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Metabolic Syndrome and related Disorders

Rodrigo Fonseca-Portilla, Janina Krell-Roesch, Gabriel Q Shaibi, Richard J Caselli, Lawrence J Mandarino, Nan Zhang, Joseph G Hentz, Dawn K Coletta, Elena Anna de Filippis, Sara Dawit, Yonas E Geda
BACKGROUND: Brain-derived neurotrophic factor (BDNF) is associated with body weight and other health conditions but remains understudied in the Latino population. The aim of this study was to examine the associations of BDNF serum levels with body mass index (BMI), physical activity, and the rs6265 nonconservative polymorphism among 349 Latinos aged ≥18 years enrolled in the Arizona Insulin Resistance Registry. MATERIALS AND METHODS: Data on physical activity were acquired using a self-reported questionnaire...
November 10, 2018: Metabolic Syndrome and related Disorders
Young Sammy Choi, John S Klaric, Thomas H Beltran
BACKGROUND: Adolescent obesity is an important risk factor for cardiovascular disease in part due to its relationship to type 2 diabetes. Therefore, screening for type 2 diabetes is recommended. However, since insulin resistance (IR) is an early precursor of diabetes, it would be beneficial if IR predictors from routine assessments could identify those at greatest metabolic risk before diabetes has developed. METHODS: Adolescents aged 14-18 years with normal fasting plasma glucose (n = 252) were selected from the National Health and Nutrition Examination Survey 2013-2014...
November 3, 2018: Metabolic Syndrome and related Disorders
Paolo Degan, Enrico Cappelli, MariaGrazia Longobardi, Alessandra Pulliero, Paola Cuccarolo, Carlo Dufour, Silvia Ravera, Daniela Calzia, Alberto Izzotti
PURPOSE: Fanconi anemia (FA) is a complex tumor-prone disease defined by an entangled genotype and phenotype. Despite enormous efforts in the last 20 years, a comprehensive and integrated view of the disease is still missing. The aim of this pilot study was to establish whether a global microRNA (miRNA) analysis approach could be helpful in defining aspects in FA phenotype, which might deserve future attention with the perspective to develop miRNA-based therapies. METHODS: miRNA array were employed to characterize the global miRNA (miRNoma) profile of FA RNA samples with respect to normal samples...
October 30, 2018: Metabolic Syndrome and related Disorders
Thirumagal Kanagasabai, Khloud Alkhalaqi, James R Churilla, Chris I Ardern
BACKGROUND: Clinical reference ranges are often used to assess nutritional status, but whether having lower or higher than the current clinical reference range for micronutrients, inflammation, and oxidative stress is related to metabolic syndrome (MetS) is not known. Our objectives are to estimate the odds of having MetS outside of established clinical references, and to identify any effect modifications by sex for these relationships. METHODS: Data from the 2005 to 2006 National Health and Nutrition Examination Survey were used (≥20 years; N = 2049) with MetS defined utilizing the harmonized criteria from the Joint Interim Statement...
October 27, 2018: Metabolic Syndrome and related Disorders
Yu-Huei Li, Chieh-Hua Lu, Fu-Huang Lin, Sheng-Chiang Su, Jhih-Syuan Liu, Chang-Hsun Hsieh, Yi-Jen Hung, Yi-Shing Shieh, Chien-Hsing Lee
BACKGROUND: Growth arrest-specific 6 (Gas6) is a vitamin K-dependent protein secreted by immune cells, endothelial cells, vascular smooth muscle cells, and adipocytes. Recent studies indicate that Gas6 and receptors of the TAM (Tyro3, Axl, and Mer) family may be involved in the pathogenesis of obesity, systemic inflammation, and insulin resistance. The aim of this study was to investigate the association between plasma Gas6 protein and the c.843 + 7G>A Gas6 polymorphism in metabolic syndrome (MetS)...
October 20, 2018: Metabolic Syndrome and related Disorders
Rohan K Henry
In addition to its growth promoting role, growth hormone (GH) has a significant effect on intermediary metabolism in the well state. Despite the latter fact, pediatric practitioners are usually focused on the growth promoting aspects of GH as opposed to those metabolic. In recent years various animal and human studies (in adults mainly) and clinical reports in children have repeatedly shown the association of GH deficiency (GHD) and fatty liver disease. Based on this well-identified association, despite a lack of studies involving children, it behooves the pediatric clinician to ensure that not only patients with GHD are appropriately treated but also that adolescents even beyond the period of linear growth should be appropriately transitioned to adult GH therapy should this be appropriate...
