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Canadian Journal of Diabetes

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https://www.readbyqxmd.com/read/28139408/british-columbian-healthcare-providers-perspectives-on-facilitators-and-barriers-to-adhering-to-pediatric-diabetes-treatment-guidelines
#1
Bonnie McIntosh, Karine Khatchadourian, Shazhan Amed
OBJECTIVES: There are few studies exploring why adherence to clinical practice guidelines for the treatment of childhood type 1 diabetes is suboptimal. Our objective was to describe healthcare providers' perspectives on the facilitators of and barriers to adhering to pediatric diabetes treatment guidelines. METHODS: We fielded an electronic survey to 260 pediatric diabetes healthcare providers (physicians, nurses, dietitians) in British Columbia, Canada, followed by qualitative interviews with a purposeful sample (N=15) of physicians and allied healthcare providers...
January 27, 2017: Canadian Journal of Diabetes
https://www.readbyqxmd.com/read/28024794/does-resveratrol-improve-insulin-signalling-in-hepg2-cells
#2
Marjan Norouzzadeh, Fatemehsadat Amiri, Ali Akbar Saboor-Yaraghi, Farnoosh Shemirani, Yas Kalikias, Loghman Sharifi, Monireh Sadat Seyyedsalehi, Maryam Mahmoudi
OBJECTIVES: Diabetes mellitus is a common metabolic disorder with high global prevalence. It is characterized by a decrease in insulin secretion or a decrease in insulin sensitivity or both. The aim of the present study was to investigate the effects of resveratrol treatment on the expression of the genes involved in insulin signalling cascade, such as Forkhead box protein O1 (FoxO1), 3-phosphoinositide-dependent protein kinase 1 (PDPK1) and mammalian target of rapamycin (mTOR). METHODS: HepG2 cells were cultured in serum-free medium with high concentrations of glucose and insulin and then were treated with resveratrol (5, 10 and 20 µM) for 24 and 48 hours...
December 23, 2016: Canadian Journal of Diabetes
https://www.readbyqxmd.com/read/28024793/recombinant-interferon-alpha-2b-is-a-high-affinity-antigen-for-type-1-diabetes-autoantibodies
#3
Wahid Ali Khan
OBJECTIVES: Type 1 diabetes results from T-cell-mediated destruction of the beta cells of the pancreas and is associated with several autoimmune phenomena. Many studies have suggested the involvement of interferon alpha (IFN α) in the development of type 1 diabetes, but the exact mechanism remains unclear. In this study, the binding of type 1 diabetes antibodies with recombinant interferon alpha-2b (hrIFN α-2b), their gene (cIFN α-2b gene) and commercially available interferon α-2b (IFN α-2b) were assessed...
December 23, 2016: Canadian Journal of Diabetes
https://www.readbyqxmd.com/read/28017292/bullosis-diabeticorum-in-a-young-child-case-report-of-a-very-rare-entity-and-a-literature-review
#4
Anca Chiriac, Irina Costache, Cristian Podoleanu, Adrian Naznean, Simona Stolnicu
Bullosis diabeticorum (BD), or diabetic bulla, is 1 of the cutaneous manifestations of diabetes mellitus, reported in 0.5% of people with diabeties in the United States, mostly in adult men who have had long-lasting and uncontrolled diabetes associated with diabetic peripheral neuropathy. However, BD in young children is a mostly unrecognized entity. We present a case of BD in a 3-year-old girl with type 1 diabetes mellitus who had been treated with insulin for 7 months prior to hospitalization. Dermatologic examination revealed a large, tense bulla filled with clear fluid and not associated with pain or pruritus, localized on the lateral margin of the right hand...
December 21, 2016: Canadian Journal of Diabetes
https://www.readbyqxmd.com/read/28007351/evaluation-of-a-computerized-self-management-tool-for-children-with-type-1-diabetes-a-pilot-project
#5
Navita Dyal, Karen McAssey, Gina Agarwal
No abstract text is available yet for this article.
