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Arthritis Research & Therapy

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https://www.readbyqxmd.com/read/29724251/meta-analysis-of-gwas-on-both-chinese-and-european-populations-identifies-gpr173-as-a-novel-x-chromosome-susceptibility-gene-for-sle
#1
Huoru Zhang, Yan Zhang, Yong-Fei Wang, David Morris, Nattiya Hirankarn, Yujun Sheng, Jiangshan Shen, Hai-Feng Pan, Jing Yang, Sen Yang, Yong Cui, Dong-Qing Ye, Timothy J Vyse, Xuejun Zhang, Yu Lung Lau, Wanling Yang
BACKGROUND: Systemic lupus erythematous (SLE) is a complex autoimmune disease with female predominance, particularly affecting those of childbearing age. We performed analysis of three genome-wide genotyping datasets of populations of both Chinese and European origin. METHODS: This study involved 5695 cases and 10,357 controls in the discovery stage. The lead signal on chromosome X was followed by replication in three additional Asian cohorts, with 2300 cases and 4244 controls in total...
May 3, 2018: Arthritis Research & Therapy
https://www.readbyqxmd.com/read/29724250/does-information-on-novel-identified-autoantibodies-contribute-to-predicting-the-progression-from-undifferentiated-arthritis-to-rheumatoid-arthritis-a-study-on-anti-carp-antibodies-as-an-example
#2
Debbie M Boeters, Leendert A Trouw, Annette H M van der Helm-van Mil, Hanna W van Steenbergen
BACKGROUND: The presence of autoantibodies is considered an important characteristic of rheumatoid arthritis (RA); therefore, both anticitrullinated protein antibodies (ACPA) and rheumatoid factor (RF) are included in the 2010 classification criteria for rheumatoid arthritis (RA). However, a considerable number of RA patients lack both these autoantibodies. Recently, several novel autoantibodies have been identified but their value for the classification of RA patients is unclear. Therefore, we studied the value of novel autoantibodies using the presence of anticarbamylated protein (anti-CarP) antibodies as an example for predicting RA development in patients with undifferentiated arthritis (UA)...
May 3, 2018: Arthritis Research & Therapy
https://www.readbyqxmd.com/read/29724248/predicting-unfavorable-long-term-outcome-in-juvenile-idiopathic-arthritis-results-from-the-nordic-cohort-study
#3
Veronika Rypdal, Ellen Dalen Arnstad, Kristiina Aalto, Lillemor Berntson, Maria Ekelund, Anders Fasth, Mia Glerup, Troels Herlin, Susan Nielsen, Suvi Peltoniemi, Marek Zak, Marite Rygg, Martin Rypdal, Ellen Nordal
BACKGROUND: The aim was to develop prediction rules that may guide early treatment decisions based on baseline clinical predictors of long-term unfavorable outcome in juvenile idiopathic arthritis (JIA). METHODS: In the Nordic JIA cohort, we assessed baseline disease characteristics as predictors of the following outcomes 8 years after disease onset. Non-achievement of remission off medication according to the preliminary Wallace criteria, functional disability assessed by Childhood Health Assessment Questionnaire (CHAQ) and Physical Summary Score (PhS) of the Child Health Questionnaire, and articular damage assessed by the Juvenile Arthritis Damage Index-Articular (JADI-A)...
May 3, 2018: Arthritis Research & Therapy
https://www.readbyqxmd.com/read/29724244/does-psychological-stress-in-patients-with-clinically-suspect-arthralgia-associate-with-subclinical-inflammation-and-progression-to-inflammatory-arthritis
#4
Aleid C Boer, Robin M Ten Brinck, Andrea W M Evers, Annette H M van der Helm-van Mil
BACKGROUND: Within established rheumatoid arthritis (RA), stress can have pro-inflammatory effects by activating the immune system via the hypothalamic-pituitary-adrenal axis and the autonomic nervous system. It is unknown if stress levels also promote inflammation during RA development. We studied whether the psychological stress response was increased in clinically suspect arthralgia (CSA) and if this associated with inflammation at presentation with arthralgia and with progression to clinical arthritis...
