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Molecular Cancer

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https://www.readbyqxmd.com/read/28288645/mesothelin-promotes-epithelial-to-mesenchymal-transition-and-tumorigenicity-of-human-lung-cancer-and-mesothelioma-cells
#1
Xiaoqing He, Liying Wang, Heimo Riedel, Kai Wang, Yong Yang, Cerasela Zoica Dinu, Yon Rojanasakul
BACKGROUND: Lung cancer and pleural mesothelioma are two of the most deadly forms of cancer. The prognosis of lung cancer and mesothelioma is extremely poor due to limited treatment modalities and lack of understanding of the disease mechanisms. We have identified mesothelin as a potentially unique therapeutic target that as a specific advantage appears nonessential in most cell types. Mesothelin (MSLN), a plasma membrane differentiation antigen, is expressed at a high level in many human solid tumors, including 70% of lung cancer and nearly all mesotheliomas...
March 14, 2017: Molecular Cancer
https://www.readbyqxmd.com/read/28288641/sox2-regulates-multiple-malignant-processes-of-breast-cancer-development-through-the-sox2-mir-181a-5p-mir-30e-5p-tusc3-axis
#2
Kuancan Liu, Fuan Xie, Anding Gao, Rui Zhang, Long Zhang, Zhangwu Xiao, Qiong Hu, Weifeng Huang, Qiaojia Huang, Baoshun Lin, Jian Zhu, Haikun Wang, Jianwen Que, Xiaopeng Lan
BACKGROUND: High levels of SOX2 protein are correlated with increased dissemination of breast cancer. However, the underlying molecular mechanisms are not fully understood. METHODS: In this study we investigate the role of SOX2 in breast cancer metastasis using multiple in vitro and in vivo assays including cell culture, shRNA-mediated knockdown, wound healing, colony formation, transwell chamber, xenograft and tail vein injection. Moreover, western blot, immunostaining, microarray and real-time PCR were used to determine the change of protein and miRNA levels...
March 14, 2017: Molecular Cancer
https://www.readbyqxmd.com/read/28288630/overexpression-of-g-protein-coupled-receptor-gpr87-promotes-pancreatic-cancer-aggressiveness-and-activates-nf-%C3%AE%C2%BAb-signaling-pathway
#3
Li Wang, Wei Zhou, Yunfeng Zhong, Yongbao Huo, Ping Fan, Sudong Zhan, Jun Xiao, Xin Jin, Shanmiao Gou, Tao Yin, Heshui Wu, Tao Liu
BACKGROUND: Pancreatic cancer is a highly lethal disease and has the worst prognosis of any major malignancy. G protein-coupled receptor GPR87 is reported to be overexpressed in multiple cancers. The clinical significance and biological role of GPR87 in pancreatic cancer, however, remain to be established. METHODS: GPR87 expression in pancreatic cancer cell lines, paired patient tissues were determined using western blotting and Real-time PCR. Ninety-six human pancreatic cancer tissue samples were analyzed by immunochemistry (IHC) to investigate the association between GPR87 expression and the clinicopathological characteristics of pancreatic cancer...
March 14, 2017: Molecular Cancer
https://www.readbyqxmd.com/read/28288624/cdk5-links-with-dna-damage-response-and-cancer
#4
REVIEW
Wan Liu, Jun Li, Yu-Shu Song, Yue Li, Yu-Hong Jia, Hai-Dong Zhao
As an atypical member of cyclin dependent kinase family, Cyclin dependent kinase 5 (Cdk5) is considered as a neuron-specific kinase in the past decade due to the abundant existence of its activator p35 in post-mitotic neurons. Recent studies show that Cdk5 participates in a series of biological and pathological processes in non-neuronal cells, and is generally dysregulated in various cancer cells. The inhibition or knockdown of Cdk5 has been proven to play an anti-cancer role through various mechanisms, and can synergize the killing effect of chemotherapeutics...
