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Annals of Hepatology

Nahum Méndez-Sánchez
No abstract text is available yet for this article.
March 1, 2017: Annals of Hepatology
K R Chacko, A W Wolkoff
No abstract text is available yet for this article.
March 1, 2017: Annals of Hepatology
Zhong Chen, Zongji Shen, Lingqing Hu, Mudan Lu, Yizhong Feng
Intrahepatic cholestasis of pregnancy (ICP) is a severe liver disease uniquely occurring during pregnancy. In this study we aimed to identify novel biomarker for the diagnosis of ICP in Chinese population. 50 healthy pregnant women, 50 mild ICP patients and 48 severe ICP patients were enrolled for this study. Liver function tests, including serum total bilirubin, direct bilirubin, alanine transaminase, aspartate aminotransferase and cholyglycine, were performed in all participants. After an overnight fast serum levels of total bile acids (TBA), matrix metalloproteinase (MMP)-2 and MMP-9 were measured, and their correlation with liver function tests were analyzed...
March 1, 2017: Annals of Hepatology
Wendy Bautista, Jeremy Lipschitz, Andrew McKay, Gerald Y Minuk
INTRODUCTION AND AIM: The inability to distinguish cancer (CSCs) from normal stem cells (NSCs) has hindered attempts to identify safer, more effective therapies for hepatocellular carcinoma (HCC). The aim of this study was to document and compare cell membrane potential differences (PDs) of CSCs and NSCs derived from human HCC and healthy livers respectively and determine whether altered GABAergic innervation could explain the differences. MATERIAL AND METHODS: Epithelial cell adhesion molecule (EpCAM) positive stem cells were isolated from human liver tissues by magnetic bead separations...
March 1, 2017: Annals of Hepatology
Amy Shriver, Sean Rudnick, Nicolas Intagliata, Amanda Wang, Stephen H Caldwell, Patrick Northup
INTRODUCTION: The aim of this study is to investigate large volume therapeutic paracentesis using either a z-tract or axial (coxial) technique in a randomized controlled trial. MATERIALS AND METHODS: In this randomized, single blind study, patients with cirrhosis undergoing outpatient therapeutic paracentesis were randomized to the z-tract or the modified angular (coaxial) needle insertion technique. Subject and procedure characteristics were compared between the groups with ascites leakage as quantified by need for dressing changes with standardized sized gauze pads as a primary endpoint and subject procedural discomfort, operator preference, and procedure complications as secondary endpoints...
March 2017: Annals of Hepatology
Sara Campos, Nuno Silva, Armando Carvalho
BACKGROUND: In clinical practice, it is assumed that a severe rise in transaminases is caused by ischemic, viral or toxic hepatitis. Nevertheless, cases of biliary obstruction have increasingly been associated with significant hypertransaminemia. With this study, we sought to determine the true etiology of marked rise in transaminases levels, in the context of an emergency department. MATERIAL AND METHODS: We retrospectively identified all patients admitted to the emergency unit at Centro Hospitalar e Universitário de Coimbra between 1st January 2010 and 31st December 2010, displaying an increase of at least one of the transaminases by more than 15 times...
March 1, 2017: Annals of Hepatology
Fernanda Branco, Regiane S M Alencar, Fernanda Volt, Giovana Sartori, Andressa Dode, Luciana Kikuchi, Claudia M Tani, Aline L Chagas, Tulio Pfiffer, Paulo Hoff, Flair J Carrilho, Angelo A Mattos
BACKGROUND AND AIMS: The presence of dermatologic reaction as an adverse event to sorafenib treatment in patients with unresectable hepatocellular carcinoma has been indicated as a prognostic factor for survival in a recent prospective analysis. To date, this is the only clinical predictor of treatment response, which can be evaluated earlier in the treatment and, therefore, contribute to a better and more individualized patient management. MATERIAL AND METHODS: This retrospective study included 127 patients treated with sorafenib under real-life practice conditions in two hepatology reference centers in Brazil...
