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Journal of Nanobiotechnology

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https://www.readbyqxmd.com/read/28645282/swiss-national-research-programme-opportunities-and-risks-of-nanomaterials-nrp-64-key-findings
#1
EDITORIAL
Ueli Aebi, Peter Gehr
No abstract text is available yet for this article.
June 24, 2017: Journal of Nanobiotechnology
https://www.readbyqxmd.com/read/28637475/uptake-of-label-free-graphene-oxide-by-caco-2-cells-is-dependent-on-the-cell-differentiation-status
#2
Melanie Kucki, Liliane Diener, Nils Bohmer, Cordula Hirsch, Harald F Krug, Vincenzo Palermo, Peter Wick
BACKGROUND: Understanding the interaction of graphene-related materials (GRM) with human cells is a key to the assessment of their potential risks for human health. There is a knowledge gap regarding the potential uptake of GRM by human intestinal cells after unintended ingestion. Therefore the aim of our study was to investigate the interaction of label-free graphene oxide (GO) with the intestinal cell line Caco-2 in vitro and to shed light on the influence of the cell phenotype given by the differentiation status on cellular uptake behaviour...
June 21, 2017: Journal of Nanobiotechnology
https://www.readbyqxmd.com/read/28619032/the-role-of-intracellular-trafficking-of-cdse-zns-qds-on-their-consequent-toxicity-profile
#3
Bella B Manshian, Thomas F Martens, Karsten Kantner, Kevin Braeckmans, Stefaan C De Smedt, Jo Demeester, Gareth J S Jenkins, Wolfgang J Parak, Beatriz Pelaz, Shareen H Doak, Uwe Himmelreich, Stefaan J Soenen
BACKGROUND: Nanoparticle interactions with cellular membranes and the kinetics of their transport and localization are important determinants of their functionality and their biological consequences. Understanding these phenomena is fundamental for the translation of such NPs from in vitro to in vivo systems for bioimaging and medical applications. Two CdSe/ZnS quantum dots (QD) with differing surface functionality (NH2 or COOH moieties) were used here for investigating the intracellular uptake and transport kinetics of these QDs...
June 15, 2017: Journal of Nanobiotechnology
https://www.readbyqxmd.com/read/28606090/comparative-efficacy-analysis-of-anti-microbial-peptides-ll-37-and-indolicidin-upon-conjugation-with-cnt-in-human-monocytes
#4
Biswaranjan Pradhan, Dipanjan Guha, Krushna Chandra Murmu, Abhinav Sur, Pratikshya Ray, Debashmita Das, Palok Aich
BACKGROUND: Antimicrobial peptides (AMPs) have the potential to serve as an alternative to antibiotic. AMPs usually exert bactericidal activity via direct killing of microbial pathogens. Reports have proposed that by harnessing innate immune activation, AMPs can regulate pathogen invasion and may control infection. It has been reported that AMPs could be utilized to activate the innate mucosal immune response in order to eliminate pathogenic infections. This way of controlling pathogen infection, by activating host immunity, confers the potential to the select AMPs to alleviate the problem of antibiotic resistance...
June 12, 2017: Journal of Nanobiotechnology
https://www.readbyqxmd.com/read/28592284/biogenic-selenium-nanoparticles-induce-ros-mediated-necroptosis-in-pc-3-cancer-cells-through-tnf-activation
#5
Praveen Sonkusre, Swaranjit Singh Cameotra
BACKGROUND: Selenium is well documented to inhibit cancer at higher doses; however, the mechanism behind this inhibition varies widely depending on the cell type and selenium species. Previously, we have demonstrated that Bacillus licheniformis JS2 derived biogenic selenium nanoparticles (SeNPs) induce non-apoptotic cell death in prostate adenocarcinoma cell line, PC-3, at a minimal concentration of 2 µg Se/ml, without causing toxicity to the primary cells. However, the mechanism behind its anticancer activity was elusive...
June 7, 2017: Journal of Nanobiotechnology
https://www.readbyqxmd.com/read/28578696/nasal-delivery-of-nanoliposome-encapsulated-ferric-ammonium-citrate-can-increase-the-iron-content-of-rat-brain
#6
Xueling Guo, Hong Zheng, Yuetong Guo, Yan Wang, Gregory J Anderson, Yunzhe Ci, Peng Yu, Lina Geng, Yan-Zhong Chang
BACKGROUND: Iron deficiency in children can have significant neurological consequences, and iron supplementation is an effective treatment of choice. However, traditional routes of iron supplementation do not allow efficient iron delivery to the brain due to the presence of the blood-brain barrier. So an easily delivered iron formulation with high absorption efficiency potentially could find widespread application in iron deficient infants. RESULTS: In this study, we have developed and characterized a nanovesicular formulation of ferric ammonium citrate (ferric ammonium citrate nanoliposomes, FAC-LIP) and have shown that it can increase brain iron levels in rats following nasal administration...