March 14, 2017: Molecular Cancer
https://www.readbyqxmd.com/read/28284220/serum-microrna-profiling-in-patients-with-glioblastoma-a-survival-analysis
#5
LETTER
Hua Zhao, Jie Shen, Tiffany R Hodges, Renduo Song, Gregory N Fuller, Amy B Heimberger
Because circulating microRNAs (miRNAs) have drawn a great deal of attention as promising novel cancer diagnostics and prognostic biomarkers, we sought to identify serum miRNAs significantly associated with outcome in glioblastoma patients. To do this, we performed global miRNA profiling in serum samples from 106 primary glioblastoma patients. The study subjects were randomly divided into two sets: set one (n = 40) and set two (n = 66). Using a Cox regression model, 3 serum miRNAs (miR-106a-5p, miR-182, and miR-145-5p) and 5 serum miRNAs (miR-222-3p, miR-182, miR-20a-5p, miR-106a-5p, and miR-145-5p) were identified significantly associated with 2-year patient overall survival and disease-free survival (P < 0...
March 11, 2017: Molecular Cancer
https://www.readbyqxmd.com/read/28279183/circles-reshaping-the-rna-world-from-waste-to-treasure
#6
REVIEW
Jing Liu, Tian Liu, Xiaman Wang, Aili He
A new type of RNAs was identified from genes traditionally thought to express messenger or linear ncRNA (noncoding RNA) only. They were subsequently named as circRNAs (circular RNAs) due to the covalently closed structure. Accumulating studies were performed to explore the expression profile of circRNAs in different cell types and diseases, the outcomes totally changed our view of ncRNAs, which was thought to be junk by-products in the process of gene transcription, and enriched our poor understanding of its underlying functions...
March 9, 2017: Molecular Cancer
https://www.readbyqxmd.com/read/28270211/syndecan-1-is-a-novel-molecular-marker-for-triple-negative-inflammatory-breast-cancer-and-modulates-the-cancer-stem-cell-phenotype-via-the-il-6-stat3-notch-and-egfr-signaling-pathways
#7
Sherif Abdelaziz Ibrahim, Ramy Gadalla, Eslam A El-Ghonaimy, Omnia Samir, Hossam Taha Mohamed, Hebatallah Hassan, Burkhard Greve, Mohamed El-Shinawi, Mona Mostafa Mohamed, Martin Götte
BACKGROUND: Inflammatory breast cancer (IBC), a particularly aggressive form of breast cancer, is characterized by cancer stem cell (CSC) phenotype. Due to a lack of targeted therapies, the identification of molecular markers of IBC is of major importance. The heparan sulfate proteoglycan Syndecan-1 acts as a coreceptor for growth factors and chemokines, modulating inflammation, tumor progression, and cancer stemness, thus it may emerge as a molecular marker for IBC. METHODS: We characterized expression of Syndecan-1 and the CSC marker CD44, Notch-1 & -3 and EGFR in carcinoma tissues of triple negative IBC (n = 13) and non-IBC (n = 17) patients using qPCR and immunohistochemistry...
March 7, 2017: Molecular Cancer
https://www.readbyqxmd.com/read/28270148/mdm4-actively-restrains-cytoplasmic-mtorc1-by-sensing-nutrient-availability
#8
Francesca Mancini, Emanuela Teveroni, Giusy Di Conza, Valentina Monteleone, Ivan Arisi, Marsha Pellegrino, Marianna Buttarelli, Luisa Pieroni, Mara D'Onofrio, Andrea Urbani, Alfredo Pontecorvi, Massimiliano Mazzone, Fabiola Moretti
BACKGROUND: Many tumor-related factors have shown the ability to affect metabolic pathways by paving the way for cancer-specific metabolic features. Here, we investigate the regulation of mTORC1 by MDM4, a p53-inhibitor with oncogenic or anti-survival activities depending on cell growth conditions. METHOD: MDM4-mTOR relationship was analysed through experiments of overexpression or silencing of endogenous proteins in cell culture and using purified proteins in vitro...
