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Journal of Negative Results in Biomedicine

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https://www.readbyqxmd.com/read/27802801/examining-if-being-overweight-really-confers-protection-against-dementia-sixty-four-year-follow-up-of-participants-in-the-glasgow-university-alumni-cohort-study
#1
G David Batty, Bruna Galobardes, John M Starr, Mona Jeffreys, George Davey Smith, Tom C Russ
BACKGROUND: Recent large-scale studies suggest that obesity and overweight may confer protection against future dementia. This observation could, however, be generated by reverse causality. That is, weight loss in the incipient phase of dementia ascribed to diminished self-care, including sub-optimal nutrition, would have the effect of generating such an inverse association. One approach to circumventing this problem would be to measure weight in a population which is young enough to be free of the symptoms of dementia which is then followed up for dementia occurrence over many decades...
November 2, 2016: Journal of Negative Results in Biomedicine
https://www.readbyqxmd.com/read/27784318/dietary-phosphate-supplement-does-not-rescue-skeletal-phenotype-in-a-mouse-model-for-craniometaphyseal-dysplasia
#2
Yaling Liu, Eliane H Dutra, Ernst J Reichenberger, I-Ping Chen
BACKGROUND: Mutations in the human progressive ankylosis gene (ANKH; Mus musculus ortholog Ank) have been identified as cause for craniometaphyseal dysplasia (CMD), characterized by progressive thickening of craniofacial bones and flared metaphyses of long bones. We previously reported a knock-in (KI) mouse model (Ank (KI/KI)) for CMD and showed transiently lower serum phosphate (Pi) as well as significantly higher mRNA levels of fibroblast growth factor 23 (Fgf23) in Ank (KI/KI) mice...
October 26, 2016: Journal of Negative Results in Biomedicine
https://www.readbyqxmd.com/read/27687253/polymorphism-rs7555523-in-transmembrane-and-coiled-coil-domain-1-tmco1-is-not-a-risk-factor-for-primary-open-angle-glaucoma-in-a-saudi-cohort
#3
Altaf A Kondkar, Ahmed Mousa, Taif A Azad, Tahira Sultan, Abdullah Alawad, Saleh Altuwaijri, Saleh A Al-Obeidan, Khaled K Abu-Amero
BACKGROUND: We investigated whether polymorphism rs7555523 (A > C) in human transmembrane and coiled-coil domain 1 (TMCO1) gene is a risk factor for primary open angle glaucoma (POAG) in a Saudi cohort. METHODS: A cohort of 87 unrelated POAG cases and 94 control subjects from Saudi Arabia were genotyped using Taq-Man® assay. The association of genotypes with POAG and other glaucoma specific clinical indices was investigated. RESULTS: The genotype and allele frequency of polymorphism rs7555523 at TMCO1 did not show any statistically significant association with POAG as compared to controls...
September 29, 2016: Journal of Negative Results in Biomedicine
https://www.readbyqxmd.com/read/26841794/adamts-18-in-the-host-tissues-exerts-little-effect-on-breast-tumor-progress-in-a-murine-4t1-breast-cancer-model
#4
Min Liu, Tiantian Lu, Fang Jing, Suying Dang, Wei Zhang
BACKGROUND: In this study, we aimed to identify a novel extracellular proteinase ADAMTS-18 that could be a potential tumor suppressor gene. RESULTS: We successfully constructed Adamts-18 knockout mice with BALB / c background. RT-PCR analysis showed syngeneic mammary tumor cell line 4 T1 per se has weakly endogenous ADAMTS-18 expression. Orthotopic inoculation of 4 T1 cells within the mammary fat pad of host mice, we found no significant difference in tumor growth and metastasis between Adamts-18 knockout mice and widetype control...
February 3, 2016: Journal of Negative Results in Biomedicine
https://www.readbyqxmd.com/read/27582019/low-density-lipoprotein-receptor-related-protein-5-gene-polymorphisms-and-osteoporosis-in-thai-menopausal-women
#5
Anong Kitjaroentham, Hathairad Hananantachai, Benjaluck Phonrat, Sangchai Preutthipan, Rungsunn Tungtrongchitr
BACKGROUND: Osteoporosis, characterized by low bone mineral density (BMD) and high bone fracture risk, is prevalent in Thai menopausal women. Genetic factors are known to play a key role in BMD. Low density lipoprotein receptor-related protein 5 (LRP5), a co-receptor in the Wnt/beta-catenin pathway, is involved in many aspects of bone biology. As coding single nucleotide polymorphisms (cSNPs) of LRP5, including A1330V (rs3736228), and Asian-related Q89R (rs41494349) and N740N (rs2306862), are associated with lowered BMD, this study aimed to determine the relationship between these LRP5 polymorphisms and BMD in 277 Thai menopausal women...
