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Journals Metabolic Syndrome and related...

Metabolic Syndrome and related Disorders

https://read.qxmd.com/read/38170182/timing-of-initiation-of-xanthine-oxidase-inhibitors-based-on-serum-uric-acid-level-does-not-predict-renoprognosis-in-patients-with-preserved-kidney-function
#21
JOURNAL ARTICLE
Atsushi Takayama, Toshiki Fukasawa, Masato Takeuchi, Koji Kawakami
Background: Despite recent evidence of remaining possibility that early initiation of xanthine oxidase inhibitors (XOIs) is beneficial in renoprognosis for patients with stage 2 or less chronic kidney disease (CKD), no evidence is available regarding the difference in renoprognosis based on serum uric acid (sUA) levels at the initiation of XOIs among patients with preserved kidney function. Methods: New XOI initiators were divided into quartiles based on baseline sUA. Primary outcome was the composite incidence of a significant estimated glomerular filtration rate (eGFR) decline (≥40% decline in eGFR from baseline or development of eGFR <30 mL/1...
January 3, 2024: Metabolic Syndrome and related Disorders
https://read.qxmd.com/read/38165660/effect-of-teneligliptin-20%C3%A2-mg-twice-daily-on-glucagon-like-peptide-1-levels-and-its-influence-on-non-glycemic-components-in-non-diabetic-obese-individuals
#22
JOURNAL ARTICLE
Ranakishor Pelluri, Srikanth Kongara, Vanitha Rani Nagasubramanian, Shriraam Mahadevan, Jithendra Chimakurthy
Background and Aims: Teneligliptin is an oral antidiabetic agent, it can persevere glucagon-like peptide-1 (GLP-1) by inhibiting dipeptidyl peptidase enzyme. In addition, it has rare incidence of hypoglycemia. Hence, this study aimed to test the effect of teneligliptin 20 mg twice daily along with low carbohydrate diet and physical exercise on change of body weight and insulin resistance in nondiabetic obese subjects. Materials and Methods: It is a prospective, randomized, double-blind, placebo-controlled, parallel group study carried out at outpatient department of an endocrinology hospital over the period of 48 weeks...
January 3, 2024: Metabolic Syndrome and related Disorders
https://read.qxmd.com/read/38156816/acknowledgment-of-reviewers-2023
#23
JOURNAL ARTICLE
(no author information available yet)
No abstract text is available yet for this article.
December 29, 2023: Metabolic Syndrome and related Disorders
https://read.qxmd.com/read/38153394/prediction-and-validation-of-metabolic-dysfunction-associated-fatty-liver-disease-using-fatty-liver-related-indices-in-a-japanese-population
#24
JOURNAL ARTICLE
Kengo Moriyama
Background: Recently, metabolic dysfunction-associated fatty liver disease (MAFLD) has been proposed. It is uncertain how indices that predict fatty liver are associated with MAFLD in Japanese. Methods: Among subjects who underwent a health examination at our hospital, 1257 (men: 787, women: 474) subjects participated in fatty liver evaluation of the fatty liver index (FLI) and fatty liver predicting index (FLPI) were included in this cross-sectional study. The discriminatory ability of each index for MAFLD was tested using receiver operating characteristic curve analysis...
December 28, 2023: Metabolic Syndrome and related Disorders
https://read.qxmd.com/read/38133543/triglyceride-glucose-index-and-its-correlates-associations-with-serum-creatinine-and-estimated-glomerular-filtration-rate-in-a-cross-sectional-study-from-charls-2011-2015
#25
JOURNAL ARTICLE
Lei Li, Zichen Xu, Luqing Jiang, Lingdan Zhuang, Jianjun Huang, Daoqin Liu, Qiwen Wu
Background: Chronic kidney disease (CKD) has emerged as a significant global public health challenge, and the estimated glomerular filtration rate (eGFR) is widely used due to its convenience, low cost, and broad clinical applicability. Concurrently, insulin resistance (IR) serves as a crucial marker of metabolic disturbance, and alternative indicators have garnered increasing attention in CKD research in recent years. Objective: This study aims to investigate the relationship between IR-related indices (TyG index, TyG-BMI index, and TyG-WC index) and serum creatinine levels, as well as the eGFR, with the intention of uncovering their potential roles in the assessment of renal function...
