Jinxin Miao, Rong Li, Arnaud J Van Wettere, Haoran Guo, Alexandru-Flaviu Tabaran, M Gerald O'Sullivan, Timothy Carlson, Patricia M Scott, Kuisheng Chen, Dongling Gao, Huixiang Li, Yaohe Wang, Zhongde Wang, Robert T Cormier
Background: The TP53 tumor suppressor gene is the most commonly mutated gene in human cancers. Humans who inherit mutant TP53 alleles develop a wide range of early onset cancers, a disorder called Li-Fraumeni Syndrome (LFS). Trp53 -deficient mice recapitulate most but not all of the cancer phenotypes observed in TP53 -deficient human cancers, indicating that new animal models may complement current mouse models and better inform on human disease development. Materials and Methods: The recent application of CRISPR/Cas9 genetic engineering technology has permitted the emergence of golden Syrian hamsters as genetic models for wide range of diseases, including cancer...
2021: Journal of Carcinogenesis