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Journal of Nanobiotechnology

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https://www.readbyqxmd.com/read/28521752/synthesis-characterization-and-biological-verification-of-anti-her2-indocyanine-green-doxorubicin-loaded-polyethyleneimine-coated-perfluorocarbon-double-nanoemulsions-for-targeted-photochemotherapy-of-breast-cancer-cells
#1
Yu-Hsiang Lee, Yun-Ting Ma
BACKGROUND: Breast cancer is the most frequently diagnosed cancer and the leading cause of cancer death among females worldwide. Among various types of breast cancer, the human epidermal growth factor receptor 2 (HER2)-overexpressing breast cancer is known to be more aggressive and often resistant to medicinal treatment, leading to an insufficient prognosis and poor susceptibility to chemotherapy and/or hormonal therapy in the current clinic. These circumstances implicate that developing an improved therapeutic strategy rather than persistently changing the anticancer drugs for trying is truly needed to successfully cure this type of breast cancer...
May 18, 2017: Journal of Nanobiotechnology
https://www.readbyqxmd.com/read/28514955/label-free-biosensing-of-salmonella-enterica-serovars-at-single-cell-level
#2
Bin Wang, Bosoon Park, Bingqian Xu, Yongkuk Kwon
BACKGROUND: The emerging nanotechnologies have greatly facilitated the development of label-free biosensors. The atomic force microscopy (AFM) has been used to study the molecular mechanism of the reactions for protein and aptamers. The surface plasmon resonance (SPR) have been used in fast detections of various pathogens such as bacteria. This study used both AFM and SPR to investigate the complex reactions between aptamers and outer membrane proteins (OMPs) on the surface of S. typhimurium...
May 17, 2017: Journal of Nanobiotechnology
https://www.readbyqxmd.com/read/28511687/polymeric-micelles-with-dual-thermal-and-reactive-oxygen-species-ros-responsiveness-for-inflammatory-cancer-cell-delivery
#3
Meiqiong Tang, Ping Hu, Qiang Zheng, Nicola Tirelli, Xiaohong Yang, Zhanlong Wang, Yanfang Wang, Qing Tang, Yun He
BACKGROUND: The object of this study was to develop a thermally and reactive oxygen species-responsive nanocarrier system for cancer therapy. RESULTS: PPS-PNIPAm block copolymer was designed and synthesised using a combination of living anionic ring-opening polymerization and atom transfer radical polymerization. The synthesized polymer formed micellar aggregates in water and demonstrated dual responsiveness towards temperature and oxidants. Using doxorubicin (DOX) as a model drug, encapsulation and in vitro release of the drug molecules in PPS-PNIPAm nanocarriers confirmed the responsive release properties of such system...
May 16, 2017: Journal of Nanobiotechnology
https://www.readbyqxmd.com/read/28482882/targeted-sirna-delivery-reduces-nitric-oxide-mediated-cell-death-after-spinal-cord-injury
#4
Wen Gao, Jianming Li
BACKGROUND: Traumatic spinal cord injury (SCI) includes the primary insult as well as a sequela of biochemical and cellular cascades that amplifies the initial injury. This degenerative process, known as secondary injury, is often mediated by both reactive oxygen and nitrogen species released from damaged cells. Previous data suggests that dysregulated production of nitric oxide via inducible nitric oxide synthase (iNOS) is detrimental to spinal cord recovery. M1 macrophages have been implicated to overexpress iNOS post-SCI...
