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Journal of Nanobiotechnology

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https://www.readbyqxmd.com/read/27919267/targeted-drug-delivery-of-near-ir-fluorescent-doxorubicin-conjugated-poly-ethylene-glycol-bisphosphonate-nanoparticles-for-diagnosis-and-therapy-of-primary-and-metastatic-bone-cancer-in-a-mouse-model
#1
S Rudnick-Glick, E Corem-Salkmon, I Grinberg, S Margel
BACKGROUND: Most primary and metastatic bone tumors demonstrate increased osteoclast activity and bone resorption. Current treatment is based on a combination of surgery, radiotherapy and chemotherapy. Severe side effects are associated with chemotherapy due to use of high dosage and nonspecific uptake. Bisphosphonates have a strong affinity to Ca(2+) ions and are widely used in the treatment of bone disorders. RESULTS: We have engineered a unique biodegradable bisphosphonate nanoparticle (NPs) bearing two functional surface groups: (1) primary amine groups for covalent attachment of a dye/drug (e...
December 5, 2016: Journal of Nanobiotechnology
https://www.readbyqxmd.com/read/27905946/chemically-and-thermally-stable-silica-nanowires-with-a-%C3%AE-sheet-peptide-core-for-bionanotechnology
#2
Zahraa S Al-Garawi, George E Kostakis, Louise C Serpell
BACKGROUND: A series of amyloidogenic peptides based on the sequence KFFEAAAKKFFE template the silica precursor, tetraethyl orthosilicate to form silica-nanowires containing a cross-β peptide core. RESULTS: Investigation of the stability of these fibres reveals that the silica layers protect the silica-nanowires allowing them to maintain their shape and physical and chemical properties after incubation with organic solvents such as 2-propanol, ethanol, and acetonitrile, as well as in a strong acidic solution at pH 1...
December 1, 2016: Journal of Nanobiotechnology
https://www.readbyqxmd.com/read/27903280/a-critical-review-of-the-current-knowledge-regarding-the-biological-impact-of-nanocellulose
#3
REVIEW
C Endes, S Camarero-Espinosa, S Mueller, E J Foster, A Petri-Fink, B Rothen-Rutishauser, C Weder, M J D Clift
Several forms of nanocellulose, notably cellulose nanocrystals and nanofibrillated cellulose, exhibit attractive property matrices and are potentially useful for a large number of industrial applications. These include the paper and cardboard industry, use as reinforcing filler in polymer composites, basis for low-density foams, additive in adhesives and paints, as well as a wide variety of food, hygiene, cosmetic, and medical products. Although the commercial exploitation of nanocellulose has already commenced, little is known as to the potential biological impact of nanocellulose, particularly in its raw form...
December 1, 2016: Journal of Nanobiotechnology
https://www.readbyqxmd.com/read/27894312/release-of-copper-amended-particles-from-micronized-copper-pressure-treated-wood-during-mechanical-abrasion
#4
Chiara Civardi, Lukas Schlagenhauf, Jean-Pierre Kaiser, Cordula Hirsch, Claudio Mucchino, Adrian Wichser, Peter Wick, Francis W M R Schwarze
BACKGROUND: We investigated the particles released due to abrasion of wood surfaces pressure-treated with micronized copper azole (MCA) wood preservative and we gathered preliminary data on its in vitro cytotoxicity for lung cells. The data were compared with particles released after abrasion of untreated, water (0% MCA)-pressure-treated, chromated copper (CC)-pressure-treated wood, and varnished wood. Size, morphology, and composition of the released particles were analyzed. RESULTS: Our results indicate that the abrasion of MCA-pressure-treated wood does not cause an additional release of nanoparticles from the unreacted copper (Cu) carbonate nanoparticles from of the MCA formulation...
November 28, 2016: Journal of Nanobiotechnology
https://www.readbyqxmd.com/read/27887623/generation-of-protective-immunity-against-orientia-tsutsugamushi-infection-by-immunization-with-a-zinc-oxide-nanoparticle-combined-with-scaa-antigen
#5
Na-Young Ha, Hyun Mu Shin, Prashant Sharma, Hyun Ah Cho, Chan-Ki Min, Hong-Il Kim, Nguyen Thi Hai Yen, Jae-Seung Kang, Ik-Sang Kim, Myung-Sik Choi, Young Keun Kim, Nam-Hyuk Cho
BACKGROUND: Zinc oxide nanoparticle (ZNP) has been applied in various biomedical fields. Here, we investigated the usage of ZNP as an antigen carrier for vaccine development by combining a high affinity peptide to ZNP. RESULTS: A novel zinc oxide-binding peptide (ZBP), FPYPGGDA, with high affinity to ZNP (K a  = 2.26 × 10(6) M(-1)) was isolated from a random peptide library and fused with a bacterial antigen, ScaA of Orientia tsutsugamushi, the causative agent of scrub typhus...
