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Canadian Journal of Diabetes

Juana Carretero Gómez, José Carlos Arévalo Lorido, Ricardo Gómez Huelgas, Dolores García de Lucas, Lourdes Mateos Polo, José Manuel Varela Aguilar, Jose Miguel Seguí Ripoll, Javier Ena
OBJECTIVES: Scientific literature about the combination of glucagon-like peptide-1 receptor agonists (GLP-1ra) and sodium-glucose cotransporter 2 (SGLT2) inhibitors in older patients is scarce. We sought to assess the real-world efficacy and safety of SGLT2 inhibitors and GLP-1ra combination therapy in older patients (>65 years of age). METHODS: This was an observational, prospective, multicenter study based on clinical practice. Patients were stratified according to tertiles of baseline glycated hemoglobin (A1C) levels and to treatment schedule...
September 8, 2018: Canadian Journal of Diabetes
Ian Blumer, Anne B Kenshole, Jacob Stilman, Gary F Lewis
No abstract text is available yet for this article.
September 6, 2018: Canadian Journal of Diabetes
Ravi Reddy, Amanda Wittenberg, Jessica R Castle, Joseph El Youssef, Kerri Winters-Stone, Melanie Gillingham, Peter G Jacobs
OBJECTIVES: Physical exercise is recommended for individuals with type 1 diabetes, yet the effects of exercise on glycemic control are not well established. We evaluated the impact of different modes of exercise on glycemic control in people with type 1 diabetes. METHODS: In a 3-week randomized crossover trial, 10 adults with type 1 diabetes (4 men and 6 women, aged 33±6 years; duration of diabetes, 18±10 years; glycated hemoglobin level, 7.4%±1%) were assigned to 3 weeks of intervention: aerobic exercise (treadmill at 60% of maximum volume of oxygen utilization), resistance training (8 to 12 repetitions of 5 upper and lower body exercises at 60% to 80% of 1 repetition maximum) or no exercise (control)...
August 30, 2018: Canadian Journal of Diabetes
Angela McGibbon, Lenley Adams, Karen Ingersoll, Tina Kader, Barna Tugwell
No abstract text is available yet for this article.
October 2018: Canadian Journal of Diabetes
Robyn L Houlden, Lori Berard, Joshua M Lakoff, Vincent Woo, Jean-François Yale
No abstract text is available yet for this article.
October 2018: Canadian Journal of Diabetes
Lorraine Lipscombe, Gillian Booth, Sonia Butalia, Kaberi Dasgupta, Dean T Eurich, Ronald Goldenberg, Nadia Khan, Lori MacCallum, Baiju R Shah, Scot Simpson
No abstract text is available yet for this article.
October 2018: Canadian Journal of Diabetes
G B John Mancini, Robert A Hegele, Lawrence A Leiter
No abstract text is available yet for this article.
October 2018: Canadian Journal of Diabetes
Abin Chandrakumar, Geert Willem 't Jong, Terry P Klassen
No abstract text is available yet for this article.
October 2018: Canadian Journal of Diabetes
Iliana C Lega, Jason D Pole, Peter C Austin, Cindy Lau, Paul C Nathan, Nancy N Baxter
OBJECTIVE: With continued improvements in survival following childhood cancer, the long-term health consequences of cancer treatments are receiving greater focus. Diabetes is emerging as a potential late effect of cancer therapy; however, the magnitude of risk has not been well established. The goal of our study was to evaluate the risk for diabetes in childhood cancer survivors in Ontario using validated population-based databases. METHODS: We used provincial administrative health databases to compare the rate of diabetes in childhood cancer survivors and controls from the general population...
