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Lipids in Health and Disease

Päivi Hämäläinen, Juha Saltevo, Hannu Kautiainen, Pekka Mäntyselkä, Mauno Vanhala
BACKGROUND: Alterations in lipoprotein size are associated with increased cardiovascular disease risk. Higher hemoglobin levels may indicate a higher risk of atherosclerosis and was previously associated with obesity, metabolic syndrome, and insulin resistance. No previous studies have investigated an association between hemoglobin concentration and lipoprotein particle size. METHODS: We conducted a population-based, cross-sectional study of 766 Caucasian, middle-aged subjects (341 men and 425 women) born in Pieksämäki, Finland, who were categorized into five age groups...
January 10, 2018: Lipids in Health and Disease
Khaled Bellassoued, Anis Ben Hsouna, Khaled Athmouni, Jos van Pelt, Fatma Makni Ayadi, Tarek Rebai, Abdelfattah Elfeki
BACKGROUND: Mentha piperita L. is a flowering plant belonging to the Lamiaceae family. Mentha plants constitute one of the main valuable sources of essential oil used in foods and for medicinal purposes. METHODS: The present study aimed to investigate the composition and in vitro antioxidant activity of Mentha piperita leaf essential oil (MpEO). A single dose of CCl4 was used to induce oxidative stress in rats, which was demonstrated by a significant rise of serum enzyme markers...
January 9, 2018: Lipids in Health and Disease
Kristin K Clemens, Salimah Z Shariff, Eric McArthur, Robert A Hegele
BACKGROUND: The utility of ezetimibe in preventing cardiovascular outcomes remains controversial. To guide future assessments of the effectiveness of ezetimibe in routine care, we evaluated how this medication has been prescribed to high-risk older adults in Ontario, Canada. METHODS: Using linked healthcare databases, we carried out a population-based cohort study of older adults who were discharged from hospital following an acute myocardial infarction from 2005 until 2014...
January 8, 2018: Lipids in Health and Disease
Meng-Yun Cai, Jie Cheng, Meng-Yuan Zhou, Li-Li Liang, Si-Min Lian, Xiao-Shan Xie, Shun Xu, Xinguang Liu, Xing-Dong Xiong
BACKGROUND: Accumulating evidences have shown that miRNAs are directly or indirectly involved in a variety of biological processes, and closely associated with diverse human diseases, including cardiovascular diseases. SNPs locating within pri/pre-miRNA can affect miRNA processing and binding ability of target genes. MiR-27a, miR-26a-1 miR-100, miR-126 and miR-218 were reported to be associated with pathogenesis of myocardial infarction (MI). Here we aimed to evaluate the potential association of five polymorphisms in these pri/pre-miRNAs with individual susceptibility to MI in a Chinese Han population...
January 6, 2018: Lipids in Health and Disease
Fan Wang, Xiaona Wang, Ping Ye, Ruihua Cao, Yun Zhang, Yue Qi, Dong Zhao
BACKGROUND: Although drug trials with niacin and cholesteryl ester transfer protein inhibitors that substantially increase high-density lipoprotein-cholesterol (HDL-C) failed to reduce the risk of coronary heart disease, HDL protection of the cardiovascular system cannot be easily denied. Hence, it may be HDL subfractions that are responsible for the long-held and consistent cardioprotective association of HDL. Arterial stiffness has been increasingly recognized as a strong predictor of subclinical vascular disease, atherosclerotic disease, and cardiovascular mortality...
January 5, 2018: Lipids in Health and Disease
Saleem Ullah Shahid, Shabana, Steve Humphries
BACKGROUND: rs10911021 (a single nucleotide polymorphism present upstream of the GLUL gene) affects glutamic acid metabolism, and was shown to be associated with coronary heart disease (CHD) in patients with T2DM but a definite mechanism is unknown. It may affect glutathione cycle, an important effector in the antioxidant defense mechanism, in the cells. We checked the association of this SNP with CHD and oxidative stress biomarkers, malondialdeheyde (MDA), GSH and GSSG in Pakistani patients...
January 5, 2018: Lipids in Health and Disease
Yan Li, Zhen Chen, Hejian Song
BACKGROUND: The KIF6 rs20455 polymorphism has been verified as an important genetic factor of coronary heart disease (CHD), but with controversial results. The aim of this study was to explore the association between KIF6 rs20455 polymorphism and susceptibility to CHD. METHODS: All eligible studies were identified by searching Medline (mainly PubMed), EMBASE, the Web of Science, Cochrane Collaboration Database, Chinese National Knowledge Infrastructure, Wanfang Database and China Biological Medicine up to October 5, 2016...
