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Reproductive Biology and Endocrinology: RB&E

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https://www.readbyqxmd.com/read/28623929/the-potential-regulatory-mechanisms-of-the-gonadotropin-releasing-hormone-in-gonadotropin-transcriptions-identified-with-bioinformatics-analyses
#1
Wei Xiang, Baoyun Zhang, Fenglin Lv, Guangde Feng, Long Chen, Fang Yang, Ke Zhang, Chunyu Cao, Pingqing Wang, Mingxing Chu
BACKGROUND: The regulation of gonadotropin synthesis and release by gonadotropin-releasing hormone (GnRH) plays an essential role in the neuroendocrine control of reproduction. However, the mechanisms underlying gonadotropin regulation by GnRH pulse frequency and amplitude are still ambiguous. This study aimed to explore the molecular mechanisms and biological pathways associated with gonadotropin synthesis by GnRH pulse frequencies and amplitudes. METHODS: Using GSE63251 datasets downloaded from the Gene Expression Omnibus (GEO), differentially expressed genes (DEGs) were screened by comparing the RNA expression from the GnRH pulse group, the GnRH tonic group and the control group...
June 17, 2017: Reproductive Biology and Endocrinology: RB&E
https://www.readbyqxmd.com/read/28606175/differences-in-utilization-of-intracytoplasmic-sperm-injection-icsi-within-human-services-hhs-regions-and-metropolitan-megaregions-in-the-u-s
#2
Pavel Zagadailov, Albert Hsu, David B Seifer, Judy E Stern
BACKGROUND: Anecdotal evidence suggests that US practice patterns for ART differ by geographical region. The purpose of this study was to determine whether use of ICSI differs by region and to evaluate whether these rates are correlated with differences in live birth rates. METHODS: Public data for 2012 were obtained from the Centers for Disease Control and Prevention. Clinics with ≥100 fresh, non-donor cycles were grouped by 10 nationally recognized Department of Health & Human Services regions and 11 metropolitan Megaregions and were compared for use of ICSI, frequency of male factor infertility, and live birth rate in women <35 years...
June 12, 2017: Reproductive Biology and Endocrinology: RB&E
https://www.readbyqxmd.com/read/28595591/effect-of-race-and-ethnicity-on-utilization-and-outcomes-of-assisted-reproductive-technology-in-the-usa
#3
Alice J Shapiro, Sarah K Darmon, David H Barad, David F Albertini, Norbert Gleicher, Vitaly A Kushnir
BACKGROUND: The purpose of this study was to determine the utilization and live birth rates of assisted reproductive technology (ART) modalities among various racial and ethnic groups in recent years. METHODS: We reviewed ART data reported to the Society for Assisted Reproductive Technologies Clinic Outcome Reporting System (SART CORS) for autologous ART and third-party ART (3ART) cycles which involved donor oocytes, sperm, embryos and gestational carrier, performed in the U...
June 8, 2017: Reproductive Biology and Endocrinology: RB&E
https://www.readbyqxmd.com/read/28577574/activating-transcription-factor-3-promotes-embryo-attachment-via-up-regulation-of-leukemia-inhibitory-factor-in-vitro
#4
Xi Cheng, Jingyu Liu, Huizhi Shan, Lihua Sun, Chenyang Huang, Qiang Yan, Ruiwei Jiang, Lijun Ding, Yue Jiang, Jianjun Zhou, Guijun Yan, Haixiang Sun
BACKGROUND: A receptive endometrium is essential for maternal-embryonic molecular communication during implantation. However, the specific molecular regulatory mechanisms of the endometrial capacity remain poorly understood. Here, we examined activating transcription factor 3 (ATF3) expression in human endometria and the functional effect of ATF3 on embryo attachment in vitro. METHODS: Immunohistochemistry (IHC) was used to assess the ATF3 expression patterns in human endometria...
June 2, 2017: Reproductive Biology and Endocrinology: RB&E
https://www.readbyqxmd.com/read/28576120/expression-of-genes-associated-with-bmp-signaling-pathway-in-porcine-oocytes-before-and-after-ivm-a-microarray-approach
#5
Joanna Budna, Marta Rybska, Sylwia Ciesiółka, Artur Bryja, Sylwia Borys, Wiesława Kranc, Katarzyna Wojtanowicz-Markiewicz, Michal Jeseta, Ewa Sumelka, Dorota Bukowska, Paweł Antosik, Klaus P Brüssow, Małgorzata Bruska, Michał Nowicki, Maciej Zabel, Bartosz Kempisty
BACKGROUND: The full maturational capability of mammalian oocytes is accompanied by nuclear and cytoplasmic modifications, which are associated with proliferation and differentiation of surrounding cumulus cells. These events are regulated on molecular level by the expression of target genes involved in signal transduction pathways crucial for folliculogenesis and oogenesis. Transforming growth factor beta signaling includes several molecules that are involved in the regulation of oogenesis and embryo growth, including bone morphogenetic protein (BMP)...
