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Metabolic Syndrome and related Disorders

Christian Brinkmann, Benedikt Schulte-Körne, Marijke Grau, Sinja Obels, Roman Kemmerling, Thorsten Schiffer, Wilhelm Bloch, Klara Brixius
BACKGROUND: Increases in the amount of inducible nitric oxide synthase (iNOS) protein and abnormal production of nitric oxide (NO) in skeletal muscle have been suggested to be associated with peripheral insulin resistance in patients with type 2 diabetes mellitus (T2DM). This pilot study analyzed whether a 3-month endurance training can affect iNOS protein and NO metabolite levels in the vastus lateralis muscle of insulin-independent T2DM men, thereby affecting the patients` glycemic control...
October 26, 2016: Metabolic Syndrome and related Disorders
Jacinthe Leclerc, Marie Arsenault, Jean-Pierre Després, Patrice Brassard, Valérie Gaudreault, Jean Bergeron, Natalie Alméras, Angelo Tremblay, Audrey Auclair, Marie-Kristelle Ross, Stéphanie Denault-Bissonnette, Paul Poirier
BACKGROUND: Abdominal obesity and presence of the metabolic syndrome (MetS) are associated with cardiac abnormalities. Among those, left ventricular diastolic dysfunction (LVDD) is the most frequently encountered in clinical practice. Few studies evaluated the reversibility of LVDD by an approach promoting lifestyle modifications in abdominally obese subjects with MetS. METHODS: We assessed the impact of a 1-year lifestyle modification program combining nutritional and physical activity counseling on LVDD and metabolic profile of abdominally obese men with MetS...
October 18, 2016: Metabolic Syndrome and related Disorders
Vendela Roos, Sölve Elmståhl, Erik Ingelsson, Johan Sundström, Johan Ärnlöv, Lars Lind
BACKGROUND: Obesity and its associated metabolic complications continue to increase worldwide. We investigated the development of metabolic syndrome (MetS) during aging in relation to body mass index (BMI) and exercise habits. We assigned special emphasis to the metabolic stability in individuals with obesity, but without MetS, a condition often referred to as metabolically healthy obesity. MATERIALS AND METHODS: Cross-sectional analysis was carried out in a sample of 19,129 men and women aged 45-75 years from the EpiHealth study...
October 18, 2016: Metabolic Syndrome and related Disorders
Toyoko Morita, Yoji Yamazaki, Chika Fujiharu, Takanori Ishii, Misae Seto, Norihide Nishinoue, Yoshiyuki Sasaki, Kumiko Nakai, Hideki Tanaka, Takayuki Kawato, Masao Maeno
BACKGROUND: Epidemiological studies have reported that periodontitis and cardiometabolic disease such as cardiovascular disease and type 2 diabetes are associated; however, there have been very few prospective cohort studies on this topic. Therefore, we conducted a 9-year follow-up study to examine the relationship between the duration of periodontitis and cardiometabolic risk factors, including hypertension, hyperglycemia, dyslipidemia, and obesity. METHODS: The study participants comprised 572 adult industrial workers (417 men and 155 women; mean age, 37...
October 14, 2016: Metabolic Syndrome and related Disorders
Naval K Vikram, Ahmad Nawid Latifi, Anoop Misra, Kalpana Luthra, Surya Prakash Bhatt, Randeep Guleria, Ravindra M Pandey
OBJECTIVE: The aim of this study was to compare the discriminatory ability of body mass index (BMI), waist circumference (WC), waist-to-hip ratio (WHR), and waist-to-height ratio (WHtR) in identifying the presence of cardiometabolic risk factors in Asian Indians. METHODS: This cross-sectional study involved 509 subjects (278 males and 231 females) aged 20-60 years from New Delhi, India. Measurements included complete clinical examination, blood pressure, weight, height, WC, BMI, WHR and WHtR, fasting blood glucose, lipid profile, and fasting insulin levels...
October 14, 2016: Metabolic Syndrome and related Disorders
Nirvair S Kelley
BACKGROUND: Nonalcoholic fatty liver disease (NAFLD) is a major risk factor for type 2 diabetes, cardiovascular disease, and liver failure. Treatment with n-3 long-chain polyunsaturated fatty acids (n-3 LCPUFAs) produced variable success in improving NAFLD. The purpose of this review is to determine if n-3 LCPUFA will decrease markers of NAFLD, compare the efficacies of eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA), and identify factors that contribute to discrepancies in results...
