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Arthritis Research & Therapy

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https://www.readbyqxmd.com/read/29126436/new-insights-on-the-mmp-13-regulatory-network-in-the-pathogenesis-of-early-osteoarthritis
#1
REVIEW
Heng Li, Dan Wang, Yongjian Yuan, Jikang Min
Osteoarthritis (OA) is the most common joint disorder and affects approximately half of the aged population. Current treatments for OA are largely palliative until the articular cartilage has been deeply damaged and irreversible morphological changes appear. Thus, effective methods are needed for diagnosing and monitoring the progression of OA during its early stages when therapeutic drugs or biological agents are most likely to be effective. Various proteinases involved in articular cartilage degeneration in pre-OA conditions, which may represent the earliest reversible measurable changes, are considered diagnostic and therapeutic targets for early OA...
November 10, 2017: Arthritis Research & Therapy
https://www.readbyqxmd.com/read/29126434/whole-blood-microrna-expression-pattern-differentiates-patients-with-rheumatoid-arthritis-their-seropositive-first-degree-relatives-and-healthy-unrelated-control-subjects
#2
Vidyanand Anaparti, Irene Smolik, Xiaobo Meng, Victor Spicer, Neeloffer Mookherjee, Hani El-Gabalawy
BACKGROUND: Epigenetic mechanisms can integrate gene-environment interactions that mediate disease transition from preclinical to clinically overt rheumatoid arthritis (RA). To better understand their role, we evaluated microRNA (miRNA, miR) expression profile in indigenous North American patients with RA who were positive for anticitrullinated protein antibodies; their autoantibody-positive, asymptomatic first-degree relatives (FDRs); and disease-free healthy control subjects (HCs). METHODS: Total RNA was isolated from whole blood samples obtained from HC (n = 12), patients with RA (n = 18), and FDRs (n = 12)...
November 10, 2017: Arthritis Research & Therapy
https://www.readbyqxmd.com/read/29126432/failure-to-achieve-lupus-low-disease-activity-state-lldas-six-months-after-diagnosis-is-associated-with-early-damage-accrual-in-caucasian-patients%C3%A2-with-systemic-lupus-erythematosus
#3
Matteo Piga, Alberto Floris, Giulia Cappellazzo, Elisabetta Chessa, Mattia Congia, Alessandro Mathieu, Alberto Cauli
BACKGROUND: The aim was to assess the attainability and outcome of the lupus low disease activity state (LLDAS) in the early stages of systemic lupus erythematosus (SLE). METHODS: LLDAS prevalence was evaluated at 6 (T1) and 18 (T2) months after diagnosis and treatment initiation (T0) in a monocentric cohort of 107 (median disease duration 9.7 months) prospectively followed Caucasian patients with SLE. Reasons for failure to achieve LLDAS were also investigated...
November 10, 2017: Arthritis Research & Therapy
https://www.readbyqxmd.com/read/29096690/tlr2-stimulation-impairs-anti-inflammatory-activity-of-m2-like-macrophages-generating-a-chimeric-m1-m2-phenotype
#4
Lilian Quero, Edveena Hanser, Tobias Manigold, André N Tiaden, Diego Kyburz
BACKGROUND: Toll-like receptors (TLRs) and macrophages play an important role in rheumatoid arthritis (RA). Currently, it is not clear whether inflammatory M1 or anti-inflammatory M2 predominate among the resident macrophages in the synovium. In the present study, we set out to investigate the impact of TLR stimulation on monocyte-derived M1 and M2 macrophage function and phenotype by mimicking the exposure to abundant TLR agonists as occurs in the context of RA. The response of macrophage subsets to TLR2 and TLR4 activation was evaluated on cluster of differentiation (CD) marker profile; cytokine secretion; gene expression; and NF-κB, interferon regulatory factors 3 and 7 (IRF3/7), and mitogen-activated protein kinase (MAPK) activation...
