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Lipids in Health and Disease

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https://www.readbyqxmd.com/read/29789011/novel-phenoxazinones-as-potent-agonist-of-ppar-%C3%AE-design-synthesis-molecular-docking-and-in-vivo-studies
#1
David I Ugwu, Uchechukwu C Okoro, Narendra K Mishra, Sunday N Okafor
BACKGROUND: The use of statin, a 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitor for the treatment of dyslipidemia has been associated with dose limiting hepatoxicity, mytotoxicity and tolerability due to myalgias thereby necessitating the synthesis of new drug candidates for the treatment of lipid disorder. METHODS: The reaction of appropriate benzenesulphonamide with substituted phenoxazinone in the presence of phenylboronic acid gave the targeted compounds...
May 22, 2018: Lipids in Health and Disease
https://www.readbyqxmd.com/read/29788974/eicosapentaenoic-acid-ethyl-ester-improves-endothelial-dysfunction-in-type-2-diabetic-mice
#2
Yasuhiro Takenouchi, Kazuo Ohtake, Koji Nobe, Keizo Kasono
BACKGROUND: Eicosapentaenoic acid (EPA) is thought to have many beneficial effects, such as anti-atherosclerogenic and anti-inflammatory properties. However, few studies have reported its effects of endothelial dysfunction in diabetes and its direct effects on the aorta. Here, we investigated the effects of EPA treatment on impaired endothelium-dependent relaxation of the aorta in KKAy mice, a model of type 2 diabetes. METHODS: Male KKAy mice were fed a high-fat (HF) diet for 8 weeks to induce diabetes, after which they were divided into two groups...
May 22, 2018: Lipids in Health and Disease
https://www.readbyqxmd.com/read/29788966/dyslipidemia-prevalence-awareness-treatment-control-and-risk-factors-in-chinese-rural-population-the-henan-rural-cohort-study
#3
Xiaotian Liu, Songcheng Yu, Zhenxing Mao, Yuqian Li, Haiqing Zhang, Kaili Yang, Honglei Zhang, Ruihua Liu, Xinling Qian, Linlin Li, Ronghai Bie, Chongjian Wang
BACKGROUND: The prevalence of dyslipidemia continue to increase in recent decades in China, however, little is known about the recent prevalence, awareness, treatment, control, and potential risk factors of dyslipidemia in the rural areas of China. METHODS: A total of 39,207 participants aged 18-79 years were recruited for the epidemiological research from the Henan Rural Cohort study. The age- and sex-adjusted means (95% confidence intervals, CI) of serum lipid levels or percentages of prevalence, awareness, treatment, and control overall and in various population subgroups were estimated and compared by multiple linear regression or logistic regression...
May 22, 2018: Lipids in Health and Disease
https://www.readbyqxmd.com/read/29776362/apolipoprotein-b-apolipoprotein-a1-ratio-and-mortality-among-incident-peritoneal-dialysis-patients
#4
Xiaojiang Zhan, Yanbing Chen, Caixia Yan, Siyi Liu, Lijuan Deng, Yuting Yang, Panlin Qiu, Dan Pan, Bingxiang Zeng, Qinkai Chen
BACKGROUND: To investigate the association between the ratio of apolipoprotein B (apo B) / apolipoprotein A1 (apo A1) with all-cause mortality and cardiovascular events in peritoneal dialysis (PD) patients. METHODS: Eight hundred and sixty incident PD patients were enrolled from November 1, 2005, to February 28, 2017, and followed until May 31, 2017. Outcomes were all-cause mortality and cardiovascular events. Associations between the apo B/apo A1 ratio with all-cause mortality and cardiovascular events were evaluated using multivariable-adjusted Cox models...
May 17, 2018: Lipids in Health and Disease
https://www.readbyqxmd.com/read/29769126/polymorphism-and-plasma-levels-of-apolipoprotein-e-and-the-risk-of-aneurysmal-subarachnoid-hemorrhage-in-a-chinese-population-a-case-control-study
#5
Xiaofeng Liu, Weiwu Zhan, Qiumei Wu, Fengqing Wang, Bin Yang, Qishui Ou
BACKGROUND: Aneurysmal subarachnoid hemorrhage (aSAH) is the most common types of subarachnoid hemorrhage, which is a critical clinical problem with high morbidity, mortality, and economic impact. Recent studies have shown that APOE was a genetic risk factor of aSAH, however, the studies lack consistent conclusions and the evidence from Chinese Han population is rare. OBJECTIVE: To determine the relationship between APOE polymorphism and the incidence of aSAH in Chinese Fujian Han population and explore the possible mechanism of ApoE in the pathogenesis of aSAH...