January 5, 2018: Lipids in Health and Disease
Lulu Zhang, Yingfen Qin, Danyan Liang, Li Li, Yaojie Liang, Lulin Chen, Lei Tong, Jia Zhou, Hong Li, Haiying Zhang
BACKGROUND: Leptin acts as a mediator of inflammation and energy homeostasis by activating leptin receptor (LEPR). We conducted this study to explore the association of polymorphisms in LEPR with type 2 diabetes mellitus (T2DM) and its related metabolic traits. METHODS: We performed a case-control study to investigate the association of polymorphisms in LEPR with T2DM and related metabolic traits in a Chinese population, with a total of 922 T2DM patients and 1031 nondiabetic subjects...
January 4, 2018: Lipids in Health and Disease
Qinyuan Xu, Sijia Cao, Sanjeeva Rajapakse, Joanne A Matsubara
RATIONALE: Age-related macular degeneration (AMD) is one of the leading causes of blindness among the elderly. Due to its complex etiology, current treatments have been insufficient. Previous studies reveal three systems closely involved in AMD pathogenesis: lipid metabolism, oxidation and inflammation. These systems are also involved in Alzheimer's disease, atherosclerosis and glomerulonephritis. Understanding commonalities of these four diseases may provide insight into AMD etiology...
January 4, 2018: Lipids in Health and Disease
Barry T Radler, Attilio Rigotti, Carol D Ryff
BACKGROUND: Psychological correlates of blood lipid levels have been previously evaluated mostly in cross sectional studies. However, prospectively measured psychological factors might also predict favorable blood lipid profiles, thereby indicating a healthy mind/body interplay that is associated with less disease, better health and longer lives. METHODS: This paper examined whether longitudinal profiles of psychological well-being over 9-10 years are predictors of blood lipid profiles...
January 3, 2018: Lipids in Health and Disease
Mohsen Mazidi, Nathan D Wong, Niki Katsiki, Dimitri P Mikhailidis, Maciej Banach
BACKGROUND: To investigate the association between dietary patterns (DP), plasma vitamins and trans fatty acids (TFAs) with the likelihood of peripheral artery disease (PAD). METHODS: National Health and Nutrition Examination Survey (NHANES) data for the years 1999-2002 were used. PAD was diagnosed by ankle brachial index assessment. Plasma concentrations of vitamins were measured using high performance liquid chromatography. Vitamin D levels were measured by radioimmunoassay...
December 28, 2017: Lipids in Health and Disease
Tian Shen, Guoqiang Xing, Jingfen Zhu, Shuxian Zhang, Yong Cai, Donghua Li, Gang Xu, Evan Xing, Jianyu Rao, Rong Shi
BACKGROUNDS: To study the effects of supplementation of a marine omega-3 poly-unsaturated fatty acids (n3-PUFA) formulation (Omega3Q10) in older adults with hypertension and/or hypercholesterolemia. METHODS: A total of 97 people were enrolled to receive 12-week supplementation of either Omega3Q10 (n = 48) or soybean oil (n = 49). Total cholesterol (TC), low density lipoprotein cholesterol (LDL-C), high density lipoprotein cholesterol (HDL-C), and hypertension-related symptoms were determined before and after the supplementation...
December 27, 2017: Lipids in Health and Disease
Rihab Ben Abdallah Kolsi, Bochra Gargouri, Sameh Sassi, Donyez Frikha, Saloua Lassoued, Karima Belghith
BACKGROUND: During the last few decades, there has been a growing interest in the search for novel bioactive compounds from marine origins. METHODS: The present study is the first to determine the molecular characterization which it was deposited in the genebank database, to investigate and evaluate the biological properties of sulfated polysaccharide from Cymodocea nodosa (CNSP) seagrass. RESULTS: The results revealed that CNSP had high activity in total antioxidant assay (59...
December 22, 2017: Lipids in Health and Disease
Yong Cai, Guoqiang Xing, Tian Shen, Shuxian Zhang, Jianyu Rao, Rong Shi
BACKGROUNDS: Recent experiments suggest that Citrus bergamia extracts could benefit people with dyslipidemia and obesity but this needs to be further validated. METHODS: A total of 98 people age-matched older adults (65 years) with elevated blood lipids were enrolled to receive 12-week supplementation of a Citrus bergamia extracts-based formulation (CitriCholess)(n = 48) and placebo (n = 50). RESULTS: No group differences were found in baseline bodyweight, body mass index (BMI), blood cholesterol (TC), triglycerides (TG), low density lipoprotein cholesterol (LDL-C) and glucose levels...
