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Journal of Negative Results in Biomedicine

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https://www.readbyqxmd.com/read/28316284/facial-cutaneo-mucosal-venous-malformations-can-develop-independently-of-mutation-of-tek-gene-%C3%AF-but-may-be-associated-with-excessive-expression-of-src-and-p-src
#1
Nabila Brahami, Selvakumar Subramaniam, Moudjahed Saleh Al-Ddafari, Cecile Elkaim, Pierre-Olivier Harmand, Badr-Eddine Sari, Gérard Lefranc, Mourad Aribi
We aimed to search for mutations in the germline and somatic DNA of the TEK gene and to analyze the expression level of Src and phospho-Src (p-Src) in tumor and healthy tissues from patients with facial cutaneo-mucosal venous malformations (VMCM). Eligible patients from twelve families and thirty healthy controls were recruited respectively at the Departments of Stomatology and Oral Surgery, and Transfusion Medicine of Tlemcen University Medical Centre. Immunoblot analyses of Src and p-Src were performed after direct DNA sequencing...
March 20, 2017: Journal of Negative Results in Biomedicine
https://www.readbyqxmd.com/read/28285600/experimental-silicosis-does-not-aggravate-collagen-induced-arthritis-in-mice
#2
Robby Engelmann, Brigitte Müller-Hilke
OBJECTIVES: To investigate the effect of chronic lung inflammation on the incidence and severity of collagen-induced arthritis in mice. METHODS: Chronic lung inflammation in the form of silicosis was induced via intranasal application of silica particles. Immunization with collagen Type II commenced one week later and mice were sacrificed six weeks after booster immunization. Thereafter, silicosis was confirmed via flow cytometry and arthritis was evaluated performing knee and paw histology...
March 13, 2017: Journal of Negative Results in Biomedicine
https://www.readbyqxmd.com/read/28274242/erratum-to-do-anti-amyloid-beta-protein-antibody-cross-reactivities-confound-alzheimer-disease-research
#3
Sally Hunter, Carol Brayne
No abstract text is available yet for this article.
March 8, 2017: Journal of Negative Results in Biomedicine
https://www.readbyqxmd.com/read/28245857/the-diagnostic-value-of-the-bronchoalveolar-lavage-in-interstitial-lung-diseases
#4
Boubacar Efared, G Ebang-Atsame, Sani Rabiou, Abdoulsalam S Diarra, Layla Tahiri, Nawal Hammas, Mohamed Smahi, Bouchra Amara, Mohamed C Benjelloun, Mounia Serraj, Laila Chbani, Hinde El Fatemi
OBJECTIVE: Bronchoalveolar lavage (BAL) is a diagnostic tool often used during the management of interstitial lung diseases (ILD). However, its diagnostic value in discrimination between entities comprising the very heterogenous group of ILD, is still a controversial issue. The objective of our study is to assess the diagnostic value of BAL in the management of ILD, by comparing the cytological findings in BAL fluid among the different diseases of this group. METHODS: It was a retrospective, observational study of 151 patients between January 2012 and December 2015...
March 1, 2017: Journal of Negative Results in Biomedicine
https://www.readbyqxmd.com/read/28214466/antimicrobial-activity-of-hl-60-cells-compared-to-primary-blood-derived-neutrophils-against-staphylococcus-aureus
#5
Ragheda Yaseen, Stefanie Blodkamp, Petra Lüthje, Friederike Reuner, Lena Völlger, Hassan Y Naim, Maren von Köckritz-Blickwede
BACKGROUND: The human leukemia cell line HL-60 is considered an alternative cell culture model to study neutrophil differentiation and migration. The aim of this study was to characterize the suitability of HL-60 cells differentiated to neutrophil-like cells (nHL-60) as substitute for blood-derived human neutrophils to investigate the interaction of neutrophils with Staphylococcus aureus. METHODS: For this purpose, antimicrobial activity, bacterial uptake, production of reactive oxygen species and the release of neutrophil extracellular traps (NETs) by nHL-60 cells were analyzed and compared to primary blood-derived neutrophils using Staphylococcus aureus as important human and animal pathogen...
