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Journal of Nanobiotechnology

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https://www.readbyqxmd.com/read/28877692/the-use-of-a-p-falciparum-specific-coiled-coil-domain-to-construct-a-self-assembling-protein-nanoparticle-vaccine-to-prevent-malaria
#1
Christopher P Karch, Tais A P F Doll, Sara M Paulillo, Issa Nebie, David E Lanar, Giampietro Corradin, Peter Burkhard
BACKGROUND: The parasitic disease malaria remains a major global public health concern and no truly effective vaccine exists. One approach to the development of a malaria vaccine is to target the asexual blood stage that results in clinical symptoms. Most attempts have failed. New antigens such as P27A and P27 have emerged as potential new vaccine candidates. Multiple studies have demonstrated that antigens are more immunogenic and are better correlated with protection when presented on particulate delivery systems...
September 6, 2017: Journal of Nanobiotechnology
https://www.readbyqxmd.com/read/28877691/alternative-moth-eye-nanostructures-antireflective-properties-and-composition-of-dimpled-corneal-nanocoatings-in-silk-moth-ancestors
#2
Mikhail Kryuchkov, Jannis Lehmann, Jakob Schaab, Vsevolod Cherepanov, Artem Blagodatski, Manfred Fiebig, Vladimir L Katanaev
Moth-eye nanostructures are a well-known example of biological antireflective surfaces formed by pseudoregular arrays of nipples and are often used as a template for biomimetic materials. Here, we provide morphological characterization of corneal nanostructures of moths from the Bombycidae family, including strains of domesticated Bombyx mori silk-moth, its wild ancestor Bombyx mandarina, and a more distantly related Apatelodes torrefacta. We find high diversification of the nanostructures and strong antireflective properties they provide...
September 6, 2017: Journal of Nanobiotechnology
https://www.readbyqxmd.com/read/28870210/hemostatic-bioactivity-of-novel-pollen-typhae-carbonisata-derived-carbon-quantum-dots
#3
Xin Yan, Yan Zhao, Juan Luo, Wei Xiong, Xiaoman Liu, Jinjun Cheng, Yongzhi Wang, Meiling Zhang, Huihua Qu
BACKGROUND: Pollen Typhae Carbonisata (PTC) is a type of calcined herb drug that has been used as a hemostatic medicine to promote hemostasis for thousands of years. In this study, we discovered and separated novel water-soluble carbon quantum dots (CQDs, named PTC-CQDs) from aqueous extracts of PTC. These PTC-CDs were characterized using transmission electron microscopy (TEM) and high-resolution TEM, as well as Fourier transform infrared, ultraviolet-visible, and fluorescence spectroscopy...
September 5, 2017: Journal of Nanobiotechnology
https://www.readbyqxmd.com/read/28830490/characteristics-and-properties-of-nano-licoo2-synthesized-by-pre-organized-single-source-precursors-li-ion-diffusivity-electrochemistry-and-biological-assessment
#4
Jean-Pierre Brog, Aurélien Crochet, Joël Seydoux, Martin J D Clift, Benoît Baichette, Sivarajakumar Maharajan, Hana Barosova, Pierre Brodard, Mariana Spodaryk, Andreas Züttel, Barbara Rothen-Rutishauser, Nam Hee Kwon, Katharina M Fromm
BACKGROUND: LiCoO2 is one of the most used cathode materials in Li-ion batteries. Its conventional synthesis requires high temperature (>800 °C) and long heating time (>24 h) to obtain the micronscale rhombohedral layered high-temperature phase of LiCoO2 (HT-LCO). Nanoscale HT-LCO is of interest to improve the battery performance as the lithium (Li(+)) ion pathway is expected to be shorter in nanoparticles as compared to micron sized ones. Since batteries typically get recycled, the exposure to nanoparticles during this process needs to be evaluated...
August 22, 2017: Journal of Nanobiotechnology
https://www.readbyqxmd.com/read/28830447/nanostructured-biosensor-using-bioluminescence-quenching-technique-for-glucose-detection
#5
Longyan Chen, Longyi Chen, Michelle Dotzert, C W James Melling, Jin Zhang
BACKGROUND: Most methods for monitoring glucose level require an external energy source which may limit their application, particularly in vivo test. Bioluminescence technique offers an alternative way to provide emission light without external energy source by using bioluminescent proteins found from firefly or marine vertebrates and invertebrates. For quick and non-invasive detection of glucose, we herein developed a nanostructured biosensor by applying the bioluminescence technique...
