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Lipids in Health and Disease

Lijuan Ma, Hui Xiao, Juan Wen, Zhan Liu, Yi He, Fang Yuan
BACKGROUND: This study explored the possible mechanism of flavones from Vitis vinifera L. (VTF) on neurotransmitters, synaptic transmission and related learning and memory in rats with Alzheimer disease (AD). METHODS: The researchers injected amyloid-β(25-35) into the hippocampus to establish AD model rats. The Sprague-Dawley (SD) rats were divided into a control group, a donepezil group, an AD model group, a VTF low-dose group, a VTF medium-dose group and a VTF high-dose group...
July 4, 2018: Lipids in Health and Disease
Lijun Wang, Yang Wang, Hongwei Wang, Xue Zhou, Xianjing Wei, Zezhou Xie, Zhipeng Zhang, Keke Wang, Jianjun Mu
BACKGROUND: Intestinal microflora has been shown to play essential roles in the clinical therapies of metabolic diseases. The present study is aiming to investigate the potential roles and mechanisms of how intestinal microflora mediates lipid-reduction efficacy of Rosuvastatin. METHODS: To investigate the correlation between the intestinal microflora and efficacy of Rosuvastatin, we analyzed the diversity of intestinal microflora using PCR-DGGE analysis and 16S rDNA sequencing approaches...
June 30, 2018: Lipids in Health and Disease
Yun Luo, Zheng Li, Jiahui Zhang, Jingwei Li, Zhengjuan Lu
BACKGROUND: Diabetes mellitus (DM) was prone to happening in posterior circulation infarction (POCI) and DM also has the impact on the lipids, our study was to investigate the correlation between lipid compositions and POCI. METHODS: Data was collected from the patients with acute ischemic stroke (AIS) hospitalization in Affiliated Drum Tower Hospital of Nanjing University Medical School from October 2008 to May 2012. Lipids and other risk factors in the different populations were investigated in relation to occurrence of POCI based on the infarction location...
June 26, 2018: Lipids in Health and Disease
Dietmar Enko, Wolfgang Brandmayr, Gabriele Halwachs-Baumann, Wolfgang J Schnedl, Andreas Meinitzer, Gernot Kriegshäuser
BACKGROUND: So far, studies on possible association of plasma lipid levels and depressive disorder are contradictory. This prospective work aimed at assessing a plasma lipid profile in individuals with major depression and healthy controls. METHODS: In total, 94 patients with major depression and 152 healthy controls were included in this prospective study. After an overnight fasting state of 12 h they underwent blood drawing for triglyzerides (TG), total cholesterol, low-density lipoprotein (LDL)- and high-density lipoprotein (HDL)-cholesterol measurements...
June 26, 2018: Lipids in Health and Disease
Yuanxing Hang, Xian Qin, Tianli Ren, Jianing Cao
BACKGROUND: Patients with rheumatoid arthritis (RA) have an increased risk of coronary artery disease (CAD) above the baseline. Baicalin possesses beneficial effects against both RA and CAD, but little is know on its clincial efficacy among patients manifesting both CAD and RA. METHODS: Three hundred seventy four patients with CAD and RA were randomized to receive either 500 mg baicalin or placebo orally everyday for 12 weeks. Lipid profile, cardiotrophin-1 (CT-1), high sensitivity C-reactive protein (hs-CRP), European League Against Rheumatism (EULAR) response were analyzed at the end of study period...
June 23, 2018: Lipids in Health and Disease
Tomonori Nakanishi, Ibuki Motoba, Mayuko Anraku, Ryoji Suzuki, Yuto Yamaguchi, Laurie Erickson, Nozomu Eto, Kazuhiro Sugamoto, Yohichi Matsushita, Satoshi Kawahara
BACKGROUND: Among the eight stereoisomers of phytanic acid (PA), the 3RS, 7R, 11R-isomer is naturally occurring and is present in foods and the human body. PA is considered to have possible health benefits in the immune system. However, it remains undetermined whether these effects are elicited by the 3RS, 7R, 11R-PA isomer, because previous studies used a commercially available PA whose isomer configuration is unknown. In this study, we synthesized a preparation of 3RS, 7R, 11R-PA, and investigated its in vitro immunomodulatory effects, especially the T-cell production of interferon (IFN)-γ, which is associated with various autoimmune diseases...
June 23, 2018: Lipids in Health and Disease
Jun-Kai Yan, Wei-Hui Yan, Wei Cai
BACKGROUND: Excessive cell death of enterocytes has been demonstrated to be partially associated with the intravenously-administrated lipid emulsions (LEs) during parenteral nutrition (PN) support. However, as a new generation of LE, the effect of fish oil-derived lipid emulsion (FOLE) on the death of enterocytes remains elusive. METHODS: Intestinal epithelial cells (IEC-6 cell line) were treated with FOLE (0.25-1%) for 24 h. Cell survival was measured by CCK-8 assay, and morphological changes were monitored by time-lapse live cell imaging...
