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Journal of Carcinogenesis

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https://www.readbyqxmd.com/read/27298590/the-well-accepted-notion-that-gene-amplification-contributes-to-increased-expression-still-remains-after-all-these-years-a-reasonable-but-unproven-assumption
#1
REVIEW
Yuping Jia, Lichan Chen, Qingwen Jia, Xixi Dou, Ningzhi Xu, Dezhong Joshua Liao
"Gene amplification causes overexpression" is a longstanding and well-accepted concept in cancer genetics. However, raking the whole literature, we find only statistical analyses showing a positive correlation between gene copy number and expression level, but do not find convincing experimental corroboration for this notion, for most of the amplified oncogenes in cancers. Since an association does not need to be an actual causal relation, in our opinion, this widespread notion still remains a reasonable but unproven assumption awaiting experimental verification...
2016: Journal of Carcinogenesis
https://www.readbyqxmd.com/read/27013929/antiangiogenic-mechanisms-and-factors-in-breast-cancer-treatment
#2
REVIEW
Jessica M Castañeda-Gill, Jamboor K Vishwanatha
Breast cancer is known to metastasize in its latter stages of existence. The different angiogenic mechanisms and factors that allow for its progression are reviewed in this article. Understanding these mechanisms and factors will allow researchers to design drugs to inhibit angiogenic behaviors and control the rate of tumor growth.
2016: Journal of Carcinogenesis
https://www.readbyqxmd.com/read/26900349/diagnostic-utility-of-serum-and-pleural-fluid-carcinoembryonic-antigen-and-cytokeratin-19-fragments-in-patients-with-effusion-from-nonsmall-cell-lung-cancer
#3
Sushil Kumar Sharma, Sanjay Bhat, Vikas Chandel, Mayank Sharma, Pulkit Sharma, Sakul Gupta, Sashank Sharma, Aijaz Ahmed Bhat
AIMS: To assess the diagnostic value of CEA and CYFRA 21-1 (cytokeratin 19 fragments) in serum and pleural fluid in non small cell lung cancer with malignant pleural effusion (MPE). SETTINGS AND DESIGN: Two subsets of patients were recruited with lymphocytic exudative effusion, one subset constituted diagnosed patients of NSCLC with malignant pleural effusion and the other subset of constituted with Tubercular pleural effusion. MATERIALS AND METHODS: CYFRA 21-1 and CEA levels were measured using Electrochemilumiscence Immunoassay (ECLIA)...
2015: Journal of Carcinogenesis
https://www.readbyqxmd.com/read/26435701/role-of-genomics-in-eliminating-health-disparities
#4
REVIEW
Meghana V Kashyap, Michael Nolan, Marc Sprouse, Ranajit Chakraborty, Deanna Cross, Rhonda Roby, Jamboor K Vishwanatha
The Texas Center for Health Disparities, a National Institute on Minority Health and Health Disparities Center of Excellence, presents an annual conference to discuss prevention, awareness education, and ongoing research about health disparities both in Texas and among the national population. The 2014 Annual Texas Conference on Health Disparities brought together experts in research, patient care, and community outreach on the "Role of Genomics in Eliminating Health Disparities." Rapid advances in genomics and pharmacogenomics are leading the field of medicine to use genetics and genetic risk to build personalized or individualized medicine strategies...
2015: Journal of Carcinogenesis
https://www.readbyqxmd.com/read/26085818/single-nucleotide-polymorphisms-in-crtc1-and-barx1-are-associated-with-esophageal-adenocarcinoma
#5
Anna M J van Nistelrooij, Hetty A G M van der Korput, Linda Broer, Ronald van Marion, Mark I van Berge Henegouwen, Carel J van Noesel, Katharina Biermann, Manon C W Spaander, Hugo W Tilanus, J Jan B van Lanschot, Albert Hofman, André G Uitterlinden, Bas P L Wijnhoven, Winand N M Dinjens
OBJECTIVE: Recently, single nucleotide polymorphisms (SNPs) associated with esophageal adenocarcinoma (EAC) and Barrett's esophagus (BE) were identified; rs10419226 (CRTC1), rs11789015 (BARX1), rs2687201 (FOXP1), rs2178146 (FOXF1), rs3111601 (FOXF1), and rs9936833 (FOXF1). These findings indicate that genetic susceptibility could play a role in the initiation of EAC in BE patients. The aim of this study was to validate the association between these previously identified SNPs and the risk of EAC in an independent and large case-control study...
