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IEEE Transactions on Nanobioscience

K Solarczyk, K Wojcik, P Kulakowski
In the above paper [1], an exponent is missing from equations (5) and (6). The correct version of the equations are as follows.
March 2018: IEEE Transactions on Nanobioscience
A Ozan Bicen, Janne J Lehtomaki, Ian F Akyildiz
Molecular communication (MC) over a microfluidic channel with flow is investigated based on Shannon's channel capacity theorem and Fick's laws of diffusion. Specifically, the sum capacity for MC between a single transmitter and multiple receivers (broadcast MC) is studied. The transmitter communicates by using different types of signaling molecules with each receiver over the microfluidic channel. The transmitted molecules propagate through microfluidic channel until reaching the corresponding receiver. Although the use of different types of molecules provides orthogonal signaling, the sum broadcast capacity may not scale with the number of the receivers due to physics of the propagation (interplay between convection and diffusion based on distance)...
March 2018: IEEE Transactions on Nanobioscience
Keyvan Aghababaiyan, Vahid Shah-Mansouri, Behrouz Maham
Novel nano-scale communication techniques are inspired by biological systems. Neuro-spike communication is an example of this communication paradigm which transfers vital information about external and internal conditions of the body through the nervous system. The analysis of this communication paradigm is beneficial to exploit in the artificial neural systems where nano-machines are linked to neurons to treat the neurodegenerative diseases. In these networks, nano-machines are used to replace the damaged segments of the nervous system and they exactly behave like biological entities...
March 2018: IEEE Transactions on Nanobioscience
Qi Gao, Yuqiang Fang, Shiqing Zhang, Hung-Wing Li, Ken K L Yung, King Wai Chiu Lai
Beta amyloid ( ) peptide, which is a common neuropathological hallmark deposit in the brain of patients with Alzheimer's disease, typically comprises 39-43 amino acid residues. peptides exist as isoforms of and with various lengths. In this research, atomic force microscopy (AFM) was applied to investigate aggregations in Hank's Balanced Salt Solution. Toxic effect of oligomer was investigated in live SH-SY5Y neuroblastoma cells by characterizing cell morphology and cell mechanics using high-resolution AFM scanning...
March 2018: IEEE Transactions on Nanobioscience
Takayuki Hoshino, Moto Yoshioka, Akira Wagatsuma, Hiroki Miyazako, Kunihiko Mabuchi
Electroporation, a physical transfection method to introduce genomic molecules in selective living cells, could be implemented by microelectrode devices. A local electric field generated by a finer electrode can induces cytomembrane poration in the electrode vicinity. To employ fine, high-speed scanning electrodes, we developed a fine virtual cathode pattern, which was generated on a cell adhesive surface of 100-nm-thick SiN membrane by inverted-electron beam lithography. The SiN membrane works as both a vacuum barrier and the display screen of the virtual cathode...
March 2018: IEEE Transactions on Nanobioscience
Sumanta Ray, Syed Alberuni, Ujjwal Maulik
In this paper, we have developed a framework for detection of protein-protein interactions (PPI) between Hepatitis-C virus (HCV) and human proteins based on PPI and gene ontology based information of the HCV infected proteins. First, a bipartite interaction network is formed between HCV proteins and human host proteins. Next, we have analyzed different topological properties of the interaction network and observed that degree of HCV-interacting proteins is significantly higher than non-interacting host proteins...
March 2018: IEEE Transactions on Nanobioscience
Murat Kuscu, Ozgur B Akan
Molecular Communication (MC) is a bio-inspired communication technique that uses molecules as a method of information transfer among nanoscale devices. MC receiver is an essential component having profound impact on the communication system performance. However, the interaction of the receiver with information bearing molecules has been usually oversimplified in modeling the reception process and developing signal detection techniques. In this paper, we focus on the signal detection problem of MC receivers employing receptor molecules to infer the transmitted messages encoded into the concentration of molecules, i...
