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Clinical and Molecular Allergy: CMA

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https://www.readbyqxmd.com/read/27826220/chitinase-3-like-1-is-produced-by-human-th17-cells-and-correlates-with-the-level-of-inflammation-in-juvenile-idiopathic-arthritis-patients
#1
Manuela Capone, Laura Maggi, Veronica Santarlasci, Maria Caterina Rossi, Alessio Mazzoni, Gianni Montaini, Rolando Cimaz, Matteo Ramazzotti, Marie Pierre Piccinni, Giusi Barra, Raffaele De Palma, Francesco Liotta, Enrico Maggi, Sergio Romagnani, Francesco Annunziato, Lorenzo Cosmi
BACKGROUND: CHI3L1 is a chitinase-like protein without enzymatic activity, produced by activated macrophages, chondrocytes, neutrophils. Recent studies on arthritis, asthma, and inflammatory bowel diseases suggest that chitinases are important in inflammatory processes and tissue remodeling, but their production by human T cells, has never been reported. METHODS: A microarray analysis of gene expression profile was performed on Th17 and classic Th1 cell clones and CHI3L1 was found among the up-regulated genes on Th17 cells...
2016: Clinical and Molecular Allergy: CMA
https://www.readbyqxmd.com/read/27822141/hiv-1-nef-promotes-migration-and-chemokine-synthesis-of-human-basophils-and-mast-cells-through-the-interaction-with-cxcr4
#2
Francesca Wanda Rossi, Nella Prevete, Felice Rivellese, Antonio Lobasso, Filomena Napolitano, Francescopaolo Granata, Carmine Selleri, Amato de Paulis
BACKGROUND: The Nef protein can be detected in plasma of HIV-1-infected patients and plays a role in the pathogenesis of HIV-1. Nef produced during the early stages of infection is fundamental in creating the ideal environment for viral replication, e.g. by reducing the ability of infected cells to induce an immune response. AIM: Based on previous experience showing that both Tat and gp41 of HIV-1 are potent chemotactic factors for basophils and mast cells, and gp120 is a powerful stimulus for the release of histamine and cytokines (IL-4 and IL-13) from basophils, in this study we aimed to verify if the HIV Nef protein can exert some effects on basophils and mast cells purified from healthy volunteers through the interaction with the CXCL12 receptor, CXCR4...
2016: Clinical and Molecular Allergy: CMA
https://www.readbyqxmd.com/read/27799850/dose-dependence-of-protection-from-systemic-reactions-to-venom-immunotherapy-by-omalizumab
#3
Elisa Boni, Cristoforo Incorvaia, Marina Mauro
BACKGROUND: Systemic reactions (SR) to venom immunotherapy (VIT) are rare but may occur, with a rate significantly higher for honeybee than for vespid VIT. In patients with repeated SRs to VIT it is difficult to reach the maintenance dose of venom and pre-treatment with omalizumab is indicated, as shown by some studies reporting its preventative capacity, when antihistamines and corticosteroids are ineffective. CASE PRESENTATION: We present the case of a 47 years old woman allergic to bee venom who experienced two severe SRs after bee stings and several SRs to VIT with bee venom...
2016: Clinical and Molecular Allergy: CMA
https://www.readbyqxmd.com/read/27752240/mastocytosis-and-systemic-sclerosis-a-clinical-association
#4
Gianluca Bagnato, William Neal Roberts, Davide Sciortino, Donatella Sangari, Santa Cirmi, Roneka L Ravenell, Michele Navarra, Gianfilippo Bagnato, Sebastiano Gangemi
BACKGROUND: Systemic sclerosis (SSc) is a complex autoimmune disease characterized by vascular alterations and autoimmune activation leading to widespread organ fibrosis. At the early stage of disease when organ involvement and extent of disease are emerging, mast cells may have some role, as implied by both symptoms and histologic evidence. CASE PRESENTATION: A female patient diagnosed with cutaneous mastocytosis experienced the onset of systemic sclerosis after 15 years followed by the switch of mastocytosis to the systemic phenotype...
2016: Clinical and Molecular Allergy: CMA
https://www.readbyqxmd.com/read/27708552/burden-of-allergic-respiratory-disease-a-systematic-review
#5
A Linneberg, K Dam Petersen, J Hahn-Pedersen, E Hammerby, N Serup-Hansen, N Boxall
This meta-analysis compared the health-related quality of life (HRQL) of patients with allergic rhinitis (AR) and/or allergic asthma (AA) caused by perennial house dust mite (HDM) versus AR and/or AA caused by seasonal pollen allergy. Following a systematic search, the identified studies used the disease-specific rhinitis quality of life questionnaire or generic instruments (SF-36 and SF-12). Summary estimates obtained by meta-analysis showed that HRQL in patients with perennial HDM allergy was significantly worse than that of patients with seasonal pollen allergy, when measured by both disease-specific and generic HRQL instruments, and was reflected by an impact on both physical and mental health...
