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Hepatobiliary & Pancreatic Diseases International: HBPD INT

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https://www.readbyqxmd.com/read/29724676/a-pooled-analysis-of-treatment-and-prognosis-of-hepatic-angiosarcoma-in-adults
#1
De-Bang Li, Xiao-Ying Si, Tao Wan, Yan-Ming Zhou
BACKGROUND: Hepatic angiosarcoma is a rare malignant vascular tumor presenting unique treatment challenges. The aim of the present study was to determine the treatment and prognosis of this entity. DATA SOURCES: A systematic literature search was conducted using PubMed, Embase and Chinese Biomedical Literature database, to identify articles published from January 1980 to July 2017. Search terms were "hepatic angiosarcoma" and "liver angiosarcoma"...
April 23, 2018: Hepatobiliary & Pancreatic Diseases International: HBPD INT
https://www.readbyqxmd.com/read/29748147/17-beta-hydroxysteroid-dehydrogenase-13-inhibits-the-progression-and-recurrence-of-hepatocellular-carcinoma
#2
Jun Chen, Jian-Yong Zhuo, Fan Yang, Zhi-Kun Liu, Lin Zhou, Hai-Yang Xie, Xiao Xu, Shu-Sen Zheng
BACKGROUND: Our previous study showed that 17-beta-hydroxysteroid dehydrogenase 13 (HSD17B13) is down-regulated in hepatocellular carcinoma (HCC). But its function in HCC remains unknown. This study aimed to reveal the function of HSD17B13 and its clinical significance in HCC. METHODS: mRNA levels of HSD17B13 were analyzed in cohort 1 (30 normal, 30 HBV cirrhosis, 60 HBV-related HCC and 60 peritumoral tissue) by real-time PCR. HSD17B13 protein was evaluated in cohort 2 (15 normal, 33 HBV-cirrhosis, 12 dysplastic nodules, 34 HBV-related HCC, and 9 metastatic HCC) using immunohistochemistry...
April 22, 2018: Hepatobiliary & Pancreatic Diseases International: HBPD INT
https://www.readbyqxmd.com/read/29716791/predictors-of-30-day-readmission-following-pancreatic-surgery-a-retrospective-review
#3
Leo I Amodu, Jamil Alexis, Aron Soleiman, Meredith Akerman, Poppy Addison, Toni Iurcotta, Horacio L Rodriguez Rilo
BACKGROUND: Pancreatectomies have been identified as procedures with an increased risk of readmission. In surgical patients, readmissions within 30 days of discharge are usually procedure-related. We sought to determine predictors of 30-day readmission following pancreatic resections in a large healthcare system. METHODS: We retrospectively collected information from the records of 383 patients who underwent pancreatic resections from 2004-2013. To find the predictors of readmission in the 30 days after discharge, we performed a univariate screen of possible variables using the Fisher's exact test for categorical variables and the Mann-Whitney U test for continuous variables...
April 22, 2018: Hepatobiliary & Pancreatic Diseases International: HBPD INT
https://www.readbyqxmd.com/read/29735301/apolipoprotein-a5-gene-polymorphisms-are-associated-with-non-alcoholic-fatty-liver-disease
#4
Yue Xu, Lin-Lin Lu, Shou-Sheng Liu, Shui-Xian Du, Hui-Ling Zhu, Quan-Jiang Dong, Yong-Ning Xin
BACKGROUND: Several studies have reported that apolipoprotein A5 (APOA5) is involved in the development of non-alcoholic fatty liver disease (NAFLD). However, no research has been performed regarding the association between APOA5 polymorphisms and the risk of NAFLD. This study aimed to explore the association between APOA5 gene polymorphisms and NAFLD in a Chinese Han population. METHODS: Genotypes of the SNPs (rs10750097, rs1263173, rs17120035, rs3135507 and rs662799) of APOA5 in 232 NAFLD patients and 188 healthy controls were determined using polymerase chain reaction (PCR) analysis...
