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Journal of Nanobiotechnology

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https://www.readbyqxmd.com/read/28743275/block-copolymer-conjugated-au-coated-fe3o4-nanoparticles-as-vectors-for-enhancing-colloidal-stability-and-cellular-uptake
#1
Junbo Li, Sheng Zou, Jiayu Gao, Ju Liang, Huiyun Zhou, Lijuan Liang, Wenlan Wu
BACKGROUND: Polymer surface-modified inorganic nanoparticles (NPs) provide a multifunctional platform for assisting gene delivery. Rational structure design for enhancing colloidal stability and cellular uptake is an important strategy in the development of safe and highly efficient gene vectors. RESULTS: Heterogeneous Au-coated Fe3O4 (Fe3O4@Au) NPs capped by polyethylene glycol-b-poly1-(3-aminopropyl)-3-(2-methacryloyloxy propylimidazolium bromine) (PEG-b-PAMPImB-Fe3O4@Au) were prepared for DNA loading and magnetofection assays...
July 25, 2017: Journal of Nanobiotechnology
https://www.readbyqxmd.com/read/28732539/enzyme-adsorption-induced-activity-changes-a-quantitative-study-on-tio2-model-agglomerates
#2
Augusto Márquez, Krisztina Kocsis, Gregor Zickler, Gilles R Bourret, Andrea Feinle, Nicola Hüsing, Martin Himly, Albert Duschl, Thomas Berger, Oliver Diwald
BACKGROUND: Activity retention upon enzyme adsorption on inorganic nanostructures depends on different system parameters such as structure and composition of the support, composition of the medium as well as enzyme loading. Qualitative and quantitative characterization work, which aims at an elucidation of the microscopic details governing enzymatic activity, requires well-defined model systems. RESULTS: Vapor phase-grown and thermally processed anatase TiO2 nanoparticle powders were transformed into aqueous particle dispersions and characterized by dynamic light scattering and laser Doppler electrophoresis...
July 21, 2017: Journal of Nanobiotechnology
https://www.readbyqxmd.com/read/28720097/a-versatile-papaya-mosaic-virus-papmv-vaccine-platform-based-on-sortase-mediated-antigen-coupling
#3
Ariane Thérien, Mikaël Bédard, Damien Carignan, Gervais Rioux, Louis Gauthier-Landry, Marie-Ève Laliberté-Gagné, Marilène Bolduc, Pierre Savard, Denis Leclerc
BACKGROUND: Flexuous rod-shaped nanoparticles made of the coat protein (CP) of papaya mosaic virus (PapMV) have been shown to trigger innate immunity through engagement of toll-like receptor 7 (TLR7). PapMV nanoparticles can also serve as a vaccine platform as they can increase the immune response to fused peptide antigens. Although this approach shows great potential, fusion of antigens directly to the CP open reading frame (ORF) is challenging because the fused peptides can alter the structure of the CP and its capacity to self assemble into nanoparticles-a property essential for triggering an efficient immune response to the peptide...
July 18, 2017: Journal of Nanobiotechnology
https://www.readbyqxmd.com/read/28716122/systematic-evaluation-of-oligodeoxynucleotide-binding-and-hybridization-to-modified-multi-walled-carbon-nanotubes
#4
Anika Kaufmann, Silke Hampel, Christiane Rieger, David Kunhardt, Darja Schendel, Susanne Füssel, Bernd Schwenzer, Kati Erdmann
BACKGROUND: In addition to conventional chemotherapeutics, nucleic acid-based therapeutics like antisense oligodeoxynucleotides (AS-ODN) represent a novel approach for the treatment of bladder cancer (BCa). An efficient delivery of AS-ODN to the urothelium and then into cancer cells might be achieved by the local application of multi-walled carbon nanotubes (MWCNT). In the present study, pristine MWCNT and MWCNT functionalized with hydrophilic moieties were synthesized and then investigated regarding their physicochemical characteristics, dispersibility, biocompatibility, cellular uptake and mucoadhesive properties...
July 17, 2017: Journal of Nanobiotechnology
https://www.readbyqxmd.com/read/28705169/antireflective-nanocoatings-for-uv-sensation-the-case-of-predatory-owlfly-insects
#5
LETTER
Mikhail Kryuchkov, Jannis Lehmann, Jakob Schaab, Manfred Fiebig, Vladimir L Katanaev
Moth-eye nanostructures, discovered to coat corneae of certain nocturnal insects, have inspired numerous technological applications to reduce light reflectance from solar cells, light-emitting diodes, and optical detectors. Technological developments require such nanocoatings to possess broadband antireflective properties, transcending the visual light spectrum, in which animals typically operate. Here we describe the corneal nanostructures of the visual organ exclusive in UV sensation of the hunting insect Libelloides macaronius and report their supreme anti-light-reflectance capacity...