December 22, 2023: Metabolic Syndrome and related Disorders
https://read.qxmd.com/read/38350086/associating-liver-enzymes-and-their-interactions-with-metabolic-syndrome-prevalence-in-a-japanese-working-population
#26
JOURNAL ARTICLE
Aziz Jamal, Akira Babazono, Ning Liu, Rieko Yamao, Takako Fujita, Sung-A Kim, Yunfei Li
Background: Serum gamma-glutamyltransferase (γ-GT), alanine aminotransferase (ALT), and aspartate aminotransferase (AST) levels often increase in metabolic diseases. Objective: This study was conducted to determine which liver enzymes are strongly associated with metabolic syndrome (MetS), how they interact to produce different probability estimates, and what cutoff levels should be used to guide clinical decision-making. Methods: The researchers examined the insurance-based medical checkup data of 293,610 employees ≥35 years years of age, who underwent medical checkups between April 1, 2016, and March 31, 2017...
February 2024: Metabolic Syndrome and related Disorders
https://read.qxmd.com/read/38350085/acknowledgment-of-reviewers-2023
#27
JOURNAL ARTICLE
(no author information available yet)
No abstract text is available yet for this article.
February 2024: Metabolic Syndrome and related Disorders
https://read.qxmd.com/read/38011534/associations-of-alanine-aminotransferase-aspartate-aminotransferase-a-marker-of-hepatosteatosis-with-adipose-tissue-insulin-resistance-index-and-leptin-adiponectin-ratio-in-japanese-women
#28
JOURNAL ARTICLE
Satomi Minato-Inokawa, Ayaka Tsuboi-Kaji, Mari Honda, Mika Takeuchi, Kaori Kitaoka, Miki Kurata, Bin Wu, Tsutomu Kazumi, Keisuke Fukuo
Objective: We assessed whether alanine aminotransferase/aspartate aminotransferase (ALT/AST), a marker of hepatic steatosis, may be associated with adipose tissue dysfunction more closely than hepatic and muscle insulin resistance (IR). Methods: Associations with adipose tissue IR index (AT-IR) calculated as a product of fasting insulin and free fatty acids, leptin/adiponectin ratio, a proxy of adipocyte dysfunction, homeostasis model assessment IR (HOMA-IR), hepatic and muscle IR inferred from plasma insulin kinetics during a 75 grams oral glucose tolerance test (OGTT) were studied in nondiabetic 307 young and 148 middle-aged Japanese women, whose body mass index averaged 20 and 22 kilograms/m2 , respectively...
December 2023: Metabolic Syndrome and related Disorders
https://read.qxmd.com/read/37883666/serum-vaspin-levels-in-gestational-diabetes-mellitus-a-meta-analysis
#29
REVIEW
Bo Zhou, Yibu Liu, Yibing Ren, Xuehui Yan, Judi Fan, Lei Tang, Min Wen
The objective of this study was to evaluate the potential relationship between serum vaspin levels and gestational diabetes mellitus (GDM). The PubMed, EBSCO, Web of Science, the Cochrane Library, and the China National Knowledge Infrastructure (CNKI) database were searched for articles published before December 2022. The publication language was restricted to English and Chinese. A meta-analysis was conducted by combining all studies that met the inclusion and exclusion criteria. Twenty-two studies (1990 women with GDM and 1597 pregnant women without GDM) were ultimately included in this meta-analysis...
December 2023: Metabolic Syndrome and related Disorders
https://read.qxmd.com/read/37816229/metabolic-syndrome-an-overview-on-its-genetic-associations-and-gene-diet-interactions
#30
REVIEW
Denisse Prone-Olazabal, Ian Davies, Faviel Francisco González-Galarza
Metabolic syndrome (MetS) is a cluster of cardiometabolic risk factors that includes central obesity, hyperglycemia, hypertension, and dyslipidemias and whose inter-related occurrence may increase the odds of developing type 2 diabetes and cardiovascular diseases. MetS has become one of the most studied conditions, nevertheless, due to its complex etiology, this has not been fully elucidated. Recent evidence describes that both genetic and environmental factors play an important role on its development. With the advent of genomic-wide association studies, single nucleotide polymorphisms (SNPs) have gained special importance...
December 2023: Metabolic Syndrome and related Disorders
https://read.qxmd.com/read/37768731/low-density-lipoprotein-cholesterol-is-not-a-major-determinant-of-high-sensitivity-c-reactive-protein-levels-in-people-without-known-diabetes-mellitus
#31
JOURNAL ARTICLE
Guan-Yu Su, Ng Xin Ning, Kuan-Hung Lin, Chii-Min Hwu
Background: It has been well established that high-sensitivity C-reactive protein (hs-CRP) is strongly associated with obesity, insulin resistance, high blood pressure, and dyslipidemia. However, the effects of different lipid parameters on hs-CRP levels are less deliberated. The purpose of the study was to compare the relative contribution of triglycerides (TGs), low-density lipoprotein cholesterol (LDL-C), and high-density lipoprotein cholesterol (HDL-C) to the levels of hs-CRP. Methods: Three hundred seventy-eight subjects without known history of diabetes were recruited for the study...