June 2, 2017: Journal of Nanobiotechnology
https://www.readbyqxmd.com/read/28521752/synthesis-characterization-and-biological-verification-of-anti-her2-indocyanine-green-doxorubicin-loaded-polyethyleneimine-coated-perfluorocarbon-double-nanoemulsions-for-targeted-photochemotherapy-of-breast-cancer-cells
#7
Yu-Hsiang Lee, Yun-Ting Ma
BACKGROUND: Breast cancer is the most frequently diagnosed cancer and the leading cause of cancer death among females worldwide. Among various types of breast cancer, the human epidermal growth factor receptor 2 (HER2)-overexpressing breast cancer is known to be more aggressive and often resistant to medicinal treatment, leading to an insufficient prognosis and poor susceptibility to chemotherapy and/or hormonal therapy in the current clinic. These circumstances implicate that developing an improved therapeutic strategy rather than persistently changing the anticancer drugs for trying is truly needed to successfully cure this type of breast cancer...
May 18, 2017: Journal of Nanobiotechnology
https://www.readbyqxmd.com/read/28514955/label-free-biosensing-of-salmonella-enterica-serovars-at-single-cell-level
#8
Bin Wang, Bosoon Park, Bingqian Xu, Yongkuk Kwon
BACKGROUND: The emerging nanotechnologies have greatly facilitated the development of label-free biosensors. The atomic force microscopy (AFM) has been used to study the molecular mechanism of the reactions for protein and aptamers. The surface plasmon resonance (SPR) have been used in fast detections of various pathogens such as bacteria. This study used both AFM and SPR to investigate the complex reactions between aptamers and outer membrane proteins (OMPs) on the surface of S. typhimurium...
May 17, 2017: Journal of Nanobiotechnology
https://www.readbyqxmd.com/read/28511687/polymeric-micelles-with-dual-thermal-and-reactive-oxygen-species-ros-responsiveness-for-inflammatory-cancer-cell-delivery
#9
Meiqiong Tang, Ping Hu, Qiang Zheng, Nicola Tirelli, Xiaohong Yang, Zhanlong Wang, Yanfang Wang, Qing Tang, Yun He
BACKGROUND: The object of this study was to develop a thermally and reactive oxygen species-responsive nanocarrier system for cancer therapy. RESULTS: PPS-PNIPAm block copolymer was designed and synthesised using a combination of living anionic ring-opening polymerization and atom transfer radical polymerization. The synthesized polymer formed micellar aggregates in water and demonstrated dual responsiveness towards temperature and oxidants. Using doxorubicin (DOX) as a model drug, encapsulation and in vitro release of the drug molecules in PPS-PNIPAm nanocarriers confirmed the responsive release properties of such system...
May 16, 2017: Journal of Nanobiotechnology
https://www.readbyqxmd.com/read/28482882/targeted-sirna-delivery-reduces-nitric-oxide-mediated-cell-death-after-spinal-cord-injury
#10
Wen Gao, Jianming Li
BACKGROUND: Traumatic spinal cord injury (SCI) includes the primary insult as well as a sequela of biochemical and cellular cascades that amplifies the initial injury. This degenerative process, known as secondary injury, is often mediated by both reactive oxygen and nitrogen species released from damaged cells. Previous data suggests that dysregulated production of nitric oxide via inducible nitric oxide synthase (iNOS) is detrimental to spinal cord recovery. M1 macrophages have been implicated to overexpress iNOS post-SCI...
May 8, 2017: Journal of Nanobiotechnology
https://www.readbyqxmd.com/read/28477617/tracking-single-baculovirus-retrograde-transportation-in-host-cell-via-quantum-dot-labeling-of-virus-internal-component
#11
Li Wen, Zhen-Hua Zheng, An-An Liu, Cheng Lv, Li-Juan Zhang, Jian Ao, Zhi-Ling Zhang, Han-Zhong Wang, Yi Lin, Dai-Wen Pang
BACKGROUND: Quantum dot (QD)-based single virus tracking has become a powerful tool for dissecting virus infection mechanism. However, only virus behaviors at the early stage of retrograde trafficking have been dynamically tracked so far. Monitoring of comprehensive virus retrograde transportation remains a challenge. RESULTS: Based on the superior fluorescence properties of QDs and their labeling of virus internal component, the dynamic interactions between baculoviruses and all key transportation-related cellular structures, including vesicles, acidic endosomes, actins, nuclear pores and nuclei, were visualized at the single-virus level...