June 2, 2017: Reproductive Biology and Endocrinology: RB&E
https://www.readbyqxmd.com/read/28558842/natriuretic-peptides-improve-the-developmental-competence-of-in-vitro-cultured-porcine-oocytes
#6
Yanhao Zhang, Huarong Wang, Wei Liu, Ye Yang, Xiao Wang, Zhiyuan Zhang, Qirui Guo, Chao Wang, Guoliang Xia
BACKGROUND: Natriuretic peptides (NPs), brain and C type NPs (BNP and CNP), were involved in the maintenance of porcine oocyte meiotic arrest. The present study investigated the effects of NPs on developmental competence of immature porcine oocytes with follicles of different sizes. METHODS: Follicular fluid NP levels were examined by radioimmunoassay. The developmental competence of porcine oocytes was evaluated by cleavage and blastocyst developmental rates after in vitro fertilization (IVF) or parthenogenetic activation (PA) of cumulus oocyte complexes (COCs), which were recovered from follicle with different sizes...
May 30, 2017: Reproductive Biology and Endocrinology: RB&E
https://www.readbyqxmd.com/read/28549437/p-p-ddt-induces-testicular-oxidative-stress-induced-apoptosis-in-adult-rats
#7
Neila Marouani, Dorsaf Hallegue, Mohsen Sakly, Moncef Benkhalifa, Khémais Ben Rhouma, Olfa Tebourbi
BACKGROUND: The 1,1,1-trichloro-2,2-bis(4-chlorophenyl)ethane (p,p'-DDT) is a known persistent organic pollutant and male reproductive toxicant. The present study is designed to test the hypothesis that oxidative stress mediates p,p'-DDT-induced apoptosis in testis. METHODS: Male Wistar rats received an intraperitoneal (ip) injection of the pesticide at doses of 50 and 100mg/kg for 10 consecutive days. The oxidative stress was evaluated by biomarkers such lipid peroxidation (LPO) and metallothioneins (MTs) levels...
May 26, 2017: Reproductive Biology and Endocrinology: RB&E
https://www.readbyqxmd.com/read/28545515/outcome-of-in-vitro-fertilization-in-women-with-subclinical-hypothyroidism
#8
YunYing Cai, LanPing Zhong, Jie Guan, RuiJin Guo, Ben Niu, YanPing Ma, Heng Su
BACKGROUND: Previous studies examining associations between subclinical hypothyroidism (SCH) with in vitro fertilization (IVF) outcome indicate some benefits of levothyroxine (LT4) treatment. But IVF outcomes in treated SCH women whose serum Thyroid Stimulating Hormone (TSH) concentration did and did not exceed 2.5 mIU/L before the IVF cycle has not been studied thoroughly. METHODS: In this study, we performed a prospective cohort study with 270 treated subclinical hypothyroidism patients undergoing their first IVF retrieval cycle at a single cite...
May 25, 2017: Reproductive Biology and Endocrinology: RB&E
https://www.readbyqxmd.com/read/28499456/role-of-micrornas-in-premature-ovarian-insufficiency
#9
REVIEW
Ying Guo, Junyan Sun, Dongmei Lai
Premature ovarian insufficiency (POI) is a typical disorder of amenorrhea lasting for a minimum of 4 months. The typical characteristics comprised of declined estrogen and raised serum concentrations of follicle-stimulating hormone (FSH) in women <40-year-old, primarily originating from iatrogenic factors, karyotypic abnormalities, and genetic factors. However, the etiology of POI remains unknown in approximately 90% of cases. POI could lead to infertility, osteoporosis, cardiovascular disorder, and cognitive dysfunction...
May 12, 2017: Reproductive Biology and Endocrinology: RB&E
https://www.readbyqxmd.com/read/28482910/pregnancy-rates-of-day-4-and-day-5-embryos-after-culture-in-an-integrated-time-lapse-incubator
#10
Verena Holschbach, Julia Weigert, Jens Erik Dietrich, Sabine Roesner, Markus Montag, Thomas Strowitzki, Bettina Toth
BACKGROUND: The aim of this study was to compare pregnancy rates in patients undergoing IVF/ICSI with embryo transfer after 4 and 5 days of culture in a closed incubation system with integrated time-lapse imaging. METHODS: Out of n = 2207 in vitro fertilization (IVF)/ intracytoplasmic sperm injection (ICSI) cycles performed between January 2011 and April 2016 at a tertiary referral university hospital, a total of n = 599 IVF/ICSI cycles with prolonged embryo culture in an integrated time-lapse system (EmbryoScope(©) (Vitrolife)) until day 4 or 5 were retrospectively analyzed with regard to embryo morphology and pregnancy rates...