December 2023: Metabolic Syndrome and related Disorders
https://read.qxmd.com/read/38011536/lifestyle-and-health-behaviors-associated-with-metabolic-syndrome-and-cardiovascular-disease
#32
JOURNAL ARTICLE
Goeun Chung, Hye-Jin Kim
Background: As the prevalence of cardiovascular disease increases, the socioeconomic burden is expected to increase further. This study aimed to investigate lifestyle and health behaviors related to metabolic syndrome (MetS), myocardial infarction (MI), and stroke prevalence in men and women 50-79 years of age to assess clustering of risk factors. Methods: This study used raw data from the eighth Korea National Health and Nutrition Examination Survey (KNHANES) in 2021. Collected data were analyzed using SPSS 29...
November 22, 2023: Metabolic Syndrome and related Disorders
https://read.qxmd.com/read/37971853/investigation-of-the-relationship-between-serum-low-density-lipoprotein-cholesterol-levels-with-genetic-polymorphisms-gut-microbiota-and-nutrition
#33
JOURNAL ARTICLE
Asu Şevval Dural, Can Ergün, Murat Urhan
Background: To prevent cardiovascular disease (CVD), it is important to determine the factors that are associated with its development. High serum low-density lipoprotein (LDL) cholesterol (LDL-C) levels are a modifiable prevention and treatment target known to contribute to the development of CVD, but the factors affecting blood cholesterol levels, including LDL-C, remain controversial. Objective: In this study, the factors (genetic, nutritional, and gut microbiota) thought to be effective on serum LDL-C levels were discussed from a holistic perspective, and the effects of the relationship between these factors on LDL-C levels were examined...
November 16, 2023: Metabolic Syndrome and related Disorders
https://read.qxmd.com/read/37944109/the-inverse-association-between-isoflavone-intake-and-prevalence-of-metabolic-syndrome-a-cross-sectional-study-from-national-health-and-nutrition-examination-survey
#34
JOURNAL ARTICLE
Feng Yuan, Qingya Zeng, Yanuo Hu, Jixing Liang
Objective: Metabolic syndrome (MetS) is a global disease burden that has resulted in 10 million people being affected by it, yet no new drugs have been approved for clinical treatment. Isoflavone may be able to stop the development of MetS or enhance its treatment. Therefore, we investigated the relationship between dietary intake of isoflavone and prevalence of MetS to find potentially effective treatments. Methods: We conducted a cross-sectional study using data from 8512 National Health and Nutrition Examination Survey (NHANES) participants from 2007 to 2010 and 2017 to 2018 and their associated isoflavone intake from the flavonoid database in the USDA Food and Nutrient Database for Dietary Studies (FNDDS)...
November 10, 2023: Metabolic Syndrome and related Disorders
https://read.qxmd.com/read/37944108/effects-of-metabolic-syndrome-and-its-components-on-chronic-kidney-disease-and-renal-function-a-two-sample-mendelian-randomization-study
#35
JOURNAL ARTICLE
Huazhao Yang, Zhenhua Cui, Zhenyu Quan
Objective: The association of metabolic syndrome (MetS) and its components with chronic kidney disease (CKD) and renal function remains controversial in observational studies. To comprehensively investigate the association between MetS and its components with CKD and renal function, a Mendelian randomization (MR) study was performed. Methods: The inverse variance weighting (IVW) of random effects was used as the main estimation method, while MR-Egger and weighted median analysis results were used for auxiliary judgments...
November 10, 2023: Metabolic Syndrome and related Disorders
https://read.qxmd.com/read/37902791/the-role-of-remnant-cholesterol-beyond-low-density-lipoprotein-cholesterol-in-arterial-stiffness-a-cross-sectional-study
#36
JOURNAL ARTICLE
Peng Zhang, Jinfeng Ma, Daojing Li, Qiuhua Li, Ziyou Qi, Peng Xu, Lixia Liu, Hongfang Li, Aimei Zhang
Background: Previous evidence has demonstrated that elevated low-density lipoprotein cholesterol (LDL-C) was associated with atherosclerosis. However, there is scarce population-based evidence for the role of remnant cholesterol (remnant-C) in arterial stiffness, an imaging marker for subclinical atherosclerosis. Herein, we aimed to evaluate the correlation of remnant-C with arterial stiffness beyond LDL-C in a check-up population. Methods: The study included consecutive subjects who visited the Murakami Memorial Hospital for health check-ups between 2004 and 2012...