May 6, 2017: Journal of Nanobiotechnology
https://www.readbyqxmd.com/read/28464873/highly-sensitive-and-accurate-detection-of-c-reactive-protein-by-cdse-zns-quantum-dot-based-fluorescence-linked-immunosorbent-assay
#12
Yanbing Lv, Ruili Wu, Kunrui Feng, Jinjie Li, Qing Mao, Hang Yuan, Huaibin Shen, Xiangdong Chai, Lin Song Li
BACKGROUND: The conventional and widely used enzyme-linked immunosorbent assays (ELISA), due to specificity and high-sensitivity, were suitable in vitro diagnosis. But enzymes are vulnerable to the external conditions, and the complex operation steps limit its application. Semiconductor quantum dots have been successfully used in biological and medical research due to the high photoluminescence and high resistance to photobleaching. In this study, we have developed a novel quantum dot-labeled immunosorbent assay for rapid disease detection of C-reactive protein (CRP)...
May 2, 2017: Journal of Nanobiotechnology
https://www.readbyqxmd.com/read/28464829/a-mechanistic-investigation-exploring-the-differential-transfection-efficiencies-between-the-easy-to-transfect-sk-br3-and-difficult-to-transfect-ct26-cell-lines
#13
Elizabeth Figueroa, Pallavi Bugga, Vishwaratn Asthana, Allen L Chen, J Stephen Yan, Emily Reiser Evans, Rebekah A Drezek
BACKGROUND: Gold-polyamidoamine (AuPAMAM) has previously been shown to successfully transfect cells with high efficiency. However, we have observed that certain cell types are more amenable to Au-PAMAM transfection than others. Here we utilized two representative cell lines-a "difficult to transfect" CT26 cell line and an "easy to transfect" SK-BR3 cell line-and attempted to determine the underlying mechanism for differential transfection in both cell types. Using a commonly established poly-cationic polymer similar to PAMAM (polyethyleneimine, or PEI), we additionally sought to quantify the relative transfection efficiencies of each vector in CT26 and SK-BR3 cells, in the hopes of elucidating any mechanistic differences that may exist between the two transfection vectors...
May 2, 2017: Journal of Nanobiotechnology
https://www.readbyqxmd.com/read/28454579/a-retro-inverso-cell-penetrating-peptide-for-sirna-delivery
#14
Anaïs Vaissière, Gudrun Aldrian, Karidia Konate, Mattias F Lindberg, Carole Jourdan, Anthony Telmar, Quentin Seisel, Frédéric Fernandez, Véronique Viguier, Coralie Genevois, Franck Couillaud, Prisca Boisguerin, Sébastien Deshayes
BACKGROUND: Small interfering RNAs (siRNAs) are powerful tools to control gene expression. However, due to their poor cellular permeability and stability, their therapeutic development requires a specific delivery system. Among them, cell-penetrating peptides (CPP) have been shown to transfer efficiently siRNA inside the cells. Recently we developed amphipathic peptides able to self-assemble with siRNAs as peptide-based nanoparticles and to transfect them into cells. However, despite the great potential of these drug delivery systems, most of them display a low resistance to proteases...
April 28, 2017: Journal of Nanobiotechnology
https://www.readbyqxmd.com/read/28446250/nanoparticles-based-on-essential-metals-and-their-phytotoxicity
#15
REVIEW
Branislav Ruttkay-Nedecky, Olga Krystofova, Lukas Nejdl, Vojtech Adam
Nanomaterials in agriculture are becoming popular due to the impressive advantages of these particles. However, their bioavailability and toxicity are key features for their massive employment. Herein, we comprehensively summarize the latest findings on the phytotoxicity of nanomaterial products based on essential metals used in plant protection. The metal nanoparticles (NPs) synthesized from essential metals belong to the most commonly manufactured types of nanomaterials since they have unique physical and chemical properties and are used in agricultural and biotechnological applications, which are discussed...
