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Journal of Nanobiotechnology

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https://www.readbyqxmd.com/read/28086894/c60-fullerene-as-promising-therapeutic-agent-for-correcting-and-preventing-skeletal-muscle-fatigue
#1
Yurij I Prylutskyy, Inna V Vereshchaka, Andriy V Maznychenko, Nataliya V Bulgakova, Olga O Gonchar, Olena A Kyzyma, Uwe Ritter, Peter Scharff, Tomasz Tomiak, Dmytro M Nozdrenko, Iryna V Mishchenko, Alexander I Kostyukov
BACKGROUND: Bioactive soluble carbon nanostructures, such as the C60 fullerene can bond with up to six electrons, thus serving by a powerful scavenger of reactive oxygen species similarly to many natural antioxidants, widely used to decrease the muscle fatigue effects. The aim of the study is to define action of the pristine C60 fullerene aqueous colloid solution (C60FAS), on the post-fatigue recovering of m. triceps surae in anaesthetized rats. RESULTS: During fatigue development, we observed decrease in the muscle effort level before C60FAS administration...
January 13, 2017: Journal of Nanobiotechnology
https://www.readbyqxmd.com/read/28068992/hyaluronic-acid-coated-chitosan-nanoparticles-induce-ros-mediated-tumor-cell-apoptosis-and-enhance-antitumor-efficiency-by-targeted-drug-delivery-via-cd44
#2
Tao Wang, Jiahui Hou, Chang Su, Liang Zhao, Yijie Shi
BACKGROUND: A targeted drug nanoparticle (NP) delivery system has shown potential as a possible cancer treatment. Given its merits, such as its selective distribution at tumor sites and its controllable drug release, drug-loaded NPs can be effectively delivered to selected organs and targeted cells, thus enhancing its antitumor efficiency and reducing its toxicity. METHODS: We reported that hyaluronic acid (HA)-coated chitosan NPs promoted the drug delivery of 5-fluorouracil (5-Fu) into tumor cells that highly expressed CD44...
January 10, 2017: Journal of Nanobiotechnology
https://www.readbyqxmd.com/read/28069025/interaction-of-biomedical-nanoparticles-with-the-pulmonary-immune-system
#3
REVIEW
Fabian Blank, Kleanthis Fytianos, Emilie Seydoux, Laura Rodriguez-Lorenzo, Alke Petri-Fink, Christophe von Garnier, Barbara Rothen-Rutishauser
Engineered nanoparticles (NPs) offer site-specific delivery, deposition and cellular uptake due to their unique physicochemical properties and were shown to modulate immune responses. The respiratory tract with its vast surface area is an attractive target organ for innovative immunomodulatory therapeutic applications by pulmonary administration of such NPs, enabling interactions with resident antigen-presenting cells (APCs), such as dendritic cells and macrophages. Depending on the respiratory tract compartment, e...
January 9, 2017: Journal of Nanobiotechnology
https://www.readbyqxmd.com/read/28061858/cytotoxic-effects-of-nanosilver-are-highly-dependent-on-the-chloride-concentration-and-the-presence-of-organic-compounds-in-the-cell-culture-media
#4
Jean-Pierre Kaiser, Matthias Roesslein, Liliane Diener, Adrian Wichser, Bernd Nowack, Peter Wick
BACKGROUND: Nanosilver shows great promise for use in industrial, consumer or medical products because of its antimicrobial properties. However, the underlying mechanisms of the effects of silver nanoparticles on human cells are still controversial. Therefore, in the present study the influence of the chloride concentration and different serum content of culture media on the cytotoxic effects of nanosilver was systematically evaluated. RESULTS: Our results show that nanosilver toxicity was strongly affected by the composition of the culture media...