May 8, 2017: Journal of Nanobiotechnology
https://www.readbyqxmd.com/read/28477617/tracking-single-baculovirus-retrograde-transportation-in-host-cell-via-quantum-dot-labeling-of-virus-internal-component
#5
Li Wen, Zhen-Hua Zheng, An-An Liu, Cheng Lv, Li-Juan Zhang, Jian Ao, Zhi-Ling Zhang, Han-Zhong Wang, Yi Lin, Dai-Wen Pang
BACKGROUND: Quantum dot (QD)-based single virus tracking has become a powerful tool for dissecting virus infection mechanism. However, only virus behaviors at the early stage of retrograde trafficking have been dynamically tracked so far. Monitoring of comprehensive virus retrograde transportation remains a challenge. RESULTS: Based on the superior fluorescence properties of QDs and their labeling of virus internal component, the dynamic interactions between baculoviruses and all key transportation-related cellular structures, including vesicles, acidic endosomes, actins, nuclear pores and nuclei, were visualized at the single-virus level...
May 6, 2017: Journal of Nanobiotechnology
https://www.readbyqxmd.com/read/28464873/highly-sensitive-and-accurate-detection-of-c-reactive-protein-by-cdse-zns-quantum-dot-based-fluorescence-linked-immunosorbent-assay
#6
Yanbing Lv, Ruili Wu, Kunrui Feng, Jinjie Li, Qing Mao, Hang Yuan, Huaibin Shen, Xiangdong Chai, Lin Song Li
BACKGROUND: The conventional and widely used enzyme-linked immunosorbent assays (ELISA), due to specificity and high-sensitivity, were suitable in vitro diagnosis. But enzymes are vulnerable to the external conditions, and the complex operation steps limit its application. Semiconductor quantum dots have been successfully used in biological and medical research due to the high photoluminescence and high resistance to photobleaching. In this study, we have developed a novel quantum dot-labeled immunosorbent assay for rapid disease detection of C-reactive protein (CRP)...
May 2, 2017: Journal of Nanobiotechnology
https://www.readbyqxmd.com/read/28464829/a-mechanistic-investigation-exploring-the-differential-transfection-efficiencies-between-the-easy-to-transfect-sk-br3-and-difficult-to-transfect-ct26-cell-lines
#7
Elizabeth Figueroa, Pallavi Bugga, Vishwaratn Asthana, Allen L Chen, J Stephen Yan, Emily Reiser Evans, Rebekah A Drezek
BACKGROUND: Gold-polyamidoamine (AuPAMAM) has previously been shown to successfully transfect cells with high efficiency. However, we have observed that certain cell types are more amenable to Au-PAMAM transfection than others. Here we utilized two representative cell lines-a "difficult to transfect" CT26 cell line and an "easy to transfect" SK-BR3 cell line-and attempted to determine the underlying mechanism for differential transfection in both cell types. Using a commonly established poly-cationic polymer similar to PAMAM (polyethyleneimine, or PEI), we additionally sought to quantify the relative transfection efficiencies of each vector in CT26 and SK-BR3 cells, in the hopes of elucidating any mechanistic differences that may exist between the two transfection vectors...
May 2, 2017: Journal of Nanobiotechnology
https://www.readbyqxmd.com/read/28454579/a-retro-inverso-cell-penetrating-peptide-for-sirna-delivery
#8
Anaïs Vaissière, Gudrun Aldrian, Karidia Konate, Mattias F Lindberg, Carole Jourdan, Anthony Telmar, Quentin Seisel, Frédéric Fernandez, Véronique Viguier, Coralie Genevois, Franck Couillaud, Prisca Boisguerin, Sébastien Deshayes
BACKGROUND: Small interfering RNAs (siRNAs) are powerful tools to control gene expression. However, due to their poor cellular permeability and stability, their therapeutic development requires a specific delivery system. Among them, cell-penetrating peptides (CPP) have been shown to transfer efficiently siRNA inside the cells. Recently we developed amphipathic peptides able to self-assemble with siRNAs as peptide-based nanoparticles and to transfect them into cells. However, despite the great potential of these drug delivery systems, most of them display a low resistance to proteases...