July 14, 2017: Journal of Nanobiotechnology
https://www.readbyqxmd.com/read/28693576/cell-based-cytotoxicity-assays-for-engineered-nanomaterials-safety-screening-exposure-of-adipose-derived-stromal-cells-to-titanium-dioxide-nanoparticles
#6
Yan Xu, M Hadjiargyrou, Miriam Rafailovich, Tatsiana Mironava
BACKGROUND: Increasing production of nanomaterials requires fast and proper assessment of its potential toxicity. Therefore, there is a need to develop new assays that can be performed in vitro, be cost effective, and allow faster screening of engineered nanomaterials (ENMs). RESULTS: Herein, we report that titanium dioxide (TiO2) nanoparticles (NPs) can induce damage to adipose derived stromal cells (ADSCs) at concentrations which are rated as safe by standard assays such as measuring proliferation, reactive oxygen species (ROS), and lactate dehydrogenase (LDH) levels...
July 11, 2017: Journal of Nanobiotechnology
https://www.readbyqxmd.com/read/28693496/interaction-of-%C3%AE-fe2o3-nanoparticles-with-citrus-maxima-leaves-and-the-corresponding-physiological-effects-via-foliar-application
#7
Jing Hu, Huiyuan Guo, Junli Li, Yunqiang Wang, Lian Xiao, Baoshan Xing
BACKGROUND: Nutrient-containing nanomaterials have been developed as fertilizers to foster plant growth and agricultural yield through root applications. However, if applied through leaves, how these nanomaterials, e.g. γ-Fe2O3 nanoparticles (NPs), influence the plant growth and health are largely unknown. This study is aimed to assess the effects of foliar-applied γ-Fe2O3 NPs and their ionic counterparts on plant physiology of Citrus maxima and the associated mechanisms. RESULTS: No significant changes of chlorophyll content and root activity were observed upon the exposure of 20-100 mg/L γ-Fe2O3 NPs and Fe(3+)...
July 11, 2017: Journal of Nanobiotechnology
https://www.readbyqxmd.com/read/28676089/effects-of-silica-nanoparticle-exposure-on-mitochondrial-function-during-neuronal-differentiation
#8
Angélique D Ducray, Andrea Felser, Jana Zielinski, Aniela Bittner, Julia V Bürgi, Jean-Marc Nuoffer, Martin Frenz, Meike Mevissen
BACKGROUND: Nanomedicine offers a promising tool for therapies of brain diseases, but potential effects on neuronal health and neuronal differentiation need to be investigated to assess potential risks. The aim of this study was to investigate effects of silica-indocyanine green/poly (ε-caprolactone) nanoparticles (PCL-NPs) engineered for laser tissue soldering in the brain before and during differentiation of SH-SY5Y cells. Considering adaptations in mitochondrial homeostasis during neuronal differentiation, metabolic effects of PCL-NP exposure before and during neuronal differentiation were studied...
July 4, 2017: Journal of Nanobiotechnology
https://www.readbyqxmd.com/read/28651541/the-agglomeration-state-of-nanoparticles-can-influence-the-mechanism-of-their-cellular-internalisation
#9
Blanka Halamoda-Kenzaoui, Mara Ceridono, Patricia Urbán, Alessia Bogni, Jessica Ponti, Sabrina Gioria, Agnieszka Kinsner-Ovaskainen
BACKGROUND: Significant progress of nanotechnology, including in particular biomedical and pharmaceutical applications, has resulted in a high number of studies describing the biological effects of nanomaterials. Moreover, a determination of so-called "critical quality attributes", that is specific physicochemical properties of nanomaterials triggering the observed biological response, has been recognised as crucial for the evaluation and design of novel safe and efficacious therapeutics...
June 26, 2017: Journal of Nanobiotechnology
https://www.readbyqxmd.com/read/28645282/swiss-national-research-programme-opportunities-and-risks-of-nanomaterials-nrp-64-key-findings
#10
EDITORIAL
Ueli Aebi, Peter Gehr
No abstract text is available yet for this article.
