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Clinical and Molecular Allergy: CMA

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https://www.readbyqxmd.com/read/30002605/focus-on-the-agents-most-frequently-responsible-for-perioperative-anaphylaxis
#1
REVIEW
E Di Leo, P Delle Donne, G F Calogiuri, L Macchia, E Nettis
Adverse reactions (ARs) to drugs administered during general anesthesia may be very severe and life-threatening, with a mortality rate ranging from 3 to 9%. The adverse reactions to drugs may be IgE and non-IgE-mediated. Neuromuscular blocking agents (NMBA) represent the first cause of perioperative reactions during general anesthesia followed by latex, antibiotics, hypnotic agents, opioids, colloids, dyes and antiseptics (chlorhexidine). All these substances (i.e. NMBA, anesthetics, antibiotics, latex devices) may cause severe systemic non-IgE-mediated reactions or fatal anaphylactic events even in the absence of any evident risk factor in the patient's anamnesis...
2018: Clinical and Molecular Allergy: CMA
https://www.readbyqxmd.com/read/29946225/house-dust-mite-related-respiratory-allergies-and-probiotics-a-narrative-review
#2
REVIEW
Filippo Fassio, Fabio Guagnini
The socio-economic burden of allergic respiratory conditions on continental Europe is even higher than that of mainstream diseases, such as diabetes and cardiovascular disease, as allergic rhinitis alone accounts for billions of Euros in healthcare expenses across Europe. House dust mites (HDM) are one of the most common triggers behind allergic rhinitis and asthma. The role of probiotics in the treatment and prevention of some allergic conditions, such as atopic dermatitis, is already well recognized, whereas evidence about their efficacy in patients with respiratory allergies-while increasing-is still limited...
2018: Clinical and Molecular Allergy: CMA
https://www.readbyqxmd.com/read/29930483/sublingual-grass-allergen-specific-immunotherapy-a-retrospective-study-of-clinical-outcome-and-discontinuation
#3
Christer Janson, Fredrik Sundbom, Peter Arvidsson, Mary Kämpe
Background: Sublingual immunotherapy (SLIT) is effective, tolerable, and convenient for many allergic patients. Still, real-world evidence is scarce and the aim of this study is to assess the patient reported outcome of treatment with SLIT against grass pollen allergy in a consecutive patient population. Methods: Patients (n = 329) who were confirmed to be allergic to timothy grass and had been prescribed SLIT were consecutively enrolled in the study and completed a questionnaire online or in hard copy...
2018: Clinical and Molecular Allergy: CMA
https://www.readbyqxmd.com/read/29796009/regulation-of-ige-activity-in-inhalational-tolerance-via-formation-of-igg-anti-ige-ige-immune-complexes
#4
Sonali J Bracken, Alexander J Adami, Ektor Rafti, Craig M Schramm, Adam P Matson
Background: Allergic asthma is an inflammatory disorder of the airways that results from inappropriate production of IgE against harmless, environmental antigens. Sequestration of free IgE using humanized IgG anti-IgE is an effective therapy for asthma and other atopic disorders. However, the status of free IgE in subjects who have naturally developed immune tolerance to inhaled antigens has not been well studied. Methods: C57BL/6 mice were sensitized and challenged with ovalbumin (OVA) for 7 days to induce allergic airway disease (AAD) or 6 weeks to induce a state of local inhalational tolerance (LIT)...
2018: Clinical and Molecular Allergy: CMA
https://www.readbyqxmd.com/read/29796008/low-incidence-of-pneumonia-in-copd-patients-treated-with-inhaled-corticosteroids-undergoing-pulmonary-rehabilitation
#5
Erminia Ridolo, Cristoforo Incorvaia, Irene Martignago, Laura Pessina, Fulvio Lauretani, Luciano Loperfido, Gian Galeazzo Riario-Sforza, Annalisa Broglia, Bruna L Gritti, Lorenzo Panella
Background: Based on meta-analyses results, it is currently acknowledged that there is an increased risk of pneumonia in patients with chronic obstructive pulmonary disease (COPD) undergoing inhaled corticosteroids (ICS) treatment. However, this is not found to be true in those with asthma. No data on this risk are available for COPD patients involved in pulmonary rehabilitation program (PR). Methods: For 1 year, we prospectively studied 2 cohorts of COPD patients-undergoing PR and not undergoing PR...
