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Cancer Research and Treatment: Official Journal of Korean Cancer Association

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https://www.readbyqxmd.com/read/30213181/a-potential-therapy-using-engineered-stem-cells-prevented-malignant-melanoma-in-cellular-and-xenograft-mouse-models
#1
Jae-Rim Heo, Kyung-A Hwang, Seung U Kim, Kyung-Chul Choi
Purpose: In the present study, human neural stem cells (hNSCs) with tumor-tropic behavior were used as drug delivery vehicle to selectively target melanoma. A human neural stem cell line (HB1.F3) was transduced into two types: one expressed only the cytosine deaminase (CD) gene (HB1.F3.CD) and the other expressed both CD and human interferon-β (IFN-β) genes (HB1.F3.CD.IFN-β). Materials and Methods: This study verified the tumor-tropic migratory competence of engineered hNSCs on melanoma (A375SM) using a modified Boyden chamber assay in vitro and CM-DiI staining in vivo...
September 14, 2018: Cancer Research and Treatment: Official Journal of Korean Cancer Association
https://www.readbyqxmd.com/read/30205417/salvage-concurrent-chemo-radiation-therapy-for-loco-regional-recurrence-following-curative-surgery-of-non-small-cell-lung-cancer
#2
Kyung Hwa Lee, Yong Chan Ahn, Hongryull Pyo, Jae Myoung Noh, Seung Gyu Park, Tae Gyu Kim, Eonju Lee, Heerim Nam, Hyebin Lee, Jong-Mu Sun, Jin Seok Ahn, Myung-Ju Ahn, Keunchil Park
Purpose: This study is to report clinical outcomes of salvage concurrent chemo-radiation therapy (CCRT) in treating patients with loco-regional recurrence (LRR) following initial complete resection of non-small cell lung cancer. Materials and Methods: Between February 2004 and December 2016, 127 patients underwent salvage CCRT for LRR. The median radiation therapy (RT) dose was 66 Gy and clinical target volume was to cover recurrent lesion with margin without elective inclusion of regional lymphatics...
September 11, 2018: Cancer Research and Treatment: Official Journal of Korean Cancer Association
https://www.readbyqxmd.com/read/30205416/comparative-effectiveness-of-abdominal-versus-laparoscopic-radical-hysterectomy-for-cervical-cancer-in-the-postdissemination-era
#3
Jin Hee Kim, Kyungjoo Kim, Seo Jin Park, Jung-Yun Lee, Kidong Kim, Myong Cheol Lim, Jae Weon Kim
Purpose: Despite the benefits of minimally invasive surgery for cervical cancer, there are a lack of randomized trials comparing laparoscopic radical hysterectomy and abdominal radical hysterectomy. We compared morbidity, cost of care, and survival between abdominal radical hysterectomy and laparoscopic radical hysterectomy for cervical cancer. Materials and Methods: We used the Korean nationwide database to identify women with cervical cancer who underwent radical hysterectomy from January 1, 2011 to December 31, 2014...
September 11, 2018: Cancer Research and Treatment: Official Journal of Korean Cancer Association
https://www.readbyqxmd.com/read/30189720/application-of-the-international-metastatic-renal-cell-carcinoma-database-consortium-and-memorial-sloan-kettering-cancer-center-risk-models-in-patients-with-metastatic-non-clear-cell-renal-cell-carcinoma-a-multi-institutional-retrospective-study-using-the-korean
#4
Jung Kwon Kim, Sung Han Kim, Mi Kyung Song, Jungnam Joo, Seong Il Seo, Cheol Kwak, Chang Wook Jeong, Cheryn Song, Eu Chang Hwang, Ill Young Seo, Hakmin Lee, Sung-Hoo Hong, Jae Young Park, Jinsoo Chung
Purpose: The International Metastatic Renal Cell Carcinoma Database Consortium (IMDC) and the Memorial Sloan Kettering Cancer Center (MSKCC) risk models were developed predominantly with clear cell renal cell carcinoma. Accordingly, whether these two models could be applied to metastatic non-clear cell RCC (mNCCRCC) as well has not been well-known and was investigated herein. Materials and Methods: From the Korean metastatic RCC registry, a total of 156 patients (8...
