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Lipids in Health and Disease

Pooneh Angoorani, Majid Khademian, Hanieh-Sadat Ejtahed, Ramin Heshmat, Mohammad Esmaeil Motlagh, Mahya Vafaeenia, Gita Shafiee, Armita Mahdivi-Gorabi, Mostafa Qorbani, Roya Kelishadi
BACKGROUND: Non-high-density lipoprotein cholesterol (non-HDL-C) is considered as a valuable predictor for dyslipidemia and subclinical atherosclerosis which can be an appropriate index for identifying individuals with metabolic syndrome (MetS). OBJECTIVE: To evaluate the association between non-HDL-C MetS and determine the optimal cut-points of non-HDL-C fractions for identifying MetS in Iranian children and adolescents. METHODS: This nationwide study was conducted in the framework of the fifth survey of a national school-based surveillance program on children and adolescents aged 7-18 years...
November 14, 2018: Lipids in Health and Disease
Qian Han, Sze C Yeung, Mary S M Ip, Judith C W Mak
BACKGROUND: Lipid dysregulation is a classical risk factor for cardiovascular disease (CVD), yet scanty evidence existed regarding cardiac lipid metabolism that is directly related to heart damage. Recently, the relationship between dyslipidemia and pro-inflammatory insults has led to further understanding on the CVD-predisposing effects of dyslipidemia. The aims of the present study were to investigate whether high-fat high-cholesterol (HFHC) diet-induced hyperlipidemia would cause heart damage and to study the potential role of local cardiac lipid dysregulation in the occurrence of cellular injury...
November 14, 2018: Lipids in Health and Disease
Tian Tian Li, Tian Bi Tan, Hai Qing Hou, Xiao Yun Zhao
OBJECTIVE: To identify differences in the expression of peroxisome proliferator-activated receptor alpha (PPARα) target genes in human peripheral blood mononuclear cells (PBMCs) associated with non-alcoholic fatty liver disease (NAFLD) among Chinese individuals. METHODS: Thirty healthy subjects were selected as the control group (CN), and 43 patients newly diagnosed with NAFLD were subdivided into two groups, non-obese group (NF, n = 21) and obese group (OF, n = 22)...
November 14, 2018: Lipids in Health and Disease
Sara Missaglia, Daniela Tavian, Laura Moro, Corrado Angelini
BACKGROUND: Deficiency of electron transfer flavoprotein dehydrogenase (ETFDH) is associated with multiple acyl-CoA dehydrogenase deficiency (MADD). This disorder is an autosomal recessive lipid storage myopathy (LSM) that exhibits a wide range of clinical features, including myopathy, weakness and multisystem dysfunctions. Many patients with late onset of MADD improve when treated with riboflavin and are also referred to as RR-MADD (riboflavin-responsive multiple Acyl-CoA dehydrogenase disorder)...
November 13, 2018: Lipids in Health and Disease
Slimen Selmi, Kais Rtibi, Dhekra Grami, Hichem Sebai, Lamjed Marzouki
BACKGROUND: The current study was conducted to evaluate the protective effect of Lavandula stoechas essential oils (LSEO) against malathion (M) exposure-caused reprotoxicity in male mice as well as the possible mechanisms implicated in such protection. METHODS: Six-eight-week-old male mice weighting 25-30 g were used and divided into four groups: normal-control, LSEO (50 mg/kg, b.w.), malathion (200 mg/kg, b.w.) and malathion + LSEO treated mice. Malathion was emulsioned in corn oil and per orally administered for 30 days...
November 8, 2018: Lipids in Health and Disease
Yanmei Zeng, Meiping Guan, Chenzhong Li, Lingling Xu, Zhongji Zheng, Jimin Li, Yaoming Xue
BACKGROUND: Bitter melon (BM, Momordica charantia) has been accepted as an effective complementary treatment of metabolic disorders such as diabetes, hypertension, dyslipidemia and etc. However it is unclear whether BM can prevent the progression of atherosclerosis. To confirm the effects of BM on atherosclerosis and explore its underlying mechanisms, we design this study. METHODS: Twenty four male apolipoprotein E knock-out (ApoE-/-) mice aged 8 weeks were randomly divided into control group fed with high fat diet (HFD) only and BM group fed with HFD mixed with 1...
November 6, 2018: Lipids in Health and Disease
Di Sun, Bing-Yang Zhou, Sha Li, Ning-Ling Sun, Qi Hua, Shu-Lin Wu, Yun-Shan Cao, Yuan-Lin Guo, Na-Qiong Wu, Cheng-Gang Zhu, Ying Gao, Chuan-Jue Cui, Geng Liu, Jian-Jun Li
BACKGROUND: Although there have been many reports in the genetics of familial hypercholesterolemia (FH) worldwide, studies in regard of Chinese population are lacking. In this multi-center study, we aim to characterize the genetic spectrum of FH in Chinese population, and examine the genotype-phenotype correlations in detail. METHODS: A total of 285 unrelated index cases from China with clinical FH were consecutively recruited. Next-generation sequencing and bioinformatics tools were used for mutation detection of LDLR, APOB and PCSK9 genes and genetic analysis...