October 30, 2023: Metabolic Syndrome and related Disorders
https://read.qxmd.com/read/37883657/serum-lipoprotein-a-is-not-associated-with-graves-ophthalmopathy
#37
JOURNAL ARTICLE
Cem Sulu, Selin Ece Dedeoglu, Busenur Gonen, Mustafa Hepkour, Adnan Nuri Guzel, Serdar Sahin, Ahmet Numan Demir, Zehra Kara, Dildar Konukoglu, Taner Damci, Mustafa Sait Gonen
Aim: To investigate the relationship of serum lipoprotein(a) [Lp(a)] and other serum lipids with presence of Graves' ophthalmopathy (GO). Methods: A total of 99 consecutive patients diagnosed with Graves' disease (GD), aged 18-65 years, who had not received prior treatment for GO, thyroid surgery, or radioactive iodine therapy, were recruited between June 2020 and July 2022. In addition, 56 healthy controls (HCs) were included as the control group. All patients underwent an ophthalmological examination, and were classified based on the presence of GO into the GO group ( n  = 45) and no GO group ( n  = 54)...
October 26, 2023: Metabolic Syndrome and related Disorders
https://read.qxmd.com/read/37878804/prediction-and-validation-of-metabolic-dysfunction-associated-fatty-liver-disease-using-insulin-resistance-related-indices-in-the-japanese-population
#38
JOURNAL ARTICLE
Kengo Moriyama, Nagamu Inoue, Jin Imai, Yumi Masuda, Chizumi Yamada, Noriaki Kishimoto, Shinji Takashimizu, Akira Kubo, Yasuhiro Nishizaki
Background: Recently, metabolic dysfunction-associated fatty liver disease (MAFLD), which is based on evidence of hepatic steatosis and any of the following three conditions: overweight/obesity, presence of type 2 diabetes mellitus, or evidence of metabolic dysregulation, has been proposed. It is uncertain how indices that predict insulin resistance (IR) are associated with MAFLD. Methods: Among subjects who had undergone health examinations at our hospital, 1,257 (787 men and 474 women) who underwent fatty liver evaluation, were included in this cross-sectional study...
October 25, 2023: Metabolic Syndrome and related Disorders
https://read.qxmd.com/read/37878791/relationship-between-perivascular-adipose-tissue-and-cardiovascular-risk-factors-a-systematic-review-and-meta-analysis
#39
JOURNAL ARTICLE
Anna Bragina, Yulia Rodionova, Natalia Druzhinina, Alexandr Suvorov, Konstantin Osadchiy, Tatiana Ishina, Maria Vasilchenko, Milena Khalenyan, Selen Dishkaya, Valeriy Podzolkov
We conducted a systematic review and meta-analysis aimed at estimating the association between perivascular adipose tissue (PVAT) and some of the cardiovascular risk factors. A systematic search was conducted from January 1980 up to and including 2022 to identify studies that examined the relationship between PVAT and cardiovascular risk factors as obesity and its indices, hypertension, lipids, and glucose intolerance/diabetes. The Medline and Embase databases were searched using the PubMed and Scopus. Data were extracted from 23 studies that fit the criteria...
October 25, 2023: Metabolic Syndrome and related Disorders
https://read.qxmd.com/read/37878298/dynapenic-abdominal-obesity-and-metabolic-health-in-non-geriatric-patients-with-obesity
#40
JOURNAL ARTICLE
Feray Akbas, Hanife Usta Atmaca, Dilek Yazici
Background: Dynapenic abdominal obesity (DAO) is the combination of low muscle strength and high central adiposity, which can lead to functional and cardiometabolic impairments. Objective: The aim of this study was to examine the relationship between DAO and metabolic parameters in non-geriatric patients with obesity. Methods: All patients seen in the obesity outpatient clinic during a random month, along with 30 healthy individuals, were included in the study. Body mass index (BMI), waist circumference (WC), hip circumference (HC), serum fasting blood glucose, triglyceride, high-density lipoprotein, low-density lipoprotein (LDL), insulin, and glycated hemoglobin (HbA1c) levels were measured...
October 25, 2023: Metabolic Syndrome and related Disorders
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