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Metabolic Syndrome and related Disorders

Eytan Cohen, Ili Margalit, Elad Goldberg, Ilan Krause
BACKGROUND: Overweight and obesity are more common in men than in women. This explains the higher prevalence of risk factors for metabolic syndrome (MetS) found in men. We aimed to assess whether gender, per se, might be an independent risk factor for the components of MetS in a large cohort of subjects within the normal range of body mass index (BMI). MATERIALS AND METHODS: Cross-sectional analysis was carried out on 9976 men and women, aged 18 to 70 years, with a BMI between 18...
September 11, 2018: Metabolic Syndrome and related Disorders
Hyun Joo Lee, Hyun Nyung Jo, Yun Hwa Kim, Seung Chul Kim, Jong Kil Joo, Kyu Sup Lee
BACKGROUND: The aim of this study is to investigate the value of clinical indicators of metabolic syndrome according to menopausal status in healthy Korean women. METHODS: The study included 3936 female patients who were managed at Pusan National University Hospital Health Promotion Center from 2008 to 2014. Each patient completed self-report questionnaires and underwent personal interviews with a healthcare provider to assess their past medical history such as any previous disease, medication and/or menstrual histories along with the measurement of her current body size...
September 5, 2018: Metabolic Syndrome and related Disorders
Angela Cozma, Adela Sitar-Taut, Olga Orăşan, Daniel Leucuta, Teodora Alexescu, Adina Stan, Vasile Negrean, Dorel Sampelean, Dana Pop, Dumitru Zdrenghea, Romana Vulturar, Adriana Fodor
BACKGROUND: Metabolic syndrome (MS) is a clustering entity characterized by obesity, hypertension, hyperglycemia, dyslipidemia, and insulin resistance. Early detection of atherosclerosis is important in patients with MS because cardiovascular diseases are the main cause of mortality in these patients. METHODS: We aimed to investigate the factors influencing arterial stiffness, pulse wave velocity, and the augmentation index, respectively, in 150 subjects with MS (94 women and 56 men; mean age 60...
September 5, 2018: Metabolic Syndrome and related Disorders
Lars Lind, Erik Ingelsson, Johan Ärnlöv, Johan Sundström, Björn Zethelius, Gerald M Reaven
BACKGROUND: The plasma concentration ratio of triglyceride (TG)/high-density lipoprotein cholesterol (HDL-C) is a simple way to estimate insulin resistance. We aimed to evaluate the TG/HDL-C ratio as a simple clinical way to identify apparently healthy individuals with insulin resistance and enhanced risk of future cardiovascular disease (CVD). METHODS: One thousand seven hundred twenty men, aged 50 years, free from diabetes and CVD when evaluated at baseline in 1970-1974 were followed for 40 years regarding incident CVD (myocardial infarction and/or ischemic stroke, n = 576)...
September 5, 2018: Metabolic Syndrome and related Disorders
Şahbender Koç, Selçuk Baysal, Zuhal Koç, Arif Ülkü Yener
BACKGROUND: Glycated hemoglobin (HbA1c) is an index of the average blood glucose level over the preceding 2-3 months. In experimental studies, the lens responded to changes in osmolarity by forming vacuoles. By observing the vacuoles of the lens during eye examination, can we detect changes in osmolarity and glycemia over the last 6 months through HbA1c levels? METHODS: In total, 400 patients (mean age, 67.7 ± 9.8 years), including those with diabetes mellitus, hypertension, and heart failure, were included in the study...
September 5, 2018: Metabolic Syndrome and related Disorders
Maciej Haberka, Katarzyna Stolarz-Skrzypek, Małgorzata Biedroń, Karolina Szóstak-Janiak, Małgorzata Partyka, Magdalena Olszanecka-Glinianowicz, Zbigniew Gąsior
BACKGROUND: Hypertension and obesity are very common and complex cardiovascular (CV) risk factors. Our aim was to provide a comprehensive assessment of associations between visceral fat depots and vascular or cardiac complications of hypertension. METHODS: All the consecutive patients (age: 45-80 years old) scheduled for elective coronary angiography in the Department of Cardiology were screened, and 400 patients were included into the study group. All the patients had a comprehensive clinical assessment focused on hypertension and obesity, risk factors, fat depots, and several hypertension-related vascular or cardiac complications...
September 5, 2018: Metabolic Syndrome and related Disorders
Andrea Santi, Tyler A Bosch, Anne E Bantle, Alison Alvear, Qi Wang, James S Hodges, Donald R Dengel, Lisa S Chow
BACKGROUND: Despite the benefits of aerobic exercise on body composition, runners with high body mass index (BMI) remain understudied. We examined body composition differences between sedentary insulin-resistant [obese insulin-resistant sedentary (OS-IR)], sedentary insulin-sensitive [obese insulin-sensitive sedentary (OS-IS)], and trained [obese trained (OT)] individuals with high BMI (≥25 kg/m2 ). We hypothesized that after matching for high BMI, OT individuals would have less fat mass (absolute and relative) and greater lean mass than OS-IR or OS-IS individuals...
