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Applied Health Economics and Health Policy

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https://www.readbyqxmd.com/read/28197805/economic-analysis-and-budget-impact-of-tenofovir-and-entecavir-in-the-first-line-treatment-of-hepatitis-b-virus-in-italy
#1
M Ruggeri, M Basile, S Coretti, C Drago, A Cicchetti
BACKGROUND: Chronic hepatitis B is a common, progressive disease, particularly when viral replication is detected. Oral antivirals can suppress viral replication and prevent or delay the development of cirrhosis and liver-related complications. The treatments of chronic hepatitis B cannot totally cure the disease but can prevent its progression to hepatocellular carcinoma, decreasing the levels of both morbidity and mortality. To date, there are several therapies indicated by the international guidelines as first-line treatments for the management of hepatitis B; two of the most effective are those based on either tenofovir or entecavir...
February 14, 2017: Applied Health Economics and Health Policy
https://www.readbyqxmd.com/read/28194657/eq-5d-and-the-euroqol-group-past-present-and-future
#2
REVIEW
Nancy J Devlin, Richard Brooks
Over the period 1987-1991 an inter-disciplinary five-country group developed the EuroQol instrument, a five-dimensional three-level generic measure subsequently termed the 'EQ-5D'. It was designed to measure and value health status. The salient features of its development and its consolidation and expansion are discussed. Initial expansion came, in particular, in the form of new language versions. Their development raised translation and semantic issues, experience with which helped feed into the design of two further instruments, the EQ-5D-5L and the youth version EQ-5D-Y...
February 13, 2017: Applied Health Economics and Health Policy
https://www.readbyqxmd.com/read/28185134/cost-effectiveness-models-in-breast-cancer-screening-in-the-general-population-a-systematic-review
#3
REVIEW
Irmgard C Schiller-Frühwirth, Beate Jahn, Marjan Arvandi, Uwe Siebert
BACKGROUND: Many Western countries have long-established population-based mammography screening programs. Prior to implementing these programs, decision-analytic modeling was widely used to inform decisions. OBJECTIVE: The aim of this study was to perform a systematic review of cost-effectiveness models in breast cancer screening in the general population to analyze their structural and methodological approaches. METHODS: A systematic literature search for health economic models was performed in the electronic databases MEDLINE (Ovid), EMBASE, CRD Databases, Cochrane Library, and EconLit in August 2011 with updates in June 2013, April 2015, and November 2016...
February 10, 2017: Applied Health Economics and Health Policy
https://www.readbyqxmd.com/read/28185133/geographic-resource-allocation-based-on-cost-effectiveness-an-application-to-malaria-policy
#4
Tom L Drake, Yoel Lubell, Shwe Sin Kyaw, Angela Devine, Myat Phone Kyaw, Nicholas P J Day, Frank M Smithuis, Lisa J White
Healthcare services are often provided to a country as a whole, though in many cases the available resources can be more effectively targeted to specific geographically defined populations. In the case of malaria, risk is highly geographically heterogeneous, and many interventions, such as insecticide-treated bed nets and malaria community health workers, can be targeted to populations in a way that maximises impact for the resources available. This paper describes a framework for geographically targeted budget allocation based on the principles of cost-effectiveness analysis and applied to priority setting in malaria control and elimination...
February 10, 2017: Applied Health Economics and Health Policy
https://www.readbyqxmd.com/read/28185132/erratum-to-malaria-and-economic-evaluation-methods-challenges-and-opportunities
#5
Tom L Drake, Yoel Lubell
No abstract text is available yet for this article.