May 3, 2018: Arthritis Research & Therapy
https://www.readbyqxmd.com/read/29720278/untangling-the-complex-relationships-between-incident-gout-risk-serum-urate-and-its-comorbidities
#5
Mengying Sun, Ana I Vazquez, Richard J Reynolds, Jasvinder A Singh, Mathew Reeves, Tony R Merriman, Angelo L Gaffo, Gustavo de Los Campos
BACKGROUND: Many gout comorbidities (e.g., hypertension) are correlated with serum urate. In this investigation, we identified risk factors (e.g., systolic blood pressure [SBP]), that (1) are associated with incident gout, (2) have effects on gout risk that cannot be fully explained by correlated differences in serum urate, and (3) may modulate the relationship between gout and serum urate. METHODS: Using data from the Atherosclerosis Risk in Communities (ARIC) study, we estimated the unadjusted associations between gout and risk factors by calculating ORs and using chi-square tests...
May 3, 2018: Arthritis Research & Therapy
https://www.readbyqxmd.com/read/29720256/inflammation-functions-as-a-key-mediator-in-the-link-between-acpa-and-erosion-development-an-association-study-in-clinically-suspect-arthralgia
#6
R M Ten Brinck, R E M Toes, A H M van der Helm-van Mil
BACKGROUND: Anti-citrullinated protein antibodies (ACPA) are associated with more severe joint erosions in rheumatoid arthritis (RA), but the underlying mechanism is unclear. Recent in vitro and murine studies indicate that ACPAs can directly activate osteoclasts leading to bone erosions and pain. This study sought evidence for this hypothesis in humans and evaluated whether in patients with arthralgia who are at risk of RA, ACPA is associated with erosions (detected by magnetic resonance imaging (MRI)) independent of inflammation, and also independent of the presence of rheumatoid factor (RF)...
May 3, 2018: Arthritis Research & Therapy
https://www.readbyqxmd.com/read/29720262/upper-zone-of-growth-plate-and-cartilage-matrix-associated-protein-protects-cartilage-during-inflammatory-arthritis
#7
Fritz Seuffert, Daniela Weidner, Wolfgang Baum, Georg Schett, Michael Stock
BACKGROUND: ADAMTS aggrecanases play a major role in cartilage degeneration during degenerative and inflammatory arthritis. The cartilage-specific secreted protein Upper zone of growth plate and cartilage matrix associated protein (Ucma) has been shown to block ADAMTS-triggered aggrecanolysis in experimental osteoarthritis. Here we aimed to investigate whether and how Ucma may affect cartilage destruction and osteophyte formation in the context of inflammatory arthritis. METHODS: Ucma-ADAMTS5 protein interactions were studied using slot blot and solid phase binding assays...
May 2, 2018: Arthritis Research & Therapy
https://www.readbyqxmd.com/read/29720260/smoking-body-mass-index-disease-activity-and-the-risk-of-rapid-radiographic-progression-in-patients-with-early-rheumatoid-arthritis
#8
Emil Rydell, Kristina Forslind, Jan-Åke Nilsson, Lennart T H Jacobsson, Carl Turesson
BACKGROUND: Identification of risk factors for rapid joint destruction in early rheumatoid arthritis (RA) can be helpful for optimizing treatment, and improving our understanding of destructive arthritis and its mechanisms. The objective of this study was to investigate the relationship between early RA patient characteristics and subsequent rapid radiographic progression (RRP). METHODS: An inception cohort of patients with early RA (symptom duration < 12 months), recruited during 1995-2005 from a defined area (Malmö, Sweden), was investigated...
