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Lipids in Health and Disease

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https://www.readbyqxmd.com/read/28320416/effect-of-the-r92h-and-a379v-genotypes-of-platelet-activating-factor-acetylhydrolase-on-its-enzyme-activity-oxidative-stress-and-metabolic-profile-in-chinese-women-with-polycystic-ovary-syndrome
#1
Renjiao Zhang, Qi Song, Hongwei Liu, Huai Bai, Yujin Zhang, Qingqing Liu, Linbo Guan, Ping Fan
BACKGROUND: The G994T polymorphism in platelet-activating factor acetylhydrolase (PAF-AH) gene is associated with the risk of polycystic ovary syndrome (PCOS). The aim of this study was to investigate the relationship between R92H and A379V variants of the PAF-AH gene and the risk of PCOS and to evaluate the effects of the genotypes on PAF-AH activities and clinical, metabolic and oxidative stress indexes in Chinese women. METHODS: A total of 862 patients with PCOS based on the Rotterdam consensus criteria and 750 control women from a population of Chinese Han nationality in the Chengdu area were studied from 2006-2015...
March 20, 2017: Lipids in Health and Disease
https://www.readbyqxmd.com/read/28302129/cholesterol-lowing-effect-of-taurine-in-hepg2-cell
#2
Junxia Guo, Ya Gao, Xuelian Cao, Jing Zhang, Wen Chen
BACKGROUND: A number of studies indicate that taurine promotes cholesterol conversion to bile acids by upregulating CYP7A1 gene expression. Few in vitro studies are concerned the concentration change of cholesterol and its product of bile acids, and the molecular mechanism of CYP7A1 induction by taurine. METHODS: The levels of intracellular total cholesterol (TC), free cholesterol (FC), cholesterol ester (EC), total bile acids (TBA) and medium TBA were determined after HepG2 cells were cultured for 24/48 h in DMEM supplemented with taurine at the final concentrations of 1/10/20 mM respectively...
March 16, 2017: Lipids in Health and Disease
https://www.readbyqxmd.com/read/28302123/relationship-between-non-high-density-lipoprotein-cholesterol-and-carotid-atherosclerosis-in-normotensive-and-euglycemic-chinese-middle-aged-and-elderly-adults
#3
Hui Ma, Huandong Lin, Yu Hu, Xiaoming Li, Wanyuan He, Xuejuan Jin, Jian Gao, Naiqing Zhao, Boshen Pan, Xin Gao
BACKGROUND: We investigate whether non-high-density lipoprotein cholesterol (non-HDL-C) provides a better estimate of cardiovascular risk than other lipid profiles in normotensive and euglycemic middle-aged and elderly adults. METHODS: A total of 512 males and 958 females were enrolled from the Changfeng Study. A standard interview, anthropometric measurements and laboratory analyses were performed for each participant. Bilateral carotid intima-media thicknesses (CIMTs) were measured using ultrasonography, and the presence of carotid plaques was assessed...
March 16, 2017: Lipids in Health and Disease
https://www.readbyqxmd.com/read/28288621/relationship-between-plasma-homocysteine-level-and-lipid-profiles-in-a-community-based-chinese-population
#4
Mohetaboer Momin, Jia Jia, Fangfang Fan, Jianping Li, Jingtao Dou, Dafang Chen, Yong Huo, Yan Zhang
BACKGROUND: Previous studies established a possible link among hyperhomocysteinemia (HHcy), dyslipidemia, and atherosclerosis. However, there was limited epidemic data concerning the relation between HHcy and lipid profiles, especially in community-based Chinese populations. This study aim to investigate the association of plasma homocysteine (Hcy) level with lipid profiles in a Chinese community-based population without lipid-lowering treatment. METHOD: A total of 4660 Chinese subjects from a cohort of the Shijingshan district in Beijing were included in the analysis...
March 14, 2017: Lipids in Health and Disease
https://www.readbyqxmd.com/read/28288631/effects-of-simvastatin-on-serum-adiponectin-a-meta-analysis-of-randomized-controlled-trials
#5
Weibin Chen, Zhuo Huang, Minghui Bi, Xuejing Xu, Nengjiang Zhao
BACKGROUND: Effects of simvastatin on serum level of adiponectin, a protein conferring benefits in both cardiovascular and metabolic system, are not fully determined. METHODS: A meta-analysis of randomized controlled trials (RCTs) was performed. Studies were identified by searching of Pubmed, Embase, and the Cochrane Library databases. Heterogeneity among the RCTs was determined by Cochrane's Q test and I(2) statistics. Meta-analysis was performed with random-effect model or fixed-effect model according to the heterogeneity...