2016: Journal of Negative Results in Biomedicine
https://www.readbyqxmd.com/read/27553084/evaluation-of-a-novel-virtual-screening-strategy-using-receptor-decoy-binding-sites
#6
Hershna Patel, Andreas Kukol
Virtual screening is used in biomedical research to predict the binding affinity of a large set of small organic molecules to protein receptor targets. This report shows the development and evaluation of a novel yet straightforward attempt to improve this ranking in receptor-based molecular docking using a receptor-decoy strategy. This strategy includes defining a decoy binding site on the receptor and adjusting the ranking of the true binding-site virtual screen based on the decoy-site screen. The results show that by docking against a receptor-decoy site with Autodock Vina, improved Receiver Operator Characteristic Enrichment (ROCE) was achieved for 5 out of fifteen receptor targets investigated, when up to 15 % of a decoy site rank list was considered...
2016: Journal of Negative Results in Biomedicine
https://www.readbyqxmd.com/read/27452910/gastrokine-1-mrna-in-human-sera-is-not-informative-biomarker-for-gastric-cancer
#7
Valentina Villano, Chiara Stella Di Stadio, Antonella Federico, Filomena Altieri, Giuseppina Miselli, Maurizio De Palma, Emilia Rippa, Paolo Arcari
BACKGROUND: We aimed to ascertain if Gastrokine 1 mRNA in the sera of patients with gastric cancer might be an informative biomarker for the disease. RESULTS: Analysis of GKN1 mRNA in serum samples from healthy individuals (n = 23) and from patients with diagnosis of gastric cancer (n = 16), performed by using absolute quantification based on standard curve method, did not show any significative statistical difference between the two unpaired group of individuals...
2016: Journal of Negative Results in Biomedicine
https://www.readbyqxmd.com/read/27435165/is-mindfulness-protective-against-ptsd-a-neurocognitive-study-of-25-tsunami-disaster-survivors
#8
Christina Hagen, Lars Lien, Edvard Hauff, Trond Heir
BACKGROUND: It has been suggested that mindfulness is a protective factor that buffers individuals from experiencing severe posttraumatic stress following exposure to a trauma. We aimed to examine the association between dispositional (trait) mindfulness and posttraumatic stress in individuals who had been exposed to the trauma of a natural disaster. METHOD: A disaster group (n = 25) consisting of Norwegian tourists who survived the 2004 South East Asian tsunami at a location with high mortality rates was recruited...
2016: Journal of Negative Results in Biomedicine
https://www.readbyqxmd.com/read/27401915/age-is-not-associated-with-intracranial-haemorrhage-in-patients-with-mild-traumatic-brain-injury-and-oral-anticoagulation
#9
Thomas C Sauter, Stephan Ziegenhorn, Sufian S Ahmad, Wolf E Hautz, Meret E Ricklin, Alexander Benedikt Leichtle, Georg-Martin Fiedler, Dominik G Haider, Aristomenis K Exadaktylos
BACKGROUND: Patients admitted to emergency departments with traumatic brain injury (TBI) are commonly being treated with oral anticoagulants. In contrast to patients without anticoagulant medication, no guidelines, scores or recommendations exist for the management of mild traumatic brain injury in these patients. We therefore tested whether age as one of the high risk factors of the Canadian head CT rule is applicable to a patient population on oral anticoagulants. METHODS: This cross-sectional analysis included all patients with mild TBI and concomitant oral anticoagulant therapy admitted to the Emergency Department, Inselspital Bern, Switzerland, from November 2009 to October 2014 (n = 200)...
2016: Journal of Negative Results in Biomedicine
https://www.readbyqxmd.com/read/27211793/investigation-of-sla4a3-as-a-candidate-gene-for-human-retinal-disease
#10
Louise M Downs, Andrew R Webster, Anthony T Moore, Michel Michaelides, Robin R Ali, Alison J Hardcastle, Cathryn S Mellersh
SLC4A3 has been shown to cause retinal degeneration in a genetically engineered knockout mouse, and in a naturally occurring form of canine progressive retinal atrophy considered to be the equivalent of retinitis pigmentosa in humans (RP). This study was undertaken to investigate if SLC4A3 coding variants were implicated in human retinal degeneration. SLC4A3 exons were amplified and sequenced in 200 patients with autosomal recessive retinal degeneration who had no known molecular diagnosis for their condition, which included 197 unrelated individuals with suspected RP and three individuals with other forms of retinal disease...