May 16, 2018: Lipids in Health and Disease
https://www.readbyqxmd.com/read/29769067/antioxidant-capacity-of-cinnamon-extract-for-palm-oil-stability
#6
Muhammad Zia Shahid, Hafiza Saima, Adeela Yasmin, Muhammad Tahir Nadeem, Muhammad Imran, Muhammad Afzaal
BACKGROUND: Spices and their bioactive components are more promising attractions for their inclusion in diet-based regimes to improve human health. These are sources of natural antioxidants and play an important role in the chemoprevention of diseases and aging. The aim of the current study was to explore the antioxidant potential of cinnamon; a widely used spice throughout the world. METHODS: The current research was aimed to investigate the antioxidant potential of cinnamon extract...
May 16, 2018: Lipids in Health and Disease
https://www.readbyqxmd.com/read/29759071/metformin-attenuates-triglyceride-accumulation-in-hepg2-cells-through-decreasing-stearyl-coenzyme-a-desaturase-1-expression
#7
Xiaopeng Zhu, Hongmei Yan, Mingfeng Xia, Xinxia Chang, Xi Xu, Liu Wang, Xiaoyang Sun, Yan Lu, Hua Bian, Xiaoying Li, Xin Gao
BACKGROUND: The prevalence of nonalcoholic fatty liver disease (NAFLD) has increased worldwide. Metformin decreases triglyceride (TG) accumulation in hepatocytes in vivo and in vitro. Stearyl-coenzyme A desaturase 1 (SCD1) knockout mice also show decreased liver TG accumulation; however, whether SCD1 plays a role in the effect of metformin on TG accumulation is unknown. Therefore, the aim of this study was to investigate whether SCD1 mediated the effect of metformin on TG accumulation...
May 14, 2018: Lipids in Health and Disease
https://www.readbyqxmd.com/read/29751766/changes-in-lipid-indices-and-body-composition-one-year-after-laparoscopic-gastrectomy-a-prospective-study
#8
Soo Jin Lee, Ji Young Kim, Tae Kyung Ha, Yun Young Choi
BACKGROUND: The purpose of this prospective study was to investigate changes in lipid indices associated with whole body composition during 1 year of follow-up after laparoscopic gastrectomy. METHODS: Thirty-seven patients with benign and malignant gastric neoplasm who underwent laparoscopic gastrectomy were prospectively enrolled. None of the patients were treated with adjuvant chemotherapy. Lipid indices and body composition were measured preoperatively and at six and 12 months after laparoscopic gastrectomy...
May 11, 2018: Lipids in Health and Disease
https://www.readbyqxmd.com/read/29747697/low-lpa-gene-kringle-iv-2-repeat-copy-number-association-with-elevated-lipoprotein-a-concentration-as-an-independent-risk-factor-of-coronary-atherosclerotic-heart-disease-in-the-chinese-han-population
#9
Lishan Sun, Ming Zong, Cuncun Chen, Lihong Xie, Fei Wu, Ming Yu, Lieying Fan
BACKGROUND: Lipoprotein (a) [Lp(a)], which is genetically determined by the LPA gene kringle IV type 2 (KIV-2) repeat copy number, has previously been reported in different populations. However, it is uncertain if the same occurs in the Chinese Han population. This study explored the correlation of Lp(a) mass or particle concentration with KIV-2 repeat copy number and application for coronary atherosclerotic heart disease (CAHD) risk assessment. METHODS: A cross-sectional study including 884 subjects was conducted...
May 10, 2018: Lipids in Health and Disease
https://www.readbyqxmd.com/read/29747696/oxidative-modifications-of-foetal-ldl-c-and-hdl-c-lipoproteins-in-preeclampsia
#10
G León-Reyes, S Espino Y Sosa, R Medina-Navarro, A M Guzmán-Grenfell, A X Medina-Urrutia, S Fuentes-García, G J J Hicks, Y D Torres-Ramos
BACKGROUND: Oxidative modifications have been observed in lipids and proteins in lipoproteins isolated from women with preeclampsia. Thus, newborns could also be susceptible to this damage directly through their mothers. In this study, we evaluated the oxidative profile of LDL-c and HDL-c lipoproteins isolated from the umbilical cord from newborns born to women with preeclampsia. METHODS: Thirty newborns born to women with preeclampsia and thirty newborns born to women with healthy pregnancies were included...
