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Journals Cancer Research and Treatment ...

Cancer Research and Treatment : Official Journal of Korean Cancer Association

https://read.qxmd.com/read/38228081/feasibility-of-circulating-tumor-dna-analysis-in-patients-with-follicular-lymphoma
#21
JOURNAL ARTICLE
Sang Eun Yoon, Seung-Ho Shin, Dae Keun Nam, Junhun Cho, Won Seog Kim, Seok Jin Kim
PURPOSE: The feasibility of sequencing circulating tumor DNA (ctDNA) in plasma as a biomarker to predict early relapse or poor prognosis in patients with follicular lymphoma (FL) receiving systemic immunochemotherapy is not clear. MATERIALS AND METHODS: We sequenced DNA from cell-free plasma that was serially obtained from newly diagnosed FL patients undergoing systemic immunochemotherapy. The mutation profiles of ctDNA at the time of diagnosis and at response evaluation and relapse and/or progression were compared with clinical course and treatment outcomes...
January 16, 2024: Cancer Research and Treatment: Official Journal of Korean Cancer Association
https://read.qxmd.com/read/38228080/adjuvant-chemotherapy-for-upper-tract-urothelial-carcinoma-a-real-world-retrospective-study
#22
JOURNAL ARTICLE
Junho Lee, Sung Hee Lim, Jae Hoon Chung, Wan Song, Hyun Hwan Sung, Byong Chang Jeong, Se Hoon Park
PURPOSE: The aim of this retrospective study was to evaluate the efficacy of adjuvant cisplatin-based chemotherapy in patients with locally-advanced upper tract urothelial carcinoma (UTUC), administered following radical nephroureterectomy. MATERIALS AND METHODS: Patients with UTUC, arising from renal pelvis or ureter, staged pT3/T4 or N+ were treated with adjuvant chemotherapy following surgery. The chemotherapy consisted of gemcitabine 1,000 mg/m2 on days 1 and 8, cisplatin 70 mg/m2 on day 1...
January 16, 2024: Cancer Research and Treatment: Official Journal of Korean Cancer Association
https://read.qxmd.com/read/38228083/predicted-cervical-cancer-prevention-impact-of-national-hpv-vaccination-program-on-young-women-in-south-korea
#23
JOURNAL ARTICLE
Kyeongmin Kwak, Seung-Sik Hwang
PURPOSE: This study aimed to evaluate the effectiveness of the National HPV Vaccination Program of South Korea among its entire female population, particularly among younger age groups. MATERIALS AND METHODS: We first predicted the incidence of cervical cancer over the next 20 years (2021-2040) using the Nordpred package based on Møller's age-period-cohort model under several scenarios for the National HPV Vaccination Program. We calculated the potential impact fractions (PIFs) and proportional differences under the current national vaccination programs, and alternative scenarios using the no-vaccination assumption as a reference...
January 15, 2024: Cancer Research and Treatment: Official Journal of Korean Cancer Association
https://read.qxmd.com/read/38228084/bridging-the-gap-between-trial-adverse-events-and-real-world-data
#24
JOURNAL ARTICLE
Sang Hyuk Kim, Hyun Lee, Dong Won Park
No abstract text is available yet for this article.
January 10, 2024: Cancer Research and Treatment: Official Journal of Korean Cancer Association
https://read.qxmd.com/read/38186238/analytical-and-clinical-validation-of-a-highly-sensitive-ngs-based-ctdna-assay-with-real-world-concordance-in-nsclc
#25
JOURNAL ARTICLE
Hanbaek Yi, Jeonghwan Youk, Yoojoo Lim, Hanseong Roh, Dongsoo Roh, Dongsoo Kyung, Hwang-Phill Kim, Duhee Bang, Bhumsuk Keam, Tae-Min Kim, Miso Kim, Dong-Wan Kim, Tae-You Kim
PURPOSE: There have been needs to improve the sensitivity of liquid biopsy. This report aims to report the analytical and clinical validation of a next generation sequencing (NGS)-based circulating tumor DNA (ctDNA) assay. MATERIALS AND METHODS: Analytical validation was conducted in vitro by evaluating the limit of detection (LOD), precision, and specificity for various genomic aberrations. The real-world performance in non-small cell lung cancer (NSCLC) was assessed by comparing the results of AlphaLiquid®100 to the tissue-based results...