October 6, 2016: Metabolic Syndrome and related Disorders
Hack-Lyoung Kim, Myung-A Kim, Sohee Oh, Mina Kim, Seong Mi Park, Hyun Ju Yoon, Mi Seung Shin, Kyung-Soon Hong, Gil Ja Shin, Wan-Joo Shim
BACKGROUND: Sex-related differences in the influence of metabolic syndrome (MetS) on various cardiovascular diseases have been suggested. The aim of this study was to investigate the effect of sex on the association between MetS and left ventricular (LV) diastolic dysfunction in patients with suspected coronary artery disease (CAD). METHODS: Two hundred ten patients (105 men and age-matched 105 women; mean age: 56.5 ± 10.9 years) undergoing elective coronary angiography for the evaluation of CAD were studied...
October 6, 2016: Metabolic Syndrome and related Disorders
Liling Deng, Songfang Liu, Yuan Gong, Haoming Tian, Yuanyuan Liu, Jie Song, Xingwu Ran, Honglin Yu, Xiangxun Zhang, Yang Long, Yan Ren
OBJECTIVE: To compare the metabolic status and pancreatic β-cell function in first-degree relatives (FDRs) of type 2 diabetic patients with normal glucose tolerance (NGT). MATERIALS AND METHODS: Three hundred twelve subjects, who were NGT-FDR of type 2 diabetic patients and 1348 subjects, who were NGT individuals with no family history of diabetes, were defined as NGT-FDRs and NGT-controls (NGT-C), respectively. Blood pressure, body weight, waist circumference, plasma glucose, lipid profile, and insulin levels were measured in all subjects...
September 30, 2016: Metabolic Syndrome and related Disorders
Julie K K Vishram, Tine W Hansen, Christian Torp-Pedersen, Sten Madsbad, Torben Jørgensen, Mogens Fenger, Stig Lyngbæk, Jørgen Jeppesen
BACKGROUND: Common lipoprotein lipase (LPL) variants are important determinants of triglycerides (TG) and high-density lipoprotein (HDL) cholesterol (C) concentrations. High TG/low HDL-C tend to cluster with hypertension, glucose intolerance, and abdominal obesity and comprise the metabolic syndrome (MetS). The role of LPL variants as a cause of MetS is unclear. This study investigated the relationship between two common LPL variants and the presence of MetS and its individual components...
September 27, 2016: Metabolic Syndrome and related Disorders
Sasa Dusanov, Eli Heggen, Serena Tonstad
BACKGROUND: Metabolic syndrome (MetSyn) magnifies risks of cardiovascular disease (CVD) and type 2 diabetes, but its expression varies within the obese population. We examined body mass index (BMI), metabolic traits, and fat distribution in morbidly obese individuals. METHODS: Lipids and inflammatory, oxidative stress and hepatic biomarkers in 346 women and 203 men (BMI ≥35 kg/m(2) and co-morbidity or ≥40 kg/m(2)) were stratified by MetSyn components (1-5, excluding diabetes)...
August 11, 2016: Metabolic Syndrome and related Disorders
Robinson Ramírez-Vélez, Alejandro Anzola, Javier Martinez-Torres, Andres Vivas, Alejandra Tordecilla-Sanders, Daniel Prieto-Benavides, Mikel Izquierdo, Jorge Enrique Correa-Bautista, Antonio Garcia-Hermoso
BACKGROUND: In contrast to the definition of metabolic syndrome (MetS) in adults, there is no standard definition of MetS in pediatric populations. We aimed at assessing the differences in the prevalence of MetS in children and adolescents aged 9-17 years using four different operational definitions for these age groups and at examining the associated variables. METHODS: A total of 675 children and 1247 adolescents attending public schools in Bogota (54.4% girls; age range 9-17...
August 10, 2016: Metabolic Syndrome and related Disorders
Magel Costa, María Luisa Garmendia, Camila Corvalán, Marcela Reyes
BACKGROUND: Overweight is associated with low-grade inflammation, but it is under debate whether the effect of fat mass accumulation is acute or chronic. We aimed to study the association of overweight duration with low-grade inflammation in children in whom overweight initiation can be established. METHODS: Observational longitudinal study, including a subsample of 250 Chilean children from the Growth and Obesity Cohort Study followed-up yearly since preschool age (n = 1195)...
August 1, 2016: Metabolic Syndrome and related Disorders
Arthur L M Swislocki, Ishwarlal Jialal
No abstract text is available yet for this article.
October 2016: Metabolic Syndrome and related Disorders
Benedetta Maria Bonora, Gian Paolo Fadini
The metabolic syndrome (MS) and subclinical hypothyroidism (SCH) are highly prevalent in the general population. Cross-sectional epidemiological data suggest that a mutual association exists between the two, although the cause-effect relationship remains poorly elucidated. As SCH raises cholesterol, blood pressure, and visceral fat, it is easy to understand why it associates with MS. Rather, the reasons whereby MS patients are at higher risk for SCH are less apparent. Some studies have reported that SCH is itself characterized by high cardiovascular risk...
