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Canadian Journal of Diabetes

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https://www.readbyqxmd.com/read/28647295/associations-between-sleep-habits-and-dysglycemia-in-us-adults-a-cross-sectional-analysis
#1
Katherina C Chojnacki, Thirumagal Kanagasabai, Michael C Riddell, Chris I Ardern
OBJECTIVES: To examine the independent and joint associations between sleep duration and quality with glycated hemoglobin (A1C) levels and dysglycemia in non-institutionalized adults living in the United States. METHODS: Data from the United States National Health and Nutrition Examination Survey (2005-2008) were used (N=9478; ≥20 years). Information on sleep quantity and quality were derived from the Sleep Disorders Questionnaire and used to classify sleep quality as good, fair, poor, or very poor...
June 21, 2017: Canadian Journal of Diabetes
https://www.readbyqxmd.com/read/28642056/can-stem-cells-ameliorate-the-pancreatic-damage-induced-by-streptozotocin-in-rats
#2
Amira Ragab El Barky, Amany Abdel Hamid Ezz, Abeer Abd-Elhameed Alm-Eldeen, Samy Ali Hussein, Yehia Ahmed Hafez, Tarek Mostafa Mohamed
BACKGROUND: Stem cell therapy holds great promise for the repair of injured tissues and organs, and it is one of the most promising therapies for diabetes mellitus. Therefore, the present study was undertaken to elucidate the antidiabetic effect of both mesenchymal stem cells (MSCs) and insulin-producing cells (IPCs) on streptozotocin (STZ)-induced diabetes in rats. MATERIALS AND METHODS: MSCs were derived from bone marrow of male albino rats. MSCs were characterized morphologically and by Cluster of differentiation (CD(-ve34)) and (CD(+ve105))...
June 19, 2017: Canadian Journal of Diabetes
https://www.readbyqxmd.com/read/28623081/multimorbidity-a-review-of-the-complexity-of-mental-health-issues-in-bariatric-surgery-candidates-informed-by-canadian-data
#3
REVIEW
Valerie H Taylor, Jennifer Hensel
BACKGROUND: Multimorbidity is significant for obesity and mental health issues. As a consequence, mental illness is overrepresented in patients seeking bariatric surgery. This review addresses that overlap, with a focus on Canadian data. CONCLUSION: The healthcare system in Canada is unique, but issues related to prevalence of mental health in patients seeking bariatric surgery are similar to those in studies conducted in other countries. Although data on suicide are lacking, Canadian data have shown similar rates of self-harm behaviours and linkages between psychopathology and weight regain after surgery...
June 13, 2017: Canadian Journal of Diabetes
https://www.readbyqxmd.com/read/28600119/effects-on-diabetes-medications-weight-and-a1c-among-patients-with-obesity-and-diabetes-6-month-observations-from-a-full-meal-replacement-low-calorie-diet-weight-management-program
#4
Judy Y Shiau, Derek Y F So, Robert R Dent
OBJECTIVES: A 6-month weight-management program with full meal replacement, low-calorie diet (full MR-LCD) (900 kcal/day for 6 to 12 weeks) follows a protocol for patients with diabetes for decreasing or discontinuing weight-gaining diabetes medications first (Group WG) and then titrating weight-neutral medications (Group WN). METHODS: This is a retrospective cohort study (1992 to 2009) of weight, glycemic control and diabetes medications changes in 317 patients with obesity and type 2 diabetes who were taking medications...
June 6, 2017: Canadian Journal of Diabetes
https://www.readbyqxmd.com/read/28600118/so-many-antihyperglycemics-how-to-choose-a-practical-approach
#5
Alice Y Y Cheng
Guidelines from around the world have stressed the importance of glycemic control in the management of patients with type 2 diabetes (T2DM) to reduce the risk of developing complications. To achieve this goal, both lifestyle and pharmacologic therapies are available. There are 9 classes of antihyperglycemic therapies available in Canada and each class provides a different mechanism of action to address the pathophysiology of T2DM. Metformin remains the first choice for pharmacologic therapy. Thereafter, individualization is essential...
