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Canadian Journal of Diabetes

Rawel Sidhu, Tricia S Tang
OBJECTIVES: South Asians are disproportionately affected by diabetes compared to some other ethnic groups in Canada. Although depression and diabetes distress are psychological issues well studied in the general population of those with diabetes, they have not been investigated in South Asian Canadians with type 2 diabetes. We sought to identify the rates of depression and diabetes distress in South Asian adults with type 2 diabetes and to explore the relationship among glycemic control, depression and diabetes distress...
October 10, 2016: Canadian Journal of Diabetes
Robert I Stein, Manpreet Doulla, Jamie A Seabrook, Lorraine Yau, Natasha Hamilton, Marina I Salvadori, Paula D N Dworatzek
OBJECTIVE: The balanced school day (BSD) is an alternative elementary school schedule whereby children have 2 20-minute eating periods instead of 1 20-minute lunch, as is found in the traditional schedule (TS). We assessed the glycated hemoglobin (A1C) levels of children with type 1 diabetes in the TS vs. the BSD because 2 eating periods have the potential to impact blood glucose control. METHODS: A1C levels representative of the summer months (SumA1C) and A1C levels occurring at least 3 months after the start of the school year (SchA1C) were obtained retrospectively...
October 7, 2016: Canadian Journal of Diabetes
Elena Ivanova, Rachel J Burns, Sonya S Deschênes, Bärbel Knäuper, Norbert Schmitz
OBJECTIVES: Evidence suggests that symptoms of depression and anxiety predict lower exercise behaviour and, inversely, that less exercise predicts higher symptomatology. The present longitudinal study examined this reciprocal association in adults with type 2 diabetes mellitus. We predicted that symptoms of anxiety or depression would intensify over time as a consequence of lower exercise frequency and, similarly, that exercise frequency would decrease as a consequence of greater symptoms of anxiety or depression...
September 30, 2016: Canadian Journal of Diabetes
Danielle M Thiel, Fatima Al Sayah, Jeff K Vallance, Steven T Johnson, Jeffrey A Johnson
OBJECTIVES: To examine the association between meeting physical-activity recommendations and health-related quality of life (HRQL) in adults with type 2 diabetes. METHODS: Data from the Alberta's Caring for Diabetes cohort were used. Self-report questionnaires were mailed to patients with type 2 diabetes who were living in Alberta, Canada. Weekly moderate-vigorous physical activity (MVPA) was reported using the Godin Leisure Time Physical Activity Questionnaire, and HRQL was reported using the Medical Outcomes Study (MOS) 12-Item Short-Form Health Survey v...
September 28, 2016: Canadian Journal of Diabetes
Benjamin Markowitz, Janet A Parsons, Andrew Advani
No abstract text is available yet for this article.
September 19, 2016: Canadian Journal of Diabetes
Suqing Li, Sylvia Roschkov, Blair J O'Neill, Constance L Chik, Ross T Tsuyuki, Gabor T Gyenes
OBJECTIVE: To determine the benefits of diabetes nurse practitioner (DNP) intervention on glycemic control, quality of life and diabetes treatment satisfaction in patients with type 2 diabetes (T2DM) admitted to cardiology inpatient services at a tertiary center. PATIENTS AND METHODS: Patients admitted to the cardiology service with T2DM who had sub-optimal control (HbA1c >6.5%) were approached for the study. Diabetes care was optimized by the DNP through medication review, patient education and discharge care-planning...
September 19, 2016: Canadian Journal of Diabetes
Rebecca C Nolan, Annette J Raynor, Narelle M Berry, Esther J May
OBJECTIVES: The aim of this study was to survey the level of self-reported physical activity in people with type 2 diabetes, with and without peripheral neuropathy. METHODS: A sample of South Australian adults (n=481) 33 to 88 years of age who had type 2 diabetes, including 55 people with peripheral neuropathy, completed the International Physical Activity Questionnaire (IPAQ). Levels of self-reported physical activity were compared between those with and without peripheral neuropathy...
