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IEEE Transactions on Nanobioscience

Burhan Gulbahar, Gorkem Memisoglu
Biological particle tracking systems monitor cellular processes or particle behaviors with the great accuracy. The emissions of fluorescent molecules or direct images of particles are captured with cameras or photodetectors. The current imaging systems have challenges in detection, collection, and analysis of imaging data, penetration depth, and complicated set-ups. In this paper, a signaling-based nanoscale acousto-optic radar and microfluidic multiple particle tracking (MPT) system is proposed based on the theoretical design providing nanoscale optical modulator with vibrating Förster resonance energy transfer and vibrating cadmium selenide/zinc sulfide quantum dots (QDs) on graphene resonators...
December 2017: IEEE Transactions on Nanobioscience
Rosella Cataldo, Eleonora Alfinito, Lino Reggiani
Aptamers are single stranded DNA, RNA, or peptide sequences having the ability to bind several specific targets (proteins, molecules as well as ions). Therefore, aptamer production and selection for therapeutic and diagnostic applications is very challenging. Usually, they are generated in vitro, although computational approaches have been recently developed for the in silico production. Despite these efforts, the mechanism of aptamer-ligand formation is not completely clear, and producing high-affinity aptamers is still quite difficult...
December 2017: IEEE Transactions on Nanobioscience
Hong Peng, Ru Chen, Jun Wang, Xiaoxiao Song, Tao Wang, Fan Yang, Zhang Sun
This paper proposes an extension of spiking neural P systems with rules on synapses (SNP-RS systems) working in competitive strategy, called competitive SNP-RS (CSNP-RS systems). In CSNP-RS systems, the spikes are viewed as a kind of competitive resources, and the rules on different synapses will compete the spikes (resources) in neurons. A new strategy is considered: the total amount of spikes consumed by these rules should be greater than or equal to the generated amount of spikes. There are two cases to chosen one rule non-deterministically: 1) two or more rules on the same synapse are enabled; and 2) two or more rules on the different synapses are enabled, and the number of spikes contained in neuron is smaller than the number of spikes consumed by these rules...
December 2017: IEEE Transactions on Nanobioscience
Vahid Jamali, Arman Ahmadzadeh, Robert Schober
Symbol synchronization refers to the estimation of the start of a symbol interval and is needed for reliable detection. In this paper, we develop several symbol synchronization schemes for molecular communication (MC) systems where we consider some practical challenges, which have not been addressed in the literature yet. In particular, we take into account that in MC systems, the transmitter may not be equipped with an internal clock and may not be able to emit molecules with a fixed release frequency. Such restrictions hold for practical nanotransmitters, e...
December 2017: IEEE Transactions on Nanobioscience
Stefanus Arinno Wirdatmadja, Michael Taynnan Barros, Yevgeni Koucheryavy, Josep Miquel Jornet, Sasitharan Balasubramaniam
In recent years, numerous research efforts have been dedicated toward developing efficient implantable devices for brain stimulation. However, there are limitations and challenges with the current technologies. They include neuron population stimulation instead of single neuron level, the size, the biocompatibility, and the device lifetime reliability in the patient's brain. We have recently proposed the concept of wireless optogenetic nanonetworking devices (WiOptND) that could address the problem of long term deployment, and at the same time target single neuron stimulation utilizing ultrasonic as a mode for energy harvesting...
December 2017: IEEE Transactions on Nanobioscience
Dhivya Ravichandran, Padmapriya Praveenkumar, John Bosco Balaguru Rayappan, Rengarajan Amirtharajan
In this technological era, it is highly essential to protect the digital medical data from the fraud and forgery as they are transmitted over the public channel. Also with the increased data traffic, it is hard to transmit the entire bulky medical data. New methods have come into the scene to reduce the traffic while maintaining the sufficient level of security. Partial encryption is one of the methods which selectively encrypt the bulky medical image. Meanwhile, if the same medical image is needed to be reused for another diagnosis, then it is recommended to protect the entire medical image...
