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Expert Review of Vaccines

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https://www.readbyqxmd.com/read/28116910/current-developments-and-prospects-on-human-metapneumovirus-vaccines
#1
Verónica Araceli Márquez-Escobar
Human metapneumovirus (hMPV) has become one of the major pathogens causing acute respiratory infections (ARI) mainly affecting young children, immunocompromised patients, and the elderly. Currently there are no licensed vaccines against this virus. Areas covered: Since the discovery of hMPV in 2001, many groups have focused on developing vaccines against this pathogen. This review presents the outcomes and perspectives derived from preclinical studies performed in cell cultures and animals as well as the only candidate that has reached evaluation in a clinical trial...
January 27, 2017: Expert Review of Vaccines
https://www.readbyqxmd.com/read/28043178/towards-clinical-development-of-a-pfs48-45-based-transmission-blocking-malaria-vaccine
#2
Michael Theisen, Matthijs M Jore, Robert Sauerwein
Malaria is a devastating vector-borne disease caused by the Plasmodium parasite, resulting in almost 0.5 million casualties per year. The parasite has a complex life-cycle that includes asexual replication in human red blood cells, causing symptomatic malaria, and sexual stages which are essential for the transmission to the mosquito vector. A vaccine targeting the sexual stages of the parasite and thus blocking transmission will be instrumental for the eradication of malaria. One of the leading transmission blocking vaccine candidates is the sexual stage antigen Pfs48/45...
January 3, 2017: Expert Review of Vaccines
https://www.readbyqxmd.com/read/28010152/consider-stopping-dengvaxia-administration-without-immunological-screening
#3
Maíra Aguiar, Scott B Halstead, Nico Stollenwerk
No abstract text is available yet for this article.
December 28, 2016: Expert Review of Vaccines
https://www.readbyqxmd.com/read/27996332/dtap5-ipv-hib-hepb-a-hexavalent-vaccine-for-infants-and-toddlers
#4
Andrew W Lee, Emilia Jordanov, Florence Boisnard, Gary S Marshall
Combination vaccines reduce the 'shot burden' and simplify the childhood immunization schedule. Only 5-valent DTaP-based vaccines are licensed in the U.S. Areas covered: A new combination vaccine - DTaP5-IPV-Hib-HepB - is described, which induces antibody responses in infants (given in different schedules, including a 2, 4, and 6-month schedule) that are similar to the respective component vaccines. The vaccine appears to be safe and would be expected to protect against six diseases: diphtheria, tetanus, pertussis, hepatitis B, H influenzae type b, and polio...
December 20, 2016: Expert Review of Vaccines
https://www.readbyqxmd.com/read/27918218/vaccine-against-toxic-shock-syndrome-in-a-first-in-man-clinical-trial
#5
Andreas Roetzer, Bernd Jilma, Martha M Eibl
No abstract text is available yet for this article.
December 15, 2016: Expert Review of Vaccines
https://www.readbyqxmd.com/read/27882801/rapid-assessment-of-the-reactogenicity-of-a-2016-2017-seasonal-influenza-vaccine-results-from-a-feasibility-study
#6
Anke L Stuurman, Thomas Verstraeten, Antoon De Schryver
BACKGROUND: ​​The European Medicines Agency (EMA) calls for a strategy for enhanced safety surveillance of seasonal influenza vaccines. OBJECTIVE: We assessed the feasibility of collecting reactogenicity data within one month of the start of the vaccination campaign in Belgium. METHODS: One hundred subjects aged 18 to 65 years who had received inactivated seasonal influenza vaccine in occupational setting were enrolled. For 7 days after vaccination, subjects received a daily SMS with a link to a web-based questionnaire where reactogenicity events and their severity were solicited...
December 1, 2016: Expert Review of Vaccines
https://www.readbyqxmd.com/read/28165831/paxvax-cvd-103-hgr-single-dose-live-oral-cholera-vaccine
#7
Myron M Levine, Wilbur H Chen, James B Kaper, Michael Lock, Lisa Danzig, Marc Gurwith
Cholera remains a problem in developing countries and a risk for travelers. Hypochlorhydria, blood group O, cardiac and renal disease increase the risk of developing cholera gravis. Oral vaccines containing inactivated Vibrio cholerae and requiring two doses are available in some countries. No cholera vaccine had been available for U.S. travelers for decades until 2016 when CVD 103-HgR (VAXCHORA™), an oral live attenuated vaccine, was licensed by the U.S. FDA. Areas covered: Enduring protection following wild-type cholera provided the rationale to develop a single-dose live oral vaccine...
March 2017: Expert Review of Vaccines
https://www.readbyqxmd.com/read/28010142/outer-membrane-vesicles-an-attractive-candidate-for-pertussis-vaccines
#8
Daniela F Hozbor
No abstract text is available yet for this article.