May 2, 2018: Arthritis Research & Therapy
https://www.readbyqxmd.com/read/29720252/estrogen-induces-st6gal1-expression-and-increases-igg-sialylation-in-mice-and-patients-with-rheumatoid-arthritis-a-potential-explanation-for-the-increased-risk-of-rheumatoid-arthritis-in-postmenopausal-women
#9
Cecilia Engdahl, Albert Bondt, Ulrike Harre, Jasmin Raufer, René Pfeifle, Alessandro Camponeschi, Manfred Wuhrer, Michaela Seeling, Inga-Lill Mårtensson, Falk Nimmerjahn, Gerhard Krönke, Hans U Scherer, Helena Forsblad-d'Elia, Georg Schett
BACKGROUND: Rheumatoid arthritis (RA) preferentially affects women, with the peak incidence coinciding with estrogen decrease in menopause. Estrogen (E2) may therefore have intrinsic immune-regulatory properties that vanish with menopause. Fc sialylation is a crucial factor determining the inflammatory effector function of antibodies. We therefore analyzed whether E2 affects immunoglobulin G (IgG) sialylation. METHODS: Postmenopausal (ovariectomized) mice were immunized with ovalbumin and treated with E2 or vehicle...
May 2, 2018: Arthritis Research & Therapy
https://www.readbyqxmd.com/read/29720243/fc%C3%AE-receptor-mediated-influx-of-s100a8-a9-producing-neutrophils-as-inducer-of-bone-erosion-during-antigen-induced-arthritis
#10
Irene Di Ceglie, Giuliana Ascone, Niels A J Cremers, Annet W Sloetjes, Birgitte Walgreen, Thomas Vogl, Johannes Roth, J Sjef Verbeek, Fons A J van de Loo, Marije I Koenders, Peter M van der Kraan, Arjen B Blom, Martijn H J van den Bosch, Peter L E M van Lent
BACKGROUND: Osteoclast-mediated bone erosion is a central feature of rheumatoid arthritis (RA). Immune complexes, present in a large percentage of patients, bind to Fcγ receptors (FcγRs), thereby modulating the activity of immune cells. In this study, we investigated the contribution of FcγRs, and FcγRIV in particular, during antigen-induced arthritis (AIA). METHODS: AIA was induced in knee joints of wild-type (WT), FcγRI,II,III-/- , and FcγRI,II,III,IV-/- mice...
May 2, 2018: Arthritis Research & Therapy
https://www.readbyqxmd.com/read/29720240/integrative-analysis-reveals-cd38-as-a-therapeutic-target-for-plasma-cell-rich-pre-disease-and-established-rheumatoid-arthritis-and-systemic-lupus-erythematosus
#11
Suzanne Cole, Alice Walsh, Xuefeng Yin, Mihir D Wechalekar, Malcolm D Smith, Susanna M Proudman, Douglas J Veale, Ursula Fearon, Costantino Pitzalis, Frances Humby, Michele Bombardieri, Amy Axel, Homer Adams, Christopher Chiu, Michael Sharp, John Alvarez, Ian Anderson, Loui Madakamutil, Sunil Nagpal, Yanxia Guo
BACKGROUND: Plasmablasts and plasma cells play a key role in many autoimmune diseases, such as rheumatoid arthritis (RA) and systemic lupus erythematosus (SLE). This study was undertaken to evaluate the potential of targeting CD38 as a plasma cell/plasmablast depletion mechanism by daratumumab in the treatment of patients with RA and SLE. METHODS: RNA-sequencing analysis of synovial biopsies from various stages of RA disease progression, flow cytometry analysis of peripheral blood mononuclear cells (PBMC) from patients with RA or SLE and healthy donors, immunohistochemistry assessment (IHC) of synovial biopsies from patients with early RA, and ex vivo immune cell depletion assays using daratumumab (an anti-CD38 monoclonal antibody) were used to assess CD38 as a therapeutic target...
May 2, 2018: Arthritis Research & Therapy
https://www.readbyqxmd.com/read/29720237/factors-associated-with-physicians-prescriptions-for-rheumatoid-arthritis-drugs-not-filled-by-patients
#12
Hong J Kan, Kirill Dyagilev, Peter Schulam, Suchi Saria, Hadi Kharrazi, David Bodycombe, Charles T Molta, Jeffrey R Curtis
BACKGROUND: This study estimated the extent and predictors of primary nonadherence (i.e., prescriptions made by physicians but not initiated by patients) to methotrexate and to biologics or tofacitinib in rheumatoid arthritis (RA) patients who were newly prescribed these medications. METHODS: Using administrative claims linked with electronic health records (EHRs) from multiple healthcare provider organizations in the USA, RA patients who received a new prescription for methotrexate or biologics/tofacitinib were identified from EHRs...