January 8, 2024: Cancer Research and Treatment: Official Journal of Korean Cancer Association
https://read.qxmd.com/read/38186239/bilateral-seminal-vesicle-invasion-as-a-strong-prognostic-indicator-in-t3b-prostate-cancer-patients-following-radical-prostatectomy-a-comprehensive-multi-center-long-term-follow-up-study
#26
JOURNAL ARTICLE
Jungyo Suh, In Gab Jeong, Hwang Gyun Jeon, Chang Wook Jeong, Sangchul Lee, Seong Soo Jeon, Seok Soo Byun, Cheol Kwak, Hanjong Ahn
PURPOSE: Pathologic T3b (pT3b) prostate cancer, characterized by seminal vesicle invasion (SVI), exhibits variable oncological outcomes post-radical prostatectomy (RP). Identifying prognostic factors is crucial for patient-specific management. This study investigates the impact of bilateral SVI on prognosis in pT3b prostate cancer. MATERIALS AND METHODS: We evaluated the medical records of a multi-institutional cohort of men who underwent RP for prostate cancer with SVI between 2000 and 2012...
January 5, 2024: Cancer Research and Treatment: Official Journal of Korean Cancer Association
https://read.qxmd.com/read/38186241/association-of-immune-related-adverse-events-and-the-efficacy-of-anti-pd-l-1-monotherapy-in-non-small-cell-lung-cancer-adjusting-for-immortal-time-bias
#27
JOURNAL ARTICLE
Ying Yu, Ning Chen, Sizhe Yu, Wanji Shen, Wanchen Zhai, Hui Li, Yun Fan
PURPOSE: The association between immune-related adverse events (irAEs) and survival outcomes in non-small cell lung cancer (NSCLC) patients treated with programmed-death-(ligand)1 [PD-(L)1] inhibitors remains controversial, partly due to variations in dealing with immortal-time bias (ITB). MATERIALS AND METHODS: We retrospectively enrolled 425 advanced NSCLC patients who received anti-PD-(L)1 monotherapy between January 2016 and June 2021, stratifying them into irAE (n=127) and non-irAE (n=298) groups...
January 2, 2024: Cancer Research and Treatment: Official Journal of Korean Cancer Association
https://read.qxmd.com/read/38186240/combined-high-dose-radiotherapy-with-sequential-gemcitabine-cisplatin-based-chemotherapy-increase-the-resectability-and-survival-in-locally-advanced-unresectable-intrahepatic-cholangiocarcinoma-a-multi-institutional-cohort-study
#28
JOURNAL ARTICLE
Jung Ho Im, Jeong Il Yu, Tae Hyun Kim, Tae Gyu Kim, Jun Won Kim, Jinsil Seong
PURPOSE: The locally advanced unresectable intrahepatic cholangiocarcinoma (ICC) has detrimental oncological outcomes. In this study, we aimed to investigate the efficacy of radiotherapy in patients with locally advanced unresectable ICC. MATERIALS AND METHODS: Between 2001 and 2021, 116 patients were identified through medical record who underwent radiotherapy for locally advanced unresectable ICC. The resectability of ICC is determined by the multidisciplinary team at each institution...
January 2, 2024: Cancer Research and Treatment: Official Journal of Korean Cancer Association
https://read.qxmd.com/read/37562437/strategies-to-improve-smoking-cessation-for-participants-in-lung-cancer-screening-program-analysis-of-factors-associated-with-smoking-cessation-in-korean-lung-cancer-screening-project-k-lucas
#29
MULTICENTER STUDY
Yeol Kim, Jaeho Lee, Eunju Lee, Juntae Lim, Yonghyun Kim, Choon-Taek Lee, Seung Hun Jang, Yu-Jin Paek, Won-Chul Lee, Chan Wha Lee, Hyae Young Kim, Jin Mo Goo, Kui Son Choi, Boyoung Park, Duk Hyoung Lee, Hong Gwan Seo
PURPOSE: Smoking cessation intervention is one of the key components of successful lung cancer screening program. We investigated the effectiveness and related factors of smoking cessation services provided to the participants in a population-based lung cancer screening trial. MATERIALS AND METHODS: The Korean Lung Cancer Screening Project (K-LUCAS) is a nationwide, multi-center lung cancer screening trial that evaluates the feasibility of implementing population-based lung cancer screening...