August 21, 2018: Metabolic Syndrome and related Disorders
Kayoung Lee
BACKGROUND: The association of handgrip strength with nonalcoholic fatty liver disease (NAFLD) has not been studied yet. This study investigated the relationship between handgrip strength and NAFLD in South Korean adults. METHODS: Referring to the Korea National Health and Nutrition Examination Survey 2014 and 2015 database, South Korean adults (n = 8001, women: 55.5%) aged 19-80 years having complete data were considered for this study. Relative handgrip strength (RHGS) [average handgrip strength of both hands divided by body mass index (BMI)], hepatic steatosis index (HSI), BMI, and components of metabolic syndrome were measured...
August 21, 2018: Metabolic Syndrome and related Disorders
Courtney L Millar, Quinn Duclos, Chelsea Garcia, Gregory H Norris, Bruno S Lemos, Diana M DiMarco, Maria Luz Fernandez, Christopher N Blesso
BACKGROUND: High-density lipoprotein (HDL) particles are protective against atherosclerosis. However, HDL function is impaired in metabolic syndrome (MetS) due to low-grade inflammation and dyslipidemia. Foods containing polyphenols, such as grapes, may prevent HDL dysfunction via antioxidant or anti-inflammatory effects. We evaluated the effects of grape powder ingestion on measures of HDL function in adults with MetS. METHODS: Twenty adults (age: 32-70 years; body mass index: 25...
August 21, 2018: Metabolic Syndrome and related Disorders
Hartmut Ruetten, Mathias Gebauer, Ralph H Raymond, Roberto A Calle, Claudio Cobelli, Atalanta Ghosh, R Paul Robertson, Sudha S Shankar, Myrlene A Staten, Darko Stefanovski, Adrian Vella, Kathryn Wright, David A Fryburg
BACKGROUND: The aims of this study were to 1. define the responses of glucagon-like peptide-1 (GLP-1), glucose-dependent insulinotropic polypeptide (GIP), glucagon, and peptide YY (PYY) to an oral meal and to intravenous L-arginine; and 2. examine correlation of enteroendocrine hormones with insulin secretion. We hypothesized a relationship between circulating incretin concentrations and insulin secretion. METHODS: Subjects with normal glucose tolerance (NGT, n = 23), prediabetes (PDM, n = 17), or with type 2 diabetes (T2DM, n = 22) were studied twice, following a mixed test meal (470 kCal) (mixed meal tolerance test [MMTT]) or intravenous L-arginine (arginine maximal stimulation test [AST], 5 g)...
August 17, 2018: Metabolic Syndrome and related Disorders
Phalakorn Suebsamran, Taksin Pimpak, Patnapa Thani, Parinya Chamnan
BACKGROUND: Although metabolic syndrome (MetS) has become a significant public health problem worldwide, little evidence exists to describe the prevalence of MetS in school children using MetS different classifications, and its association with health-related behaviors. METHODS: Using data on 393 children and adolescents aged 13-16 years participating in the Ubon Ratchathani Metabolic Syndrome in Adolescent (UMeSIA) Project, the prevalence of MetS was determined using the International Diabetes Federation (IDF) 2007 definition and other three classifications reported in the previous literature...
August 14, 2018: Metabolic Syndrome and related Disorders
Jae-Min Park, Ji-Won Lee, Jae-Yong Shim, Yong-Jae Lee
BACKGROUND: To examine the relationship between platelet count and insulin resistance, as measured by a homeostasis model assessment of insulin resistance (HOMA-IR), in a nationally representative sample of Korean adolescents. METHODS: The study population comprised 1133 participants (636 male and 497 female participants) aged 12-18 years selected from the 2008-2010 Korea National Health and Nutrition Examination Survey. Insulin resistance was defined as a HOMA-IR value greater than the 85th percentile...
August 10, 2018: Metabolic Syndrome and related Disorders
Mohammed Azab, Abdel-Ellah Al-Shudifat, Asgeir Johannessen, Amjad Al-Shdaifat, Lana M Agraib, Reema F Tayyem
BACKGROUND: Although obesity is an independent risk factor for coronary artery disease (CAD), observational studies have found that persons with obesity have a better prognosis in established CAD compared with those with a normal body weight, suggesting that the underlying risk factors might differ between the two groups. In this study, we studied risk factors for CAD in persons with and without obesity in a Middle Eastern setting where obesity is endemic. METHODS: Five hundred and fifty-six patients referred for elective coronary catheterization at Prince Hamza Hospital, Amman were included in a cross-sectional study...