March 2018: IEEE Transactions on Nanobioscience
Peter Gawthrop
A new approach to compute the equilibria and the steady-states of biomolecular systems modeled by bond graphs is presented. The approach is illustrated using a model of a biomolecular cycle representing a membrane transporter and a model of the mitochondrial electron transport chain.
March 2018: IEEE Transactions on Nanobioscience
Ge Chang, Lin Lin, Hao Yan
Current studies on modulation and detection schemes in molecular communication mainly focus on the scenarios with static transmitters and receivers. However, mobile molecular communication is needed in many envisioned applications, such as target tracking and drug delivery. Until now, investigations about mobile molecular communication have been limited. In this paper, a static transmitter and a mobile bacterium-based receiver performing random walk are considered. In this mobile scenario, the channel impulse response changes due to the dynamic change of the distance between the transmitter and the receiver...
March 2018: IEEE Transactions on Nanobioscience
Xiguo Yuan, Junying Zhang, Liying Yang, Jun Bai, Peizhen Fan
Analyzing copy number variations (CNVs) from next-generation sequencing (NGS) data has become a common approach to detect disease susceptibility genes. The main challenge is how to utilize the NGS data with limited coverage depth to detect significant CNVs. Here, we introduce a new statistical method, the derivative of correlation coefficient (DCC), to detect significant CNVs that recurrently occur in multiple samples using read depth signals. We use a sliding window to calculate a correlation coefficient for each genome bin, and compute corresponding derivatives by fitting curves to the correlation coefficient...
March 2018: IEEE Transactions on Nanobioscience
Davud Asemani, Dieter Haemmerich
Nanoparticles, such as liposomes, allow more targeted drug delivery for improved efficacy and/or reduced toxicity in both passive (e.g., Doxil) or active [e.g., thermo-sensitive liposomes (TSL)] release forms compared with unencapsulated drugs (i.e., conventional chemotherapy). Optimization and evaluation of these different drug delivery systems are experimentally challenging because of varying tissue parameters as well as limited avaiability of experimental data. Here, we present a novel unified mathematical model that can simulate various liposomal drug delivery systems and unencapsulated drugs with a single set of equations...
March 2018: IEEE Transactions on Nanobioscience
Burhan Gulbahar, Gorkem Memisoglu
Biological particle tracking systems monitor cellular processes or particle behaviors with the great accuracy. The emissions of fluorescent molecules or direct images of particles are captured with cameras or photodetectors. The current imaging systems have challenges in detection, collection, and analysis of imaging data, penetration depth, and complicated set-ups. In this paper, a signaling-based nanoscale acousto-optic radar and microfluidic multiple particle tracking (MPT) system is proposed based on the theoretical design providing nanoscale optical modulator with vibrating Förster resonance energy transfer and vibrating cadmium selenide/zinc sulfide quantum dots (QDs) on graphene resonators...
December 2017: IEEE Transactions on Nanobioscience
Rosella Cataldo, Eleonora Alfinito, Lino Reggiani
Aptamers are single stranded DNA, RNA, or peptide sequences having the ability to bind several specific targets (proteins, molecules as well as ions). Therefore, aptamer production and selection for therapeutic and diagnostic applications is very challenging. Usually, they are generated in vitro, although computational approaches have been recently developed for the in silico production. Despite these efforts, the mechanism of aptamer-ligand formation is not completely clear, and producing high-affinity aptamers is still quite difficult...
December 2017: IEEE Transactions on Nanobioscience
Hong Peng, Ru Chen, Jun Wang, Xiaoxiao Song, Tao Wang, Fan Yang, Zhang Sun
This paper proposes an extension of spiking neural P systems with rules on synapses (SNP-RS systems) working in competitive strategy, called competitive SNP-RS (CSNP-RS systems). In CSNP-RS systems, the spikes are viewed as a kind of competitive resources, and the rules on different synapses will compete the spikes (resources) in neurons. A new strategy is considered: the total amount of spikes consumed by these rules should be greater than or equal to the generated amount of spikes. There are two cases to chosen one rule non-deterministically: 1) two or more rules on the same synapse are enabled; and 2) two or more rules on the different synapses are enabled, and the number of spikes contained in neuron is smaller than the number of spikes consumed by these rules...
