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Arthritis Research & Therapy

Jamie C Sergeant, Kimme L Hyrich, James Anderson, Kamilla Kopec-Harding, Holly F Hope, Deborah P M Symmons, Anne Barton, Suzanne M M Verstappen
BACKGROUND: Methotrexate (MTX) remains the disease-modifying anti-rheumatic drug of first choice in rheumatoid arthritis (RA) but response varies. Predicting non-response to MTX could enable earlier access to alternative or additional medications and control of disease progression. We aimed to identify baseline predictors of non-response to MTX and combine these into a prediction algorithm. METHODS: This study included patients recruited to the Rheumatoid Arthritis Medication Study (RAMS), a UK multi-centre prospective observational study of patients with RA or undifferentiated polyarthritis, commencing MTX for the first time...
July 13, 2018: Arthritis Research & Therapy
Maria Karolina Jonsson, Aase Haj Hensvold, Monika Hansson, Anna-Birgitte Aga, Joseph Sexton, Linda Mathsson-Alm, Martin Cornillet, Guy Serre, Siri Lillegraven, Bjørg-Tilde Svanes Fevang, Anca Irinel Catrina, Espen Andre Haavardsholm
BACKGROUND: Anti-citrullinated protein antibody (ACPA) reactivities precede clinical onset of rheumatoid arthritis (RA), and it has been suggested that ACPA reactivities towards distinct target proteins may be associated with differences in RA phenotypes. We aimed to assess the prevalence of baseline ACPA reactivities in an inception cohort of patients with early RA, and to investigate their associations with disease activity, treatment response, ultrasound findings and radiographic damage...
July 13, 2018: Arthritis Research & Therapy
Oh Chan Kwon, Sang-Won Lee, Yong-Beom Park, Ji Seon Oh, Sang Hoon Lee, Seokchan Hong, Chang-Keun Lee, Bin Yoo, Yong-Gil Kim
BACKGROUND: Takayasu arteritis (TAK) is a systemic disease characterized by large vessel involvement. Although the vascular characteristics of TAK are well characterized, there is no well-organized study demonstrating the extravascular manifestations of TAK. We aimed to evaluate the characteristics of extravascular manifestations of TAK, and to identify the association between vascular and extravascular manifestations of TAK. METHODS: TAK patients from two independent cohorts between January 2012 and October 2017 were included in the study...
July 11, 2018: Arthritis Research & Therapy
Yilun Wang, Shuang Chen, Sunyi Chen, Juan Du, Jinran Lin, Haihong Qin, Jie Wang, Jun Liang, Jinhua Xu
BACKGROUND: Monocyte-derived dendritic cells (moDCs) play important roles in the pathogenesis of systemic lupus erythematosus (SLE). Aberrant expression of long noncoding RNAs (lncRNAs) could affect the function of moDCs. The aim of this study was to explore the lncRNA expression profile in moDCs of SLE patients to provide new insights into SLE. METHODS: LncRNA and mRNA microarrays were performed to identify differentially expressed lncRNAs and mRNAs in moDCs of SLE patients compared with normal controls...
July 11, 2018: Arthritis Research & Therapy
Laura T Donlin, Deepak A Rao, Kevin Wei, Kamil Slowikowski, Mandy J McGeachy, Jason D Turner, Nida Meednu, Fumitaka Mizoguchi, Maria Gutierrez-Arcelus, David J Lieb, Joshua Keegan, Kaylin Muskat, Joshua Hillman, Cristina Rozo, Edd Ricker, Thomas M Eisenhaure, Shuqiang Li, Edward P Browne, Adam Chicoine, Danielle Sutherby, Akiko Noma, Chad Nusbaum, Stephen Kelly, Alessandra B Pernis, Lionel B Ivashkiv, Susan M Goodman, William H Robinson, Paul J Utz, James A Lederer, Ellen M Gravallese, Brendan F Boyce, Nir Hacohen, Costantino Pitzalis, Peter K Gregersen, Gary S Firestein, Soumya Raychaudhuri, Larry W Moreland, V Michael Holers, Vivian P Bykerk, Andrew Filer, David L Boyle, Michael B Brenner, Jennifer H Anolik
BACKGROUND: Detailed molecular analyses of cells from rheumatoid arthritis (RA) synovium hold promise in identifying cellular phenotypes that drive tissue pathology and joint damage. The Accelerating Medicines Partnership RA/SLE Network aims to deconstruct autoimmune pathology by examining cells within target tissues through multiple high-dimensional assays. Robust standardized protocols need to be developed before cellular phenotypes at a single cell level can be effectively compared across patient samples...