November 26, 2016: Journal of Nanobiotechnology
https://www.readbyqxmd.com/read/27884158/rapid-visualization-of-latent-fingermarks-using-gold-seed-mediated-enhancement
#6
Chia-Hao Su, Chun-Chieh Yu, Fong-Yu Cheng
BACKGROUND: Fingermarks are one of the most important and useful forms of physical evidence in forensic investigations. However, latent fingermarks are not directly visible, but can be visualized due to the presence of other residues (such as inorganic salts, proteins, polypeptides, enzymes and human metabolites) which can be detected or recognized through various strategies. Convenient and rapid techniques are still needed to provide obvious contrast between the background and the fingermark ridges and to then visualize latent fingermark with a high degree of selectivity and sensitivity...
November 25, 2016: Journal of Nanobiotechnology
https://www.readbyqxmd.com/read/27809857/high-efficiency-penetration-of-antibody-immobilized-nanoneedle-thorough-plasma-membrane-for-in-situ-detection-of-cytoskeletal-proteins-in-living-cells
#7
R Kawamura, K Shimizu, Y Matsumoto, A Yamagishi, Y R Silberberg, M Iijima, S Kuroda, K Fukazawa, K Ishihara, C Nakamura
BACKGROUND: The field of structural dynamics of cytoskeletons in living cells is gathering wide interest, since better understanding of cytoskeleton intracellular organization will provide us with not only insights into basic cell biology but may also enable development of new strategies in regenerative medicine and cancer therapy, fields in which cytoskeleton-dependent dynamics play a pivotal role. The nanoneedle technology is a powerful tool allowing for intracellular investigations, as it can be directly inserted into live cells by penetrating through the plasma membrane causing minimal damage to cells, under the precise manipulation using atomic force microscope...
November 3, 2016: Journal of Nanobiotechnology
https://www.readbyqxmd.com/read/27776555/pure-and-multi-metal-oxide-nanoparticles-synthesis-antibacterial-and-cytotoxic-properties
#8
Slavica Stankic, Sneha Suman, Francia Haque, Jasmina Vidic
Th antibacterial activity of metal oxide nanoparticles has received marked global attention as they can be specifically synthesized to exhibit significant toxicity to bacteria. The importance of their application as antibacterial agents is evident keeping in mind the limited range and effectiveness of antibiotics, on one hand, and the plethora of metal oxides, on the other, along with the propensity of nanoparticles to induce resistance being much lower than that of antibiotics. Effective inhibition against a wide range of bacteria is well known for several nano oxides consisting of one metal (Fe3O4, TiO2, CuO, ZnO), whereas, research in the field of multi-metal oxides still demands extensive exploration...
October 24, 2016: Journal of Nanobiotechnology
https://www.readbyqxmd.com/read/27769275/calcium-silicate-mesoporous-nanoparticles-loaded-with-chlorhexidine-for-both-anti-enterococcus-faecalis-and-mineralization-properties
#9
Wei Fan, Yanyun Li, Qing Sun, Tengjiao Ma, Bing Fan
BACKGROUND: In infected periapical tissues, Enterococcus faecalis is one of the most common dominant bacteria. Chlorhexidine has been proved to show strong antibacterial ability against E. faecalis but is ineffective in promoting mineralization for tissues around root apex. Mesoporous calcium-silicate nanoparticles are newly synthesized biomaterials with excellent ability to promote mineralization and carry-release bioactive molecules in a controlled manner. In this study, mesoporous calcium-silicate nanoparticles were functionalized with chlorhexidine and their releasing profile, antibacterial ability, effect on cell proliferation and in vitro mineralization property were evaluated...
October 21, 2016: Journal of Nanobiotechnology
https://www.readbyqxmd.com/read/27716314/lipid-nanoemulsions-and-liposomes-improve-photodynamic-treatment-efficacy-and-tolerance-in-cal-33-tumor-bearing-nude-mice
#10
Doris Hinger, Susanna Gräfe, Fabrice Navarro, Bernhard Spingler, Devaraj Pandiarajan, Heinrich Walt, Anne-Claude Couffin, Caroline Maake
BACKGROUND: Photodynamic therapy (PDT) as promising alternative to conventional cancer treatments works by irradiation of a photosensitizer (PS) with light, which creates reactive oxygen species and singlet oxygen ((1)O2), that damage the tumor. However, a routine use is hindered by the PS's poor water solubility and extended cutaneous photosensitivity of patients after treatment. In our study we sought to overcome these limitations by encapsulation of the PS m-tetrahydroxyphenylchlorin (mTHPC) into a biocompatible nanoemulsion (Lipidots)...