October 20, 2018: Metabolic Syndrome and related Disorders
Fabrício Edler Macagnan, Ana Maria Pandolfo Feoli, Thais Russomano
BACKGROUND: There is little evidence of how metabolic syndrome (MS) affects sympathovagal balance responses to acute physical effort (APE) and autonomic stimulation (AS). This study aimed to evaluate the heart rate variability (HRV) responses to the combined APE and AS challenges. METHODS: Fourteen subjects (8 men; 49.15 ± 8.67 years) divided into two groups: 7 healthy volunteers [control group (CG)] and 7 patients with MS. Sympathovagal balance [low frequency (LF)/high frequency (HF) ratio] was accessed by HRV through the beat-to-beat heart rate (HR) electrocardiogram...
October 17, 2018: Metabolic Syndrome and related Disorders
Mia Demant, Jonatan I Bagger, Malte P Suppli, Asger Lund, Mette Gyldenløve, Katrine B Hansen, Kristine J Hare, Mikkel Christensen, David P Sonne, Jens J Holst, Tina Vilsbøll, Filip K Knop
BACKGROUND: Fasting hyperglucagonemia can be detrimental to glucose metabolism in patients with type 2 diabetes (T2D) and may contribute to metabolic disturbances in obese and/or prediabetic subjects. However, the mechanisms underlying fasting hyperglucagonemia remain elusive. METHODS: We evaluated the interrelationship between fasting hyperglucagonemia and demographic and biochemical parameters in 106 patients with T2D (31% female, age: 57 ± 9 years [mean ± standard deviation; body mass index (BMI): 30...
October 16, 2018: Metabolic Syndrome and related Disorders
Michael Palacios-Mendoza, Maria Beatriz Jurado, Ximena Gamboa, Carlos Cevallos, Daniel Moreno-Zambrano, Maria Carolina Duarte, Carlos Penaherrera, Leonardo Tamariz, Ana Palacio, Rocio Santibanez
BACKGROUND: Diabetes is a major contributor to dementia in the elderly. Identifying mild cognitive decline in younger individuals with diabetes could aid in preventing the progression of the disease. The aim of our study is to compare whether patients with diabetes experience greater cognitive decline than those without diabetes. METHODS: We conducted a cross-sectional study using population-based recruitment to identify a cohort of individuals with diabetes and corresponding control group without diabetes of 55-65 years of age...
October 11, 2018: Metabolic Syndrome and related Disorders
Cristina Nita, Adriana Rusu, Nicolae Hancu, Gabriela Roman, Cornelia Bala
No abstract text is available yet for this article.
October 6, 2018: Metabolic Syndrome and related Disorders
Sang Yoon Lee, Won Kim, Shi-Uk Lee, Kyoung Hyo Choi
BACKGROUND: Although several studies have shown that obesity affects low back pain (LBP), the relationship between degenerative lumbar spine (LSD) and obesity has not been fully investigated. This study evaluated whether obesity is independently associated with LSD in the general population. METHODS: This cross-sectional study used public data from the Fifth Korean National Health and Nutrition Examination Survey (2010-2012). Subjects aged ≥50 years who had completed surveys were included (3668 men and 4966 women)...
October 6, 2018: Metabolic Syndrome and related Disorders
Syed Amirfaiz, Mohd Razif Shahril
Objective measurement of physical activity (PA) and sedentary behavior (SB) associated with metabolic syndrome (MetS) has gained more attention among researchers in recent years. Although almost similar trends of results have been reported worldwide, they were not always statistically significant. This systematic review summarizes the evidence of observational studies reporting the associations between objectively measured PA, SB, and MetS in adults. Registration in PROSPERO was made (CRD42017078929). Literature search was conducted in the PubMed database for observational studies associating objectively measured PA and SB with MetS among adults...
September 29, 2018: Metabolic Syndrome and related Disorders
Eytan Cohen, Ili Margalit, Elad Goldberg, Ilan Krause
BACKGROUND: Overweight and obesity are more common in men than in women. This explains the higher prevalence of risk factors for metabolic syndrome (MetS) found in men. We aimed to assess whether gender, per se, might be an independent risk factor for the components of MetS in a large cohort of subjects within the normal range of body mass index (BMI). MATERIALS AND METHODS: Cross-sectional analysis was carried out on 9976 men and women, aged 18 to 70 years, with a BMI between 18...
September 11, 2018: Metabolic Syndrome and related Disorders
Şahbender Koç, Selçuk Baysal, Zuhal Koç, Arif Ülkü Yener
BACKGROUND: Glycated hemoglobin (HbA1c) is an index of the average blood glucose level over the preceding 2-3 months. In experimental studies, the lens responded to changes in osmolarity by forming vacuoles. By observing the vacuoles of the lens during eye examination, can we detect changes in osmolarity and glycemia over the last 6 months through HbA1c levels? METHODS: In total, 400 patients (mean age, 67.7 ± 9.8 years), including those with diabetes mellitus, hypertension, and heart failure, were included in the study...