2015: Journal of Carcinogenesis
https://www.readbyqxmd.com/read/26085817/molecular-pathways-to-therapeutics-paradigms-and-challenges-in-oncology-meeting-report-carcinogenesis-2015
#6
Ujjwala M Warawdekar, Pradnya Kowtal
The search for the most effective therapy with minimum side effects has always been the goal of oncologists and efforts to develop such therapies through understanding disease mechanisms has been the focus of many basic scientists in cancer research, leading to a common interest of convergence. The 5(th) International Conference organized by the Carcinogenesis Foundation, USA and Advanced Centre for Treatment, Research and Education in Cancer (ACTREC), Tata Memorial Centre, India, was held between February 11(th) and 13(th) 2015, at ACTREC...
2015: Journal of Carcinogenesis
https://www.readbyqxmd.com/read/25821410/pancreatic-cystic-neoplasms-review-of-current-knowledge-diagnostic-challenges-and-management-options
#7
REVIEW
Tanima Jana, Jennifer Shroff, Manoop S Bhutani
Pancreatic cystic lesions are being detected with increasing frequency, largely due to advances in cross-sectional imaging. The most common neoplasms include serous cystadenomas, mucinous cystic neoplasms, intraductal papillary mucinous neoplasms, solid pseudopapillary neoplasms, and cystic pancreatic endocrine neoplasms. Computed tomography (CT), magnetic resonance imaging (MRI), and endoscopic ultrasound (EUS) are currently used as imaging modalities. EUS-guided fine needle aspiration has proved to be a useful diagnostic tool, and enables an assessment of tumor markers, cytology, chemistries, and DNA analysis...
2015: Journal of Carcinogenesis
https://www.readbyqxmd.com/read/25788867/zoledronic-acid-directly-suppresses-cell-proliferation-and-induces-apoptosis-in-highly-tumorigenic-prostate-and-breast-cancers-retraction
#8
(no author information available yet)
[This retracts the article on p. 1 in vol. 10, PMID: 21297921.].
2015: Journal of Carcinogenesis
https://www.readbyqxmd.com/read/25788866/cancer-review-cholangiocarcinoma
#9
REVIEW
Yezaz Ahmed Ghouri, Idrees Mian, Boris Blechacz
Cholangiocarcinoma (CCA) is the most common biliary tract malignancy. CCA is classified as intrahepatic, perihilar or distal extrahepatic; the individual subtypes differ in their biologic behavior, clinical presentation, and management. Throughout the last decades, CCA incidence rates had significantly increased. In addition to known established risk factors, novel possible risk factors (i.e. obesity, hepatitis C virus) have been identified that are of high importance in developed countries where CCA prevalence rates have been low...
2015: Journal of Carcinogenesis
https://www.readbyqxmd.com/read/25589897/gastric-cancer-review
#10
REVIEW
Lauren Peirce Carcas
Gastric cancer is an aggressive disease that continues to have a daunting impact on global health. Despite an overall decline in incidence over the last several decades, gastric cancer remains the fourth most common type of cancer and is the second leading cause of cancer-related death worldwide. This review aims to discuss the global distribution of the disease and the trend of decreasing incidence of disease, delineate the different pathologic subtypes and their immunohistochemical (IHC) staining patterns and molecular signatures and mutations, explore the role of the pathogen H...
