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Metabolic Syndrome and related Disorders

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https://www.readbyqxmd.com/read/28759349/association-between-handgrip-muscle-strength-and-cardiometabolic-z-score-in-children-6-to-19-years-of-age-results-from-the-canadian-health-measures-survey
#1
Brittany V Rioux, Paul Kuwornu, Atul Sharma, Mark S Tremblay, Jonathan M McGavock, Martin Sénéchal
BACKGROUND: It is unclear if muscle strength, another index of fitness, which confers the protection from cardiometabolic risk in adults, is associated with similar protection in children and youth. The purpose of this study was to investigate the association between handgrip strength and cardiometabolic health in a large Canadian sample of children and youth. METHODS: We performed a cross-sectional analysis of the Canadian sample of children and youth aged 6 to 19 years (n = 1376) studied in the Canadian Health Measures Survey (cycles 1 and 2) between 2007 and 2011...
July 31, 2017: Metabolic Syndrome and related Disorders
https://www.readbyqxmd.com/read/28749722/association-between-plasma-proprotein-convertase-subtilisin-kexin-type-9-and-the-presence-of-metabolic-syndrome-in-a-predominantly-rural-based-sub-saharan-african-population
#2
Martine Paquette, Yascara Grisel Luna Saavedra, Ann Chamberland, Annik Prat, Dirk Lund Christensen, Fannie Lajeunesse-Trempe, Lydia Kaduka, Nabil G Seidah, Robert Dufour, Alexis Baass
BACKGROUND: The prevalence of metabolic syndrome (MetS) has increased dramatically in low- and middle-income countries. Proprotein convertase subtilisin/kexin type 9 (PCSK9) plays a major role in low-density lipoprotein receptor degradation, but its relationship with metabolic parameters is still poorly understood. We aimed to investigate the association between plasma PCSK9 and metabolic parameters in a Kenyan cohort. METHODS: Total plasma PCSK9 levels were measured in 2016 by an in-house enzyme-linked immunosorbent assay using a polyclonal antibody...
July 27, 2017: Metabolic Syndrome and related Disorders
https://www.readbyqxmd.com/read/28737448/mast-cell-and-m1-macrophage-infiltration-and-local-pro-inflammatory-factors-were-attenuated-with-incretin-based-therapies-in-obesity-related-glomerulopathy
#3
Jiao He, Geheng Yuan, Fangxiao Cheng, Junqing Zhang, Xiaohui Guo
BACKGROUND: The global increase of obesity parallels the obesity-related glomerulopathy (ORG) epidemic. Dipeptidyl peptidase 4 inhibitors and glucagon-like peptide-1 receptor agonists were well recognized to attenuate renal injury independent of glucose control in diabetic nephropathy. There are limited studies focusing on their effects on ORG. We explored the effects of incretin-based therapies on early ORG and the inflammatory responses involved mainly concentrated on mast cell (MC) and macrophage (M) infiltration and local pro-inflammatory factors...
July 24, 2017: Metabolic Syndrome and related Disorders
https://www.readbyqxmd.com/read/28727953/fatty-acid-composition-of-plasma-phosphatidylcholine-determines-body-fat-parameters-in-subjects-with-metabolic-syndrome-related-traits
#4
Miroslav Zeman, Marek Vecka, Michal Burda, Eva Tvrzická, Barbora Staňková, Jaroslav Macášek, Aleš Žák
BACKGROUND: This study examines the associations of fatty acids (FAs) in plasma phosphatidylcholine (PC) with the anthropometrical and biochemical characteristic of patients with metabolic syndrome (MetS)-related traits. METHODS: We analyzed the FA profiles of PC in 300 persons with MetS-related traits (152 M/148F, mean age 46.9 ± 9.0 years) and in 70 healthy controls of the same age using a balanced men/women ratio and gas-liquid chromatography. Multivariate linear regression analysis was performed to determine the coefficients of determination (R(2)) using FA proportions of the mentioned proband characteristics...
July 20, 2017: Metabolic Syndrome and related Disorders
https://www.readbyqxmd.com/read/28727943/the-genetic-background-of-metabolic-trait-clusters-in-children-and-adolescents
#5
Karri Silventoinen, Élvio Gouveia, Aline Jelenkovic, José Maia, António M Antunes, Miguel A A Pinheiro de Carvalho, António M Brehm, Martine Thomis, Johan Lefevre, Jaakko Kaprio, Duarte Freitas
BACKGROUND: It is well known that metabolic risk factors of cardiovascular diseases are correlated, but the background of this clustering in children is more poorly known than in adults. Thus, we studied the contribution of genetic and environmental factors to the clustering of metabolic traits in childhood and adolescence. DATA AND METHODS: Nine metabolic traits were measured in 214 complete twin pairs aged 3-18 years in the Autonomous Region of Madeira, Portugal, in 2007 and 2008...