June 23, 2018: Lipids in Health and Disease
J M Gómez-Martin, J A Balsa, E Aracil, M Cuadrado-Ayuso, M Rosillo, G De la Peña, M A Lasunción, H F Escobar-Morreale, J I Botella-Carretero
BACKGROUND: The beneficial effects in lipid profiles after obesity surgery might be associated with the decrease in cardiovascular risk. However, direct comparison between different surgical techniques has not been extensively performed. METHODS: In the present study we compare 20 obese women submitted to laparoscopic Roux en Y gastric bypass (RYGB) with 20 women submitted to sleeve gastrectomy (SG). Twenty control women matched for age and baseline cardiovascular risk were also included...
June 20, 2018: Lipids in Health and Disease
Xiaoyao Li, Qi Yang, Xiaolei Shi, Weiwei Chen, Na Pu, Weiqin Li, Jieshou Li
BACKGROUND: Variants in the lipoprotein lipase (LPL), apolipoprotein C-II (APOC2), apolipoprotein A-V (APOA5), GPIHBP1 and LMF1 genes may cause severe hypertriglyceridemia (HTG), which is now the second-leading aetiology of acute pancreatitis in China. METHODS: The patient and his family were assessed for gene variants by Sanger sequencing of exons and exon-intron junctions of the LPL, GPIHBP1, APOA5, APOC2, and LMF1 genes. Post-heparin blood was collected for LPL mass and activity detection...
June 19, 2018: Lipids in Health and Disease
YuJing Wu, ZhiJuan Fan, YaQiong Tian, Shuang Liu, ShuYe Liu
BACKGROUND: Trails aimed at raising high density lipoprotein(HDL) cholesterol concentration failed to make better cardiovascular outcomes. HDL particles may be better biomarkers reflecting properties of HDL. This meta-analysis was conducted to evaluate the relation between blood HDL particles level and cardiovascular events. METHODS: PubMed and other databases were searched for eligible studies and NewCastle-Ottawa Quality Assessment Scale(NOS) was used to assess the quality of included studies...
June 19, 2018: Lipids in Health and Disease
Ling-Bing Meng, Ruomei Qi, Lei Xu, Yuhui Chen, Zemou Yu, Peng Guo, Tao Gong
BACKGROUND: The mortality of atherosclerotic cerebrovascular disease is on the rise, and changes in intimal and media thickness are a leading cause of cerebral ischemia-related death. Levels of low density lipoprotein cholesterol (LDLC), total cholesterol (TC), and chronic stress (CS) are all recognized risk factors for atherosclerosis (AS). However, the leading independent risk factor is indistinct. This study explored the effects of chronic stress, LDLC, and TC on AS and intimal and media thickness, preliminarily explored the main risk factor of AS, and analyzed the related histocyte mechanisms for macrophages and endothelial cells...
June 19, 2018: Lipids in Health and Disease
Huan-Gao Zhu, Zhao-Shun Jiang, Pi-Yun Gong, Dong-Mei Zhang, Zhi-Wei Zou, Qian-Zhang, Hui-Mei Ma, Zhen-Gang Guo, Jun-Yu Zhao, Jian-Jun Dong, Lin-Liao
BACKGROUND: A low-protein diet (LPD) is believed to be beneficial in slowing the progression of kidney disease. It is reported that low protein diet can improve protein, sugar and lipid metabolism, and reduce the symptoms and complications of renal insufficiency. However, there has been controversial regarding the effects of protein restriction on diabetic nephropathy (DN). OBJECTIVE: To investigate the efficacy of LPD on renal function in patients with type 1 or 2 DN by meta-analysis of randomized controlled trials (RCTs)...
June 19, 2018: Lipids in Health and Disease
Melissa Johnson, Ralphenia D Pace, Wendell H McElhenney
BACKGROUND: In addition to the actual composition of the diet (i.e. nutrient composition, food groups), the omega-6/omega-3 fatty acid ratio has been demonstrated to influence the tissue fatty acid profile and subsequently the risk for cardiovascular and other diseases. Likewise, the consumption of green leafy vegetables (GLVs) may favorably reduce the risks associated with disease. Although an ~ 3:1 omega-6/omega-3 fatty acid ratio (ω-6/ω-3 FAR) is recommended, the typical American diet has an ~ 25:1 ω-6/ω-3 FAR...
