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Journal of Nanobiotechnology

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https://www.readbyqxmd.com/read/29137640/direct-reprogramming-of-mouse-fibroblasts-into-neural-cells-via-porphyra-yezoensis-polysaccharide-based-high-efficient-gene-co-delivery
#1
Qingtong Yu, Jingjing Chen, Wenwen Deng, Xia Cao, Yan Wang, Jie Zhou, Wenqian Xu, Pan Du, Qiang Wang, Jiangnan Yu, Ximing Xu
BACKGROUND: The cell source for transplantation therapy is always a prerequisite question to be solved in clinical applications. Neural cells are considered non-regenerable, which highly restrict their application in the treatment for nerve injury. Therefore, neural trans-differentiation based on gene transfection provides a new solution to this issue. Compared to viral strategy, non-viral gene delivery systems are considered as a more promising way to achieve this aim. This study centers on a novel application of Porphyra yezoensis polysaccharide as a non-viral gene carrier for the neural trans-differentiation of mouse fibroblasts...
November 14, 2017: Journal of Nanobiotechnology
https://www.readbyqxmd.com/read/29132385/aptamer-selection-and-applications-for-breast-cancer-diagnostics-and-therapy
#2
REVIEW
Mei Liu, Xiaocheng Yu, Zhu Chen, Tong Yang, Dandan Yang, Qianqian Liu, Keke Du, Bo Li, Zhifei Wang, Song Li, Yan Deng, Nongyue He
Aptamers are short non-coding, single-stranded oligonucleotides (RNA or DNA) developed through Systematic Evolution of Ligands by Exponential enrichment (SELEX) in vitro. Similar to antibodies, aptamers can bind to specific targets with high affinity, and are considered promising therapeutic agents as they have several advantages over antibodies, including high specificity, stability, and non-immunogenicity. Furthermore, aptamers can be produced at a low cost and easily modified, and are, therefore, called "chemical antibodies"...
November 13, 2017: Journal of Nanobiotechnology
https://www.readbyqxmd.com/read/29126419/the-adverse-vascular-effects-of-multi-walled-carbon-nanotubes-mwcnts-to-human-vein-endothelial-cells-huvecs-in-vitro-role-of-length-of-mwcnts
#3
Jimin Long, Yafang Xiao, Liangliang Liu, Yi Cao
BACKGROUND: Increasing evidences indicate that exposure to multi-walled carbon nanotubes (MWCNTs) could induce adverse vascular effects, but the role of length of MWCNTs in determining the toxic effects is less studied. This study investigated the adverse effects of two well-characterized MWCNTs to human umbilical vein endothelial cells (HUVECs). METHODS: The internalization and localization of MWCNTs in HUVECs were examined by using transmission electron microscopy (TEM)...
November 10, 2017: Journal of Nanobiotechnology
https://www.readbyqxmd.com/read/29121949/quantifying-engineered-nanomaterial-toxicity-comparison-of-common-cytotoxicity-and-gene-expression-measurements
#4
Donald H Atha, Amber Nagy, Andrea Steinbrück, Allison M Dennis, Jennifer A Hollingsworth, Varsha Dua, Rashi Iyer, Bryant C Nelson
BACKGROUND: When evaluating the toxicity of engineered nanomaterials (ENMS) it is important to use multiple bioassays based on different mechanisms of action. In this regard we evaluated the use of gene expression and common cytotoxicity measurements using as test materials, two selected nanoparticles with known differences in toxicity, 5 nm mercaptoundecanoic acid (MUA)-capped InP and CdSe quantum dots (QDs). We tested the effects of these QDs at concentrations ranging from 0.5 to 160 µg/mL on cultured normal human bronchial epithelial (NHBE) cells using four common cytotoxicity assays: the dichlorofluorescein assay for reactive oxygen species (ROS), the lactate dehydrogenase assay for membrane viability (LDH), the mitochondrial dehydrogenase assay for mitochondrial function, and the Comet assay for DNA strand breaks...
November 9, 2017: Journal of Nanobiotechnology
https://www.readbyqxmd.com/read/29121930/buckyballs-conjugated-with-nucleic-acid-sequences-identifies-microorganisms-in-live-cell-assays
#5
Qingsu Cheng, Bahram Parvin
BACKGROUND: Rapid identification of bacteria can play an important role at the point of care, evaluating the health of the ecosystem, and discovering spatiotemporal distributions of a bacterial community. We introduce a method for rapid identification of bacteria in live cell assays based on cargo delivery of a nucleic acid sequence and demonstrate how a mixed culture can be differentiated using a simple microfluidic system. METHODS: C60 Buckyballs are functionalized with nucleic acid sequences and a fluorescent reporter to show that a diversity of microorganisms can be detected and identified in live cell assays...