September 19, 2016: Canadian Journal of Diabetes
Ivana Roth-Albin, Safiah H C Mai, Zeeshan Ahmed, Ji Cheng, Karen Choong, Perry V Mayer
OBJECTIVES: Data concerning outcomes of Canadian patients with diabetic foot ulcers (DFUs) are limited. The objectives of this study were to evaluate the healing rates and identify the predictors of poor outcomes following advanced wound care in patients presenting with DFUs. METHODS: We conducted retrospective cohort study of adult patients who had DFUs and were referred to a single Canadian advanced diabetic foot and wound care centre between January 1, 2010, and December 31, 2010...
September 12, 2016: Canadian Journal of Diabetes
Amanda J Brahm, Grace Wang, Jian Wang, Adam D McIntyre, Henian Cao, Matthew R Ban, Robert A Hegele
OBJECTIVES: Maturity-onset diabetes of the young (MODY) is the most common form of monogenic diabetes, reportedly accounting for 2% to 5% of all cases of diabetes. In samples from Canadian patients referred for molecular genetic confirmation of a clinically suspected MODY, we determined the prevalence of likely disease-causing DNA variants in known MODY genes. METHODS: Between 1999 and 2015, our centre received requests from colleagues for DNA sequencing of 96 samples from unrelated Canadian patients with clinically suspected MODY...
September 12, 2016: Canadian Journal of Diabetes
Barry I Posner
Insulin signalling begins with binding to its cell surface insulin receptor (IR), which is a tyrosine kinase. The insulin receptor kinase (IRK) is subsequently autophosphorylated and activated to tyrosine phosphorylate key cellular substrates that are essential for entraining the insulin response. Although IRK activation begins at the cell surface, it is maintained and augmented following internalization into the endosomal system (ENS). The peroxovanadium compounds (pVs) were discovered to activate the IRK in the absence of insulin and lead to a full insulin response...
September 7, 2016: Canadian Journal of Diabetes
Cynthia Gagnon, Annie Aimé, Claude Bélanger
OBJECTIVES: The objective of this study was to identify psychosocial predictors of comorbid eating disorders (EDs) in individuals with type 1 and type 2 diabetes. METHODS: In this cross-sectional study, 140 people with diabetes answered an online survey covering sociodemographic information, body esteem, restrictive eating, medication omission, coping styles and depressive symptoms. Participants were recruited through advertisements on more than 100 websites, including forums, community organizations and Facebook groups focusing on either diabetes or EDs...
September 7, 2016: Canadian Journal of Diabetes
Jun Li, Matteo Cesari, Fei Liu, Birong Dong, Bruno Vellas
Basic and clinical research support a link between diabetes mellitus and Alzheimer disease (AD). However, the relationship with AD progression is unclear. This review focuses on the association between diabetes and cognitive decline in patients with AD. The literature published through May 2015 was searched in 3 databases: PubMed, Embase and Cochrane. Studies evaluating the effects of diabetes on patients with AD or cognitive decline were included, and extracted data were analyzed. A total of 10 articles met the inclusion criteria for review...
September 7, 2016: Canadian Journal of Diabetes
Emayavaramban Priyadarshini, Carani Venkatraman Anuradha
OBJECTIVES: High intake of dietary fructose causes perturbation in lipid metabolism and provokes lipid-induced insulin resistance. A rise in glucocorticoids (GCs) has recently been suggested to be involved in fructose-induced insulin resistance. The objective of the study was to investigate the effect of GC blockade on lipid abnormalities in insulin-resistant mice. METHODS: Insulin resistance was induced in mice by administering a high-fructose diet (HFrD) for 60 days...