October 3, 2016: Journal of Nanobiotechnology
https://www.readbyqxmd.com/read/27669686/penetration-of-cdse-zns-quantum-dots-into-differentiated-vs-undifferentiated-caco-2-cells
#11
Henrike Peuschel, Thomas Ruckelshausen, Silke Kiefer, Yuliya Silina, Annette Kraegeloh
BACKGROUND: Quantum dots (QDs) have great potential as fluorescent labels but cytotoxicity relating to extra- and intracellular degradation in biological systems has to be addressed prior to biomedical applications. In this study, human intestinal cells (Caco-2) grown on transwell membranes were used to study penetration depth, intracellular localization, translocation and cytotoxicity of CdSe/ZnS QDs with amino and carboxyl surface modifications. The focus of this study was to compare the penetration depth of QDs in differentiated vs undifferentiated cells using confocal microscopy and image processing...
September 26, 2016: Journal of Nanobiotechnology
https://www.readbyqxmd.com/read/27015946/observation-of-yttrium-oxide-nanoparticles-in-cabbage-brassica-oleracea-through-dual-energy-k-edge-subtraction-imaging
#12
Yunyun Chen, Carlos Sanchez, Yuan Yue, Mauricio de Almeida, Jorge M González, Dilworth Y Parkinson, Hong Liang
BACKGROUND: The potential transfer of engineered nanoparticles (ENPs) from plants into the food chain has raised widespread concerns. In order to investigate the effects of ENPs on plants, young cabbage plants (Brassica oleracea) were exposed to a hydroponic system containing yttrium oxide (yttria) ENPs. The objective of this study was to reveal the impacts of NPs on plants by using K-edge subtraction imaging technique. RESULTS: Using synchrotron dual-energy X-ray micro-tomography with K-edge subtraction technique, we studied the uptake, accumulation, distribution and concentration mapping of yttria ENPs in cabbage plants...
March 25, 2016: Journal of Nanobiotechnology
https://www.readbyqxmd.com/read/26775253/engineered-atherosclerosis-specific-zinc-ferrite-nanocomplex-based-mri-contrast-agents
#13
Rajneesh Chaudhary, Kislay Roy, Rupinder Kaur Kanwar, Ken Walder, Jagat Rakesh Kanwar
BACKGROUND: Cardiovascular diseases are the most prevalent cause of morbidity and mortality affecting millions of people globally. The most effective way to counter cardiovascular complications is early diagnosis and the safest non-invasive diagnostic approach is magnetic resonance imaging (MRI). In this study, superparamagnetic ferrite nanoparticles doped with zinc, exhibiting highly enhanced saturation magnetization and T2 and computed tomography (CT) contrast were synthesized. These nanoparticles have been strategically engineered using bovine lactoferrin (Lf), polyethylene glycol (PEG), and heat shock protein (Hsp)-70 antibody specifically targeting atherosclerosis with potential therapeutic value...
January 16, 2016: Journal of Nanobiotechnology
https://www.readbyqxmd.com/read/26772816/efficient-biodegradation-of-chlorophenols-in-aqueous-phase-by-magnetically-immobilized-aniline-degrading-rhodococcus-rhodochrous-strain
#14
Jianfeng Hou, Feixia Liu, Nan Wu, Jiansong Ju, Bo Yu
BACKGROUND: Chlorophenols are environmental contaminants, which are highly toxic to living beings due to their carcinogenic, mutagenic and cytotoxic properties. Bacterial degradation has been considered a cost-effective and eco-friendly method of removing chlorophenols, compared to the traditional physical-chemical processes. RESULTS: In this study, we first developed an efficient process for the biodegradation of chlorophenols by magnetically immobilized Rhodococcus rhodochrous cells...
January 16, 2016: Journal of Nanobiotechnology
https://www.readbyqxmd.com/read/26768888/semi-automated-quantification-of-living-cells-with-internalized-nanostructures
#15
Michael Bogdan Margineanu, Khachatur Julfakyan, Christoph Sommer, Jose Efrain Perez, Maria Fernanda Contreras, Niveen Khashab, Jürgen Kosel, Timothy Ravasi
BACKGROUND: Nanostructures fabricated by different methods have become increasingly important for various applications in biology and medicine, such as agents for medical imaging or cancer therapy. In order to understand their interaction with living cells and their internalization kinetics, several attempts have been made in tagging them. Although methods have been developed to measure the number of nanostructures internalized by the cells, there are only few approaches aimed to measure the number of cells that internalize the nanostructures, and they are usually limited to fixed-cell studies...