April 28, 2017: Journal of Nanobiotechnology
https://www.readbyqxmd.com/read/28446250/nanoparticles-based-on-essential-metals-and-their-phytotoxicity
#9
REVIEW
Branislav Ruttkay-Nedecky, Olga Krystofova, Lukas Nejdl, Vojtech Adam
Nanomaterials in agriculture are becoming popular due to the impressive advantages of these particles. However, their bioavailability and toxicity are key features for their massive employment. Herein, we comprehensively summarize the latest findings on the phytotoxicity of nanomaterial products based on essential metals used in plant protection. The metal nanoparticles (NPs) synthesized from essential metals belong to the most commonly manufactured types of nanomaterials since they have unique physical and chemical properties and are used in agricultural and biotechnological applications, which are discussed...
April 26, 2017: Journal of Nanobiotechnology
https://www.readbyqxmd.com/read/28438164/aggregation-dispersion-transitions-of-t4-phage-triggered-by-environmental-ion-availability
#10
Bożena Szermer-Olearnik, Marek Drab, Mateusz Mąkosa, Maria Zembala, Jakub Barbasz, Krystyna Dąbrowska, Janusz Boratyński
BACKGROUND: Bacteriophage survives in at least two extremes of ionic environments: bacterial host (high ionic-cytosol) and that of soil (low ionic-environmental water). The impact of ionic composition in the micro- and macro-environments has not so far been addressed in phage biology. RESULTS: Here, we discovered a novel mechanism of aggregation/disaggregation transitions by phage virions. When normal sodium levels in phage media (150 mM) were lowered to 10 mM, advanced imaging by scanning electron microscopy, atomic force microscopy and dynamic light scattering all revealed formation of viral packages, each containing 20-100 virions...
April 24, 2017: Journal of Nanobiotechnology
https://www.readbyqxmd.com/read/28399890/imipenem-cilastatin-encapsulated-polymeric-nanoparticles-for-destroying-carbapenem-resistant-bacterial-isolates
#11
Mona I Shaaban, Mohamed A Shaker, Fatma M Mady
BACKGROUND: Carbapenem-resistance is an extremely growing medical threat in antibacterial therapy as the incurable resistant strains easily develop a multi-resistance action to other potent antimicrobial agents. Nonetheless, the protective delivery of current antibiotics using nano-carriers opens a tremendous approach in the antimicrobial therapy, allowing the nano-formulated antibiotics to beat these health threat pathogens. Herein, we encapsulated imipenem into biodegradable polymeric nanoparticles to destroy the imipenem-resistant bacteria and overcome the microbial adhesion and dissemination...
April 11, 2017: Journal of Nanobiotechnology
https://www.readbyqxmd.com/read/28399865/toxicity-of-nano-and-ionic-silver-to-embryonic-stem-cells-a-comparative-toxicogenomic-study
#12
Xiugong Gao, Vanessa D Topping, Zachary Keltner, Robert L Sprando, Jeffrey J Yourick
BACKGROUND: The widespread application of silver nanoparticles (AgNPs) and silver-containing products has raised public safety concerns about their adverse effects on human health and the environment. To date, in vitro toxic effects of AgNPs and ionic silver (Ag(+)) on many somatic cell types are well established. However, no studies have been conducted hitherto to evaluate their effect on cellular transcriptome in embryonic stem cells (ESCs). RESULTS: The present study characterized transcriptomic changes induced by 5...
April 11, 2017: Journal of Nanobiotechnology
https://www.readbyqxmd.com/read/28399863/vectorized-nanodelivery-systems-for-ischemic-stroke-a-concept-and-a-need
#13
REVIEW
Andrés Da Silva-Candal, Bárbara Argibay, Ramón Iglesias-Rey, Zulema Vargas, Alba Vieites-Prado, Esteban López-Arias, Emilio Rodríguez-Castro, Iria López-Dequidt, Manuel Rodríguez-Yáñez, Yolanda Piñeiro, Tomás Sobrino, Francisco Campos, José Rivas, José Castillo
Neurological diseases of diverse aetiologies have significant effects on the quality of life of patients. The limited self-repairing capacity of the brain is considered to be the origin of the irreversible and progressive nature of many neurological diseases. Therefore, neuroprotection is an important goal shared by many clinical neurologists and neuroscientists. In this review, we discuss the main obstacles that have prevented the implementation of experimental neuroprotective strategies in humans and propose alternative avenues for the use of neuroprotection as a feasible therapeutic approach...