February 10, 2017: Applied Health Economics and Health Policy
https://www.readbyqxmd.com/read/28164250/does-insurance-status-influence-a-patient-s-hospital-charge
#6
Lindsey Woodworth, Patrick S Romano, James F Holmes
BACKGROUND: There is obscurity regarding how US hospitals determine patients' charges. Whether insurance status influences a patient's hospital charge has not been explored. OBJECTIVE: The objective of this study was to determine whether hospitals charge patients differently based on their insurance status. METHODS: This was an analysis of the Florida Hospital Inpatient Data File for fiscal years 2011-2012 (N = 4.7 million). Multivariable regression analysis was used to adjust for patients' age, sex, length of stay, priority of admission, principal ICD-9-CM diagnosis, and All Payer Refined Diagnosis-Related Group subdivided by Severity of Illness subclass...
February 6, 2017: Applied Health Economics and Health Policy
https://www.readbyqxmd.com/read/28138932/drug-pricing-in-south-korea
#7
Hye-Young Kwon, Brian Godman
Between 2000 and 2013, spending on medicines in Korea increased by 275.3%. In order to curb this trend, several pricing policies and measures were introduced. This study reviews these policies and their implications based on pricing regulations as well as a literature review. New medicines now undergo both a reimbursement assessment and price negotiations. The reimbursement of new medicines is based on their cost effectiveness. The prices of new medicines are subsequently fixed through negotiations between the payer, the National Health Insurance Service, and the relevant manufacturer...
January 30, 2017: Applied Health Economics and Health Policy
https://www.readbyqxmd.com/read/28130691/a-review-of-nice-methods-and-processes-across-health-technology-assessment-programmes-why-the-differences-and-what-is-the-impact
#8
Emma Cowles, Grace Marsden, Amanda Cole, Nancy Devlin
BACKGROUND: Decisions made by the National Institute for Health and Care Excellence (NICE) exert an influence on the allocation of resources within 'fixed' National Health Service budgets. Yet guidance for different types of health interventions is handled via different 'programmes' within NICE, which follow different methods and processes. OBJECTIVE: The objective of this research was to identify differences in the processes and methods of NICE health technology assessment programmes and to explore how these could impact on allocative efficiency within the National Health Service...
January 27, 2017: Applied Health Economics and Health Policy
https://www.readbyqxmd.com/read/28120166/is-compulsory-licensing-bad-for-public-health-some-critical-comments-on-drug-accessibility-in-developing-countries
#9
Samira Guennif
As one of the flexibilities provided by the agreement on Trade-Related Aspects of Intellectual Property Rights (TRIPS) establishing minimum standards for the protection of property rights, compulsory license (CL) represents a means towards the protection of public health issues within a context of stringent protection of intellectual property rights (IPRs), most notably in poor-resource settings. However, recent literature asserts that CL constitutes a serious limitation to the full enjoyment of property rights by innovators and may therefore threaten drug accessibility in developing countries...
January 24, 2017: Applied Health Economics and Health Policy
https://www.readbyqxmd.com/read/28110486/spectra-optia-%C3%A2-for-automated-red-blood-cell-exchange-in-patients-with-sickle-cell-disease-a-nice-medical-technology-guidance
#10
REVIEW
Iain Willits, Helen Cole, Roseanne Jones, Kimberley Carter, Mick Arber, Michelle Jenks, Joyce Craig, Andrew Sims
The Spectra Optia(®) automated apheresis system, indicated for red blood cell exchange in people with sickle cell disease, underwent evaluation by the National Institute for Health and Care Excellence, which uses its Medical Technologies Advisory Committee to make recommendations. The company (Terumo Medical Corporation) produced a submission making a case for adoption of its technology, which was critiqued by the Newcastle and York external assessment centre. Thirty retrospective observational studies were identified in their clinical submission...
January 21, 2017: Applied Health Economics and Health Policy
https://www.readbyqxmd.com/read/28105555/malaria-and-economic-evaluation-methods-challenges-and-opportunities
#11
Tom L Drake, Yoel Lubell
There is a growing evidence base on the cost effectiveness of malaria interventions. However, certain characteristics of malaria decision problems present a challenge to the application of healthcare economic evaluation methods. This paper identifies five such challenges. The complexities of (i) declining incidence and cost effectiveness in the context of an elimination campaign; (ii) international aid and its effect on resource constraints; and (iii) supranational priority setting, all affect how health economists might use a cost-effectiveness threshold...