October 2018: Canadian Journal of Diabetes
Pio Conti, Gianpaolo Ronconi, Spyridon K Kritas, Alessandro Caraffa, Theoharis C Theoharides
Mast cells (MCs) promote guest immune responses to parasites and play a critical role in allergic and inflammatory reactions. Once they have been activated, MCs release highly inflammatory compounds that can provoke serious pathologic signs that can lead to death. MCs generate a number of preformed, de novo synthesized compounds and inflammatory cytokine/chemokine synthesis in response to the high-affinity (Kd=10-10 M) immunoglobulin E receptor triggering. Circulating MC progenitors migrate into arterial intima and develop lesions, mediating inflammation...
October 2018: Canadian Journal of Diabetes
Hang Hu, Hongfei Jiang, Liyan Zhu, Xiaodan Wu, Chunmao Han
OBJECTIVES: Advanced glycation endproducts (AGEs) play a key role in the development of foot complications in people with diabetes. Skin autofluorescence (AF) might noninvasively determine tissue accumulation of AGEs. This study evaluated the association between skin AF and AGE contents in the deep tissues of those with diabetes and the further consequences of such contents. METHODS: Between September 2014 and September 2015, we studied 33 patients, with and without diabetes, who had received lower-limb amputations...
October 2018: Canadian Journal of Diabetes
Mehran Anvari, Rodrigo Lemus, Ruth Breau
Obesity has escalated worldwide and in Canada. Many chronic conditions, including type 2 diabetes, are directly correlated with obesity, and although the benefits and effectiveness of bariatric surgery have been proven in terms of sustained weight loss and improving comorbidities, the procedure is underaccessed and underutilized in Canada. We explored the complex landscape of bariatric surgery in Canada, reviewing the current state and focusing on the volume of procedures nationwide and at the provincial level, the type of surgical procedures performed, their outcomes and their associated complications...
October 2018: Canadian Journal of Diabetes
Akinkunmi Paul Okekunle, Xiaoyan Wu, Wei Duan, Rennan Feng, Ying Li, Changhao Sun
OBJECTIVES: To assess the association between branched-chain amino acid (BCAA) intakes and risk for type 2 diabetes. METHODS: Dietary intakes were assessed in 1,804 people with type 2 diabetes and 7,020 controls with information on nutrient intakes, including BCAAs derived from Chinese food composition tables. Principal component analysis was used to identify dietary patterns (DPs) and multivariable-adjusted odds ratios (ORs) of type 2 diabetes, and 95% confidence intervals (CIs) by quartiles of BCAAs were estimated using logistic regression with 2-sided p<0...
October 2018: Canadian Journal of Diabetes
Paola Luca, Bodiel Haugrud, Allison Husband, Jonathan Dawrant, Danièle Pacaud
OBJECTIVE: To evaluate the impact of the Diabetes Coach Program (DCP) on glycated hemoglobin (A1C) levels in youth with type 1 diabetes. The youth were referred to and participated in the DCP between October 2011 and May 2016. METHODS: The Diabetes Coach visited families in their homes every 1 to 2 weeks and updated patients' diabetes teams regularly. A1C levels before the DCP were compared with A1C levels during and after discharge from the DCP. Six participating families completed satisfaction surveys via telephone...
October 2018: Canadian Journal of Diabetes
Narattaphol Charoenphandhu, Panan Suntornsaratoon, Piangkwan Sa-Nguanmoo, Pongpan Tanajak, Jarinthorn Teerapornpuntakit, Ratchaneevan Aeimlapa, Nipon Chattipakorn, Siriporn Chattipakorn
OBJECTIVE: Obese insulin resistance and type 2 diabetes mellitus profoundly impair bone mechanical properties and bone quality. However, because several antidiabetes drugs, especially thiazolidinediones, further aggravate bone loss in individuals with diabetes, diabetic osteopathy should not be treated by using simply any glucose-lowering agents. Recently, incretins have been reported to affect osteoblast function positively. The present study aimed to investigate the effects of vildagliptin, an inhibitor of dipeptidyl peptidase-4, on bone of rats with high-fat-diet-induced prediabetes...