April 21, 2018: Hepatobiliary & Pancreatic Diseases International: HBPD INT
https://www.readbyqxmd.com/read/29709350/hepatic-fibrosis-it-is-time-to-go-with-hepatic-stellate-cell-specific-therapeutic-targets
#5
Devaraj Ezhilarasan, Etienne Sokal, Mustapha Najimi
Hepatic fibrosis is a pathological lesion, characterized by the progressive accumulation of extracellular matrix (ECM) in the perisinusoidal space and it is a major problem in chronic liver diseases. Phenotypic activation of hepatic stellate cells (HSC) plays a central role in the progression of hepatic fibrosis. Retardation of proliferation and clearance of activated HSCs from the injured liver is an appropriate therapeutic strategy for the resolution and treatment of hepatic fibrosis. Clearance of activated HSCs from the injured liver by autophagy inhibitors, proapoptotic agents and senescence inducers with the high affinity toward the activated HSCs may be the novel therapeutic strategy for the treatment of hepatic fibrosis in the near future...
April 21, 2018: Hepatobiliary & Pancreatic Diseases International: HBPD INT
https://www.readbyqxmd.com/read/29752133/usefulness-of-ca-19-9-for-pancreatic-cancer-screening-in-patients-with-new-onset-diabetes
#6
Jung Wan Choe, Hyo Jung Kim, Jae Seon Kim, Jaehyung Cha, Moon Kyung Joo, Beom Jae Lee, Jong-Jae Park, Young-Tae Bak
BACKGROUND: Generally, carbohydrate antigen 19-9 (CA 19-9) is not useful for screening pancreatic cancer in the asymptomatic general population. This study aimed to evaluate the utility of CA 19-9 level as a screening indicator of pancreatic cancer in asymptomatic patients with new-onset diabetes. METHODS: We retrospectively reviewed the medical records of patients who visited our health promotion center for health check-ups without cancer related symptoms from January 2005 to January 2014, and were newly diagnosed with diabetes mellitus (DM) within 2 years before their visit...
April 20, 2018: Hepatobiliary & Pancreatic Diseases International: HBPD INT
https://www.readbyqxmd.com/read/29655663/announcements-for-this-section-should-be-submitted-in-the-correct-format-at-least-3-months-before-the-required-date-of-publication-this-list-is-provided-as-a-service-to-readers-inclusion-does-not-imply-endorsement-by-the-hepatobiliary-pancreatic-diseases-international
#7
https://www.readbyqxmd.com/read/29739648/prognostic-value-of-decision-criteria-for-emergency-liver-transplantation-in-patients-with-wild-mushroom-induced-acute-liver-injury
#8
Youn-Jung Kim, Hyung Joo Lee, Seung Mok Ryoo, Shin Ahn, Chang Hwan Sohn, Dong-Woo Seo, Kyoung Soo Lim, Won Young Kim
BACKGROUND: The reported mortality rate of mushroom-induced acute liver failure with conventional treatment is 1.4-16.9%. Emergency liver transplantation may be indicated and can be the only curative treatment option. This study aimed to assess the prognostic value of criteria for emergency liver transplantation in predicting 28-day mortality in patients with mushroom-induced acute liver injury. METHODS: A retrospective cohort study was performed between January 2005 and December 2015...
March 30, 2018: Hepatobiliary & Pancreatic Diseases International: HBPD INT
https://www.readbyqxmd.com/read/29631957/prognostic-value-of-postoperative-complication-for-early-recurrence-after-curative-resection-of-hepatocellular-carcinoma
#9
Masataka Amisaki, Hiroaki Saito, Naruo Tokuyasu, Teruhisa Sakamoto, Soichiro Honjo, Yoshiyuki Fujiwara
BACKGROUND: Postoperative complications may adversely affect oncological outcomes. The aim of this study was to evaluate the impact of postoperative complications on early-phase recurrence after curative resection for hepatocellular carcinoma (HCC). METHODS: We included 145 HCC patients who underwent initial and curative resection between January 2004 and December 2013. Postoperative complications of grade III or higher based on Clavien-Dindo classification were defined as clinically relevant postoperative complications...
March 29, 2018: Hepatobiliary & Pancreatic Diseases International: HBPD INT
https://www.readbyqxmd.com/read/29628337/long-term-outcomes-of-endoscopic-papillary-balloon-dilation-for-removal-of-bile-duct-stones-in-billroth-ii-gastrectomy-patients
#10
Tao Li, Jun Wen, Li-Ke Bie, Yi Lu, Biao Gong
BACKGROUND: Endoscopic papillary balloon dilation (EPBD) for common bile duct (CBD) stones removal in Billroth II gastrectomy patients is feasible. However, the long-term outcomes of this technique are not clear. The aim of this study was to evaluate the procedural and long-term outcomes of EPBD for removal of CBD stones in Billroth II gastrectomy patients. METHODS: The records of patients with previous Billroth II gastrectomy referred for CBD stones removal with endoscopic retrograde cholangiopancreatography (ERCP) between July 1, 2008 and September 1, 2016 were retrospectively reviewed...