July 11, 2018: Arthritis Research & Therapy
Pamela F Weiss, Rui Xiao, Timothy G Brandon, David M Biko, Walter P Maksymowych, Robert G Lambert, Jacob L Jaremko, Nancy A Chauvin
BACKGROUND: We aimed to evaluate the diagnostic utility of pelvic radiographs versus magnetic resonance imaging (MRI) of the sacroiliac joints in children with suspected sacroiliitis. METHODS: This was a retrospective cross-sectional study of children with suspected or confirmed spondyloarthritis who underwent pelvic radiograph and MRI within 6 months of one another. Images were scored independently by five raters. Interrater reliability was calculated using Fleiss's kappa coefficient (κ)...
July 11, 2018: Arthritis Research & Therapy
Huai Leng Pisaniello, Susan Lester, David Gonzalez-Chica, Nigel Stocks, Marie Longo, Greg R Sharplin, Eleonora Dal Grande, Tiffany K Gill, Samuel L Whittle, Catherine L Hill
BACKGROUND: Gout has an increasing global prevalence. Underutilization of urate-lowering therapy (ULT) is thought to be common, via both suboptimal dosing and poor medication adherence. The aims of this study were to determine the prevalence of self-reported gout and the key predictors of ULT use in those with gout in a representative population survey in South Australia. METHODS: Data were obtained from the Spring 2015 South Australian Health Omnibus Survey, a multilevel, systematic, survey in a representative population sample involving face-to-face interviews (n = 3005)...
July 11, 2018: Arthritis Research & Therapy
Sizheng Zhao, Daniel Thong, Natasha Miller, Stephen J Duffield, David M Hughes, Laura Chadwick, Nicola J Goodson
BACKGROUND: Depression is common among patients with axial spondyloarthritis (axSpA), but reports of its prevalence are highly variable. We performed a systematic review to (i) describe the prevalence of depression in axSpA, (ii) compare its prevalence between axSpA, ankylosing spondylitis (AS) and non-radiographic axSpA (nr-axSpA) cohorts, and (iii) compare disease activity and functional impairment between those with and without depression. METHODS: We searched Medline, PubMed, Web of Science, PsycINFO, CINAHL Plus, the Cochrane library and conference abstracts of the European League Against Rheumatism, British Society for Rheumatology and American College of Rheumatology using a predefined protocol in accordance with Preferred Reporting Items for Systematic reviews and Meta-Analyses (PRISMA) guidelines...
July 11, 2018: Arthritis Research & Therapy
Benjamin Korman, Roberta Goncalves Marangoni, Gabriel Lord, Jerrold Olefsky, Warren Tourtellotte, John Varga
BACKGROUND: A pivotal role for adipose tissue homeostasis in systemic sclerosis (SSc) skin fibrosis is increasingly recognized. The nuclear receptor PPAR-γ is the master regulator of adipogenesis. Peroxisome proliferator activated receptor-γ (PPAR-γ) has antifibrotic effects by blocking transforming growth factor-β (TGF-β) and is dysregulated in SSc. To unravel the impact of dysregulated PPAR-γ in SSc, we focused on nuclear corepressor (NCoR), which negatively regulates PPAR-γ activity and suppresses adipogenesis...