March 7, 2017: Molecular Cancer
https://www.readbyqxmd.com/read/28270146/bmi1-a-new-target-of-ck2%C3%AE
#9
Soumyajit Banerjee Mustafi, Prabir Kumar Chakraborty, Shailendra Kumar Dhar Dwivedi, Kai Ding, Katherine M Moxley, Priyabrata Mukherjee, Resham Bhattacharya
BACKGROUND: The polycomb group protein, BMI1 plays important roles in chromatin modification, stem cell function, DNA damage repair and mitochondrial bioenergetics. Such diverse cellular functions of BMI1 could be, in part, due to post-translational modifications, especially phosphorylation. To date, AKT has been reported as a kinase that by site specific phosphorylation of BMI1 modulates its oncogenic functions. METHODS: Immunoprecipitation in conjunction with kinase assay and mass spectrometry was used to determine association with and site specific phosphorylation of BMI1 by CK2α...
March 7, 2017: Molecular Cancer
https://www.readbyqxmd.com/read/28264681/ion-channels-or-aquaporins-as-novel-molecular-targets-in-gastric-cancer
#10
REVIEW
Jianling Xia, Hongqiang Wang, Shi Li, Qinghui Wu, Li Sun, Hongxiang Huang, Ming Zeng
Gastric cancer (GC) is a common disease with few effective treatment choices and poor prognosis, and has the second-highest mortality rates among all cancers worldwide. Dysregulation and/or malfunction of ion channels or aquaporins (AQPs) are common in various human cancers. Furthermore, ion channels are involved in numerous important aspects of the tumor aggressive phonotype, such as proliferation, cell cycle, apoptosis, motility, migration, and invasion. Indeed, by localizing in the plasma membrane, ion channels or AQPs can sense and respond to extracellular environment changes; thus, they play a crucial role in cell signaling and cancer progression...
March 6, 2017: Molecular Cancer
https://www.readbyqxmd.com/read/28257633/mir-19a-promotes-colorectal-cancer-proliferation-and-migration-by-targeting-tia1
#11
Yanqing Liu, Rui Liu, Fei Yang, Rongjie Cheng, Xiaorui Chen, Shufang Cui, Yuanyuan Gu, Wu Sun, Chaoying You, Zhijian Liu, Feng Sun, Yanbo Wang, Zheng Fu, Chao Ye, Chenyu Zhang, Jing Li, Xi Chen
BACKGROUND: Colorectal cancer (CRC) is a major worldwide health problem due to its high prevalence and mortality rate. T-cell intracellular antigen 1 (TIA1) is an important tumor suppressor involved in many aspects of carcinogenesis and cancer development. How TIA1 expression is regulated during CRC development remains to be carefully elucidated. METHODS: In CRC tissue sample pairs, TIA1 protein and mRNA levels were monitored by Western blot and qRT-PCR, respectively...
March 4, 2017: Molecular Cancer
https://www.readbyqxmd.com/read/28245869/regulation-of-stem-like-cancer-cells-by-glutamine-through-%C3%AE-catenin-pathway-mediated-by-redox-signaling
#12
Jianwei Liao, Pan-Pan Liu, Guoxin Hou, Jiajia Shao, Jing Yang, Kaiyan Liu, Wenhua Lu, Shijun Wen, Yumin Hu, Peng Huang
BACKGROUND: Cancer stem cells (CSCs) are thought to play an important role in tumor recurrence and drug resistance, and present a major challenge in cancer therapy. The tumor microenvironment such as growth factors, nutrients and oxygen affect CSC generation and proliferation by providing the necessary energy sources and growth signals. The side population (SP) analysis has been used to detect the stem-like cancer cell populations based on their high expression of ABCG2 that exports Hoechst-33342 and certain cytotoxic drugs from the cells...