November 9, 2017: Journal of Nanobiotechnology
https://www.readbyqxmd.com/read/29100510/antimicrobial-effects-of-zero-valent-iron-nanoparticles-on-gram-positive-bacillus-strains-and-gram-negative-escherichia-coli-strains
#6
Yi-Huang Hsueh, Ping-Han Tsai, Kuen-Song Lin, Wan-Ju Ke, Chao-Lung Chiang
BACKGROUND: Zero-valent iron nanoparticles (ZVI NPs) have been used extensively for the remediation of contaminated soil and groundwater. Owing to their large active surface area, they serve as strong and effective reductants. However, the ecotoxicity and bioavailability of ZVI NPs in diverse ecological media have not been evaluated in detail and most studies have focused on non-nano ZVI or Fe(0). In addition, the antimicrobial properties of ZVI NPs have rarely been investigated, and the underlying mechanism of their toxicity remains unknown...
November 3, 2017: Journal of Nanobiotechnology
https://www.readbyqxmd.com/read/29078797/dual-stimuli-responsive-fe3o4-graft-poly-acrylic-acid-block-poly-2-methacryloyloxyethyl-ferrocenecarboxylate-copolymer-micromicelles-surface-raft-synthesis-self-assembly-and-drug-release-applications
#7
Yuan Wang, Xue-Yin Zhang, Yan-Ling Luo, Feng Xu, Ya-Shao Chen, Yu-Yu Su
BACKGROUND: Stimuli-responsive polymer materials are a new kind of intelligent materials based on the concept of bionics, which exhibits more significant changes in physicochemical properties upon triggered by tiny environment stimuli, hence providing a good carrier platform for antitumor drug delivery. RESULTS: Dual stimuli-responsive Fe3O4 graft poly(acrylic acid)-block-poly(2-methacryloyloxyethyl ferrocenecarboxylate) block copolymers (Fe3O4-g-PAA-b-PMAEFC) were engineered and synthesized through a two-step sequential reversible addition-fragmentation chain transfer polymerization route...
October 27, 2017: Journal of Nanobiotechnology
https://www.readbyqxmd.com/read/29065876/nanomaterials-modulate-stem-cell-differentiation-biological-interaction-and-underlying-mechanisms
#8
REVIEW
Min Wei, Song Li, Weidong Le
Stem cells are unspecialized cells that have the potential for self-renewal and differentiation into more specialized cell types. The chemical and physical properties of surrounding microenvironment contribute to the growth and differentiation of stem cells and consequently play crucial roles in the regulation of stem cells' fate. Nanomaterials hold great promise in biological and biomedical fields owing to their unique properties, such as controllable particle size, facile synthesis, large surface-to-volume ratio, tunable surface chemistry, and biocompatibility...
October 25, 2017: Journal of Nanobiotechnology
https://www.readbyqxmd.com/read/29041937/biocompatible-coated-magnetosome-minerals-with-various-organization-and-cellular-interaction-properties-induce-cytotoxicity-towards-rg-2-and-gl-261-glioma-cells-in-the-presence-of-an-alternating-magnetic-field
#9
Yasmina Hamdous, Imène Chebbi, Chalani Mandawala, Raphael Le Fèvre, François Guyot, Olivier Seksek, Edouard Alphandéry
BACKGROUND: Biologics magnetics nanoparticles, magnetosomes, attract attention because of their magnetic characteristics and potential applications. The aim of the present study was to develop and characterize novel magnetosomes, which were extracted from magnetotactic bacteria, purified to produce apyrogen magnetosome minerals, and then coated with Chitosan, Neridronate, or Polyethyleneimine. It yielded stable magnetosomes designated as M-Chi, M-Neri, and M-PEI, respectively. Nanoparticle biocompatibility was evaluated on mouse fibroblast cells (3T3), mouse glioblastoma cells (GL-261) and rat glioblastoma cells (RG-2)...
October 17, 2017: Journal of Nanobiotechnology
https://www.readbyqxmd.com/read/29017600/ions-doped-melanin-nanoparticle-as-a-multiple-imaging-agent
#10
Shin-Woo Ha, Hee-Sang Cho, Young Il Yoon, Moon-Sun Jang, Kwan Soo Hong, Emmanuel Hui, Jung Hee Lee, Tae-Jong Yoon
BACKGROUND: Multimodal nanomaterials are useful for providing enhanced diagnostic information simultaneously for a variety of in vivo imaging methods. According to our research findings, these multimodal nanomaterials offer promising applications for cancer therapy. RESULTS: Melanin nanoparticles can be used as a platform imaging material and they can be simply produced by complexation with various imaging active ions. They are capable of specifically targeting epidermal growth factor receptor (EGFR)-expressing cancer cells by being anchored with a specific antibody...