2016: Clinical and Molecular Allergy: CMA
https://www.readbyqxmd.com/read/27651750/how-pregnancy-can-affect-autoimmune-diseases-progression
#6
REVIEW
Marie-Pierre Piccinni, Letizia Lombardelli, Federica Logiodice, Ornela Kullolli, Paola Parronchi, Sergio Romagnani
Autoimmune disorders are characterized by tissue damage, caused by self-reactivity of different effectors mechanisms of the immune system, namely antibodies and T cells. Their occurrence may be associated with genetic and/or environmental predisposition and to some extent, have implications for fertility and obstetrics. The relationship between autoimmunity and reproduction is bidirectional. This review only addresses the impact of pregnancy on autoimmune diseases and not the influence of autoimmunity on pregnancy development...
2016: Clinical and Molecular Allergy: CMA
https://www.readbyqxmd.com/read/27587983/unmet-diagnostic-needs-in-contact-oral-mucosal-allergies
#7
REVIEW
Paola Lucia Minciullo, Giovanni Paolino, Maddalena Vacca, Sebastiano Gangemi, Eustachio Nettis
The oral mucosa including the lips is constantly exposed to several noxious stimuli, irritants and allergens. However, oral contact pathologies are not frequently seen because of the relative resistance of the oral mucosa to irritant agents and allergens due to anatomical and physiological factors. The spectrum of signs and symptoms of oral contact allergies (OCA) is broad and a large number of condition can be the clinical expression of OCA such as allergic contact stomatitis, allergic contact cheilitis, geographic tongue, oral lichenoid reactions, burning mouth syndrome...
2016: Clinical and Molecular Allergy: CMA
https://www.readbyqxmd.com/read/27551239/drug-induced-exfoliative-dermatitis-state-of-the-art
#8
REVIEW
Mona-Rita Yacoub, Alvise Berti, Corrado Campochiaro, Enrico Tombetti, Giuseppe Alvise Ramirez, Andrea Nico, Elisabetta Di Leo, Paola Fantini, Maria Grazia Sabbadini, Eustachio Nettis, Giselda Colombo
Drug induced exfoliative dermatitis (ED) are a group of rare and severe drug hypersensitivity reactions (DHR) involving skin and usually occurring from days to several weeks after drug exposure. Erythema multiforme (EM), Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) are the main clinical presentations of drug induced ED. Overall, T cells are the central player of these immune-mediated drug reactions. Here we provide a systematic review on frequency, risk factors, pathogenesis, clinical features and management of patients with drug induced ED...
2016: Clinical and Molecular Allergy: CMA
https://www.readbyqxmd.com/read/27547124/pilot-study-assessing-the-clinical-diagnosis-of-allergy-in-atopic-children-using-a-microarray-assay-in-addition-to-skin-prick-testing-and-serum-specific-ige
#9
Ru-Xin Foong, Graham Roberts, Adam Tobias Fox, George du Toit
BACKGROUND: Children with atopic dermatitis (AD) are at risk of developing allergy. Alongside clinical history, testing modalities include skin prick tests (SPT), specific immunoglobulin-E (sp-IgE) and recently, microarray assays. The aim of this pilot study was to assess current tests and the ISAC sIgE-112 system in the diagnosis of food and aeroallergen allergy. METHODS: Children aged 0-11 years with moderate to severe AD were included. An initial allergy assessment including clinical history, SPT and sp-IgE was performed to determine food and aeroallergen sensitization...
2016: Clinical and Molecular Allergy: CMA
https://www.readbyqxmd.com/read/27499704/vitamin-d3-improves-the-effects-of-low-dose-der-p-2-allergoid-treatment-in-der-p-2-sensitized-balb-c-mice
#10
Claudia Petrarca, Emanuela Clemente, Valentina Amato, Alessia Gatta, Sara Cortese, Alessia Lamolinara, Cosmo Rossi, Stefania Zanotta, Gianni Mistrello, Roberto Paganelli, Mario Di Gioacchino
BACKGROUND: Airborne allergens can induce an immunological chronic disease characterized by airway hyper responsiveness and inflammation, mediated by exaggerated Th2 immune response. Allergen-specific immunotherapy (AIT) is effective for treating this condition because it is able to modify its natural course by opposing the underlying pathogenic mechanisms and determining immune suppression, immune deviation and tolerance. The rational for the present study was to investigate the possibility of improving allergoid-based IT in terms of efficacy and safety...