July 11, 2018: Arthritis Research & Therapy
Qibin Yang, Quanbo Zhang, Yufeng Qing, Li Zhou, Qingsheng Mi, Jingguo Zhou
BACKGROUND: The findings of a previous study by Jin et al. have shown that microRNA (miR)-155 was upregulated in patients with acute gouty arthritis and enhanced the proinflammatory cytokines. There is no direct evidence to support that miR-155 is indeed involved in monosodium urate (MSU)-induced inflammatory responses in vivo. The aim of this study was to investigate the role of miR-155 knock-out (KO) or knock-in (KI) mice in MSU-induced animal models to mimic acute gout. METHODS: MiR-155 expression in cultured bone marrow-derived macrophages (BMDMs) from miR-155 KO, miR-155 KI, and wild-type (WT) mice treated with MSU crystals in vitro was detected by real-time quantitative polymerase chain reaction (qPCR)...
July 11, 2018: Arthritis Research & Therapy
Chia-Chun Tseng, Chung-Jen Chen, Jeng-Hsien Yen, Hsi-Yuan Huang, Jan-Gowth Chang, Shun-Jen Chang, Wei-Ting Liao
BACKGROUND: Accumulating evidence implicates mitochondrial DNA (mtDNA) alleles, which are independent of the nuclear genome, in disease, especially in human metabolic diseases. However, this area of investigation has lagged behind in researching the nuclear alleles in complex traits, for example, in gout. METHODS: Next-generation sequencing was utilized to investigate the relationship between mtDNA alleles and phenotypic variations in 52 male patients with gout and 104 age-matched male non-gout controls from the Taiwan Biobank whole-genome sequencing samples...
July 6, 2018: Arthritis Research & Therapy
Peter L Evans, James A Prior, John Belcher, Christian D Mallen, Charles A Hay, Edward Roddy
BACKGROUND: Gout treatment remains suboptimal. Identifying populations at risk of developing gout may provide opportunities for prevention. Our aim was to assess the risk of incident gout associated with obesity, hypertension and diuretic use. METHODS: We conducted a systematic review and meta-analysis of prospective and retrospective cohort studies in adults (age ≥ 18 years) from primary care or the general population, exposed to obesity, hypertension or diuretic use and with incident gout as their outcome...
July 5, 2018: Arthritis Research & Therapy
Siming Gao, Xiaoxia Zuo, Di Liu, Yizhi Xiao, Honglin Zhu, Huali Zhang, Hui Luo
BACKGROUND: Dermatomyositis and polymyositis are the best known idiopathic inflammatory myopathies (IIMs). Classic histopathologic findings include the infiltration of inflammatory cells into muscle tissues. Neutrophil serine proteinases (NSPs) are granule-associated enzymes and play roles in inflammatory cell migration by increasing the permeability of vascular endothelial cells. In this study, we aimed to find the roles of NSPs in pathogenesis of IIMs. METHODS: RNA and DNA were isolated to measure the relative expression of NSPs and their methylation levels...
July 5, 2018: Arthritis Research & Therapy
April M Jorge, Ronald B Melles, Yuqing Zhang, Na Lu, Sharan K Rai, Lucy H Young, Karen H Costenbader, Rosalind Ramsey-Goldman, S Sam Lim, John M Esdaile, Ann E Clarke, M B Urowitz, Anca Askanase, Cynthia Aranow, Michelle Petri, Hyon Choi
BACKGROUND: Hydroxychloroquine (HCQ) retinopathy may be more common than previously recognized; recent ophthalmology guidelines have revised recommendations from ideal body weight (IBW)-based dosing to actual body weight (ABW)-based dosing. However, contemporary HCQ prescribing trends in the UK remain unknown. METHODS: We examined a UK general population database to investigate HCQ dosing between 2007 and 2016. We studied trends of excess HCQ dosing per ophthalmology guidelines (defined by exceeding 6...
July 5, 2018: Arthritis Research & Therapy
Joseph Hutton, Tahzeeb Fatima, Tanya J Major, Ruth Topless, Lisa K Stamp, Tony R Merriman, Nicola Dalbeth
BACKGROUND: Increased coffee intake is associated with reduced serum urate concentrations and lower risk of gout. Specific alleles of the GCKR, ABCG2, MLXIPL, and CYP1A2 genes have been associated with both reduced coffee intake and increased serum urate in separate genome-wide association studies (GWAS). The aim of this study was to determine whether these single nucleotide polymorphisms (SNPs) influence the risk of gout through their effects on coffee consumption. METHODS: This research was conducted using the UK Biobank Resource...