January 6, 2017: Journal of Nanobiotechnology
https://www.readbyqxmd.com/read/28056992/antioxidant-capacities-of-the-selenium-nanoparticles-stabilized-by-chitosan
#5
Xiaona Zhai, Chunyue Zhang, Guanghua Zhao, Serge Stoll, Fazheng Ren, Xiaojing Leng
BACKGROUNDS: Selenium (Se) as one of the essential trace elements for human plays an important role in the oxidation reduction system. But the high toxicity of Se limits its application. In this case, the element Se with zero oxidation state (Se(0)) has captured our attention because of its low toxicity and excellent bioavailability. However, Se(0) is very unstable and easily changes into the inactive form. By now many efforts have been done to protect its stability. And this work was conducted to explore the antioxidant capacities of the stable Se(0) nanoparticles (SeNPs) stabilized using chitosan (CS) with different molecular weights (Mws) (CS-SeNPs)...
January 5, 2017: Journal of Nanobiotechnology
https://www.readbyqxmd.com/read/28052769/elasto-inertial-microfluidics-for-bacteria-separation-from-whole-blood-for-sepsis-diagnostics
#6
Muhammad Asim Faridi, Harisha Ramachandraiah, Indradumna Banerjee, Sahar Ardabili, Sergey Zelenin, Aman Russom
BACKGROUND: Bloodstream infections (BSI) remain a major challenge with high mortality rate, with an incidence that is increasing worldwide. Early treatment with appropriate therapy can reduce BSI-related morbidity and mortality. However, despite recent progress in molecular based assays, complex sample preparation steps have become critical roadblock for a greater expansion of molecular assays. Here, we report a size based, label-free, bacteria separation from whole blood using elasto-inertial microfluidics...
January 4, 2017: Journal of Nanobiotechnology
https://www.readbyqxmd.com/read/28049488/intracellular-trafficking-and-cellular-uptake-mechanism-of-phbv-nanoparticles-for-targeted-delivery-in-epithelial-cell-lines
#7
Juan P Peñaloza, Valeria Márquez-Miranda, Mauricio Cabaña-Brunod, Rodrigo Reyes-Ramírez, Felipe M Llancalahuen, Cristian Vilos, Fernanda Maldonado-Biermann, Luis A Velásquez, Juan A Fuentes, Fernando D González-Nilo, Maité Rodríguez-Díaz, Carolina Otero
BACKGROUND: Nanotechnology is a science that involves imaging, measurement, modeling and a manipulation of matter at the nanometric scale. One application of this technology is drug delivery systems based on nanoparticles obtained from natural or synthetic sources. An example of these systems is synthetized from poly(3-hydroxybutyrate-co-3-hydroxyvalerate), which is a biodegradable, biocompatible and a low production cost polymer. The aim of this work was to investigate the uptake mechanism of PHBV nanoparticles in two different epithelial cell lines (HeLa and SKOV-3)...
January 3, 2017: Journal of Nanobiotechnology
https://www.readbyqxmd.com/read/28049483/pterodon-emarginatus-oleoresin-based-nanoemulsion-as-a-promising-tool-for-culex-quinquefasciatus-diptera-culicidae-control
#8
Anna E M F M Oliveira, Jonatas L Duarte, Rodrigo A S Cruz, Raimundo N P Souto, Ricardo M A Ferreira, Taires Peniche, Edemilson C da Conceição, Leandra A R de Oliveira, Silvia M M Faustino, Alexandro C Florentino, José C T Carvalho, Caio P Fernandes
BACKGROUND: Preparation of nanoformulations using natural products as bioactive substances is considered very promising for innovative larvicidal agents. On this context, oil in water nanoemulsions develop a main role, since they satisfactorily disperse poor-water soluble substances, such as herbal oils, in aqueous media. Pterodon emarginatus, popularly known as sucupira, has a promising bioactive oleoresin. However, to our knowledge, no previous studies were carried out to evaluate its potential against Culex quinquefasciatus, the main vector of the tropical neglected disease called lymphatic filariasis or elephantiasis...