December 2017: IEEE Transactions on Nanobioscience
Vahid Jamali, Arman Ahmadzadeh, Robert Schober
Symbol synchronization refers to the estimation of the start of a symbol interval and is needed for reliable detection. In this paper, we develop several symbol synchronization schemes for molecular communication (MC) systems where we consider some practical challenges, which have not been addressed in the literature yet. In particular, we take into account that in MC systems, the transmitter may not be equipped with an internal clock and may not be able to emit molecules with a fixed release frequency. Such restrictions hold for practical nanotransmitters, e...
December 2017: IEEE Transactions on Nanobioscience
Stefanus Arinno Wirdatmadja, Michael Taynnan Barros, Yevgeni Koucheryavy, Josep Miquel Jornet, Sasitharan Balasubramaniam
In recent years, numerous research efforts have been dedicated toward developing efficient implantable devices for brain stimulation. However, there are limitations and challenges with the current technologies. They include neuron population stimulation instead of single neuron level, the size, the biocompatibility, and the device lifetime reliability in the patient's brain. We have recently proposed the concept of wireless optogenetic nanonetworking devices (WiOptND) that could address the problem of long term deployment, and at the same time target single neuron stimulation utilizing ultrasonic as a mode for energy harvesting...
December 2017: IEEE Transactions on Nanobioscience
Dhivya Ravichandran, Padmapriya Praveenkumar, John Bosco Balaguru Rayappan, Rengarajan Amirtharajan
In this technological era, it is highly essential to protect the digital medical data from the fraud and forgery as they are transmitted over the public channel. Also with the increased data traffic, it is hard to transmit the entire bulky medical data. New methods have come into the scene to reduce the traffic while maintaining the sufficient level of security. Partial encryption is one of the methods which selectively encrypt the bulky medical image. Meanwhile, if the same medical image is needed to be reused for another diagnosis, then it is recommended to protect the entire medical image...
December 2017: IEEE Transactions on Nanobioscience
Renee F Keller, Pinar Kanlikilicer, Andrei Dragomir, Yantao Fan, Yasemin M Akay, Metin Akay
Maternal smoking during pregnancy is associated with developmental, cognitive, and behavioral disorders, including low birth weight, attention deficit hyperactivity disorder, learning disabilities, and drug abuse later in life. Nicotine activates the reward-driven behavior characteristic of drug abuse. Dopaminergic (DA) neurons originating from the ventral tegmental area (VTA) of the brain, which are stimulated by nicotine and other stimuli, are widely implicated in the natural reward pathway that is known to contribute to addiction...
December 2017: IEEE Transactions on Nanobioscience
Reza Mosayebi, Vahid Jamali, Nafiseh Ghoroghchian, Robert Schober, Masoumeh Nasiri-Kenari, Mahdieh Mehrabi
In this paper, we consider abnormality detection via diffusive molecular communications (MCs) for a network consisting of several sensors and a fusion center (FC). If a sensor detects an abnormality, it injects a number of molecules into the medium which is proportional to its sensing output. Two transmission schemes for releasing molecules into the medium are considered. In the first scheme, each sensor releases a different type of molecule (DTM), whereas in the second scheme, all sensors release the same type of molecule (STM)...
December 2017: IEEE Transactions on Nanobioscience
Irena Cosic, Drasko Cosic
Tuning element relief patches (TERPs) are silicon-based titanium salt infused adhesive patches that have been developed by Tuning Element. A number of anecdotal reports have shown that TERPs diffuse pain, including chronic, inflammatory, and neuropathic. Pain is a very complex biochemical and electrical process involving sensory part, nerve transmission, and brain perception of pain. We concentrated our research on nerve transmission, which is electrical signal along the nerve (axon). This electrical signal is created by a complex activity of opening and closing of pain related ion channels and redistribution of electrically charged ions on the nerve cell membrane...
December 2017: IEEE Transactions on Nanobioscience
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