July 5, 2018: Arthritis Research & Therapy
Lei Zhao, Yasuto Yamaguchi, Xiaomei Ge, William H Robinson, John Morser, Lawrence L K Leung
BACKGROUND: Chemerin is a chemoattractant involved in immunity that also functions as an adipokine. Chemerin is secreted as an inactive precursor (chem163S), and its activation requires proteolytic cleavages at its C-terminus, involving proteases in coagulation, fibrinolysis, and inflammation. Previously, we found chem158K was the dominant chemerin form in synovial fluids from patients with arthritis. In this study, we aimed to characterize a distinct cleaved chemerin form, chem156F, in osteoarthritis (OA) and rheumatoid arthritis (RA)...
July 4, 2018: Arthritis Research & Therapy
Catherine Legrand, Usman Ahmed, Attia Anwar, Kashif Rajpoot, Sabah Pasha, Cécile Lambert, Rose K Davidson, Ian M Clark, Paul J Thornalley, Yves Henrotin, Naila Rabbani
BACKGROUND: Changes of serum concentrations of glycated, oxidized, and nitrated amino acids and hydroxyproline and anticyclic citrullinated peptide antibody status combined by machine learning techniques in algorithms have recently been found to provide improved diagnosis and typing of early-stage arthritis of the knee, including osteoarthritis (OA), in patients. The association of glycated, oxidized, and nitrated amino acids released from the joint with development and progression of knee OA is unknown...
June 22, 2018: Arthritis Research & Therapy
Yu-Lan Chen, Jun Jing, Ying-Qian Mo, Jian-Da Ma, Li-Juan Yang, Le-Feng Chen, Xiang Zhang, Tao Yan, Dong-Hui Zheng, Frank Pessler, Lie Dai
BACKGROUND: Previous studies have revealed that hepatitis B virus (HBV) infection may be related to rheumatoid arthritis (RA), but there are no studies on the presence of HBV antigens or nucleic acid in synovium from patients with RA with HBV infection. In the present study, we investigated the presence of HBV in the synovium and its clinical significance in RA. METHODS: Fifty-seven consecutive patients with active RA (Disease Activity Score 28-joint assessment based on C-reactive protein ≥ 2...
June 19, 2018: Arthritis Research & Therapy
Vibeke Strand, Laure Gossec, Clare W J Proudfoot, Chieh-I Chen, Matthew Reaney, Sophie Guillonneau, Toshio Kimura, Janet van Adelsberg, Yong Lin, Erin K Mangan, Hubert van Hoogstraten, Gerd R Burmester
BACKGROUND: The phase III MONARCH randomized controlled trial (NCT02332590) demonstrated that in patients with rheumatoid arthritis (RA), sarilumab (anti-interleukin-6 receptor monoclonal antibody) monotherapy is superior to adalimumab monotherapy in reducing disease activity and signs and symptoms of RA, as well as in improving physical function, with similar rates of adverse and serious adverse events. We report the effects of sarilumab versus adalimumab on patient-reported outcomes (PROs)...
June 19, 2018: Arthritis Research & Therapy
Yalong Di, Changxu Han, Liang Zhao, Yizhong Ren
BACKGROUND: In this study, we evaluated whether platelet-rich plasma (PRP) is superior to hyaluronic acid (HA) in the treatment of knee osteoarthritis. METHODS: The Cochrane Central Register of Controlled Trials, PubMed, and Embase databases were searched for English-language, human in vivo studies on the treatment of symptomatic knee osteoarthritis with intra-articular PRP compared with HA. The following keywords were used for the search: "platelet-rich plasma," "PRP," "platelet-rich fibrin," "PRF," "platelet," "plasma," "arthritis," "osteoarthritis," "gonarthrosis," and "degeneration...
June 19, 2018: Arthritis Research & Therapy
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