March 2017: Expert Review of Vaccines
https://www.readbyqxmd.com/read/27809689/two-decades-of-pharmacovigilance-and-clinical-experience-with-highly-purified-rabies-immunoglobulin-f-ab-2-fragments
#9
Elisa Reveneau, Pascale Cottin, Anvar Rasuli
Rabies is a worldwide zoonotic viral disease with no specific treatment once symptoms occur; manifest disease is almost always fatal. WHO recommendations for exposed individuals include immediate attention to the wound and use of rabies immunoglobulin and/or vaccine for post-exposure prophylaxis (PEP). Here, we provide an overview of the clinical experience with a highly purified preparation of F(ab')2 fragments from equine rabies immunoglobulin (F(ab')2 pERIG; Favirab(TM)) in rabies PEP. Areas covered: Our review comprises a retrospective analysis of adverse event reports in the Sanofi Pasteur global pharmacovigilance database for F(ab')2 pERIG, including adverse event reports from eight Sanofi Pasteur-sponsored clinical trials and post-market surveillance data collected between 1995 and 2014...
March 2017: Expert Review of Vaccines
https://www.readbyqxmd.com/read/27805467/improving-immunization-approaches-to-cholera
#10
Amit Saha, Alexander Rosewell, Andrew Hayen, C Raina MacIntyre, Firdausi Qadri
Cholera's impact is greatest in resource-limited countries. In the last decade several large epidemics have led to a global push to improve and implement the tools for cholera prevention and control. Areas covered: PubMed, Google Scholar and the WHO website were searched to review the literature and summarize the current status of cholera vaccines to make recommendations on improving immunization approaches to cholera. Oral cholera vaccines (OCVs) have demonstrated their effectiveness in endemic, outbreak response and emergency settings, highlighting their potential for wider adoption...
March 2017: Expert Review of Vaccines
https://www.readbyqxmd.com/read/27797598/the-unrecognized-burden-of-typhoid-fever
#11
Stephen K Obaro, Pui-Ying Iroh Tam, Eric Daniel Mintz
Typhoid fever (TF), caused by Salmonella enterica serovar Typhi, is the most common cause of enteric fever, responsible for an estimated 129,000 deaths and more than 11 million cases annually. Although several reviews have provided global and regional TF disease burden estimates, major gaps in our understanding of TF epidemiology remain. Areas covered: We provide an overview of the gaps in current estimates of TF disease burden and offer suggestions for addressing them, so that affected communities can receive the full potential of disease prevention offered by vaccination and water, sanitation, and hygiene interventions...
March 2017: Expert Review of Vaccines
https://www.readbyqxmd.com/read/27786560/varicella-prevention-in-costa-rica-impact-of-a-one-dose-schedule-universal-vaccination
#12
María L Avila-Aguero, Rolando Ulloa-Gutierrez, Kattia Camacho-Badilla, Alejandra Soriano-Fallas, Roberto Arroba-Tijerino, Ana Morice-Trejos
To describe the impact following a 1-dose Varicella vaccination schedule introduced in Costa Rica in September 2007. Areas covered: This is a retrospective review using epidemiologic surveillance national databases of varicella cases and hospitalizations, period 2000-2015. We analyzed age-related varicella incidence cases and hospitalization trends before and after the vaccine introduction. Expert commentary: Varicella vaccine coverage among children 16 months age increased from 76% in 2008 to 95% in 2015...
March 2017: Expert Review of Vaccines
https://www.readbyqxmd.com/read/27690701/calcium-phosphate-a-substitute-for-aluminum-adjuvants
#13
Jean-Daniel Masson, Michel Thibaudon, Laurent Bélec, Guillemette Crépeaux
Calcium phosphate was used as an adjuvant in France in diphtheria, tetanus, pertussis and poliomyelitis vaccines. It was later completely substituted by alum salts in the late 80's, but it still remains as an approved adjuvant for the World Health Organization for human vaccination. Area covered: Thus, calcium phosphate is now considered as one of the substances that could replace alum salts in vaccines. The aim of this paper is to draw a review of existing data on calcium phosphate as an adjuvant in order to bring out the strengths and weaknesses for its use on a large scale...
March 2017: Expert Review of Vaccines
https://www.readbyqxmd.com/read/27690686/vaccines-for-piscirickettsiosis-salmonid-rickettsial-septicaemia-srs-the-chile-perspective
#14
Kevin Maisey, Ruth Montero, Myron Christodoulides
Piscirickettsia salmonis (P. salmonis) is the aetiological bacterium of the contagious disease piscirickettsiosis or salmonid rickettsial septicaemia (SRS) and causes significant economic losses to aquaculture production in Chile. Current strategies to control infection are i) indiscriminate antibiotic use and ii) vaccination with predominantly P. salmonis bacterin vaccines that do not provide acceptable levels of protection against piscirickettsiosis. Areas covered: This review covers the basic biology of P...