May 2, 2018: Arthritis Research & Therapy
https://www.readbyqxmd.com/read/29720236/accuracy-of-the-humasens-plus-point-of-care-uric-acid-meter-using-capillary-blood-obtained-by-fingertip-puncture
#13
Stéphanie Fabre, Pierre Clerson, Jean-Marie Launay, Jean-François Gautier, Tiphaine Vidal-Trecan, Jean-Pierre Riveline, Adam Platt, Anna Abrahamsson, Jeffrey N Miner, Glen Hughes, Pascal Richette, Thomas Bardin
BACKGROUND: The uric acid (UA) level in patients with gout is a key factor in disease management and is typically measured in the laboratory using plasma samples obtained after venous puncture. This study aimed to assess the reliability of immediate UA measurement with capillary blood samples obtained by fingertip puncture with the HumaSensplus point-of-care meter. METHODS: UA levels were measured using both the HumaSensplus meter in the clinic and the routine plasma UA method in the biochemistry laboratory of 238 consenting diabetic patients...
May 2, 2018: Arthritis Research & Therapy
https://www.readbyqxmd.com/read/29720235/effects-of-selexipag-and-its-active-metabolite-in-contrasting-the-profibrotic-myofibroblast-activity-in-cultured-scleroderma-skin-fibroblasts
#14
Maurizio Cutolo, Barbara Ruaro, Paola Montagna, Renata Brizzolara, Emanuela Stratta, Amelia Chiara Trombetta, Stefano Scabini, Pier Paolo Tavilla, Aurora Parodi, Claudio Corallo, Nicola Giordano, Sabrina Paolino, Carmen Pizzorni, Alberto Sulli, Vanessa Smith, Stefano Soldano
BACKGROUND: Myofibroblasts contribute to fibrosis through the overproduction of extracellular matrix (ECM) proteins, primarily type I collagen (COL-1) and fibronectin (FN), a process which is mediated in systemic sclerosis (SSc) by the activation of fibrogenic intracellular signaling transduction molecules, including extracellular signal-regulated kinases 1 and 2 (Erk1/2) and protein kinase B (Akt). Selexipag is a prostacyclin receptor agonist synthesized for the treatment of pulmonary arterial hypertension...
May 2, 2018: Arthritis Research & Therapy
https://www.readbyqxmd.com/read/29720234/two-independent-proteomic-approaches-provide-a-comprehensive-analysis-of-the-synovial-fluid-proteome-response-to-autologous-chondrocyte-implantation
#15
Charlotte H Hulme, Emma L Wilson, Heidi R Fuller, Sally Roberts, James B Richardson, Pete Gallacher, Mandy J Peffers, Sally L Shirran, Catherine H Botting, Karina T Wright
BACKGROUND: Autologous chondrocyte implantation (ACI) has a failure rate of approximately 20%, but it is yet to be fully understood why. Biomarkers are needed that can pre-operatively predict in which patients it is likely to fail, so that alternative or individualised therapies can be offered. We previously used label-free quantitation (LF) with a dynamic range compression proteomic approach to assess the synovial fluid (SF) of ACI responders and non-responders. However, we were able to identify only a few differentially abundant proteins at baseline...
May 2, 2018: Arthritis Research & Therapy
https://www.readbyqxmd.com/read/29720229/early-achievement-of-deep-remission-predicts-low-incidence-of-renal-flare-in-lupus-nephritis-class-iii-or-iv
#16
LETTER
Hironari Hanaoka, Harunobu Iida, Tomofumi Kiyokawa, Yukiko Takakuwa, Kimito Kawahata
No abstract text is available yet for this article.
