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Metabolic Syndrome and related Disorders

Azam Soleimani, Ali Pourmoghaddas, Masoumeh Sadeghi, Hamidreza Roohafza, Mohammad Talaei, Minoo Dianatkhah, Shahram Oveisgharan, Maryam Soleimani, Nizal Sarrafzadegan
BACKGROUND: There is still a controversy about the causal relationship between menopause status and cardiovascular disease (CVD). The present study aimed to evaluate whether premature menopause would predict higher risk and lower the age of CVD occurrence and how this differs in women with metabolic syndrome (MetS). METHODS: Using a population-based Isfahan Cohort Study (ICS), 1154 postmenopause women were followed up from 2001 to 2013 for any CVD occurrence. Cox proportional hazards regression analyses were used to estimate the association between menopause age of (≤45, 46-50, 51-55, ≥56 years) and CVD incidence...
February 13, 2018: Metabolic Syndrome and related Disorders
Vasu D Gooty, Alan R Sinaiko, Justin R Ryder, Donald R Dengel, David R Jacobs, Julia Steinberger
BACKGROUND: Measures of carotid intima media thickness (cIMT) in adults are correlated with adiposity and the metabolic syndrome (MetS) and predict cardiovascular (CV) events. Relations in children are not as well studied. Our objective was to determine the relations of cIMT with body mass index (BMI) and CV risk score in children. METHODS: The study included 291 children (158 M/133 F) 6-18 years of age (140 aged 6-11/151 aged 12-18) with measurements of height, weight, waist circumference; fasting lipids, glucose, insulin, and cIMT...
February 7, 2018: Metabolic Syndrome and related Disorders
Lei Lynn, Dana Kay, Naji Younes, Sabyasachi Sen, Vivek Jain
BACKGROUND: Diabetes Mellitus is one of the most common chronic diseases in the United States and worldwide. In 2009 the American Diabetes Association (ADA) recommended using A1C greater than 6.5% to diagnose diabetes. Hemoglobin A1C can be measured by laboratory and Point-of-Care (POC) methods. It is important to compare results obtained by the two modalities to determine the proper use of these tests. METHODS: One hundred fifteen patients were identified to have both POC and laboratory A1C values obtained on the same day, between August 2013 and August 2014...
February 6, 2018: Metabolic Syndrome and related Disorders
Neila Hiraishi Mallmann, Emerson Silva Lima, Pritesh Lalwani
OBJECTIVE: Obesity and metabolic syndrome are preventable complex-multifactorial disorders that severely increase risk of cardiovascular disease (CVD). Indoleamine 2,3-dioxygenase (IDO) enzyme converts tryptophan (TRP) to kynurenine (KYN); besides, KYN/TRP ratio has been shown to predict major coronary events and all-cause mortality in patients with coronary artery disease. However, their role in metabolic syndrome is not understood. METHODS: In a cross-sectional study (n = 161, mean population age in years = 32 ± 7...
February 6, 2018: Metabolic Syndrome and related Disorders
Rocío Ramírez-Jiménez, María Fernanda Martínez-Salazar, Damianys Almenares-López, Leticia Yáñez-Estrada, Antonio Monroy-Noyola
BACKGROUND: The enzymes butyrylcholinesterase (BuChE) and paraoxonase-1 (PON1) are the primary bioscavenging enzymes in serum and exhibit antioxidant and anti-inflammatory activities. PON1 has been associated with diseases caused by high oxidative stress, whereas BuChE appears to be involved in the pathophysiology of the metabolic syndrome and related disorders. It has been suggested that children from rural communities in Mexico may have a predisposition to develop obesity or type 2 diabetes during adolescence or adulthood...
February 2, 2018: Metabolic Syndrome and related Disorders
Michael R Richardson, Andrea Y Arikawa, James R Churilla
BACKGROUND: Some evidence suggests an inverse association between increased fiber intake and C-reactive protein (CRP). However, few studies have examined the associations among CRP, dietary fiber, and leisure-time physical activity (LTPA) in a nationally representative sample of U.S. adults. METHODS: Sample (n = 8372) included adults (≥20 years of age) who participated in the 2007-2010 National Health and Nutrition Examination Survey. Tertiles of reported fiber intake were created...