August 22, 2017: Journal of Nanobiotechnology
https://www.readbyqxmd.com/read/28764786/evaluation-of-the-antibacterial-power-and-biocompatibility-of-zinc-oxide-nanorods-decorated-graphene-nanoplatelets-new-perspectives-for-antibiodeteriorative-approaches
#6
Elena Zanni, Erika Bruni, Chandrakanth Reddy Chandraiahgari, Giovanni De Bellis, Maria Grazia Santangelo, Maurizio Leone, Agnese Bregnocchi, Patrizia Mancini, Maria Sabrina Sarto, Daniela Uccelletti
BACKGROUND: Nanotechnologies are currently revolutionizing the world around us, improving the quality of our lives thanks to a multitude of applications in several areas including the environmental preservation, with the biodeterioration phenomenon representing one of the major concerns. RESULTS: In this study, an innovative nanomaterial consisting of graphene nanoplatelets decorated by zinc oxide nanorods (ZNGs) was tested for the ability to inhibit two different pathogens belonging to bacterial genera frequently associated with nosocomial infections as well as biodeterioration phenomenon: the Gram-positive Staphylococcus aureus and the Gram-negative Pseudomonas aeruginosa...
August 1, 2017: Journal of Nanobiotechnology
https://www.readbyqxmd.com/read/28743275/block-copolymer-conjugated-au-coated-fe3o4-nanoparticles-as-vectors-for-enhancing-colloidal-stability-and-cellular-uptake
#7
Junbo Li, Sheng Zou, Jiayu Gao, Ju Liang, Huiyun Zhou, Lijuan Liang, Wenlan Wu
BACKGROUND: Polymer surface-modified inorganic nanoparticles (NPs) provide a multifunctional platform for assisting gene delivery. Rational structure design for enhancing colloidal stability and cellular uptake is an important strategy in the development of safe and highly efficient gene vectors. RESULTS: Heterogeneous Au-coated Fe3O4 (Fe3O4@Au) NPs capped by polyethylene glycol-b-poly1-(3-aminopropyl)-3-(2-methacryloyloxy propylimidazolium bromine) (PEG-b-PAMPImB-Fe3O4@Au) were prepared for DNA loading and magnetofection assays...
July 25, 2017: Journal of Nanobiotechnology
https://www.readbyqxmd.com/read/28732539/enzyme-adsorption-induced-activity-changes-a-quantitative-study-on-tio2-model-agglomerates
#8
Augusto Márquez, Krisztina Kocsis, Gregor Zickler, Gilles R Bourret, Andrea Feinle, Nicola Hüsing, Martin Himly, Albert Duschl, Thomas Berger, Oliver Diwald
BACKGROUND: Activity retention upon enzyme adsorption on inorganic nanostructures depends on different system parameters such as structure and composition of the support, composition of the medium as well as enzyme loading. Qualitative and quantitative characterization work, which aims at an elucidation of the microscopic details governing enzymatic activity, requires well-defined model systems. RESULTS: Vapor phase-grown and thermally processed anatase TiO2 nanoparticle powders were transformed into aqueous particle dispersions and characterized by dynamic light scattering and laser Doppler electrophoresis...
July 21, 2017: Journal of Nanobiotechnology
https://www.readbyqxmd.com/read/28720097/a-versatile-papaya-mosaic-virus-papmv-vaccine-platform-based-on-sortase-mediated-antigen-coupling
#9
Ariane Thérien, Mikaël Bédard, Damien Carignan, Gervais Rioux, Louis Gauthier-Landry, Marie-Ève Laliberté-Gagné, Marilène Bolduc, Pierre Savard, Denis Leclerc
BACKGROUND: Flexuous rod-shaped nanoparticles made of the coat protein (CP) of papaya mosaic virus (PapMV) have been shown to trigger innate immunity through engagement of toll-like receptor 7 (TLR7). PapMV nanoparticles can also serve as a vaccine platform as they can increase the immune response to fused peptide antigens. Although this approach shows great potential, fusion of antigens directly to the CP open reading frame (ORF) is challenging because the fused peptides can alter the structure of the CP and its capacity to self assemble into nanoparticles-a property essential for triggering an efficient immune response to the peptide...