2018: Clinical and Molecular Allergy: CMA
https://www.readbyqxmd.com/read/29743819/involvement-of-mir-126-in-autoimmune-disorders
#6
REVIEW
Marco Casciaro, Eleonora Di Salvo, Teresa Brizzi, Carmelo Rodolico, Sebastiano Gangemi
Background: Micro-RNA represent a great family of small non-condign ribonucleic acid molecules; in particular microRNA-126 is an important member of this family and is expressed in many human cells such as cardiomyocytes, endothelial and lung cells. Some studies have shown the implication of miR-126 in cancer, but recently significant progresses have also been made in determining the role of miR-126 regulating immune-related diseases; probably, in a near future, they could potentially serve as diagnostic biomarkers or therapeutic targets...
2018: Clinical and Molecular Allergy: CMA
https://www.readbyqxmd.com/read/29686538/hymenoptera-sting-reactions-in-southern-italy-forestry-workers-our-experience-compared-to-reported-data
#7
Luisa Ricciardi, Francesco Papia, Giuseppe Cataldo, Mario Giorgianni, Giovanna Spatari, Sebastiano Gangemi
Background: Hymenoptera sting reactions are among life-threatening causes of allergy. Several epidemiology studies have assessed the risk of these kind of reactions, among the general population, around 3% of adults. This incidence increases among highly at risk populations such as outdoor workers. Hymenoptera stings among forestry workers (FW) are occupational triggers but it has not yet been well defined which is the real incidence of anaphylaxis in these workers, not even in Italy...
2018: Clinical and Molecular Allergy: CMA
https://www.readbyqxmd.com/read/29651227/a-case-of-atopic-dermatitis-caused-by-ascaris-lumbricoides-infection
#8
Rosanna Qualizza, Laura M Losappio, Fabiana Furci
Background: Parasite infections stimulate total and specific IgE production that, in the case of Toxocara canis infection, corresponds to chronic allergic symptoms. There may also be other infections which have similar symptoms, such as Ascaris lumbricoides infection. Ascaris lumbricoides is a large nematode that causes abdominal pain, nausea, vomiting, bloating, anorexia and intermittent diarrhoea. Patients with ascaridiasis and high IgE levels may also have allergy-like symptoms such as asthma, urticaria and atopic dermatitis...
2018: Clinical and Molecular Allergy: CMA
https://www.readbyqxmd.com/read/29618952/role-of-genetic-variations-of-chitinase-3-like-1-in-bronchial-asthmatic-patients
#9
Kazuyuki Abe, Yutaka Nakamura, Kohei Yamauchi, Makoto Maemondo
Background: Single nucleotide polymorphisms (SNPs) in chitinase 3 - like 1 ( CHI3L1 ) are associated with bronchial severity and pulmonary function. CHI3L1 proteins are involved in both innate and adaptive immune responses; however, to date, the correlation of these SNPs and their age of onset of bronchial asthma has not been demonstrated. Methods: To address the role of these genetic variations, 390 patients with well-controlled bronchial asthma and living in Japan were recruited, genotyped, and had a pulmonary function test performed on them in this study...
2018: Clinical and Molecular Allergy: CMA
https://www.readbyqxmd.com/read/29618951/importance-of-hypersensitivity-in-adverse-reactions-to-drugs-in-the-elderly
#10
Maria Teresa Ventura, Elisa Boni, Rosa Cecere, Rosalba Buquicchio, Gian Franco Calogiuri, Irene Martignago, Cristoforo Incorvaia, Erminia Ridolo
Background: The use of drugs in the elderly is very extensive because of the frequent occurrence of chronic diseases. Adverse drug reactions (ADRs) commonly occur in geriatric patients receiving multiple therapeutic regimens. In the literature, little attention has been given to ADRs in the elderly, and particularly to allergic reactions. Objective: The aim of the present study is to provide data on possible inappropriate prescriptions in the elderly in relation to allergic reactions and to identify a list of drugs which are likely inducers of allergic reactions...