2016: Clinical and Molecular Allergy: CMA
https://www.readbyqxmd.com/read/27429595/thrombotic-risk-assessment-in-antiphospholipid-syndrome-the-role-of-new-antibody-specificities-and-thrombin-generation-assay
#11
REVIEW
Savino Sciascia, Simone Baldovino, Karen Schreiber, Laura Solfietti, Massimo Radin, Maria J Cuadrado, Elisa Menegatti, Doruk Erkan, Dario Roccatello
Antiphospholipid syndrome (APS) is an autoimmune condition characterized by the presence of antiphospholipid antibodies (aPL) in subjects presenting with thrombosis and/or pregnancy loss. The currently used classification criteria were updated in the international consensus held in Sidney in 2005. Vascular events seem to result of local procoagulative alterations upon triggers influence (the so called "second-hit theory"), while placental thrombosis and complement activation seem to lead to pregnancy morbidity...
2016: Clinical and Molecular Allergy: CMA
https://www.readbyqxmd.com/read/27099567/appropriateness-in-allergic-respiratory-diseases-health-care-in-italy-definitions-and-organizational-aspects
#12
Carlo Lombardi, Eleonora Savi, Maria Teresa Costantino, Enrico Heffler, Manlio Milanese, Giovanni Passalacqua, Giorgio Walter Canonica
In a historical period in which sustainability of the National Health Service is mandatory because of the international economical situation, the limited available resources at national level and the tendency of passing from a "population medicine" model towards the concept of "individualized medicine", the debate on appropriateness of medical and surgical procedures is of central importance. The choosing wisely campaign, started in United States in 2012 and then spread all over the world, tries to summarize which are the most inappropriate procedures for each medical and surgical speciality; as far as allergic respiratory diseases, the most relevant Italian societies and the American Academy defined the allergological procedures with the highest probability of inappropriateness...
2016: Clinical and Molecular Allergy: CMA
https://www.readbyqxmd.com/read/26893591/quality-of-life-in-patients-with-food-allergy
#13
REVIEW
Darío Antolín-Amérigo, Luis Manso, Marco Caminati, Belén de la Hoz Caballer, Inmaculada Cerecedo, Alfonso Muriel, Mercedes Rodríguez-Rodríguez, José Barbarroja-Escudero, María José Sánchez-González, Beatriz Huertas-Barbudo, Melchor Alvarez-Mon
Food allergy has increased in developed countries and can have a dramatic effect on quality of life, so as to provoke fatal reactions. We aimed to outline the socioeconomic impact that food allergy exerts in this kind of patients by performing a complete review of the literature and also describing the factors that may influence, to a greater extent, the quality of life of patients with food allergy and analyzing the different questionnaires available. Hitherto, strict avoidance of the culprit food(s) and use of emergency medications are the pillars to manage this condition...
2016: Clinical and Molecular Allergy: CMA
https://www.readbyqxmd.com/read/26858583/comparing-the-ability-of-molecular-diagnosis-and-cap-inhibition-in-identifying-the-really-causative-venom-in-patients-with-positive-tests-to-vespula-and-polistes-species
#14
Eleonora Savi, Silvia Peveri, Elena Makri, Valerio Pravettoni, Cristoforo Incorvaia
BACKGROUND: Cross-reactivity among Hymenoptera venoms is an important issue when prescribing venom immunotherapy (VIT). Using all venoms eliciting a positive response results in treatment excess and unjustified cost increase. The first in vitro method that helped to identify the really causative venom was RAST-inhibition, but in latest years also molecular allergy (MA) diagnostics, that detects specific sIgE to single venom allergens, was introduced. We compared the two methods in patients with double sensitization to Vespula spp...
2016: Clinical and Molecular Allergy: CMA
https://www.readbyqxmd.com/read/26811697/skin-microbiota-of-first-cousins-affected-by-psoriasis-and-atopic-dermatitis
#15
Lorenzo Drago, Roberta De Grandi, Gianfranco Altomare, Paolo Pigatto, Oliviero Rossi, Marco Toscano
BACKGROUND: Psoriasis and atopic dermatitis (AD) are chronic inflammatory skin diseases, which negatively influence the quality of life. In the last years, several evidences highlighted the pivotal role of skin bacteria in worsening the symptomatology of AD and psoriasis. In the present study we evaluated the skin microbiota composition in accurately selected subjects affected by (AD) and psoriasis. METHODS: Three first cousins were chosen for the study according to strict selection of criteria...