2014: Journal of Carcinogenesis
https://www.readbyqxmd.com/read/25525412/the-advent-of-precision-therapy-in-gastrointestinal-malignancies-targeting-the-human-epidermal-growth-factor-receptor-family-in-colorectal-and-esophagogastric-cancer
#11
REVIEW
Danielle Desautels, Craig Harlos, Piotr Czaykowski
Until recently, systemic therapy for gastrointestinal malignancies was restricted to relatively noncancer-specific cytotoxic chemotherapy. Over the last 15 years targeted therapies have become available, most notably bevacizumab in the case of advanced colorectal cancer. Unfortunately, there are no predictive biomarkers to guide the use of this agent. In this review article, we describe the advent of "Precision Medicine" (in part, the use of patient-specific molecular markers to inform treatment) in gastrointestinal cancers: The use of monoclonal antibodies targeting epidermal growth factor receptor in advanced colorectal cancer, and human epidermal growth factor receptor 2-neu in advanced esophagogastric cancer...
2014: Journal of Carcinogenesis
https://www.readbyqxmd.com/read/25506266/reducing-inequities-in-colorectal-cancer-screening-in-north-america
#12
REVIEW
Kathleen M Decker, Harminder Singh
Colorectal cancer (CRC) is an important cause of mortality and morbidity in North America. Screening using a fecal occult blood test, flexible sigmoidoscopy, or colonoscopy reduces CRC mortality through the detection and treatment of precancerous polyps and early stage CRC. Although CRC screening participation has increased in recent years, large inequities still exist. Minorities, new immigrants, and those with lower levels of education or income are much less likely to be screened. This review provides an overview of the commonly used tests for CRC screening, disparities in CRC screening, and promising methods at the individual, provider, and system levels to reduce these disparities...
2014: Journal of Carcinogenesis
https://www.readbyqxmd.com/read/25395880/esophageal-cancer-recent-advances-in-screening-targeted-therapy-and-management
#13
REVIEW
Puja Gaur, Min P Kim, Brian J Dunkin
The incidence of esophageal cancer remains on the rise worldwide and despite aggressive research in the field of gastrointestinal oncology, the survival remains poor. Much remains to be defined in esophageal cancer, including the development of an effective screening tool, identifying a good tumor marker for surveillance purposes, ways to target esophageal cancer stem cells as well as circulating tumor cells, and developing minimally invasive protocols to treat early-stage disease. The goal of this chapter is to highlight some of the recent advances and ongoing research in the field of esophageal cancer...
2014: Journal of Carcinogenesis
https://www.readbyqxmd.com/read/25225463/expression-of-epidermal-growth-factor-receptor-p53-bcl2-vascular-endothelial-growth-factor-cyclooxygenase-2-cyclin-d1-human-epidermal-receptor-2-and-ki-67-association-with-clinicopathological-profiles-and-outcomes-in-gallbladder-carcinoma
#14
Dinesh Chandra Doval, Saud Azam, Rupal Sinha, Ullas Batra, Anurag Mehta
BACKGROUND: The present study observed the expression levels of epidermal growth factor receptor (EGFR), p53, Bcl2, vascular endothelial growth factor (VEGF), cyclooxygenase-2 (cox-2), cyclin D1, human epidermal receptor-2 (HER-2) and Ki-67 in gallbladder carcinoma (GBC) and their association with clinicopathological profiles and disease outcomes. MATERIALS AND METHODS: Fifty consecutive samples of cholecystectomy/biopsies from GB bed (archived formalin fixed paraffin embedded tissue blocks of different stages of GBC) were included, and patient details related to their demographic profile, investigations, tumor profile, treatment, and follow-up were recorded...