January 3, 2017: Journal of Nanobiotechnology
https://www.readbyqxmd.com/read/27993139/biodistribution-of-biodegradable-polymeric-nano-carriers-loaded-with-busulphan-and-designed-for-multimodal-imaging
#9
Heba Asem, Ying Zhao, Fei Ye, Åsa Barrefelt, Manuchehr Abedi-Valugerdi, Ramy El-Sayed, Ibrahim El-Serafi, Khalid M Abu-Salah, Jörg Hamm, Mamoun Muhammed, Moustapha Hassan
BACKGROUND: Multifunctional nanocarriers for controlled drug delivery, imaging of disease development and follow-up of treatment efficacy are promising novel tools for disease diagnosis and treatment. In the current investigation, we present a multifunctional theranostic nanocarrier system for anticancer drug delivery and molecular imaging. Superparamagnetic iron oxide nanoparticles (SPIONs) as an MRI contrast agent and busulphan as a model for lipophilic antineoplastic drugs were encapsulated into poly (ethylene glycol)-co-poly (caprolactone) (PEG-PCL) micelles via the emulsion-evaporation method, and PEG-PCL was labelled with VivoTag 680XL fluorochrome for in vivo fluorescence imaging...
December 19, 2016: Journal of Nanobiotechnology
https://www.readbyqxmd.com/read/27993133/synthesis-and-functionalization-of-protease-activated-nanoparticles-with-tissue-plasminogen-activator-peptides-as-targeting-moiety-and-diagnostic-tool-for-pancreatic-cancer
#10
Sophie Dobiasch, Szilard Szanyi, Aleko Kjaev, Jens Werner, Albert Strauss, Christian Weis, Lars Grenacher, Katya Kapilov-Buchman, Liron-Limor Israel, Jean-Paul Lellouche, Erica Locatelli, Mauro Comes Franchini, Jennifer Vandooren, Ghislain Opdenakker, Klaus Felix
BACKGROUND: Functionalized nanoparticles (NPs) are one promising tool for detecting specific molecular targets and combine molecular biology and nanotechnology aiming at modern imaging. We aimed at ligand-directed delivery with a suitable target-biomarker to detect early pancreatic ductal adenocarcinoma (PDAC). Promising targets are galectins (Gal), due to their strong expression in and on PDAC-cells and occurrence at early stages in cancer precursor lesions, but not in adjacent normal tissues...
December 19, 2016: Journal of Nanobiotechnology
https://www.readbyqxmd.com/read/27919267/targeted-drug-delivery-of-near-ir-fluorescent-doxorubicin-conjugated-poly-ethylene-glycol-bisphosphonate-nanoparticles-for-diagnosis-and-therapy-of-primary-and-metastatic-bone-cancer-in-a-mouse-model
#11
S Rudnick-Glick, E Corem-Salkmon, I Grinberg, S Margel
BACKGROUND: Most primary and metastatic bone tumors demonstrate increased osteoclast activity and bone resorption. Current treatment is based on a combination of surgery, radiotherapy and chemotherapy. Severe side effects are associated with chemotherapy due to use of high dosage and nonspecific uptake. Bisphosphonates have a strong affinity to Ca(2+) ions and are widely used in the treatment of bone disorders. RESULTS: We have engineered a unique biodegradable bisphosphonate nanoparticle (NPs) bearing two functional surface groups: (1) primary amine groups for covalent attachment of a dye/drug (e...
December 5, 2016: Journal of Nanobiotechnology
https://www.readbyqxmd.com/read/27905946/chemically-and-thermally-stable-silica-nanowires-with-a-%C3%AE-sheet-peptide-core-for-bionanotechnology
#12
Zahraa S Al-Garawi, George E Kostakis, Louise C Serpell
BACKGROUND: A series of amyloidogenic peptides based on the sequence KFFEAAAKKFFE template the silica precursor, tetraethyl orthosilicate to form silica-nanowires containing a cross-β peptide core. RESULTS: Investigation of the stability of these fibres reveals that the silica layers protect the silica-nanowires allowing them to maintain their shape and physical and chemical properties after incubation with organic solvents such as 2-propanol, ethanol, and acetonitrile, as well as in a strong acidic solution at pH 1...