November 2, 2017: Arthritis Research & Therapy
https://www.readbyqxmd.com/read/29096669/anti-carbamylated-protein-antibodies-precede-disease-onset-in-monkeys-with-collagen-induced-arthritis
#5
Marije K Verheul, Michel P M Vierboom, Bert A 't Hart, Rene E M Toes, Leendert A Trouw
BACKGROUND: Rheumatoid factor (RF), anti-citrullinated protein antibodies (ACPA) and anti-carbamylated protein (anti-CarP) antibodies are rheumatoid arthritis (RA)-associated autoantibodies. Besides their presence in human serum, anti-CarP antibodies have also been described in rodent models of arthritis, while ACPA are not consistently detectable. Data on these RA-associated autoantibodies in primates are not available. Therefore, we investigated the presence of RF, anti-CarP antibodies and ACPA in rhesus monkeys before and after collagen-induced arthritis immunizations...
November 2, 2017: Arthritis Research & Therapy
https://www.readbyqxmd.com/read/29089055/assessing-risk-of-liver-enzyme-elevation-in-patients-with-immune-mediated-diseases-and-different-hepatitis-b-virus-serostatus-receiving-anti-tnf-agents-a-nested-case-control-study
#6
Ying-Ming Chiu, Mei-Shu Lai, K Arnold Chan
BACKGROUND: Liver enzyme elevation is an important and common adverse effect among patients with immune-mediated diseases who receive tumour necrosis factor inhibitors (anti-TNF), and has various causes. Hence, we evaluated the relative risks of developing liver enzyme elevation in anti-TNF users with differing hepatitis B virus (HBV) infection status. METHODS: At a hospital in central Taiwan, 407 patients with rheumatoid arthritis, ankylosing spondylitis, or psoriasis/psoriatic arthritis received anti-TNF therapy between 1 January 2004 and 30 June 2012...
November 1, 2017: Arthritis Research & Therapy
https://www.readbyqxmd.com/read/29065906/biological-function-integrated-prediction-of-severe-radiographic-progression-in-rheumatoid-arthritis-a-nested-case-control-study
#7
Young Bin Joo, Yul Kim, Youngho Park, Kwangwoo Kim, Jeong Ah Ryu, Seunghun Lee, So-Young Bang, Hye-Soon Lee, Gwan-Su Yi, Sang-Cheol Bae
BACKGROUND: Radiographic progression is reported to be highly heritable in rheumatoid arthritis (RA). However, previous study using genetic loci showed an insufficient accuracy of prediction for radiographic progression. The aim of this study is to identify a biologically relevant prediction model of radiographic progression in patients with RA using a genome-wide association study (GWAS) combined with bioinformatics analysis. METHODS: We obtained genome-wide single nucleotide polymorphism (SNP) data for 374 Korean patients with RA using Illumina HumanOmni2...
October 25, 2017: Arthritis Research & Therapy
https://www.readbyqxmd.com/read/29065931/relevance-of-structural-damage-in-the-sacroiliac-joints-for-the-functional-status-and-spinal-mobility-in-patients-with-axial-spondyloarthritis-results-from-the-german-spondyloarthritis-inception-cohort
#8
Mikhail Protopopov, Joachim Sieper, Hildrun Haibel, Joachim Listing, Martin Rudwaleit, Denis Poddubnyy
BACKGROUND: Functional status and spinal mobility in patients with axial spondyloarthritis (axSpA) are known to be determined both by disease activity and by structural damage in the spine. The impact of structural damage in the sacroiliac joints (SIJ) on physical function and spinal mobility in axSpA has not been studied so far. The objective of the study was to analyze the impact of radiographic sacroiliitis on functional status and spinal mobility in patients with axSpA. METHODS: In total, 210 patients with axSpA were included in the analysis...
