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Lipids in Health and Disease

Liangcai Gao, Zejie Lin, Yilian Liu, Xinyi Wang, Linlin Wan, Liuliu Zhang, Xinnan Liu
BACKGROUND: Fragarianilgerrensis Schlecht. medicine compound (FN-MC) is a kind of Chinese herbs' compound consisted of Fragarianilgerrensis Schlecht. and Centella asiatica (L.) Urban. The study was to investigate the hypolipidemia effect of FN-MC in a hypolipidemic rat model. METHODS: Male SD rats were randomly divided into five groups: normal-fat diet (NFD) group, high-fat diet (HFD) group, FN-MC (2 g/Kg) group, FN-MC (4 g/Kg) group and simvastatin (PDC) group...
September 19, 2018: Lipids in Health and Disease
Fang Liu, Hui Zhou, Lei Cao, Zhirong Guo, Chen Dong, Lugang Yu, Yiying Wang, Chunxing Liu, Jing Qiu, Yong Xue, Xingxiang Liu, Yunfang Xu
BACKGROUND: The production of peripheral platelet is mainly regulated by thrombopoietin, which is a glycoprotein hormone predominantly synthesized in the liver. Previously, many studies have reported that there was an inverse correlation between the degree of chronic viral hepatitis and the peripheral platelet count. However, the effect of nonalcoholic fatty liver disease (NAFLD) on the peripheral platelet counts remains unclear. METHODS: With 1303 participants from "The prevention of MS and multi-metabolic disorders in Jiangsu province of China (PMMJS)" cohort study, we investigated the associations between NAFLD and the risk of platelet counts reduction in Chinese adults...
September 19, 2018: Lipids in Health and Disease
Han Yingchun, Ma Yahong, Wen Jiangping, He Xiaokui, Zhang Xiaohong
BACKGROUND: Overexpression of apolipoprotein CIII (ApoCIII) leads to hypertriglyceridemia (HTG) which promotes atherosclerosis development. However, it remains unclear whether ApoCIII affects the atherosclerosis alone by promoting the inflammation and endoplasmic reticulum (ER) stress, or in combination with HTG. METHODS: Transgenic (ApoCIIItg) mouse models were used to investigate the atherogenic role of ApoCIII. Since endothelial cells and macrophages play crucial roles in atherosclerosis, we examined whether triglyceride-rich lipoproteins (TRLs), the major lipoproteins, in plasma of ApoCIIItg mice affect inflammation and ER stress levels in these cells...
September 17, 2018: Lipids in Health and Disease
Mohsen Mazidi, Niki Katsiki, Andre Pascal Kengne, Dimitri P Mikhailidis, Maciej Banach
BACKGROUND: Growing evidence suggests an inverse association between whole grain (WG) consumption and insulin resistance (IR) or inflammation. However, it is still unclear whether adiposity plays a role in this relationship. We investigated whether the associations between WG intake with IR, glucose homeostasis and inflammation are mediated by adiposity in US adults. METHODS: The 2005-2010 National Health and Nutrition Examination Surveys participants were included...
September 17, 2018: Lipids in Health and Disease
Olga Gruzdeva, Daria Borodkina, Evgenya Uchasova, Yulia Dyleva, Olga Barbarash
Despite the existing preventative and therapeutic measures, cardiovascular diseases remain the main cause of temporary disability, long-term disability, and mortality. Obesity is a major risk factor for cardiovascular diseases and their complications. However, not all fat depots have the same inflammatory, paracrine, and metabolic activities. In addition, recent studies have indicated that the accumulation of visceral fat, rather than subcutaneous fat, is associated with increased cardiometabolic risk. However, there is also evidence that increasing the area of visceral fat can help protect against lipotoxicity...
September 15, 2018: Lipids in Health and Disease
Natalia Wasilewska, Anna Bobrus-Chociej, Ewa Harasim-Symbor, Eugeniusz Tarasów, Małgorzata Wojtkowska, Adrian Chabowski, Dariusz M Lebensztejn
BACKGROUND: Hepatic lipid accumulation is closely related to the development of insulin resistance, which is regarded as one of the most significant risk factors of nonalcoholic fatty liver disease (NAFLD). Although the exact molecular pathway leading to impaired insulin signaling has not been definitively established, ceramides are suspected mediators of lipid induced hepatic insulin resistance. Therefore, the aim of the study was to evaluate the serum ceramides concentration in obese children with NAFLD...
September 12, 2018: Lipids in Health and Disease
Xuemei Zhang, Zhaowei Meng, Xue Li, Ming Liu, Xiaojun Ren, Mei Zhu, Qing He, Qing Zhang, Kun Song, Qiyu Jia, Chunmei Zhang, Xiaoran Wang, Xiangxiang Liu
OBJECTIVE: Dyslipidemia can cause some chronic diseases. Bilirubin is reported to have anti-inflammatory and anti-oxidant properties. We aimed to explore the relationship between triglyceride and total bilirubin (TB) in a large Chinese cohort. METHODS: A total of 80,298 healthy Chinese (48,971 male, 31,327 female) enrolled in this cross-sectional study. Clinical data were collected from participants. Database was divided according to sex and age. The relationship between triglyceride and TB was analyzed by quartiles of TB...