May 2, 2018: Arthritis Research & Therapy
https://www.readbyqxmd.com/read/29720222/targeted-lipidomics-analysis-identified-altered-serum-lipid-profiles-in-patients-with-polymyositis-and-dermatomyositis
#17
Joan Raouf, Helena Idborg, Petter Englund, Helene Alexanderson, Maryam Dastmalchi, Per-Johan Jakobsson, Ingrid E Lundberg, Marina Korotkova
BACKGROUND: Polymyositis (PM) and dermatomyositis (DM) are severe chronic autoimmune diseases, characterized by muscle fatigue and low muscle endurance. Conventional treatment includes high doses of glucocorticoids and immunosuppressive drugs; however, few patients recover full muscle function. One explanation of the persistent muscle weakness could be altered lipid metabolism in PM/DM muscle tissue as we previously reported. Using a targeted lipidomic approach we aimed to characterize serum lipid profiles in patients with PM/DM compared to healthy individuals (HI) in a cross-sectional study...
May 2, 2018: Arthritis Research & Therapy
https://www.readbyqxmd.com/read/29720221/deleterious-role-of-hepatitis-b-virus-infection-in-therapeutic-response-among-patients-with-rheumatoid-arthritis-in-a-clinical-practice-setting-a-case-control-study
#18
Yu-Lan Chen, Jian-Zi Lin, Ying-Qian Mo, Jian-Da Ma, Qian-Hua Li, Xiao-Ying Wang, Ze-Hong Yang, Tao Yan, Dong-Hui Zheng, Lie Dai
BACKGROUND: Previous studies have revealed that hepatitis B virus (HBV) infection may be associated with rheumatoid arthritis (RA), while there are no further clinical studies regarding the role of HBV infection in RA progression during disease-modifying anti-rheumatic drug (DMARD) therapy. Here, we aimed to explore the influence of HBV infection on radiographic and clinical outcomes among patients with RA in a clinical practice setting. METHODS: Thirty-two consecutive patients with RA (Disease Activity Score 28-joint assessment based on C-reactive protein (DAS28-CRP) ≥2...
May 2, 2018: Arthritis Research & Therapy
https://www.readbyqxmd.com/read/29669593/association-between-general-joint-hypermobility-and-knee-hip-and-lumbar-spine-osteoarthritis-by-race-a-cross-sectional-study
#19
Portia P E Flowers, Rebecca J Cleveland, Todd A Schwartz, Amanda E Nelson, Virginia B Kraus, Howard J Hillstrom, Adam P Goode, Marian T Hannan, Jordan B Renner, Joanne M Jordan, Yvonne M Golightly
BACKGROUND: Osteoarthritis (OA) prevalence differs by race. General joint hypermobility (GJH) may be associated with OA, but differences by race are not known. This community-based study examined the frequency of GJH and its relationship with knee, hip, and lumbar spine OA by race (African American vs. Caucasian). METHODS: Data were from the Johnston County OA project, collected 2003-2010. GJH was defined as Beighton score ≥4. OA symptoms were defined as the presence of pain, aching, or stiffness on most days separately at the knee, hip, and lower back...
April 18, 2018: Arthritis Research & Therapy
https://www.readbyqxmd.com/read/29669578/characterization-of-inflammatory-cell-infiltrate-of-scleroderma-skin-b-cells-and-skin-score-progression
#20
Silvia Bosello, Cristiana Angelucci, Gina Lama, Stefano Alivernini, Gabriella Proietti, Barbara Tolusso, Gigliola Sica, Elisa Gremese, Gianfranco Ferraccioli
BACKGROUND: The purpose of this study was to investigate the frequency and the distribution of inflammatory cell infiltrate in two sets of cutaneous biopsies derived from clinically affected and unaffected skin in patients with systemic sclerosis (SSc) and to test correlation between the cell infiltrate and the progression of skin involvement. METHODS: Skin was immunohistochemically assessed to identify CD68, CD3, CD20 and CD138-positive (+) cells in clinically affected and unaffected skin in 28 patients with SSc...
April 18, 2018: Arthritis Research & Therapy
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