October 10, 2017: Journal of Nanobiotechnology
https://www.readbyqxmd.com/read/29017510/synthesis-of-europium-doped-vsop-customized-enhancer-solution-and-improved-microscopy-fluorescence-methodology-for-unambiguous-histological-detection
#11
Angela Ariza de Schellenberger, Ralf Hauptmann, Jason M Millward, Eyk Schellenberger, Yuske Kobayashi, Matthias Taupitz, Carmen Infante-Duarte, Jörg Schnorr, Susanne Wagner
BACKGROUND: Intrinsic iron in biological tissues frequently precludes unambiguous the identification of iron oxide nanoparticles when iron-based detection methods are used. Here we report the full methodology for synthesizing very small iron oxide nanoparticles (VSOP) doped with europium (Eu) in their iron oxide core (Eu-VSOP) and their unambiguous qualitative and quantitative detection by fluorescence. METHODS AND RESULTS: The resulting Eu-VSOP contained 0.7 to 2...
October 10, 2017: Journal of Nanobiotechnology
https://www.readbyqxmd.com/read/29017502/the-presence-of-residual-gold-nanoparticles-in-samples-interferes-with-the-rt-qpcr-assay-used-for-gene-expression-profiling
#12
Natasha M Sanabria, Mary Gulumian
BACKGROUND: RT-qPCR is routinely used in expression profiling of toxicity pathway genes. However, genetic and molecular level studies used to determine, understand and clarify potential risks of engineered nanomaterials (ENMs) are still incomplete. Concerns regarding possible interference caused by intracellular ENMs during analyses have been raised. The aim of this study was to verify a qPCR procedure for gene expression assays, which can be used in toxicity and exposure assessments...
October 10, 2017: Journal of Nanobiotechnology
https://www.readbyqxmd.com/read/28985740/nanoscale-click-reactive-scaffolds-from-peptide-self-assembly
#13
Alexander P M Guttenplan, Laurence J Young, Dijana Matak-Vinkovic, Clemens F Kaminski, Tuomas P J Knowles, Laura S Itzhaki
BACKGROUND: Due to their natural tendency to self-assemble, proteins and peptides are important components for organic nanotechnology. One particular class of peptides of recent interest is those that form amyloid fibrils, as this self-assembly results in extremely strong, stable quasi-one-dimensional structures which can be used to organise a wide range of cargo species including proteins and oligonucleotides. However, assembly of peptides already conjugated to proteins is limited to cargo species that do not interfere sterically with the assembly process or misfold under the harsh conditions often used for assembly...
October 6, 2017: Journal of Nanobiotechnology
https://www.readbyqxmd.com/read/28982373/nanodiamond-enhances-immune-responses-in-mice-against-recombinant-ha-h7n9-protein
#14
Ngoc Bich Pham, Thuong Thi Ho, Giang Thu Nguyen, Thuy Thi Le, Ngoc Thu Le, Huan-Cheng Chang, Minh Dinh Pham, Udo Conrad, Ha Hoang Chu
BACKGROUND: The continuing spread of the newly emerged H7N9 virus among poultry in China, as well as the possibility of human-to-human transmission, has attracted numerous efforts to develop an effective vaccine against H7N9. The use of nanoparticles in vaccinology is inspired by the fact that most pathogens have a dimension within the nano-size range and therefore can be processed efficiently by the immune system, which leads to a potent immune response. Herein, we report a facile approach to increase antigen size to achieve not only fast but also effective responses against the recombinant HA/H7N9 protein via a simple conjugation of the protein onto the surface of nanodiamond particles...
October 5, 2017: Journal of Nanobiotechnology
https://www.readbyqxmd.com/read/28982368/fabrication-of-device-with-poly-n-isopropylacrylamide-b-ssdna-copolymer-brush-for-resistivity-study
#15
Yi-Zu Liu, May-Show Chen, Chih-Chia Cheng, Shih-Hsun Chen, Jem-Kun Chen
In this study, we grafted bromo-terminated poly(N-isopropylacrylamide) (PNIPAAm) brushes onto thin gold films deposited on silicon, and then reacted with NaN3 to produce azido-terminated PNIPAAm brushes. A probe sequence of single-stranded DNA (ssDNA) with a 4-pentynoic acid succinimidyl ester unit was grafted onto the azido-terminated PNIPAAm brushes through a click reaction, resulting in the formation of block copolymer brushes. The PNIPAAm-b-ssDNA copolymer brushes formed supramolecular complexes stabilized by bio-multiple hydrogen bonds (BMHBs), which enhanced the proton transfer and thereby decreased the resistivity of the structures...
