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Reproductive Biology and Endocrinology: RB&E

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https://www.readbyqxmd.com/read/28077131/granulocyte-colony-stimulating-factor-g-csf-promotes-spermatogenic-regeneration-from-surviving-spermatogonia-after-high-dose-alkylating-chemotherapy
#1
Travis Kotzur, Roberto Benavides-Garcia, Jennifer Mecklenburg, Jamila R Sanchez, Matthew Reilly, Brian P Hermann
BACKGROUND: The lifesaving chemotherapy and radiation treatments that allow patients to survive cancer can also result in a lifetime of side-effects, including male infertility. Infertility in male cancer survivors is thought to primarily result from killing of the spermatogonial stem cells (SSCs) responsible for producing spermatozoa since SSCs turn over slowly and are thereby sensitive to antineoplastic therapies. We previously demonstrated that the cytokine granulocyte colony-stimulating factor (G-CSF) can preserve spermatogenesis after alkylating chemotherapy (busulfan)...
January 11, 2017: Reproductive Biology and Endocrinology: RB&E
https://www.readbyqxmd.com/read/28069012/systematic-review-of-worldwide-trends-in-assisted-reproductive-technology-2004-2013
#2
REVIEW
Vitaly A Kushnir, David H Barad, David F Albertini, Sarah K Darmon, Norbert Gleicher
BACKGROUND: Assisted Reproductive Technology (ART) has undergone considerable changes over the last decade, with consequences on ART outcomes in different regions of the world being unknown. METHODS: We conducted a systematic review of published national and regional ART registry data to assess how changes in clinical practice between 2004 and 2013 have impacted outcomes in Australia and New Zealand, Canada, Continental Europe, the United Kingdom (U.K.), Japan, Latin America, and the United States (U...
January 10, 2017: Reproductive Biology and Endocrinology: RB&E
https://www.readbyqxmd.com/read/28056997/human-lh-and-hcg-stimulate-differently-the-early-signalling-pathways-but-result-in-equal-testosterone-synthesis-in-mouse-leydig-cells-in-vitro
#3
Laura Riccetti, Francesco De Pascali, Lisa Gilioli, Francesco Potì, Lavinia Beatrice Giva, Marco Marino, Simonetta Tagliavini, Tommaso Trenti, Flaminia Fanelli, Marco Mezzullo, Uberto Pagotto, Manuela Simoni, Livio Casarini
BACKGROUND: Human luteinizing hormone (LH) and chorionic gonadotropin (hCG) are glycoprotein hormones regulating development and reproductive functions by acting on the same receptor (LHCGR). We compared the LH and hCG activity in gonadal cells from male mouse in vitro, i.e. primary Leydig cells, which is a common tool used for gonadotropin bioassay. Murine Leydig cells are naturally expressing the murine LH receptor (mLhr), which binds human LH/hCG. METHODS: Cultured Leydig cells were treated by increasing doses of recombinant LH and hCG, and cell signaling, gene expression and steroid synthesis were evaluated...
January 5, 2017: Reproductive Biology and Endocrinology: RB&E
https://www.readbyqxmd.com/read/28056994/hexokinase-2-drives-glycogen-accumulation-in-equine-endometrium-at-day-12-of-diestrus-and-pregnancy
#4
Sarah A Bramer, Alysson Macedo, Claudia Klein
BACKGROUND: Secretion of histotroph during the prolonged pre-implantation phase in mares is crucial to pregnancy maintenance, manifested as increased embryonic loss in mares with age-related endometrial degeneration. Glycogen content of uterine histotroph is higher during the progesterone-dominated phase of the estrous cycle in mares, but regulatory mechanisms are not well understood. METHODS: mRNA expression of glycogen-metabolizing enzymes (HK1, HK2, GSK3B, GYS1, PEPCK, PKM, PYGM) in endometrial samples were compared among mares in anestrus, estrus, and at Day 12 of diestrus and pregnancy...