June 6, 2017: Canadian Journal of Diabetes
https://www.readbyqxmd.com/read/28583472/prenatal-obstetric-and-perinatal-factors-associated-with-the-development-of-childhood-onset-type-2-diabetes
#6
Julie Halipchuk, Beverley Temple, Allison Dart, Donna Martin, Elizabeth A C Sellers
OBJECTIVE: To explore associations among prenatal, obstetric and perinatal factors and the development of childhood-onset type 2 diabetes. METHODS: This retrospective, case-control study utilized administrative data housed at the Manitoba Centre for Health Policy. De-identified health records were examined from a sample of 270 children (aged 10 to 17 years at time of diagnosis) with type 2 diabetes and 1341 children without type 2 diabetes matched for age, sex and geographic location...
June 2, 2017: Canadian Journal of Diabetes
https://www.readbyqxmd.com/read/28583471/expression-of-glucose-transporter-proteins-in-human-diabetic-placenta
#7
REVIEW
Paweł Jan Stanirowski, Dariusz Szukiewicz, Monika Pazura-Turowska, Włodzimierz Sawicki, Krzysztof Cendrowski
Gestational diabetes mellitus and pregestational diabetes mellitus constitute carbohydrate metabolism disorders, which, if not diagnosed and adequately treated, lead to serious and often life-threatening pregnancy complications. According to a recently formulated hypothesis, some diabetes-related complications, such as fetal macrosomia, may be the result of disturbances in the transplacental transport of nutrients-in particular, excessive maternal-fetal glucose transfer. Throughout pregnancy, glucose flux across the placenta is mediated by the group of facilitative glucose transporters (GLUT), the expression of which in different placental compartments is the precondition for effective glucose uptake from maternal blood and its subsequent transfer to the fetal circulation...
June 2, 2017: Canadian Journal of Diabetes
https://www.readbyqxmd.com/read/28583470/insights-into-the-current-management-of-older-adults-with-type-2-diabetes-in-the-ontario-primary-care-setting
#8
Graydon S Meneilly, Lori D Berard, Alice Y Y Cheng, Peter J Lin, Lori MacCallum, Ross T Tsuyuki, Jean-François Yale, Nahal Nasseri, Jean-François Richard, Lianne Goldin, Anatoly Langer, Mary K Tan, Lawrence A Leiter
OBJECTIVE: The Goal Oriented controL of Diabetes in the Elderly populatioN (GOLDEN) Program assessed the management of older persons with type 2 diabetes in Canadian primary care. METHODS: Data were extracted from the records of 833 consecutively identified persons 65 years of age or older who had type 2 diabetes and were taking 1 antihyperglycemic agent or more; they were managed by 64 physicians from 36 Ontario clinics. RESULTS: More than half (53%) had glycated hemoglobin (A1C) levels of 7...
June 2, 2017: Canadian Journal of Diabetes
https://www.readbyqxmd.com/read/28579199/comorbid-conditions-in-canadians-hospitalized-because-of-diabetes
#9
REVIEW
Andreas Wielgosz, Sulan Dai, Peter Walsh, Jennifer McCrea-Logie, Ece Celebican
OBJECTIVES: The number of hospital discharges involving type 1 or type 2 diabetes as the first-listed diagnosis has increased over the past few decades. Such cases are commonly associated with various comorbidities. We analyzed data collected from hospital separations in Canada to determine the number and proportion of comorbid conditions in Canadians hospitalized because of diabetes. METHODS: The most responsible diagnosis (MRDx) of diabetes (ICD-10-CA: E10 [type 1 diabetes] or E11 [type 2 diabetes]) was identified from acute care hospital separations (Discharge Abstract Database) from 2013 to 2014 in all Canadian jurisdictions except Quebec...
May 31, 2017: Canadian Journal of Diabetes
https://www.readbyqxmd.com/read/28579198/considerations-for-initiating-a-sodium-glucose-co-transporter-2-inhibitor-in-individuals-with-type-2-diabetes-using-insulin
#10
REVIEW
Vincent C Woo, Lori D Berard, Harpreet S Bajaj, Jean-Marie Ekoé, Peter A Senior
In order to meet and maintain glycemic control, pharmacological management of individuals with type 2 diabetes typically begins with metformin followed by the introduction of other oral antihyperglycemic agents as needed. In some patients, the aggressive and progressive degeneration of pancreatic β cell activity means insulin therapy will become a given. The need to routinely monitor blood glucose levels coupled with the undesirable effects associated with insulin-primarily hypoglycemia and weight gain-commonly contribute to physician and patient inertia...