June 15, 2018: Lipids in Health and Disease
Guoqi Su, Xuanwu Zhou, Yu Wang, Daiwen Chen, Guang Chen, Yan Li, Jun He
BACKGROUND: The aim of this study was to determine the effects of plant essential oil supplementation on growth performance, immune function and antioxidant activities in weaned pigs. METHODS: In the study, 24 weaned pigs were used to explore the effects of plant essential oil (PEO) on growth performance, immune properties and antioxidant activities. Pigs were fed with a basal diet (CON) or basal diet containing different concentrations of PEO (PEO50: 50 ppm; PEO100: 100 ppm; PEO200: 200 ppm)...
June 15, 2018: Lipids in Health and Disease
Mohsen Hanana, Hajer Mezghenni, Rayda Ben Ayed, Ali Ben Dhiab, Slim Jarradi, Bassem Jamoussi, Lamia Hamrouni
BACKGROUND: Argan oil is traditionally produced by cold pressing in South-western Morocco where rural population uses it as edible oil as well as for its therapeutic properties which give them in counterpart valuable income. Given the economical interest of this oil, several attempts of fraudulency have been registered in the world global market leading to loss of authenticity. Our purpose is to launch a program of Tunisian Argan oil valorization since trees from this species have been introduced sixty years ago in Tunisia...
June 15, 2018: Lipids in Health and Disease
Manabu Mukai, Kentaro Uchida, Shotaro Takano, Dai Iwase, Jun Aikawa, Gen Inoue, Masayuki Miyagi, Masashi Takaso
BACKGROUND: While epidemiological studies have reported a potential role for hypercholesterolemia (HCE) in osteoarthritis (OA), the association between HCE and OA has yet to be clarified. Adipose tissue is a primary locus for cholesterol metabolism and the presence of HCE reportedly causes adipose dysfunction. The knee joint contains adipose tissue in the form of the infrapatellar fat pad (IPFP), which has been shown to contribute to the pathophysiology of OA in the knee via the secretion of inflammatory mediators...
June 13, 2018: Lipids in Health and Disease
Madiha Maboos, Rabia Ismail Yousuf, Muhammad Harris Shoaib, Iqbal Nasiri, Tazeen Hussain, Hafiza Fouzia Ahmed, Wajiha Iffat
BACKGROUND: The study was to develop an extended release (ER) encapsulated and compacted pellets of Atenolol using hydrophobic (wax based and polymeric based) and high viscosity grade hydrophilic matrix formers to control the release of this highly water soluble drug by extrusion/spheronization (ES). Atenolol is used for cardiovascular diseases and available as an immediate release (IR) tablet dosage form. The lipids, Carnauba wax (CW), Glyceryl monostearate (GMS) and cellulose based i...
June 9, 2018: Lipids in Health and Disease
Noriaki Kawanishi, Yuki Kato, Kyosuke Yokozeki, Shuji Sawada, Ryota Sakurai, Yoshinori Fujiwara, Shoji Shinkai, Nobuhito Goda, Katsuhiko Suzuki
BACKGROUND: Aging is known to be associated with increased risk of lipid disorders related to the development of type 2 diabetes. Recent evidence revealed that change of lipid molecule species in blood is associated with the risk of type 2 diabetes. However, changes in lipid molecular species induced by aging are still unknown. We assessed the effects of age on the serum levels of lipid molecular species as determined by lipidomics analysis. METHODS: Serum samples were collected from ten elderly men (71...
June 6, 2018: Lipids in Health and Disease
Sameer Al-Ghamdi, Mamdouh M Shubair, Abdulrahman Aldiab, Jamaan M Al-Zahrani, Khaled K Aldossari, Mowafa Househ, Shanila Nooruddin, Hira Abdul Razzak, Ashraf El-Metwally
BACKGROUND: Obesity and overweight are accompanied with several different chronic diseases. Overweight and obesity can be measured by using body mass index (BMI) and is also used widely as an index of relative adiposity among any population. The aim of the study is to evaluate the prevalence of overweight and obesity among general population in Al-Kharj, Saudi Arabia. METHODS: Cross-sectional analysis was undertaken from a representative sample (N = 1019) of the Al Kharj population...
June 5, 2018: Lipids in Health and Disease
Ruixia Zeng, Yan Fang, Yibo Zhang, Shuling Bai
BACKGROUND: Obesity is closely related to the abnormal differentiation of adipocytes, which are subjected to high plasma levels of free fatty acids (FFAs). As the most abundant FFA in the bloodstream, oleic acid (OA) has the ability to induce adipogenic differentiation in human adipose-derived stromal cells (hADSCs). Recently, p62, an autophagy mediator, has been shown to play a role in obesity and adipose tissue metabolism. Therefore, the aim of this study was to investigate the roles of autophagy and mitochondrial function at different stages of OA (in combination with insulin and dexamethasone)-induced adipogenesis in hADSCs...
June 4, 2018: Lipids in Health and Disease
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