May 10, 2018: Lipids in Health and Disease
https://www.readbyqxmd.com/read/29747667/protective-effect-of-grape-seed-and-skin-extract-against-high-fat-diet-induced-dyshomeostasis-of-energetic-metabolism-in-rat-lung
#11
Mohamed El Ayed, Safwen Kadri, Maha Mabrouk, Ezzedine Aouani, Salem Elkahoui
BACKGROUND: Obesity is currently one of the major epidemics of this millennium and affects poeples throughout the world. It causes multiple systemic complications as it significantly interferes with respiratory function. OBJECTIVE: We aimed in the present work to study the effect of high fat diet (HFD) on lung oxidative stress and energy metabolism alterations, as well as the putative protection afforded by grape seed and skin extract (GSSE). METHODS: We started by characterizing the GSSE and its composition using gas chromatography coupled to mass spectrometry (GC-MS)...
May 10, 2018: Lipids in Health and Disease
https://www.readbyqxmd.com/read/29747663/the-lipid-lowering-effects-of-danhong-and-huangqi-injections-a-meta-analysis-of-clinical-controlled-trials
#12
Liuqin Yu, Chunyang Zhou, Zhi Luo, Wei Zeng, Feiya Lai, Gangjie Han, Yongyan Song
BACKGROUND: Dyslipidaemia is a major risk factor for coronary heart disease (CHD). Danhong and Huangqi injections, two traditional Chinese medicine prescriptions, have been widely studied regarding their lipid-lowering properties. However, the results were inconsistent and inconclusive. Thus, we conducted this meta-analysis of clinical controlled trials to clarify the lipid-lowering effects of Danhong and Huangqi injections. METHODS: The databases including PubMed, Google Scholar, Web of Science, Cochrane Library, Wanfang Database, CNKI and VIP were searched...
May 10, 2018: Lipids in Health and Disease
https://www.readbyqxmd.com/read/29747660/association-of-the-apoa1-rs964184-snp-and-serum-lipid-traits-in-the-chinese-maonan-and-han-populations
#13
Ling Qiu, Rui-Xing Yin, Eksavang Khounphinith, Fen-Han Zhang, De-Zhai Yang, Shang-Ling Pan
BACKGROUND: Maonan nationality belongs to a mountain ethnic minority in China. Little is known about the association of apolipoprotein A1 gene (APOA1) rs964184 single nucleotide polymorphism (SNP) and serum lipid levels in this population. The aim of this study was to detect the association of the APOA1 rs964184 SNP and several environmental factors with serum lipid profiles in the Chinese Maonan and Han populations. METHODS: Genotypes of the APOA1 rs964184 SNP in 867 individuals of Maonan nationality and 820 participants of Han nationality were determined by polymerase chain reaction and restriction fragment length polymorphism, combined with gel electrophoresis, and confirmed by direct sequencing...
May 10, 2018: Lipids in Health and Disease
https://www.readbyqxmd.com/read/29747646/effect-of-dietary-intervention-treatment-on-children-with-iron-deficiency-anemia-in-china-a-meta-analysis
#14
Jian Sun, Lei Zhang, Jing Cui, Shanshan Li, Hongting Lu, Yong Zhang, Haiming Li, Jianping Sun, Zulqarnain Baloch
BACKGROUND: Previous studies have shown beneficial effects of dietary approaches for iron deficiency anemia (IDA) control. This study was design to investigate the effect of dietary intervention treatment on children with iron deficiency anemia. METHODS: We performed a systematic review of published dietary interventions effect on IDA treatment through meta-analysis. CBM, CNKI, Wanfang database, EMBASE, VIP, PubMed and Web of science database were searched to identify studies published between January, 1980 and December, 2016...
May 10, 2018: Lipids in Health and Disease
https://www.readbyqxmd.com/read/29747645/biopharmaceutical-insights-of-particulate-emulsified-systems-a-prospective-overview
#15
REVIEW
Jyothshna Devi Katamreddy, Prasanna Raju Yalavarthi, Subba Rao D, Sowjanya Battu, Jaya Preethi Peesa
During the twenty-first century, drug discovery is expanding rapidly and a large number of chemical moieties are recognized. Many of them are poorly soluble and hence related biopharmaceutical constraints are to be addressed systematically. Among novel approaches to resolving biopharmaceutical issues, micro- and nano-emulsified systems serve as the best strategy for delivering both hydrophobic and hydrophilic drugs owing to their greater solubilization and transportation capabilities. Of late, the unique physical and biopharmaceutical properties of these liquid isotropic homogenous systems have gained substantive research importance...