January 2024: Cancer Research and Treatment: Official Journal of Korean Cancer Association
https://read.qxmd.com/read/37402409/first-in-human-phase-1-study-of-a-b-cell-and-monocyte-based-immunotherapeutic-vaccine-against-her2-positive-advanced-gastric-cancer
#30
JOURNAL ARTICLE
Minkyu Jung, Jii Bum Lee, Hyo Song Kim, Woo Sun Kwon, Hyun Ok Kim, Sinyoung Kim, Myunghwan Park, Wuhyun Kim, Ki-Young Choi, Taegwon Oh, Chang-Yuil Kang, Hyun Cheol Chung, Sun Young Rha
PURPOSE: BVAC-B is an autologous B cell- and monocyte-based immunotherapeutic vaccine that contains cells transfected with a recombinant human epidermal growth factor receptor 2 (HER2) gene and loaded with the natural killer T cell ligand alpha-galactosylceramide. Here, we report the first BVAC-B study in patients with HER2-positive advanced gastric cancer. MATERIALS AND METHODS: Patients with advanced gastric cancer refractory to standard treatment with HER2+ immunohistochemistry ≥ 1 were eligible for treatment...
January 2024: Cancer Research and Treatment: Official Journal of Korean Cancer Association
https://read.qxmd.com/read/38186242/the-role-of-early-and-delayed-surgery-for-infants-with-congenital-brain-tumors
#31
JOURNAL ARTICLE
Jong Seok Lee, Ji Yeoun Lee, Kyung Hyun Kim, Sung-Hye Park, Eun Jung Koh, Seung-Ki Kim, Ji Hoon Phi
PURPOSE: The present study aimed to evaluate the role of early and delayed surgery in congenital brain tumors and analyze the clinical outcomes of infantile brain tumors. MATERIALS AND METHODS: We performed a retrospective cohort study on 69 infantile brain tumors at a single institution from January 2008 to June 2023. Outcomes were assessed as early mortality (within 30 days following surgery) to evaluate the risk of early surgery in congenital brain tumors. Outcomes of recurrence and overall survival were analyzed in infantile brain tumors...
December 28, 2023: Cancer Research and Treatment: Official Journal of Korean Cancer Association
https://read.qxmd.com/read/38147817/the-persistence-of-hypertriglyceridemia-and-the-risk-of-early-onset-colorectal-cancer-according-to-tumor-subsites-a-nationwide-population-based-study
#32
JOURNAL ARTICLE
Young Hoon Chang, Cheol Min Shin, Kyungdo Han, Jin Hyung Jung, Eun Hyo Jin, Joo Hyun Lim, Seung Joo Kang, Yoon Jin Choi, Hyuk Yoon, Young Soo Park, Nayoung Kim, Dong Ho Lee
PURPOSE: The incidence of early-onset colorectal cancer (EoCRC) is increasing worldwide. The association between hypertriglyceridemia (HTG) and EoCRC risk remains unclear. MATERIALS AND METHODS: We conducted a nationwide cohort study of 3,340,635 individuals aged 20-49 years who underwent health checkups between 2009 and 2011 under the Korean National Health Insurance Service. HTG was defined as serum triglyceride (TG) level ≥ 150 mg/dL. According to the change in TG status, participants were categorized into persistent normotriglyceridemia (NTG, group 1), NTG to HTG (group 2), HTG to NTG (group 3), and persistent HTG (group 4) groups...