September 7, 2018: Cancer Research and Treatment: Official Journal of Korean Cancer Association
https://www.readbyqxmd.com/read/30189719/a-phase-ii-trial-of-osimertinib-in-the-second-line-treatment-of-non-small-cell-lung-cancer-with-the-egfr-t790m-mutation-detected-from-circulating-tumor-dna-liquidlung-o-cohort-2
#5
Cheol-Kyu Park, Hyun-Ju Cho, Yoo-Duk Choi, In-Jae Oh, Young-Chul Kim
Purpose: Administering the best treatment after failure of epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor (TKI) therapy requires knowledge of resistance status. In this trial, treatment efficacy of osimertinib was assessed in patients with non-small cell lung carcinoma (NSCLC) harboring the T790M resistance mutation, detected from circulating tumor DNA (ctDNA) with unknown tumor mutation status. Materials and Methods: To extract ctDNA from plasma, 15 mL of peripheral blood was withdrawn and centrifuged immediately before storage...
September 7, 2018: Cancer Research and Treatment: Official Journal of Korean Cancer Association
https://www.readbyqxmd.com/read/30189722/discordance-of-the-pam50-intrinsic-subtypes-compared-with-ihc-based-surrogate-in-breast-cancer-patients-potential-implication-of-genomic-alterations-of-discordance
#6
Hee Kyung Kim, Kyung Hee Park, Youjin Kim, Song Ee Park, Han Sang Lee, Sung Won Lim, Jang Ho Cho, Ji-Yeon Kim, Jeong Eon Lee, Jin Seok Ahn, Young-Hyuck Im, Jong Han Yu, Yeon Hee Park
Purpose: We aimed to analyze the discordance between immunohistochemistry (IHC)-based surrogate subtyping and PAM50 intrinsic subtypes and to assess overall survival (OS) according to discordance. Materials and Methods: A total of 607 patients were analyzed. Hormone receptor (HR) expression was evaluated by IHC, and human epidermal growth factor receptor 2 (HER2) expression was analyzed by IHC and/or fluorescence in situ hybridization. PAM50 intrinsic subtypes were determined according to 50 cancer genes using the NanoString nCounter Analysis System...
September 5, 2018: Cancer Research and Treatment: Official Journal of Korean Cancer Association
https://www.readbyqxmd.com/read/30189721/genome-wide-association-of-genetic-variation-in-the-psca-gene-with-gastric-cancer-susceptibility-in-a-korean-population
#7
Boyoung Park, Sarah Yang, Jeonghee Lee, Hae Dong Woo, Il Ju Choi, Young Woo Kim, Keun Won Ryu, Young-Il Kim, Jeongseon Kim
Purpose: Half of the world's gastric cancer cases and the highest gastric cancer mortality rates are observed in Eastern Asia. Although several genome-wide association studies (GWASs) have revealed susceptibility genes associated with gastric cancer, no GWASs have been conducted in the Korean population, which has the highest incidence of gastric cancer. Materials and Methods: We performed genome scanning of 450 gastric cancer cases and 1,134 controls via Affymetrix Axiom Exome 319 arrays, followed by replication of 803 gastric cancer cases and 3,693 healthy controls...
September 5, 2018: Cancer Research and Treatment: Official Journal of Korean Cancer Association
https://www.readbyqxmd.com/read/30177584/early-decline-in-left-ventricular-ejection-fraction-can-predict-trastuzumab-related-cardiotoxicity-in-patients-with-breast-cancer-a-study-using-13-years-of-registry-data
#8
Eun Kyoung Kim, Jinhyun Cho, Ji-Yeon Kim, Sung-A Chang, Sung-Ji Park, Jin Oh Choi, Sang Chol Lee, Jin Seok Ahn, Seung Woo Park, Young-Hyuck Im, Eun Seok Jeon, Yeon Hee Park
Purpose: While concerns regarding trastuzumab-related cardiac dysfunction (TRCD) in patients with breast cancer are increasing, there is a lack of evidence supporting the current recommendations for TRCD monitoring. We aimed to investigate the clinical predictors of TRCD in the adjuvant setting of human epidermal growth factor receptor 2-positive breast cancer patients. Materials and Methods: From August 2003 to April 2016, consecutive 998 patients who were treated with adjuvant trastuzumab for breast cancer were retrospectively evaluated...
