journal
MENU ▼
Read by QxMD icon Read
search

Journal of Nanobiotechnology

journal
https://www.readbyqxmd.com/read/29331149/correction-to-entrapment-of-an-egfr-inhibitor-into-nanostructured-lipid-carriers-nlc-improves-its-antitumor-activity-against-human-hepatocarcinoma-cells
#1
Roberto Di Gesù, Maria Luisa Bondì, Antonina Azzolina, Emanuela Fabiola Craparo, Chiara Botto, Erika Amore, Gaetano Giammona, Melchiorre Cervello
Following publication of our article [1], we became aware that Roberto Di Gesù had been omitted from the list of authors. The corrected author list and authors' contribution statement appear below. We apologize for any inconvenience this may have caused.
January 13, 2018: Journal of Nanobiotechnology
https://www.readbyqxmd.com/read/29321058/graphene-oxide-conjugated-with-polymers-a-study-of-culture-condition-to-determine-whether-a-bacterial-growth-stimulant-or-an-antimicrobial-agent
#2
Ping-Ching Wu, Hua-Han Chen, Shih-Yao Chen, Wen-Lung Wang, Kun-Lin Yang, Chia-Hung Huang, Hui-Fang Kao, Jui-Cheng Chang, Chih-Li Lilian Hsu, Jiu-Yao Wang, Ting-Mao Chou, Wen-Shuo Kuo
BACKGROUND: The results showed that the deciding factor is the culture medium in which the bacteria and the graphene oxide (GO) are incubated at the initial manipulation step. These findings allow better use of GO and GO-based materials more and be able to clearly apply them in the field of biomedical nanotechnology. RESULTS: To study the use of GO sheets applied in the field of biomedical nanotechnology, this study determines whether GO-based materials [GO, GO-polyoxyalkyleneamine (POAA), and GO-chitosan] stimulate or inhibit bacterial growth in detail...
January 10, 2018: Journal of Nanobiotechnology
https://www.readbyqxmd.com/read/29321021/silver-pig-skin-nanocomposites-and-mesenchymal-stem-cells-suitable-antibiofilm-cellular-dressings-for-wound-healing
#3
Mario Alberto Pérez-Díaz, Phaedra Silva-Bermudez, Binisa Jiménez-López, Valentín Martínez-López, Yaaziel Melgarejo-Ramírez, Ana Brena-Molina, Clemente Ibarra, Isabel Baeza, M Esther Martínez-Pardo, M Lourdes Reyes-Frías, Erik Márquez-Gutiérrez, Cristina Velasquillo, Gabriel Martínez-Castañon, Fidel Martinez-Gutierrez, Roberto Sánchez-Sánchez
BACKGROUND: Treatment of severe or chronic skin wounds is an important challenge facing medicine and a significant health care burden. Proper wound healing is often affected by bacterial infection; where biofilm formation is one of the main risks and particularly problematic because it confers protection to microorganisms against antibiotics. One avenue to prevent bacterial colonization of wounds is the use of silver nanoparticles (AgNPs); which have proved to be effective against non-multidrug-resistant and multidrug-resistant bacteria...
January 10, 2018: Journal of Nanobiotechnology
https://www.readbyqxmd.com/read/29262862/selenium-nanoparticles-loaded-chitosan-citrate-complex-and-its-protection-against-oxidative-stress-in-d-galactose-induced-aging-mice
#4
Kaikai Bai, Bihong Hong, Zhuan Hong, Jipeng Sun, Changsen Wang
BACKGROUND: Selenium (Se) is an indispensable trace element required for animals and humans, and extra Se-supplement is necessary, especially for those having Se deficiency. Recently, selenium nanoparticles (SeNPs), as a special form of Se supplement, have attracted worldwide attention due to their distinguished properties and excellent bioactivities. In this present study, an eco-friendly and economic way to prepare stable SeNPs was introduced. SeNPs were synthesized in the presence of chitosan (CTS) and then embedded into chitosan/citrate gel, generating selenium nanoparticles-loaded chitosan/citrate complex (SeNPs-C/C)...
December 20, 2017: Journal of Nanobiotechnology
https://www.readbyqxmd.com/read/29258613/dual-drug-loaded-nanoneedles-with-targeting-property-for-efficient-cancer-therapy
#5
Xiangrui Yang, Shichao Wu, Wanyi Xie, Anran Cheng, Lichao Yang, Zhenqing Hou, Xin Jin
BACKGROUND: Since the anticancer drugs have diverse inhibited mechanisms to the cancer cells, the use of two or more kinds of anticancer agents may achieve excellent therapeutic effects, especially to the drug-resistant tumors. RESULTS: In this study, we developed a kind of dual drug [methotrexate (MTX) and 10-hydroxycamptothecine (HCPT)] loaded nanoneedles (DDNDs) with pronounced targeting property, high drug loading and prolonged drug release. The anti-solvent precipitation of the HCPT and MTX modified PEG-b-PLGA (PEG-b-PLGA-MTX, PPMTX) leads to nucleation of nanoneedles with nanocrystalline HCPT as the core wrapped with PPMTX as steric stabilizers...