October 5, 2017: Journal of Nanobiotechnology
https://www.readbyqxmd.com/read/28982361/distribution-of-plga-modified-nanoparticles-in-3d-cell-culture-models-of-hypo-vascularized-tumor-tissue
#16
Lee B Sims, Maya K Huss, Hermann B Frieboes, Jill M Steinbach-Rankins
BACKGROUND: Advanced stage cancer treatments are often invasive and painful-typically comprised of surgery, chemotherapy, and/or radiation treatment. Low transport efficiency during systemic chemotherapy may require high chemotherapeutic doses to effectively target cancerous tissue, resulting in systemic toxicity. Nanotherapeutic platforms have been proposed as an alternative to more safely and effectively deliver therapeutic agents directly to tumor sites. However, cellular internalization and tumor penetration are often diametrically opposed, with limited access to tumor regions distal from vasculature, due to irregular tissue morphologies...
October 5, 2017: Journal of Nanobiotechnology
https://www.readbyqxmd.com/read/28978341/mab-mdr1-modified-chitosan-nanoparticles-overcome-acquired-egfr-tki-resistance-through-two-potential-therapeutic-targets-modulation-of-mdr1-and-autophagy
#17
Yan Zheng, Chang Su, Liang Zhao, Yijie Shi
BACKGROUND: Tyrosine kinase inhibitors (TKIs) that act against the epithelial growth factor receptor (EGFR) were once widely used in chemotherapy for many human cancers. However, acquired chemoresistance occurred in almost all patients, limiting the clinical application of EGFR-TKI. Thus far, no effective methods existing can resolve this problem. Designing a therapeutic treatment with a specific multi-target profile has been regarded as a possible strategy to overcome acquired EGFR-TKI resistance...
October 4, 2017: Journal of Nanobiotechnology
https://www.readbyqxmd.com/read/28974225/metal-nanoparticles-understanding-the-mechanisms-behind-antibacterial-activity
#18
REVIEW
Yael N Slavin, Jason Asnis, Urs O Häfeli, Horacio Bach
As the field of nanomedicine emerges, there is a lag in research surrounding the topic of nanoparticle (NP) toxicity, particularly concerned with mechanisms of action. The continuous emergence of bacterial resistance has challenged the research community to develop novel antibiotic agents. Metal NPs are among the most promising of these because show strong antibacterial activity. This review summarizes and discusses proposed mechanisms of antibacterial action of different metal NPs. These mechanisms of bacterial killing include the production of reactive oxygen species, cation release, biomolecule damages, ATP depletion, and membrane interaction...
October 3, 2017: Journal of Nanobiotechnology
https://www.readbyqxmd.com/read/28969628/bio-mimicking-nano-and-micro-structured-surface-fabrication-for-antibacterial-properties-in-medical-implants
#19
REVIEW
Alka Jaggessar, Hesam Shahali, Asha Mathew, Prasad K D V Yarlagadda
Orthopaedic and dental implants have become a staple of the medical industry and with an ageing population and growing culture for active lifestyles, this trend is forecast to continue. In accordance with the increased demand for implants, failure rates, particularly those caused by bacterial infection, need to be reduced. The past two decades have led to developments in antibiotics and antibacterial coatings to reduce revision surgery and death rates caused by infection. The limited effectiveness of these approaches has spurred research into nano-textured surfaces, designed to mimic the bactericidal properties of some animal, plant and insect species, and their topographical features...
October 2, 2017: Journal of Nanobiotechnology
https://www.readbyqxmd.com/read/28962657/construction-of-ultrasonic-nanobubbles-carrying-caix-polypeptides-to-target-carcinoma-cells-derived-from-various-organs
#20
Lianhua Zhu, Yanli Guo, Luofu Wang, Xiaozhou Fan, Xingyu Xiong, Kejing Fang, Dan Xu
BACKGROUND: Ultrasound molecular imaging is a novel diagnostic approach for tumors, whose key link is the construction of targeted ultrasound contrast agents. However, available targeted ultrasound contrast agents for molecular imaging of tumors are only achieving imaging in blood pool or one type tumor. No targeted ultrasound contrast agents have realized targeted ultrasound molecular imaging of tumor parenchymal cells in a variety of solid tumors so far. Carbonic anhydrase IX (CAIX) is highly expressed on cell membranes of various malignant solid tumors, so it's a good target for ultrasound molecular imaging...
September 29, 2017: Journal of Nanobiotechnology
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