2018: Clinical and Molecular Allergy: CMA
https://www.readbyqxmd.com/read/29540998/bench-to-bedside-review-of-myositis-autoantibodies
#11
REVIEW
Boaz Palterer, Gianfranco Vitiello, Alessia Carraresi, Maria Grazia Giudizi, Daniele Cammelli, Paola Parronchi
Idiopathic inflammatory myopathies represent a heterogeneous group of autoimmune diseases with systemic involvement. Even though numerous specific autoantibodies have been recognized, they have not been included, with the only exception of anti-Jo-1, into the 2017 Classification Criteria, thus perpetuating a clinical-serologic gap. The lack of homogeneous grouping based on the antibody profile deeply impacts the diagnostic approach, therapeutic choices and prognostic stratification of these patients. This review is intended to highlight the comprehensive scenario regarding myositis-related autoantibodies, from the molecular characterization and biological significance to target antigens, from the detection tools, with a special focus on immunofluorescence patterns on HEp-2 cells, to their relative prevalence and ethnic diversity, from the clinical presentation to prognosis...
2018: Clinical and Molecular Allergy: CMA
https://www.readbyqxmd.com/read/29527129/a-critical-appraisal-on-ait-in-childhood-asthma
#12
REVIEW
Matteo Ferrando, Francesca Racca, Lorena Nascimento Girardi Madeira, Enrico Heffler, Giovanni Passalacqua, Francesca Puggioni, Niccolò Stomeo, Giorgio Walter Canonica
Abstract: Allergen immunotherapy (AIT) is the only disease-modifying treatment approved for allergic rhinitis and allergic asthma and represents a suitable therapeutic option, especially in childhood, to modify the progression of respiratory allergic diseases. Starting from the previous "generic class effect" evaluation, as testified by the numerous meta analyses, AIT is now considered a product-specific pathogenic-oriented treatment. Background: AIT was empirically proposed more than one century ago in the subcutaneous form (SCIT), but the IgE-mediated mechanism of allergy was elucidated only after 50 years of clinical use of the treatment...
2018: Clinical and Molecular Allergy: CMA
https://www.readbyqxmd.com/read/29434524/the-control-of-allergic-rhinitis-in-real-life-a-multicenter-cross-sectional-italian-study
#13
Federica Gani, Carlo Lombardi, Laura Barrocu, Massimo Landi, Erminia Ridolo, Massimo Bugiani, Giovanni Rolla, Gianenrico Senna, Giovanni Passalacqua
Background: Allergic Rhinitis (AR) is a high-prevalence disease. In Europe about 25% of the general population is affected, and in Italy the prevalence is estimated to be 19.8%. The Allergic Rhinitis and its Impact on Asthma (ARIA) international document underlined that the prevalence of severe or refractory or overlapping rhinitis is increasing and represents a non-negligible socio-economic burden. In general, despite the social healthcare costs, allergic rhinitis remains underestimated, not sufficiently controlled and often undertreated...
2018: Clinical and Molecular Allergy: CMA
https://www.readbyqxmd.com/read/29434523/allergic-sensitization-to-common-pets-cats-dogs-according-to-different-possible-modalities-of-exposure-an-italian-multicenter-study
#14
G Liccardi, L Calzetta, G Baldi, A Berra, L Billeri, M Caminati, P Capano, E Carpentieri, A Ciccarelli, M A Crivellaro, M Cutajar, M D'Amato, I Folletti, F Gani, D Gargano, D Giannattasio, M Giovannini, C Lombardi, M Lo Schiavo, F Madonna, M Maniscalco, A Meriggi, C Micucci, M Milanese, C Montera, G Paolocci, R Parente, A Pedicini, R Pio, F Puggioni, M Russo, A Salzillo, P Scavalli, N Scichilone, B Sposato, A Stanziola, G Steinhilber, A Vatrella, P Rogliani, G Passalacqua
Background: The query "are there animals at home?" is usually administered for collecting information on anamnesis. This modality to consider exposure to pet allergens constitutes a potential bias in epidemiological studies and in clinical practice. The aim of our study was to evaluate/quantify different modalities of exposure to cat/dog in inducing allergic sensitization. Methods: Thirty Italian Allergy units participated in this study. Each centre was required to collect the data of at least 20 consecutive outpatients sensitized to cat/dog allergens...
2018: Clinical and Molecular Allergy: CMA
https://www.readbyqxmd.com/read/29375272/a-13-year-real-life-study-on-efficacy-safety-and-biological-effects-of-vespula-venom-immunotherapy
#15
Marcello Albanesi, Andrea Nico, Alessandro Sinisi, Lucia Giliberti, Maria Pia Rossi, Margherita Rossini, Georgios Kourtis, Anna Simona Rucco, Filomena Loconte, Loredana Muolo, Marco Zurlo, Danilo Di Bona, Maria Filomena Caiaffa, Luigi Macchia
Background: Hymenoptera venom immunotherapy (VIT) is a clinically effective treatment. However, little is known about its long-term clinical efficacy and biological effects. Several mechanisms have been proposed to account for VIT efficacy, including reduction of specific IgE and induction of allergen-specific IgG4 , but the overall picture remains elusive. We investigated Vespula VIT clinical efficacy up to 8 years after discontinuation and the kinetics of Vespula -specific IgE and IgG4 ...