November 6, 2018: Lipids in Health and Disease
Xiaoli Liu, Mengge Li, Xinhui Wang, Zhibo Dang, Yuyong Jiang, Xianbo Wang, Zhiyun Yang
BACKGROUND: The liver plays an important role in the metabolism of lipid and lipoprotein. Dyslipidemia has been demonstrated to be related with several cancers, but the association between serum lipid and hepatocellular carcinoma (HCC) in the absence of cirrhosis remains unclear. METHODS: A total of 2528 patients with HCC at the Beijing Ditan Hospital between February 2008 and December 2017 were retrospectively included in the study. We identified 200 patients with HCC without cirrhosis by histopathology, imaging, endoscopic findings, and laboratory tests...
November 6, 2018: Lipids in Health and Disease
Bertrand Cariou, Gaëlle Challet-Bouju, Céline Bernard, Marie Marrec, Jean-Benoit Hardouin, Charlotte Authier, Kalyane Bach-Ngohou, Christophe Leux, Matthieu Pichelin, Marie Grall-Bronnec
BACKGROUND: Hypobetalipoproteinemia (HBL) is defined by plasma concentrations of LDL-cholesterol (LDL-C) lower than the fifth percentile for age and sex. Several psychiatric symptoms have been reported in association with HBL. The objective was to assess the prevalence of primary HBL in patients hospitalized in a psychiatric population and to better characterize the related psychiatric disorders. METHODS: HYPOPSY is a retrospective study including 839 adults hospitalized in the Psychiatry department of Nantes University Hospital during the year 2014, except patients with eating disorders...
November 6, 2018: Lipids in Health and Disease
Chao Cai, Zanlin Mai, Tuo Deng, Zhijian Zhao, Wei Zhu, Yaoan Wen, Xiaolu Duan, Wenqi Wu, Guohua Zeng
PURPOSES: To evaluate the influence of dyslipidemia on 24-h urine composition in adults who were non-stone formers (NF). METHODS: Samples for 24-h urine composition were analyzed from 584 NF adults without urolithiasis in a national six-city-based epidemiologic study. The samples were divided into groups based on total cholesterol (TC), triglycerides (TG), high-density lipoprotein (HDL), and low-density lipoprotein (LDL). The groups were compared based on demographic data and each component of 24-h urinalysis...
November 6, 2018: Lipids in Health and Disease
Mimi Tang, Ruili Dang, Shao Liu, Mengqi Zhang, Yi Zheng, Rui Yang, Tao Yin
BACKGROUND: The mechanisms underlying the association between immune activation and postpartum depression remained elusive. Although Ω-3 fatty acids possess anti-inflammatory properties, there is limited evidence directly linking the modulating effects of Ω-3 fatty acids on neuroimmune and neurochemistry to the antidepressant actions. METHODS: A between-groups design was used to assess the effects of reproductive status (virgin or parous) and Ω-3 fatty acids content (control and supplementary)...
November 3, 2018: Lipids in Health and Disease
Chen Wang, Lingying Kong, Yide Yang, Yumei Wei, Weiwei Zhu, Rina Su, Li Lin, Huixia Yang
BACKGROUND: Disturbances in maternal lipid metabolism have been shown to increase the risk of adverse pregnancy outcomes. However, there is no consensus as to what constitutes normal maternal lipid values during pregnancy. Thus, the aim of this study was to establish serum lipid reference ranges during early and middle pregnancy. METHODS: We conducted a retrospective survey in Beijing from 2013 to 2014. A total of 17,610 singleton pregnancies with lipid data from early and middle pregnancy were included...
October 31, 2018: Lipids in Health and Disease
Shima Aslian, Razieh Yazdanparast
BACKGROUND: Dracocephalum kotschyi, as a wild-growing flowering plant (from Lamiaceae family), is locally prescribed for its various health-promoting properties including hypolipidemic and hypoglycemic effects. To evaluate the scientific basis of the traditional use of Dracocephalum kotschyi extract (DKE), we aimed to disclose its mode of action with main focus on white adipose tissue of diabetic rats. METHODS: Streptozotocin-induced diabetic rats were exposed to different doses of DKE for 28 days followed by the determination of the sera biochemical factors...
