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Annals of Hepatology

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https://www.readbyqxmd.com/read/28612753/do-late-bubbles-correspond-to-early-hepatopulmonary-syndrome
#1
Hilary M DuBrock, Michael J Krowka
No abstract text is available yet for this article.
August 1, 2017: Annals of Hepatology
https://www.readbyqxmd.com/read/28612752/hepatocellular-carcinoma-pay-now-or-pay-more-later
#2
Morris Sherman
No abstract text is available yet for this article.
August 1, 2017: Annals of Hepatology
https://www.readbyqxmd.com/read/28612751/fighting-mortality-in-the-waiting-list-liver-transplantation-in-north-america-europe-and-asia
#3
Daniel Zamora-Valdes, Pilar Leal-Leyte, Peter T W Kim, Giuliano Testa
Liver disease is a major cause of mortality worldwide. Liver transplantation (LT) is the most effective treatment for end stage liver disease. Available resources and social circumstances have led to different ways of implementing LT around the world. The experience with pediatric LT corroborates the hypothesis that a combination of surgical strategies can be beneficial. The goal of this manuscript is to describe the strategies used by LT centers in North America, Europe and Asia and how these strategies can be applied to reduce waitlist mortality and increase access to LT...
August 1, 2017: Annals of Hepatology
https://www.readbyqxmd.com/read/28612750/genetic-and-epigenetic-profile-of-patients-with-alcoholic-liver-disease
#4
Luigi Boccuto, Ludovico Abenavoli
Alcoholic liver disease (ALD) is a definition encompassing a spectrum of disorders ranging from simple steatosis to cirrhosis and hepatocellular carcinoma. Excessive alcohol consumption triggers a series of metabolic reactions that affect the liver by inducing lipogenesis, increasing oxidative stress, and causing abnormal inflammatory responses. The metabolic pathways regulating lipids, reactive oxygen species (ROS), and immune system are closely related and in some cases cross-regulate each other. Therefore, it must be taken into account that major genetic and epigenetic abnormalities affecting enzymes involved in one of such pathways can play a pivotal role in ALD pathogenesis...
August 1, 2017: Annals of Hepatology
https://www.readbyqxmd.com/read/28612749/liver-biopsy-in-chronic-liver-diseases-is-there-a-favorable-benefit-risk-balance
#5
Dominique Larrey, Lucy Meunier, José Ursic-Bedoya
Liver biopsy is still useful in selected clinical situations in which it is the only tool to obtain information necessary for the diagnosis, the prognosis, and the decision for treatment. Main examples are viral hepatitis with confounding co-morbidities, non alcoholic fatty liver disease, and autoimmune liver diseases.
August 1, 2017: Annals of Hepatology
https://www.readbyqxmd.com/read/28611274/meta-analysis-of-randomized-controlled-trials-of-pharmacologic-agents-in-non-alcoholic-steatohepatitis
#6
Adnan Said, Ahmed Akhter
BACKGROUND: Currently, there is no standardized treatment regimen for non-alcoholic steatohepatitis. AIM: We performed a metaanalysis of high quality randomized controlled trials that evaluated treatment response to metformin, thiazolidinediones (TZDs), and vitamin E in adult patients with non-alcoholic steatohepatitis. Outcome measures were improvement in liver histology, biochemical, and anthropometric measures. MATERIAL AND METHODS: Nine trials met inclusion criteria (3 with TZD, 3 with Metformin, 2 with Vitamin E and 1 with both TZD and Vitamin E...
August 1, 2017: Annals of Hepatology
https://www.readbyqxmd.com/read/28611273/racial-disparities-in-hepatitis-c-treatment-eligibility
#7
Omar Sims, David Pollio, Barry Hong, Carol North
BACKGROUND: Hepatitis C (HCV) is more prevalent in African Americans than in any other racial group in the United States. However, African Americans are more likely to be deemed ineligible for HCV treatment than non-African Americans. There has been limited research into the origins of racial disparities in HCV treatment eligibility. AIM: The purpose of this study was to compare medical and non-medical characteristics commonly assessed in clinical practice that could potentially contribute to HCV treatment ineligibility disparities between African American and non-African American patients...
