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Lipids in Health and Disease

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https://www.readbyqxmd.com/read/29151018/study-of-the-nlrp3-inflammasome-component-genes-and-downstream-cytokines-in-patients-with-type-2-diabetes-mellitus-with-carotid-atherosclerosis
#1
Junli Lee, Jing Wan, Linyun Lee, Changhua Peng, Hailong Xie, Chengbin Lee
BACKGROUND: A role for the NLRP3 inflammasome has been reported in various diseases, such as diabetes mellitus, atherosclerosis (AS), nephropathy, rheumatism, and others, although limited information is available concerning the role of the NLRP3 inflammasome, interleukin-1β (IL-1β) and interleukin-18 (IL-18) in patients with type 2 diabetes mellitus (T2DM) and carotid atherosclerosis (CAS). Therefore, this cross-sectional study investigated these inflammatory components in patients with T2DM complicated with carotid atherosclerosis (T2DM + CAS)...
November 18, 2017: Lipids in Health and Disease
https://www.readbyqxmd.com/read/29145851/ala-la-ameliorates-glucose-toxicity-on-hk-2-cells-by-attenuating-oxidative-stress-and-apoptosis-through-the-ros-p38-tgf-%C3%AE-1-pathway
#2
Mingxia Jiang, Haifen Zhang, Lijie Zhai, Bianliang Ye, Yin Cheng, Chengkai Zhai
BACKGROUND: Growing evidence indicates that oxidative stress (OS) plays a pivotal role in Diabetic nephropathy (DN). In a previous study we demonstrated that ALA/LA protected HK-2 cells against high glucose-induced cytotoxicity. So we aimed to establish the glucose injury model of HK-2 cells and investigate the beneficial effects of ALA/LA on high glucose-induced excessive production of TGF-β1 and the possible mechanisms mediating the effects. METHODS: The expression of OS markers in high glucose-induced HK-2 cells treated with ALA/LA...
November 16, 2017: Lipids in Health and Disease
https://www.readbyqxmd.com/read/29137635/the-association-between-serum-25-hydroxyvitamin-d3-concentration-and-serum-lipids-in-the-rural-population-of-china
#3
Huina Ge, Hualei Sun, Teng Wang, Xinxin Liu, Xing Li, Fei Yu, Han Han, Jun Wang, Wenjie Li
BACKGROUND: Vitamin D deficiency is implicated in some diseases, including cardiovascular. Few studies have assessed the correlation between 25-hydroxyvitamin D3 [25(OH) D3] and serum lipids. In this study, we explored the correlation between serum 25(OH) D3 concentrations and serum lipids with a typical sample of the rural population in China. METHODS: Face-to-face research was used to gather some basic information. Fasting serum concentrations of 25-(OH) D3, total cholesterol (TC), triglyceride (TG), HDL cholesterol (HDL-C) and, LDL cholesterol (LDL-C) tested in the laboratory...
November 14, 2017: Lipids in Health and Disease
https://www.readbyqxmd.com/read/29132429/characterization-of-skin-function-associated-with-obesity-and-specific-correlation-to-local-systemic-parameters-in-american-women
#4
Shinobu Mori, Akiko Shiraishi, Karen Epplen, Desiree Butcher, Daiki Murase, Yuka Yasuda, Takatoshi Murase
BACKGROUND: Obesity is considered problematic not only as a major cause of diabetes, hypertension, and dyslipidemia, but also as a risk of intractable dermatosis; however influence of obesity on skin function has not been clarified. To clarify the mechanism of obesity-associated skin disorders, we aimed to characterize the skin function of subjects with obesity, and identify possible influencing factors. METHODS: Complex analyses including instrumental measurement, biochemical and lipidomics were performed for facial skin and physical evaluation in 93 Caucasian women with obesity (OB) and non-obesity (NOB)...
November 13, 2017: Lipids in Health and Disease
https://www.readbyqxmd.com/read/29132372/hepatitis-b-virus-inhibits-the-in-vivo-and-in-vitro-synthesis-and-secretion-of-apolipoprotein-c3
#5
Chengliang Zhu, Hengcheng Zhu, Hui Song, Limin Xu, Longxuan Li, Fang Liu, Xinghui Liu
BACKGROUND: Hepatitis B virus (HBV) infection in the body can damage liver cells and cause disorders in blood lipid metabolism. Apolipoprotein C3 (ApoC3) plays an important role in the regulation of lipid metabolism, but no study on the HBV regulation of ApoC3 has been reported. This purpose of this study was to investigate the effect of HBV on ApoC3 expression and its regulatory mechanism. METHODS: The expression levels of ApoC3 mRNA and protein in the human hepatoma cell lines HepG2 and HepG2...