October 24, 2017: Arthritis Research & Therapy
https://www.readbyqxmd.com/read/29065925/ultrasound-verified-inflammation-and-structural-damage-in-patients-with-hereditary-haemochromatosis-related-arthropathy
#9
Christian Dejaco, Andreas Stadlmayr, Christina Duftner, Viktoria Trimmel, Rusmir Husic, Elisabeth Krones, Shahin Zandieh, Emma Husar-Memmer, Gernot Zollner, Josef Hermann, Judith Gretler, Angelika Lackner, Anja Ficjan, Christian Datz, Roland Axman, Jochen Zwerina
BACKGROUND: Chronic arthropathy occurs in approximately two thirds of patients with hereditary haemochromatosis (HH). The aim was to study inflammatory and structural lesions in patients with HH with (HH-A) and without arthropathy (HH-WA) using ultrasonography. METHODS: This was a cross-sectional study of 26 patients with HH-A, 24 with HH-WA and 37 with hand osteoarthritis (HOA). Clinical examination was performed in 68 joints, and we retrieved data on hand function, pain and global disease activity (all using a visual analogue scale (VAS)), morning stiffness and ferritin levels...
October 24, 2017: Arthritis Research & Therapy
https://www.readbyqxmd.com/read/29065924/dose-response-relationship-between-lower-serum-magnesium-level-and-higher-prevalence-of-knee-chondrocalcinosis
#10
Chao Zeng, Jie Wei, Robert Terkeltaub, Tuo Yang, Hyon K Choi, Yi-Lun Wang, Dong-Xing Xie, David J Hunter, Yuqing Zhang, Hui Li, Yang Cui, Liang-Jun Li, Guang-Hua Lei
BACKGROUND: The aim was to assess serum magnesium levels in relation to prevalence of knee chondrocalcinosis in two population-based Chinese studies. METHODS: Data included in this analysis consisted of two population-based cross-sectional studies, i.e., the Xiangya Hospital Health Management Center Study and the Xiangya Osteoarthritis (XO) Study I. A bilateral knee anteroposterior radiograph was obtained from each subject. Radiographic knee chondrocalcinosis was present if there was definite linear cartilage calcification...
October 24, 2017: Arthritis Research & Therapy
https://www.readbyqxmd.com/read/29065913/urine-s100-proteins-as-potential-biomarkers-of-lupus-nephritis-activity
#11
Jessica L Turnier, Ndate Fall, Sherry Thornton, David Witte, Michael R Bennett, Simone Appenzeller, Marisa S Klein-Gitelman, Alexei A Grom, Hermine I Brunner
BACKGROUND: Improved, noninvasive biomarkers are needed to accurately detect lupus nephritis (LN) activity. The purpose of this study was to evaluate five S100 proteins (S100A4, S100A6, S100A8/9, and S100A12) in both serum and urine as potential biomarkers of global and renal system-specific disease activity in childhood-onset systemic lupus erythematosus (cSLE). METHODS: In this multicenter study, S100 proteins were measured in the serum and urine of four cSLE cohorts and healthy control subjects using commercial enzyme-linked immunosorbent assays...
October 24, 2017: Arthritis Research & Therapy
https://www.readbyqxmd.com/read/29065909/right-drug-right-patient-right-time-aspiration-or-future-promise-for-biologics-in-rheumatoid-arthritis
#12
REVIEW
Vasco C Romão, Edward M Vital, João Eurico Fonseca, Maya H Buch
Individualising biologic disease-modifying anti-rheumatic drugs (bDMARDs) to maximise outcomes and deliver safe and cost-effective care is a key goal in the management of rheumatoid arthritis (RA). Investigation to identify predictive tools of bDMARD response is a highly active and prolific area of research. In addition to clinical phenotyping, cellular and molecular characterisation of synovial tissue and blood in patients with RA, using different technologies, can facilitate predictive testing. This narrative review will summarise the literature for the available bDMARD classes and focus on where progress has been made...