September 4, 2018: Cancer Research and Treatment: Official Journal of Korean Cancer Association
https://www.readbyqxmd.com/read/30177586/the-endobronchial-ultrasound-guided-transbronchial-needle-aspiration-for-re-biopsy-in-previously-treated-lung-cancer
#9
Joohae Kim, Hyo Jae Kang, Sung Ho Moon, Jong Mog Lee, Hyae Young Kim, Geon-Kook Lee, Jin Soo Lee, Bin Hwangbo
Purpose: Endobronchial ultrasound-guided transbronchial needle aspiration (EBUS-TBNA) is widely used for the diagnosis and staging of lung cancer. However, evidence of its usefulness for re-biopsy in previously treated lung cancer is limited. We evaluated the role of EBUS-TBNA for re-biopsy and its diagnostic yield in patients with different treatment histories. Materials and Methods: We reviewed medical records of patients who underwent EBUS-TBNA for re-biopsy of suspected lesions between January 2006 and December 2016 at the National Cancer Center in South Korea...
September 3, 2018: Cancer Research and Treatment: Official Journal of Korean Cancer Association
https://www.readbyqxmd.com/read/30177585/a-randomized-open-label-phase-ii-study-comparing-pemetrexed-plus-cisplatin-followed-by-maintenance-pemetrexed-versus-pemetrexed-alone-in-patients-with-epidermal-growth-factor-receptor-egfr-mutant-non-small-cell-lung-cancer-after-failure-of-first-line-egfr-tyrosine
#10
Kwai Han Yoo, Su Jin Lee, Jinhyun Cho, Ki Hyeong Lee, Keon Uk Park, Ki Hwan Kim, Eun Kyung Cho, Yoon Hee Choi, Hye Ryun Kim, Hoon-Gu Kim, Heui June Ahn, Ha Yeon Lee, Hwan Jung Yun, Jin-Hyoung Kang, Jaeheon Jeong, Moon Young Choi, Sin-Ho Jung, Jong-Mu Sun, Se-Hoon Lee, Jin Seok Ahn, Keunchil Park, Myung-Ju Ahn
Purpose: The optimal cytotoxic regimens have not been established for patients with non-small cell lung cancer (NSCLC) who develop disease progression on first-line epidermal growth factor receptor tyrosine kinase inhibitor (EGFR-TKI). Materials and Methods: We conducted a multi-center randomized phase II trial to compare the clinical outcomes between pemetrexed plus cisplatin combination therapy followed by maintenance pemetrexed (PC) and pemetrexed monotherapy (P) after failure of first-line EGFR-TKI...
September 3, 2018: Cancer Research and Treatment: Official Journal of Korean Cancer Association
https://www.readbyqxmd.com/read/30134648/the-clinical-value-of-pelp1-for-breast-cancer-a-comparison-with-multiple-cancers-and-analysis-in-breast-cancer-subtypes
#11
Xingen Wang, Julia Y S Tsang, Michelle A Lee, Yun-Bi Ni, Joanna H Tong, Siu-Ki Chan, Sai-Yin Cheung, Ka Fai To, Gary M Tse
Purpose: Proline, glutamic acid, and leucine-rich protein 1 (PELP1), a novel nuclear receptor (NR) co-regulator, is highly expressed in breast cancer. We investigated its expression in breast cancer subtypes, in comparison with other breast markers as well as cancers from different sites. Its prognostic relevance with different subtypes and other NR expression was also examined in breast cancers. Methods: Immunohistochemical analysis was performed on totally 1,944 cancers from six different organs...