December 19, 2017: Journal of Nanobiotechnology
https://www.readbyqxmd.com/read/29246155/zno-nanoparticles-modulate-the-ionic-transport-and-voltage-regulation-of-lysenin-nanochannels
#6
Sheenah L Bryant, Josh E Eixenberger, Steven Rossland, Holly Apsley, Connor Hoffmann, Nisha Shrestha, Michael McHugh, Alex Punnoose, Daniel Fologea
BACKGROUND: The insufficient understanding of unintended biological impacts from nanomaterials (NMs) represents a serious impediment to their use for scientific, technological, and medical applications. While previous studies have focused on understanding nanotoxicity effects mostly resulting from cellular internalization, recent work indicates that NMs may interfere with transmembrane transport mechanisms, hence enabling contributions to nanotoxicity by affecting key biological activities dependent on transmembrane transport...
December 16, 2017: Journal of Nanobiotechnology
https://www.readbyqxmd.com/read/29233187/graphene-based-dental-adhesive-with-anti-biofilm-activity
#7
Agnese Bregnocchi, Elena Zanni, Daniela Uccelletti, Fabrizio Marra, Domenico Cavallini, Francesca De Angelis, Giovanni De Bellis, Maurizio Bossù, Gaetano Ierardo, Antonella Polimeni, Maria Sabrina Sarto
BACKGROUND: Secondary caries are considered the main cause of dental restoration failure. In this context, anti-biofilm and bactericidal properties are desired in dental materials against pathogens such as Streptococcus mutans. To this purpose, graphene based materials can be used as fillers of polymer dental adhesives. In this work, we investigated the possibility to use as filler of dental adhesives, graphene nanoplatelets (GNP), a non toxic hydrophobic nanomaterial with antimicrobial and anti-biofilm properties...
December 12, 2017: Journal of Nanobiotechnology
https://www.readbyqxmd.com/read/29202753/development-of-triptolide-nanoemulsion-gels-for-percutaneous-administration-physicochemical-transport-pharmacokinetic-and-pharmacodynamic-characteristics
#8
Meng Yang, Yongwei Gu, Dishun Yang, Xiaomeng Tang, Jiyong Liu
BACKGROUND: This work aimed to provide useful information on the use of nanoemulsions for the percutaneous administration of triptolide. Lipid nanosystems have great potential for transdermal drug delivery. Nanoemulsions and nanoemulsion gels were prepared to enhance percutaneous permeation. Microstructure and in vitro/in vivo percutaneous delivery characteristics of triptolide (TPL)-nanoemulsions and TPL-nanoemulsion gels were compared. The integrity of the nanoemulsions and nanoemulsion gels during transdermal delivery and its effects on the surface of skin were also investigated...
December 4, 2017: Journal of Nanobiotechnology
https://www.readbyqxmd.com/read/29179722/aminoglucose-functionalized-redox-responsive-polymer-nanomicelles-for-overcoming-chemoresistance-in-lung-cancer-cells
#9
Yi Zhou, Huaying Wen, Liang Gu, Jijun Fu, Jiayi Guo, Lingran Du, Xiaoqin Zhou, Xiyong Yu, Yugang Huang, He Wang
BACKGROUND: Chemotherapeutic drugs used for cancer therapy frequently encounter multiple-drug resistance (MDR). Nanoscale carriers that can target tumors to accumulate and release drugs intracellularly have the greatest potential for overcoming MDR. Glucose transporter-1 (GLUT-1) and glutathione (GSH) overexpression in cancer cells was exploited to assemble aminoglucose (AG)-conjugated, redox-responsive nanomicelles from a single disulfide bond-bridged block polymer of polyethylene glycol and polylactic acid (AG-PEG-SS-PLA)...
November 28, 2017: Journal of Nanobiotechnology
https://www.readbyqxmd.com/read/29166921/identification-of-epidermal-growth-factor-receptor-positive-glioblastoma-using-lipid-encapsulated-targeted-superparamagnetic-iron-oxide-nanoparticles-in-vitro
#10
Huai-Lu Chen, Fei-Ting Hsu, Yu-Chieh Jill Kao, Hua-Shan Liu, Wan-Zhen Huang, Chia-Feng Lu, Ping-Huei Tsai, Ahmed Atef Ahmed Ali, Gilbert Aaron Lee, Ray-Jade Chen, Cheng-Yu Chen
BACKGROUND: Targeted superparamagnetic iron oxide (SPIO) nanoparticles have emerged as a promising biomarker detection tool for molecular magnetic resonance (MR) image diagnosis. To identify patients who could benefit from Epidermal growth factor receptor (EGFR)-targeted therapies, we introduce lipid-encapsulated SPIO nanoparticles and hypothesized that anti-EGFR antibody cetuximab conjugated of such nanoparticles can be used to identify EGFR-positive glioblastomas in non-invasive T2 MR image assays...