May 31, 2017: Canadian Journal of Diabetes
https://www.readbyqxmd.com/read/28552652/blood-pressure-management-in-patients-with-diabetes-insights-from-the-diabetes-mellitus-status-in-canada-survey
#11
Jasmine Grenier, Shaun G Goodman, Lawrence A Leiter, Anatoly Langer, Hwee Teoh, Deepak L Bhatt, Alice Y Y Cheng, Mary K Tan, Thomas Ransom, Kim A Connelly, Andrew T Yan
OBJECTIVES: Optimal treatment of blood pressure (BP) and other cardiovascular risk factors, including hyperglycemia, is integral to diabetes management. There are limited data from the primary care setting concerning the contemporary and comprehensive management of type 2 diabetes and other cardiovascular risk factors in relation to guideline-recommended BP target achievement. METHODS: The Diabetes Mellitus Status in Canada (DM-SCAN) survey included 5172 ambulatory patients with type 2 diabetes...
May 25, 2017: Canadian Journal of Diabetes
https://www.readbyqxmd.com/read/28552651/the-gut-microbiota-as-a-mediator-of-metabolic-benefits-after-bariatric-surgery
#12
REVIEW
Fernando F Anhê, Thibault V Varin, Jonathan D Schertzer, André Marette
Bariatric surgery is based on major anatomic rearrangements in the gastrointestinal tract that coincide with functional and taxonomic changes in gut microbial communities. These alterations in gut anatomy and in the microbiota are associated with early resolution of obesity-related impairment of glycemic control and are marked weight loss in the long term. Moreover, altered bile acid metabolism has been implicated in the control of energy homeostasis, emerging as a pivotal orchestrator in the gut microbiota-mediated effects of bariatric surgery...
May 25, 2017: Canadian Journal of Diabetes
https://www.readbyqxmd.com/read/28551162/association-of-sympathovagal-imbalance-with-cognitive-impairment-in-type-2-diabetes
#13
Pal Auroprajna, Basanta Manjari Naik, Jaya Prakash Sahoo, Gorantla Shravya Keerthi, Manohar Pavanya, Gopal Krushna Pal
OBJECTIVE: Sympathovagal imbalance (SVI) has been reported to be associated with metabolic derangements in type 2 diabetes. We investigated the association of SVI with cognitive impairment in patients with type 2 diabetes. METHODS: Patients with a new diagnosis of type 2 diabetes (n=43) and age-matched healthy control subjects (n=43) were recruited for the study. Body mass index and blood pressure measurements were recorded. SVI was assessed by spectral analysis of heart rate variability (HRV), and cognitive function was assessed by recording the positive wave that appears in 300 milliseconds from application of stimulus in event-related potential tracing (P300)...
May 24, 2017: Canadian Journal of Diabetes
https://www.readbyqxmd.com/read/28549669/the-iscreen-electronic-diabetes-dashboard-a-tool-to-improve-knowledge-and-implementation-of-clinical-practice-guidelines
#14
Stacy Zahanova, Alexandra Tsouka, Mark R Palmert, Farid H Mahmud
OBJECTIVES: Clinical practice guidelines (CPG) provide evidence-based recommendations for patient care but may not be optimally applied in clinical settings. As a pilot study, we evaluated the impact of a computerized, point-of-care decision support system (CDSS) on guideline knowledge and adherence in our diabetes clinic. METHODS: iSCREEN, a CDSS, integrated with a province-wide electronic health record, was designed based on the Canadian Diabetes Association 2013 Clinical Practice Guidelines for the Prevention and Management of Diabetes in Canada...
May 23, 2017: Canadian Journal of Diabetes
https://www.readbyqxmd.com/read/28549668/patient-perspectives-on-diabetes-care-across-the-institute-of-medicine-s-six-domains-of-quality
#15
I J Halperin, G Mukerji, M Maione, P Segal, M Wolfs, J Goguen, L Jeffs
OBJECTIVES: To gather patient perspectives on quality of care provided in diabetes clinics within the framework of the Institute of Medicine's 6 domains of quality. METHODS: A qualitative study including semi-structured interviews was conducted at 5 academic hospital sites. Transcripts were analyzed using a direct content approach for themes and subthemes with saturation of themes achieved. Purposive sampling was conducted at 5 diabetes clinics (n=47 interviews)...