September 12, 2018: Lipids in Health and Disease
Jun Aikawa, Kentaro Uchida, Shotaro Takano, Gen Inoue, Dai Iwase, Masayuki Miyagi, Manabu Mukai, Shintaro Shoji, Hiroyuki Sekiguchi, Masashi Takaso
BACKGROUND: The infrapatellar fat pad (IFP) is implicated in knee osteoarthritis (KOA). Calcitonin gene-related peptide (CGRP), a vasoactive neuropeptide expressed in joint tissues and synovial tissues (ST), was recently found to be associated with KOA progression and pain. CGRP is expressed in the IFPs of human KOA patients; however, its regulation has not been elucidated. METHODS: IFPs and STs were harvested from 138 KOA patients during total knee replacement (TKR) and analyzed for CGRP, cycloxygenase-2 (COX-2), and microsomal prostaglandin E synthase-1 (mPGES-1) expression using real-time polymerase chain reaction (PCR)...
September 11, 2018: Lipids in Health and Disease
Kena Zhou, Jie Cen
BACKGROUND: Hypertension and nonalcoholic fatty liver both have been considered as the serious public health problems in recent years. However, the longitudinal association between hypertension and nonalcoholic fatty liver remains unclear in Chinese population. METHODS: This study was aimed to investigate the longitudinal association between nonalcoholic fatty liver assessed by fatty liver index and the incident hypertension among Chinese population and to evaluate the ability of FLI index, through comparing with the predictive value of other indexes...
September 11, 2018: Lipids in Health and Disease
Gaojun Cai, Lei Yu, Zhiying Huang, Li Li, Xingli Fu
BACKGROUND: Genetic and environment factors affect the occurrence and development of coronary artery disease (CAD). Proprotein convertase subtilisin/kexin type 9 (PCSK9), has been investigated extensively in the field of lipid metabolism and CAD. We performed this case-control study to investigate the relationship between serum PCSK9 levels and PCSK9 polymorphisms and lipid levels and CAD risk in a southern Chinese population. METHODS: A hospital-based case-control study with 1, 096 subjects, including 626 CAD patients and 470 controls, were conducted...
September 11, 2018: Lipids in Health and Disease
Hyungseon Yeom, Hyeon Chang Kim, Ju-Mi Lee, Yongwoo Jeon, Il Suh
BACKGROUND: The triglyceride to high density lipoprotein cholesterol (TG/HDL-C) ratio associated with hypertension in adults. However, whether the TG/HDL-C ratio in adolescents predicts future hypertension remains unclear. Here, we evaluated the prospective association between the TG/HDL-C ratio in adolescents and hypertension in early adulthood. METHODS: The Kangwha Study is an ongoing prospective cohort study that has tracked the blood pressure of first grade elementary school students since 1986...
September 10, 2018: Lipids in Health and Disease
Joshua S Brzozowski, Helen Jankowski, Danielle R Bond, Siobhan B McCague, Benjamin R Munro, Melanie J Predebon, Christopher J Scarlett, Kathryn A Skelding, Judith Weidenhofer
BACKGROUND: Extracellular vesicles (EVs) are produced and secreted from most cells of the body and can be recovered in biological fluids. Although there has been extensive characterisation of the protein and nucleic acid component of EVs, their lipidome has received little attention and may represent a unique and untapped source of biomarkers for prostate cancer diagnosis and prognosis. METHODS: EVs were isolated from non-tumourigenic (RWPE1), tumourigenic (NB26) and metastatic (PC-3) prostate cell lines...
September 8, 2018: Lipids in Health and Disease
Zhuying Wei, Dongfang Li, Lin Zhu, Lei Yang, Chen Chen, Chunling Bai, Guangpeng Li
BACKGROUND: The consumption of omega 3 polyunsaturated fatty acids (PUFAs) is important for human health and is closely associated with cell proliferation and differentiation. This study aimed to investigate the influence of omega 3 PUFAs on embryonic stem cell (ESC) proliferation and explore potential mechanisms that mediate these effects. METHODS: In this study, we isolated ESCs from fad3b-expressing transgenic mice. We detected the fatty-acid composition of ESCs using gas chromatography-mass spectroscopy, analyzed cell-cycle phases using flow cytometry, and detected gene expression using real-time polymerase chain reaction (PCR) and western blots...