February 28, 2017: Molecular Cancer
https://www.readbyqxmd.com/read/28245823/the-epithelial-to-mesenchymal-transition-emt-and-cancer-stem-cells-implication-for-treatment-resistance-in-pancreatic-cancer
#13
REVIEW
Pingting Zhou, Bo Li, Furao Liu, Meichao Zhang, Qian Wang, Yuanhua Liu, Yuan Yao, Dong Li
The mechanical properties of epithelial to mesenchymal transition (EMT) and a pancreatic cancer subpopulation with stem cell properties have been increasingly recognized as potent modulators of the effective of therapy. In particular, pancreatic cancer stem cells (PCSCs) are functionally important during tumor relapse and therapy resistance. In this review we have surveyed recent advances in the role of EMT and PCSCs in tumor progression, metastasis and treatment resistance, and the mechanisms of integrated with biochemical signals and the underlying pathways involved in treatment resistance of pancreatic cancer...
February 28, 2017: Molecular Cancer
https://www.readbyqxmd.com/read/28241871/a-loss-of-host-derived-mmp-7-promotes-myeloma-growth-and-osteolytic-bone-disease-in-vivo
#14
S T Lwin, J A Fowler, M T Drake, J R Edwards, C C Lynch, C M Edwards
Matrix metalloproteinases (MMPs) play a critical role in cancer pathogenesis, including tumor growth and osteolysis within the bone marrow microenvironment. However, the anti-tumor effects of MMPs are poorly understood, yet have significant implications for the therapeutic potential of targeting MMPs. Host derived MMP-7 has previously been shown to support the growth of bone metastatic breast and prostate cancer. In contrast and underscoring the complexity of MMP biology, here we identified a tumor-suppressive role for host MMP-7 in the progression of multiple myeloma in vivo...
February 28, 2017: Molecular Cancer
https://www.readbyqxmd.com/read/28241836/microrna-29c-functions-as-a-tumor-suppressor-by-targeting-vegfa-in-lung-adenocarcinoma
#15
Lipin Liu, Nan Bi, Lihong Wu, Xiao Ding, Yu Men, Wei Zhou, Lin Li, Weimin Zhang, Susheng Shi, Yongmei Song, Luhua Wang
BACKGROUND: Lung adenocarcinoma (LAD) is considered to be a highly aggressive disease with heterogeneous prognosis and the molecular mechanisms underlying tumor progression remain elusive. Growing evidence demonstrates that the dysregulation of microRNAs (miRNAs) plays an important role in various tumor processes. The aim of this study is to discover prognostic miRNA and investigate its role involved in progression of LAD. METHODS: Prognosis related miRNA was detected by miRNA microarray using formalin-fixed paraffin-embedded (FFPE) specimens from 87 patients with IIIA-N2 LAD...
February 28, 2017: Molecular Cancer
https://www.readbyqxmd.com/read/28241835/mitochondrial-dna-sequencing-demonstrates-clonality-of-peritoneal-implants-of-borderline-ovarian-tumors
#16
LETTER
Giulia Girolimetti, Pierandrea De Iaco, Martina Procaccini, Riccardo Panzacchi, Ivana Kurelac, Laura Benedetta Amato, Giulia Dondi, Giacomo Caprara, Claudio Ceccarelli, Donatella Santini, Anna Maria Porcelli, Anna Myriam Perrone, Giuseppe Gasparre
Borderline ovarian tumors are rare low malignant potential neoplasms characterized by the absence of stromal invasion, whose main prognostic factors are stage and type of peritoneal implants. The latter are defined as invasive when cell proliferation invades the underlying tissue (peritoneal surface, omentum and intestinal wall), or noninvasive. It is still unknown if these implants are metastatic spread from the primary ovarian mass or a neoplastic transformation de novo of the peritoneal surface. Mitochondrial DNA sequencing was performed to assess clonality in eight patients presenting both borderline ovarian tumors and implants...