October 2016: Metabolic Syndrome and related Disorders
Muni Rubens, Venkataraghavan Ramamoorthy, Anshul Saxena, Florence George, Nancy Shehadeh, Jennifer Attonito, H Virginia McCoy, Consuelo M Beck-Sagué
BACKGROUND: Metabolic syndrome is increasingly common in U.S. adolescents and has been linked to cognitive dysfunction. Purpose of this study is to explore associations between metabolic syndrome and cognitive impairment in U.S. adolescents using population-based data. STUDY DESIGN: Participants included adolescents aged 12-16 years who participated in the National Health and Nutrition Examination Survey (NHANES) III. The main outcome measures included assessments of cognitive function using Wide Range Achievement Test-Revised (WRAT-R) and Wechsler Intelligence Scale for Children-Revised (WISC-R) tools...
October 2016: Metabolic Syndrome and related Disorders
Sasa Dusanov, Kari Brandal, Eli Heggen, Serena Tonstad
BACKGROUND: The gut hormone peptide YY3-36 (PYY3-36) plays major roles in regulation of appetite and energy metabolism, mediates beneficial effects of bariatric surgery, and may be a potential weight-reducing and glucose-modulating therapy. Obesity may influence the metabolic expression of circulating PYY3-36 and metabolic markers. We studied the relationship of PYY3-36 concentrations with metabolic syndrome (MetSyn) components, lipids, insulin resistance, and inflammatory biomarkers in subjects with extreme obesity...
October 2016: Metabolic Syndrome and related Disorders
Yen-Lin Chen, Shu-Fen Lee, Chun Pei, Dee Pei, Chien-Hsing Lee, Chih-Tsueng He, Yao-Jen Liang, Jiunn-Diann Lin
BACKGROUND: Glucose effectiveness (GE) is the capacity of glucose to increase its own uptake and to maintain endogenous hepatic glucose output under basal insulin levels. In addition to decreased insulin sensitivity (IS) and impaired insulin secretion, GE plays a critical role in glucose balance in patients with type 2 diabetes (T2DM). In the study, we developed an equation for predicting GE. METHODS: We enrolled 227 participants with glucose tolerances ranging from normal glucose tolerance to diabetes...
October 2016: Metabolic Syndrome and related Disorders
Rachel-Marie Cazeau, Lindsey Rauch, Hong Huang, John A Bauer, Robert P Hoffman
BACKGROUND: Black adolescents are at increased risk of cardiometabolic disease but have lower fasting triglyceride, which is usually associated with decreased risk. No one has studied racial differences in triglycerides or free fatty acids (FFAs) after a high-fat meal. METHODS: Oral glucose tolerance testing was used to assess insulin secretion, sensitivity, and disposition index (DI). Endothelial function, triglycerides, FFA, c-reactive protein, interleukin 6 (IL6), and adiponectin were measured both pre- and 3 hr postprandially (McDonald's Big Breakfast(®) and 12 ounce Sprite(®)) in obese adolescents (10-13 years, 9 black and 7 white)...
September 2016: Metabolic Syndrome and related Disorders
Julia Christenson, Serena J Whitby, Duane Mellor, Jackson Thomas, Andrew McKune, Paul D Roach, Nenad Naumovski
BACKGROUND: Obesity and metabolic syndrome are significant global health issues, with current public health messages predominately focused on altering dietary and physical activity behaviors. Resveratrol is a polyphenol (stilbenoid) commonly found in grapes, and human trials to date have shown conflicting and limited beneficial effects with respect to health. The aim of this study was to determine the effect of resveratrol supplementation on reducing body weight and modifying associated inflammatory markers...
September 2016: Metabolic Syndrome and related Disorders
Guihua Yang, Na Liu, Mei Hu, Xuli Xin, Jing Han, Yuyu Cai, Zhiying Hu, Chundi Jia, Man Zhang
BACKGROUND: Elevated free fatty acids (FFAs) are thought to play an important role in the development of insulin resistance. Adiponectin is an adipose tissue-secreted protein known for its effects on the stimulation of fatty acid oxidation. The aim of this study was to investigate the association of adiponectin receptor 2 gene variations with FFAs levels in subjects with normal fasting glucose levels in Chinese Han population. METHODS: Four common single nucleotide polymorphisms of ADIPOR2 were genotyped using the TaqMan method to perform association studies with metabolic parameters in 1819 subjects among Chinese Han population...
September 2016: Metabolic Syndrome and related Disorders
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