2014: Journal of Carcinogenesis
https://www.readbyqxmd.com/read/25191137/doenjang-prepared-with-mixed-starter-cultures-attenuates-azoxymethane-and-dextran-sulfate-sodium-induced-colitis-associated-colon-carcinogenesis-in-mice
#15
Ji-Kang Jeong, Hee-Kyung Chang, Kun-Young Park
BACKGROUNDS: Doenjang is traditional Korean fermented soybean paste and widely known for its various health benefits including anticancer effect. In this study, we manufactured doenjang with the grain-type meju using probiotic mixed starter cultures of Aspegillus oryzae, Bacillus subtilis-SKm, and Lactococcus lactis-GAm to improve the qualities and beneficial properties of doenjang. MATERIALS AND METHODS: The inhibitory effects of the doenjang prepared with the grain-type meju using mixed starter cultures were investigated in azoxymethane (AOM) and dextran sulfate sodium (DSS)-induced colon carcinogenesis mice model...
2014: Journal of Carcinogenesis
https://www.readbyqxmd.com/read/25191136/circulating-tumor-cells-in-breast-cancer
#16
REVIEW
Geetha Pukazhendhi, Stefan Glück
Circulating tumor cell (CTC) measurement in peripheral blood of patients with breast cancer offers prognostic information. In this review, we will try to identify evidence that could be used for prognosis, predictive power to draw this tool to clinical utility. We reviewed 81 manuscripts, and categorized those in discovery datasets, prognostic factors in metastatic breast cancer, identification of clinical utility in early breast cancer and in novel approaches. With each patient responding differently to chemotherapy, more efficient markers would improve clinical outcome...
2014: Journal of Carcinogenesis
https://www.readbyqxmd.com/read/25191135/inhibitory-potential-of-methanolic-extracts-of-aristolochia-tagala-and-curcuma-caesia-on-hepatocellular-carcinoma-induced-by-diethylnitrosamine-in-balb-c-mice
#17
Khetbadei Lysinia Hynniewta Hadem, Rajeshwar Nath Sharan, Lakhan Kma
CONTEXT: Aristolochia tagala (AT) and Curcuma caesia (CC) have been used traditionally by local herbal practitioners for cancer treatment and as chief ingredients of many polyherbal formulations for various types of ailments. However, there is void in scientific study to evaluate their anti-cancer property. AIMS: The aim of this study was to evaluate the anti-carcinogenic properties of the crude methanolic extracts of roots of AT and rhizomes of CC in BALB/c mice exposed to a hepatocarcinogen, diethylnitrosamine (DEN)...
2014: Journal of Carcinogenesis
https://www.readbyqxmd.com/read/24799833/systems-oncology-a-new-paradigm-in-cancer-research
#18
Gopala Kovvali
No abstract text is available yet for this article.
2014: Journal of Carcinogenesis
https://www.readbyqxmd.com/read/24799832/novel-agents-in-the-management-of-castration-resistant-prostate-cancer
#19
REVIEW
Shruti Chaturvedi, Jorge A Garcia
Prostate cancer (PCa) is a leading cause of cancer mortality in men and despite high cure rates with surgery and/or radiation, 30-40% of patients will eventually develop advanced disease. Androgen deprivation is the first line therapy for standard of care for men with advanced disease. Eventually however all men will progress to castration-resistant prostate cancer (CRPC). Insight into the molecular mechanisms of androgen resistance has led to the development of alternative novel hormonal agents. Newer hormonal agents such as abiraterone, enzalutamide and TOK-001; and the first cancer vaccine, Sipuleucel T have been approved for use in men with CRPC...
2014: Journal of Carcinogenesis
https://www.readbyqxmd.com/read/24737952/targeted-therapy-in-gastrointestinal-malignancies
#20
REVIEW
Ravi Chhatrala, Yasmin Thanavala, Renuka Iyer
Increased understanding of cancer pathogenesis has identified several pathways that serve as potential targets for novel targeted agents in development. The selection of targeted cancer therapy based on biomarkers has instigated a new era of personalized medicine and changed the way we practice oncology. Many targeted agents are approved for treatment of gastrointestinal malignancies most targeting tumor angiogenesis, and many more are in different phases of development. Here we briefly summarize nine different targeted agents that are approved currently in the U...
2014: Journal of Carcinogenesis
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