April 11, 2017: Journal of Nanobiotechnology
https://www.readbyqxmd.com/read/28399862/chitosan-nanoparticle-mediated-co-delivery-of-shatg-5-and-gefitinib-synergistically-promoted-the-efficacy-of-chemotherapeutics-through-the-modulation-of-autophagy
#14
Yan Zheng, Chang Su, Liang Zhao, Yijie Shi
BACKGROUND: Autophagy reportedly plays vital and complex roles in many diseases. During times of starvation or energy deficiency, autophagy will occur at higher levels to provide cells with the nutrients or energy necessary to survive in stressful conditions. Some anti-cancer drugs induce protective autophagy and reduce cell apoptosis. Autophagy can adversely affect apoptosis, and blocking autophagy will increase the sensitivity of cells to apoptosis signals. METHODS: We designed chitosan nanoparticles (NPs) to promote the co-delivery of gefitinib (an anti-cancer drug) and shRNA-expressing plasmid DNA that targets the Atg-5 gene (shAtg-5) as an autophagy inhibitor to improve anti-cancer effects and autophagy mediation...
April 11, 2017: Journal of Nanobiotechnology
https://www.readbyqxmd.com/read/28388905/biodistribution-of-arctigenin-loaded-nanoparticles-designed-for-multimodal-imaging
#15
Qingxin Cui, Yuanyuan Hou, Yanan Wang, Xu Li, Yang Liu, Xiaoyao Ma, Zengyong Wang, Weiya Wang, Jin Tao, Qian Wang, Min Jiang, Dongyan Chen, Xizeng Feng, Gang Bai
BACKGROUND: Tracking targets of natural products is one of the most challenging issues in fields ranging from pharmacognosy to biomedicine. It is widely recognized that the biocompatible nanoparticle (NP) could function as a "key" that opens the target "lock". RESULTS: We report a functionalized poly-lysine NP technique that can monitor the target protein of arctigenin (ATG) in vivo non-invasively. The NPs were synthesized, and their morphologies and surface chemical properties were characterized by transmission electron microscopy (TEM), laser particle size analysis and atomic force microscopy (AFM)...
April 7, 2017: Journal of Nanobiotechnology
https://www.readbyqxmd.com/read/28376812/multi-walled-carbon-nanotubes-functionalized-with-recombinant-dengue-virus-3-envelope-proteins-induce-significant-and-specific-immune-responses-in-mice
#16
Alice F Versiani, Ruiz G Astigarraga, Eliseu S O Rocha, Ana Paula M Barboza, Erna G Kroon, Milene A Rachid, Daniele G Souza, Luiz O Ladeira, Edel F Barbosa-Stancioli, Ado Jorio, Flávio G Da Fonseca
BACKGROUND: Dengue is the most prevalent arthropod-borne viral disease in the world. In this article we present results on the development, characterization and immunogenic evaluation of an alternative vaccine candidate against Dengue. METHODS: The MWNT-DENV3E nanoconjugate was developed by covalent functionalization of carboxylated multi-walled carbon nanotubes (MWNT) with recombinant dengue envelope (DENV3E) proteins. The recombinant antigens were bound to the MWNT using a diimide-activated amidation process and the immunogen was characterized by TEM, AFM and Raman Spectroscopy...