March 29, 2018: Hepatobiliary & Pancreatic Diseases International: HBPD INT
https://www.readbyqxmd.com/read/29656867/surgical-treatment-of-metachronous-rectal-liver-and-lung-metastases-a-combined-videolaparoscopic-and-videothoracoscopic-approach
#11
LETTER
Francesco Sucameli, Elisa Francone, Laura Dova, Prospero Magistrelli, Emilio Falco, Stefano Berti
No abstract text is available yet for this article.
March 26, 2018: Hepatobiliary & Pancreatic Diseases International: HBPD INT
https://www.readbyqxmd.com/read/29625837/hbsag-stimulates-nkg2d-receptor-expression-on-natural-killer-cells-and-inhibits-hepatitis-c-virus-replication
#12
Xiao-Xiao Wang, Xiao-Ben Pan, Jin-Chao Han, Xu Cong, Qian Jin, Xiang-Sha Kong, Lai Wei, Bo Feng
BACKGROUND: Higher hepatitis B surface antigen (HBsAg) facilitates hepatitis C virus (HCV) clearance in patients with hepatitis B virus (HBV)/HCV co-infection. We investigated the effect of exogenous HBsAg on the inhibition of HCV replication mediated by natural killer (NK) cells. METHODS: After isolated from peripheral blood of 42 chronic hepatitis B (CHB) patients and 16 healthy individuals, NK cells were co-cultured with HCV-infected Huh7 cells, respectively, with or without HBsAg...
March 26, 2018: Hepatobiliary & Pancreatic Diseases International: HBPD INT
https://www.readbyqxmd.com/read/29691136/surgical-treatment-of-metachronous-rectal-liver-and-lung-metastases-a-combined-videolaparoscopic-and-videothoracoscopic-approach
#13
LETTER
Daniele Del Fabbro, Guido Torzilli
No abstract text is available yet for this article.
March 24, 2018: Hepatobiliary & Pancreatic Diseases International: HBPD INT
https://www.readbyqxmd.com/read/29627156/various-approaches-of-laparoscopic-common-bile-duct-exploration-plus-primary-duct-closure-for-choledocholithiasis-a-systematic-review-and-meta-analysis
#14
Ming-Yan He, Xia-Dong Zhou, Hao Chen, Peng Zheng, Fa-Zhan Zhang, Wei-Wei Ren
BACKGROUND: Common bile duct (CBD) stones may occur in up to 3%-14.7% of all patients with cholecystectomy. Various approaches of laparoscopic CBD exploration plus primary duct closure (PDC) are the most commonly used and the best methods to treat CBD stone. This systematic review was to compare the effectiveness and safety of the various approaches of laparoscopic CBD exploration plus PDC for choledocholithiasis. DATA SOURCES: Randomized controlled trials (RCTs) and non-randomized controlled trials (NRCTs) (case-control studies or cohort studies) were searched from Cochrane library (until Issue 2, 2015), Web of Science (1980-January 2016), PubMed (1966-January 2016), and Baidu search engine...
March 24, 2018: Hepatobiliary & Pancreatic Diseases International: HBPD INT
https://www.readbyqxmd.com/read/29627155/alendronate-and-fti-277-combination-as-a-possible-therapeutic-approach-for-hepatocellular-carcinoma-an-in-vitro-study
#15
Amber Ilyas, Zehra Hashim, Iffat Saeed Channa, Shamshad Zarina
BACKGROUND: An important product of mevalonate pathway is downstream synthesis of isoprenoid units that has long been implicated in development and progression of tumor. It has been speculated that inhibition of protein prenylation might be therapeutically beneficial. The objective of current study was to evaluate antitumor potential of a novel therapeutic combination of mevalonate pathway inhibitors, FTI-277 and alendronate. We also examined differentially expressed proteins in response to treatment using proteomics approach...