March 1, 2017: Annals of Hepatology
Hugo Perazzo, Antonio G Pacheco, Raquel De Boni, Paula M Luz, Juliana Fittipaldi, Sandra W Cardoso, Beatriz Grinsztejn, Valdiléa G Veloso
No abstract text is available yet for this article.
March 1, 2017: Annals of Hepatology
Joy Varghese, Chandan Kedarisetty, Jayanthi Venkataraman, Vijaya Srinivasan, Thiruchunapalli Deepashree, Mangerira Uthappa, Kaliamurthy Ilankumaran, Sanjay Govil, Mettu Reddy, Mohamed Rela
Background & Aim. Transarterial chemoembolization (TACE) or sorafenib is recommended for hepatocellular carcinoma BCLC stages B and C respectively. We studied the role of combination of TACE and sorafenib in BCLC stages B/C. MATERIAL AND METHODS: We undertook an observational study on a cohort of cirrhotics with HCC from August 2010 through October 2014. Patients in BCLC stages B/C who had received TACE and/or sorafenib were included. mRECIST criteria were used to assess tumor response...
March 1, 2017: Annals of Hepatology
Sandra R Almeida-Carvalho, Maria L Gomes-Ferraz, Carla A Loureiro-Matos, Antônio E Benedito-Silva, Roberto J Carvalho-Filho, Rogério Renato-Perez, Adriano Miziara-Gonzalez, Alcides A Salzedas-Netto, Denis Szejnfeld, Giuseppe D'Ippolito, Valéria Pereira-Lanzoni, Ivonete Souza-Silva
BACKGROUND: Hepatocellular carcinoma (HCC) is the most common malignancy that develops in cirrhotic livers. Its clinical and epidemiological characteristics and mortality rates vary according to geographical region. The objective of this study was to evaluate the clinical profile, epidemiological characteristics, laboratory parameters, treatment and survival of patients with HCC. MATERIAL AND METHODS: Patients with HCC seen between 2000 and 2012 were studied. The Kaplan-Meier method was used for survival analysis according to variables in question...
March 1, 2017: Annals of Hepatology
Stephen Ip, Trana Hussaini, Aliya Daulat, Nilufar Partovi, Siegfried R Erb, Eric M Yoshida, Vladimir Marquez
BACKGROUND: Chronic renal failure (CRF) is a significant cause of morbidity and mortality in post-liver transplantation (LT) recipients. The risk factors associated with the development of renal dysfunction are not clearly elucidated. OBJECTIVES: To examine the risk factors in the development of CRF in these patients. MATERIAL AND METHODS: Retrospective case-cohort of liver transplant patients without baseline kidney dysfunction who developed chronic renal failure during their follow-up...
March 1, 2017: Annals of Hepatology
Constantine J Karvellas, Filipe S Cardoso, Marco Senzolo, Malcolm Wells, Mansour G Alghanem, Fayaz Handou, Lukasz Kwapisz, Norman M Kneteman, Paul J Marotta, Bandar Al-Judaibi
INTRODUCTION: To identify the impact of portal vein thrombosis (PVT) and associated medical and surgical factors on outcomes post liver transplant (LT). MATERIAL AND METHODS: Two analyses were performed. Analysis One: cohort study of 505 consecutive patients who underwent LT (Alberta) between 01/2002-12/2012. PVT was identified in 61 (14%) patients. Analysis Two: cohort study of 144 consecutive PVT patients from two sites (Alberta and London) during the same period...
March 1, 2017: Annals of Hepatology
Jonathan G Stine, Javelle A Wynter, Blake Niccum, Virginia Kelly, Stephen H Caldwell, Neeral L Shah
No abstract text is available yet for this article.