September 8, 2018: Lipids in Health and Disease
Yan Wang, Jun Zhang, Yanrong Ma, Xiangxin Song, Suli Li, Xianqin Zhan, Lan Wu
BACKGROUND: This study aimed to determine the differences in clinical parameters among Han, Uygur, and Kazak men with normal glucose tolerance. METHODS: Participants' data from the China National Diabetes and Metabolic Disorders Study pertaining to Han, Uygur, and Kazak men from the Xinjiang province were used (n = 930). Pearson's correlation was used to examine the relationship between HOMA-IR, Matsuda Index, and clinical characteristics. RESULTS: HOMA-IR of Han men was significantly higher than in Uygurs and Kazaks (P < 0...
September 7, 2018: Lipids in Health and Disease
Sandra Kutkiene, Zaneta Petrulioniene, Aleksandras Laucevicius, Gabija Matuzeviciene, Vytautas Kasiulevicius, Emilija Petrulionyte, Justina Staigyte, Akvile Saulyte, Urte Gargalskaite, Egle Skiauteryte, Milda Kovaite, Egidija Rinkuniene
BACKGROUND: Atherogenic dyslipidemia (AD) is a blood serum lipid profile abnormality characterized by elevation of triglycerides and reduced levels of high density lipoprotein cholesterol (HDL-C). It is associated with residual cardiovascular risk. This study evaluated and compared the risk profiles of patients with hypertriglyceridemia, low-HDL-C levels or AD, in order to understand, which lipid profile is associated with greater risk. METHODS: During the period of 2009-2016 a population of 92,373 Lithuanian adults (men 40-54 years old and women 50-64 years old) without overt cardiovascular disease were analyzed...
September 5, 2018: Lipids in Health and Disease
Jing Zhou, Lifang Chen, Zhenjie Liu, Ling Sang, Yimin Li, Dongjuan Yuan
BACKGROUND: To investigate the changes of polyunsaturated fatty acids (PUFAs) and their downstream eicosanoids in patients with asthma, the levels of erythrocyte membrane lipids and plasma lipid metabolites were examined. METHODS: Erythrocyte membrane lipids were extracted and esterificated, and then fatty acid compositions were determined by gas chromatography. The concentrations of six eicosanoids of PGE2 , TXA2 , LTB4 , PGE1 , 6-k-PGF1α and PGF2α in plasma were measured by ELISA...
September 1, 2018: Lipids in Health and Disease
Duck-Pil Ok, Kangeun Ko, Ju Yong Bae
BACKGROUND: This study aimed to analyze the effect of exercise and/or dietary change on improvement of non-alcoholic fatty liver disease (NAFLD) in chronic high-fat diet (HFD)-induced obese mice. METHODS: Forty male C57BL/6 (8 weeks old) mice were divided into normal diet (CO, n = 8) and high-fat diet (HF, n = 32) groups. The HF group was fed with 60% fat chow for 16 weeks to induce obesity. After the obesity induction period, the HF group was subdivided into HFD + sedentary (n = 8), HFD + training (HFT, n = 8), dietary change to normal-diet + sedentary (HFND, n = 8), and dietary change to normal-diet + training (HFNDT, n = 8) groups, and the mice in the training groups underwent treadmill training for 8 weeks, 5 times per week, 40 min per day...
September 1, 2018: Lipids in Health and Disease
Hanan Alfawaz, Ramesa Shafi Bhat, Manar Al-Mutairi, Osima M Alnakhli, Abeer Al-Dbass, Mona AlOnazi, Majidh Al-Mrshoud, Iman H Hasan, Afaf El-Ansary
BACKGROUND: Abnormal phospholipid metabolism is a major component of many neurodevelopmental disorders including autism. Oral administration of propionic acid (PPA) can produce behavioral abnormalities and biochemical features in rodents similar to those observed in autism and can thus be used as a model to understand impaired brain fatty acid metabolism in autism. METHODS: The present study was designed to understand alterations in phospholipid metabolism in the brain of a rodent model of autism and to explore omega-3 and vitamin B12 as remedies...
August 31, 2018: Lipids in Health and Disease
Ping Jin, Yongming Pan, Zhiyong Pan, Jianqin Xu, Min Lin, Zhichao Sun, Maosheng Xu, Minli Chen
Unfortunately, after publication of this article [1], it was noticed that the order of correspondence addresses was reversed. Maosheng Xu should be listed before Minli Chen. The correct order of correspondence can be seen in this correction article.
August 29, 2018: Lipids in Health and Disease
Xinxin Yan, Zhongshan Gou, Yuan Li, Yu Wang, Jingyan Zhu, Guidong Xu, Qian Zhang
BACKGROUND: FGF21 is a critical endogenous regulator in energy homeostasis and systemic glucose and lipid metabolism. Despite intensive study of the metabolic functions of FGF21, its important role in heart disease needs further exploration. Apoptosis induced by ox-LDL in vascular endothelial cells is an important step in the progress of atherosclerosis. METHODS: The effects of FGF21 treatment on apoptosis induced by ox-LDL were tested in HUVECs. The role of FGF21 in atherosclerosis was studied by evaluating its function in apolipoprotein E double knockout (apoE-/-) mice...
August 29, 2018: Lipids in Health and Disease
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