December 1, 2016: Journal of Nanobiotechnology
https://www.readbyqxmd.com/read/27903280/a-critical-review-of-the-current-knowledge-regarding-the-biological-impact-of-nanocellulose
#13
REVIEW
C Endes, S Camarero-Espinosa, S Mueller, E J Foster, A Petri-Fink, B Rothen-Rutishauser, C Weder, M J D Clift
Several forms of nanocellulose, notably cellulose nanocrystals and nanofibrillated cellulose, exhibit attractive property matrices and are potentially useful for a large number of industrial applications. These include the paper and cardboard industry, use as reinforcing filler in polymer composites, basis for low-density foams, additive in adhesives and paints, as well as a wide variety of food, hygiene, cosmetic, and medical products. Although the commercial exploitation of nanocellulose has already commenced, little is known as to the potential biological impact of nanocellulose, particularly in its raw form...
December 1, 2016: Journal of Nanobiotechnology
https://www.readbyqxmd.com/read/27894312/release-of-copper-amended-particles-from-micronized-copper-pressure-treated-wood-during-mechanical-abrasion
#14
Chiara Civardi, Lukas Schlagenhauf, Jean-Pierre Kaiser, Cordula Hirsch, Claudio Mucchino, Adrian Wichser, Peter Wick, Francis W M R Schwarze
BACKGROUND: We investigated the particles released due to abrasion of wood surfaces pressure-treated with micronized copper azole (MCA) wood preservative and we gathered preliminary data on its in vitro cytotoxicity for lung cells. The data were compared with particles released after abrasion of untreated, water (0% MCA)-pressure-treated, chromated copper (CC)-pressure-treated wood, and varnished wood. Size, morphology, and composition of the released particles were analyzed. RESULTS: Our results indicate that the abrasion of MCA-pressure-treated wood does not cause an additional release of nanoparticles from the unreacted copper (Cu) carbonate nanoparticles from of the MCA formulation...
November 28, 2016: Journal of Nanobiotechnology
https://www.readbyqxmd.com/read/27887623/generation-of-protective-immunity-against-orientia-tsutsugamushi-infection-by-immunization-with-a-zinc-oxide-nanoparticle-combined-with-scaa-antigen
#15
Na-Young Ha, Hyun Mu Shin, Prashant Sharma, Hyun Ah Cho, Chan-Ki Min, Hong-Il Kim, Nguyen Thi Hai Yen, Jae-Seung Kang, Ik-Sang Kim, Myung-Sik Choi, Young Keun Kim, Nam-Hyuk Cho
BACKGROUND: Zinc oxide nanoparticle (ZNP) has been applied in various biomedical fields. Here, we investigated the usage of ZNP as an antigen carrier for vaccine development by combining a high affinity peptide to ZNP. RESULTS: A novel zinc oxide-binding peptide (ZBP), FPYPGGDA, with high affinity to ZNP (K a  = 2.26 × 10(6) M(-1)) was isolated from a random peptide library and fused with a bacterial antigen, ScaA of Orientia tsutsugamushi, the causative agent of scrub typhus...
November 26, 2016: Journal of Nanobiotechnology
https://www.readbyqxmd.com/read/27884158/rapid-visualization-of-latent-fingermarks-using-gold-seed-mediated-enhancement
#16
Chia-Hao Su, Chun-Chieh Yu, Fong-Yu Cheng
BACKGROUND: Fingermarks are one of the most important and useful forms of physical evidence in forensic investigations. However, latent fingermarks are not directly visible, but can be visualized due to the presence of other residues (such as inorganic salts, proteins, polypeptides, enzymes and human metabolites) which can be detected or recognized through various strategies. Convenient and rapid techniques are still needed to provide obvious contrast between the background and the fingermark ridges and to then visualize latent fingermark with a high degree of selectivity and sensitivity...