July 18, 2017: Journal of Nanobiotechnology
https://www.readbyqxmd.com/read/28716122/systematic-evaluation-of-oligodeoxynucleotide-binding-and-hybridization-to-modified-multi-walled-carbon-nanotubes
#10
Anika Kaufmann, Silke Hampel, Christiane Rieger, David Kunhardt, Darja Schendel, Susanne Füssel, Bernd Schwenzer, Kati Erdmann
BACKGROUND: In addition to conventional chemotherapeutics, nucleic acid-based therapeutics like antisense oligodeoxynucleotides (AS-ODN) represent a novel approach for the treatment of bladder cancer (BCa). An efficient delivery of AS-ODN to the urothelium and then into cancer cells might be achieved by the local application of multi-walled carbon nanotubes (MWCNT). In the present study, pristine MWCNT and MWCNT functionalized with hydrophilic moieties were synthesized and then investigated regarding their physicochemical characteristics, dispersibility, biocompatibility, cellular uptake and mucoadhesive properties...
July 17, 2017: Journal of Nanobiotechnology
https://www.readbyqxmd.com/read/28705169/antireflective-nanocoatings-for-uv-sensation-the-case-of-predatory-owlfly-insects
#11
LETTER
Mikhail Kryuchkov, Jannis Lehmann, Jakob Schaab, Manfred Fiebig, Vladimir L Katanaev
Moth-eye nanostructures, discovered to coat corneae of certain nocturnal insects, have inspired numerous technological applications to reduce light reflectance from solar cells, light-emitting diodes, and optical detectors. Technological developments require such nanocoatings to possess broadband antireflective properties, transcending the visual light spectrum, in which animals typically operate. Here we describe the corneal nanostructures of the visual organ exclusive in UV sensation of the hunting insect Libelloides macaronius and report their supreme anti-light-reflectance capacity...
July 14, 2017: Journal of Nanobiotechnology
https://www.readbyqxmd.com/read/28693576/cell-based-cytotoxicity-assays-for-engineered-nanomaterials-safety-screening-exposure-of-adipose-derived-stromal-cells-to-titanium-dioxide-nanoparticles
#12
Yan Xu, M Hadjiargyrou, Miriam Rafailovich, Tatsiana Mironava
BACKGROUND: Increasing production of nanomaterials requires fast and proper assessment of its potential toxicity. Therefore, there is a need to develop new assays that can be performed in vitro, be cost effective, and allow faster screening of engineered nanomaterials (ENMs). RESULTS: Herein, we report that titanium dioxide (TiO2) nanoparticles (NPs) can induce damage to adipose derived stromal cells (ADSCs) at concentrations which are rated as safe by standard assays such as measuring proliferation, reactive oxygen species (ROS), and lactate dehydrogenase (LDH) levels...
July 11, 2017: Journal of Nanobiotechnology
https://www.readbyqxmd.com/read/28693496/interaction-of-%C3%AE-fe2o3-nanoparticles-with-citrus-maxima-leaves-and-the-corresponding-physiological-effects-via-foliar-application
#13
Jing Hu, Huiyuan Guo, Junli Li, Yunqiang Wang, Lian Xiao, Baoshan Xing
BACKGROUND: Nutrient-containing nanomaterials have been developed as fertilizers to foster plant growth and agricultural yield through root applications. However, if applied through leaves, how these nanomaterials, e.g. γ-Fe2O3 nanoparticles (NPs), influence the plant growth and health are largely unknown. This study is aimed to assess the effects of foliar-applied γ-Fe2O3 NPs and their ionic counterparts on plant physiology of Citrus maxima and the associated mechanisms. RESULTS: No significant changes of chlorophyll content and root activity were observed upon the exposure of 20-100 mg/L γ-Fe2O3 NPs and Fe(3+)...
July 11, 2017: Journal of Nanobiotechnology
https://www.readbyqxmd.com/read/28676089/effects-of-silica-nanoparticle-exposure-on-mitochondrial-function-during-neuronal-differentiation
#14
Angélique D Ducray, Andrea Felser, Jana Zielinski, Aniela Bittner, Julia V Bürgi, Jean-Marc Nuoffer, Martin Frenz, Meike Mevissen
BACKGROUND: Nanomedicine offers a promising tool for therapies of brain diseases, but potential effects on neuronal health and neuronal differentiation need to be investigated to assess potential risks. The aim of this study was to investigate effects of silica-indocyanine green/poly (ε-caprolactone) nanoparticles (PCL-NPs) engineered for laser tissue soldering in the brain before and during differentiation of SH-SY5Y cells. Considering adaptations in mitochondrial homeostasis during neuronal differentiation, metabolic effects of PCL-NP exposure before and during neuronal differentiation were studied...