November 22, 2017: Journal of Nanobiotechnology
https://www.readbyqxmd.com/read/29162137/potentiating-angiogenesis-arrest-in-vivo-via-laser-irradiation-of-peptide-functionalised-gold-nanoparticles
#11
Pedro Pedrosa, Amelie Heuer-Jungemann, Antonios G Kanaras, Alexandra R Fernandes, Pedro V Baptista
BACKGROUND: Anti-angiogenic therapy has great potential for cancer therapy with several FDA approved formulations but there are considerable side effects upon the normal blood vessels that decrease the potential application of such therapeutics. Chicken chorioallantoic membrane (CAM) has been used as a model to study angiogenesis in vivo. Using a CAM model, it had been previously shown that spherical gold nanoparticles functionalised with an anti-angiogenic peptide can humper neo-angiogenesis...
November 21, 2017: Journal of Nanobiotechnology
https://www.readbyqxmd.com/read/29157261/role-of-omics-techniques-in-the-toxicity-testing-of-nanoparticles
#12
REVIEW
Eleonore Fröhlich
Nanotechnology is regarded as a key technology of the twenty-first century. Despite the many advantages of nanotechnology it is also known that engineered nanoparticles (NPs) may cause adverse health effects in humans. Reports on toxic effects of NPs relay mainly on conventional (phenotypic) testing but studies of changes in epigenome, transcriptome, proteome, and metabolome induced by NPs have also been performed. NPs most relevant for human exposure in consumer, health and food products are metal, metal oxide and carbon-based NPs...
November 21, 2017: Journal of Nanobiotechnology
https://www.readbyqxmd.com/read/29149896/liposomal-vaccine-formulations-as-prophylactic-agents-design-considerations-for-modern-vaccines
#13
REVIEW
Luis O De Serrano, David J Burkhart
Vaccinology is one of the most important cornerstones in modern medicine, providing better quality of life. The human immune system is composed of innate and adaptive immune processes that interplay when infection occurs. Innate immunity relies on pathogen-associated molecular patterns which are recognized by pathogen recognition receptors localized in antigen presenting cells. After antigen processing and presentation, CD4(+) T cell polarization occurs, further leading to B cell and CD8(+) activation and humoral and cell-mediated adaptive immune responses...
November 17, 2017: Journal of Nanobiotechnology
https://www.readbyqxmd.com/read/29137640/direct-reprogramming-of-mouse-fibroblasts-into-neural-cells-via-porphyra-yezoensis-polysaccharide-based-high-efficient-gene-co-delivery
#14
Qingtong Yu, Jingjing Chen, Wenwen Deng, Xia Cao, Yan Wang, Jie Zhou, Wenqian Xu, Pan Du, Qiang Wang, Jiangnan Yu, Ximing Xu
BACKGROUND: The cell source for transplantation therapy is always a prerequisite question to be solved in clinical applications. Neural cells are considered non-regenerable, which highly restrict their application in the treatment for nerve injury. Therefore, neural trans-differentiation based on gene transfection provides a new solution to this issue. Compared to viral strategy, non-viral gene delivery systems are considered as a more promising way to achieve this aim. This study centers on a novel application of Porphyra yezoensis polysaccharide as a non-viral gene carrier for the neural trans-differentiation of mouse fibroblasts...
November 14, 2017: Journal of Nanobiotechnology
https://www.readbyqxmd.com/read/29132385/aptamer-selection-and-applications-for-breast-cancer-diagnostics-and-therapy
#15
REVIEW
Mei Liu, Xiaocheng Yu, Zhu Chen, Tong Yang, Dandan Yang, Qianqian Liu, Keke Du, Bo Li, Zhifei Wang, Song Li, Yan Deng, Nongyue He
Aptamers are short non-coding, single-stranded oligonucleotides (RNA or DNA) developed through Systematic Evolution of Ligands by Exponential enrichment (SELEX) in vitro. Similar to antibodies, aptamers can bind to specific targets with high affinity, and are considered promising therapeutic agents as they have several advantages over antibodies, including high specificity, stability, and non-immunogenicity. Furthermore, aptamers can be produced at a low cost and easily modified, and are, therefore, called "chemical antibodies"...