August 1, 2017: Annals of Hepatology
https://www.readbyqxmd.com/read/28611272/a-case-report-of-hepatocellular-carcinoma-5-years-after-hbsag-loss-in-chronic-hepatitis-delta-how-long-surveillance-is-required
#8
Laura Escolà-Vergé, Mar Riveiro-Barciela, Maria Buti
BACKGROUND: Hepatitis delta virus infection occurs as acute co-infection or as superinfection in patients with preexisting chronic hepatitis B. Chronic hepatitis delta leads to more severe disease than chronic hepatitis B, with more rapid progression of fibrosis and increased risk of hepatocelullar carcinoma. CASE REPORT: We report a case of hepatocelullar carcinoma 5 years after spontaneous clearance of Hepatitis B surface antigen in a patient with previous chronic hepatitis delta...
August 1, 2017: Annals of Hepatology
https://www.readbyqxmd.com/read/28611271/expression-of-natural-killer-cell-inhibitory-receptors-is-associated-with-significant-liver-injury-in-chronic-hepatitis-c-in-children
#9
Anna Mania, Mariusz Kaczmarek, Pawel Kemnitz, Magdalena Figlerowicz, Jan Sikora, Wojciech Sluzewski, Jan Zeromski
INTRODUCTION AND AIM: Natural Killer (NK) cells play an important role in innate immune response to viral infections and their high proportion is situated in the liver. The aim of this study was to analyze possible relation between the expression of NK cell receptors and varied intensity of liver lesions in chronic hepatitis C (CHC) in children. MATERIAL AND METHODS: Study included 105 children with CHC - 54 boys and 51 girls, age 13.62 ± 3.48 years. Blood specimens were taken at the day of the liver biopsy...
August 1, 2017: Annals of Hepatology
https://www.readbyqxmd.com/read/28611270/two-cases-of-primary-hepatic-neuroendocrine-tumors-and-a-review-of-the-current-literature
#10
Matthew DeLuzio, Andrea Barbieri, Gary Israel, Sukru Emre
Neuroendocrine tumors comprise approximately 1-2% of all gastrointestinal tumors, and while the liver is the most common site for metastasis of these tumors, primary hepatic neuroendocrine tumors are very rare entities. Since first being reported in 1958, there have been less than 150 cases reported in the literature. Because of the infrequent occurrence of these tumors, the pool of data available for analysis regarding these tumors is small. As such, the medical community must rely on the publication of case report data to further enlarge this data pool, with the hopes of eventually having enough data to draw meaningful, statistically significant conclusions with regard to diagnosis and management of these rare tumors...
August 1, 2017: Annals of Hepatology
https://www.readbyqxmd.com/read/28611269/the-role-of-tips-in-patients-with-refractory-ascites-and-portal-vein-thrombosis
#11
Paulina Chinchilla-López, Nashla Hamdan-Pérez, Jorge Guerrero-Ixtlahuac, Beatriz Barranco-Fragoso, Nahum Méndez-Sánchez
Nowadays the contraindication for Transjugular intrahepatic portosystemic shunt (TIPS) in patients with portal vein thrombosis (PVT) had been modify. The experience and technology have reduce the complications for this procedure. We report a case of refractory ascites and portal vein thrombosis to emphasize the role of TIPS in the treatment for this condition.
August 1, 2017: Annals of Hepatology
https://www.readbyqxmd.com/read/28611268/hepatitis-c-virus-infection-and-risk-of-venous-thromboembolism-a-systematic-review-and-meta-analysis
#12
Karn Wijarnpreecha, Charat Thongprayoon, Panadeekarn Panjawatanan, Patompong Ungprasert
BACKGROUND/OBJECTIVES: Hepatitis C virus (HCV) infection is one of the leading causes of cirrhosis. As a result of chronic inflammatory response to the virus, HCV-infected patients may be at a higher risk of venous thromboembolism (VTE). However, the data on this association is unclear. This systematic review and meta-analysis was conducted with the aims to summarize all available evidence. MATERIAL AND METHODS: A literature search was performed using MEDLINE and EMBASE from inception to April 2016...