May 10, 2018: Lipids in Health and Disease
https://www.readbyqxmd.com/read/29747638/relations-of-lipid-parameters-other-variables-with-carotid-intima-media-thickness-and-plaque-in-the-general-chinese-adults-an-observational-study
#16
Qingtao Hou, Sheyu Li, Yun Gao, Haoming Tian
BACKGROUND: It has been reported that non-high-density lipoprotein cholesterol (non-HDL-C) and lipid ratios, including total cholesterol (TC) / high-density lipoprotein cholesterol (HDL-C) and low-density lipoprotein cholesterol (LDL-C) / HDL-C, are better predictors for atherosclerosis than conventional lipid profiles. However, there have been few studies comparing the predictive values of different lipid parameters for early atherosclerosis. The aim of this study was to determine the relevant factors of carotid intima-media thickness (IMT) and plaque in the general Chinese adults and analyze the predictive values of different lipid parameters for carotid IMT and plaque...
May 10, 2018: Lipids in Health and Disease
https://www.readbyqxmd.com/read/29743087/untargeted-metabolomic-on-urine-samples-after-%C3%AE-lipoic-acid-and-or-eicosapentaenoic-acid-supplementation-in-healthy-overweight-obese-women
#17
Ana Romo-Hualde, Ana E Huerta, Carlos J González-Navarro, Omar Ramos-López, María J Moreno-Aliaga, J Alfredo Martínez
BACKGROUND: Eicosapentaenoic acid (EPA) and α-lipoic acid (α-LA) have been investigated for their beneficial effects on obesity and cardiovascular risk factors. In the current research, the goal was to evaluate metabolomic changes following the dietary supplementation of these two lipids, alone or combined in healthy overweight/obese sedentary women following an energy-restricted diet. For this purpose, an untargeted metabolomics approach was conducted on urine samples using liquid chromatography coupled with time of flight mass spectrometry (HPLC-TOF-MS)...
May 9, 2018: Lipids in Health and Disease
https://www.readbyqxmd.com/read/29743072/usefulness-of-circuit-training-at-home-for-improving-bone-mass-and-muscle-mass-while-losing-fat-mass-in-undergraduate-female-students
#18
Yoko Takahata
BACKGROUND: The purpose of this study was to determine whether or not circuit training at home affects the calcaneus quantitative ultrasound status as well as other indices of body composition among undergraduate female students. METHODS: Forty-one adolescents were recruited (18.5 ± 0.6 years old). The stiffness index of the calcaneus, broadband ultrasound attenuation of the calcaneus, speed of sound of the calcaneus, and body frame index. This was a three-month intervention study, so the measurements were conducted at baseline, 2 months later, and 3 months later while the subjects underwent circuit training at home...
May 9, 2018: Lipids in Health and Disease
https://www.readbyqxmd.com/read/29739462/effect-of-hyperlipidemia-on-the-incidence-of-cardio-cerebrovascular-events-in-patients-with-type-2-diabetes
#19
Dabei Fan, Li Li, Zhizhen Li, Ying Zhang, Xiaojun Ma, Lina Wu, Guijun Qin
BACKGROUND: This study was to explore the effect of hyperlipidemia on the incidence of cardio-cerebrovascular diseases in patients with type 2 diabetes. METHODS: Three hundred ninety five patients with type 2 diabetes in our hospital from January 2012 to January 2016 were followed up with an average of 3.8 years. The incidence of cardio-cerebrovascular diseases between diabetes combined with hyperlipidemia group (195 patients) and diabetes group (200 patients) were made a comparison...
May 8, 2018: Lipids in Health and Disease
https://www.readbyqxmd.com/read/29734946/positively-increased-visceral-adiposity-index-in-hyperuricemia-free-of-metabolic-syndrome
#20
Dongfeng Gu, Yanan Ding, Yunfeng Zhao, Shuzhai Miao, Qingshan Qu
BACKGROUND: Visceral adiposity index (VAI) was closely associated with metabolic syndrome, however almost no research focused on VAI and hyperuricemia, therefore, this study was conducted to determine the relationship of VAI and hyperuricemia free of metabolic syndrome and estimate the power of VAI as predictor for hyperuricemia. METHODS: A cross-sectional research coming from a health check-up program was conducted. All participants were divided into four groups according to VAI quartiles...
May 7, 2018: Lipids in Health and Disease
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