July 4, 2017: Journal of Nanobiotechnology
https://www.readbyqxmd.com/read/28651541/the-agglomeration-state-of-nanoparticles-can-influence-the-mechanism-of-their-cellular-internalisation
#15
Blanka Halamoda-Kenzaoui, Mara Ceridono, Patricia Urbán, Alessia Bogni, Jessica Ponti, Sabrina Gioria, Agnieszka Kinsner-Ovaskainen
BACKGROUND: Significant progress of nanotechnology, including in particular biomedical and pharmaceutical applications, has resulted in a high number of studies describing the biological effects of nanomaterials. Moreover, a determination of so-called "critical quality attributes", that is specific physicochemical properties of nanomaterials triggering the observed biological response, has been recognised as crucial for the evaluation and design of novel safe and efficacious therapeutics...
June 26, 2017: Journal of Nanobiotechnology
https://www.readbyqxmd.com/read/28645282/swiss-national-research-programme-opportunities-and-risks-of-nanomaterials-nrp-64-key-findings
#16
EDITORIAL
Ueli Aebi, Peter Gehr
No abstract text is available yet for this article.
June 24, 2017: Journal of Nanobiotechnology
https://www.readbyqxmd.com/read/28637475/uptake-of-label-free-graphene-oxide-by-caco-2-cells-is-dependent-on-the-cell-differentiation-status
#17
Melanie Kucki, Liliane Diener, Nils Bohmer, Cordula Hirsch, Harald F Krug, Vincenzo Palermo, Peter Wick
BACKGROUND: Understanding the interaction of graphene-related materials (GRM) with human cells is a key to the assessment of their potential risks for human health. There is a knowledge gap regarding the potential uptake of GRM by human intestinal cells after unintended ingestion. Therefore the aim of our study was to investigate the interaction of label-free graphene oxide (GO) with the intestinal cell line Caco-2 in vitro and to shed light on the influence of the cell phenotype given by the differentiation status on cellular uptake behaviour...
June 21, 2017: Journal of Nanobiotechnology
https://www.readbyqxmd.com/read/28619032/the-role-of-intracellular-trafficking-of-cdse-zns-qds-on-their-consequent-toxicity-profile
#18
Bella B Manshian, Thomas F Martens, Karsten Kantner, Kevin Braeckmans, Stefaan C De Smedt, Jo Demeester, Gareth J S Jenkins, Wolfgang J Parak, Beatriz Pelaz, Shareen H Doak, Uwe Himmelreich, Stefaan J Soenen
BACKGROUND: Nanoparticle interactions with cellular membranes and the kinetics of their transport and localization are important determinants of their functionality and their biological consequences. Understanding these phenomena is fundamental for the translation of such NPs from in vitro to in vivo systems for bioimaging and medical applications. Two CdSe/ZnS quantum dots (QD) with differing surface functionality (NH2 or COOH moieties) were used here for investigating the intracellular uptake and transport kinetics of these QDs...
June 15, 2017: Journal of Nanobiotechnology
https://www.readbyqxmd.com/read/28606090/comparative-efficacy-analysis-of-anti-microbial-peptides-ll-37-and-indolicidin-upon-conjugation-with-cnt-in-human-monocytes
#19
COMPARATIVE STUDY
Biswaranjan Pradhan, Dipanjan Guha, Krushna Chandra Murmu, Abhinav Sur, Pratikshya Ray, Debashmita Das, Palok Aich
BACKGROUND: Antimicrobial peptides (AMPs) have the potential to serve as an alternative to antibiotic. AMPs usually exert bactericidal activity via direct killing of microbial pathogens. Reports have proposed that by harnessing innate immune activation, AMPs can regulate pathogen invasion and may control infection. It has been reported that AMPs could be utilized to activate the innate mucosal immune response in order to eliminate pathogenic infections. This way of controlling pathogen infection, by activating host immunity, confers the potential to the select AMPs to alleviate the problem of antibiotic resistance...
June 12, 2017: Journal of Nanobiotechnology
https://www.readbyqxmd.com/read/28592284/biogenic-selenium-nanoparticles-induce-ros-mediated-necroptosis-in-pc-3-cancer-cells-through-tnf-activation
#20
Praveen Sonkusre, Swaranjit Singh Cameotra
BACKGROUND: Selenium is well documented to inhibit cancer at higher doses; however, the mechanism behind this inhibition varies widely depending on the cell type and selenium species. Previously, we have demonstrated that Bacillus licheniformis JS2 derived biogenic selenium nanoparticles (SeNPs) induce non-apoptotic cell death in prostate adenocarcinoma cell line, PC-3, at a minimal concentration of 2 µg Se/ml, without causing toxicity to the primary cells. However, the mechanism behind its anticancer activity was elusive...
June 7, 2017: Journal of Nanobiotechnology
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