May 8, 2017: Reproductive Biology and Endocrinology: RB&E
https://www.readbyqxmd.com/read/28472983/comparative-neonatal-outcomes-in-singleton-births-from-blastocyst-transfers-or-cleavage-stage-embryo-transfers-a-systematic-review-and-meta-analysis
#11
REVIEW
Xingling Wang, Mingze Du, Yichun Guan, Bijun Wang, Junwei Zhang, Zihua Liu
BACKGROUND: Comparative neonatal outcomes with respect to singleton births from blastocyst transfers or cleavage-state embryo transfers are controversial with respect to which method is superior. Many studies have yielded contradictory results. We performed a systematic review and meta-analysis for the purpose of comparing neonatal outcomes in single births following IVF/ICSI. METHODS: We searched the Medline, Embase and Cochrane Central Register of Clinical Trials (CCTR) databases until October 2016...
May 4, 2017: Reproductive Biology and Endocrinology: RB&E
https://www.readbyqxmd.com/read/28464910/intracerebroventricular-injection-of-rfrp-3-delays-puberty-onset-and-stimulates-growth-hormone-secretion-in-female-rats
#12
Xinghui Han, Yuanyuan He, Gulan Zeng, Yonghong Wang, Wen Sun, Junchao Liu, Yanyan Sun, Jian Yu
BACKGROUND: Puberty onset is a complex, organized biological process with multilevel regulation, and its physiopathological mechanisms are yet to be elucidated. RFRP-3, the mammalian ortholog to gonadotropin-inhibitory hormone, is implicated in inhibiting the synthesis and release of gonadotropin in mammals. However, it is unclear whether RFRP-3 participates in regulating pubertal development. METHODS: This study investigated the functional significance and regulatory mechanism of hypothalamic RFRP-3 neuropeptide in the onset of puberty in young female rats...
May 2, 2017: Reproductive Biology and Endocrinology: RB&E
https://www.readbyqxmd.com/read/28454580/association-of-skewed-x-chromosome-inactivation-with-fmr1-cgg-repeat-length-and-anti-mullerian-hormone-levels-a-cohort-study
#13
David H Barad, Sarah Darmon, Andrea Weghofer, Gary J Latham, Filipovic-Sadic, Qi Wang, Vitaly A Kushnir, David F Albertini, Norbert Gleicher
BACKGROUND: Premutation range CGGn repeats of the FMR1 gene denote risk toward primary ovarian insufficiency (POI), also called premature ovarian failure (POF). This prospective cohort study was undertaken to determine if X-chromosome inactivation skew (sXCI) is associated with variations in FMR1 CGG repeat length and, if so, is also associated with age adjusted antimüllerian hormone (AMH) levels as an indicator of functional ovarian reserve (FOR). METHODS: DNA samples of 58 women were analyzed for methylation status and confirmation of CGGn repeat length...
April 28, 2017: Reproductive Biology and Endocrinology: RB&E
https://www.readbyqxmd.com/read/28449669/a-single-trophectoderm-biopsy-at-blastocyst-stage-is-mathematically-unable-to-determine-embryo-ploidy-accurately-enough-for-clinical-use
#14
Norbert Gleicher, Jacob Metzger, Gist Croft, Vitaly A Kushnir, David F Albertini, David H Barad
BACKGROUND: It has become increasingly apparent that the trophectoderm (TE) at blastocyst stage is much more mosaic than has been appreciated. Whether preimplantation genetic screening (PGS), utilizing a single TE biopsy (TEB), can reliably determine embryo ploidy has, therefore, increasingly been questioned in parallel. METHODS: We for that reason here established 2 mathematical models to assess probabilities of false-negative and false-positive results of an on average 6-cell biopsy from an approximately 300-cell TE...
April 27, 2017: Reproductive Biology and Endocrinology: RB&E
https://www.readbyqxmd.com/read/28446183/effect-of-different-artificial-shrinkage-methods-when-applied-before-blastocyst-vitrification-on-perinatal-outcomes
#15
Caizhu Wang, Guixue Feng, Bo Zhang, Hong Zhou, Jinhui Shu, Ruoyun Lin, Huanhua Chen, Zhulian Wu
BACKGROUND: In recent years, single blastocyst transfer combined with vitrification has been applied widely, which can maximize the cumulative pregnancy rate in per oocyte retrieval cycles and minimize the multiple pregnancy rate. Thus, the guarantee for these is the effectiveness of vitrified blastocyst. Studies has shown that AS of the blastocoel cavity prior to vitrification can reduce injuries, increase the thawed blastocyst survival rate and implantation rate. Several AS methods have been established...