November 25, 2016: Journal of Nanobiotechnology
https://www.readbyqxmd.com/read/27809857/high-efficiency-penetration-of-antibody-immobilized-nanoneedle-thorough-plasma-membrane-for-in-situ-detection-of-cytoskeletal-proteins-in-living-cells
#17
R Kawamura, K Shimizu, Y Matsumoto, A Yamagishi, Y R Silberberg, M Iijima, S Kuroda, K Fukazawa, K Ishihara, C Nakamura
BACKGROUND: The field of structural dynamics of cytoskeletons in living cells is gathering wide interest, since better understanding of cytoskeleton intracellular organization will provide us with not only insights into basic cell biology but may also enable development of new strategies in regenerative medicine and cancer therapy, fields in which cytoskeleton-dependent dynamics play a pivotal role. The nanoneedle technology is a powerful tool allowing for intracellular investigations, as it can be directly inserted into live cells by penetrating through the plasma membrane causing minimal damage to cells, under the precise manipulation using atomic force microscope...
November 3, 2016: Journal of Nanobiotechnology
https://www.readbyqxmd.com/read/27776555/pure-and-multi-metal-oxide-nanoparticles-synthesis-antibacterial-and-cytotoxic-properties
#18
REVIEW
Slavica Stankic, Sneha Suman, Francia Haque, Jasmina Vidic
Th antibacterial activity of metal oxide nanoparticles has received marked global attention as they can be specifically synthesized to exhibit significant toxicity to bacteria. The importance of their application as antibacterial agents is evident keeping in mind the limited range and effectiveness of antibiotics, on one hand, and the plethora of metal oxides, on the other, along with the propensity of nanoparticles to induce resistance being much lower than that of antibiotics. Effective inhibition against a wide range of bacteria is well known for several nano oxides consisting of one metal (Fe3O4, TiO2, CuO, ZnO), whereas, research in the field of multi-metal oxides still demands extensive exploration...
October 24, 2016: Journal of Nanobiotechnology
https://www.readbyqxmd.com/read/27769275/calcium-silicate-mesoporous-nanoparticles-loaded-with-chlorhexidine-for-both-anti-enterococcus-faecalis-and-mineralization-properties
#19
Wei Fan, Yanyun Li, Qing Sun, Tengjiao Ma, Bing Fan
BACKGROUND: In infected periapical tissues, Enterococcus faecalis is one of the most common dominant bacteria. Chlorhexidine has been proved to show strong antibacterial ability against E. faecalis but is ineffective in promoting mineralization for tissues around root apex. Mesoporous calcium-silicate nanoparticles are newly synthesized biomaterials with excellent ability to promote mineralization and carry-release bioactive molecules in a controlled manner. In this study, mesoporous calcium-silicate nanoparticles were functionalized with chlorhexidine and their releasing profile, antibacterial ability, effect on cell proliferation and in vitro mineralization property were evaluated...
October 21, 2016: Journal of Nanobiotechnology
https://www.readbyqxmd.com/read/27716314/lipid-nanoemulsions-and-liposomes-improve-photodynamic-treatment-efficacy-and-tolerance-in-cal-33-tumor-bearing-nude-mice
#20
Doris Hinger, Susanna Gräfe, Fabrice Navarro, Bernhard Spingler, Devaraj Pandiarajan, Heinrich Walt, Anne-Claude Couffin, Caroline Maake
BACKGROUND: Photodynamic therapy (PDT) as promising alternative to conventional cancer treatments works by irradiation of a photosensitizer (PS) with light, which creates reactive oxygen species and singlet oxygen ((1)O2), that damage the tumor. However, a routine use is hindered by the PS's poor water solubility and extended cutaneous photosensitivity of patients after treatment. In our study we sought to overcome these limitations by encapsulation of the PS m-tetrahydroxyphenylchlorin (mTHPC) into a biocompatible nanoemulsion (Lipidots)...
October 3, 2016: Journal of Nanobiotechnology
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