December 20, 2016: Canadian Journal of Diabetes
https://www.readbyqxmd.com/read/27989495/assessing-whether-the-association-between-sleep-apnea-and-diabetes-is-bidirectional
#6
Chia-Lin Liu, Chi-Shin Wu
OBJECTIVES: To determine whether there is a bidirectional association between sleep apnea and diabetes mellitus. METHODS: We conducted longitudinal analyses of a population-based cohort over 12 years using Taiwan's national universal health insurance database. In analysis I, we included 102 355 individuals without type 2 diabetes mellitus at baseline and estimated the hazard ratio of incident diagnosis of type 2 diabetes mellitus for patients with and those without sleep apnea...
December 15, 2016: Canadian Journal of Diabetes
https://www.readbyqxmd.com/read/27989494/self-monitoring-of-blood-glucose-impact-of-quantity-limits-in-public-drug-formularies-on-provincial-costs-across-canada
#7
Sandra R Knowles, Kathy Lee, J Michael Paterson, Baiju R Shah, Muhammad M Mamdani, David N Juurlink, Tara Gomes
OBJECTIVES: For most patients with diabetes, routine use of blood glucose test strips (BGTS) has not been shown to be beneficial, yet the economic implications of broad publicly funded reimbursement for BGTS are substantial. We assessed the potential impact of BGTS quantity limits on utilization and costs for 6 publicly funded drug plans across Canada. METHODS: A cross-sectional analysis was conducted in 6 provinces (Alberta, Saskatchewan, Manitoba, Nova Scotia, Newfoundland and Labrador and Prince Edward Island) for patients who received at least 1 prescription for BGTS in 2014 through the public drug program...
December 15, 2016: Canadian Journal of Diabetes
https://www.readbyqxmd.com/read/27939876/strategies-used-by-patients-with-type-1-diabetes-to-avoid-hypoglycemia-in-a-24%C3%A3-1-hour-marathon-comparison-with-the-amounts-of-carbohydrates-estimated-by-a-customizable-algorithm
#8
Alex Buoite Stella, Roberta Assaloni, Laura Tonutti, Elena Manca, Carla Tortul, Riccardo Candido, Maria Pia Francescato
OBJECTIVES: The preferred countermeasure to avoid exercise-related hypoglycemia was investigated in a group of patients with type 1 diabetes participating in a stressful event, a 24×1-hour relay marathon. The carbohydrates actually consumed were compared to those estimated for each patient by applying a customizable algorithm, Exercise Carbohydrates Requirement Estimating Software (ECRES), based on patient's usual therapy and diet and on the exercise characteristics. METHODS: Glycemia was tested at the start, middle and end of the races...
December 8, 2016: Canadian Journal of Diabetes
https://www.readbyqxmd.com/read/27913110/downregulated-brain-derived-neurotrophic-factor-induced-oxidative-stress-in-the-pathophysiology-of-diabetic-retinopathy
#9
REVIEW
Tapan Behl, Anita Kotwani
Brain-derived neurotrophic factor (BDNF), a member of neurotrophin growth factor family, physiologically mediates induction of neurogenesis and neuronal differentiation, promotes neuronal growth and survival and maintains synaptic plasticity and neuronal interconnections. Unlike the central nervous system, its secretion in the peripheral nervous system occurs in an activity-dependent manner. BDNF improves neuronal mortality, growth, differentiation and maintenance. It also provides neuroprotection against several noxious stimuli, thereby preventing neuronal damage during pathologic conditions...
November 29, 2016: Canadian Journal of Diabetes
https://www.readbyqxmd.com/read/27908559/influence-of-a-pay-for-performance-program-on-glycemic-control-in-patients-living-with-diabetes-by-family-physicians-in-a-canadian-province
#10
Emilie LeBlanc, Mathieu Bélanger, Véronique Thibault, Lise Babin, Beverly Greene, Stuart Halpine, Michelina Mancuso
OBJECTIVES: We evaluated the influence of the introduction of a pay-for-performance program implemented in 2010 for family physicians on the glycemic control of patients with diabetes. METHODS: Administrative data for all 583 eligible family physicians and 83,580 adult patients with diabetes in New Brunswick over 10 years were used. We compared the probability of receiving at least 2 tests for glycated hemoglobin (A1C) levels and achieving glycemic control before (2005-2009) and after (2010-2014) the implementation of the program and between patients divided based on whether a physician claimed the incentive or did not...