September 5, 2018: Metabolic Syndrome and related Disorders
Maciej Haberka, Katarzyna Stolarz-Skrzypek, Małgorzata Biedroń, Karolina Szóstak-Janiak, Małgorzata Partyka, Magdalena Olszanecka-Glinianowicz, Zbigniew Gąsior
BACKGROUND: Hypertension and obesity are very common and complex cardiovascular (CV) risk factors. Our aim was to provide a comprehensive assessment of associations between visceral fat depots and vascular or cardiac complications of hypertension. METHODS: All the consecutive patients (age: 45-80 years old) scheduled for elective coronary angiography in the Department of Cardiology were screened, and 400 patients were included into the study group. All the patients had a comprehensive clinical assessment focused on hypertension and obesity, risk factors, fat depots, and several hypertension-related vascular or cardiac complications...
September 5, 2018: Metabolic Syndrome and related Disorders
Hyun Joo Lee, Hyun Nyung Jo, Yun Hwa Kim, Seung Chul Kim, Jong Kil Joo, Kyu Sup Lee
BACKGROUND: The aim of this study is to investigate the value of clinical indicators of metabolic syndrome according to menopausal status in healthy Korean women. METHODS: The study included 3936 female patients who were managed at Pusan National University Hospital Health Promotion Center from 2008 to 2014. Each patient completed self-report questionnaires and underwent personal interviews with a healthcare provider to assess their past medical history such as any previous disease, medication and/or menstrual histories along with the measurement of her current body size...
November 2018: Metabolic Syndrome and related Disorders
Angela Cozma, Adela Sitar-Taut, Olga Orăşan, Daniel Leucuta, Teodora Alexescu, Adina Stan, Vasile Negrean, Dorel Sampelean, Dana Pop, Dumitru Zdrenghea, Romana Vulturar, Adriana Fodor
BACKGROUND: Metabolic syndrome (MS) is a clustering entity characterized by obesity, hypertension, hyperglycemia, dyslipidemia, and insulin resistance. Early detection of atherosclerosis is important in patients with MS because cardiovascular diseases are the main cause of mortality in these patients. METHODS: We aimed to investigate the factors influencing arterial stiffness, pulse wave velocity, and the augmentation index, respectively, in 150 subjects with MS (94 women and 56 men; mean age 60...
November 2018: Metabolic Syndrome and related Disorders
Andrea Santi, Tyler A Bosch, Anne E Bantle, Alison Alvear, Qi Wang, James S Hodges, Donald R Dengel, Lisa S Chow
BACKGROUND: Despite the benefits of aerobic exercise on body composition, runners with high body mass index (BMI) remain understudied. We examined body composition differences between sedentary insulin-resistant [obese insulin-resistant sedentary (OS-IR)], sedentary insulin-sensitive [obese insulin-sensitive sedentary (OS-IS)], and trained [obese trained (OT)] individuals with high BMI (≥25 kg/m2 ). We hypothesized that after matching for high BMI, OT individuals would have less fat mass (absolute and relative) and greater lean mass than OS-IR or OS-IS individuals...
November 2018: Metabolic Syndrome and related Disorders
Kayoung Lee
BACKGROUND: The association of handgrip strength with nonalcoholic fatty liver disease (NAFLD) has not been studied yet. This study investigated the relationship between handgrip strength and NAFLD in South Korean adults. METHODS: Referring to the Korea National Health and Nutrition Examination Survey 2014 and 2015 database, South Korean adults (n = 8001, women: 55.5%) aged 19-80 years having complete data were considered for this study. Relative handgrip strength (RHGS) [average handgrip strength of both hands divided by body mass index (BMI)], hepatic steatosis index (HSI), BMI, and components of metabolic syndrome were measured...
November 2018: Metabolic Syndrome and related Disorders
Courtney L Millar, Quinn Duclos, Chelsea Garcia, Gregory H Norris, Bruno S Lemos, Diana M DiMarco, Maria Luz Fernandez, Christopher N Blesso
BACKGROUND: High-density lipoprotein (HDL) particles are protective against atherosclerosis. However, HDL function is impaired in metabolic syndrome (MetS) due to low-grade inflammation and dyslipidemia. Foods containing polyphenols, such as grapes, may prevent HDL dysfunction via antioxidant or anti-inflammatory effects. We evaluated the effects of grape powder ingestion on measures of HDL function in adults with MetS. METHODS: Twenty adults (age: 32-70 years; body mass index: 25...
November 2018: Metabolic Syndrome and related Disorders
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