January 5, 2017: Reproductive Biology and Endocrinology: RB&E
https://www.readbyqxmd.com/read/28056989/induction-of-altered-gene-expression-profiles-in-cultured-bovine-granulosa-cells-at-high-cell-density
#5
Anja Baufeld, Dirk Koczan, Jens Vanselow
BACKGROUND: In previous studies it has been shown that bovine granulosa cells (GC) cultured at a high plating density dramatically change their physiological and molecular characteristics, thus resembling an early stage of luteinization. During the present study, these specific effects on the GC transcriptome were comprehensively analysed to clarify the underlying mechanisms. METHODS: GC were cultured in serum free medium with FSH and IGF-1 stimulation at different initial plating density...
January 5, 2017: Reproductive Biology and Endocrinology: RB&E
https://www.readbyqxmd.com/read/28056983/influence-of-endometrial-thickness-on-treatment-outcomes-following-in-vitro-fertilization-intracytoplasmic-sperm-injection
#6
Ning-Zhao Ma, Lei Chen, Wei Dai, Zhi-Qin Bu, Lin-Li Hu, Ying-Pu Sun
BACKGROUND: The study was designed to investigate the roles of endometrial thickness (EMT) at the day of human chorionic gonadotropin (hCG) administration on pregnancy outcomes in a large patient population. METHODS: This retrospective cohort study included 9,952 patients undergoing their first IVF/ICSI with autologous oocytes from January 2011 to January 2015. Patients were divided into three groups based on the EMT (group A:≤8 mm; group B: 9-14 mm and group C:≥15 mm)...
January 5, 2017: Reproductive Biology and Endocrinology: RB&E
https://www.readbyqxmd.com/read/28049501/the-abnormal-expression-of-oxytocin-receptors-in-the-uterine-junctional-zone-in-women-with-endometriosis
#7
Miaomaio Huang, Xuqing Li, Peipei Guo, Zhaojuan Yu, Yuting Xu, Zhaolian Wei
BACKGROUND: The junctional zone (JZ), also called as the endometrial-myometrial junction, is related to peristaltic-like movements in the non-pregnant uterus. Hyperperistalsis and dysperistalsis of uterus constructions might underlie many important disorders such as dysmenorrhea, infertility, endometriosis, implantation failure. The major proteins for uterine contraction of the non-pregnant uterus may be Oxytocin (OT) and oxytocin receptor (OTR). The objective of this study was to inspect the expression of OTR in isthmic and mid-fundal parts of the uterine junctional zone at different stages of the follicular cycle in patients with and without endometriosis...
January 3, 2017: Reproductive Biology and Endocrinology: RB&E
https://www.readbyqxmd.com/read/27938385/comparison-of-the-effect-of-a-combination-of-eight-micronutrients-versus-a-standard-mono-preparation-on-sperm-parameters
#8
Markus Lipovac, Florian Bodner, Martin Imhof, Peter Chedraui
BACKGROUND: There are reports showing that l-carnitine alone or in combination with other micronutrients improve sperm parameters. However, comparative studies are still lacking. This study was carried out to compare the short term effects of a combination of eight micronutrients including l-carnitine vs. a mono-substance (l-carnitine alone) on sperm parameters. METHODS: This was a prospective, open-labelled, nonrandomized study that included male subjects (20 to 60 years) with at least 1 year of subfertility and at least one pathological semen analysis who received 3 months treatment with a mono-substance (500 mg l-carnitine/twice a day, n = 156) or a combined compound (440 mg l-carnitine + 250 mg l-arginine + 40 mg zinc + 120 mg vitamin E + 80 mg glutathione + 60 μg selenium + 15 mg coenzyme Q10 + 800 μg folic acid/once a day, n = 143) for the same time period...
