated intravascular coagulopathy (DIC). Enhanced computed tomography and magnetic resonance imaging disclosed multiple hypervascular liver masses of 2-6 cm in diameter, the largest of which displaying an irregular enhancement pattern. We considered that her DIC was caused by the multiple liver masses and commenced repeated erythrocyte/fresh frozen plasma infusión and gabexate mesilate administration...
July 2018: Annals of Hepatology
https://www.readbyqxmd.com/read/29893705/pattern-of-vascular-involvement-in-egyptian-patients-with-budd-chiari-syndrome-relation-to-etiology-and-impact-on-clinical-presentation
#6
Mohammad A Sakr, Sara M Abdelhakam, Hany M Dabbous, Ahmed S Abdelmoaty, Hend E Ebada, Wael M Al-Banna, Mohamed S Ghazy, Mohamed E Aboelmaaty, Ahmed K Eldorry
INTRODUCTION AND AIM: Budd-Chiari syndrome (BCS) is caused by hepatic venous outflow obstruction. This work aims to analyze the pattern of vascular involvement in Egyptian patients with BCS, demonstrates its relation to etiology and shows its impact on clinical presentation. MATERIAL AND METHODS: The current retrospective study was conducted at The Tropical Medicine Department, Ain Shams University on one hundred Egyptian patients with confirmed diagnosis of primary BCS who were presented to the Budd-Chiari Study Group (BCSG) from April 2014 to May 2016 by collecting clinical, laboratory and radiological data from their medical records...
July 2018: Annals of Hepatology
https://www.readbyqxmd.com/read/29893704/association-between-low-testosterone-levels-and-sarcopenia-in-cirrhosis-a-cross-sectional-study
#7
Carlos Moctezuma-Velázquez, Gavin Low, Marina Mourtzakis, Mang Ma, Kelly W Burak, Puneeta Tandon, Aldo J Montano-Loza
INTRODUCTION AND AIM: Sarcopenia is an independent predictor of mortality in cirrhosis. Hypogonadism is common in cirrhosis and has been associated with sarcopenia in non-cirrhotic chronic liver disease populations. The aim of this study is to investigate if sarcopenia is associated with low testosterone levels in patients with cirrhosis. MATERIAL AND METHODS: This is a retrospective analysis of prospectively collected data of 211 cirrhotic patients undergoing evaluation for liver transplantation...
July 2018: Annals of Hepatology
https://www.readbyqxmd.com/read/29893703/urinary-neutrophil-gelatinase-associated-lipocalin-in-cirrhotic-patients-with-acute-kidney-injury
#8
Hassan S Hamdy, Ahmed El-Ray, Mohamed Salaheldin, Mohammad Lasheen, Mohamed Aboul-Ezz, Ahmed S Abdel-Moaty, Ali Abdel-Rahim
INTRODUCTION AND AIM: It is well known that development of acute kidney injury (AKI) increases mortality in hospitalized cirrhotic patients; therefore many novel markers have been studied for early detection, differential diagnosis and prognosis in cirrhotic patients with AKI. The aim of the current work is to evaluate urinary Neutrophil Gelatinase-Associated Lipocalin (uNGAL) as a diagnostic biomarker for different causes of acute kidney injury in liver cirrhosis and to assess it as a prognostic marker...
July 2018: Annals of Hepatology
https://www.readbyqxmd.com/read/29893702/racial-ethnic-and-age-disparities-in-incidence-and-survival-of-intrahepatic-cholangiocarcinoma-in-the-united-states-1995-2014
#9
Samuel O Antwi, Omar Y Mousa, Tushar Patel
INTRODUCTION AND AIM: Despite reports of increased incidence of intrahepatic cholangiocarcinoma (iCCA) in the United States, the impact of age or influences of race and ethnicity are not clear. Disparities in iCCA outcomes across various population subgroups also are not readily recognized due to the rarity of this cancer. We examined ethnic, race, age, and gender variations in iCCA incidence and survival using data from the Surveillance, Epidemiology, and End Results Program (1995-2014)...