January 19, 2017: Applied Health Economics and Health Policy
https://www.readbyqxmd.com/read/28066863/assessing-equity-in-the-provision-of-primary-healthcare-centers-in-buenos-aires-province-argentina-a-stochastic-frontier-analysis
#12
Florencia Arnaudo, Fernando Lago, Valentina Viego
BACKGROUND: Unequal access to healthcare between individuals or populations does not imply the existence of inequities as it must be controlled for differences in need. This is usually done either via direct or indirect standardization methods. OBJECTIVE: We study the degree of equity in the availability of public primary healthcare centers between the 134 municipalities of the Buenos Aires province (Argentina) with a novel application of an existing statistical tool...
January 9, 2017: Applied Health Economics and Health Policy
https://www.readbyqxmd.com/read/28063135/cost-effectiveness-of-insulin-degludec-plus-liraglutide-ideglira-in-a-fixed-combination-for-uncontrolled-type-2-diabetes-mellitus-in-sweden
#13
Åsa Ericsson, Adam Lundqvist
BACKGROUND: Patients with uncontrolled type 2 diabetes mellitus (T2DM) are a priority group for intensified therapy without weight gain and with low risk of hypoglycaemia. OBJECTIVE: This study evaluates the cost effectiveness of insulin degludec plus liraglutide (IDegLira, Xultophy(®)) compared with six potential intensification treatment options for patients with T2DM that is uncontrolled with basal insulin. METHODS: The Swedish Institute for Health Economics (IHE) Cohort Model of Type 2 Diabetes was used with Swedish input data, a 40-year time frame and a societal perspective...
January 6, 2017: Applied Health Economics and Health Policy
https://www.readbyqxmd.com/read/28063134/how-can-pricing-and-reimbursement-policies-improve-affordable-access-to-medicines-lessons-learned-from-european-countries
#14
REVIEW
Sabine Vogler, Valérie Paris, Alessandra Ferrario, Veronika J Wirtz, Kees de Joncheere, Peter Schneider, Hanne Bak Pedersen, Guillaume Dedet, Zaheer-Ud-Din Babar
This article discusses pharmaceutical pricing and reimbursement policies in European countries with regard to their ability to ensure affordable access to medicines. A frequently applied pricing policy is external price referencing. While it provides some benchmark for policy-makers and has been shown to be able to generate savings, it may also contribute to delay in product launch in countries where medicine prices are low. Value-based pricing has been proposed as a policy that promotes access while rewarding useful innovation; however, implementing it has proven quite challenging...
January 6, 2017: Applied Health Economics and Health Policy
https://www.readbyqxmd.com/read/28035629/cost-effectiveness-of-different-population-screening-strategies-for-hereditary-haemochromatosis-in-australia
#15
Barbara de Graaff, Amanda Neil, Lei Si, Kwang Chien Yee, Kristy Sanderson, Lyle Gurrin, Andrew J Palmer
INTRODUCTION: Amongst populations of northern European ancestry, HFE-associated haemochromatosis is a common genetic disorder characterised by iron overload. In the absence of treatment, excess iron is stored in parenchymal tissues, causing morbidity and mortality. Population screening programmes may increase early diagnosis and reduce associated disease. No contemporary health economic evaluation has been published for Australia. The objective of this study was to identify cost-effective screening strategies for haemochromatosis in the Australian setting...