October 24, 2017: Arthritis Research & Therapy
https://www.readbyqxmd.com/read/29065905/severe-intestinal-dysbiosis-is-prevalent-in-primary-sj%C3%A3-gren-s-syndrome-and-is-associated-with-systemic-disease-activity
#13
Thomas Mandl, Jan Marsal, Peter Olsson, Bodil Ohlsson, Kristofer Andréasson
BACKGROUND: Altered microbial composition of the intestine, commonly referred to as dysbiosis, has been associated with several autoimmune diseases including primary Sjögren's syndrome (pSS). The aims of the current study were to study the intestinal microbial balance in pSS and to identify clinical features associated with dysbiosis. METHODS: Forty-two consecutive pSS patients and 35 age-matched and sex-matched control subjects were included in the study in an open clinic setting...
October 24, 2017: Arthritis Research & Therapy
https://www.readbyqxmd.com/read/29065903/changes-in-clinical-disease-activity-are-weakly-linked-to-changes-in-mri-inflammation-on-treat-to-target-escalation-of-therapy-in-rheumatoid-arthritis
#14
Fiona M McQueen, Peter Chapman, Terina Pollock, Dena D'Souza, Arier C Lee, Nicola Dalbeth, Lisa Stamp, Karen Lindsay, Anthony Doyle
BACKGROUND: Rheumatoid arthritis (RA) treat-to-target (T2T) regimens often use the disease activity score (28 joints) incorporating C-reactive protein (DAS28CRP) as an outcome measure. We compared changes in the DAS28CRP with changes in magnetic resonance imaging (MRI) inflammation on treatment escalation. METHODS: Eighty seropositive RA patients with active disease were enrolled. Group A (N = 57) escalated to another conventional disease-modifying therapy (cDMARD) combination, and Group B (N = 23) to anti-TNF therapy/cDMARDs...
October 24, 2017: Arthritis Research & Therapy
https://www.readbyqxmd.com/read/29065901/predictive-biological-markers-of-systemic-lupus-erythematosus-flares-a-systematic-literature-review
#15
Noémie Gensous, Aurélie Marti, Thomas Barnetche, Patrick Blanco, Estibaliz Lazaro, Julien Seneschal, Marie-Elise Truchetet, Pierre Duffau, Christophe Richez
BACKGROUND: The aim of this study was to identify the most reliable biomarkers in the literature that could be used as flare predictors in systemic lupus erythematosus (SLE). METHODS: A systematic review of the literature was performed using two databases (MEDLINE and EMBASE) through April 2015 and congress abstracts from the American College of Rheumatology and the European League Against Rheumatism were reviewed from 2010 to 2014. Two independent reviewers screened titles and abstracts and analysed selected papers in detail, using a specific questionnaire...
October 24, 2017: Arthritis Research & Therapy
https://www.readbyqxmd.com/read/29052537/enhanced-ifn-%C3%AE-production-is-associated-with-increased-tlr7-retention-in-the-lysosomes-of-palasmacytoid-dendritic-cells-in-systemic-lupus-erythematosus
#16
Goh Murayama, Nanako Furusawa, Asako Chiba, Ken Yamaji, Naoto Tamura, Sachiko Miyake
BACKGROUND: Interferon-α (IFN-α) is increased and plays an important role in the pathogenesis of systemic lupus erythematosus (SLE). Plasmacytoid dendritic cells (pDCs) are the main producer of IFN-α, but their IFN-α producing capacity has been shown to be unchanged or reduced when stimulated with a Toll-like receptor 9 (TLR9) agonist in patients with SLE compared to in healthy individuals. In this study, we investigated the IFN-α-producing capacity of lupus pDCs under different stimulation...