August 23, 2018: Cancer Research and Treatment: Official Journal of Korean Cancer Association
https://www.readbyqxmd.com/read/30121968/reduction-of-target-volume-and-the-corresponding-dose-for-the-tumor-regression-field-after-induction-chemotherapy-in-locoregionally-advanced-nasopharyngeal-carcinoma
#12
Lei Wang, Zheng Wu, Dehuan Xie, Ruifang Zeng, Wanqin Cheng, Jiang Hu, Shaomin Huang, Shu Zhou, Rui Zhong, Yong Su
Purpose: This study aims to investigate the feasibility of contouring target volume according to residual tumor and decreasing the dose to the tumor regression field after induction chemotherapy (IC) in locoregionally advanced nasopharyngeal carcinoma (NPC). Materials and Methods: From August 2009 to August 2013, patients with stage III-IVB NPC were treated with IC and concurrent chemoradiotherapy. GTVnx-residual and GTVnd-residual were contoured according to post-IC residual primary tumor and any N+ disease, respectively...
August 13, 2018: Cancer Research and Treatment: Official Journal of Korean Cancer Association
https://www.readbyqxmd.com/read/30121967/disulfiram-a-re-positioned-aldehyde-dehydrogenase-inhibitor-enhances-radiosensitivity-of-human-glioblastoma-cells-in-vitro
#13
Hyeon Kang Koh, Soo Yeon Seo, Jin Ho Kim, Hak Jae Kim, Eui Kyu Chie, Seung-Ki Kim, Il Han Kim
Purpose: Glioblastoma, the most common brain tumor in adults, has poor prognosis. The purpose of this study was to determine the effect of disulfiram (DSF), an aldehyde dehydrogenase inhibitor, on in vitro radiosensitivity of glioblastoma cells with different methylation status of O6-methylguanine-DNA methyltransferase (MGMT) promoter and the underlying mechanism of such effect. Materials and Methods: Five human glioblastoma cells (U138MG, T98G, U251MG, U87MG, and U373MG) and one normal human astrocyte (NHA) cell were cultured and treated with DSF or 6MV x-rays (0, 2, 4, 6, 8 Gy)...
August 13, 2018: Cancer Research and Treatment: Official Journal of Korean Cancer Association
https://www.readbyqxmd.com/read/30092623/prediction-of-acquired-taxane-resistance-using-a-personalized-pathway-based-machine-learning-method
#14
Young Rae Kim, Dongha Kim, Sung Young Kim
Purpose: This study was conducted to develop and validate an individualized prediction model for automated detection of acquired taxane resistance (ATR). Materials and Methods: Penalized regression, combined with an individualized pathway score algorithm, was applied to construct a predictive model using publically available genomic cohorts of ATR and intrinsic taxane resistance (ITR). To develop a model with enhanced generalizability, we merged multiple ATR studies then updated the learning parameter via robust cross-study validation...
August 10, 2018: Cancer Research and Treatment: Official Journal of Korean Cancer Association
https://www.readbyqxmd.com/read/30064198/effect-of-estradiol-in-an-azoxymethane-dextran-sulfate-sodium-treated-mouse-model-of-colorectal-cancer-implication-for-sex-difference-in-colorectal-cancer-development
#15
Hee Jin Son, Sung Hwa Sohn, Nayoung Kim, Ha-Na Lee, Sun Min Lee, Ryoung Hee Nam, Ji Hyun Park, Chin-Hee Song, Eun Shin, Hee Young Na, Joo Sung Kim, Dong Ho Lee, Young-Joon Surh
Purpose: This study demonstrates that estradiol downregulates inflammation and inhibits colorectal cancer (CRC) development in azoxymethane/dextran sulfate sodium (AOM/DSS) mouse model. Materials and Methods: AOM/DSS-treated male and female mice were sacrificed at weeks 2, 10, and 16, to assess estrogen effects on colitis and carcinogenesis. Macroscopic and histologic severity of colitis and Western blot and quantitative real-time polymerase chain reaction were evaluated, to measure inflammatory mediators and cytokines...
August 1, 2018: Cancer Research and Treatment: Official Journal of Korean Cancer Association
https://www.readbyqxmd.com/read/30064197/albumin-to-fibrinogen-ratio-as-an-independent-prognostic-parameter-in-untreated-chronic-lymphocytic-leukemia-a-retrospective-study-of-191-cases
#16
Yi-Xin Zou, Jia Qiao, Hua-Yuan Zhu, Rui-Nan Lu, Yi Xia, Lei Cao, Wei Wu, Hui Jin, Wen-Jie Liu, Jin-Hua Liang, Jia-Zhu Wu, Li Wang, Lei Fan, Wei Xu, Jian-Yong Li
Purpose: Chronic lymphocytic leukemia (CLL) is one of the most frequent type of B-cell chronic lymphoproliferative disorders and chronic inflammation takes part in the development of CLL. However, there has been no valid immune biomarker to predict the prognosis of untreated CLL patients. Materials and Methods: In this retrospective study, we analyzed the clinical correlations and prognostic value of albumin-to-fibrinogen ratio (AFR) detected at diagnosis in 191 CLL patients...