July 20, 2017: Metabolic Syndrome and related Disorders
https://www.readbyqxmd.com/read/28677982/determinants-of-incident-metabolic-syndrome-in-a-middle-eastern-population-isfahan-cohort-study
#6
Naeimeh Hosseini, Mohammad Talaei, Minoo Dianatkhah, Masoumeh Sadeghi, Shahram Oveisgharan, Nizal Sarrafzadegan
BACKGROUND: To identify the associated risk factors with development of metabolic syndrome (MetS) in a longitudinal prospective cohort study in an Iranian population. METHODS: A total of 1994 participants, aged ≥35 years, free of MetS, diabetes, and cardiovascular disease at baseline were followed up for 7 years. Physical examination, laboratory studies, and interview about lifestyle factors were performed, and MetS was defined based on harmonized definition at both time points...
July 5, 2017: Metabolic Syndrome and related Disorders
https://www.readbyqxmd.com/read/28657427/expression-of-metabolic-syndrome-in-women-with-severe-obesity
#7
James L Hopkins, Paul N Hopkins, Eliot A Brinton, Ted D Adams, Lance E Davidson, M Nazeem Nanjee, Steven C Hunt
BACKGROUND: The prevalence of metabolic syndrome (MetS) generally rises with increasing adiposity, but tends to plateau at the highest levels of body mass index (BMI) with some individuals, even with severe obesity, expressing few or no components of MetS. We examined factors associated with the expression of MetS in severely obese women participating in a large observational study. METHODS: Anthropometrics, including Heath equation-adjusted bioimpedance-determined fat-free mass (FFM) and fat mass (FM), lipids and related laboratory measurements, resting energy expenditure (REE), and respiratory quotient (RQ), were studied in 949 women with severe obesity...
June 28, 2017: Metabolic Syndrome and related Disorders
https://www.readbyqxmd.com/read/28605281/re-plasminogen-activator-inhibitor-1-and-pericardial-fat-in-individuals-with-type-2-diabetes-mellitus-by-bayomi-et-al-metab-syndr-relat-disord-doi-10-1089-met-2017-0031
#8
Angelo Avogaro
Plasminogen activator inhibitor-1 (PAI-1) is a member of the serine protease inhibitor (serpin) superfamily, which inactivates tissue plasminogen activator (tPA); therefore, increased level of PAI-1 antigen counteracts the anticoagulant effect of tPA and facilitates the fibrin clot formation. Plasma PAI-1 antigen and activity levels are associated with increased body mass index and with features of the insulin resistance syndrome like obesity and diabetes. Visceral adipose tissue produces more PAI-1 than subcutaneous adipose tissue: This increased production of PAI-1 from the visceral adipose tissue is one important link between visceral obesity and cardiovascular disease...
June 12, 2017: Metabolic Syndrome and related Disorders
https://www.readbyqxmd.com/read/28586263/the-interplay-between-fat-mass-and-fat-distribution-as-determinants-of-the-metabolic-syndrome-is-sex-dependent
#9
Lars Lind, Johan Ärnlöv, Erik Lampa
BACKGROUND: Fat mass and fat distribution are major determinants of the metabolic syndrome (MetS), but the interplay between them has not been thoroughly investigated. In addition, fat mass and fat distribution are generally different in men than in women. We aimed to determine whether the interplay between fat mass and fat distribution regarding MetS and its components is sex-dependent using data from the large-scale population-based sample EpiHealth. METHODS: Occurrence of MetS and its components was determined together with fat mass by bioimpedance in 19,094 participants in the EpiHealth sample [mean age 61 years (SD 8...
June 6, 2017: Metabolic Syndrome and related Disorders
https://www.readbyqxmd.com/read/28570830/comparison-of-three-adiposity-indexes-and-cutoff-values-to-predict-metabolic-syndrome-among-university-students
#10
Jorge Enrique Correa-Bautista, Katherine González-Ruíz, Andrés Vivas, Héctor Reynaldo Triana-Reina, Javier Martínez-Torres, Daniel Humberto Prieto-Benavides, Hugo Alejandro Carrillo, Jeison Alexander Ramos-Sepúlveda, María Isabel Afanador-Rodríguez, Emilio Villa-González, Antonio García-Hermoso, Robinson Ramírez-Vélez
PURPOSE: Obesity and high body fat are related to diabetes and metabolic syndrome (MetS) in all ethnic groups. Based on the International Diabetes Federation (IDF) definition of MetS, the aim of the present study was to compare body adiposity indexes (BAIs) and to assess their various cutoff values for the prediction of MetS in university students from Colombia. METHODS: A cross-sectional study was conducted on 886 volunteers (51.9% woman; age mean 21.4 years). Anthropometric characteristics (height, weight, waist circumference [WC], and hip circumference [HC]) were measured, and body composition was assessed by bioelectrical impedance analysis...
