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Arthritis Research & Therapy

Anna Szeremeta, Agnieszka Jura-Półtorak, Ewa Maria Koźma, Andrzej Głowacki, Eugeniusz Józef Kucharz, Magdalena Kopeć-Mędrek, Krystyna Olczyk
BACKGROUND: In this study, the effect of 15-month anti-tumor necrosis factor alpha (TNF-α) treatment on circulating levels of plasma sulfated glycosaminoglycans (GAGs) and the nonsulfated GAG hyaluronic acid (HA) in female rheumatoid arthritis (RA) patients was assessed. METHODS: Plasma was obtained from healthy subjects and RA women treated with TNF-α antagonists (etanercept or adalimumab or certolizumab pegol) in combination with methotrexate. GAGs were isolated from plasma samples using ion exchange low-pressure liquid chromatography...
September 18, 2018: Arthritis Research & Therapy
Tristan Pascart, Agathe Grandjean, Benoist Capon, Julie Legrand, Nasser Namane, Vincent Ducoulombier, Marguerite Motte, Marie Vandecandelaere, Hélène Luraschi, Catherine Godart, Eric Houvenagel, Laurène Norberciak, Jean-François Budzik
BACKGROUND: Predicting the risk of flares in patients with gout is a challenge and the link between urate burden and the risk of gout flare is unclear. The objective of this study was to determine if the extent of monosodium urate (MSU) burden measured with dual-energy computed tomography (DECT) and ultrasonography (US) is predictive of the risk of gout flares. METHODS: This prospective observational study recruited patients with gout to undergo MSU burden assessment with DECT (volume of deposits) and US (double contour sign) scans of the knees and feet...
September 17, 2018: Arthritis Research & Therapy
Robert Landewé, Tommi Nurminen, Owen Davies, Dominique Baeten
BACKGROUND: To be eligible to receive treatment with an anti-tumour necrosis factor (TNF), non-radiographic axial spondyloarthritis (nr-axSpA) patients require either elevated levels of C-reactive protein (CRP) (CRP > upper limit of normal (ULN)) or magnetic resonance imaging assessment showing inflammation of the sacroiliac joints, in addition to meeting criteria for high disease activity. Many axSpA patients are classified as 'CRP-negative', or CRP normal, despite having levels close to the ULN, and are therefore formally ineligible for treatment...
September 14, 2018: Arthritis Research & Therapy
Zhi-Feng Xiao, Jian-Bo He, Guo-Yi Su, Mei-Hui Chen, Yu Hou, Shu-Dong Chen, Ding-Kun Lin
BACKGROUND: Studies on the relationship between osteoporosis and intervertebral disc degeneration (IVDD) are inconsistent. Therefore, we assessed whether IVDD is affected by vertebral osteoporosis in ovariectomized mice and investigated the underlying pathogenesis of IVDD related to osteoporosis. METHODS: Thirty healthy female C57BL/6 J mice aged 8 weeks were randomly divided into two groups: a control group (sham operation, n = 15) and an ovariectomy group (OVX; bilateral ovariectomy, n = 15)...
September 10, 2018: Arthritis Research & Therapy
Ashika Chhana, Bregina Pool, Karen E Callon, Mei Lin Tay, David Musson, Dorit Naot, Geraldine McCarthy, Susan McGlashan, Jillian Cornish, Nicola Dalbeth
BACKGROUND: Bone erosion is a frequent complication of gout and is strongly associated with tophi, which are lesions comprising inflammatory cells surrounding collections of monosodium urate (MSU) crystals. Osteocytes are important cellular mediators of bone remodeling. The aim of this study was to investigate the direct effects of MSU crystals and indirect effects of MSU crystal-induced inflammation on osteocytes. METHODS: For direct assays, MSU crystals were added to MLO-Y4 osteocyte cell line cultures or primary mouse osteocyte cultures...
September 10, 2018: Arthritis Research & Therapy
Panagiota Drivelegka, Valgerdur Sigurdardottir, Anna Svärd, Lennart T H Jacobsson, Mats Dehlin
Unfortunately, after publication of this article [1], it was noticed that Fig. 2 is incorrect.
September 10, 2018: Arthritis Research & Therapy
Xiuhong Weng, Yi Liu, Shun Cui, Bo Cheng
BACKGROUND: The orphan nuclear receptors retinoic acid-related receptor α and γt (RORα and RORγt) are critical in the development of T helper 17 (Th17) cells, and ROR-specific synthetic ligands have proven efficacy in several mouse models of autoimmunity. However, the pathological significance of RORα in primary Sjögren's syndrome (pSS) remains to be elucidated. The present study was designed to clarify the significance of RORα in the pathogenesis of pSS. METHODS: RORα expression in the labial salivary gland (LSG) was determined by immunohistochemical analysis using a quantitative scoring system in 34 patients with pSS...