October 19, 2017: Arthritis Research & Therapy
https://www.readbyqxmd.com/read/29052524/soluble-cd40l-is-associated-with-increased-oxidative-burst-and-neutrophil-extracellular-trap-release-in-beh%C3%A3-et-s-disease
#17
Sandro Félix Perazzio, Paulo Vitor Soeiro-Pereira, Viviane Cardoso Dos Santos, Marlon Vilela de Brito, Bruno Salu, Maria Luiza Vilela Oliva, Anne Margherite Stevens, Alexandre Wagner Silva de Souza, Hans D Ochs, Troy R Torgerson, Antonio Condino-Neto, Luis Eduardo Coelho Andrade
BACKGROUND: Studies have suggested that soluble factors in plasma from patients with active (aBD) and inactive (iBD) Behçet's disease (BD) stimulate neutrophil function. Soluble CD40 ligand (sCD40L) is an important mediator of inflammation in BD. Its expression and effect on neutrophil oxidative burst and neutrophil extracellular trap (NET) release have not been characterized. In this study, we sought to investigate the role of plasma and the CD40L pathway on NET release and the oxidative burst profile in patients with aBD and iBD...
October 19, 2017: Arthritis Research & Therapy
https://www.readbyqxmd.com/read/29041986/fluorescence-optical-imaging-in-pediatric-patients-with-inflammatory-and-non-inflammatory-joint-diseases-a-comparative-study-with-ultrasonography
#18
Marisa Christin Beck, Anne-Marie Glimm, Sarah Ohrndorf, Kirsten Minden, Ralf Trauzeddel, Stephanie Gabriele Werner, Gerd Horneff, Marina Backhaus, Gerd Rüdiger Burmester, Tilmann Kallinich, Hermann Girschick, Jens Klotsche
BACKGROUND: Valid detection of arthritis is essential in differential diagnosis of joint pain. Indocyanin green (ICG)-enhanced fluorescence optical imaging (FOI) is a new imaging method that visualizes inflammation in wrist and finger joints. Objectives of this study were to compare FOI with ultrasonography (US, by gray-scale (GS) and power Doppler (PD)) and clinical examination (CE) and to estimate the predictive power of FOI for discrimination between inflammatory and non-inflammatory juvenile joint diseases...
October 17, 2017: Arthritis Research & Therapy
https://www.readbyqxmd.com/read/29041979/methotrexate-and-anti-tumor-necrosis-factor-treatment-improves-endothelial-function-in-patients-with-inflammatory-arthritis
#19
Gia Deyab, Ingrid Hokstad, Jon Elling Whist, Milada Cvancarova Smastuen, Stefan Agewall, Torstein Lyberg, Nicoletta Ronda, Knut Mikkelsen, Gunnbjorg Hjeltnes, Ivana Hollan
BACKGROUND: Inflammatory arthritis (IA), including rheumatoid arthritis (RA), ankylosing spondylitis (AS) and psoriatic arthritis (PsA), leads to increased cardiovascular disease occurrence probably due to atherosclerosis. One of the first stages in atherogenesis is endothelial dysfunction (ED). Therefore, we aimed to compare endothelial function (EF) in patients with IA, and to examine the effects of methotrexate (MTX) monotherapy and antitumor necrosis factor (anti-TNF) treatment with or without MTX comedication (anti-TNF ± MTX) on EF...
October 17, 2017: Arthritis Research & Therapy
https://www.readbyqxmd.com/read/29041967/microparticles-from-patients-with-systemic-lupus-erythematosus-induce-production-of-reactive-oxygen-species-and-degranulation-of-polymorphonuclear-leukocytes
#20
Line Kjær Winberg, Søren Jacobsen, Claus H Nielsen
BACKGROUND: The interaction of circulating microparticles (MPs) with immune cells in systemic lupus erythematosus (SLE) is sparsely investigated. We examined the ability of MPs from SLE patients to induce production of reactive oxygen species (ROS) and degranulation of polymorphonuclear leukocytes (PMNs). METHODS: Plasma MPs, leukocytes and sera isolated from 20 SLE patients and 10 healthy controls were mixed in different combinations, with or without lipopolysaccharide (LPS), and incubated for 30 min...
October 17, 2017: Arthritis Research & Therapy
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