July 2018: Annals of Hepatology
https://www.readbyqxmd.com/read/29893701/frequency-and-characteristics-of-occult-hepatitis-b-infection-among-hepatocellular-carcinoma-patients-in-japan
#10
Jun Muto, Masaya Sugiyama, Ken Shirabe, Motokazu Mukaide, Ikue Kirikae-Muto, Toru Ikegami, Tomoharu Yoshizumi, Yo-Ichi Yamashita, Yoshihiko Maehara, Masashi Mizokami
INTRODUCTION AND AIM: Occult hepatitis B virus (HBV) infection (OBI) represents a state without detectable hepatitis B surface antigen, but positive for HBV DNA. The correlation between OBI and hepatocellular carcinoma (HCC) carcinogenesis is controversial. We studied the frequency and characteristics of OBI among HCC patients and metastatic liver cancer patients. MATERIAL AND METHODS: DNA was obtained from tumor and non-tumor tissues from 75 HCC patients (15 chronic hepatitis B (CHB), 39 chronic hepatitis C (CHC), 21 cryptogenic) and 15 metastatic liver cancer patients who underwent liver resection...
July 2018: Annals of Hepatology
https://www.readbyqxmd.com/read/29893700/correlation-of-apri-index-with-metavir-index-in-children-with-neonatal-cholestasis-without-biliary-atresia
#11
Ira Shah, Nikita Madgum
INTRODUCTION AND AIM: Neonatal cholestasis constitutes for 19 to 33% of all chronic liver disease in India. Cholestasis leads to fibrosis of liver and ultimately cirrhosis. There are various methods of diagnosis of fibrosis of liver like fibroscan, APRI index, FIB-4, fibro index, forns index, heap score, magnetic elastography. Here we are comparing APRI index with METAVIR index in patients with neonatal cholestasis without biliary atresia and determining whether APRI index can be used as a tool to determine fibrosis in these patients...
July 2018: Annals of Hepatology
https://www.readbyqxmd.com/read/29893699/impact-of-diabetes-mellitus-and-insulin-on-nonalcoholic-fatty-liver-disease-in-the-morbidly-obese
#12
Cláudia B M Strey, Luiz A de Carli, Marciane Fantinelli, Sabrina S Gobbato, Guilherme F Bassols, Alexandre Losekann, Gabriela P Coral
INTRODUCTION AND AIM: The prevalence of obesity, type 2 diabetes mellitus and non-alcoholic fatty liver disease are increasing. Type 2 diabetes mellitus may aggravate non-alcoholic fatty liver disease, increasing the risk of developing cirrhosis and hepatocellular carcinoma. This study aims to determine the effect of type 2 diabetes mellitus and insulin therapy on non-alcoholic fatty liver disease in the patients with morbid obesity. MATERIAL AND METHODS: Clinical, anthropometric and laboratory data were analyzed together with intraoperative liver biopsies from morbidly obese patients undergoing bariatric surgery...
July 2018: Annals of Hepatology
https://www.readbyqxmd.com/read/29893698/association-between-serum-hemoglobin-levels-and-non-alcoholic-fatty-liver-disease-in-a-mexican-population
#13
Eva Juárez-Hernández, Norberto C Chávez-Tapia, Diana C Brizuela-Alcántara, Misael Uribe, Martha H Ramos-Ostos, Natalia Nuño-Lámbarri
INTRODUCTION AND AIM: Nonalcoholic fatty liver disease (NAFLD) is closely associated with overweight and obesity, becoming one of the most prevalent hepatic diseases nowadays. Circulating hemoglobin (Hb) concentration is significantly higher in people with NAFLD, compared to healthy patients. While liver biopsy remains the gold standard for NAFLD diagnosis, it is not the best technique due to adverse events that may occur. Therefore it is important to find less invasive and more sensitive markers...
July 2018: Annals of Hepatology
https://www.readbyqxmd.com/read/29893697/extracellular-matrix-proteins-substantiate-il-28b-t-allele-effect-on-histological-outcome-of-chronic-hepatitis-c
#14
Abdelfattah M Attallah, Dalia Omran, Mohamed M Omran, Mohamed A Abdelrazek, Rania Zayed, Riham El Essawey, Sameh Saif, Azza Farid, Mohamed Hassany, Ayman Yosry, Ashraf Omar
INTRODUCTION AND AIM: The correlation between interleukin-28B (IL-28B) polymorphisms and chronic hepatitis C (CHC) progression is debatable. Here, we aimed to evaluate the relation between IL-28B C/T genotypes and the development of cirrhotic liver. Extracellular matrix (ECM) proteins, FibroScan and model for end-stage liver disease (MELD) were used to substantiate the severity of liver disease. MATERIAL AND METHODS: IL-28B rs12979860, liver stiffness and ECM proteins were assessed in 272 CHC patients...