December 22, 2017: Lipids in Health and Disease
Helena Gbelcová, Silvie Rimpelová, Zdeněk Knejzlík, Jana Šáchová, Michal Kolář, Hynek Strnad, Vanda Repiská, Walter Cosimo D'Acunto, Tomáš Ruml, Libor Vítek
BACKGROUND: Statin treatment of hypercholesterolemia is accompanied also with depletion of the mevalonate intermediates, including farnesyl pyrophosphate (FPP) and geranylgeranyl pyrophosphate (GGPP) necessary for proper function of small GTPases. These include Ras proteins, prevalently mutated in pancreatic cancer. In our study, we evaluated the effect of three key intermediates of the mevalonate pathway on GFP-K-Ras protein localization and the gene expression profile in pancreatic cancer cells after exposure to individual statins...
December 20, 2017: Lipids in Health and Disease
Djeyne Silveira Wagmacker, Jefferson Petto, Amanda Silva Fraga, Jackeline Barbosa Matias, Sindy Kerole Andrade Mota, Luiz Erlon Araujo Rodrigues, Ana Marice Ladeia
BACKGROUND: There are various factors that influence the effect of physical exercise on the lipid profile, among them the body mass index and calorie expenditure of the exercise are some of the main factors. To test the hypothesis that a physical exercise session based on caloric expenditure may acutely modify the glycemia and lipid values of women with excess body mass. METHODS: The study included 66 women, randomly divided into two groups, control and experimental, with BMI of 29 ± 4...
December 19, 2017: Lipids in Health and Disease
Miso Kang, Ayoung Lee, Hye Jin Yoo, Minjoo Kim, Minkyung Kim, Dong Yeob Shin, Jong Ho Lee
BACKGROUND: Visceral fat accumulation in overweight status has been resulted in changes of fatty acid profiles. The fatty acids profiles can be altered by fatty acid desaturase; the activity of which is highly associated with obesity and other metabolic diseases. We hypothesized that fatty acid composition, desaturase activity, and accumulation of visceral fat are interrelated. Thus, the aim of this study was to investigate the association between increased visceral fat area and alterations in plasma fatty acid profile in overweight subjects with different amounts of visceral fat...
December 19, 2017: Lipids in Health and Disease
Maryam Ebadi, Catherine J Field, Richard Lehner, Vera C Mazurak
BACKGROUND: Accelerated loss of adipose tissue in cancer is associated with shorter survival, and reduced quality of life. Evidence is emerging suggesting tumour association with alterations in adipose tissue, but much less is known about drug-related mechanisms contributing to adipose atrophy. Identification of mechanisms by which tumour and cancer treatments, such as chemotherapy, affect adipose tissue are required to develop appropriate therapeutic interventions to prevent fat depletion in cancer...
December 19, 2017: Lipids in Health and Disease
Luzia S Sampaio, Paulo A da Silva, Valdilene S Ribeiro, Carmem Castro-Chaves, Lucienne S Lara, Adalberto Vieyra, M Einicker-Lamas
BACKGROUND: Undernutrition during childhood leads to chronic diseases in adult life including hypertension, diabetes and chronic kidney disease. Here we explore the hypothesis that physiological alterations in the bioactive lipids pattern within kidney tissue might be involved in the progression of chronic kidney disease. METHODS: Membrane fractions from kidney homogenates of undernourished rats (RBD) were submitted to lipid extraction and analysis by thin layer chromatography and cholesterol determination...
December 16, 2017: Lipids in Health and Disease
Zhixiong Zhong, Jing Liu, Bing Li, Cunren Li, Zhidong Liu, Min Yang, Qifeng Zhang, Wei Zhong, Pingsen Zhao
BACKGROUND: Little is known about serum lipid levels comparison of patients with acute myocardial infarction (AMI) in Hakka patients in southern China. To estimate the prevalence lipid profiles in Hakka patients with AMI in southern China. METHOD: We analyzed 1382 patients with a first AMI in Hakka patients in southern China between Jan. 2015 and Dec. 2015. RESULTS: Our findings demonstrated that low-density lipoprotein cholesterol (LDL), total cholesterol (TC), and triglyceride (TG) were higher in nonelderly than in elderly for males...
December 16, 2017: Lipids in Health and Disease
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