October 2018: Canadian Journal of Diabetes
Mehdi Bahreini, Amir-Hossein Ramezani, Farideh Shishehbor, Anahita Mansoori
Whether consumption of omega-3 affects circulating adiponectin has not been established. The objective of this study was to evaluate the effect of omega-3 (food or supplement) on circulating adiponectin in patients with type 2 diabetes through a systematic review of meta-analyses of randomized controlled trials. PubMed, Scopus and Web of Science were searched for relevant studies through May 2016. Two researchers screened and abstracted the literature independently. Pooled estimates were obtained using the random-effects models...
October 2018: Canadian Journal of Diabetes
Lori J Tuttle, Daniel C Bittel, Adam J Bittel, David R Sinacore
OBJECTIVES: Diabesity (obesity and diabetes mellitus) has been identified as a potential contributor to early-onset frailty. Impairments contributing to early onset of physical frailty in this population are not well understood, and there is little evidence of the impact of peripheral neuropathy on frailty. The purpose of this study was to determine impairments that contribute to early-onset physical frailty in individuals with diabesity and peripheral neuropathy. METHODS: We studied 105 participants, 82 with diabesity and peripheral neuropathy (57 years of age, body mass index [BMI] 31 kg/m2 ); 13 with diabesity only (53 years of age, BMI 34 kg/m2 ) and 10 obese controls (67 years of age, BMI 32 kg/m2 )...
October 2018: Canadian Journal of Diabetes
Jean-Eric Tarride, Allan Smofsky, Priscilla Nykoliation, Stephen Allain, Linda Lewis-Daly, David Satok, Jeremy Schwartz, Joshua Hart Pollack, Jason Robert Guertin, Roger S McIntyre
OBJECTIVES: There is a lack of Canadian data concerning the effectiveness of diabetes interventions in the workplace. The objective of this study was to evaluate the effectiveness of Motivaction, a diabetes screening and education pilot program, in the workplace. METHODS: The Motivaction program involves a voluntary web-based diabetes health-risk assessment, the Canadian Diabetes Risk Questionnaire (CANRISK), combined with an opportunity for those eligible (i.e...
October 2018: Canadian Journal of Diabetes
Karmon E Helmle, Sunita Chacko, Trevor Chan, Alison Drake, Alun L Edwards, Glenda E Moore, Leta C Philp, Naomi Popeski, Rhonda L Roedler, Edwin J R Rogers, Gabrielle L Zimmermann, Julie McKeen
OBJECTIVES: To develop and evaluate a Basal Bolus Insulin Therapy (BBIT) Knowledge Translation toolkit to address barriers to adoption of established best practice with BBIT in the care of adult inpatients. METHODS: This study was conducted in 2 phases and focused on the hospitalist provider group across 4 acute care facilities in Calgary. Phase 1 involved a qualitative evaluation of provider and site specific barriers and facilitators, which were mapped to validated interventions using behaviour change theory...
October 2018: Canadian Journal of Diabetes
Masako Matsugasumi, Yoshitaka Hashimoto, Hiroshi Okada, Muhei Tanaka, Toshihiro Kimura, Noriyuki Kitagawa, Yoshimitsu Tanaka, Yukiko Fukuda, Ryousuke Sakai, Masahiro Yamazaki, Yohei Oda, Naoto Nakamura, Michiaki Fukui
OBJECTIVES: In this study, we aimed to elucidate the association between taste acuity and serum zinc concentration in patients with type 2 diabetes. METHODS: We enrolled 29 patients who were hospitalized and asked them to attend a 2-week diabetes education program. Fasting blood samples were obtained on the morning of the first day and 2 weeks after hospitalization. The acuity of sweet, salty, sour or bitter taste was evaluated by a filter-paper disc method. Correlations among taste acuity, glycemic control and serum zinc concentration were analyzed using the Spearman rank correlation coefficient...
October 2018: Canadian Journal of Diabetes
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