June 1, 2017: Metabolic Syndrome and related Disorders
https://www.readbyqxmd.com/read/28605280/the-gut-a-key-to-the-pathogenesis-of-type-2-diabetes
#11
Jens Juul Holst, Jens Pedersen, Nicolai Jacob Wewer Albrechtsen, Filip Krag Knop
In this communication we discuss the role of the gut for the development of type 2 diabetes mellitus (T2DM). Gastric emptying rates importantly determine postprandial glucose excursions and regulate postprandial secretion of the incretin hormones, glucose-dependent insulinotropic polypeptide (GIP), and glucagon-like peptide-1 (GLP-1). It thereby also determines their powerful, amplifying effect on glucose-induced insulin secretion and thus the ability of the body to regulate glucose disposal. Although disturbances in gastric emptying are not consistent findings in type 2 diabetes, the incretin system is seriously impaired, probably associated with insulin resistance and obesity...
August 2017: Metabolic Syndrome and related Disorders
https://www.readbyqxmd.com/read/28394194/the-higher-the-insulin-resistance-the-lower-the-cardiac-output-in-men-with-type-1-diabetes-during-the-maximal-exercise-test
#12
Pawel Niedzwiecki, Dariusz Naskret, Stanislaw Pilacinski, Maciej Pempera, Aleksandra Uruska, Anna Adamska, Dorota Zozulinska-Ziolkiewicz
BACKGROUND: The aim of this study was to assess the hemodynamic parameters analyzed in bioimpedance cardiography during maximal exercise in patients with type 1 diabetes differing in insulin resistance. METHODS: The study group consisted of 40 men with type 1 diabetes. Tissue sensitivity to insulin was assessed on the basis of the glucose disposal rate (GDR) analyzed during hyperinsulinemic-euglycemic clamp. Patients were divided into groups with GDR <4.5 mg/kg/min (G1 group-lower insulin sensitivity) and GDR ≥4...
June 2017: Metabolic Syndrome and related Disorders
https://www.readbyqxmd.com/read/28394183/assessing-the-impact-of-insulin-glargine-and-detemir-treatment-to-serum-total-igf1-levels-in-the-insulin-naive-type-2-diabetic-patients
#13
Soner Cander, Ozen Oz Gul, Oguzhan Sitki Dizdar, Nizameddin Koca, Taner Aydın, Emre Sarandol, Canan Ersoy
AIM: The mitogenic potential of analog insulins due to their different insulin-like growth factor-1 (IGF1) receptor affinity is a situation that causes concern related to cancer risk. We aimed to examine the changes in the serum IGF1 levels formed by insulin glargine and detemir in the insulin-naive type 2 diabetic patients. METHODS: The serum total IGF1 levels of the 62 insulin-naive type 2 diabetic patients were studied before and after 12 weeks of the started treatment with basal insulin analogs...
June 2017: Metabolic Syndrome and related Disorders
https://www.readbyqxmd.com/read/28358621/time-dependent-differences-in-the-influence-of-perivascular-adipose-tissue-on-vasomotor-functions-in-metabolic-syndrome
#14
Satomi Kagota, Saki Iwata, Kana Maruyama, John J McGuire, Kazumasa Shinozuka
BACKGROUND: Metabolic syndrome (MetS) facilitates the development of cardiovascular disease due to atherosclerosis, which is accelerated by defects of the vascular endothelium. Vascular dysfunction in response to nitric oxide (NO) occurs in the mesenteric arteries of an animal model of MetS, SHRSP.Z-Lepr(fa)/IzmDmcr (SHRSP.ZF) rats. Vascular responses to vasodilators are affected by perivascular adipose tissue (PVAT) that surrounds the outsides of arteries. In this study, we assessed the role of PVAT in vascular dysfunction observed in SHRSP...