June 24, 2017: Journal of Nanobiotechnology
https://www.readbyqxmd.com/read/28637475/uptake-of-label-free-graphene-oxide-by-caco-2-cells-is-dependent-on-the-cell-differentiation-status
#11
Melanie Kucki, Liliane Diener, Nils Bohmer, Cordula Hirsch, Harald F Krug, Vincenzo Palermo, Peter Wick
BACKGROUND: Understanding the interaction of graphene-related materials (GRM) with human cells is a key to the assessment of their potential risks for human health. There is a knowledge gap regarding the potential uptake of GRM by human intestinal cells after unintended ingestion. Therefore the aim of our study was to investigate the interaction of label-free graphene oxide (GO) with the intestinal cell line Caco-2 in vitro and to shed light on the influence of the cell phenotype given by the differentiation status on cellular uptake behaviour...
June 21, 2017: Journal of Nanobiotechnology
https://www.readbyqxmd.com/read/28619032/the-role-of-intracellular-trafficking-of-cdse-zns-qds-on-their-consequent-toxicity-profile
#12
Bella B Manshian, Thomas F Martens, Karsten Kantner, Kevin Braeckmans, Stefaan C De Smedt, Jo Demeester, Gareth J S Jenkins, Wolfgang J Parak, Beatriz Pelaz, Shareen H Doak, Uwe Himmelreich, Stefaan J Soenen
BACKGROUND: Nanoparticle interactions with cellular membranes and the kinetics of their transport and localization are important determinants of their functionality and their biological consequences. Understanding these phenomena is fundamental for the translation of such NPs from in vitro to in vivo systems for bioimaging and medical applications. Two CdSe/ZnS quantum dots (QD) with differing surface functionality (NH2 or COOH moieties) were used here for investigating the intracellular uptake and transport kinetics of these QDs...
June 15, 2017: Journal of Nanobiotechnology
https://www.readbyqxmd.com/read/28606090/comparative-efficacy-analysis-of-anti-microbial-peptides-ll-37-and-indolicidin-upon-conjugation-with-cnt-in-human-monocytes
#13
Biswaranjan Pradhan, Dipanjan Guha, Krushna Chandra Murmu, Abhinav Sur, Pratikshya Ray, Debashmita Das, Palok Aich
BACKGROUND: Antimicrobial peptides (AMPs) have the potential to serve as an alternative to antibiotic. AMPs usually exert bactericidal activity via direct killing of microbial pathogens. Reports have proposed that by harnessing innate immune activation, AMPs can regulate pathogen invasion and may control infection. It has been reported that AMPs could be utilized to activate the innate mucosal immune response in order to eliminate pathogenic infections. This way of controlling pathogen infection, by activating host immunity, confers the potential to the select AMPs to alleviate the problem of antibiotic resistance...
June 12, 2017: Journal of Nanobiotechnology
https://www.readbyqxmd.com/read/28592284/biogenic-selenium-nanoparticles-induce-ros-mediated-necroptosis-in-pc-3-cancer-cells-through-tnf-activation
#14
Praveen Sonkusre, Swaranjit Singh Cameotra
BACKGROUND: Selenium is well documented to inhibit cancer at higher doses; however, the mechanism behind this inhibition varies widely depending on the cell type and selenium species. Previously, we have demonstrated that Bacillus licheniformis JS2 derived biogenic selenium nanoparticles (SeNPs) induce non-apoptotic cell death in prostate adenocarcinoma cell line, PC-3, at a minimal concentration of 2 µg Se/ml, without causing toxicity to the primary cells. However, the mechanism behind its anticancer activity was elusive...
June 7, 2017: Journal of Nanobiotechnology
https://www.readbyqxmd.com/read/28578696/nasal-delivery-of-nanoliposome-encapsulated-ferric-ammonium-citrate-can-increase-the-iron-content-of-rat-brain
#15
Xueling Guo, Hong Zheng, Yuetong Guo, Yan Wang, Gregory J Anderson, Yunzhe Ci, Peng Yu, Lina Geng, Yan-Zhong Chang
BACKGROUND: Iron deficiency in children can have significant neurological consequences, and iron supplementation is an effective treatment of choice. However, traditional routes of iron supplementation do not allow efficient iron delivery to the brain due to the presence of the blood-brain barrier. So an easily delivered iron formulation with high absorption efficiency potentially could find widespread application in iron deficient infants. RESULTS: In this study, we have developed and characterized a nanovesicular formulation of ferric ammonium citrate (ferric ammonium citrate nanoliposomes, FAC-LIP) and have shown that it can increase brain iron levels in rats following nasal administration...