January 15, 2016: Journal of Nanobiotechnology
https://www.readbyqxmd.com/read/26753543/electrophoretic-deposition-of-ligand-free-platinum-nanoparticles-on-neural-electrodes-affects-their-impedance-in-vitro-and-in-vivo-with-no-negative-effect-on-reactive-gliosis
#16
Svilen D Angelov, Sven Koenen, Jurij Jakobi, Hans E Heissler, Mesbah Alam, Kerstin Schwabe, Stephan Barcikowski, Joachim K Krauss
BACKGROUND: Electrodes for neural stimulation and recording are used for the treatment of neurological disorders. Their features critically depend on impedance and interaction with brain tissue. The effect of surface modification on electrode impedance was examined in vitro and in vivo after intracranial implantation in rats. Electrodes coated by electrophoretic deposition with platinum nanoparticles (NP; <10 and 50 nm) as well as uncoated references were implanted into the rat's subthalamic nucleus...
January 12, 2016: Journal of Nanobiotechnology
https://www.readbyqxmd.com/read/26745990/optical-and-electron-microscopy-study-of-laser-based-intracellular-molecule-delivery-using-peptide-conjugated-photodispersible-gold-nanoparticle-agglomerates
#17
Judith Krawinkel, Undine Richter, Maria Leilani Torres-Mapa, Martin Westermann, Lisa Gamrad, Christoph Rehbock, Stephan Barcikowski, Alexander Heisterkamp
BACKGROUND: Cell-penetrating peptides (CPPs) can act as carriers for therapeutic molecules such as drugs and genetic constructs for medical applications. The triggered release of the molecule into the cytoplasm can be crucial to its effective delivery. Hence, we implemented and characterized laser interaction with defined gold nanoparticle agglomerates conjugated to CPPs which enables efficient endosomal rupture and intracellular release of molecules transported. RESULTS: Gold nanoparticles generated by pulsed laser ablation in liquid were conjugated with CPPs forming agglomerates and the intracellular release of molecules was triggered via pulsed laser irradiation (γ = 532 nm, τ pulse = 1 ns)...
January 8, 2016: Journal of Nanobiotechnology
https://www.readbyqxmd.com/read/26743777/cellular-uptake-and-intracellular-degradation-of-poly-alkyl-cyanoacrylate-nanoparticles
#18
Einar Sulheim, Habib Baghirov, Eva von Haartman, Andreas Bøe, Andreas K O Åslund, Yrr Mørch, Catharina de Lange Davies
BACKGROUND: Poly(alkyl cyanoacrylate) (PACA) nanoparticles have shown promise as drug carriers both to solid tumors and across the blood-brain barrier. Efficient drug delivery requires both high cellular uptake of the nanoparticles and release of the drug from the nanoparticles. Release of hydrophobic drugs from PACA nanoparticles is primarily governed by nanoparticle degradation, and this process has been poorly studied at the cellular level. Here we use the hydrophobic model drug Nile Red 668 (NR668) to investigate intracellular degradation of PACA nanoparticles by measuring changes in NR668 fluorescence emission and lifetime, as the spectral properties of NR668 depend on the hydrophobicity of the dye environment...
January 8, 2016: Journal of Nanobiotechnology
https://www.readbyqxmd.com/read/27613519/the-impact-of-species-and-cell-type-on-the-nanosafety-profile-of-iron-oxide-nanoparticles-in-neural-cells
#19
Freya Joris, Daniel Valdepérez, Beatriz Pelaz, Stefaan J Soenen, Bella B Manshian, Wolfgang J Parak, Stefaan C De Smedt, Koen Raemdonck
BACKGROUND: While nanotechnology is advancing rapidly, nanosafety tends to lag behind since general mechanistic insights into cell-nanoparticle (NP) interactions remain rare. To tackle this issue, standardization of nanosafety assessment is imperative. In this regard, we believe that the cell type selection should not be overlooked since the applicability of cell lines could be questioned given their altered phenotype. Hence, we evaluated the impact of the cell type on in vitro nanosafety evaluations in a human and murine neuroblastoma cell line, neural progenitor cell line and in neural stem cells...
2016: Journal of Nanobiotechnology
https://www.readbyqxmd.com/read/27604187/photoinduced-effects-of-m-tetrahydroxyphenylchlorin-loaded-lipid-nanoemulsions-on-multicellular-tumor-spheroids
#20
Doris Hinger, Fabrice Navarro, Andres Käch, Jean-Sébastien Thomann, Frédérique Mittler, Anne-Claude Couffin, Caroline Maake
BACKGROUND: Photosensitizers are used in photodynamic therapy (PDT) to destruct tumor cells, however, their limited solubility and specificity hampers routine use, which may be overcome by encapsulation. Several promising novel nanoparticulate drug carriers including liposomes, polymeric nanoparticles, metallic nanoparticles and lipid nanocomposites have been developed. However, many of them contain components that would not meet safety standards of regulatory bodies and due to difficulties of the manufacturing processes, reproducibility and scale up procedures these drugs may eventually not reach the clinics...
2016: Journal of Nanobiotechnology
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