November 29, 2016: Canadian Journal of Diabetes
https://www.readbyqxmd.com/read/27908558/time-varying-risk-for-breast-cancer-following-initiation-of-glucose-lowering-therapy-in-women-with-type-2-diabetes-exploring-detection-bias
#11
Samantha L Bowker, Mu Lin, Dean T Eurich, Jeffrey A Johnson
OBJECTIVES: To explore detection bias in the association between glucose-lowering therapies and breast cancer in a cohort of women with type 2 diabetes. METHODS: This was a retrospective, population-based cohort study. We identified new users of metformin, sulfonylureas, thiazolidinediones and insulin during the index period of January 1, 2003, to December 31, 2010. The main outcome was incident breast cancer, and patients were followed up from drug exposure index date until death, diagnosis of another type of cancer, termination of medical insurance or December 31, 2010...
November 29, 2016: Canadian Journal of Diabetes
https://www.readbyqxmd.com/read/28126155/social-media-as-a-platform-for-information-about-diabetes-foot-care-a-study-of-facebook-groups
#12
Tasnima Abedin, Mohammad Al Mamun, Mohammad A A Lasker, Syed Walid Ahmed, Nusrat Shommu, Nahid Rumana, Tanvir C Turin
BACKGROUND: Diabetes is one of the most challenging chronic health conditions in the current era. Diabetes-related foot problems need proper patient education, and social media could a play role to disseminate proper information. METHOD: A systematic search was performed on Facebook groups using the key words "diabetes foot care", "diabetes foot", "diabetes foot management" and "podiatric care". The search resulted in 57 groups and detailed activity information was collected from those groups...
February 2017: Canadian Journal of Diabetes
https://www.readbyqxmd.com/read/28126154/erratum-to-oral-presentation-abstracts-canadian-journal-of-diabetes-volume-40-2016-page-s15
#13
Margaret L Lawson, Allyson L Shephard, Bryan Feenstra, Laura Boland, Nadia Sourial, Dawn Stacey
No abstract text is available yet for this article.
February 2017: Canadian Journal of Diabetes
https://www.readbyqxmd.com/read/27916497/the-diabeates-project-perceptual-affective-and-psychophysiological-effects-of-music-and-music-video-in-a-clinical-exercise-setting
#14
Jasmin C Hutchinson, Costas I Karageorghis, Jessica D Black
OBJECTIVES: The purpose of this study was to examine the effects of music and music-video on perceptual (attentional focus, rated perceived exertion), affective (affective valence and enjoyment) and psychophysiological (blood glucose, heart rate) variables in outpatients attending a diabetes exercise clinic. METHODS: Participants were 24 females (age = 66.0 ± 8.5 years) enrolled in a supervised exercise program for people with diabetes. They engaged in mixed-modality exercise sessions that included a standardized combination of flexibility, aerobic and resistance activities under conditions of music, music-video and control...
February 2017: Canadian Journal of Diabetes
https://www.readbyqxmd.com/read/27916496/hyperlipidemia-mediated-increased-advanced-lipoxidation-end-products-formation-an-important-factor-associated-with-decreased-erythrocyte-glucose-6-phosphate-dehydrogenase-activity-in-mild-nonproliferative-diabetic-retinopathy
#15
Subhadip Choudhuri, Pijush Kanti Roy, Bhaskar Mitra, Susruta Sen, Rajarshi Sarkar, Mandrita Das, Debashree Biswas, Prithwijit Ghosh, Ajoy Biswas, Shaibal Chakraborty, Lakshmi Kanta Mondal
OBJECTIVES: The present study aimed to evaluate the role of hyperlipidemia in increased formation of advanced lipoxidation end products (ALEs) and to evaluate whether there is any relationship between ALEs generation and erythrocyte glucose-6-phosphate dehydrogenase (G6PD) activity in cases of mild nonproliferative diabetic retinopathy (MNPDR). METHODS: In this study, we enrolled 100 patients with type 2 diabetes and MNPDR, 100 subjects with type 2 diabetes but without retinopathy (DNR) and 90 normal individuals without diabetes as healthy controls (HCs)...