2018: Clinical and Molecular Allergy: CMA
https://www.readbyqxmd.com/read/29344005/biological-clocks-their-relevance-to-immune-allergic-diseases
#16
REVIEW
Roberto Paganelli, Claudia Petrarca, Mario Di Gioacchino
The 2017 Nobel Prize for Physiology or Medicine, awarded for the discoveries made in the past 15 years on the genetic and molecular mechanisms regulating many physiological functions, has renewed the attention to the importance of circadian rhythms. These originate from a central pacemaker in the suprachiasmatic nucleus in the brain, photoentrained via direct connection with melanopsin containing, intrinsically light-sensitive retinal ganglion cells, and it projects to periphery, thus creating an inner circadian rhythm...
2018: Clinical and Molecular Allergy: CMA
https://www.readbyqxmd.com/read/29785175/how-to-fit-allergen-immunotherapy-in-the-elderly
#17
REVIEW
Erminia Ridolo, Anti Rogkakou, Maria Teresa Ventura, Irene Martignago, Cristoforo Incorvaia, Gabriele Di Lorenzo, Giovanni Passalacqua
Asthma, allergic rhinitis (AR) and atopic dermatitis are very common in young people, but in the latest decades it was increasingly recognized that also individuals of higher ages, including the population over 65 years, are concerned. Actually, it is now acknowledged the aging does not considerably alter the immune response to allergens. Allergen immunotherapy (AIT) is the only treatment that works on the causes of allergy, but elderly people are commonly excluded from AIT, except the cases of insect sting allergy...
2017: Clinical and Molecular Allergy: CMA
https://www.readbyqxmd.com/read/29299028/amelioration-of-patients-with-chronic-spontaneous-urticaria-in-treatment-with-vitamin-d-supplement
#18
Nazila Ariaee, Shima Zarei, Mojgan Mohamadi, Farahzad Jabbari
Background: Spontaneous urticaria is a common allergic skin condition affecting 0.5-1% of individuals and may burden on health care expenditure or may be associated with remarkable morbidity. Aim: In this study, we measured the effect of vitamin D supplementation in patients with a diagnosis of CSU. Furthermore, quality of life and cytokine changes were evaluated. Methods: The clinical trial was conducted on 20 patients with idiopathic chronic urticaria...
2017: Clinical and Molecular Allergy: CMA
https://www.readbyqxmd.com/read/29259496/immunosenescence-in-aging-between-immune-cells-depletion-and-cytokines-up-regulation
#19
REVIEW
Maria Teresa Ventura, Marco Casciaro, Sebastiano Gangemi, Rosalba Buquicchio
Background: The immunosenescence is a relatively recent chapter, correlated with the linear extension of the average life began in the nineteenth century and still in progress. The most important feature of immunosenescence is the accumulation in the "immunological space" of memory and effector cells as a result of the stimulation caused by repeated clinical and subclinical infections and by continuous exposure to antigens (inhalant allergens, food, etc.). This state of chronic inflammation that characterizes senescence has a significant impact on survival and fragility...
2017: Clinical and Molecular Allergy: CMA
https://www.readbyqxmd.com/read/29213218/tiotropium-in-asthma-back-to-the-future-of-anticholinergic-treatment
#20
REVIEW
Matteo Bonini, Nicola Scichilone
Asthma is among the most common chronic diseases worldwide; however, despite progresses in the understanding of the patho-physiological mechanisms and advances in the development of new therapeutic options and strategies, the disease remains uncontrolled in a not trivial proportion of subjects. Thus, the need of new molecules to treat the underlying biological and functional abnormalities and to control symptoms is strongly advocated by clinicians. In this scenario, the most recent GINA guidelines have included the use of tiotropium bromide in the most severe and uncontrolled forms of the disease, in addition to treatment with inhaled corticosteroid plus long acting beta adrenergic agents...
2017: Clinical and Molecular Allergy: CMA
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