2016: Journal of Negative Results in Biomedicine
https://www.readbyqxmd.com/read/27164957/noise-trauma-and-systemic-application-of-the-selective-glucocorticoid-receptor-modulator-compound-a
#11
Lukas D Landegger, Clemens Honeder, Chengjing Zhu, Hanna Schöpper, Elisabeth Engleder, Franz Gabor, Wolfgang Gstoettner, Christoph Arnoldner
BACKGROUND: Selective glucocorticoid receptor modulators (SEGRMs) comprise a novel class of drugs promising both reduced side effects and similar pharmacological potency relative to glucocorticoids, which presently serve as the only clinical treatment for many otologic disorders. In the first otologic SEGRM experiment in an animal model of noise trauma, we compare the effects of Compound A (a SEGRM) and dexamethasone (potent glucocorticoid). METHODS: Forty adult guinea pigs received experimental treatment once daily for ten days...
2016: Journal of Negative Results in Biomedicine
https://www.readbyqxmd.com/read/27133202/intracerebroventricular-injections-of-dronabinol-a-cannabinoid-receptor-agonist-does-not-attenuate-serotonin-induced-apnea-in-sprague-dawley-rats
#12
Michael W Calik, David W Carley
BACKGROUND: Evidence suggests that vagal nerve activity may play a role in sleep apnea induction. In anesthetized rats, dronabinol, a cannabinoid (CB) receptor agonist, injected into the nodose ganglia attenuates reflex apnea and increases genioglossus activity, and reflex apnea attenuation is blocked by systemic pre-treatment with cannabinoid type 1 and/or type 2 receptor antagonists. However, it is unclear whether dronabinol has similar effects in the central nervous system; CB receptors are widely distributed in the brain, especially on neuronal circuitry important for respiration and upper airway activation...
2016: Journal of Negative Results in Biomedicine
https://www.readbyqxmd.com/read/27109115/tlr2-deficiency-does-not-limit-the-development-of-left-ventricular-hypertrophy-in-a-model-of-transverse-aortic-constriction-induced-pressure-overload
#13
Tippaporn Bualeong, Sied Kebir, Dorothea Hof, Lina Goelz, Mathias Graewe, Stefan Felix Ehrentraut, Pascal Knuefermann, Georg Baumgarten, Rainer Meyer, Heidi Ehrentraut
BACKGROUND: Toll-like receptors (TLRs) are involved in a variety of cardiovascular disorders, including septic cardiomyopathy, ischemia/reperfusion, heart failure, and cardiac hypertrophy. Previous research revealed that TLR4 promotes cardiac hypertrophy in vivo. Therefore, we investigated whether TLR2 is also involved in the development of cardiac hypertrophy. METHODS: Tlr2 deficient and wild type mice were subjected to transverse aortic constriction (TAC) or sham operation procedure...
2016: Journal of Negative Results in Biomedicine
https://www.readbyqxmd.com/read/27063005/endothelial-platelet-and-macrophage-microparticle-levels-do-not-change-acutely-following-transcatheter-aortic-valve-replacement
#14
Julio F Marchini, Ayumi Aurea Miyakawa, Flavio Tarasoutchi, José Eduardo Krieger, Pedro Lemos, Kevin Croce
BACKGROUND: Patients with severe aortic stenosis have increased levels of prothrombotic and proinflammatory microparticles (MP), and MPs actively regulate pathological processes that lead to atherothrombotic cardiovascular events. Shear stress is a validated stimulus of MP production, and abnormal shear stress in aortic stenosis increases MP release in ex-vivo studies. We hypothesized that in patients with severe aortic stenosis, percutaneous replacement of the aortic valve (TAVR) would reduce abnormal shear stress and would decrease levels of circulating MPs...
2016: Journal of Negative Results in Biomedicine
https://www.readbyqxmd.com/read/27036549/targeted-drugs-and-psycho-oncological-intervention-for-breast-cancer-patients
#15
REVIEW
Flavio D'Abramo, Ute Goerling, Cecilia Guastadisegni
Personalized medicine is a new field based on molecular biology and genomics in which targeted tumor therapies are administered to patients. Psycho-oncology is a complementary approach that considers social and psychological aspects of patients as part of the treatments for cancer patients. The aim of this mini-review is to weigh clinical benefits for breast cancer patients of both treatments and possibly enhance benefits by modulating the use of both interventions. We have compared and evaluated on the one hand the use of anti Vascular Endothelial Growth Factor and, on the other hand, psycho-oncological interventions in metastatic and non-metastatic breast cancer patients...