March 2017: Expert Review of Vaccines
https://www.readbyqxmd.com/read/27606709/development-of-replication-deficient-adenovirus-malaria-vaccines
#15
Michael R Hollingdale, Martha Sedegah, Keith Limbach
Malaria remains a major threat to endemic populations and travelers, including military personnel to these areas. A malaria vaccine is feasible, as radiation attenuated sporozoites induce nearly 100% efficacy. Areas covered: This review covers current malaria clinical trials using adenoviruses and pre-clinical research. Heterologous prime-boost regimens, including replication-deficient human adenovirus 5 (HuAd5) carrying malaria antigens, are efficacious. However, efficacy appears to be adversely affected by pre-existing anti-HuAd5 antibodies...
March 2017: Expert Review of Vaccines
https://www.readbyqxmd.com/read/27801602/a-potent-adjuvant-effect-of-a-cd1d-binding-nkt-cell-ligand-in-human-immune-system-mice
#16
Xiangming Li, Jing Huang, Izumi Kaneko, Min Zhang, Shiroh Iwanaga, Masao Yuda, Moriya Tsuji
OBJECTIVES: A CD1d-binding invariant natural killer T (iNKT)-cell stimulatory glycolipid, namely 7DW8-5, is shown to enhance the efficacy of radiation-attenuated sporozoites (RAS)-based malaria vaccine in mice. In the current study, we aim to determine whether 7DW8-5 can display a potent adjuvant effect in human immune system (HIS) mice. METHODS: HIS-A2/hCD1d mice, which possess both functional human iNKT cells and CD8+ T cells, were generated by the transduction of NSG mice with adeno-associated virus serotype 9 expressing genes that encode human CD1d molecules and HLA-A*0201, followed by the engraftment of human hematopoietic stem cells...
January 2017: Expert Review of Vaccines
https://www.readbyqxmd.com/read/27744721/the-risks-of-using-allogeneic-cell-lines-for-vaccine-production-the-example-of-bovine-neonatal-pancytopenia
#17
Lindert Benedictus, Charlotte R Bell
Bovine neonatal pancytopenia (BNP) is a hemorrhagic disease that emerged in calves across Europe in 2007. Its occurrence is attributed to immunization of the calf's mother with a vaccine produced using an allogeneic cell line. Vaccine-induced alloantibodies specific for major-histocompatibility class I antigens are transferred from the mother to the calf via colostrum, leading to profound depletion of peripheral blood and bone marrow cells that is often fatal. Areas covered: Pubmed and Web of Science were used to search for literature relevant to BNP and the use of allogeneic vaccine cell lines...
January 2017: Expert Review of Vaccines
https://www.readbyqxmd.com/read/27539516/dynamic-modelling-approaches-for-the-analysis-of-the-cost-effectiveness-of-seasonal-influenza-control
#18
B M Van Maanen, P T de Boer, F C K Dolk, A W Friedrich, J C Wilschut, R Pitman, M J Postma
No abstract text is available yet for this article.
January 2017: Expert Review of Vaccines
https://www.readbyqxmd.com/read/27500911/advances-and-challenges-dendritic-cell-vaccination-strategies-for-glioblastoma
#19
Teilo H Schaller, John H Sampson
Glioblastoma is the most common primary brain tumor in adults and prognosis remains poor with a median survival of approximately 15-17 months. This review provides an overview of recent advances in the field of glioblastoma immunotherapy. Areas covered: Recent advances in dendritic cell vaccination immunotherapy are showing encouraging results in clinical trials and promise to extend patient survival. In this report we discuss current scientific knowledge regarding dendritic cell (DC) vaccines, including approaches to differentiating, priming, and injecting dendritic cells to achieve maximal anti-tumor efficacy in glioblastoma...
January 2017: Expert Review of Vaccines
https://www.readbyqxmd.com/read/27448771/adjuvant-system-as01-helping-to-overcome-the-challenges-of-modern-vaccines
#20
Arnaud M Didierlaurent, Béatrice Laupèze, Alberta Di Pasquale, Nadia Hergli, Catherine Collignon, Nathalie Garçon
Adjuvants are used to improve vaccine immunogenicity and efficacy by enhancing antigen presentation to antigen-specific immune cells with the aim to confer long-term protection against targeted pathogens. Adjuvants have been used in vaccines for more than 90 years. Combinations of immunostimulatory molecules, such as in the Adjuvant System AS01, have opened the way to the development of new or improved vaccines. Areas covered: AS01 is a liposome-based vaccine adjuvant system containing two immunostimulants: 3-O-desacyl-4'-monophosphoryl lipid A (MPL) and the saponin QS-21...
January 2017: Expert Review of Vaccines
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