March 13, 2017: Lipids in Health and Disease
https://www.readbyqxmd.com/read/28274232/perilipin-polymorphisms-are-risk-factors-for-the-development-of-obesity-in-adolescents-a-case-control-study
#6
Yavuz Tokgöz, Ishak Abdurrahman Işık, Soheil Akbari, Tuncay Kume, Oya Sayın, Esra Erdal, Nur Arslan
BACKGROUND: The variations in perilipin gene (PLIN) were previously associated with obesity. We examined the association of polymorphisms at the PLIN locus in adolescents with obesity and their connection with serum adipokines. METHODS: A total of 308 children (206 obese, 66.8% and 102 healthy control, 33.2%) between the ages of 10-18 years were included into the study. PLIN gene analysis [PLIN 1, PLIN 4, PLIN 6, PLIN 5'UTR-1234 C > G and PLIN 10171 A/T] were studied by Real Time-PCR...
March 9, 2017: Lipids in Health and Disease
https://www.readbyqxmd.com/read/28249586/serum-lipid-profile-as-a-marker-of-liver-impairment-in-hepatitis-b-cirrhosis-patients
#7
Sadia Qamar Arain, Farah Naz Talpur, Naseem Aslam Channa, Muhammad Shahbaz Ali, Hassan Imran Afridi
BACKGROUND: Chronic HBV infection is a major cause of Cirrhosis and an important risk factor to develop hepatocellular carcinoma. The study is conducted to find out the changes in the lipid metabolism of HBV-cirrhosis patients. METHODS: In the present study, serum lipid profiles of patients with HBV-cirrhosis were assessed by utilizing micro-lab and gas chromatography, while risk factors for transmission of HBV-cirrhosis studied through the standard questionnaire...
March 1, 2017: Lipids in Health and Disease
https://www.readbyqxmd.com/read/28245873/effect-of-two-lipid-lowering-strategies-on-high-density-lipoprotein-function-and-some-hdl-related-proteins-a-randomized-clinical-trial
#8
Chan Joo Lee, Seungbum Choi, Dong Huey Cheon, Kyeong Yeon Kim, Eun Jeong Cheon, Soo-Jin Ann, Hye-Min Noh, Sungha Park, Seok-Min Kang, Donghoon Choi, Ji Eun Lee, Sang-Hak Lee
BACKGROUND: The influence of lipid-lowering therapy on high-density lipoprotein (HDL) is incompletely understood. We compared the effect of two lipid-lowering strategies on HDL functions and identified some HDL-related proteins. METHODS: Thirty two patients were initially screened and HDLs of 21 patients were finally analyzed. Patients were randomized to receive atorvastatin 20 mg (n = 11) or atorvastatin 5 mg/ezetimibe 10 mg combination (n = 10) for 8 weeks...
February 28, 2017: Lipids in Health and Disease
https://www.readbyqxmd.com/read/28245847/relationship-between-coping-styles-and-lipid-profile-among-public-university-staff
#9
Suthahar Ariaratnam, Ambigga Devi Krishnapillai, Aqil Mohammad Daher, Mohd Ariff Fadzil, Salmi Razali, Siti Aminah Omar, Ng Kien Keat, Nafiza Mat Nasir, Maizatullifah Miskan, Mazapuspavina Md Yasin, Jo Anne Saw, Damayanthi Durairajanayagam, Gurpreet Kaur, Osman Che Bakar, Nurul Azreen Hashim
BACKGROUND: The scarcity of data about coping styles with a biochemical marker namely lipid profile, potentially associated with cardiovascular risk factors is most striking among professionals working in public university. Hence, this research aimed to investigate the relationship between coping styles and lipid profile comprising total cholesterol (TC), triglyceride (TG), HDL-cholesterol (high density lipoprotein-cholesterol) and LDL-cholesterol (Low density lipoprotein-cholesterol) among this group of professionals...
February 28, 2017: Lipids in Health and Disease
https://www.readbyqxmd.com/read/28241772/association-between-low-density-lipoprotein-cholesterol-and-occipital-periventricular-hyperintensities-in-a-group-of-chinese-patients-an-observational-study
#10
Dazhi Duan, Lin Shen, Chun Cui, Tongsheng Shu, Jian Zheng
BACKGROUND: While occipital periventricular hyperintensities (OPVHs) are among the most common mild white matter hyperintensities, the clinical factors associated with OPVHs remain unclear. In this study, we investigated the role of clinical factors in development of pure OPVHs. METHODS: This study included 97 patients with OPVHs and 73 healthy controls. Univariate analysis of clinical factors in OPVH patients and controls was followed by binomial logistic regression analysis to identify clinical factors significantly associated with OPVHs...