May 23, 2017: Canadian Journal of Diabetes
https://www.readbyqxmd.com/read/28549667/epidemiology-of-cerebrovascular-disease-among-chinese-canadians-with-diabetes
#16
REVIEW
Susy Lam, Joseph Y Chu
BACKGROUND: First-generation Chinese Canadians have usually maintained different lifestyles before immigration to North America, and the question of whether Chinese Canadians with type 2 diabetes have a different stroke profile than that of non-Chinese Canadians remains unanswered. OBJECTIVES: To determine whether 1) Chinese Canadians who have had a stroke within the last 15 years are more likely to have diabetes than non-Chinese Canadians and 2) to explore differences in stroke profiles between the 2 cohorts...
May 23, 2017: Canadian Journal of Diabetes
https://www.readbyqxmd.com/read/28528246/the-canadian-hypoglycemia-assessment-tool-program-insights-into-rates-and-implications-of-hypoglycemia-from-an-observational-study
#17
Ronnie Aronson, Ronald Goldenberg, Damir Boras, Rasmus Skovgaard, Harpreet Bajaj
OBJECTIVE: The true prevalence of hypoglycemia in insulin-treated patients with diabetes and its impact on patients, employers and healthcare providers is poorly appreciated owing to a paucity of real-world data. The global Hypoglycemia Assessment Tool (HAT) study addressed this issue, and here we report data from the Canadian cohort of patients. METHODS: This noninterventional, 6-month retrospective and 4-week prospective study enrolled patients aged ≥18 years receiving insulin treatment for >12 months from community endocrinology practices...
May 17, 2017: Canadian Journal of Diabetes
https://www.readbyqxmd.com/read/28506815/postpartum-diabetes-testing-rates-after-gestational-diabetes-mellitus-in-canadian-women-a-population-based-study
#18
Sonia Butalia, Lois Donovan, Anamaria Savu, Jeffrey Johnson, Alun Edwards, Padma Kaul
OBJECTIVES: We assessed the rate and type of postpartum glycemic testing in women with impaired glucose tolerance of pregnancy (IGTp) and gestational diabetes mellitus (GDM). We examined whether the likelihood of testing was modulated by patients' characteristics and pregnancy outcomes. METHODS: Our population-level cohort study included data from 132,905 pregnancies between October 1, 2008, and December 31, 2011, in Alberta, Canada. Laboratory data within 270 days before and 1 year after delivery were used to identify pregnancies involving IGTp/GDM and postpartum glycemic testing, respectively...
May 12, 2017: Canadian Journal of Diabetes
https://www.readbyqxmd.com/read/28506814/the-relationship-between-type-2-diabetes-and-breast-cancer-incidence-in-differing-ethnic-groups
#19
REVIEW
Gertraud Maskarinec, Angelique Fontaine, Johanna Eyrun Torfadottir, Lorraine L Lipscombe, Iliana C Lega, Jonine Figueroa, Sarah Wild
In addition to rising type 2 diabetes and breast cancer incidence rates worldwide, diabetes may also increase breast cancer risk, and the association may vary by ethnicity. This review summarizes published data evaluating the association between diabetes and breast cancer in women of Asian, Hispanic and African American ancestry while considering a measure of obesity, body mass index (BMI). Published reports were identified through a search of PubMed and previous publications. Of 15 age-adjusted studies, 11 reported on Asian women from various countries, 3 on Hispanics and 1 on African Americans...
May 12, 2017: Canadian Journal of Diabetes
https://www.readbyqxmd.com/read/28506813/the-effects-of-natural-clinoptilolite-and-nano-sized-clinoptilolite-supplementation-on-glucose-levels-and-oxidative-stress-in-rats-with-streptozotocin-induced-diabetes
#20
Behnoosh Hossein Nia, Sirous Khorram, Hassan Rezazadeh, Abdolrasol Safaiyan, Ali Tarighat-Esfanjani
OBJECTIVE: Oxidative stress has a major role in development of diabetic complications. In this study we investigated whether clinoptilolite and nano-sized clinoptilolite could reduce hyperglycemia and oxidative stress in streptozotocin-induced diabetic rats and attempted to determine which intervention was more effective. METHODS: Thirty-six rats were randomly allocated to 2 groups; 1 group was randomly chosen as a diabetic group and injected with streptozotocin (60 mg/kg body weight in 0...
May 12, 2017: Canadian Journal of Diabetes
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