November 13, 2017: Lipids in Health and Disease
https://www.readbyqxmd.com/read/29126447/hypoglycemic-and-hypolipidemic-effects-of-different-parts-and-formulations-of-bitter-gourd-momordica-charantia
#6
Mahwish, Farhan Saeed, Muhammad Sajid Arshad, Mahr Un Nisa, Muhammad Tahir Nadeem, Muhammad Umair Arshad
BACKGROUND: Cardiovascular diseases and diabetes are responsible for large number of deaths throughout the globe. Bitter gourd has the potential to become a component of the diet or a dietary supplement for diabetic and pre-diabetic patients owing to the presence of insulin like molecules. Recent investigations have suggested that bitter gourd extracts may ameliorate high fat diet induced obesity and hyperlipidemia in animal models. Moreover, its supplements in food result in lowering weight gain and visceral fat mass...
November 10, 2017: Lipids in Health and Disease
https://www.readbyqxmd.com/read/29126414/high-density-lipoprotein-cholesterol-efflux-capacity-is-inversely-associated-with-cardiovascular-risk-a-systematic-review-and-meta-analysis
#7
Chengfeng Qiu, Xiang Zhao, Quan Zhou, Zhen Zhang
BACKGROUND: A low plasma level of high-density lipoprotein (HDL) cholesterol (HDL-C) is associated with cardiovascular risk. A key cardioprotective property of HDL is cholesterol efflux capacity (CEC), the ability of HDL to accept cholesterol from macrophages. In this study, we aimed to identify the predictive value of CEC for cardiovascular risk. METHODS: The relative risks (RRs) and 95% confidence intervals (CIs) were pooled to analyze the association between CEC and the incidence of cardiovascular events and all-cause mortality...
November 10, 2017: Lipids in Health and Disease
https://www.readbyqxmd.com/read/29121952/association-between-oxidative-stress-and-cord-serum-lipids-in-relation-to-delayed-cord-clamping-in-term-neonates
#8
Asmaa N Moustafa, Mahmoud H Ibrahim, Suzan Omar Mousa, Ebtesam E Hassan, Hashem F Mohamed, Hend M Moness
BACKGROUND: Although delayed cord clamping (DCC) is a recent WHO recommendation, early cord clamping (ECC) is still a routine practice in many countries. Limited researches studied the effect of delayed cord clamping on oxidative stress in term neonates; In this study we aim to assess the influence of cord clamping either early or late on oxidative stress in term neonates and to evaluate the association of oxidative stress and cord blood lipids. METHODS: One-hundred mothers and their term neonates were included in the present study...
November 9, 2017: Lipids in Health and Disease
https://www.readbyqxmd.com/read/29115953/laparoscopic-sleeve-gastrectomy-improves-body-composition-and-alleviates-insulin-resistance-in-obesity-related-acanthosis-nigricans
#9
Yi Zhang, Cuiling Zhu, Xin Wen, Xingchun Wang, Liang Li, Sharvan Rampersad, Liesheng Lu, Donglei Zhou, Chunhua Qian, Ran Cui, Manna Zhang, Peng Yang, Shen Qu, Le Bu
BACKGROUND: Acanthosis nigricans (AN) has a close relationship with obesity. It is believed that obesity and AN have the common pathophysiological basis such as hyperinsulinism. This study is aimed to observe the effect of laparoscopic sleeve gastrectomy (LSG) on body composition and insulin resistance in Chinese obese patients with acanthosis nigricans. METHODS: A total of 37 obese patients who underwent LSG in our hospital were selected for analysis. They were divided into simple obesity (OB n = 14) and obesity with acanthosis nigricans (AN n = 23) group respectively...
November 7, 2017: Lipids in Health and Disease
https://www.readbyqxmd.com/read/29096636/sodium-butyrate-promotes-apoptosis-in-breast-cancer-cells-through-reactive-oxygen-species-ros-formation-and-mitochondrial-impairment
#10
Vahid Salimi, Zahra Shahsavari, Banafsheh Safizadeh, Ameinh Hosseini, Narges Khademian, Masoumeh Tavakoli-Yaraki
BACKGROUND: Sodium butyrate (NaBu) is a short-chain fatty acid which serves as a histon deacetylase inhibitor and has received considerable interest as a possible regulator of cancer cell death. The regulatory effect of NaBu on cancer cell growth or death has yet to be illustrated in many cancers including breast cancer. This study is aimed to elucidate the possible effect of NaBu on regulation of breast cancer growth and apoptosis. METHODS: The cytotoxic effect of NaBu on the growth of breast cancer cells (MCF-7 and MDA-MB-468) and normal breast cells (MCF-10A) was determined using MTT assay...