December 20, 2023: Cancer Research and Treatment: Official Journal of Korean Cancer Association
https://read.qxmd.com/read/38147816/trastuzumab-biosimilar-hlx02-pertuzumab-plus-chemotherapy-in-patients-with-her2-positive-metastatic-breast-cancer-after-progression-of-trastuzumab-a-prospective-phase-ii-study
#33
JOURNAL ARTICLE
Ruyan Zhang, Xiaoran Liu, Guohong Song, Yan Zhang, Huiping Li
PURPOSE: This study aims to evaluate the efficacy and safety of trastuzumab biosimilar (HLX02) in combination with pertuzumab and chemotherapy in patients with HER2-positive metastatic breast cancer (MBC) after progression of trastuzumab. MATERIALS AND METHODS: In this prospective, single-arm, phase II study, patients with HER2-positive MBC after progression of tratuzumab received pertuzuamb, HLX02 and chemotherapy (PTC) in Beijing Cancer Hospital from March 2020 to December 2022...
December 20, 2023: Cancer Research and Treatment: Official Journal of Korean Cancer Association
https://read.qxmd.com/read/38147819/secondary-malignancies-in-multiple-myeloma-in-korean-patients-a-nationwide-population-based-study
#34
JOURNAL ARTICLE
Boyoung Park, Eunyoung Lee, Junghyun Yoon, YoungJu Park, Hyeon-Seok Eom
PURPOSE: This study investigated the incidence of secondary malignancy in multiple myeloma (MM) patients compared with that in the general population using a population-based database covering all residents in Korea. MATERIALS AND METHODS: Based on the national health insurance system in Korea, all people primarily diagnosed with MM between January 1, 2010 to December 31, 2018 were identified. A total of 9,985 MM patients aged ≥20 years in Korea were included...
December 18, 2023: Cancer Research and Treatment: Official Journal of Korean Cancer Association
https://read.qxmd.com/read/38147818/invasiveness-of-upper-tract-urothelial-carcinoma-clinical-significance-and-integrative-diagnostic-strategy
#35
JOURNAL ARTICLE
Bokyung Ahn, Doeun Kim, Kye Jin Park, Ja-Min Park, Sun Young Yoon, Bumsik Hong, Yong Mee Cho, Deokhoon Kim
PURPOSE: In this study, we aimed to determine the clinicopathologic, radiologic, and molecular significance of the tumor invasiveness to further stratify the patients with high-grade (HG) upper tract urothelial carcinoma (UTUC) who can be treated less aggressively. MATERIALS AND METHODS: Clinicopathologic and radiologic characteristics of 166 surgically resected HG UTUC (48 non-invasive, and 118 invasive) cases were evaluated. Six non-invasive UTUC cases with intra-tumoral tumor grade heterogeneity were selected for whole exome sequencing (WES) to understand the underlying molecular pathophysiology...
December 18, 2023: Cancer Research and Treatment: Official Journal of Korean Cancer Association
https://read.qxmd.com/read/38097919/the-clinical-efficacy-of-colorectal-cancer-patients-with-pulmonary-oligometastases-by-sterotactic-body-ablative-radiotherapy-a-meta-analysis
#36
JOURNAL ARTICLE
Jae-Uk Jeong, Chai Hong Rim, Gyu Sang Yoo, Won Kyung Cho, Eui Kyu Chie, Yong Chan Ahn, Jong Hoon Lee
PURPOSE: There is increasing interest in the efficacy of stereotactic ablative radiotherapy (SABR) for treating colorectal cancer (CRC) patients with oligometastases (OM), recently. The purpose of this meta-analysis was to evaluate local control (LC), progression-free survival (PFS), and overall survival (OS) of CRC patients with pulmonary OM treated with SABR and toxicities. MATERIALS AND METHODS: Studies that reported SABR for CRC patients with pulmonary OM were searched from MEDLINE and EMBASE...