December 29, 2016: Applied Health Economics and Health Policy
https://www.readbyqxmd.com/read/27943165/assessment-of-public-health-and-economic-impact-of-intranasal-live-attenuated-influenza-vaccination-of-children-in-france-using-a-dynamic-transmission-model
#16
L Gerlier, M Lamotte, S Grenèche, X Lenne, F Carrat, C Weil-Olivier, O Damm, M Schwehm, M Eichner
OBJECTIVES: We estimated the epidemiological and economic impact of extending the French influenza vaccination programme from at-risk/elderly (≥65 years) only to healthy children (2-17 years). METHODS: A deterministic, age-structured, dynamic transmission model was used to simulate the transmission of influenza in the French population, using the current vaccination coverage with trivalent inactivated vaccine (TIV) in at-risk/elderly individuals (current strategy) or gradually extending the vaccination to healthy children (aged 2-17 years) with intranasal, quadrivalent live-attenuated influenza vaccine (QLAIV) from current uptake up to 50% (evaluated strategy)...
December 9, 2016: Applied Health Economics and Health Policy
https://www.readbyqxmd.com/read/27943164/sustaining-gains-in-health-programs-technical-efficiency-and-its-determinants-in-malaria-programs-in-sub-saharan-africa
#17
Esso-Hanam Atake
BACKGROUND: Since the year 2000, Africa has made significant progress in the fight against malaria. Between 2000 and 2015, the incidence and death from malaria fell by 42 and 66%, respectively. However, the African region still accounts for most global cases of malaria. In 2015, the region was home to 89% of malaria cases and 91% of malaria death. OBJECTIVE: This study aimed to evaluate efficiency of policies against malaria in 30 malaria-endemic Sub-Saharan African (SSA) countries, from the perspective of sustaining gains...
December 9, 2016: Applied Health Economics and Health Policy
https://www.readbyqxmd.com/read/27928660/economic-evaluation-of-community-based-case-management-of-patients-suffering-from-chronic-obstructive-pulmonary-disease
#18
Sabrina Storgaard Sørensen, Kjeld Møller Pedersen, Ulla Møller Weinreich, Lars Ehlers
OBJECTIVES: To analyse the cost effectiveness of community-based case management for patients suffering from chronic obstructive pulmonary disease (COPD). METHODS: The study took place in the third largest municipality in Denmark and was conducted as a randomised controlled trial with 12 months of follow-up. A total of 150 patients with COPD were randomised into two groups receiving usual care and case management in addition to usual care. Case management included among other things self care proficiency, medicine compliance, and care coordination...
December 7, 2016: Applied Health Economics and Health Policy
https://www.readbyqxmd.com/read/27928659/amplifying-each-patient-s-voice-a-systematic-review-of-multi-criteria-decision-analyses-involving-patients
#19
REVIEW
Kevin Marsh, J Jaime Caro, Alaa Hamed, Erica Zaiser
BACKGROUND: Qualitative methods tend to be used to incorporate patient preferences into healthcare decision making. However, for patient preferences to be given adequate consideration by decision makers they need to be quantified. Multi-criteria decision analysis (MCDA) is one way to quantify and capture the patient voice. The objective of this review was to report on existing MCDAs involving patients to support the future use of MCDA to capture the patient voice. METHODS: MEDLINE and EMBASE were searched in June 2014 for English-language papers with no date restriction...
December 7, 2016: Applied Health Economics and Health Policy
https://www.readbyqxmd.com/read/27896681/financial-impact-of-direct-acting-oral-anticoagulants-in-medicaid-budgetary-assessment-based-on-number-needed-to-treat
#20
Kathleen A Fairman, Lindsay E Davis, Courtney R Kruse, David A Sclar
BACKGROUND: Faced with rising healthcare costs, state Medicaid programs need short-term, easily calculated budgetary estimates for new drugs, accounting for medical cost offsets due to clinical advantages. OBJECTIVE: To estimate the budgetary impact of direct-acting oral anticoagulants (DOACs) compared with warfarin, an older, lower-cost vitamin K antagonist, on 12-month Medicaid expenditures for nonvalvular atrial fibrillation (NVAF) using number needed to treat (NNT)...
November 28, 2016: Applied Health Economics and Health Policy
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