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IEEE Transactions on Nanobioscience

Giulio Rosati, Matteo Scaramuzza, Elisabetta Pasqualotto, Alessandro De Toni, Carlo Reggiani, Alessandro Paccagnella
In this work, we demonstrate how an innovative, out-of-cleanroom customized CD/DVD fabrication process can be successfully used for mass production of biosensors with thin-film electrodes. We show that silver and gold electrodes can be used for impedimetric and voltammetric biosensing applications, both in presence and absence of a redox mediator. We modeled the redox/non-redox electrodes impedance through equivalent electrical circuits, and we evaluated their transfer function sensitivity with a one-factor-at-a-time approach...
October 10, 2016: IEEE Transactions on Nanobioscience
Nabiul Islam, Sudip Misra
The network of novel nano-material based nanodevices, known as nanoscale communication networks or nanonetworks has ushered a new communication paradigm in the terahertz band (0.1-10 THz). In this work, first we envisage an architecture of nanonetworks-based Coronary Heart Disease (CHD) monitoring, consisting of nano-macro interface (NM) and nanodevice-embedded Drug Eluting Stents (DESs), termed as nanoDESs. Next, we study the problem of asymmetric data delivery in such nanonetworks-based systems and propose a simple distance-aware power allocation algorithm, named catch-the-pendulum, which optimizes the energy consumption of nanoDESs for communicating data from the underlying nanonetworks to radio frequency (RF) based macro-scale communication networks...
October 5, 2016: IEEE Transactions on Nanobioscience
Milan Sasmal, Tapas K Maiti, Tarun K Bhattacharyya
Solution-processed bovine serum albumin conjugated with ZnO nanosphere (BCZ) have been synthesized for ultra-low level mercury ion detection. Simple drop casting technique was adopted to fabricate such a mercury ion (Hg2+) detection scheme. Morphological and optical characterization of the BCZ was performed by Transmission Electron Microscopy (TEM), UV-Vis and Fluorescence spectroscopic technique prior to device fabrication. The working principle of the BCZ device for Hg2+ detection depends upon the variation of conductance with various concentration of Hg2+...
September 29, 2016: IEEE Transactions on Nanobioscience
Buwen Cao, Jiawei Luo, Cheng Liang, Shulin Wang, Pingjian Ding
Identifying overlapping protein complexes in protein-protein interaction (PPI) networks can provide insight into cellular functional organization and thus elucidate underlying cellular mechanisms. Recently, various algorithms for protein complexes detection have been developed for PPI networks. However, majority of algorithms primarily depend on network topological feature and/or gene expression profile, failing to consider the inherent biological meanings between protein pairs. In this paper, we propose a novel method to detect protein complexes using pseudo-clique extension based on fuzzy relation (PCE-FR)...
September 20, 2016: IEEE Transactions on Nanobioscience
Arman Ahmadzadeh, Hamidreza Arjmandi, Andreas Burkovski, Robert Schober
This paper studies the problem of receiver modeling in molecular communication systems. We consider the diffusive molecular communication channel between a transmitter nanomachine and a receiver nano-machine in a fluid environment. The information molecules released by the transmitter nano-machine into the environment can degrade in the channel via a first-order degradation reaction and those that reach the receiver nanomachine can participate in a reversible bimolecular reaction with receiver receptor proteins...
September 14, 2016: IEEE Transactions on Nanobioscience
Leonardo Ricotti, Giulia Gori, Daniele Cei, Joana Costa, Giovanni Signore, Arti Ahluwalia
The study of nanomaterial translocation across epithelial barriers is often hindered by the low permeability of transwell membranes to nanoparticles. To address this issue ultra-thin poly(L-lactic acid) nanofilms with zero tortuosity micropores were developed for use in nanoparticle passage tests. In this study we demonstrate that microporous polymeric nanofilms allow a significantly higher passage of silver nanoparticles in comparison with commercial membranes normally used in Transwell inserts. A robust procedure for collecting free-standing nanofilms which enables their manipulation and use in lab-on-chip systems is described...
August 25, 2016: IEEE Transactions on Nanobioscience
Duong Nguyen, Yantao Fan, Yasemin Akay, Metin Akay
Tumor angiogenesis is a promising target for cancer treatment, because severing the supply of oxygen and nutrients to tumors halts tumor growth. Unfortunately, many anticancer drugs, including angiogenesis inhibitors, fail in clinical trials, despite showing high efficiency during in vitro and in vivo experiments. This inconsistency from in vitro and in vivo experiments to clinical trials represents a major obstacle in drug development and cancer treatment. Therefore, we set out to demonstrate how our rapid, stable, easy-touse three-dimensional (3D) in vitro angiogenesis model can be used to investigate tumor formation and implement drug screening...
