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Metabolic Syndrome and related Disorders

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https://www.readbyqxmd.com/read/28922061/alanine-aminotransferase-and-total-bilirubin-are-synergistically-associated-with-metabolic-syndrome-among-middle-aged-and-elderly-japanese-women
#1
Ryuichi Kawamoto, Daisuke Ninomiya, Kensuke Senzaki, Teru Kumagi
BACKGROUND: Metabolic syndrome (MetS) is associated with an increased risk of major cardiovascular events. Alanine aminotransferase (ALT) at high levels and total bilirubin (T-BiL) at low levels were oxidative potentials, but it was uncertain whether ALT and T-BiL had an additive interaction for the risk of MetS. METHODS: From a single community, we recruited 864 women (70 ± 8 years) during their annual health examination. We cross-sectionally investigated whether ALT and T-BiL are associated with MetS and its components based on the modified criteria of the National Cholesterol Education Program's Adult Treatment Panel (NCEP-ATP) III report...
September 18, 2017: Metabolic Syndrome and related Disorders
https://www.readbyqxmd.com/read/28922059/the-currency-of-science
#2
Adrian Vella
No abstract text is available yet for this article.
September 18, 2017: Metabolic Syndrome and related Disorders
https://www.readbyqxmd.com/read/28910195/elevated-neutrophil-to-lymphocyte-ratio-in-metabolic-syndrome-is-associated-with-increased-risk-of-colorectal-adenoma
#3
Jae Hyun Kim, Kyoung Im Cho, Young A Kim, Seun Ja Park
BACKGROUND: Metabolic syndrome (MetS) is an important cardiovascular risk factor for insulin resistance and has been linked to colorectal adenoma via inflammation. The neutrophil-to-lymphocyte ratio (NLR) has been suggested as an important inflammatory marker. We initiated this investigation to determine the relationship between colorectal adenoma and NLR in patients with MetS. METHODS: We examined participants who visited the Health Promotion Center at Kosin University Gospel Hospital, Busan, Korea...
September 14, 2017: Metabolic Syndrome and related Disorders
https://www.readbyqxmd.com/read/28846061/obstetric-outcomes-in-women-with-nonalcoholic-fatty-liver-disease
#4
Yeon Woo Lee, Christina D Yarrington
BACKGROUND: Nonalcoholic fatty liver disease (NAFLD) is one of the most common chronic liver diseases in the Western world and yet there is little research into its impact on pregnancy. METHODS: A literature review was conducted in the database PubMed, with articles published between 1990 and 2017. The selected studies addressed features specifically attributed to NAFLD and associated obstetric and neonatal outcomes. Nine studies met criteria. Our aim was to consolidate the limited literature and identify trends...
August 28, 2017: Metabolic Syndrome and related Disorders
https://www.readbyqxmd.com/read/28832275/association-between-obesity-and-chronic-kidney-disease-defined-by-both-glomerular-filtration-rate-and-albuminuria-in-korean-adults
#5
Yoon Ji Kim, Seun Deuk Hwang, Tae Jung Oh, Kyoung Min Kim, Hak Chul Jang, Heejin Kimm, Hyeon Chang Kim, Sun Ha Jee, Soo Lim
BACKGROUND: Chronic kidney disease (CKD) has often been defined based on glomerular filtration rate (GFR) alone. The Kidney Disease: Improving Global Outcomes guideline highlights albuminuria in the CKD definition. Thus, we investigated the association between obesity and CKD, as defined by both GFR and albuminuria, in Korean adults. METHODS: We used Korea National Health and Nutrition Examination Survey 2011-2014 data (N = 19,331, ≥19 years old) representing the national Korean population...
August 23, 2017: Metabolic Syndrome and related Disorders
https://www.readbyqxmd.com/read/28829247/distinct-predictors-and-comorbidities-in-early-onset-type-2-diabetes-mellitus-among-asian-indians
#6
Gadadharan Vijayakumar, Ganapathy K Sreehari, Aswathi Vijayakumar, Abdul Jaleel
BACKGROUND: The incidence of type 2 diabetes mellitus (T2DM) is increasing worldwide, and the age of disease onset is falling. Although there is rising prevalence of early onset T2DM in India, little is known about their clinical characteristics and cardiovascular risks profiles. The aim of this study was to address this knowledge gap by comparing the characteristics of early onset T2DM and usual onset T2DM patients from our clinic population in India. METHODS: We studied the clinical and biochemical parameters of 98 consecutive early onset T2DM patients of age <45 and <5 years of disease duration and compared those parameters with 86 consecutive usual onset T2DM patients of age >50 years and similar disease duration...