March 24, 2018: Hepatobiliary & Pancreatic Diseases International: HBPD INT
https://www.readbyqxmd.com/read/29625836/restoration-of-common-bile-duct-diameter-within-2-weeks-after-endoscopic-stone-retraction-is-a-preventive-factor-for-stone-recurrence
#16
Jin Jeon, Sung Uk Lim, Chang-Hwan Park, Chung-Hwan Jun, Seon-Young Park, Jong-Sun Rew
BACKGROUND: Little information is available about the relationship between restoration of common bile duct (CBD) diameter after endoscopic stone retraction and recurrence of CBD stones in elderly patients. The present study was to determine whether restoration of CBD diameter is a preventive factor for CBD stone recurrence in elderly patients who underwent endoscopic retrograde cholangiopancreatography (ERCP). METHODS: From January 2006 to December 2010, 238 patients underwent the first and the second session of ERCP for the removal of CBD stones...
March 24, 2018: Hepatobiliary & Pancreatic Diseases International: HBPD INT
https://www.readbyqxmd.com/read/29709351/expression-of-hepatic-wnt5a-and-its-clinicopathological-features-in-patients-with-hepatocellular-carcinoma
#17
Li Wang, Min Yao, Miao Fang, Wen-Jie Zheng, Zhi-Zhen Dong, Liu-Hong Pan, Hai-Jian Zhang, Deng-Fu Yao
BACKGROUD: Wingless-type MMTV integration site family member 5a (Wnt5a) is involved in carcinogenesis. However, little data are available in Wnt5a signaling with hepatocellular carcinoma (HCC). In the present study, we investigated the expression of hepatic Wnt5a in HCC and the role of Wnt5a in HCC progression and outcome. METHODS: Wnt5a expression and cellular distribution in HCCs and their matched paracancerous tissues from 87 patients were analyzed with tissue microarray and immunohistochemistry and compared with hepatic Wnt3a signaling...
March 13, 2018: Hepatobiliary & Pancreatic Diseases International: HBPD INT
https://www.readbyqxmd.com/read/29576277/the-clinicopathological-and-prognostic-significance-of-pd-l1-expression-in-pancreatic-cancer-a-meta-analysis
#18
He-Li Gao, Liang Liu, Zi-Hao Qi, Hua-Xiang Xu, Wen-Quan Wang, Chun-Tao Wu, Shi-Rong Zhang, Jin-Zhi Xu, Quan-Xing Ni, Xian-Jun Yu
BACKGROUND: Immunotherapy has shown promise against solid tumors. However, the clinical significance of programmed cell death 1 (PD-1) and programmed cell death ligand 1 (PD-L1) in pancreatic ductal adenocarcinoma (PDAC) remains unclear. This meta-analysis aimed to analyze the prognostic effect of PD-L1 in PDAC. DATA SOURCES: Electronic search of the PubMed, Cochrane Library and Web of Science was performed until December 2016. Through database searches, we identified articles describing the relationship between PD-L1 status and PDAC patient prognosis...
March 13, 2018: Hepatobiliary & Pancreatic Diseases International: HBPD INT
https://www.readbyqxmd.com/read/29571649/prediction-of-tumor-biological-characteristics-in-different-colorectal-cancer-liver-metastasis-animal-models-using-18-f-fdg-and-18-f-flt
#19
Hai-Long Xu, Man Li, Rong-Jun Zhang, Hui-Jie Jiang, Ming-Yu Zhang, Xin Li, Yi-Qiao Wang, Wen-Bin Pan
BACKGROUND: Positron emission tomography (PET) is a noninvasive method to characterize different metabolic activities of tumors, providing information for staging, prognosis, and therapeutic response of patients with cancer. The aim of this study was to evaluate the feasibility of18 F-fludeoxyglucose (18 F-FDG) and 3'-deoxy-3'-18 F-fluorothymidine (18 F-FLT) PET in predicting tumor biological characteristics of colorectal cancer liver metastasis. METHODS: The uptake rate of18 F-FDG and18 F-FLT in SW480 and SW620 cells was measured via an in vitro cell uptake assay...
March 13, 2018: Hepatobiliary & Pancreatic Diseases International: HBPD INT
https://www.readbyqxmd.com/read/29576280/combination-of-tumor-associated-regulatory-t-cell-deletion-and-pd-1-pd-l1-blockade-a-promising-immunotherapy-for-hepatocellular-carcinoma
#20
EDITORIAL
Hua-Yu Yang, Le-Jia Sun, Yi-Lei Mao
No abstract text is available yet for this article.
March 8, 2018: Hepatobiliary & Pancreatic Diseases International: HBPD INT
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