September 6, 2018: Arthritis Research & Therapy
Charles McWherter, Yun-Jung Choi, Ramon L Serrano, Sushil K Mahata, Robert Terkeltaub, Ru Liu-Bryan
BACKGROUND: Arhalofenate acid, the active acid form of arhalofenate, is a non-agonist peroxisome proliferator-activated receptor γ (PPARγ) ligand, with uricosuric activity via URAT1 inhibition. Phase II studies revealed decreased acute arthritis flares in arhalofenate-treated gout compared with allopurinol alone. Hence, we investigated the anti-inflammatory effects and mechanisms of arhalofenate and its active acid form for responses to monosodium urate (MSU) crystals. METHODS: We assessed in-vivo responses to MSU crystals in murine subcutaneous air pouches and in-vitro responses in murine bone marrow-derived macrophages (BMDMs) by enzyme-linked immunosorbent assay (ELISA), SDS-PAGE/Western blot, immunostaining, and transmission electron microscopy analyses...
September 6, 2018: Arthritis Research & Therapy
David Simon, Arnd Kleyer, Francesca Faustini, Matthias Englbrecht, Judith Haschka, Andreas Berlin, Sebastian Kraus, Axel J Hueber, Roland Kocijan, Michael Sticherling, Juergen Rech, Georg Schett
BACKGROUND: Comprehensive simultaneous quantification of bone erosion and enthesiophytes in the joints of patients with psoriatic arthritis (PsA) has not been performed. Herein, we aimed to compare the extent of bone erosion and enthesiophytes in patients with PsA, psoriasis (PSO) and healthy controls, assess the influence of age and disease duration on the development of erosions and enthesiophytes and define their impact on physical function. METHODS: Patients with PsA or with PSO and controls were analysed by high-resolution peripheral quantitative computed tomography (HR-pQCT)...
August 31, 2018: Arthritis Research & Therapy
Anna Neumann, Judith Haschka, Arnd Kleyer, Louis Schuster, Matthias Englbrecht, Andreas Berlin, Camille P Figueiredo, David Simon, Christian Muschitz, Roland Kocijan, Heinrich Resch, Jürgen Rech, Georg Schett
BACKGROUND: In the present study, we investigated bone geometry, microstructure, and volumetric bone mineral density (vBMD) in a cohort of patients with nonradiographic axial spondyloarthritis (nr-axSpA) in order to define the early bone changes occurring in axial spondyloarthritis (axSpA) and to define potential factors for deterioration of bone microstructure. METHODS: Patients with axSpA (n = 107) and healthy control subjects (n = 50) of similar age and sex were assessed for geometric, volumetric, and microstructural parameters of bone using high-resolution peripheral quantitative computed tomography (HR-pQCT) at the radius...
August 30, 2018: Arthritis Research & Therapy
Ji-Yih Chen, Chin-Man Wang, Tai-Di Chen, Yeong-Jian Jan Wu, Jing-Chi Lin, Ling Ying Lu, Jianming Wu
BACKGROUND: Type III interferons (IFNs) or IFN-λs are the newly discovered cytokines that primarily target the cells of epithelial and myeloid lineages, which are major components of kidneys. The current study aimed to investigate whether IFN-λs are involved in the pathogenesis of systemic lupus erythematosus (SLE) and lupus nephritis. METHODS: TaqMan allele discrimination assays were used to determine IFNL3/4 SNP genotypes of 1620 healthy controls and 1013 SLE patients (two independent cohorts consisting of 831 and 182 subjects, respectively) from Taiwan...
August 29, 2018: Arthritis Research & Therapy
Ursula Schulte-Wrede, Till Sörensen, Joachim R Grün, Thomas Häupl, Heike Hirseland, Marta Steinbrich-Zöllner, Peihua Wu, Andreas Radbruch, Denis Poddubnyy, Joachim Sieper, Uta Syrbe, Andreas Grützkau
BACKGROUND: Therapeutic targeting of tumour necrosis factor (TNF)-α is highly effective in ankylosing spondylitis (AS) patients. However, since one-third of anti-TNF-treated AS patients do not show an adequate clinical response there is an urgent need for new biomarkers that would aid clinicians in their decision-making to select appropriate therapeutic options. Thus, the aim of this explorative study was to identify cell-based biomarkers in peripheral blood that could be used for a pre-treatment stratification of AS patients...
August 29, 2018: Arthritis Research & Therapy
Fackson Mwale, Koichi Masuda, Michael P Grant, Laura M Epure, Kenji Kato, Shingo Miyazaki, Kevin Cheng, Junichi Yamada, Won C Bae, Carol Muehleman, Peter J Roughley, John Antoniou
BACKGROUND: The degeneration of the intervertebral disc (IVD) is characterized by proteolytic degradation of the extracellular matrix, and its repair requires the production of an extracellular matrix with a high proteoglycan-to-collagen ratio characteristic of a nucleus pulposus (NP)-like phenotype in vivo. At the moment, there is no medical treatment to reverse or even retard disc degeneration. The purpose of the present study was to determine if a low dose of short link N (sLN), a recently discovered fragment of the link N peptide, could behave in a manner similar to that of link N in restoring the proteoglycan content and proteoglycan-to-collagen ratio of the disc in a rabbit model of IVD degeneration, as an indication of its potential therapeutic benefit in reversing disc degeneration...