2016: Journal of Negative Results in Biomedicine
https://www.readbyqxmd.com/read/26971048/topical-ocular-dexamethasone-decreases-intraocular-pressure-and-body-weight-in-rats
#16
Kota Sato, Koji M Nishiguchi, Kazuichi Maruyama, Satoru Moritoh, Kosuke Fujita, Yoshikazu Ikuta, Hitoshi Kasai, Toru Nakazawa
BACKGROUND: Recently, topical dexamethasone-induced ocular hypertension and a consequent loss of retinal ganglion cells (RGCs) have been described in mice. This has been proposed as a model of steroid-induced glaucoma. In this study, we set up and evaluated a similar model in rats. RESULTS: Ten-week old Sprague Dawley (SD) rats (N = 12) were used to evaluate the effect of topical 0.1% dexamethasone (50 μl) administered 3 times daily for 4 weeks. Sodium chloride (0...
2016: Journal of Negative Results in Biomedicine
https://www.readbyqxmd.com/read/26932735/comparison-of-serological-methods-with-pcr-based-methods-for-the-diagnosis-of-community-acquired-pneumonia-caused-by-atypical-bacteria
#17
Mariana Herrera, Yudy Alexandra Aguilar, Zulma Vanessa Rueda, Carlos Muskus, Lázaro Agustín Vélez
BACKGROUND: The diagnosis of community-acquired pneumonia (CAP) caused by Legionella pneumophila, Mycoplasma pneumoniae, and Chlamydophila pneumoniae is traditionally based on cultures and serology, which have special requirements, are time-consuming, and offer delayed results that limit their clinical usefulness of these techniques. We sought to develop a multiplex PCR (mPCR) method to diagnosis these bacterial infections in CAP patients and to compare the diagnostic yields obtained from mPCR of nasopharyngeal aspirates (NPAs), nasopharyngeal swabs (NPSs), and induced sputum (IS) with those obtained with specific PCR commercial kits, paired serology, and urinary antigen...
2016: Journal of Negative Results in Biomedicine
https://www.readbyqxmd.com/read/26887437/thanks-to-all-those-who-reviewed-for-journal-of-negative-results-in-biomedicine-in-2015
#18
Bjorn R Olsen, Dirk Mielenz
A peer-reviewed journal would not survive without the generous time and insightful comments of the reviewers, whose efforts often go unrecognized. Although final decisions are always editorial, they are greatly facilitated by the deeper technical knowledge, scientific insights, understanding of social consequences, and passion that reviewers bring to our deliberations. For these reasons, the Editor-in-Chief, Managing Editor and staff of Journal of Negative Results in BioMedicine warmly thank the 51 reviewers whose comments helped to shape the journal, for their invaluable assistance with review of manuscripts in Volume 14 (2015)...
2016: Journal of Negative Results in Biomedicine
https://www.readbyqxmd.com/read/26832747/use-of-diuretics-is-not-associated-with-mortality-in-patients-admitted-to-the-emergency-department-results-from-a-cross-sectional-study
#19
Dominik G Haider, Gregor Lindner, Michael Wolzt, Alexander Benedikt Leichtle, Georg-Martin Fiedler, Thomas C Sauter, Valentin Fuhrmann, Aristomenis K Exadaktylos
BACKGROUND: Patients with diuretic therapy are at risk for drug-induced adverse reactions. It is unknown if presence of diuretic therapy at hospital emergency room admission is associated with mortality. METHODS: In this cross sectional analysis, all emergency room patients 2010 and 2011 at the Inselspital Bern, Switzerland were included. A multivariable logistic regression model was performed to assess the association between pre-existing diuretic medication and 28 day mortality...
2016: Journal of Negative Results in Biomedicine
https://www.readbyqxmd.com/read/26627643/ethanol-exposure-during-the-third-trimester-equivalent-does-not-affect-gabaa-or-ampa-receptor-mediated-spontaneous-synaptic-transmission-in-rat-ca3-pyramidal-neurons
#20
Brian Charles Baculis, Carlos Fernando Valenzuela
BACKGROUND: Ethanol exposure during the rodent equivalent to the 3(rd) trimester of human pregnancy (i.e., first 1-2 weeks of neonatal life) has been shown to produce structural and functional alterations in the CA3 hippocampal sub-region, which is involved in associative memory. Synaptic plasticity mechanisms dependent on retrograde release of brain-derived neurotrophic factor (BDNF) driven by activation of L-type voltage-gated Ca(2+) channels (L-VGCCs) are thought to play a role in stabilization of both GABAergic and glutamatergic synapses in CA3 pyramidal neurons...
December 2, 2015: Journal of Negative Results in Biomedicine
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