February 19, 2017: Journal of Negative Results in Biomedicine
https://www.readbyqxmd.com/read/28153016/lack-of-association-between-polymorphism-rs540782-and-primary-open-angle-glaucoma-in-saudi-patients
#6
Altaf A Kondkar, Nikhil B Edward, Hatem Kalantan, Abdullah S Al-Kharashi, Saleh Altuwaijri, Gamal Mohamed, Tahira Sultan, Taif A Azad, Khaled K Abu-Amero
BACKGROUND: To investigate whether polymorphism rs540782 on chromsome 1, in close proximity to the Zona Pellucida Glycoprotein 4 (ZP4) gene, is a risk factor for primary open angle glaucoma (POAG). METHOD: The study genotyped 92 unrelated POAG cases and 95 control subjects from Saudi Arabia using Taq-Man® assay. RESULTS: The genotype frequency distribution did not deviate significantly from the Hardy-Weinberg equilibrium (p > 0.05)...
February 2, 2017: Journal of Negative Results in Biomedicine
https://www.readbyqxmd.com/read/28126004/do-anti-amyloid-beta-protein-antibody-cross-reactivities-confound-alzheimer-disease-research
#7
REVIEW
Sally Hunter, Carol Brayne
BACKGROUND: Alzheimer disease (AD) research has focussed mainly on the amyloid beta protein (Aβ). However, many Aβ-and P3-type peptides derived from the amyloid precursor protein (APP) and peptides thought to derive from Aβ catabolism share sequence homology. Additionally, conformations can change dependent on aggregation state and solubility leading to significant uncertainty relating to interpretations of immunoreactivity with antibodies raised against Aβ. We review evidence relating to the reactivities of commonly used antibodies including 6F3D, 6E10 and 4G8 and evaluate their reactivity profiles with respect to AD diagnosis and research...
January 26, 2017: Journal of Negative Results in Biomedicine
https://www.readbyqxmd.com/read/27978824/unspecific-binding-of-crna-probe-to-plaques-in-two-mouse-models-for-alzheimer-s-disease
#8
Anne Schaarschuch, Christoph Redies, Nicole Hertel
BACKGROUND: Alzheimer's disease (AD) is characterized by the pathological deposition of amyloid-β (Aβ) protein-containing plaques. Microglia and astrocytes are commonly attracted to the plaques by an unknown mechanism that may involve cell adhesion. One cell adhesion family of proteins, the cadherins, are widely expressed in the central nervous system. Therefore, our study was designed to map the expression of cadherins in AD mouse brains. A particular focus was on plaques because diverse mRNA-species were found in plaques and their surrounding area in brains of AD patients...
December 16, 2016: Journal of Negative Results in Biomedicine
https://www.readbyqxmd.com/read/27938391/false-data-positive-results-in-neurobiology-moving-beyond-the-epigenetics-of-blood-and-saliva-samples-in-mental-disorders
#9
EDITORIAL
A Cariaga-Martinez, R Alelú-Paz
Many psychiatric diseases are influenced by a set of several genetic and environmental factors that genetics alone cannot explain. Specifically, in schizophrenia and bipolar disorder the absence of consistently replicated genetic effects together with evidence for lasting changes in gene expression after environmental exposures suggest a role of epigenetic mechanisms in its pathophysiological mechanisms. In this field, the presence of positive results could potentially uncover molecular mechanisms of deregulated gene expression in these complex disorders...
December 12, 2016: Journal of Negative Results in Biomedicine
https://www.readbyqxmd.com/read/27916002/long-term-effect-of-stents-eluting-6-mercaptopurine-in-porcine-coronary-arteries
#10
Matthijs S Ruiter, Albert Doornbos, Vivian de Waard, Robbert J de Winter, Nico J M Attevelt, Rob Steendam, Carlie J M de Vries
BACKGROUND: Drug-eluting stents (DES) have dramatically reduced restenosis rates compared to bare metal stents and are widely used in coronary artery angioplasty. The anti-proliferative nature of the drugs reduces smooth muscle cell (SMC) proliferation effectively, but unfortunately also negatively affects endothelialization of stent struts, necessitating prolonged dual anti-platelet therapy. Cell-type specific therapy may prevent this complication, giving rise to safer stents that do not require additional medication...
December 5, 2016: Journal of Negative Results in Biomedicine
https://www.readbyqxmd.com/read/27802801/examining-if-being-overweight-really-confers-protection-against-dementia-sixty-four-year-follow-up-of-participants-in-the-glasgow-university-alumni-cohort-study
#11
G David Batty, Bruna Galobardes, John M Starr, Mona Jeffreys, George Davey Smith, Tom C Russ
BACKGROUND: Recent large-scale studies suggest that obesity and overweight may confer protection against future dementia. This observation could, however, be generated by reverse causality. That is, weight loss in the incipient phase of dementia ascribed to diminished self-care, including sub-optimal nutrition, would have the effect of generating such an inverse association. One approach to circumventing this problem would be to measure weight in a population which is young enough to be free of the symptoms of dementia which is then followed up for dementia occurrence over many decades...