December 2017: IEEE Transactions on Nanobioscience
Renee F Keller, Pinar Kanlikilicer, Andrei Dragomir, Yantao Fan, Yasemin M Akay, Metin Akay
Maternal smoking during pregnancy is associated with developmental, cognitive, and behavioral disorders, including low birth weight, attention deficit hyperactivity disorder, learning disabilities, and drug abuse later in life. Nicotine activates the reward-driven behavior characteristic of drug abuse. Dopaminergic (DA) neurons originating from the ventral tegmental area (VTA) of the brain, which are stimulated by nicotine and other stimuli, are widely implicated in the natural reward pathway that is known to contribute to addiction...
December 2017: IEEE Transactions on Nanobioscience
Reza Mosayebi, Vahid Jamali, Nafiseh Ghoroghchian, Robert Schober, Masoumeh Nasiri-Kenari, Mahdieh Mehrabi
In this paper, we consider abnormality detection via diffusive molecular communications (MCs) for a network consisting of several sensors and a fusion center (FC). If a sensor detects an abnormality, it injects a number of molecules into the medium which is proportional to its sensing output. Two transmission schemes for releasing molecules into the medium are considered. In the first scheme, each sensor releases a different type of molecule (DTM), whereas in the second scheme, all sensors release the same type of molecule (STM)...
December 2017: IEEE Transactions on Nanobioscience
Irena Cosic, Drasko Cosic
Tuning element relief patches (TERPs) are silicon-based titanium salt infused adhesive patches that have been developed by Tuning Element. A number of anecdotal reports have shown that TERPs diffuse pain, including chronic, inflammatory, and neuropathic. Pain is a very complex biochemical and electrical process involving sensory part, nerve transmission, and brain perception of pain. We concentrated our research on nerve transmission, which is electrical signal along the nerve (axon). This electrical signal is created by a complex activity of opening and closing of pain related ion channels and redistribution of electrically charged ions on the nerve cell membrane...
December 2017: IEEE Transactions on Nanobioscience
Yifan Chen, Shaolong Shi, Xin Yao, Tadashi Nakano
We propose a new computing-inspired bio-detection framework called touchable computing (TouchComp). Under the rubric of TouchComp, the best solution is the cancer to be detected, the parameter space is the tissue region at high risk of malignancy, and the agents are the nanorobots loaded with contrast medium molecules for tracking purpose. Subsequently, the cancer detection procedure (CDP) can be interpreted from the computational optimization perspective: a population of externally steerable agents (i.e., nanorobots) locate the optimal solution (i...
December 2017: IEEE Transactions on Nanobioscience
I Benammar, R Salhi, J-L Deschanvres, R Maalej
The effects of solvent on the suspension stability of titanium dioxide (TiO2) nanoparticle (NP)-doped rare-earth elements (Er and Yb) were evaluated. Pure and doped TiO2 NPs were successfully prepared by the sol-gel method under the supercritical drying conditions of ethanol. Doped nanopowders were prepared with 5 mol% Er or 5 mol% Yb concentration, and co-doped nanopowders were prepared with fixed 5 mol% Er concentration and various Yb concentrations of 5 and 10 mol%. TiO2 NP suspensions with diverse solvents, such as water, ethanol, methanol, and butanol, were prepared...
December 2017: IEEE Transactions on Nanobioscience
Afef Mdhaffar, Ismael Bouassida Rodriguez, Khalil Charfi, Leila Abid, Bernd Freisleben
This paper presents a novel health analysis approach for heart failure prediction. It is based on the use of complex event processing (CEP) technology, combined with statistical approaches. A CEP engine processes incoming health data by executing threshold-based analysis rules. Instead of having to manually set up thresholds, our novel statistical algorithm automatically computes and updates thresholds according to recorded historical data. Experimental results demonstrate the merits of our approach in terms of speed, precision, and recall...
December 2017: IEEE Transactions on Nanobioscience
Fathi Kallel, Ahmed Ben Hamida
The performances of medical image processing techniques, in particular CT scans, are usually affected by poor contrast quality introduced by some medical imaging devices. This suggests the use of contrast enhancement methods as a solution to adjust the intensity distribution of the dark image. In this paper, an advanced adaptive and simple algorithm for dark medical image enhancement is proposed. This approach is principally based on adaptive gamma correction using discrete wavelet transform with singular-value decomposition (DWT-SVD)...