February 2017: Canadian Journal of Diabetes
https://www.readbyqxmd.com/read/27838228/can-the-combination-of-incretin-agents-and-sodium-glucose-cotransporter-2-sglt2-inhibitors-reconcile-the-yin-and-yang-of-glucagon
#16
REVIEW
Ronald M Goldenberg, Subodh Verma, Bruce A Perkins, Jeremy D Gilbert, Bernard Zinman
No abstract text is available yet for this article.
February 2017: Canadian Journal of Diabetes
https://www.readbyqxmd.com/read/27789111/the-relationship-between-diabetes-care-quality-and-diabetes-related-hospitalizations-and-the-modifying-role-of-comorbidity
#17
Yelena Petrosyan, Yu Qing Bai, Anna J Koné Pefoyo, Andrea Gruneir, Kednapa Thavorn, Colleen J Maxwell, Susan E Bronskill, Walter P Wodchis
OBJECTIVES: To evaluate the impact of comorbidity on diabetes care quality and diabetes-related hospitalizations and to examine whether associations between the likelihood of diabetes-related hospitalizations and compliance with diabetes testing are modified by type of comorbidity. METHODS: A population-based cohort study of 861 354 adults with diabetes was conducted in Ontario, Canada. The diabetes cohort was categorized into 4 groups defined by their comorbidity statuses: no comorbidity, diabetes-concordant only, diabetes-discordant only, and both concordant and discordant...
February 2017: Canadian Journal of Diabetes
https://www.readbyqxmd.com/read/27745846/diabetes-distress-and-depression-in-south-asian-canadians-with-type-2-diabetes
#18
Rawel Sidhu, Tricia S Tang
OBJECTIVES: South Asians are disproportionately affected by diabetes compared to some other ethnic groups in Canada. Although depression and diabetes distress are psychological issues well studied in the general population of those with diabetes, they have not been investigated in South Asian Canadians with type 2 diabetes. We sought to identify the rates of depression and diabetes distress in South Asian adults with type 2 diabetes and to explore the relationship among glycemic control, depression and diabetes distress...
February 2017: Canadian Journal of Diabetes
https://www.readbyqxmd.com/read/27727090/impact-of-the-balanced-school-day-on-glycemic-control-in-children-with-type-1-diabetes
#19
Robert I Stein, Manpreet Doulla, Jamie A Seabrook, Lorraine Yau, Natasha Hamilton, Marina I Salvadori, Paula D N Dworatzek
OBJECTIVE: The balanced school day (BSD) is an alternative elementary school schedule whereby children have 2 20-minute eating periods instead of 1 20-minute lunch, as is found in the traditional schedule (TS). We assessed the glycated hemoglobin (A1C) levels of children with type 1 diabetes in the TS vs. the BSD because 2 eating periods have the potential to impact blood glucose control. METHODS: A1C levels representative of the summer months (SumA1C) and A1C levels occurring at least 3 months after the start of the school year (SchA1C) were obtained retrospectively...
February 2017: Canadian Journal of Diabetes
https://www.readbyqxmd.com/read/27697449/a-longitudinal-investigation-of-anxiety-and-depressive-symptomatology-and-exercise-behaviour-among-adults-with-type-2-diabetes-mellitus
#20
Elena Ivanova, Rachel J Burns, Sonya S Deschênes, Bärbel Knäuper, Norbert Schmitz
OBJECTIVES: Evidence suggests that symptoms of depression and anxiety predict lower exercise behaviour and, inversely, that less exercise predicts higher symptomatology. The present longitudinal study examined this reciprocal association in adults with type 2 diabetes mellitus. We predicted that symptoms of anxiety or depression would intensify over time as a consequence of lower exercise frequency and, similarly, that exercise frequency would decrease as a consequence of greater symptoms of anxiety or depression...
February 2017: Canadian Journal of Diabetes
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