January 29, 2018: Metabolic Syndrome and related Disorders
Casey L Peiris, Nicholas F Taylor, Susan Hull, Amanda Anderson, Regina Belski, Spiros Fourlanos, Nora Shields
BACKGROUND: One quarter of the world's adults have metabolic syndrome. Lifestyle modification is the first line of intervention as improvements in diet and exercise can have positive effects on the individual components of metabolic syndrome. The primary aim of this research was to evaluate the effect of an 8-week lifestyle intervention program for people with metabolic syndrome on emergency department presentations, hospital admissions, and metabolic parameters. METHODS: A retrospective case-control study of adults (n = 58, mean age 60 ± 7 years) with metabolic syndrome referred to a group lifestyle self-management intervention program between 2013 and 2015...
January 23, 2018: Metabolic Syndrome and related Disorders
Elizabeth Ma, Yuchang Fu, W Timothy Garvey
BACKGROUND: Insulin resistance disrupts metabolic processes and leads to various chronic disease states such as diabetes and metabolic syndrome (MetS). However, the mechanism linking insulin resistance with cardiometabolic disease pathophysiology is still unclear. One possibility may be through circulating microRNAs (c-miRs), which can alter gene expression in target tissues. Our goal was to assess the relationship of c-miRs with insulin sensitivity, as measured by the gold standard, hyperinsulinemic-euglycemic clamp technique...
January 23, 2018: Metabolic Syndrome and related Disorders
Mingzhen Li, Daiqing Li, Yunzhao Tang, Lingling Meng, Cuixiu Mao, Lirong Sun, Baocheng Chang, Liming Chen
BACKGROUND: Our prior study showed that patients with sleep disorders had poor blood pressure (BP), glycemic control, and more severe complications. Therefore, sleep is very important for diabetic control. Our work was to investigate whether individualized diabetes sleep education significantly improve sleep quality and glycemic control in type 2 diabetic patients who sleep after midnight and potential mechanism by a randomized parallel interventional study. METHODS: T2D patients were randomly recruited to an intervention or control group...
January 22, 2018: Metabolic Syndrome and related Disorders
Rasmus Baadsgaard Mærkedahl, Hanne Frøkiær, Marie Grøntved Stenbæk, Camilla Betak Nielsen, Mads V Lind, Christian Lundtoft, Marietta Boje Bohr, Sabine Ibrügger, Stine Broeng Metzdorff, Henrik Vestergaard, Oluf Pedersen, Lotte Lauritzen
BACKGROUND: Low-grade systemic inflammation (LGSI) is often characterized by elevated levels of interleukin (IL)6, tumor necrosis factor (TNF)α, and C-reactive protein (CRP). Other serum proteins, ex vivo-stimulated cytokine production, and leukocyte count have, however, also been suggested LGSI-markers, but their associations with the metabolic syndrome (MS) are less clear. We aimed to evaluate mutual relationships between in vivo and ex vivo inflammatory markers and their association with MS and its subcomponents...
January 10, 2018: Metabolic Syndrome and related Disorders
Muammer Buyukinan, Muge Atar, Ummugulsum Can, Ozgur Pirgon, Asuman Guzelant, Isa Deniz
BACKGROUND AND AIM: Excess visceral fat accumulation results in altered release of adipokines. The aim of this study was to examine the relationship between new adipokines (omentin-1 and vaspin), insulin resistance, and serum inflammatory markers in obese subjects with metabolic syndrome (MS). PATIENTS AND METHODS: The study included a total of 121 obese children (79 females and 42 males, aged 12-17 years old). The obese subjects were divided into two groups based on the presence or absence of MS criteria (MS group and non-MS group)...
January 10, 2018: Metabolic Syndrome and related Disorders
Samira Ebrahimof, Firoozeh Hosseini-Esfahani, Parvin Mirmiran, Mojtaba Fallah-Kezabi, Fereidoun Azizi
BACKGROUND: Healthy dietary habits can prevent cardiovascular diseases (CVD). The aim of this study was to investigate the association between dietary patterns and predicted risk of CVD development using Framingham Risk Score (FRS) in Iranian population over 6 years of follow-up. METHODS: In this prospective study, 2333 individuals aged 30-74 years with a 10-year predicted risk <10% and without a CVD diagnosis at baseline were recruited from participants in the third survey of Tehran Lipid and Glucose Study...
January 2, 2018: Metabolic Syndrome and related Disorders
Seema Kumar, P Babu Balagopal
No abstract text is available yet for this article.