June 2, 2017: Journal of Nanobiotechnology
https://www.readbyqxmd.com/read/28521752/synthesis-characterization-and-biological-verification-of-anti-her2-indocyanine-green-doxorubicin-loaded-polyethyleneimine-coated-perfluorocarbon-double-nanoemulsions-for-targeted-photochemotherapy-of-breast-cancer-cells
#16
Yu-Hsiang Lee, Yun-Ting Ma
BACKGROUND: Breast cancer is the most frequently diagnosed cancer and the leading cause of cancer death among females worldwide. Among various types of breast cancer, the human epidermal growth factor receptor 2 (HER2)-overexpressing breast cancer is known to be more aggressive and often resistant to medicinal treatment, leading to an insufficient prognosis and poor susceptibility to chemotherapy and/or hormonal therapy in the current clinic. These circumstances implicate that developing an improved therapeutic strategy rather than persistently changing the anticancer drugs for trying is truly needed to successfully cure this type of breast cancer...
May 18, 2017: Journal of Nanobiotechnology
https://www.readbyqxmd.com/read/28514955/label-free-biosensing-of-salmonella-enterica-serovars-at-single-cell-level
#17
Bin Wang, Bosoon Park, Bingqian Xu, Yongkuk Kwon
BACKGROUND: The emerging nanotechnologies have greatly facilitated the development of label-free biosensors. The atomic force microscopy (AFM) has been used to study the molecular mechanism of the reactions for protein and aptamers. The surface plasmon resonance (SPR) have been used in fast detections of various pathogens such as bacteria. This study used both AFM and SPR to investigate the complex reactions between aptamers and outer membrane proteins (OMPs) on the surface of S. typhimurium...
May 17, 2017: Journal of Nanobiotechnology
https://www.readbyqxmd.com/read/28511687/polymeric-micelles-with-dual-thermal-and-reactive-oxygen-species-ros-responsiveness-for-inflammatory-cancer-cell-delivery
#18
Meiqiong Tang, Ping Hu, Qiang Zheng, Nicola Tirelli, Xiaohong Yang, Zhanlong Wang, Yanfang Wang, Qing Tang, Yun He
BACKGROUND: The object of this study was to develop a thermally and reactive oxygen species-responsive nanocarrier system for cancer therapy. RESULTS: PPS-PNIPAm block copolymer was designed and synthesised using a combination of living anionic ring-opening polymerization and atom transfer radical polymerization. The synthesized polymer formed micellar aggregates in water and demonstrated dual responsiveness towards temperature and oxidants. Using doxorubicin (DOX) as a model drug, encapsulation and in vitro release of the drug molecules in PPS-PNIPAm nanocarriers confirmed the responsive release properties of such system...
May 16, 2017: Journal of Nanobiotechnology
https://www.readbyqxmd.com/read/28482882/targeted-sirna-delivery-reduces-nitric-oxide-mediated-cell-death-after-spinal-cord-injury
#19
Wen Gao, Jianming Li
BACKGROUND: Traumatic spinal cord injury (SCI) includes the primary insult as well as a sequela of biochemical and cellular cascades that amplifies the initial injury. This degenerative process, known as secondary injury, is often mediated by both reactive oxygen and nitrogen species released from damaged cells. Previous data suggests that dysregulated production of nitric oxide via inducible nitric oxide synthase (iNOS) is detrimental to spinal cord recovery. M1 macrophages have been implicated to overexpress iNOS post-SCI...
May 8, 2017: Journal of Nanobiotechnology
https://www.readbyqxmd.com/read/28477617/tracking-single-baculovirus-retrograde-transportation-in-host-cell-via-quantum-dot-labeling-of-virus-internal-component
#20
Li Wen, Zhen-Hua Zheng, An-An Liu, Cheng Lv, Li-Juan Zhang, Jian Ao, Zhi-Ling Zhang, Han-Zhong Wang, Yi Lin, Dai-Wen Pang
BACKGROUND: Quantum dot (QD)-based single virus tracking has become a powerful tool for dissecting virus infection mechanism. However, only virus behaviors at the early stage of retrograde trafficking have been dynamically tracked so far. Monitoring of comprehensive virus retrograde transportation remains a challenge. RESULTS: Based on the superior fluorescence properties of QDs and their labeling of virus internal component, the dynamic interactions between baculoviruses and all key transportation-related cellular structures, including vesicles, acidic endosomes, actins, nuclear pores and nuclei, were visualized at the single-virus level...
May 6, 2017: Journal of Nanobiotechnology
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