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Metabolic Syndrome and related Disorders

Erin M Shellington, Sonja M Reichert, Robert J Petrella
Type 2 diabetes mellitus (T2DM) imparts an increased risk for cognitive decline, specifically executive function, which is important to maintain for diabetes self-management. There is evidence to suggest that exercise improves cognition in healthy older adults; however, the literature in adults with T2DM is lacking. This commentary is in complement to Podolski et al.'s systematic review evaluating the effects of physical activity on cognitive function in adults with T2DM. We have included eight additional studies and further highlight their conclusions on the heterogeneity of the literature thus far...
May 16, 2018: Metabolic Syndrome and related Disorders
Gustavo Mora-García, Doris Gómez-Camargo, Ángelo Alario, Claudio Gómez-Alegría
BACKGROUND: The caveolin 1 (CAV1) gene has been associated with metabolic traits in animal models and human cohorts. Recently, a prevalent variant in CAV1 has been found to be related to metabolic syndrome in Hispanics living in North America. Since Hispanics represent an admixed population at high risk for cardiovascular diseases, in this study a Latin American population with a similar genetic background was assessed. OBJECTIVE: To analyze a genetic association between CAV1 and metabolic traits in an admixed Latin American population...
May 15, 2018: Metabolic Syndrome and related Disorders
Janet M Wojcicki, Deena Elwan, Jue Lin, Elizabeth Blackburn, Elissa Epel
AIMS: Shorter telomere length is associated with increased chronic disease risk in adulthood including diabetes mellitus and cardiovascular risk. Few studies have evaluated the relationship between telomere length change and incident disease risk in populations with a high percentage of overweight and obesity. RESULTS: In an urban Latina population recruited in San Francisco (n = 82) with a high prevalence of overweight and obesity (78.4%), we assessed leukocyte telomere length and telomere length change over a 1-year period in relation to obesity, chronicity of obesity, and incident metabolic disease risk 5-6 years later...
May 11, 2018: Metabolic Syndrome and related Disorders
Yoo Mee Kim, Sunghoon Kim, Se Hwa Kim, Young Jun Won
BACKGROUND: Obesity and metabolic syndrome (MetS) are increasing rapidly worldwide, but metabolically healthy population exists. Thus, this study evaluated the proportion of obesity and MetS and investigated clinical and body compositional factors associated with MetS in obese Koreans. METHODS: This cross-sectional observational study enrolled subjects from the Korea National Health and Nutrition Examination Survey (n = 15,408). Obesity was defined by body mass index (BMI) cutoff points of 25 and 27...
May 2, 2018: Metabolic Syndrome and related Disorders
Gobon Sohrab, Samira Ebrahimof, Somayeh Hosseinpour-Niazi, Emad Yuzbashian, Parvin Mirmiran, Fereidoun Azizi
BACKGROUND: The purpose of the present study was to investigate the longitudinal association of total polyphenol and its main four subclasses intake with metabolic syndrome (MetS) and its components. METHODS: The present prospective study was conducted on 1265 Tehranian adults, aged 19-74 years. Usual dietary intake was evaluated using a validated food-frequency questionnaire. MetS was defined using NCEP ATP III guidelines. Intakes of total polyphenol and its four main subclasses, including flavonoids, phenolic acids, stilbenes, and lignans, were estimated using Phenol-Explorer database...
May 2, 2018: Metabolic Syndrome and related Disorders
Jaromíra Spurná, David Karásek, Veronika Kubíčková, Dominika Goldmannová, Ondřej Krystyník, Jan Schovánek, Josef Zadražil
BACKGROUND: In this study we compared levels of selected adipokines between patients with type 2 diabetes (T2D) and healthy individuals and we determined their relationship with early vascular damage markers. METHODS: Seventy-seven subjects: 56 patients with T2D (34 men and 22 women) and 21 healthy controls (8 men and 13 women) were examined in this cross-sectional study. Selected adipokines [adiponectin, adipocyte fatty acid-binding protein (A-FABP), fibroblast growth factor 21 (FGF-21), C1q/TNF-related protein 9 (CTRP-9), and allograft inflammatory factor-1 (AIF-1)] with possible cardiovascular impact were measured in all participants...
May 2, 2018: Metabolic Syndrome and related Disorders
Yun-Mi Song, Kayoung Lee
BACKGROUND: The longitudinal associations between serum uric acid (UA) levels and metabolic syndrome (MetS) and its components, as well as the shared genetic and environmental correlations between these traits, were evaluated. PARTICIPANTS AND METHODS: In a total of 1803 participants (675 men and 1128 women; 695 monozygotic twin individuals, 159 dizygotic twin individuals, and 949 non-twin family members; 44.3 ± 12.8 years old) and 321 monozygotic twin pairs with data on UA levels and MetS components at baseline and follow-up, mixed linear model, conditional logistic regression, and bivariate variance component analysis were conducted...