November 2, 2017: Lipids in Health and Disease
https://www.readbyqxmd.com/read/29084567/the-role-and-function-of-hdl-in-patients-with-diabetes-mellitus-and-the-related-cardiovascular-risk
#11
REVIEW
Marek Femlak, Anna Gluba-Brzózka, Aleksandra Ciałkowska-Rysz, Jacek Rysz
BACKGROUND: Diabetes mellitus (DM) is a major public health problem which prevalence is constantly raising, particularly in low- and middle-income countries. Both diabetes mellitus types (DMT1 and DMT2) are associated with high risk of developing chronic complications, such as retinopathy, nephropathy, neuropathy, endothelial dysfunction, and atherosclerosis. METHODS: This is a review of available articles concerning HDL subfractions profile in diabetes mellitus and the related cardiovascular risk...
October 30, 2017: Lipids in Health and Disease
https://www.readbyqxmd.com/read/29084557/evaluation-of-nutritional-values-phenolic-profile-aroma-compounds-and-biological-properties-of-pittosporum-tobira-seeds
#12
Ilhem Rjeibi, Sana Ncib, Anouar Ben Saad, Sami Souid
BACKGROUND: Plant essential oils and phenolic compounds are widely used for their medicinal properties. Thus, the aim of this study is to evaluate the nutritional values, the chemical composition, antioxidant activity and anti-hemolytic effects of Pittosporum tobira seeds. METHODS: The aroma compounds were isolated using two methods (Headspace-solid phase microextraction (HS-SPME) and hydrodistillation (HD)) and analyzed by gas chromatography coupled with mass spectrometry (GC-MS)...
October 30, 2017: Lipids in Health and Disease
https://www.readbyqxmd.com/read/29078775/visceral-adiposity-and-renal-function-an-observational-study-from-spect-china
#13
Kun Zhang, Qin Li, Yi Chen, Ningjian Wang, Yingli Lu
BACKGROUND: Lipid accumulation product (LAP) is a novel and effective index of visceral adiposity distribution based on waist circumference and triglycerides concentration. Few studies investigated the relationship between LAP and eGFR. We aimed to explore whether LAP was associated with declined renal function (eGFR < 60 mL/min/1.73m(2)), and also whether it exhibited obvious superiority in predicting kidney impairment compared with other obesity indices. METHODS: In this cross-sectional study, 10,012 subjects were recruited from 22 sites in East China...
October 27, 2017: Lipids in Health and Disease
https://www.readbyqxmd.com/read/29037249/a-novel-self-micro-emulsifying-delivery-system-smeds-formulation-significantly-improves-the-fasting-absorption-of-epa-and-dha-from-a-single-dose-of-an-omega-3-ethyl-ester-concentrate
#14
Yan Qin, Hilde Nyheim, Else Marie Haram, Joseph M Moritz, Svein Olaf Hustvedt
BACKGROUND: Absorption of EPA and DHA from Omega-3-acid ethyl ester (EE) concentrate supplements occurs most efficiently when taken in context of a fatty meal; adequate fat intake is required to release bile salts that emulsify and pancreatic enzymes that digest omega-3-containing lipids in the intestine. Current guidelines recommend reduction in fat intake and therefore there is a need to optimize the absorption of Omega-3 in those consuming low-fat or no-fat meals. To this end, BASF has developed an Absorption Acceleration Technology, a novel self-micro-emulsifying delivery system (SMEDS) formulation of highly concentrated Omega-3-acid EE which enables rapid emulsification and microdroplet formation upon entering the aqueous environment of the gut therefore enhances the absorption...
October 16, 2017: Lipids in Health and Disease
https://www.readbyqxmd.com/read/29037239/serum-uric-acid-and-non-alcoholic-fatty-liver-disease-in-non-obesity-chinese-adults
#15
Xiaoya Zheng, Lilin Gong, Rong Luo, Hua Chen, Bin Peng, Wei Ren, Yonghong Wang
BACKGROUND: Previous studies found elevated serum uric acid (SUA) was associated with the development or progression of non-alcoholic fatty liver disease (NAFLD) in general population; in this study we aim to investigate the association of SUA and the severity of NAFLD based on grade of fatty liver on ultrasonography in non-obese subjects. METHODS: Data were obtained from subjects via routine physical examinations in the Public Health Center of our hospital between 2011 and 2014...