August 29, 2018: Arthritis Research & Therapy
Thuy Nhu Thai, Ghadeer K Dawwas
No abstract text is available yet for this article.
August 29, 2018: Arthritis Research & Therapy
Makiko Yashiro Furuya, Tomoyuki Asano, Yuya Sumichika, Shuzo Sato, Hiroko Kobayashi, Hiroshi Watanabe, Eiji Suzuki, Hideko Kozuru, Hiroshi Yatsuhashi, Tomohiro Koga, Hiromasa Ohira, Hideharu Sekine, Atsushi Kawakami, Kiyoshi Migita
BACKGROUND: Granulocyte-macrophage colony-stimulating factor (GM-CSF) has emerged as a crucial cytokine that activates myeloid cells to initiate tissue inflammation. However, the molecular actions of GM-CSF against innate immunity are still poorly characterized. Here, we investigated the in vitro effects of GM-CSF on the activation of human myeloid lineages, neutrophils, and the underlying intracellular signaling mechanism, including inflammasome activation. METHODS: Human neutrophils were stimulated with GM-CSF in the presence or absence of tofacitinib...
August 29, 2018: Arthritis Research & Therapy
Elena Raschi, Cecilia Beatrice Chighizola, Laura Cesana, Daniela Privitera, Francesca Ingegnoli, Claudio Mastaglio, Pier Luigi Meroni, Maria Orietta Borghi
BACKGROUND: In systemic sclerosis (SSc), autoantibodies provide the most accurate tool to predict the disease subset and pattern of organ involvement. Scleroderma autoantibodies target nucleic acids or DNA/RNA-binding proteins, thus SSc immune complexes (ICs) can embed nucleic acids. Our working hypothesis envisaged that ICs containing scleroderma-specific autoantibodies might elicit proinflammatory and profibrotic effects in skin fibroblasts. METHODS: Fibroblasts were isolated from skin biopsies obtained from healthy subjects and patients with diffuse cutaneous SSc (dcSSc)...
August 29, 2018: Arthritis Research & Therapy
Marwa Qadri, Gregory D Jay, Ling X Zhang, Wendy Wong, Anthony M Reginato, Changqi Sun, Tannin A Schmidt, Khaled A Elsaid
BACKGROUND: Gout is an inflammatory arthritis caused by monosodium urate monohydrate (MSU) crystals' joint deposition. MSU phagocytosis by resident macrophages is a key step in gout pathogenesis. MSU phagocytosis triggers nuclear factor kappa B (NFκB) activation and production of cytokines and chemokines. Proteoglycan-4 (PRG4) is a glycoprotein produced by synovial fibroblasts and exerts an anti-inflammatory effect in the joint mediated by its interaction with cell surface receptor CD44...
August 29, 2018: Arthritis Research & Therapy
Miranda Houtman, Louise Ekholm, Espen Hesselberg, Karine Chemin, Vivianne Malmström, Ann M Reed, Ingrid E Lundberg, Leonid Padyukov
BACKGROUND: Polymyositis (PM) and dermatomyositis (DM) are two distinct subgroups of idiopathic inflammatory myopathies, a chronic inflammatory disorder clinically characterized by muscle weakness and inflammatory cell infiltrates in muscle tissue. In PM, a major component of inflammatory cell infiltrates is CD8+ T cells, whereas in DM, CD4+ T cells, plasmacytoid dendritic cells, and B cells predominate. In this study, with the aim to differentiate involvement of CD4+ and CD8+ T-cell subpopulations in myositis subgroups, we investigated transcriptomic profiles of T cells from peripheral blood of patients with myositis...
August 29, 2018: Arthritis Research & Therapy
Qian Niu, Zhuo-Chun Huang, Xiao-Juan Wu, Ya-Xiong Jin, Yun-Fei An, Ya-Mei Li, Huan Xu, Bin Yang, Lan-Lan Wang
BACKGROUND: Follicular helper T (Tfh) cells are specialized in helping B lymphocytes, which play a central role in autoimmune diseases that have a major B cell component, such as in rheumatoid arthritis (RA). Follicular regulatory T (Tfr) cells control the over-activation of Tfh and B cells in germinal centers. Dysregulation of Tfh cells and Tfr cells has been reported to be involved in the pathogenesis of some autoimmune diseases. However, the balance of Tfh and Tfr cells, and their roles in the development and progression of RA are still not clear...
August 29, 2018: Arthritis Research & Therapy
Meliha C Kapetanovic, Peter Nilsson, Carl Turesson, Martin Englund, Nicola Dalbeth, Lennart Jacobsson
BACKGROUND: Hyperuricemia (HU) is in the causal pathway for developing clinical gout. There are few population-based assessments of the absolute and relative risk of clinically diagnosed incident gout in subjects with HU. We aimed to explore the long-term risk of developing incident gout among asymptomatic adults with different levels of serum urate (SU). METHODS: Malmö Preventive Project was a population-based screening program for cardiovascular risk factors, alcohol abuse, and breast cancer in Malmö, Sweden...
August 29, 2018: Arthritis Research & Therapy
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