December 9, 2016: Reproductive Biology and Endocrinology: RB&E
https://www.readbyqxmd.com/read/27919288/variation-in-male-spermiation-response-to-exogenous-hormones-among-divergent-populations-of-red-eyed-treefrogs
#9
Leah E Jacobs, Jeanne M Robertson, Kristine Kaiser
BACKGROUND: The non-lethal collection of sperm from live males is an important component for multiple captive-breeding techniques, including assisted reproductive technology (ART) protocols, sperm cryopreservation and in vitro fertilization. However, in amphibians, the type and amount of hormone necessary to induce spermiation can be highly variable, even among closely related species. We are unaware of any studies that have examined the spermiation response to exogenous hormones across highly differentiated populations within a species...
December 5, 2016: Reproductive Biology and Endocrinology: RB&E
https://www.readbyqxmd.com/read/27919266/arrest-at-the-diplotene-stage-of-meiotic-prophase-i-is-delayed-by-progesterone-but-is-not-required-for-primordial-follicle-formation-in-mice
#10
Sudipta Dutta, Deion M Burks, Melissa E Pepling
BACKGROUND: In mammalian females, reproductive capacity is determined by the size of the primordial follicle pool. During embryogenesis, oogonia divide mitotically but cytokinesis is incomplete so oogonia remain connected in germ cell cysts. Oogonia begin to enter meiosis at 13.5 days postcoitum in the mouse and over several days, oocytes progress through the stages of meiotic prophase I arresting in the diplotene stage. Concurrently, germ cell cysts break apart and individual oocytes become surrounded by granulosa cells forming primordial follicles...
December 5, 2016: Reproductive Biology and Endocrinology: RB&E
https://www.readbyqxmd.com/read/27881125/enhanced-expression-of-the-stemness-related-factors-oct4-sox15-and-twist1-in-ectopic-endometrium-of-endometriosis-patients
#11
Katharina Proestling, Peter Birner, Sukirthini Balendran, Nadine Nirtl, Erika Marton, Gülen Yerlikaya, Lorenz Kuessel, Theresa Reischer, Rene Wenzl, Berthold Streubel, Heinrich Husslein
BACKGROUND: Current evidence suggests that endometrial-derived stem cells, spilled in the peritoneal cavity via retrograde menstruation, are key players in the establishment of endometriotic lesions. The aim of this study was to determine the presence and distribution of the stemness-related factors OCT4, SOX15, TWIST1 and DCAMLK1 in women with and without endometriosis. METHODS: Immunohistochemical analysis was used to determine stromal and epithelial expression of OCT4, SOX15, TWIST1 and DCAMLK1 in endometriosis patient (EP) endometrium (n = 69) and endometriotic tissue (n = 90) and in control endometrium (n = 50)...
November 24, 2016: Reproductive Biology and Endocrinology: RB&E
https://www.readbyqxmd.com/read/27842549/acth-induced-stress-in-weaned-sows-impairs-lh-receptor-expression-and-steroidogenesis-capacity-in-the-ovary
#12
H S Zhu, Z Qian, H L Liu, E D Bao
BACKGROUND: Stress has been proved to impair the porcine reproduction soundly. Endocrine disruption, which is closely related to the persistent follicles, is possibly one of the results of stress, although the mechanism is unclear. Since the expression of luteinizing hormone receptor (LHR) in ovarian follicular wall and concentrations of steroid hormone in follicular fluid are related to the development of persistent follicles, this study is designed to evaluate the effect of administered adrenocorticotrophic hormone (ACTH) to weaned pigs on their ovarian steroidogenesis capacity and LHR expression...