August 22, 2017: Metabolic Syndrome and related Disorders
https://www.readbyqxmd.com/read/28829223/metabolic-syndrome-in-hispanic-youth-results-from-the-hispanic-community-children-s-health-study-study-of-latino-youth
#7
Samantha A Reina, Maria M Llabre, Denise C Vidot, Carmen R Isasi, Krista Perreira, Mercedes Carnethon, Christina M Parrinello, Linda C Gallo, Guadalupe X Ayala, Alan Delamater
BACKGROUND: Metabolic syndrome (MetS), a cluster of cardiovascular risk factors, is being diagnosed in youth. Specific diagnostic criteria used to define MetS influence prevalence estimates and populations considered at risk for cardiovascular disease. The National Cholesterol Education Program's Adult Treatment Panel III (ATP), the World Health Organization (WHO), and the International Diabetes Federation (IDF) provide three MetS definitions used in medical research. This study examined concordance among these definitions in 1137 children 10-16 years of age, who participated in the Hispanic Community Children's Health Study/Study of Latino Youth...
August 22, 2017: Metabolic Syndrome and related Disorders
https://www.readbyqxmd.com/read/28749722/association-between-plasma-proprotein-convertase-subtilisin-kexin-type-9-and-the-presence-of-metabolic-syndrome-in-a-predominantly-rural-based-sub-saharan-african-population
#8
Martine Paquette, Yascara Grisel Luna Saavedra, Ann Chamberland, Annik Prat, Dirk Lund Christensen, Fannie Lajeunesse-Trempe, Lydia Kaduka, Nabil G Seidah, Robert Dufour, Alexis Baass
BACKGROUND: The prevalence of metabolic syndrome (MetS) has increased dramatically in low- and middle-income countries. Proprotein convertase subtilisin/kexin type 9 (PCSK9) plays a major role in low-density lipoprotein receptor degradation, but its relationship with metabolic parameters is still poorly understood. We aimed to investigate the association between plasma PCSK9 and metabolic parameters in a Kenyan cohort. METHODS: Total plasma PCSK9 levels were measured in 2016 by an in-house enzyme-linked immunosorbent assay using a polyclonal antibody...
July 27, 2017: Metabolic Syndrome and related Disorders
https://www.readbyqxmd.com/read/28846513/low-volume-high-intensity-interval-training-is-sufficient-to-ameliorate-the-severity-of-metabolic-syndrome
#9
Joyce S Ramos, Lance C Dalleck, Fabio Borrani, Kassia S Beetham, Matthew P Wallen, Alistair R Mallard, Bronwyn Clark, Sjaan Gomersall, Shelley E Keating, Robert G Fassett, Jeff S Coombes
BACKGROUND: High-intensity interval training (HIIT) is superior to moderate-intensity continuous training (MICT) at improving cardiometabolic risk. However, the optimal volume of HIIT to reduce the severity of the metabolic syndrome (MetS) has yet to be investigated. The aim of this study was to examine the impact of different volumes of HIIT and MICT on MetS severity (MetS z-score). METHODS: This was a substudy of the "Exercise in prevention of Metabolic Syndrome" (EX-MET) multicenter trial, reporting data collected at the Brisbane site...
September 2017: Metabolic Syndrome and related Disorders
https://www.readbyqxmd.com/read/28759349/association-between-handgrip-muscle-strength-and-cardiometabolic-z-score-in-children-6-to-19-years-of-age-results-from-the-canadian-health-measures-survey
#10
Brittany V Rioux, Paul Kuwornu, Atul Sharma, Mark S Tremblay, Jonathan M McGavock, Martin Sénéchal
BACKGROUND: It is unclear if muscle strength, another index of fitness, which confers the protection from cardiometabolic risk in adults, is associated with similar protection in children and youth. The purpose of this study was to investigate the association between handgrip strength and cardiometabolic health in a large Canadian sample of children and youth. METHODS: We performed a cross-sectional analysis of the Canadian sample of children and youth aged 6 to 19 years (n = 1376) studied in the Canadian Health Measures Survey (cycles 1 and 2) between 2007 and 2011...