November 2, 2016: Journal of Negative Results in Biomedicine
https://www.readbyqxmd.com/read/27784318/dietary-phosphate-supplement-does-not-rescue-skeletal-phenotype-in-a-mouse-model-for-craniometaphyseal-dysplasia
#12
Yaling Liu, Eliane H Dutra, Ernst J Reichenberger, I-Ping Chen
BACKGROUND: Mutations in the human progressive ankylosis gene (ANKH; Mus musculus ortholog Ank) have been identified as cause for craniometaphyseal dysplasia (CMD), characterized by progressive thickening of craniofacial bones and flared metaphyses of long bones. We previously reported a knock-in (KI) mouse model (Ank (KI/KI)) for CMD and showed transiently lower serum phosphate (Pi) as well as significantly higher mRNA levels of fibroblast growth factor 23 (Fgf23) in Ank (KI/KI) mice...
October 26, 2016: Journal of Negative Results in Biomedicine
https://www.readbyqxmd.com/read/27687253/polymorphism-rs7555523-in-transmembrane-and-coiled-coil-domain-1-tmco1-is-not-a-risk-factor-for-primary-open-angle-glaucoma-in-a-saudi-cohort
#13
Altaf A Kondkar, Ahmed Mousa, Taif A Azad, Tahira Sultan, Abdullah Alawad, Saleh Altuwaijri, Saleh A Al-Obeidan, Khaled K Abu-Amero
BACKGROUND: We investigated whether polymorphism rs7555523 (A > C) in human transmembrane and coiled-coil domain 1 (TMCO1) gene is a risk factor for primary open angle glaucoma (POAG) in a Saudi cohort. METHODS: A cohort of 87 unrelated POAG cases and 94 control subjects from Saudi Arabia were genotyped using Taq-Man® assay. The association of genotypes with POAG and other glaucoma specific clinical indices was investigated. RESULTS: The genotype and allele frequency of polymorphism rs7555523 at TMCO1 did not show any statistically significant association with POAG as compared to controls...
September 29, 2016: Journal of Negative Results in Biomedicine
https://www.readbyqxmd.com/read/27582019/low-density-lipoprotein-receptor-related-protein-5-gene-polymorphisms-and-osteoporosis-in-thai-menopausal-women
#14
Anong Kitjaroentham, Hathairad Hananantachai, Benjaluck Phonrat, Sangchai Preutthipan, Rungsunn Tungtrongchitr
BACKGROUND: Osteoporosis, characterized by low bone mineral density (BMD) and high bone fracture risk, is prevalent in Thai menopausal women. Genetic factors are known to play a key role in BMD. Low density lipoprotein receptor-related protein 5 (LRP5), a co-receptor in the Wnt/beta-catenin pathway, is involved in many aspects of bone biology. As coding single nucleotide polymorphisms (cSNPs) of LRP5, including A1330V (rs3736228), and Asian-related Q89R (rs41494349) and N740N (rs2306862), are associated with lowered BMD, this study aimed to determine the relationship between these LRP5 polymorphisms and BMD in 277 Thai menopausal women...
September 1, 2016: Journal of Negative Results in Biomedicine
https://www.readbyqxmd.com/read/27553084/evaluation-of-a-novel-virtual-screening-strategy-using-receptor-decoy-binding-sites
#15
Hershna Patel, Andreas Kukol
Virtual screening is used in biomedical research to predict the binding affinity of a large set of small organic molecules to protein receptor targets. This report shows the development and evaluation of a novel yet straightforward attempt to improve this ranking in receptor-based molecular docking using a receptor-decoy strategy. This strategy includes defining a decoy binding site on the receptor and adjusting the ranking of the true binding-site virtual screen based on the decoy-site screen. The results show that by docking against a receptor-decoy site with Autodock Vina, improved Receiver Operator Characteristic Enrichment (ROCE) was achieved for 5 out of fifteen receptor targets investigated, when up to 15 % of a decoy site rank list was considered...