November 14, 2016: Reproductive Biology and Endocrinology: RB&E
https://www.readbyqxmd.com/read/27832793/cryopreservation-and-xenografting-of-human-ovarian-fragments-medulla-decreases-the-phosphatidylserine-translocation-rate
#13
Vladimir Isachenko, Plamen Todorov, Evgenia Isachenko, Gohar Rahimi, Bettina Hanstein, Mahmoud Salama, Peter Mallmann, Andrey Tchorbanov, Paul Hardiman, Natalie Getreu, Markus Merzenich
BACKGROUND: Phosphatidylserine is the phospholipid component which plays a key role in cell cycle signaling, specifically in regards to necrosis and apoptosis. When a cell affected by some negative factors, phosphatidylserine is no longer restricted to the intracellular side of membrane and can be translocated to the extracellular surface of the cell. Cryopreservation can induce translocation of phosphatidylserine in response to hypoxia, increasing intracellular Ca(2+), osmotic disruption of cellular membranes, generation of reactive oxygen species and lipid peroxidation...
November 10, 2016: Reproductive Biology and Endocrinology: RB&E
https://www.readbyqxmd.com/read/27829441/characterization-of-exosomal-release-in-bovine-endometrial-intercaruncular-stromal-cells
#14
Yong Qin Koh, Hassendrini N Peiris, Kanchan Vaswani, Sarah Reed, Gregory E Rice, Carlos Salomon, Murray D Mitchell
BACKGROUND: Cell-to-cell communication between the blastocyst and endometrium is critical for implantation. In recent years, evidence has emerged from studies in humans and several other animal species that exosomes are secreted from the endometrium and trophoblast cells and may play an important role in cell-to-cell communication maternal-fetal interface during early pregnancy. Exosomes are stable extracellular lipid bilayer vesicles that encapsulate proteins, miRNAs, and mRNAs, with the ability to deliver their cargo to near and distant sites, altering cellular function(s)...
November 9, 2016: Reproductive Biology and Endocrinology: RB&E
https://www.readbyqxmd.com/read/27821126/efficient-generation-of-ggta1-null-diannan-miniature-pigs-using-talens-combined-with-somatic-cell-nuclear-transfer
#15
Wenmin Cheng, Heng Zhao, Honghao Yu, Jige Xin, Jia Wang, Luyao Zeng, Zaimei Yuan, Yubo Qing, Honghui Li, Baoyu Jia, Cejun Yang, Youfeng Shen, Lu Zhao, Weirong Pan, Hong-Ye Zhao, Wei Wang, Hong-Jiang Wei
BACKGROUND: α1,3-Galactosyltransferase (GGTA1) is essential for the biosynthesis of glycoproteins and therefore a simple and effective target for disrupting the expression of galactose α-1,3-galactose epitopes, which mediate hyperacute rejection (HAR) in xenotransplantation. Miniature pigs are considered to have the greatest potential as xenotransplantation donors. A GGTA1-knockout (GTKO) miniature pig might mitigate or prevent HAR in xenotransplantation. METHODS: Transcription activator-like effector nucleases (TALENs) were designed to target exon 6 of porcine GGTA1 gene...
November 8, 2016: Reproductive Biology and Endocrinology: RB&E
https://www.readbyqxmd.com/read/27814762/risk-of-adverse-pregnancy-and-perinatal-outcomes-after-high-technology-infertility-treatment-a-comprehensive-systematic-review
#16
REVIEW
Stefano Palomba, Roy Homburg, Susanna Santagni, Giovanni Battista La Sala, Raoul Orvieto
In the literature, there is growing evidence that subfertile patients who conceived after infertility treatments have an increased risk of pregnancy and perinatal complications and this is particularly true for patients who conceived through use of high technology infertility treatments. Moreover, high technology infertility treatments include many concomitant clinical and biological risk factors. This review aims to summarize in a systematic fashion the current evidence regarding the relative effect of the different procedures for high technology infertility treatments on the risk of adverse pregnancy and perinatal outcome...
