Coco de Koning, Manon Beekhuijzen, Marysia Tobor-Kapłon, Selinda de Vries-Buitenweg, Dick Schoutsen, Nico Leeijen, Beppy van de Waart, Harry Emmen
The predictability of the zebrafish embryo model is highly influenced by internal exposure of the embryo/larva. As compound uptake is likely to be influenced by factors such as lipophilicity, solvent use, and chorion presence, this article focuses on investigating their effects on compound distribution within the zebrafish embryo. To visualize compound uptake and distribution, zebrafish embryos were exposed for 96 hr, starting at 4 hr postfertilization, to water-soluble dyes: Schiff's reagent (logP -4.63), Giemsa stain (logP -0...
December 2015: Birth Defects Research. Part B, Developmental and Reproductive Toxicology