September 2017: Metabolic Syndrome and related Disorders
https://www.readbyqxmd.com/read/28737448/mast-cell-and-m1-macrophage-infiltration-and-local-pro-inflammatory-factors-were-attenuated-with-incretin-based-therapies-in-obesity-related-glomerulopathy
#11
Jiao He, Geheng Yuan, Fangxiao Cheng, Junqing Zhang, Xiaohui Guo
BACKGROUND: The global increase of obesity parallels the obesity-related glomerulopathy (ORG) epidemic. Dipeptidyl peptidase 4 inhibitors and glucagon-like peptide-1 receptor agonists were well recognized to attenuate renal injury independent of glucose control in diabetic nephropathy. There are limited studies focusing on their effects on ORG. We explored the effects of incretin-based therapies on early ORG and the inflammatory responses involved mainly concentrated on mast cell (MC) and macrophage (M) infiltration and local pro-inflammatory factors...
September 2017: Metabolic Syndrome and related Disorders
https://www.readbyqxmd.com/read/28727953/fatty-acid-composition-of-plasma-phosphatidylcholine-determines-body-fat-parameters-in-subjects-with-metabolic-syndrome-related-traits
#12
Miroslav Zeman, Marek Vecka, Michal Burda, Eva Tvrzická, Barbora Staňková, Jaroslav Macášek, Aleš Žák
BACKGROUND: This study examines the associations of fatty acids (FAs) in plasma phosphatidylcholine (PC) with the anthropometrical and biochemical characteristic of patients with metabolic syndrome (MetS)-related traits. METHODS: We analyzed the FA profiles of PC in 300 persons with MetS-related traits (152 M/148F, mean age 46.9 ± 9.0 years) and in 70 healthy controls of the same age using a balanced men/women ratio and gas-liquid chromatography. Multivariate linear regression analysis was performed to determine the coefficients of determination (R(2)) using FA proportions of the mentioned proband characteristics...
September 2017: Metabolic Syndrome and related Disorders
https://www.readbyqxmd.com/read/28727943/the-genetic-background-of-metabolic-trait-clusters-in-children-and-adolescents
#13
Karri Silventoinen, Élvio Gouveia, Aline Jelenkovic, José Maia, António M Antunes, Miguel A A Pinheiro de Carvalho, António M Brehm, Martine Thomis, Johan Lefevre, Jaakko Kaprio, Duarte Freitas
BACKGROUND: It is well known that metabolic risk factors of cardiovascular diseases are correlated, but the background of this clustering in children is more poorly known than in adults. Thus, we studied the contribution of genetic and environmental factors to the clustering of metabolic traits in childhood and adolescence. DATA AND METHODS: Nine metabolic traits were measured in 214 complete twin pairs aged 3-18 years in the Autonomous Region of Madeira, Portugal, in 2007 and 2008...
September 2017: Metabolic Syndrome and related Disorders
https://www.readbyqxmd.com/read/28677982/determinants-of-incident-metabolic-syndrome-in-a-middle-eastern-population-isfahan-cohort-study
#14
Naeimeh Hosseini, Mohammad Talaei, Minoo Dianatkhah, Masoumeh Sadeghi, Shahram Oveisgharan, Nizal Sarrafzadegan
BACKGROUND: To identify the associated risk factors with development of metabolic syndrome (MetS) in a longitudinal prospective cohort study in an Iranian population. METHODS: A total of 1994 participants, aged ≥35 years, free of MetS, diabetes, and cardiovascular disease at baseline were followed up for 7 years. Physical examination, laboratory studies, and interview about lifestyle factors were performed, and MetS was defined based on harmonized definition at both time points...
September 2017: Metabolic Syndrome and related Disorders
https://www.readbyqxmd.com/read/28586263/the-interplay-between-fat-mass-and-fat-distribution-as-determinants-of-the-metabolic-syndrome-is-sex-dependent
#15
Lars Lind, Johan Ärnlöv, Erik Lampa
BACKGROUND: Fat mass and fat distribution are major determinants of the metabolic syndrome (MetS), but the interplay between them has not been thoroughly investigated. In addition, fat mass and fat distribution are generally different in men than in women. We aimed to determine whether the interplay between fat mass and fat distribution regarding MetS and its components is sex-dependent using data from the large-scale population-based sample EpiHealth. METHODS: Occurrence of MetS and its components was determined together with fat mass by bioimpedance in 19,094 participants in the EpiHealth sample [mean age 61 years (SD 8...