August 1, 2017: Annals of Hepatology
https://www.readbyqxmd.com/read/28611267/occult-hepatitis-c-infection-among-hemodialysis-patients-a-prevalence-study
#13
Reza Naghdi, Mitra Ranjbar, Farah Bokharaei-Salim, Hossein Keyvani, Shokoufeh Savaj, Shahrzad Ossareh, Amir Shirali, Amir Mohammad-Alizadeh
INTRODUCTION AND AIM: Occult hepatitis C infection (OHCI) is the presence of HCV-RNA in the liver or peripheral blood mononuclear cells (PBMC) accompanying with negative serologic results. The aim of this study was to evaluate the prevalence of OHCI among Iranian chronic hemodialysis (HD) patients. MATERIAL AND METHODS: In this cross sectional study 200 chronic HD patients with negative HCV antibody enrolled the study. Blood sample of patients were obtained, followed by Polymerase Chain reaction (PCR) testing for detection of HCV RNA...
August 1, 2017: Annals of Hepatology
https://www.readbyqxmd.com/read/28611266/retinoid-x-receptor-%C3%AE-dependent-hbv-minichromosome-remodeling-and-viral-replication
#14
Yan Zhang, Song He, Jin-Jun Guo, Hong Peng, Jia-Hao Fan, Qing-Ling Li
BACKGROUND AND AIM: The HBV covalently closed circular DNA (cccDNA) is organized into a minichromosome in the nuclei of infected hepatocytes through interactions with histone and nonhistone proteins. Retinoid X receptor α (RXRα), a liver-enriched nuclear receptor, participates in regulation of HBV replication and transcription through modulation of HBV enhancer 1 and core promoter activity. MATERIAL AND METHODS: This study investigated RXRα involvement in HBV cccDNA epigenetic modifications...
August 1, 2017: Annals of Hepatology
https://www.readbyqxmd.com/read/28611265/hepatoprotective-effect-of-curcumin-on-hepatocellular-carcinoma-through-autophagic-and-apoptic-pathways
#15
Ahmed Elmansi, Amro El-Karef, Mamdouh Shishtawy, Laila Eissa
BACKGROUND AND RATIONALE: Microtubule-associated protein light chain 3-II (LC3-II), and Sequestosome-1 (SQSTM1) are proteins that can be used as markers for autophagic pathway. Bcl-2 protein is reported to be inversely correlated with apoptosis. We aimed to investigate the effects of curcumin on liver inflammation and fibrosis up to the first dysplastic stage of Hepatocellular carcinoma (HCC) induced by Thioacetamide (TAA) in rats and to clarify the effects of curcumin on LC3-II, SQSTM1, and Bcl-2...
August 1, 2017: Annals of Hepatology
https://www.readbyqxmd.com/read/28611264/symptoms-of-daytime-sleepiness-and-sleep-apnea-in-liver-cirrhosis-patients
#16
Abdullah Enezi, Fares Al-Jahdali, Anwar Ahmed, Nahid Shirbini, Abdullah Harbi, Baharoon Salim, Yosra Ali, Aljumah Abdulrahman, Mohd Khan, Abdullah Khaleid, Al-Jahdali Hamdan
Background/propose. Sleep disturbance and excessive daytime sleepiness (EDS) have been reported in patients with hepatic cirrhosis with no hepatic encephalopathy (HE). The objective of this study was to evaluate daytime sleepiness and risk of obstructive sleep apnea (OSA) among liver cirrhosis patients. MATERIAL AND METHODS: A cross-sectional study was conducted at King Abdulaziz Medical City (KAMC)-Riyadh over a period of six months, using a structured questionnaire that investigated: 1) Sleep patterns and daytime sleepiness using the Epworth Sleeping Scale (ESS), and 2) The risk for sleep apnea using the Berlin Questionnaire (BQ)...