April 26, 2017: Journal of Nanobiotechnology
https://www.readbyqxmd.com/read/28438164/aggregation-dispersion-transitions-of-t4-phage-triggered-by-environmental-ion-availability
#16
Bożena Szermer-Olearnik, Marek Drab, Mateusz Mąkosa, Maria Zembala, Jakub Barbasz, Krystyna Dąbrowska, Janusz Boratyński
BACKGROUND: Bacteriophage survives in at least two extremes of ionic environments: bacterial host (high ionic-cytosol) and that of soil (low ionic-environmental water). The impact of ionic composition in the micro- and macro-environments has not so far been addressed in phage biology. RESULTS: Here, we discovered a novel mechanism of aggregation/disaggregation transitions by phage virions. When normal sodium levels in phage media (150 mM) were lowered to 10 mM, advanced imaging by scanning electron microscopy, atomic force microscopy and dynamic light scattering all revealed formation of viral packages, each containing 20-100 virions...
April 24, 2017: Journal of Nanobiotechnology
https://www.readbyqxmd.com/read/28399890/imipenem-cilastatin-encapsulated-polymeric-nanoparticles-for-destroying-carbapenem-resistant-bacterial-isolates
#17
Mona I Shaaban, Mohamed A Shaker, Fatma M Mady
BACKGROUND: Carbapenem-resistance is an extremely growing medical threat in antibacterial therapy as the incurable resistant strains easily develop a multi-resistance action to other potent antimicrobial agents. Nonetheless, the protective delivery of current antibiotics using nano-carriers opens a tremendous approach in the antimicrobial therapy, allowing the nano-formulated antibiotics to beat these health threat pathogens. Herein, we encapsulated imipenem into biodegradable polymeric nanoparticles to destroy the imipenem-resistant bacteria and overcome the microbial adhesion and dissemination...
April 11, 2017: Journal of Nanobiotechnology
https://www.readbyqxmd.com/read/28399865/toxicity-of-nano-and-ionic-silver-to-embryonic-stem-cells-a-comparative-toxicogenomic-study
#18
Xiugong Gao, Vanessa D Topping, Zachary Keltner, Robert L Sprando, Jeffrey J Yourick
BACKGROUND: The widespread application of silver nanoparticles (AgNPs) and silver-containing products has raised public safety concerns about their adverse effects on human health and the environment. To date, in vitro toxic effects of AgNPs and ionic silver (Ag(+)) on many somatic cell types are well established. However, no studies have been conducted hitherto to evaluate their effect on cellular transcriptome in embryonic stem cells (ESCs). RESULTS: The present study characterized transcriptomic changes induced by 5...
April 11, 2017: Journal of Nanobiotechnology
https://www.readbyqxmd.com/read/28399863/vectorized-nanodelivery-systems-for-ischemic-stroke-a-concept-and-a-need
#19
REVIEW
Andrés Da Silva-Candal, Bárbara Argibay, Ramón Iglesias-Rey, Zulema Vargas, Alba Vieites-Prado, Esteban López-Arias, Emilio Rodríguez-Castro, Iria López-Dequidt, Manuel Rodríguez-Yáñez, Yolanda Piñeiro, Tomás Sobrino, Francisco Campos, José Rivas, José Castillo
Neurological diseases of diverse aetiologies have significant effects on the quality of life of patients. The limited self-repairing capacity of the brain is considered to be the origin of the irreversible and progressive nature of many neurological diseases. Therefore, neuroprotection is an important goal shared by many clinical neurologists and neuroscientists. In this review, we discuss the main obstacles that have prevented the implementation of experimental neuroprotective strategies in humans and propose alternative avenues for the use of neuroprotection as a feasible therapeutic approach...
April 11, 2017: Journal of Nanobiotechnology
https://www.readbyqxmd.com/read/28399862/chitosan-nanoparticle-mediated-co-delivery-of-shatg-5-and-gefitinib-synergistically-promoted-the-efficacy-of-chemotherapeutics-through-the-modulation-of-autophagy
#20
Yan Zheng, Chang Su, Liang Zhao, Yijie Shi
BACKGROUND: Autophagy reportedly plays vital and complex roles in many diseases. During times of starvation or energy deficiency, autophagy will occur at higher levels to provide cells with the nutrients or energy necessary to survive in stressful conditions. Some anti-cancer drugs induce protective autophagy and reduce cell apoptosis. Autophagy can adversely affect apoptosis, and blocking autophagy will increase the sensitivity of cells to apoptosis signals. METHODS: We designed chitosan nanoparticles (NPs) to promote the co-delivery of gefitinib (an anti-cancer drug) and shRNA-expressing plasmid DNA that targets the Atg-5 gene (shAtg-5) as an autophagy inhibitor to improve anti-cancer effects and autophagy mediation...
April 11, 2017: Journal of Nanobiotechnology
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