May 2, 2018: Metabolic Syndrome and related Disorders
Hsin-Hung Huang, Yen-Lin Chen, Jin-Shuen Chen, Jiunn-Diann Lin, Chang-Hsun Hsieh, Dee Pei, Chung-Ze Wu
AIM: Elevated levels of C-reactive protein (CRP) and alanine aminotransferase (ALT) are tightly associated with metabolic syndrome (MetS). However, it is unclear whether the combination of normal CRP and ALT increases probability of the presence of MetS. MATERIALS AND METHODS: We enrolled 433 Chinese in health screening with both CRP and ALT in normal range. They were divided into four groups: both low (BL, both low baseline CRP and ALT), only high CRP (HCRP), only high ALT (HALT), and both high (BH, both high baseline CRP and ALT) in different genders...
April 24, 2018: Metabolic Syndrome and related Disorders
Sheng-Pyng Chen, Huan-Cheng Chang, Tien-Mu Hsiao, Chih-Jung Yeh, Hao-Jan Yang
BACKGROUND: Little is known about how the frequency of physical activity in adults influences the occurrence of metabolic syndrome (MetS), and whether there are gender differences within these effects. METHODS: In this study, 3368 residents from the established "Landseed Cohort" underwent three waves of health examinations, and those who did not have MetS at baseline were selected and analyzed using a multiple Poisson regression model. By calculating the adjusted relative risk (ARR), the linear and nonlinear relationships between the frequency of physical activity and risk of developing MetS were examined for male and female participants...
April 24, 2018: Metabolic Syndrome and related Disorders
Isabelle Lemieux
No abstract text is available yet for this article.
April 19, 2018: Metabolic Syndrome and related Disorders
Lopamudra Ray, Kandasamy Ravichandran, Sunil Kumar Nanda
BACKGROUND: Metabolic syndrome (MetS), which confers a high risk for cardiovascular diseases, needs early diagnosis and treatment to reduce morbidity and mortality. Lipid accumulation product index has been reported to be an inexpensive marker of visceral fat and metabolic syndrome. This study aimed to evaluate lipid accumulation product index as a marker for metabolic syndrome in the Indian population where the prevalence of the condition is steadily increasing. METHODS: A hospital-based, case-control study was conducted with 72 diagnosed cases of metabolic syndrome and 79 control subjects...
April 12, 2018: Metabolic Syndrome and related Disorders
Parisa Amiri, Sara Jalali-Farahani, Hasti Masihay Akbar, Leila Cheraghi, Davood Khalili, Amirabbas Momenan, Parvin Mirmiran, Arash Ghanbarian, Mehdi Hedayati, Firoozeh Hosseini-Esfahani, Fereidoun Azizi
BACKGROUND: The increasing prevalence of metabolic syndrome (MetS) in childhood makes lifestyle interventions imperative during adolescence. This study aimed to assess the effects of a community-based lifestyle intervention on MetS and its components in adolescents. METHODS: Adolescents, based on their residential area were categorized into three groups: complete intervention (residing in the intervention area at baseline and during all follow-ups), incomplete intervention (residing in either the intervention or control areas and were in transition between these two areas), and control group (residing in the control area at baseline and throughout all follow-ups)...
April 12, 2018: Metabolic Syndrome and related Disorders
Kostas Archontogeorgis, Evangelia Nena, Nikolaos Papanas, Manfredi Rizzo, Athanasios Voulgaris, Maria Xanthoudaki, Maria Kouratzi, Georgia Ragia, Vangelis Manolopoulos, Athanasios Zissimopoulos, Marios Froudarakis, Paschalis Steiropoulos
BACKGROUND: Numerous studies have indicated that obstructive sleep apnea syndrome (OSAS), may contribute to the development of metabolic syndrome (MetS) and diabetes. Moreover, OSAS has been associated with lowered vitamin D (Vit D) levels, but reports are inconclusive. Aim of the study was to compare Vit D levels according to the presence of MetS and its components in OSAS patients. METHODS: The presence of MetS was evaluated and serum 25-hydroxy vitamin D [25(OH)D] levels were measured in consecutive newly diagnosed, by polysomnography, subjects with OSAS...
