Sebastien O Lanctôt, Leif Erik Lovblom, Evan J H Lewis, Michelle Morris, Nancy Cardinez, Daniel Scarr, Abdulmohsen Bakhsh, Mohammad I Abuabat, Julie A Lovshin, Yuliya Lytvyn, Geneviève Boulet, Alexandra Bussières, Michael H Brent, Narinder Paul, Vera Bril, David Z I Cherney, Bruce A Perkins
OBJECTIVE: Although insulin production is reportedly retained in many people with longstanding type 1 diabetes (T1D), the magnitude and relevance of connecting peptide (C-peptide) production are uncertain. In this study, we aimed to define fasted C-peptide distributions and associated clinical factors. METHODS: In a cross-sectional analysis of the Canadian Study of Longevity, fasted serum and urinary C-peptide was measured in 74 patients with longstanding T1D (duration ≥50 years) and 75 age- and sex-matched controls...
November 7, 2023: Canadian Journal of Diabetes