August 23, 2016: Journal of Negative Results in Biomedicine
https://www.readbyqxmd.com/read/27452910/gastrokine-1-mrna-in-human-sera-is-not-informative-biomarker-for-gastric-cancer
#16
Valentina Villano, Chiara Stella Di Stadio, Antonella Federico, Filomena Altieri, Giuseppina Miselli, Maurizio De Palma, Emilia Rippa, Paolo Arcari
BACKGROUND: We aimed to ascertain if Gastrokine 1 mRNA in the sera of patients with gastric cancer might be an informative biomarker for the disease. RESULTS: Analysis of GKN1 mRNA in serum samples from healthy individuals (n = 23) and from patients with diagnosis of gastric cancer (n = 16), performed by using absolute quantification based on standard curve method, did not show any significative statistical difference between the two unpaired group of individuals...
July 25, 2016: Journal of Negative Results in Biomedicine
https://www.readbyqxmd.com/read/27435165/is-mindfulness-protective-against-ptsd-a-neurocognitive-study-of-25-tsunami-disaster-survivors
#17
Christina Hagen, Lars Lien, Edvard Hauff, Trond Heir
BACKGROUND: It has been suggested that mindfulness is a protective factor that buffers individuals from experiencing severe posttraumatic stress following exposure to a trauma. We aimed to examine the association between dispositional (trait) mindfulness and posttraumatic stress in individuals who had been exposed to the trauma of a natural disaster. METHOD: A disaster group (n = 25) consisting of Norwegian tourists who survived the 2004 South East Asian tsunami at a location with high mortality rates was recruited...
July 20, 2016: Journal of Negative Results in Biomedicine
https://www.readbyqxmd.com/read/27401915/age-is-not-associated-with-intracranial-haemorrhage-in-patients-with-mild-traumatic-brain-injury-and-oral-anticoagulation
#18
Thomas C Sauter, Stephan Ziegenhorn, Sufian S Ahmad, Wolf E Hautz, Meret E Ricklin, Alexander Benedikt Leichtle, Georg-Martin Fiedler, Dominik G Haider, Aristomenis K Exadaktylos
BACKGROUND: Patients admitted to emergency departments with traumatic brain injury (TBI) are commonly being treated with oral anticoagulants. In contrast to patients without anticoagulant medication, no guidelines, scores or recommendations exist for the management of mild traumatic brain injury in these patients. We therefore tested whether age as one of the high risk factors of the Canadian head CT rule is applicable to a patient population on oral anticoagulants. METHODS: This cross-sectional analysis included all patients with mild TBI and concomitant oral anticoagulant therapy admitted to the Emergency Department, Inselspital Bern, Switzerland, from November 2009 to October 2014 (n = 200)...
June 1, 2016: Journal of Negative Results in Biomedicine
https://www.readbyqxmd.com/read/27211793/investigation-of-sla4a3-as-a-candidate-gene-for-human-retinal-disease
#19
Louise M Downs, Andrew R Webster, Anthony T Moore, Michel Michaelides, Robin R Ali, Alison J Hardcastle, Cathryn S Mellersh
SLC4A3 has been shown to cause retinal degeneration in a genetically engineered knockout mouse, and in a naturally occurring form of canine progressive retinal atrophy considered to be the equivalent of retinitis pigmentosa in humans (RP). This study was undertaken to investigate if SLC4A3 coding variants were implicated in human retinal degeneration. SLC4A3 exons were amplified and sequenced in 200 patients with autosomal recessive retinal degeneration who had no known molecular diagnosis for their condition, which included 197 unrelated individuals with suspected RP and three individuals with other forms of retinal disease...
May 23, 2016: Journal of Negative Results in Biomedicine
https://www.readbyqxmd.com/read/27164957/noise-trauma-and-systemic-application-of-the-selective-glucocorticoid-receptor-modulator-compound-a
#20
Lukas D Landegger, Clemens Honeder, Chengjing Zhu, Hanna Schöpper, Elisabeth Engleder, Franz Gabor, Wolfgang Gstoettner, Christoph Arnoldner
BACKGROUND: Selective glucocorticoid receptor modulators (SEGRMs) comprise a novel class of drugs promising both reduced side effects and similar pharmacological potency relative to glucocorticoids, which presently serve as the only clinical treatment for many otologic disorders. In the first otologic SEGRM experiment in an animal model of noise trauma, we compare the effects of Compound A (a SEGRM) and dexamethasone (potent glucocorticoid). METHODS: Forty adult guinea pigs received experimental treatment once daily for ten days...
May 11, 2016: Journal of Negative Results in Biomedicine
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