November 4, 2016: Reproductive Biology and Endocrinology: RB&E
https://www.readbyqxmd.com/read/27809846/the-participation-of-the-muscarinic-receptors-in-the-preoptic-anterior-hypothalamic-areas-in-the-regulation-of-ovulation-depends-on-the-ovary
#17
Adriana Espinosa-Valdez, Angélica Flores, Isabel Arrieta-Cruz, Mario Cárdenas, Roberto Chavira, Roberto Domínguez, María Esther Cruz
BACKGROUND: Muscarinic receptors (mAChRs) of the preoptic and anterior hypothalamus areas (POA-AHA) regulate ovulation in an asymmetric manner during the estrous cycle. The aims of the present study were to analyze the effects of a temporal blockade of mAChRs on either side of the POA-AHA performed in diestrus-2 rats on ovulation, the levels of estradiol, follicle stimulating hormone (FSH) and luteinizing hormone (LH) and the mechanisms involved in changes in ovulation. METHODS: Cyclic rats on diestrus-2 day were anesthetized and randomly assigned to the following groups: 1) microinjection of 1 μl of saline or atropine solution (62...
November 4, 2016: Reproductive Biology and Endocrinology: RB&E
https://www.readbyqxmd.com/read/27809920/assisted-reproductive-technology-pregnancy-complications-are-significantly-associated-with-endometriosis-severity-before-conception-a-retrospective-cohort-study
#18
Tatsuya Fujii, Osamu Wada-Hiraike, Takeshi Nagamatsu, Miyuki Harada, Tetsuya Hirata, Kaori Koga, Tomoyuki Fujii, Yutaka Osuga
BACKGROUND: Endometriosis has been shown to be associated with second- to third-trimester pregnancy complications such as preterm birth and placenta previa, but the evidence is inconsistent. We hypothesized that endometriosis severity might affect these inconsistent results. Therefore we aimed to conduct a retrospective cohort study to elucidate whether endometriosis severity is associated with the incidence rates of adverse pregnancy outcomes. METHODS: The patients who achieved singleton pregnancy by assisted reproductive technology (ART) in our facility between March 2000 and December 2014 (N = 631) were included in this analysis...
November 3, 2016: Reproductive Biology and Endocrinology: RB&E
https://www.readbyqxmd.com/read/27809915/biallelic-modification-of-il2rg-leads-to-severe-combined-immunodeficiency-in-pigs
#19
Jung-Taek Kang, Bumrae Cho, Junghyun Ryu, Caitlin Ray, Eun-Jin Lee, Yun-Jin Yun, SunMi Ahn, JinSeok Lee, Dal-Young Ji, Nathaniel Jue, Sherrie Clark-Deener, Kiho Lee, Kwang-Wook Park
BACKGROUND: Pigs with SCID can be a useful model in regenerative medicine, xenotransplantation, and cancer cell transplantation studies. Utilizing genome editing technologies such as CRISPR/Cas9 system allows us to generate genetically engineered pigs at a higher efficiency. In this study, we report generation and phenotypic characterization of IL2RG knockout female pigs produced through combination of CRISPR/Cas9 system and SCNT. As expected, pigs lacking IL2RG presented SCID phenotype...
November 3, 2016: Reproductive Biology and Endocrinology: RB&E
https://www.readbyqxmd.com/read/27793163/involvement-of-mesosalpinx-in-endometrioma-is-a-possible-risk-factor-for-decrease-of-ovarian-reserve-after-cystectomy-a-retrospective-cohort-study
#20
Ai Saito, Akira Iwase, Tomoko Nakamura, Satoko Osuka, Bayasula, Tomohiko Murase, Nao Kato, Chiharu Ishida, Sachiko Takikawa, Maki Goto, Fumitaka Kikkawa
BACKGROUND: Serum anti-Müllerian hormone (AMH) concentration has been used to assess ovarian reserve in patients with endometriosis, especially when endometrioma surgery is involved. Previously, we reported that decreased serum AMH levels after cystectomy for endometriomas can recover to preoperative levels in some cases. In this present study, we assessed the sequential changes in serum AMH levels before and after cystectomy in terms of the state of the mesosalpinx prior to surgery...
October 28, 2016: Reproductive Biology and Endocrinology: RB&E
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