June 2017: Metabolic Syndrome and related Disorders
https://www.readbyqxmd.com/read/28346859/circulating-zbed3-levels-in-subjects-with-and-without-metabolic-syndrome
#15
Wenjing Hu, Bo Tian, Xiaoqiang Li, Ling Li, Lin Zhang, Hua Liu, Gangyi Yang, Yongsheng Liu, Xiaoyun Fan
BACKGROUND: Zinc-finger BED domain-containing 3 (Zbed3) is a member of the zinc-finger domain protein superfamily. Recent studies have shown that Zbed3 is associated with insulin resistance and type 2 diabetes mellitus. However, no report has demonstrated the association of Zbed3 with metabolic syndrome (MetS) in humans. The purpose of this study is to examine the association between Zbed3 and MetS in a cross-sectional study. METHODS: We conducted a cross-sectional study of a Chinese population, including 167 non-MetS subjects and 144 newly diagnosed MetS (nMetS) patients...
June 2017: Metabolic Syndrome and related Disorders
https://www.readbyqxmd.com/read/28346857/the-influence-of-epicardial-fat-and-nonalcoholic-fatty-liver-disease-on-heart-rate-recovery-in-metabolic-syndrome
#16
Kyoung Im Cho, Eun Ah Jo, Sang Hoon Cho, Bo Hyun Kim
BACKGROUND: Epicardial adipose tissues reflecting visceral fat accumulations of the heart are associated with metabolic syndrome (MetS) and can be a predictor of other cardiometabolic diseases. It can adversely influence autonomic nervous system (ANS) of heart. Heart rate recovery (HRR) is an easy method for measuring ANS dysfunction. The purpose of this study was to determine whether epicardial fat thickness (EFT) and nonalcoholic fatty liver disease (NAFLD) are related to HRR in patients with MetS...
June 2017: Metabolic Syndrome and related Disorders
https://www.readbyqxmd.com/read/28346853/high-prevalence-of-vitamin-d-deficiency-and-correlation-of-serum-vitamin-d-with-cardiovascular-risk-in-patients-with-metabolic-syndrome
#17
Mohammad J Alkhatatbeh, Khalid K Abdul-Razzak, Lubna Q Khasawneh, Nesreen A Saadeh
BACKGROUND: Metabolic syndrome (MetS) identifies subjects with increased risk of cardiovascular disease when they have a combination of insulin resistance, obesity, hypertension, hyperglycemia, low high-density lipoprotein cholesterol (HDL-C), and elevated triglycerides (TGs). Increasing evidence suggests that vitamin D deficiency could be associated with diabetes and MetS. The aim is to assess if 25-hydroxyvitamin D (25-OHD) is correlated with cardiovascular risk components of MetS. METHODS: A cross-sectional study involved 124 diabetic patients with MetS according to International Diabetes Federation definition...
June 2017: Metabolic Syndrome and related Disorders
https://www.readbyqxmd.com/read/28318405/the-association-between-age-related-hearing-impairment-and-metabolic-syndrome-in-korean-women-5-year-follow-up-observational-study
#18
Tae Su Kim, Eun Hui Kim, Jong Woo Chung
BACKGROUND: Although several observational studies showed a relationship between various conditions of metabolic syndrome (MetS) and hearing threshold, there are no studies about longitudinal audiometric results related MetS. The aim of this study was to investigate the association between MetS and age-related hearing impairment (ARHI) through a large, average 5-year longitudinal follow-up, clinical comparative analysis. MATERIALS AND METHODS: We recruited 1381 women older than 50 years who were enrolled in 2007 and reevaluated in 2012...
June 2017: Metabolic Syndrome and related Disorders
https://www.readbyqxmd.com/read/28318384/increased-adipose-and-muscle-insulin-sensitivity-without-changes-in-serum-adiponectin-in-young-female-collegiate-athletes
#19
Kaori Kitaoka, Mika Takeuchi, Ayaka Tsuboi, Satomi Minato, Miki Kurata, Shigehiro Tanaka, Tsutomu Kazumi, Keisuke Fukuo
BACKGROUND: Effects of endurance training on adipose insulin sensitivity in association with body composition, circulating adipokines, and markers of inflammation have been studied less in young Asian subjects. METHODS: Adipose insulin sensitivity/resistance was compared between 170 female Japanese collegiate athletes and 311 nonathletes (18-24 years), who underwent measurements of serum adipokines, markers of insulin sensitivity, inflammation, and dual-energy X-ray absorptiometry...
June 2017: Metabolic Syndrome and related Disorders
https://www.readbyqxmd.com/read/28557564/metabolic-syndrome-among-leukemia-survivors-still-delineating-the-risk
#20
Paul Saultier, Claire Oudin, Gérard Michel
No abstract text is available yet for this article.
May 22, 2017: Metabolic Syndrome and related Disorders
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