August 16, 2016: IEEE Transactions on Nanobioscience
Guang-Qing Li, Zi Liu, Hong-Bin Shen, Dong-Jun Yu
As one of the most ubiquitous post-transcriptional modifications of RNA, N6-methyladenosine (m6A) plays an essential role in many vital biological processes. The identification of m6A sites in RNAs is significantly important for both basic biomedical research and practical drug development. In this study, we designed a computational-based method, called TargetM6A, to rapidly and accurately target m6A sites solely from the primary RNA sequences. Two new features, i.e., position-specific nucleotide / dinucleotide propensities (PSNP / PSDP), are introduced and combined with the traditional nucleotide composition (NC) feature to formulate RNA sequences...
August 10, 2016: IEEE Transactions on Nanobioscience
A Ozan Bicen, Ian F Akyildiz, Sasitharan Balasubramaniam, Yevgeni Koucheryavy
The use of intra/inter cellular calcium ion (Ca2+) signaling for molecular communication (MC) is investigated in this paper. In particular, the elevation of the intracellular Ca2+ concentration upon the external excitation, i.e., Ca2+ wave generation, and the intercellular propagation of Ca2+ wave over consecutive cells are studied for information transmission. The main objective of this paper is to develop a linear channel model for intra/inter cellular Ca2+ MC. In this context, the end-to-end Ca2+ MC system is studied under three blocks: the wave generation, the gap junctional (intercellular) propagation, and the intracellular propagation...
August 4, 2016: IEEE Transactions on Nanobioscience
Yu-Huei Cheng, Che-Nan Kuo, Ching-Ming Lai
mination of genetic variations of SNPs between members of a species. In many laboratories, PCR-RFLP (polymerase chain reaction-restriction fragment length polymorphism) is a usually used biotechnology for SNP genotyping, especially in small-scale basic research studies of complex genetic diseases. PCR-RFLP requires an available restriction enzyme at least for identify a target SNP and an effective primer pair conforms numerous constraints. However, the lots of restriction enzymes, tedious sequence and complicated constraints make the mining of available restriction enzymes and the design of effective primer pairs become a major challenge...
August 3, 2016: IEEE Transactions on Nanobioscience
Noah Goshi, Alaleh Narenji, Chris Bui, John L Mokili, Sam Kassegne
In this study, we investigate the effect of nucleotide content on the conductivity of plasmid length DNA molecular wires covalently bound to high aspect-ratio gold electrodes. The DNA wires were all between 2.20-2.35μm in length (>6000bp), and contained either 39%, 53%, or 64% GC base-pairs. We compared the current-voltage (I-V) and frequency-impedance characteristics of the DNA wires with varying GC content, and observed statistically significantly higher conductivity in DNA wires containing higher GC content in both AC and DC measurement methods...
July 28, 2016: IEEE Transactions on Nanobioscience
Bosheng Song, Mario J Perez-Jimenez, Gheorghe Paun, Linqiang Pan
Tissue P systems with channel states are a class of bio-inspired parallel computational models, where rules are used in a sequential manner (on each channel, at most one rule can be used at each step). In this work, tissue P systems with channel states working in a flat maximally parallel way are considered, where at each step, on each channel, a maximal set of applicable rules that pass from a given state to a unique next state, is chosen and each rule in the set is applied once. The computational power of such P systems is investigated...
July 27, 2016: IEEE Transactions on Nanobioscience
Gaetano Castorina, Laura Galluccio, Sergio Palazzo
In the last years, nano-communications have attracted much attention as a newly promising research field. In particular, molecular communications, which exploit molecular nodes, are a powerful tool to implement communication functionalities in environments where the use of electromagnetic waves becomes critical, e.g. in the human body. In molecular communications, molecules such as proteins, DNA and RNA sequences are used to carry information. To this aim a novel approach relies on the use of genetically modified bacteria to transport enhanced DNA strands, called plasmids, where information can be encoded...