December 2017: IEEE Transactions on Nanobioscience
Steven Kinio, James K Mills
This paper presents the design and experimental performance of a microelectrode-based device to selectively lyse cells in a flow in a microfluidic channel. Localized cell lysis is achieved by utilizing "irreversible electroporation", in which cells are exposed to high magnitude electric pulses. Localized cell lysis in a flow has research applications and may allow for removal of harmful cells such as circulating tumor cells from blood. Due to the dependence of this technique on the magnitude of the applied electric field, lethal electric field regions can be localized in the channel by calibration of the applied voltage...
October 17, 2017: IEEE Transactions on Nanobioscience
H Kraiem, F Zouari, R Ben Abderrazek, Y Manon, M El Ayeb, L Fillaudeau, J Bedoui, B Bouhaouala-Zahar
Recombinant human granulocyte colony-stimulating factor (rhG-CSF) has been increasingly recognized from among one of the most abundant families of biosimilars. Upon long-term storage, rhG-CSF is subject to subtle chemical modifications that rapidly occur and, in particular, produce deaminated variants with divergent charge. Indeed, changes in charge from glutamine deamination may alter the way rhG-SCF will refold and the structure of resulting molecule. To assess this charge heterogeneity, 2D gel electrophoresis has limited application...
October 16, 2017: IEEE Transactions on Nanobioscience
Olfa Ghribi, Lamia Sellami, Mohamed Ben Slima, Ahmed Ben Hamida, Chokri Mhiri, Keireddine Ben Mahfoudh
Multiple sclerosis is one of the most common neurological diseases in young people. This paper dealt with an automatic biomedical aided tool involving volumetric segmentation of Multiple Sclerosis lesions. To meet this challenge, our proposed methodology requires one preliminary cerebral zones segmentation performed using a new Gaussian Mixture Model based on various databases atlases. Afterwards, lesion segmentation begins with the estimation of a lesion map which is then subjected to threshold constraints and refined by a new lesion expansion algorithm...
October 16, 2017: IEEE Transactions on Nanobioscience
Francis George C Cabarle, Henry N Adorna, Min Jiang, Xiangxiang Zeng
Spiking neural P systems (in short, SN P systems) are models of computation inspired by biological spiking neurons. SN P systems have neurons as spike processors which are placed on the nodes of a directed and static graph (the edges in the graph are the synapses). In this work, we introduce a variant called SN P systems with scheduled synapses (in short, SSN P systems). SSN P systems are inspired and motivated by the structural dynamism of biological synapses, while incorporating ideas from nonstatic (i.e...
October 16, 2017: IEEE Transactions on Nanobioscience
Naveed A Abbasi, Ozgur B Akan
Molecular communication is an important tool to understand biological communications with many promising applications in Internet of Bio-Nano Things (IoBNT). The insulinglucose system is of key significance among the major intrabody nanonetworks since it fulfills metabolic requirements of the body. Study of biological networks from information and communication theoretical (ICT) perspective is necessary for their introduction in the IoBNT framework. Therefore, the objective of this work is to provide and analyze for the first time in literature, a simple molecular communication model of the human insulin-glucose system from ICT perspective...
October 11, 2017: IEEE Transactions on Nanobioscience
Aby K George, Harpreet Singh
Decision-making systems are an integral part of any autonomous device. With the recent developments in bionanorobots, smart drugs, and engineered viruses, there is an immediate need of decision-making systems which are biocompatible in nature. DNA is considered a perfect candidate for designing the computing systems in such decision-making systems because of their bio-compatibility and programmability. Complex biological systems can be easily modeled/controlled using fuzzy logic operations with the help of linguistic rules...
October 9, 2017: IEEE Transactions on Nanobioscience
Rupesh Singh, Srinivas Rajaraman, Madhusudhanan Balasubramanian
A novel nanoparticle mediated methodology for laser photocoagulation of the inner retina to achieve tissue selective treatment is presented. METHODS: Transport of 527, 577, and 810 nm laser, heat deposition, and eventual thermal damage in vitreous, retina, RPE, choroid, and sclera were modeled using Bouguer-Beer-Lambert law of absorption and solved numerically using the finite volume method. Nanoparticles were designed using Mie theory of scattering. Performance of the new photocoagulation strategy using gold nanospheres and gold-silica nanoshells was compared with that of conventional methods without nanoparticles...
October 2017: IEEE Transactions on Nanobioscience
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