August 8, 2018: Metabolic Syndrome and related Disorders
Ana Ligia Gutiérrez-Solis, Sudip Datta Banik, Rosa María Méndez-González
BACKGROUND: Metabolic syndrome (MetS) is closely linked with type 2 diabetes mellitus (T2DM) and cardiovascular diseases. The T2DM is one of the major causes of mortality and public health concern in Mexico. Some studies reported MetS prevalence in different regions from Mexico. However, a systematic report or meta-analysis on MetS prevalence is not available. The aim of this study was to estimate the pooled prevalence of MetS among apparently healthy Mexican adults. METHODS: A systematic review was done of scientific articles published and available from different sources, including MEDLINE/PubMed, Web of Science, Cochrane Library, LILACS, and SCIELO...
July 31, 2018: Metabolic Syndrome and related Disorders
Michael Camilleri, Andres Acosta
The objective of this review is to examine advances in the development of combination therapies for the treatment of obesity beyond diet or lifestyle interventions. Experimental combination pharmacotherapies include combinations of pramlintide and phentermine as well as amylin and bupropion-naltrexone. Incretin and pancreatic hormones generally inhibit upper gastrointestinal motor functions, and combinations showing efficacy in obesity are coadministration of glucagon-like peptide-1 (GLP-1) with glucagon, a unimolecular dual incretin of PEGylated GLP-1/GIP coagonist, the combination of GLP-1 and PYY3-36 , and, in proof of concept studies, combined infusions of GLP-1, peptide YY, and oxyntomodulin...
July 11, 2018: Metabolic Syndrome and related Disorders
J D Adams, Adrian Vella
Type 2 diabetes mellitus (T2DM) is a polygenic metabolic disorder characterized by hyperglycemia occurring as a result of impaired insulin secretion and/or insulin resistance. Among the various genetic factors associated with T2DM, a common genetic variant within the transcription factor 7-like 2 locus (TCF7L2) confers the greatest genetic risk for development of the disease. However, the mechanism(s) by which TCF7L2 predisposes to diabetes remain uncertain. Here we review the current literature pertaining to the potential mechanisms by which TCF7L2 confers risk of T2DM, using genetic variation as a probe to understand the pathogenesis of the disease...
July 11, 2018: Metabolic Syndrome and related Disorders
Insub Kim, Yun-Mi Song, Hyeonyoung Ko, Joohon Sung, Kayoung Lee, Jinyoung Shin, Sujeong Shin
BACKGROUND: The objective of this study was to evaluate the relationship between educational level as a surrogate marker of socioeconomic status and the risk of developing metabolic syndrome (MetS). METHODS: Study subjects were 1915 Korean adults (1193 women and 722 men) who participated in a cohort study. Educational level was categorized into two groups: (1) high education (more than 12 years of education), and (2) low education (less than 12 years of education)...
July 5, 2018: Metabolic Syndrome and related Disorders
Golbon Sohrab, Javad Nasrollahzadeh, Maryam Tohidi, Hamid Zand, Omid Nikpayam
BACKGROUND: Few studies have examined anti-inflammatory effects of pomegranate juice (PJ). The present study aimed to evaluate the effect of PJ on nuclear factor kappa B (NF-κB) p65 and sirtuin1 in peripheral blood mononuclear cell (PBMC), and plasma vascular inflammation biomarkers. METHODS: Patients with type 2 diabetes were randomly assigned to either the PJ (n = 22) or the placebo group (n = 22). The patients in the PJ group received 250 mL of PJ daily for 12 weeks, whereas the placebo group received corresponding control beverages of similar color and energy content...
June 29, 2018: Metabolic Syndrome and related Disorders
Füsun Erdenen, Hülya Güngel, Esma Altunoğlu, Duygu Şak, Cüneyt Müderrisoğlu, Atakan Koro, Pınar Akça Güler, Muzaffer Ece Hakan Sahin, Gonul Simsek, Hafize Uzun
BACKGROUND: Diabetic retinopathy (DR) is mainly caused by metabolic factors, vascular inflammation, and endothelial dysfunction. We aimed to evaluate the relationship of DR with inflammatory and biochemical alterations in type 2 diabetics. METHODS: A total of 89 diabetic patients with retinopathy [(DR (+) (n = 30)], without retinopathy [(DR (-) (n = 32)], and 27 control subjects were involved in the study. Demographic properties, biochemical values, ophtalmologic evaluation, C-reactive protein (CRP), and pentraxin-3 (PTX-3) levels were recorded...
September 2018: Metabolic Syndrome and related Disorders
Kameliya Bratoeva, Silviya Nikolova, Albena Merdzhanova, George St Stoyanov, Eleonora Dimitrova, Javor Kashlov, Nikolay Conev, Mariya Radanova
BACKGROUND: The pathogenesis of nonalcoholic fatty liver disease as a component of metabolic syndrome (MetS) involves the activation of apoptosis in steatotic hepatocytes. Caspase-generated fragments such as cytokeratin-18 (CK-18) in patients with various hepatic impairments are investigated as markers for diagnosis and assessment of disease severity. The goal of the study was to capture early biomarkers of apoptosis and elucidate their role in assessing the presence and extent of hepatic damage in a MetS model...
September 2018: Metabolic Syndrome and related Disorders
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