September 2017: Metabolic Syndrome and related Disorders
https://www.readbyqxmd.com/read/28570830/comparison-of-three-adiposity-indexes-and-cutoff-values-to-predict-metabolic-syndrome-among-university-students
#16
Jorge Enrique Correa-Bautista, Katherine González-Ruíz, Andrés Vivas, Héctor Reynaldo Triana-Reina, Javier Martínez-Torres, Daniel Humberto Prieto-Benavides, Hugo Alejandro Carrillo, Jeison Alexander Ramos-Sepúlveda, María Isabel Afanador-Rodríguez, Emilio Villa-González, Antonio García-Hermoso, Robinson Ramírez-Vélez
PURPOSE: Obesity and high body fat are related to diabetes and metabolic syndrome (MetS) in all ethnic groups. Based on the International Diabetes Federation (IDF) definition of MetS, the aim of the present study was to compare body adiposity indexes (BAIs) and to assess their various cutoff values for the prediction of MetS in university students from Colombia. METHODS: A cross-sectional study was conducted on 886 volunteers (51.9% woman; age mean 21.4 years). Anthropometric characteristics (height, weight, waist circumference [WC], and hip circumference [HC]) were measured, and body composition was assessed by bioelectrical impedance analysis...
September 2017: Metabolic Syndrome and related Disorders
https://www.readbyqxmd.com/read/28657427/expression-of-metabolic-syndrome-in-women-with-severe-obesity
#17
James L Hopkins, Paul N Hopkins, Eliot A Brinton, Ted D Adams, Lance E Davidson, M Nazeem Nanjee, Steven C Hunt
BACKGROUND: The prevalence of metabolic syndrome (MetS) generally rises with increasing adiposity, but tends to plateau at the highest levels of body mass index (BMI) with some individuals, even with severe obesity, expressing few or no components of MetS. We examined factors associated with the expression of MetS in severely obese women participating in a large observational study. METHODS: Anthropometrics, including Heath equation-adjusted bioimpedance-determined fat-free mass (FFM) and fat mass (FM), lipids and related laboratory measurements, resting energy expenditure (REE), and respiratory quotient (RQ), were studied in 949 women with severe obesity...
August 2017: Metabolic Syndrome and related Disorders
https://www.readbyqxmd.com/read/28605281/re-plasminogen-activator-inhibitor-1-and-pericardial-fat-in-individuals-with-type-2-diabetes-mellitus-by-bayomi-et-al-metab-syndr-relat-disord-2017-15-269-275
#18
Angelo Avogaro
Plasminogen activator inhibitor-1 (PAI-1) is a member of the serine protease inhibitor (serpin) superfamily, which inactivates tissue plasminogen activator (tPA); therefore, increased level of PAI-1 antigen counteracts the anticoagulant effect of tPA and facilitates the fibrin clot formation. Plasma PAI-1 antigen and activity levels are associated with increased body mass index and with features of the insulin resistance syndrome like obesity and diabetes. Visceral adipose tissue produces more PAI-1 than subcutaneous adipose tissue: This increased production of PAI-1 from the visceral adipose tissue is one important link between visceral obesity and cardiovascular disease...
August 2017: Metabolic Syndrome and related Disorders
https://www.readbyqxmd.com/read/28605280/the-gut-a-key-to-the-pathogenesis-of-type-2-diabetes
#19
Jens Juul Holst, Jens Pedersen, Nicolai Jacob Wewer Albrechtsen, Filip Krag Knop
In this communication we discuss the role of the gut for the development of type 2 diabetes mellitus (T2DM). Gastric emptying rates importantly determine postprandial glucose excursions and regulate postprandial secretion of the incretin hormones, glucose-dependent insulinotropic polypeptide (GIP), and glucagon-like peptide-1 (GLP-1). It thereby also determines their powerful, amplifying effect on glucose-induced insulin secretion and thus the ability of the body to regulate glucose disposal. Although disturbances in gastric emptying are not consistent findings in type 2 diabetes, the incretin system is seriously impaired, probably associated with insulin resistance and obesity...
August 2017: Metabolic Syndrome and related Disorders
https://www.readbyqxmd.com/read/28520503/serum-alanine-aminotransferase-trends-and-their-relationship-with-obesity-and-metabolic-syndrome-in-united-states-adolescents-1999-2014
#20
Cyrelle R Fermin, Arthur M Lee, Stephanie L Filipp, Matthew J Gurka, Mark D DeBoer
INTRODUCTION: Nonalcoholic fatty liver disease (NAFLD), characterized by hepatocyte dysfunction, fat accumulation, and fibrosis, is the most common cause of chronic liver disease in children. Elevated levels of serum alanine aminotransferase (ALT) are used clinically to identify potential liver dysfunction. Our goal was to assess for changes in the national prevalence of elevated ALT over time and potential relationship to trends in the metabolic syndrome (MetS) severity and elevated body mass index (BMI)...
August 2017: Metabolic Syndrome and related Disorders
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