October 16, 2017: Lipids in Health and Disease
https://www.readbyqxmd.com/read/29037210/a-vicious-circle-between-insulin-resistance-and-inflammation-in-nonalcoholic-fatty-liver-disease
#16
REVIEW
Zhonge Chen, Rong Yu, Ying Xiong, Fangteng Du, Shuishan Zhu
Nonalcoholic fatty liver disease (NAFLD) comprises a spectrum of diseases, including simple steatosis, nonalcoholic steatohepatitis (NASH), liver cirrhosis and hepatocellular carcinoma. Lipotoxicity, insulin resistance (IR) and inflammation are involved in the disease process. Lipotoxicity promotes inflammation and IR, which in turn, increase adipocyte lipolysis and exacerbates lipotoxicity. Furthermore, IR and inflammation form a vicious circle, with each condition promoting the other and accelerating the development of NAFLD in the presence of lipotoxicity...
October 16, 2017: Lipids in Health and Disease
https://www.readbyqxmd.com/read/29029615/fenofibrate-decreases-the-bone-quality-by-down-regulating-runx2-in-high-fat-diet-induced-type-2-diabetes-mellitus-mouse-model
#17
Tianshu Shi, Ke Lu, Siyu Shen, Qiaoli Tang, Kaijia Zhang, Xiaobo Zhu, Yong Shi, Xianglin Liu, Huajian Teng, Chaojun Li, Bin Xue, Qing Jiang
BACKGROUND: This study is to investigate the effect of fenofibrate on the bone quality of Type 2 diabetes mellitus (T2DM) mouse model. METHODS: T2DM mouse model was induced by high-fat-diet, and the mice were treated with fenofibrate (100 mg/kg) (DIO-FENO) or PBS (DIO-PBS) for 4 weeks. The bone microstructure and biomechanical properties of femora were analyzed by micro-CT and 3-Point bending test. The protein expression was detected by immunohistochemical staining and Western blot...
October 13, 2017: Lipids in Health and Disease
https://www.readbyqxmd.com/read/29025430/genetic-architecture-of-lipid-traits-in-the-hispanic-community-health-study-study-of-latinos
#18
Mariaelisa Graff, Leslie S Emery, Anne E Justice, Esteban Parra, Jennifer E Below, Nicholette D Palmer, Chuan Gao, Qing Duan, Adan Valladares-Salgado, Miguel Cruz, Alanna C Morrison, Eric Boerwinkle, Eric A Whitsel, Charles Kooperberg, Alex Reiner, Yun Li, Carlos Jose Rodriguez, Gregory A Talavera, Carl D Langefeld, Lynne E Wagenknecht, Jill M Norris, Kent D Taylor, George Papanicolaou, Eimear Kenny, Ruth J F Loos, Yii-Der Ida Chen, Cathy Laurie, Tamar Sofer, Kari E North
BACKGROUND: Despite ethnic disparities in lipid profiles, there are few genome-wide association studies investigating genetic variation of lipids in non-European ancestry populations. In this study, we present findings from genetic association analyses for total cholesterol, low density lipoprotein cholesterol (LDL), high density lipoprotein cholesterol (HDL), and triglycerides in a large Hispanic/Latino cohort in the U.S., the Hispanic Community Health Study / Study of Latinos (HCHS/SOL)...
October 12, 2017: Lipids in Health and Disease
https://www.readbyqxmd.com/read/29020963/relation-of-four-nontraditional-lipid-profiles-to-diabetes-in-rural-chinese-h-type-hypertension-population
#19
Haoyu Wang, Xiaofan Guo, Yintao Chen, Zhao Li, Jiaqi Xu, Yingxian Sun
BACKGROUND: Mounting evidence suggested that nontraditional lipid profiles have been recognized as a reliable indicator for unfavorable cardiovascular events. The purpose of this study was to explore the role of nontraditional lipid profiles as potential clinical indices for the assessment of prevalent diabetes in rural Chinese H-type hypertension population. METHODS: During 2012 to 2013, we conducted a large cross-sectional study of 2944 H-type hypertension participants (≥35 years of age) from rural areas in northeast China...
October 11, 2017: Lipids in Health and Disease
https://www.readbyqxmd.com/read/29017604/il-17-differentiated-macrophages-secrete-pro-inflammatory-cytokines-in-response-to-oxidized-low-density-lipoprotein
#20
María de la Paz Sánchez-Martínez, Francisco Blanco-Favela, Mónica Daniela Mora-Ruiz, Adriana Karina Chávez-Rueda, Mariela Bernabe-García, Luis Chávez-Sánchez
BACKGROUND: Cytokines and macrophages play a central role in the development of atherosclerosis. Interleukin (IL)-17 is a pro-inflammatory cytokine with differential effects on innate immune cells. We investigated the effects of IL-17 on macrophage differentiation and foam cell formation and activation in response to oxidized low-density lipoprotein (oxLDL). METHODS: Human monocytes were treated with IL-17 to induce macrophage differentiation. As controls, human monocytes were differentiated into M1 macrophages (M1) or M2 macrophages (M2)...
October 10, 2017: Lipids in Health and Disease
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