February 27, 2017: Lipids in Health and Disease
https://www.readbyqxmd.com/read/28231818/histomorphology-ultrastructure-and-fatty-acid-composition-of-the-adipose-tissue-in-pansteatitis-the-potentials-in-understanding-the-underlying-mechanism-and-diagnosis-of-pansteatitis-in-the-nile-crocodile
#11
O I Azeez, J G Myburgh, R A Meintjes, M C Oosthuizen, J P Chamunorwa
BACKGROUND: In an effort to characterize the fat body and other adipose tissue in the Nile crocodile and the effects of pansteatitis on the structure and composition of the adipose tissue, we evaluated the regional variation in structure and fatty acid composition of healthy farmed crocodiles and those affected by pansteatitis. METHODS: Adipose tissue samples were collected from the subcutaneous, visceral and intramuscular fat and the abdominal fat body of ten 4-year old juvenile crocodiles from Izinthaba Crocodile Farm, Pretoria, South Africa while pansteatitis samples were collected from visceral and intramuscular fat of crocodiles that had died of pansteatitis at the Olifant River, Mpumalanga, also in South Africa...
February 23, 2017: Lipids in Health and Disease
https://www.readbyqxmd.com/read/28231800/dietary-intervention-but-not-losartan-completely-reverses-non-alcoholic-steatohepatitis-in-obese-and-insulin-resistant-mice
#12
Jef Verbeek, Pieter Spincemaille, Ilse Vanhorebeek, Greet Van den Berghe, Ingrid Vander Elst, Petra Windmolders, Jos van Pelt, Schalk van der Merwe, Pierre Bedossa, Frederik Nevens, Bruno Cammue, Karin Thevissen, David Cassiman
BACKGROUND: Dietary intervention is the cornerstone of non-alcoholic steatohepatitis (NASH) treatment. However, histological evidence of its efficacy is limited and its impact on hepatic pathways involved in NASH is underreported. The efficacy of the angiotensin receptor type 1 blocker losartan is controversial because of varying results in a few animal and human studies. We evaluated the effect of dietary intervention versus losartan on NASH and associated systemic metabolic features in a representative mouse model...
February 23, 2017: Lipids in Health and Disease
https://www.readbyqxmd.com/read/28228158/flaxseed-oil-ameliorates-alcoholic-liver-disease-via-anti-inflammation-and-modulating-gut-microbiota-in-mice
#13
Xiaoxia Zhang, Hao Wang, Peipei Yin, Hang Fan, Liwei Sun, Yujun Liu
BACKGROUND: Alcoholic liver disease (ALD) represents a chronic wide-spectrum of liver injury caused by consistently excessive alcohol intake. Few satisfactory advances have been made in management of ALD. Thus, novel and more practical treatment options are urgently needed. Flaxseed oil (FO) is rich in α-linolenic acid (ALA), a plant-derived n-3 polyunsaturated fatty acids (PUFAs). However, the impact of dietary FO on chronic alcohol consumption remains unknown. METHODS: In this study, we assessed possible effects of dietary FO on attenuation of ALD and associated mechanisms in mice...
February 22, 2017: Lipids in Health and Disease
https://www.readbyqxmd.com/read/28228137/erratum-to-randomized-double-blind-clinical-trial-on-the-effect-of-oral-%C3%AE-cyclodextrin-on-serum-lipids
#14
Marcelo J A Amar, Maryann Kaler, Amber B Courville, Robert Shamburek, Maureen Sampson, Anna Wolska, Alan T Remaley
No abstract text is available yet for this article.
February 22, 2017: Lipids in Health and Disease
https://www.readbyqxmd.com/read/28219431/assessment-of-triglyceride-and-cholesterol-in-overweight-people-based-on-multiple-linear-regression-and-artificial-intelligence-model
#15
Jing Ma, Jiong Yu, Guangshu Hao, Dan Wang, Yanni Sun, Jianxin Lu, Hongcui Cao, Feiyan Lin
BACKGROUND: The prevalence of high hyperlipemia is increasing around the world. Our aims are to analyze the relationship of triglyceride (TG) and cholesterol (TC) with indexes of liver function and kidney function, and to develop a prediction model of TG, TC in overweight people. METHODS: A total of 302 adult healthy subjects and 273 overweight subjects were enrolled in this study. The levels of fasting indexes of TG (fs-TG), TC (fs-TC), blood glucose, liver function, and kidney function were measured and analyzed by correlation analysis and multiple linear regression (MRL)...