August 1, 2017: Annals of Hepatology
https://www.readbyqxmd.com/read/28611263/hepatic-echinococcosis-with-thoracic-involvement-clinical-characteristics-of-a-prospective-series-of-cases
#17
Carlos Manterola, Tamara Otzen
INTRODUCTION: Thoracic involvement (TIHE) is one of the evolutionary complications of hepatic echinococcosis (HE). AIM: The aim of this study was to describe the clinical characteristics and postoperative morbidity (POM) of a series of patients with TIHE treated surgically. MATERIAL AND METHODS: Series of cases of patients treated for TIHE between 2000 and 2014 in the Hospital Regional and Clínica Mayor in Temuco, Chile, with a minimum 12-month follow-up...
August 1, 2017: Annals of Hepatology
https://www.readbyqxmd.com/read/28611262/relative-adrenal-insufficiency-is-associated-with-the-clinical-outcome-in-patients-with-stable-decompensated-cirrhosis
#18
Evangelos Cholongitas, Ioannis Goulis, Eirini Pagkalidou, Anna Haidich, Apostolos Karagiannis, Theodora Nakouti, Chrysoula Pipili, Theodora Oikonomou, Spyros Gerou, Evangelos Akriviadis
BACKGROUND: The clinical impact of relative adrenal insufficiency (AI) on patients with stable decompensated cirrhosis (DeCi) has not been yet elucidated. AIM: Explore the association between AI and outcome [death or liver transplantation (LT)] in patients with DeCi. MATERIAL AND METHODS: Patients with DeCi presenting no active complication have been included. Clinical and laboratory data, including serum levels of corticosteroid-binding globulin (CBG), interleukin (IL)-1b, IL-6 and tumor necrosis factor (TNFα) were recorded in each participant...
August 1, 2017: Annals of Hepatology
https://www.readbyqxmd.com/read/28611261/non-neoplastic-portal-vein-thrombosis-in-hcv-cirrhosis-patients-is-it-an-immuno-inflammatory-disorder
#19
Mona Abu El-Makarem, Atef El-Akad, Moustafa Elian, Tahra Sherif, Ragaa El-Shaheed, Aliaa Abd El Fatah, Douaa Sayed, Rania Bakry, Aisha Mahmoud
BACKGROUND AND AIMS: Portal vein thrombosis (PVT) is a critical complication in cirrhotic patients. We explored the role of the activated factor VII-antithrombin (FVIIa-AT) complex and enhanced monocytic tissue factor (TF) expression in the development and prediction of non-neoplastic PVT in cirrhotic patients. MATERIAL AND METHODS: A total of 30 HCV-cirrhosis patients were included in our study. They were compared to 35 cirrhotic patients without PVT, 15 non-cirrhotic patients with PVT, and 15 healthy controls...
August 1, 2017: Annals of Hepatology
https://www.readbyqxmd.com/read/28611260/sensitivity-and-specificity-of-biochemical-tests-for-diagnosis-of-intrahepatic-cholestasis-of-pregnancy
#20
Jurate Kondrackiene, Rimantas Zalinkevicius, Jolanta Sumskiene, Vladas Gintautas, Limas Kupcinskas
BACKGROUND AND AIM: Intrahepatic cholestasis of pregnancy (ICP) is linked with increased risk of fetal complications. An accurate diagnostic test is needed to diagnose this disorder on time. We aimed to assess sensitivity and specificity of laboratory tests used for diagnosis of intrahepatic cholestasis of pregnancy and determine more reliable cut-off values of transaminases. MATERIAL AND METHODS: Sixty one symptomatic patients with ICP and 29 healthy pregnant women were included in the retrospective analysis...
August 1, 2017: Annals of Hepatology
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