2016: Clinical and Molecular Allergy: CMA
https://www.readbyqxmd.com/read/26798325/interleukin-17-producing-decidual-cd4-t-cells-are-not-deleterious-for-human-pregnancy-when-they-also-produce-interleukin-4
#16
Letizia Lombardelli, Federica Logiodice, Maryse Aguerre-Girr, Ornela Kullolli, Herman Haller, Ysabel Casart, Alain Berrebi, Fatima-Ezzahra L'Faqihi-Olive, Valérie Duplan, Sergio Romagnani, Enrico Maggi, Daniel Rukavina, Philippe Le Bouteiller, Marie-Pierre Piccinni
BACKGROUND: Trophoblast expressing paternal HLA-C antigens resemble a semiallograft, and could be rejected by maternal CD4+ T lymphocytes. We examined the possible role in human pregnancy of Th17 cells, known to be involved in allograft rejection and reported for this reason to be responsible for miscarriages. We also studied Th17/Th1 and Th17/Th2 cells never investigated before. We defined for the first time the role of different Th17 subpopulations at the embryo implantation site and the role of HLA-G5, produced by the trophoblast/embryo, on Th17 cell differentiation...
2016: Clinical and Molecular Allergy: CMA
https://www.readbyqxmd.com/read/26696778/erratum-to-guidelines-for-the-use-and-interpretation-of-diagnostic-methods-in-adult-food-allergy
#17
Donatella Macchia, Giovanni Melioli, Valerio Pravettoni, Eleonora Nucera, Marta Piantanida, Marco Caminati, Corrado Campochiaro, Mona-Rita Yacoub, Domenico Schiavino, Roberto Paganelli, Mario Di Gioacchino
[This corrects the article DOI: 10.1186/s12948-015-0033-9.].
2015: Clinical and Molecular Allergy: CMA
https://www.readbyqxmd.com/read/26674806/determinants-of-venom-specific-ige-antibody-concentration-during-long-term-wasp-venom-immunotherapy
#18
Valerio Pravettoni, Marta Piantanida, Laura Primavesi, Stella Forti, Elide A Pastorello
BACKGROUND: Venom immunotherapy (VIT) is an effective treatment for subjects with systemic allergic reactions (SR) to Hymenoptera stings, however there are few studies concerning the relevance of the venom specific IgE changes to decide about VIT cessation. We assessed IgE changes during a 5-year VIT, in patients stung and protected within the first 3 years (SP 0-3) or in the last 2 years (SP 3-5), and in patients not stung (NoS), to evaluate possible correlations between IgE changes and clinical protection...
2015: Clinical and Molecular Allergy: CMA
https://www.readbyqxmd.com/read/26633941/different-co-sensitizations-could-determine-different-risk-assessment-in-peach-allergy-evaluation-of-an-anaphylactic-biomarker-in-pru-p-3-positive-patients
#19
Carina Gabriela Uasuf, Danilo Villalta, Maria Elisabetta Conte, Caterina Di Sano, Maria Barrale, Vincenzo Cantisano, Elisabetta Pace, Mark Gjomarkaj, Sebastiano Gangemi, Ignazio Brusca
BACKGROUND: In Italy, the nsLTP (Pru p 3) has been identified as the most frequent cause of food allergy and anaphylaxis. In order to estimate the risk assessment in peach allergy, we investigated the presence of correlations between the levels of sIgE to Pru p 3 with the severity of the clinical symptoms in two Pru p 3 positive populations from two different areas of Italy. METHODS: 133 consecutively Pru p 3 positive patients were recruited from South Italy, where the prevalence of PR-10 and profilin sensitization is low, and from North-East Italy, where the sensitization to pathogenesis related protein -10 (PR-10) and profilin is higher...
2015: Clinical and Molecular Allergy: CMA
https://www.readbyqxmd.com/read/26594132/choosing-wisely-in-allergology-a-slow-medicine-approach-to-the-discipline-promoted-by-the-italian-society-of-allergy-asthma-and-clinical-immunology-siaaic
#20
Enrico Heffler, Massimo Landi, Silvana Quadrino, Cristoforo Incorvaia, Stefano Pizzimenti, Sandra Vernero, Nunzio Crimi, Giovanni Rolla, Giorgio Walter Canonica
BACKGROUND: One of the main problem health care systems are facis is the mis-use and over-use of medical resources (including useless exams, surgical interventions, medical treatments, screening procedures…) which may lead to high health care related costs without increased patients' benefit and possible harm to the patients themselves. The "Choosing wisely" campaign, in Italy denominated "Doing more does not mean doing better", tries to educate doctors and citizens at a correct use of medical resources...
2015: Clinical and Molecular Allergy: CMA
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