February 20, 2017: Lipids in Health and Disease
https://www.readbyqxmd.com/read/28219380/effects-of-nutritional-conditions-on-growth-and-biochemical-composition-of-tetraselmis-sp
#16
Mouna Dammak, Bilel Hadrich, Ramzi Miladi, Mohamed Barkallah, Faiez Hentati, Ridha Hachicha, Céline Laroche, Philippe Michaud, Imen Fendri, Slim Abdelkafi
BACKGROUND: This study aimed to maximize biomass concentration, biomass productivity and biochemical composition of the marine microalga Tetraselmis sp. METHODS: In the current study, Box-Behnken Design was used to model the effect of NaNO3, NaH2PO4, metals and vitamins in the F/2 medium on the growth, total chlorophylls, carotenoids and starch contents. The total chlorophylls content was quantified by spectrophotometry. The FT-IR spectroscopy was used to estimate the biochemical compositions of Tetraselmis sp...
February 20, 2017: Lipids in Health and Disease
https://www.readbyqxmd.com/read/28219371/erratum-to-camel-milk-peptide-improves-wound-healing-in-diabetic-rats-by-orchestrating-the-redox-status-and-immune-response
#17
Hossam Ebaid, Bahaa Abdel-Salam, Iftekhar Hassan, Jameel Al-Tamimi, Ali Metwalli, Ibrahim Alhazza
No abstract text is available yet for this article.
February 20, 2017: Lipids in Health and Disease
https://www.readbyqxmd.com/read/28209162/fatty-acid-and-cholesterol-profiles-hypocholesterolemic-atherogenic-and-thrombogenic-indices-of-broiler-meat-in-the-retail-market
#18
Youssef A Attia, Mohammed A Al-Harthi, Mohamed A Korish, Mohamed M Shiboob
BACKGROUND: Broiler meat is an essential source of food due to its favourable effects on human health derived from its protein, fats, minerals, vitamins and its bioactive components. METHODS: A total of 90 carcasses were collected from the retail market in Jeddah city, Saudi Arabia during April, May and June 2014 to determine the effects of meat type (frozen vs. fresh) and sources within fresh types (A, B, C) vs. frozen types (D, E and F) on their fatty acid profiles, cholesterol, their hypocholesterolemic, atherogenic and thrombogenic indices, and on their antioxidants' status...
February 16, 2017: Lipids in Health and Disease
https://www.readbyqxmd.com/read/28187765/does-a-lack-of-physical-activity-explain-the-rheumatoid-arthritis-lipid-profile
#19
Hiba AbouAssi, Margery A Connelly, Lori A Bateman, K Noelle Tune, Janet L Huebner, Virginia B Kraus, Deborah A Winegar, James D Otvos, William E Kraus, Kim M Huffman
BACKGROUND: In rheumatoid arthritis (RA), cardiovascular risk is associated with paradoxical reductions in total cholesterol, low density lipoprotein-cholesterol (LDL-C), and high density lipoprotein-cholesterol (HDL-C). Concentrations of small LDL (LDL-P) and HDL (HDL-P) particles are also reduced with increased inflammation and disease activity in RA patients. Here we sought to identify which measure(s) of inflammation, disease activity and cardiometabolic risk contribute most to the RA-associated lipoprotein profile...
February 10, 2017: Lipids in Health and Disease
https://www.readbyqxmd.com/read/28183305/controlling-of-growth-performance-lipid-deposits-and-fatty-acid-composition-of-chicken-meat-through-a-probiotic-lactobacillus-johnsonii-during-subclinical-clostridium-perfringens-infection
#20
Hesong Wang, Xueqin Ni, Lei Liu, Dong Zeng, Jing Lai, Xiaodan Qing, Guangyao Li, Kangcheng Pan, Bo Jing
BACKGROUND: Meat is considered as a major source of polyunsaturated fatty acid (PUFA) which is essential for humans, therefore its lipid level and fatty acid composition have drawn great attention. As no clinical sign can be found in chicks subclinically infected by Clostridium perfringens (CP), the meat may be purchased and eaten. The objective of the present study was to determine whether Lactobacillus johnsonii (LJ) can control the CP-caused impact on growth, lipid levels, fatty acid composition and other flavor or nutritional quality in the meat...
February 10, 2017: Lipids in Health and Disease
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