February 27, 2017: Molecular Cancer
https://www.readbyqxmd.com/read/28241827/microrna-30d-promotes-angiogenesis-and-tumor-growth-via-mypt1-c-jun-vegfa-pathway-and-predicts-aggressive-outcome-in-prostate-cancer
#17
Zhuo-Yuan Lin, Guo Chen, Yan-Qiong Zhang, Hui-Chan He, Yu-Xiang Liang, Jian-Heng Ye, Ying-Ke Liang, Ru-Jun Mo, Jian-Ming Lu, Yang-Jia Zhuo, Yu Zheng, Fu-Neng Jiang, Zhao-Dong Han, Shu-Lin Wu, Wei-de Zhong, Chin-Lee Wu
BACKGROUND: Even though aberrant expression of microRNA (miR)-30d has been reported in prostate cancer (PCa), its associations with cancer progression remain contradictory. The aim of this study was to investigate clinical significance, biological functions and underlying mechanisms of miR-30d deregulation in PCa. METHODS: Involvement of miR-30d deregulation in malignant phenotypes of PCa was demonstrated by clinical sample evaluation, and in vitro and in vivo experiments...
February 27, 2017: Molecular Cancer
https://www.readbyqxmd.com/read/28231808/itih5-mediates-epigenetic-reprogramming-of-breast-cancer-cells
#18
Michael Rose, Vera Kloten, Erik Noetzel, Lukas Gola, Josef Ehling, Timon Heide, Steffen K Meurer, Aljona Gaiko-Shcherbak, Antonio S Sechi, Sebastian Huth, Ralf Weiskirchen, Oliver Klaas, Wiebke Antonopoulos, Qiong Lin, Wolfgang Wagner, Jürgen Veeck, Felix Gremse, Julia Steitz, Ruth Knüchel, Edgar Dahl
BACKGROUND: Extracellular matrix (ECM) is known to maintain epithelial integrity. In carcinogenesis ECM degradation triggers metastasis by controlling migration and differentiation including cancer stem cell (CSC) characteristics. The ECM-modulator inter- α-trypsin inhibitor heavy chain family member five (ITIH5) was recently identified as tumor suppressor potentially involved in impairing breast cancer progression but molecular mechanisms underlying its function are still elusive. METHODS: ITIH5 expression was analyzed using the public TCGA portal...
February 23, 2017: Molecular Cancer
https://www.readbyqxmd.com/read/28231799/mechanistic-added-value-of-a-trans-sulfonamide-platinum-complex-in-human-melanoma-cell-lines-and-synergism-with-cis-platin
#19
Alba Agudo-López, Elena Prieto-García, José Alemán, Carlos Pérez, C Vanesa Díaz-García, Lucía Parrilla-Rubio, Silvia Cabrera, Carmen Navarro-Ranninger, Hernán Cortés-Funes, José A López-Martín, M Teresa Agulló-Ortuño
BACKGROUND: Cisplatin is a potent antitumor agent. However, toxicity and primary and secondary resistance are major limitations of cisplatin-based chemotherapy, leading to therapeutic failure. We have previously reported that mono-sulfonamide platinum complexes have good antitumor activity against different tumoral cell lines and with a different and better cytotoxic profile than cisplatin. Besides, N-sulfonamides have been used extensively in medicinal chemistry as bactericides, anticonvulsant, inhibitors of the carbonic anhydrase, inhibitors of histone deacetylases, and inhibitors of microtubule polymerization, among others...
February 23, 2017: Molecular Cancer
https://www.readbyqxmd.com/read/28231797/kcnma1-cooperating-with-ptk2-is-a-novel-tumor-suppressor-in-gastric-cancer-and-is-associated-with-disease-outcome
#20
Gaoxiang Ma, Hanting Liu, Qiuhan Hua, Meilin Wang, Mulong Du, Yadi Lin, Yuqiu Ge, Weida Gong, Qinghong Zhao, Fulin Qiang, Guoquan Tao, Zhengdong Zhang, Haiyan Chu
BACKGROUND: Inactivation of tumor suppressor genes by promoter hypermethylation plays a key role in the tumorgenesis. It is necessary to uncover the detailed pattern of whole genome-wide abnormal DNA methylation during the development of gastric cancer (GC). METHOD: We performed a genome-wide methylation detection using 12 paired of GC tissues and their corresponding normal tissues. Methylation-specific PCR (MSP) and bisulphite sequencing (BSP) were used to measure methylation status of specific CpG site...
February 23, 2017: Molecular Cancer
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