July 2018: Annals of Hepatology
https://www.readbyqxmd.com/read/29893696/new-insights-about-albumin-and-liver-disease
#15
Joana R Carvalho, Mariana Verdelho Machado
Decompensated liver cirrhosis has a dismal prognosis, with an overall survival of 2-4 years, which is worse than for many oncological diseases. Albumin is an important tool in the management of patients with cirrhosis, since it decreases for less than half the risk for post-paracentesis cardiocirculatory dysfunction and mortality associated with spontaneous bacterial infection, as well as, it triplicates the response to terlipressin in patients with hepatorenal syndrome. Recently, research on albumin has been a hot topic, with important new insights such as the characterization of the pleiotropic effects of albumin (which surpass its oncotic properties) and the concept of effective albumin concentration...
July 2018: Annals of Hepatology
https://www.readbyqxmd.com/read/29893695/relationship-of-severity-of-hepatitis-a-with-polymorphisms-in-hepatitis-a-virus-cellular-receptor-1-havcr1-gene
#16
Mercilena Benjamin, Shikha Agnihotry, Anshu Srivastava, Rishi Bolia, S K Yachha, Rakesh Aggarwal
INTRODUCTION AND AIM: HAVCR1 protein is the cellular receptor for hepatitis A virus (HAV). Genetic polymorphism in this gene may alter the outcome of HAV infection. In a previous study, a 6-amino acid insertion (157insMTTTVP) in HAVCR1 gene was associated with more severe disease. We decided to investigate this association further. MATERIAL AND METHODS: We sequenced exon 4 of the HAVCR1 gene in patients with clinical hepatitis A attending our institution, and a group of healthy controls in a disease-endemic setting in India...
July 2018: Annals of Hepatology
https://www.readbyqxmd.com/read/29893694/hepatitis-e-virus-still-an-enigma-in-mexico
#17
Mauricio Realpe-Quintero, Oliver Viera-Segura, Nora A Fierro
Based on high seroprevalence, null surveillance, and lack of diagnostics, Mexico is a high-risk region for hepatitis E Virus (HEV) infection. However, few local news on infection are available. Clinicians and general population are in need of increasing awareness, and preventive measures should be emphasized.
July 2018: Annals of Hepatology
https://www.readbyqxmd.com/read/29894289/occult-hepatitis-b-and-other-unexplored-risk-factors-for-hepatocellular-carcinoma-in-latin-america
#18
Sonia Roman
Occult hepatitis B infection (OBI) is the presence of hepatitis B virus (HBV) DNA in the liver and/or serum (< 200 IU/mL) in HBsAgnegative patients with or without serologic markers of previous viral exposure. The clinical significance of OBI is of concern in posttransfusional hepatitis B infection, hepatitis B reactivation, chronic liver disease and hepatocellular carcinoma (HCC). The diagnosis of OBI relays on the use of highly sensitive and specific laboratory techniques. Herein, comments derived from a study analyzing the frequency and characteristics of OBI in HCC Japanese patients are stated...
June 20, 2018: Annals of Hepatology
https://www.readbyqxmd.com/read/29735803/the-observed-effect-of-gastric-bypass-surgery-on-direct-acting-antiviral-treatment-a-case-report
#19
Elise J Smolders, Sophie B Willemse, Omar El-Sherif, Saye Khoo, David M Burger
Chronic hepatitis C virus (HCV) infection can be cured with treatment using direct-acting antivirals (DAAs). Although these drugs have been widely studied, information about certain special populations is missing. In this case report we describe a treatment-experienced patient with chronic HCV infection genotype 1b, treated with 150 mg/day simeprevir, 400 mg/day sofosbuvir, and 1,000 mg/ day ribavirin for 24 weeks, after a Roux-and-Y gastric bypass. At steady-state a pharmacokinetic curve was recorded of sofosbuvir, GS-331007, and simeprevir...
May 2018: Annals of Hepatology
https://www.readbyqxmd.com/read/29735802/hcbp6-is-involved-in-the-development-of-hepatic-steatosis-induced-by-high-fat-diet-and-ccl4-in-rats
#20
Yong-Ping Zheng, Xian-Yang Zhong, Yu-Shu Huang, Can-Bin Zheng
INTRODUCTION AND AIM: Hepatitis C virus core-binding protein 6 (HCBP6) was previously found to be an hepatitis C virus corebinding protein, its biological function remains unclear. Our research aims to investigate the role of HCBP6 in the development of hepatic steatosis induced by high-fat diet and carbon tetrachloride (CCL4) in rats. MATERIAL AND METHODS: Eighteen Wistar rats were randomly allocated into 3 groups: control group, model group 1, and model group 2...
May 2018: Annals of Hepatology
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