December 14, 2023: Cancer Research and Treatment: Official Journal of Korean Cancer Association
https://read.qxmd.com/read/38097920/pd-l1-sp142-expression-in-primary-and-recurrent-metastatic-triple-negative-breast-cancers-and-its-clinicopathological-significance
#37
JOURNAL ARTICLE
Eun Kyung Han, Ji Won Woo, Koung Jin Suh, Se Hyun Kim, Jee Hyun Kim, So Yeon Park
PURPOSE: The PD-L1 SP142 assay identifies patients with triple-negative breast cancer (TNBC) who are most likely to respond to the anti-PD-L1 agent atezolizumab. We aimed to compare PD-L1 (SP142) expression between primary and recurrent/metastatic TNBCs and elucidate the clinicopathological features associated with its expression. MATERIALS AND METHODS: Primary and recurrent/metastatic TNBCs tested with PD-L1 (SP142) were collected, and clinicopathological information of these cases was obtained through a review of slides and medical records...
December 12, 2023: Cancer Research and Treatment: Official Journal of Korean Cancer Association
https://read.qxmd.com/read/38097921/assessment-of-bone-marrow-involvement-in-extranodal-nk-t-cell-lymphoma-positron-emission-tomography-versus-bone-marrow-biopsy-and-the-significance-of-minimal-involvement-by-ebv-cells-krog-18-09
#38
JOURNAL ARTICLE
Tae Hoon Lee, Hyun Ju Kim, Jong Hoon Lee, Jeongshim Lee, Jin Hee Kim, Dongryul Oh, Keun-Yong Eom
PURPOSE: This study aims to investigate the diagnostic significance of PET/CT in assessing bone marrow (BM) involvement through a comparison of PET/CT findings with BM biopsy in extranodal NK/T-cell lymphoma. MATERIALS AND METHODS: The medical records of 193 patients were retrospectively reviewed. Patients were categorized as having early-stage (PET-ES) or advanced-stage (PET-AS) disease based on PET/CT results. The BM involvement was classified into three groups according to BM biopsy: gross BM involvement, minimal BM involvement (defined as the presence of a limited number of EBV+ cells in BM), and no involvement...
December 11, 2023: Cancer Research and Treatment: Official Journal of Korean Cancer Association
https://read.qxmd.com/read/38062705/assessment-of-eligibility-and-utilization-of-accelerated-partial-breast-irradiation-apbi-in-korean-breast-cancer-patients-krog-22-15
#39
JOURNAL ARTICLE
Seok-Joo Chun, Ji Hwan Jo, Yong Bae Kim, Sangjoon Park, Sung-Ja Ahn, Su Ssan Kim, Kyubo Kim, Kyung Hwan Shin
PURPOSE: We investigated the proportions of patients eligible for accelerated partial breast irradiation (APBI) among those with pT1-2N0 breast cancer, based on the criteria set by the American Society for Radiation Oncology (ASTRO), the Groupe Européen de Curiethérapie and the European Society for Radiotherapy and Oncology (GEC-ESTRO), the American Brachytherapy Society (ABS), and the American Society of Breast Surgeons (ASBS). Additionally, we analyzed the rate of APBI utilization among eligible patients...
December 8, 2023: Cancer Research and Treatment: Official Journal of Korean Cancer Association
https://read.qxmd.com/read/38062706/a-phase-1b-2a-study-of-gc1118-with-5-fluorouracil-leucovorin-and-irinotecan-folfiri-in-patients-with-recurrent-or-metastatic-colorectal-cancer
#40
JOURNAL ARTICLE
Keun-Wook Lee, Sae-Won Han, Tae Won Kim, Joong Bae Ahn, Ji Yeon Baek, Sang Hee Cho, Howard Lee, Jin Won Kim, Ji-Won Kim, Tae-You Kim, Yong Sang Hong, Seung-Hoon Beom, Yongjun Cha, Yoonjung Choi, Seonhui Kim, Yung-Jue Bang
PURPOSE: GC1118 is a novel antibody targeting epidermal growth factor receptor (EGFR) with enhanced blocking activity against both low- and high-affinity EGFR ligands. A phase 1b/2a study was conducted to determine a recommended phase 2 dose (RP2D) of GC1118 in combination with 5-fluorouracil, leucovorin, and irinotecan (FOLFIRI) (phase 1b) and to assess the safety and efficacy of GC1118 plus FOLFIRI as a second-line therapy for recurrent/metastatic colorectal cancer (CRC) (phase 2a)...
December 7, 2023: Cancer Research and Treatment: Official Journal of Korean Cancer Association
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