March 2018: Metabolic Syndrome and related Disorders
Bethany D Williams, Susan B Sisson, Chris A Ardern, Katrina D DuBose, Tammie M Johnson, M Ryan Richardson, James R Churilla
BACKGROUND: While studies to date have shown that children and adolescents who meet the current physical activity (PA) recommendations and maintain a healthy body weight demonstrate significantly lower cardiometabolic risk, there are some studies that suggest that the relationship between PA and metabolic risk may be mediated by adiposity. The aim of the present study was to examine variation in clustered metabolic risk (cMetS) in adolescents classified as not overweight/active (NOA), not overweight/not active (NONA), overweight/active (OA), and overweight/not active (ONA)...
March 2018: Metabolic Syndrome and related Disorders
Bharat Bhushan
No abstract text is available yet for this article.
February 2018: Metabolic Syndrome and related Disorders
Renée de Mutsert, Karin Gast, Ralph Widya, Eelco de Koning, Ingrid Jazet, Hildo Lamb, Saskia le Cessie, Albert de Roos, Jan Smit, Frits Rosendaal, Martin den Heijer
BACKGROUND: Abdominal obesity is a well-established risk factor for the development of type 2 diabetes. However, sex differences may exist. We aimed to investigate the associations of abdominal subcutaneous adipose tissue (SAT) and visceral adipose tissue (VAT) with insulin resistance and insulin secretion in men and women. METHODS: In this cross-sectional analysis of the Netherlands Epidemiology of Obesity study, fasting and postprandial concentrations of glucose and insulin were measured and abdominal fat depots were assessed using magnetic resonance imaging in 2253 participants (53% women)...
February 2018: Metabolic Syndrome and related Disorders
Hyun-Jung Lee, Hack-Lyoung Kim, Jaehoon Chung, Woo-Hyun Lim, Jae-Bin Seo, Sang-Hyun Kim, Joo-Hee Zo, Myung-A Kim
BACKGROUND: Metabolically healthy obese (MHO) individuals generally show better cardiovascular prognosis compared with metabolically unhealthy counterparts, which may be related to different patterns of target organ damage (TOD). We aimed to investigate the patterns of TOD related to obesity and metabolic unhealthiness. METHODS: A total of 659 Korean adults (mean age, 60.0 ± 11.8 years; male, 51.1%) undergoing health examinations were stratified into four groups according to obesity (body mass index ≥25...
February 2018: Metabolic Syndrome and related Disorders
Rodrigo P Pedrosa, Cristiane Maki-Nunes, Thiago Midlej-Brito, Heno F Lopes, Lunara S Freitas, Ivani C Trombetta, Edgar Toschi-Dias, Maria Janieire N N Alves, Raffael F Fraga, Maria U Rondon, Carlos E Negrão, Luiz A Bortolotto, Geraldo Lorenzi-Filho, Luciano F Drager
BACKGROUND: Recent evidence suggests that obstructive sleep apnea (OSA) is common in patients with metabolic syndrome (MetS) and may contribute to metabolic deregulation, inflammation, and atherosclerosis in these patients. In clinical practice, however, OSA is frequently underdiagnosed. We sought to investigate the clinical predictors of OSA in patients with MetS. METHODS: We studied consecutive patients newly diagnosed with MetS (Adult Treatment Panel-III). All participants underwent clinical evaluation, standard polysomnography, and laboratory measurements...
February 2018: Metabolic Syndrome and related Disorders
Natalie Podolski, Klara Brixius, Hans G Predel, Christian Brinkmann
BACKGROUND: Cognitive decline has been shown to be associated with long-term type 2 diabetes mellitus (T2DM). This review analyzes the present literature to ascertain the role of regular physical activity (PA) for the functioning of the diabetic brain. METHODS: PubMed was systematically searched for relevant publications up to July 2017. RESULTS: Four cross-sectional, one longitudinal observational, and nine interventional studies with a total of ∼7000 T2DM subjects are included in this review...
December 2017: Metabolic Syndrome and related Disorders
Nomandla Daphne Madala, Thozama Dubula, Alain Guy Honoré Assounga, Saraladevi Naicker
BACKGROUND: Recent evidence that hyperuricemia is associated with incident chronic kidney disease (CKD) provides a potential therapeutic target for CKD that has not been explored in Africans. With hyperuricemia and gout increasing globally, we sought to determine their prevalence in South Africans with varying kidney function levels. METHODS: This was a cross-sectional study of ambulatory adult patients presenting at a General Internal Medicine Outpatients Clinic between September 2012 and March 2014...
December 2017: Metabolic Syndrome and related Disorders
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