July 27, 2016: IEEE Transactions on Nanobioscience
Vitaly Petrov, Dmitri Moltchanov, Ian Akyildiz, Yevgeni Koucheryavy
Flagellated bacteria have been suggested as one of the techniques to deliver information at nanoscales due to their ability to store massive amounts of data in their DNA strands and their mobility properties. In this paper, the propagation delay and message loss rates are mathematically derived for bacterial nanocommunications. The mobility pattern of the flagellated bacteria is investigated and a stochastic model of the bacteria mobility is developed. The proposed model is then used to derive the performance metrics of interest such as the link reliability as well as the propagation delay distribution for the case where N bacteria are used to deliver the message between two nanomachines...
July 18, 2016: IEEE Transactions on Nanobioscience
Mohammad Mahfuz, Dimitrios Makrakis, Hussein T Mouftah
Unlike normal diffusion, in anomalous diffusion, the movement of a molecule is described by the correlated random walk model where the mean square displacement of a molecule depends on the power law of time. In molecular communication (MC), there are many scenarios when the propagation of molecules cannot be described by normal diffusion process, where anomalous diffusion is a better fit. In this paper, the effects of anomalous subdiffusion on concentration-encoded molecular communication (CEMC) are investigated...
July 7, 2016: IEEE Transactions on Nanobioscience
Navideh Aghaei-Amirkhizi, Leila Moghaddam-Banaem, Mitra Athari-Allaf, Sodeh-Saadaat Sadjadi, Fariba Johari-Daha
The aim of this study is preparation of dendrimer encapsulated ytterbium-175 radio-nanoparticles and investigation of the compound chemical characteristic before and after the neutron irradiation and also study the in vivo biodistribution for targeted radiopharmaceutical dose delivery to solid tumors. For preparation of dendrimer-metal nanocomposite, a dendrimer compound containing an average of 55 Yb+3 ions per dendrimer was prepared. The synthesized encapsulated ytterbium irradiated by neutron for 2h at 3×1011 n...
July 7, 2016: IEEE Transactions on Nanobioscience
Mahendran Subramanian, Gillian Pearce, Ozge Guldu, Volkan Tekin, Arkadiusz Miaskowski, Omer Aras, Perihan Unak
Herein, we present a pilot study concerning the use of fluorodeoxy glucose conjugated magnetite nanoparticles (FDG-mNP ) as a potential agent in magnetic nanoparticle mediated neuroblastoma cancer cell hyperthermia. This approach makes use of the 'Warburg effect', utilising the fact that cancer cells have a higher metabolic rate than normal cells. FDG-mNP were synthesized, then applied to the SH-SY5Y neuroblastoma cancer cell line and exposed to an AC magnetic field. 3D Calorimetry was performed on the FDG-mNP compound...
July 7, 2016: IEEE Transactions on Nanobioscience
Nevendra K Chetty, Louis Chonco, Nelson Ijumba, Leon Chetty, Thavendran Govender, Raveen Parboosing, Innocent E Davidson
Corona discharges are commonly utilized for numerous practical applications, including bio-technological ones. The corona induced transfer of normally impermeant molecules into the interior of biological cells has recently been successfully demonstrated. The exact nature of the interaction of the corona discharge with a cell membrane is still unknown, however, previous studies have suggested that it is either the electric fields produced by ions or the chemical interaction of the reactive species that result in the disruption of the cell membrane...
June 28, 2016: IEEE Transactions on Nanobioscience
Jun Li, Yourui Huang, Jiachang Xu
The spiking neural P systems (SN P systems, for short) refer to the parallel-distributed bio-computing models, which have currently becoming research hotspots in the biocomputing field. In computing systems, logical operations and arithmetic operations are the most important parts, while the decoders composed of logical circuits are their indispensable parts. In this paper, considering the characteristics of SN P systems, a computing model for the general single-input singleoutput n
June 23, 2016: IEEE Transactions on Nanobioscience
Xuedong Zheng, Bin Wang, Changjun Zhou, Xiaopeng Wei, Qiang Zhang
The redundant residue number system is introduced into DNA computing in order to overcome the negative effect caused by the instability of the biochemical reactions and the error hybridizations. Based on the Adleman-Lipton model and a special 3-moduli set, the DNA encoding scheme for redundant residue numbers is presented and the DNA algorithm of one-digit error detection is proposed. The parallel DNA arithmetic operation can be realized in redundant residue number system with error detection, and which can improve the reliability of DNA computing and simplify the DNA encoding scheme...
June 14, 2016: IEEE Transactions on Nanobioscience
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