April 4, 2017: Journal of Nanobiotechnology
https://www.readbyqxmd.com/read/28359284/development-of-nanoparticle-based-optical-sensors-for-pathogenic-bacterial-detection
#17
REVIEW
Teodora Mocan, Cristian T Matea, Teodora Pop, Ofelia Mosteanu, Anca Dana Buzoianu, Cosmin Puia, Cornel Iancu, Lucian Mocan
BACKGROUND: Pathogenic bacteria contribute to various globally important diseases, killing millions of people each year. Various fields of medicine currently benefit from or may potentially benefit from the use of nanotechnology applications, in which there is growing interest. Disease-related biomarkers can be rapidly and directly detected by nanostructures, such as nanowires, nanotubes, nanoparticles, cantilevers, microarrays, and nanoarrays, as part of an accurate process characterized by lower sample consumption and considerably higher sensitivity...
March 31, 2017: Journal of Nanobiotechnology
https://www.readbyqxmd.com/read/28356160/optimizing-conditions-for-labeling-of-mesenchymal-stromal-cells-mscs-with-gold-nanoparticles-a-prerequisite-for-in-vivo-tracking-of-mscs
#18
Philipp Nold, Raimo Hartmann, Neus Feliu, Karsten Kantner, Mahmoud Gamal, Beatriz Pelaz, Jonas Hühn, Xing Sun, Philipp Jungebluth, Pablo Del Pino, Holger Hackstein, Paolo Macchiarini, Wolfgang J Parak, Cornelia Brendel
BACKGROUND: Mesenchymal stromal cells (MSCs) have an inherent migratory capacity towards tumor tissue in vivo. With the future objective to quantify the tumor homing efficacy of MSCs, as first step in this direction we investigated the use of inorganic nanoparticles (NPs), in particular ca. 4 nm-sized Au NPs, for MSC labeling. Time dependent uptake efficiencies of NPs at different exposure concentrations and times were determined via inductively coupled plasma mass spectrometry (ICP-MS)...
March 29, 2017: Journal of Nanobiotechnology
https://www.readbyqxmd.com/read/28330480/real-time-label-free-monitoring-of-cell-viability-based-on-cell-adhesion-measurements-with-an-atomic-force-microscope
#19
Fang Yang, René Riedel, Pablo Del Pino, Beatriz Pelaz, Alaa Hassan Said, Mahmoud Soliman, Shashank R Pinnapireddy, Neus Feliu, Wolfgang J Parak, Udo Bakowsky, Norbert Hampp
BACKGROUND: The adhesion of cells to an oscillating cantilever sensitively influences the oscillation amplitude at a given frequency. Even early stages of cytotoxicity cause a change in the viscosity of the cell membrane and morphology, both affecting their adhesion to the cantilever. We present a generally applicable method for real-time, label free monitoring and fast-screening technique to assess early stages of cytotoxicity recorded in terms of loss of cell adhesion. RESULTS: We present data taken from gold nanoparticles of different sizes and surface coatings as well as some reference substances like ethanol, cadmium chloride, and staurosporine...
March 22, 2017: Journal of Nanobiotechnology
https://www.readbyqxmd.com/read/28327191/real-time-in-vivo-monitoring-of-magnetic-nanoparticles-in-the-bloodstream-by-ac-biosusceptometry
#20
André G Próspero, Caio C Quini, Andris F Bakuzis, Patrícia Fidelis-de-Oliveira, Gustavo M Moretto, Fábio P F Mello, Marcos F F Calabresi, Ronaldo V R Matos, Ednaldo A Zandoná, Nícholas Zufelato, Ricardo B Oliveira, José R A Miranda
BACKGROUND: We introduce and demonstrate that the AC biosusceptometry (ACB) technique enables real-time monitoring of magnetic nanoparticles (MNPs) in the bloodstream. We present an ACB system as a simple, portable, versatile, non-invasive, and accessible tool to study pharmacokinetic parameters of MNPs, such as circulation time, in real time. We synthesized and monitored manganese doped iron oxide nanoparticles in the bloodstream of Wistar rats using two different injection protocols...
March 21, 2017: Journal of Nanobiotechnology
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