September 7, 2016: Canadian Journal of Diabetes
Chelsea Smallwood, Danièle Lamarche, Annie Chevrier
Insulin administration in the acute care setting is an integral component of inpatient diabetes management. Although some institutions have moved to insulin pen devices, many acute care settings continue to employ the vial and syringe method of insulin administration. The aim of this study was to evaluate the impact of insulin pen implementation in the acute care setting on patients, healthcare workers and health resource utilization. A review of published literature, including guidelines, was conducted to identify how insulin pen devices in the acute care setting may impact inpatient diabetes management...
September 2, 2016: Canadian Journal of Diabetes
Dimitrios Agapakis, Christos Savopoulos, Kyriakos E Kypreos, Emma Gbandi, Stavros Iliadis, Apostolos I Hatzitolios, Antonis Goulas
OBJECTIVE: To examine the association of 2 common polymorphisms in high-density lipoprotein (HDL)-related genes, namely, cholesterol ester transfer protein CETP Taq1B (rs708272) and endothelial lipase LIPG Thr111Ile (rs2000813), with glycated hemoglobin (A1C), blood lipid levels and the risk for type 2 diabetes in a group of hyperlipidemic patients from northern Greece. METHODS: We categorized 175 patients with hyperlipidemia into 2 subgroups according to the presence or absence of type 2 diabetes, defined as a recent diagnosis, A1C >6...
August 30, 2016: Canadian Journal of Diabetes
Paul E Alexander, Shelly-Anne Li, Marcello Tonelli, Gordon Guyatt
OBJECTIVES: The Canadian Task Force on Preventive Health Care (CTFPHC) produces guidelines for Canadian physicians regarding screening and prevention. To better appreciate the barriers to and facilitators of guideline adherence, we sought to explore physicians' views of guidelines in general and their understanding of this CTFPHC diabetes screening guideline in particular because they pertain to screening and positive treatment. METHODS: We included Canadian physicians (N=10) who agreed to be interviewed regarding their use of guidelines as part of practice, focusing on the CTFPHC 2012 diabetes screening guideline...
August 30, 2016: Canadian Journal of Diabetes
Edmond A Ryan, Joanna Holland, Eleni Stroulia, Blerina Bazelli, Stephanie A Babwik, Haipeng Li, Peter Senior, Russ Greiner
OBJECTIVES: Smartphones are a potentially useful tool in diabetes care. We have developed an application (app) linked to a website, Intelligent Diabetes Management (IDM), which serves as both an insulin bolus calculator and an electronic diabetes diary. We have prospectively studied whether patients using this app improved control of their glucose levels. METHODS: Patients with type 1 diabetes were recruited. There was a 4-week observation period, midway during which we offered to review the participants' records...
August 25, 2016: Canadian Journal of Diabetes
Sonia Butalia, Gilaad G Kaplan, Bushra Khokhar, Doreen M Rabi
Type 1 diabetes is an autoimmune condition that results from the destruction of the insulin-producing beta cells of the pancreas. The excess morbidity and mortality resulting from its complications, coupled with its increasing incidence, emphasize the importance of better understanding the causes of this condition. Over the past several decades, a substantive amount of work has been done and, although many advances have occurred in identifying disease-susceptibility genes, there has been a lag in understanding the environmental triggers...
August 18, 2016: Canadian Journal of Diabetes
Marzie Zilaee, Saeed Shirali
Diabetes is a chronic disease, and its prevalence continues to rise and can increase the risk for the progression of microvascular (such as nephropathy, retinopathy and neuropathy) and also macrovascular complications. Diabetes is a condition in which the oxidative stress and inflammation rise. Heat shock proteins (HSPs) are a highly conserved family of proteins that are expressed by all cells exposed to environmental stress, and they have diverse functions. In patients with diabetes, the expression and levels of HSPs decrease, but these chaperones can aid in improving some complications of diabetes, such as oxidative stress and inflammation...
August 18, 2016: Canadian Journal of Diabetes
Peter A Hall, Nadira Husein, Corita Vincent
No abstract text is available yet for this article.
August 17, 2016: Canadian Journal of Diabetes
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