October 30, 2018: Lipids in Health and Disease
Xiaona Wang, Li Sheng, Ping Ye, Ruihua Cao, Xu Yang, Wenkai Xiao, Yun Zhang, Yongyi Bai, Hongmei Wu
BACKGROUND: An association of hepcidin with cardiovascular (CV) disease and atherosclerosis has been reported in different patient groups. However, it has not been well described clinically the association between hepcidin and arterial stiffness. In this study,We analysed the possible mechanism of Hepcidin and arterial stiffness. METHODS: This article related measurements of plasma hepcidin and arterial stiffness (carotid-femoral pulse wave velocity [PWV]) in a community-based sample...
October 30, 2018: Lipids in Health and Disease
Erli Pei, Yang Liu, Weiqing Jiang, Songruo Lin, Lei Huang, Moubin Lin, Li Cai
BACKGROUND: A high-fat diet (HFD) is known to lead to obesity, and contributes to the progression of non-alcoholic fatty liver disease. The objective of this study was to evaluate the effects of sleeve gastrectomy (SG) on the progression of HFD-induced hepatic steatosis. METHODS: Fifteen 4-week-old, male Wistar rats were randomly assigned into three groups: NC, HFD + SHAM and HFD + SG. Their body weight, glucose-lipid metabolism, inflammation indices, hepatic steatosis and fibroblast growth factor 21 (FGF21) levels were measured...
October 24, 2018: Lipids in Health and Disease
Yizhi Pan, Tianyi Wang, Yanfang Li, Tianwang Guan, Yanxian Lai, Yan Shen, Abudurexiti Zeyaweiding, Tutiguli Maimaiti, Fang Li, Haiyan Zhao, Cheng Liu
BACKGROUND: Cardiovascular benefits by reversing environmental risks factors for essential hypertension (EH) and dyslipidemia could be weaken by high genetic risk. We investigated possible associations between ACE2 polymorphisms and dyslipidemia in patients with EH. METHODS: Four hundred and two hypertensive patients were enrolled in an EH group and 233 normotensive individuals were enrolled as control group from the Xinjiang region of China. Fourteen ACE2 polymorphisms were genotyped by Matrix-assisted laser desorption ionization time-of-flight mass spectrometry...
October 20, 2018: Lipids in Health and Disease
Ana Elisa M Martinelli, Raul C Maranhão, Priscila O Carvalho, Fatima R Freitas, Bruna M O Silva, Milena N C Curiati, Roberto Kalil Filho, Antonio Carlos Pereira-Barretto
BACKGROUND: Heart failure (HF) courses with chronic inflammatory process and alterations in lipid metabolism may aggravate the disease. The aim was to test whether the severity of HF, using brain natriuretic peptide (BNP) as a marker, is associated with alterations in functional aspects of HDL, such as lipid transfer, cholesterol ester transfer protein (CETP) and lecithin-cholesterol acyltransferase (LCAT) concentration. METHODS: Twenty-five HF patients in NYHA class I/II and 23 in class III/IV were enrolled...
October 20, 2018: Lipids in Health and Disease
Shouyuan Ma, Shuxia Wang, Man Li, Yan Zhang, Ping Zhu
Cardiovascular disease (CVD) is a leading cause of death worldwide. Atherosclerosis is believed to be the major cause of CVD, characterized by atherosclerotic lesion formation and plaque disruption. Although remarkable advances in understanding the mechanisms of atherosclerosis have been made, the application of these theories is still limited in the prevention and treatment of atherosclerosis. Therefore, novel and effective strategies to treat high-risk patients with atherosclerosis require further development...
October 17, 2018: Lipids in Health and Disease
Cong Ai, Shanshan Zhang, Qiao He, Jingpu Shi
BACKGROUND: Although there were many studies reporting the combination therapy of Ezetimibe and Atorvastatin's efficacy and Atorvastatin monotherapy's, the conclusions were controversial. Therefore, a systematic review and meta analysis of combination therapy and monotherapy were conducted. METHODS: PubMed, Cochrane Library and Embase were searched for studies of the combination therapy of Ezetimibe and Atorvastatin and Atorvastatin monotherapy published up to October 20, 2017...
October 17, 2018: Lipids in Health and Disease
Miso Kang, Hye Jin Yoo, Minjoo Kim, Minkyung Kim, Jong Ho Lee
BACKGROUND: Using metabolomics technique to analyze the response to a dietary intervention generates valuable information concerning the effects of the prescribed diet on metabolic regulation. To determine whether low calorie diet (LCD)-induced weight reduction causes changes in plasma metabolites and metabolic characteristics. METHODS: Overweight subjects consumed a LCD (n = 47) or a weight maintenance diet (control, n = 50) in a randomized, controlled design study with a 12-week clinical intervention period...
October 15, 2018: Lipids in Health and Disease
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