April 26, 2017: Reproductive Biology and Endocrinology: RB&E
https://www.readbyqxmd.com/read/28446182/improving-preimplantation-genetic-diagnosis-pgd-reliability-by-selection-of-sperm-donor-with-the-most-informative-haplotype
#16
Mira Malcov, Veronica Gold, Sagit Peleg, Tsvia Frumkin, Foad Azem, Ami Amit, Dalit Ben-Yosef, Yuval Yaron, Adi Reches, Shimi Barda, Sandra E Kleiman, Leah Yogev, Ron Hauser
BACKGROUND: The study is aimed to describe a novel strategy that increases the accuracy and reliability of PGD in patients using sperm donation by pre-selecting the donor whose haplotype does not overlap the carrier's one. METHODS: A panel of 4-9 informative polymorphic markers, flanking the mutation in carriers of autosomal dominant/X-linked disorders, was tested in DNA of sperm donors before PGD. Whenever the lengths of donors' repeats overlapped those of the women, additional donors' DNA samples were analyzed...
April 26, 2017: Reproductive Biology and Endocrinology: RB&E
https://www.readbyqxmd.com/read/28438181/efficient-vitrification-of-mouse-embryos-using-the-kitasato-vitrification-system-as-a-novel-vitrification-device
#17
Kenji Momozawa, Atsushi Matsuzawa, Yukio Tokunaga, Shiori Abe, Yumi Koyanagi, Miho Kurita, Marina Nakano, Takao Miyake
BACKGROUND: Currently, the cryopreservation of embryos and oocytes is essential for assisted reproductive technology (ART) laboratories worldwide. This study aimed to evaluate the efficacy of the Kitasato Vitrification System (KVS) as a vitrification device for the cryopreservation of mouse embryos to determine whether this novel device can be adapted to the field of ART. METHODS: In Experiment 1, blastocysts were vitrified using the KVS. Vitrified blastocysts were warmed and subsequently cultured for 72 h...
April 24, 2017: Reproductive Biology and Endocrinology: RB&E
https://www.readbyqxmd.com/read/28438170/immunolocalization-of-steroidogenic-enzymes-in-the-vaginal-mucous-of-galea-spixii-during-the-estrous-cycle
#18
Amilton Cesar Dos Santos, Alan James Conley, Moacir Franco de Oliveira, Gleidson Benevides Oliveira, Diego Carvalho Viana, Antônio Chaves de Assis Neto
BACKGROUND: The synthesis of sex steroids is controlled by several enzymes such as17α-hydroxylase cytochrome P450 (P450c17) catalyzing androgen synthesis and aromatase cytochrome P450 (P450arom) catalyzing estrogen synthesis, both of which must complex with the redox partner NADPH-cytochrome P450 oxidoreductase (CPR) for activity. Previous studies have identified expression of steroidogenic enzymes in vaginal tissue, suggesting local sex steroid synthesis. The current studies investigate P450c17, P450aromatase and CPR expression in vaginal mucosa of Galea spixii (Spix cavy) by immuno-histochemical and western immunoblot analyses...
April 24, 2017: Reproductive Biology and Endocrinology: RB&E
https://www.readbyqxmd.com/read/28427432/anti-human-platelet-antigen-hpa-1a-antibodies-may-affect-trophoblast-functions-crucial-for-placental-development-a-laboratory-study-using-an-in-vitro-model
#19
Mariana Eksteen, Gøril Heide, Heidi Tiller, Yan Zhou, Nora Hersoug Nedberg, Inigo Martinez-Zubiaurre, Anne Husebekk, Bjørn R Skogen, Tor B Stuge, Mette Kjær
BACKGROUND: Fetal and neonatal alloimmune thrombocytopenia (FNAIT) is a bleeding disorder caused by maternal antibodies against paternal human platelet antigens (HPAs) on fetal platelets. Antibodies against HPA-1a are accountable for the majority of FNAIT cases. We have previously shown that high levels of maternal anti-HPA-1a antibodies are associated with clinically significant reduced birth weight in newborn boys. Chronic inflammatory placental lesions are associated with increased risk of reduced birth weight and have previously been reported in connection with FNAIT pregnancies...
April 21, 2017: Reproductive Biology and Endocrinology: RB&E
https://www.readbyqxmd.com/read/28395662/erratum-to-comment-on-gleicher-n-et-al-2016-reprod-biol-endocrinol-sep-5-14-1-54
#20
Ashley W Tiegs, James A Grifo, Santiago Munné, David H McCulloh, Brooke Hodes-Wertz
No abstract text is available yet for this article.
April 10, 2017: Reproductive Biology and Endocrinology: RB&E
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