November 13, 2017: Journal of Nanobiotechnology
https://www.readbyqxmd.com/read/29126419/the-adverse-vascular-effects-of-multi-walled-carbon-nanotubes-mwcnts-to-human-vein-endothelial-cells-huvecs-in-vitro-role-of-length-of-mwcnts
#16
Jimin Long, Yafang Xiao, Liangliang Liu, Yi Cao
BACKGROUND: Increasing evidences indicate that exposure to multi-walled carbon nanotubes (MWCNTs) could induce adverse vascular effects, but the role of length of MWCNTs in determining the toxic effects is less studied. This study investigated the adverse effects of two well-characterized MWCNTs to human umbilical vein endothelial cells (HUVECs). METHODS: The internalization and localization of MWCNTs in HUVECs were examined by using transmission electron microscopy (TEM)...
November 10, 2017: Journal of Nanobiotechnology
https://www.readbyqxmd.com/read/29121949/quantifying-engineered-nanomaterial-toxicity-comparison-of-common-cytotoxicity-and-gene-expression-measurements
#17
Donald H Atha, Amber Nagy, Andrea Steinbrück, Allison M Dennis, Jennifer A Hollingsworth, Varsha Dua, Rashi Iyer, Bryant C Nelson
BACKGROUND: When evaluating the toxicity of engineered nanomaterials (ENMS) it is important to use multiple bioassays based on different mechanisms of action. In this regard we evaluated the use of gene expression and common cytotoxicity measurements using as test materials, two selected nanoparticles with known differences in toxicity, 5 nm mercaptoundecanoic acid (MUA)-capped InP and CdSe quantum dots (QDs). We tested the effects of these QDs at concentrations ranging from 0.5 to 160 µg/mL on cultured normal human bronchial epithelial (NHBE) cells using four common cytotoxicity assays: the dichlorofluorescein assay for reactive oxygen species (ROS), the lactate dehydrogenase assay for membrane viability (LDH), the mitochondrial dehydrogenase assay for mitochondrial function, and the Comet assay for DNA strand breaks...
November 9, 2017: Journal of Nanobiotechnology
https://www.readbyqxmd.com/read/29121930/buckyballs-conjugated-with-nucleic-acid-sequences-identifies-microorganisms-in-live-cell-assays
#18
Qingsu Cheng, Bahram Parvin
BACKGROUND: Rapid identification of bacteria can play an important role at the point of care, evaluating the health of the ecosystem, and discovering spatiotemporal distributions of a bacterial community. We introduce a method for rapid identification of bacteria in live cell assays based on cargo delivery of a nucleic acid sequence and demonstrate how a mixed culture can be differentiated using a simple microfluidic system. METHODS: C60 Buckyballs are functionalized with nucleic acid sequences and a fluorescent reporter to show that a diversity of microorganisms can be detected and identified in live cell assays...
November 9, 2017: Journal of Nanobiotechnology
https://www.readbyqxmd.com/read/29100510/antimicrobial-effects-of-zero-valent-iron-nanoparticles-on-gram-positive-bacillus-strains-and-gram-negative-escherichia-coli-strains
#19
Yi-Huang Hsueh, Ping-Han Tsai, Kuen-Song Lin, Wan-Ju Ke, Chao-Lung Chiang
BACKGROUND: Zero-valent iron nanoparticles (ZVI NPs) have been used extensively for the remediation of contaminated soil and groundwater. Owing to their large active surface area, they serve as strong and effective reductants. However, the ecotoxicity and bioavailability of ZVI NPs in diverse ecological media have not been evaluated in detail and most studies have focused on non-nano ZVI or Fe(0). In addition, the antimicrobial properties of ZVI NPs have rarely been investigated, and the underlying mechanism of their toxicity remains unknown...
November 3, 2017: Journal of Nanobiotechnology
https://www.readbyqxmd.com/read/29078797/dual-stimuli-responsive-fe3o4-graft-poly-acrylic-acid-block-poly-2-methacryloyloxyethyl-ferrocenecarboxylate-copolymer-micromicelles-surface-raft-synthesis-self-assembly-and-drug-release-applications
#20
Yuan Wang, Xue-Yin Zhang, Yan-Ling Luo, Feng Xu, Ya-Shao Chen, Yu-Yu Su
BACKGROUND: Stimuli-responsive polymer materials are a new kind of intelligent materials based on the concept of bionics, which exhibits more significant changes in physicochemical properties upon triggered by tiny environment stimuli, hence providing a good carrier platform for antitumor drug delivery. RESULTS: Dual stimuli-responsive Fe3O4 graft poly(acrylic acid)-block-poly(2-methacryloyloxyethyl ferrocenecarboxylate) block copolymers (Fe3O4-g-PAA-b-PMAEFC) were engineered and synthesized through a two-step sequential reversible addition-fragmentation chain transfer polymerization route...
October 27, 2017: Journal of Nanobiotechnology
journal
journal
40256
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"