April 2, 2018: Metabolic Syndrome and related Disorders
Linda X Wang, Stephanie L Filipp, Elaine M Urbina, Matthew J Gurka, Mark D DeBoer
BACKGROUND: Childhood metabolic syndrome (MetS) is associated with insulin resistance and increased risk for later development of type 2 diabetes (T2DM) and cardiovascular disease (CVD). In using MetS severity z-scores, our objective was to assess longitudinal associations in MetS severity, fasting insulin levels as a sign of insulin resistance and risk for T2DM, and uric acid levels as a biomarker of oxidative stress leading to CVD. METHODS: We used linear regression to analyze longitudinal data from 285 white and black participants from the Bogalusa Heart Study evaluated at baseline at ages 5-19 and as young adults after a mean of 12...
March 27, 2018: Metabolic Syndrome and related Disorders
James R Churilla
No abstract text is available yet for this article.
March 27, 2018: Metabolic Syndrome and related Disorders
Tsuguo Nishijima, Koji Ohba, Shigeaki Baba, Testuya Kizawa, Keisuke Hosokawa, Fumiyo Endo, Yoshihiro Yamashiro, Akira Suwabe, Akira Sasaki, Kazuhiro Takahashi, Shigeru Sakurai
BACKGROUND: Plasma concentrations of soluble (pro)renin receptor [s(P)RR], which are elevated in patients with obstructive sleep apnea (OSA), have not been studied in morbid obesity. The aim of this study is to clarify effects of bariatric surgery on plasma s(P)RR concentrations and identify associated factors for their changes in OSA patients with morbid obesity. METHODS: Twenty-three patients with OSA complicated by morbid obesity (10 men and 13 women; body mass index, 40...
March 20, 2018: Metabolic Syndrome and related Disorders
Christopher E Kline, Martica H Hall, Daniel J Buysse, Conrad P Earnest, Timothy S Church
BACKGROUND: Poor sleep quality has previously been shown to be related to insulin resistance in apparently healthy adults. However, it is unclear whether an association between sleep quality and insulin resistance exists among adults with metabolic syndrome (MetS). METHODS: Participants included 347 overweight/obese postmenopausal women without type 2 diabetes (age: 57.5 ± 6.5 years; body mass index [BMI]: 31.7 ± 3.7 kg/m2 ; 54% with MetS). Sleep quality was assessed with the six-item Medical Outcomes Study Sleep Scale; values were categorized into quartiles...
March 20, 2018: Metabolic Syndrome and related Disorders
Md Jobayer Hossain, Alexa Levinson, Donald George, Jose Canas, Seema Kumar, P Babu Balagopal
BACKGROUND: The relationship among inadequate vitamin D status, obesity, and cardiometabolic risk and the potential impact of physical activity-based interventions on vitamin D status are poorly characterized in children. This study aimed to address these issues. METHODS: We studied a total of 21 adolescents (15 obese and 6 normal weight; age: 14-18 years; Tanner stage>IV). Adolescents with obesity (n = 15) underwent a randomized controlled (8 in the intervention group and 7 in the control group) 3-month physical activity-based lifestyle intervention...
March 13, 2018: Metabolic Syndrome and related Disorders
Nir Y Krakauer, Jesse C Krakauer
Body mass index (BMI) corrects body weight for height and is well established for diagnosing overweight and obesity and correlating with many medical conditions. Waist circumference (WC) is used to diagnose abdominal obesity. However, the correlation of BMI and WC is high, around 0.9, making the use of BMI and WC in concert challenging. A body shape index (ABSI) is a new measure of risk associated with abdominal size. Derived in 2012, ABSI is analogous to BMI in that it normalizes WC for weight and height (and thus to BMI)...
March 13, 2018: Metabolic Syndrome and related Disorders
Sayaka Kadowaki, Katsuyuki Miura, Takashi Kadowaki, Akira Fujiyoshi, Aiman El-Saed, Kamal H Masaki, Tomonori Okamura, Daniel Edmundowicz, Beatriz L Rodriguez, Yasuyuki Nakamura, Emma J M Barinas-Mitchell, Aya Kadota, Bradley J Willcox, Robert D Abbott, Lewis H Kuller, Jina Choo, Chol Shin, Hirotsugu Ueshima, Akira Sekikawa
BACKGROUND: Abdominal fat distribution varies across groups with different races or environments. Whether environmental factors, apart from racial differences, affect abdominal fat distribution is unknown. METHODS: We compared the abdominal fat distribution of four groups; different races with similar environments (Caucasians vs. Japanese Americans), different environments with an identical race (Japanese Americans vs. Japanese), and similar races with similar environments (Japanese vs...
May 2018: Metabolic Syndrome and related Disorders
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