August 1, 2018: Cancer Research and Treatment: Official Journal of Korean Cancer Association
https://www.readbyqxmd.com/read/30064200/prognostic-role-and-clinical-association-of-tumor-infiltrating-lymphocyte-programmed-death-ligand-1-expression-with-neutrophil-lymphocyte-ratio-in-locally-advanced-triple-negative-breast-cancer
#17
Jieun Lee, Dong-Min Kim, Ahwon Lee
Purpose: Tumor-infiltrating lymphocyte (TIL), programmed death-ligand 1 (PD-L1) expression and neutrophil-to-lymphocyte ratio (NLR) is associated to immunogenicity and prognosis of breast cancer. We analyzed baseline NLR, changes of NLR, TIL, and PD-L1 during neoadjuvant chemotherapy (NAC) and their clinical implication in triple-negative breast cancer (TNBC). Materials and Methods: Between January 2008 to December 2015, 358 TNBC patients were analyzed. Baseline NLR, 50 paired NLR (initial diagnosis, after completion of NAC) and 34 paired tissues (initial diagnosis, surgical specimen after completion of NAC) were collected...
July 31, 2018: Cancer Research and Treatment: Official Journal of Korean Cancer Association
https://www.readbyqxmd.com/read/30064199/triumph-trial-one-small-step-could-become-one-giant-leap-for-precision-oncology-in-head-and-neck-cancer
#18
Bhumsuk Keam, Hye Ryun Kim, Hwan Joong Yoon
No abstract text is available yet for this article.
July 31, 2018: Cancer Research and Treatment: Official Journal of Korean Cancer Association
https://www.readbyqxmd.com/read/30049203/clinical-outcomes-of-egfr-exon-20-insertion-mutations-in-advanced-non-small-cell-lung-cancer-in-korea
#19
Seonggyu Byeon, Youjin Kim, Sung Won Lim, Jang Ho Cho, Sehoon Park, Jiyun Lee, Jong-Mu Sun, Yoon-La Choi, Se-Hoon Lee, Jin Seok Ahn, Keunchil Park, Myung-Ju Ahn
Purpose: Epidermal growth factor receptor (EGFR) exon 20 insertion mutations account for approximately 4% of all EGFR mutations. Given the rarity of this mutation, its clinical outcomes are not fully established. Materials and Methods: Between 2009 and 2017, non-small cell lung cancer (NSCLC) patients who showed an exon 20 insertion were retrospectively reviewed for clinical characteristics and outcomes, including responses to chemotherapy (CTx) or targeted therapy...
July 23, 2018: Cancer Research and Treatment: Official Journal of Korean Cancer Association
https://www.readbyqxmd.com/read/30025443/comparison-of-efficacy-of-pembrolizumab-between-epstein-barr-virus%C3%A2-positive-and-%C3%A2-negative-relapsed-or-refractory-non-hodgkin-lymphomas
#20
Seok-Jin Kim, Jiyeon Hyeon, Inju Cho, Young Hyeh Ko, Won Seog Kim
Purpose: Pembrolizumab, a programmed cell death protein 1 (PD1) inhibitor inhibits the interplay between PD1 of T-cell and PD1 ligand 1 (PDL1) on tumor cells. Although pembrolizumab has been tried to various subtypes of non-Hodgkin lymphoma (NHL), real-world data about the efficacy of pembrolizumab in NHL patients are limited. Materials and methods: We analyzed the outcome of 30 relapsed or refractory NHL patients treated with pembrolizumab, and compared the outcome between Epstein-Barr virus (EBV)‒positive and negative subtypes because EBV infection of tumor cells can upregulate PDL1 expression...
July 20, 2018: Cancer Research and Treatment: Official Journal of Korean Cancer Association
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