March 1, 2017: Annals of Hepatology
Karina Gonzalez-Aldaco, João R Rebello Pinho, Arturo Panduro, Erika Martinez-Lopez, Ketti Gleyzer, Nora Fierro, Sonia Roman
BACKGROUND: The prevalence of two functional polymorphisms (rs1127354 and rs7270101) of the inosine triphosphatase (ITPA) gene associated with ribavirin-induced hemolytic anemia (RIHA) during antiviral therapy for hepatitis C virus (HCV) infection varies by ethnicity. In Mexico, the distribution of these polymorphisms among Native Amerindians (NA) and admixed population (Mestizos) is unknown. This study aimed to determine the prevalence of the ITPA polymorphisms among healthy NA and Mestizos, as well as in HCV patients from West Mexico...
March 1, 2017: Annals of Hepatology
Maria Guarino, Marco Picardi, Anna Vitello, Novella Pugliese, Matilde Rea, Valentina Cossiga, Fabrizio Pane, Nicola Caporaso, Filomena Morisco
HBV and HCV reactivation has been widely reported in patients undergoing immunosuppressive therapy for oncohaematological diseases. We aimed to evaluate the HBV and HCV reactivation events in patients with non-Hodgkin lymphoma (NHL) or Hodgkin lymphoma (HL) underwent cytotoxic chemotherapy containing or not rituximab. This is a retrospective observational study, including all patients with NHL and HL attending an Italian tertiary referral hospital, the University of Naples "Federico II". A total of 322 patients were enrolled...
March 1, 2017: Annals of Hepatology
Ramesh Saeedi, Ali Mojebi-Mogharar, Supna K Sandhu, Joshua A Dubland, Jo-Ann Ford, Masoud Yousefi, Morris Pudek, Daniel T Holmes, Siegfried R Erb, Wing Peter Kwan, David L Kendler, Eric M Yoshida
BACKGROUND: Patients with chronic hepatitis B virus (HBV) are often treated with nucleoside/nucleotide antiviral agents and metabolic bone toxicity is a possible concern. OBJECTIVE: To determine the relationships between fibroblast growth factor 23 (FGF23), a phosphaturic hormone, bone mineral density (BMD), and bone biochemical abnormalities in these patients. MATERIAL AND METHODS: This is a cross-sectional observational study comparing HBV-infected subjects treated for at least one year with tenofovir (TDF), lamuvidine (LVD), entacavir (ETV), or not treated (CON)...
March 1, 2017: Annals of Hepatology
María L Morales, Carmen Sendra, Manuel Romero-Gomez
Hepatitis B virus infection seems to protect against steatosis and insulin resistance decreasing NAFLD. Metabolic syndrome has been associated with increased risk of disease progression to cirrhosis and liver cancer in hepatitis B. HBsAg seroclearance increased over time and it could be a confounding factor when analysing NAFLD and hepatitis B prevalence.
March 1, 2017: Annals of Hepatology
Mohammad S Rezaee-Zavareh, Khashayar Hesamizadeh, Bita Behnava, Seyed M Alavian, Mohammad Gholami-Fesharaki, Heidar Sharafi
No abstract text is available yet for this article.
March 1, 2017: Annals of Hepatology
Isaac Ruiz, Jean-Michel Pawlotsky
No abstract text is available yet for this article.
March 1, 2017: Annals of Hepatology
Stephen Caldwell, Carolin Lackner
Interpretation of liver biopsy in NAFLD can be challenging to distinguish histological NASH from non-NASH fatty liver - a broad dichotomy which carries significant prognostic and therapeutic implications and underlies the utility of many non-invasive tests. There is usually a reasonable degree of inter-observer agreement for some key parameters like steatosis, inflammation and fibrosis staging. However, the assessment of cellular ballooning can be a stumbling block even for experienced observers. Below, we recount some aspects of the history of histological definitions in NASH and propose specific methods to more objectively identify cellular ballooning in routine biopsy assessments...
March 1, 2017: Annals of Hepatology
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