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Cardiovascular Diabetology

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https://www.readbyqxmd.com/read/29788955/effect-of-canagliflozin-on-left-ventricular-diastolic-function-in-patients-with-type-2-diabetes
#1
Daisuke Matsutani, Masaya Sakamoto, Yosuke Kayama, Norihiko Takeda, Ryuzo Horiuchi, Kazunori Utsunomiya
BACKGROUND: Type 2 diabetes mellitus (T2DM) greatly increases the risks of cardiovascular disease and heart failure. In particular, left ventricular diastolic dysfunction that develops from the early stages of T2DM is an important factor in the onset and exacerbation of heart failure. The effect of sodium-glucose cotransporter 2 inhibitors on left ventricular diastolic function has not been elucidated. We have performed the first prospective study on the effects of canagliflozin on left ventricular diastolic function in T2DM...
May 22, 2018: Cardiovascular Diabetology
https://www.readbyqxmd.com/read/29776406/the-effect-of-dpp-4-inhibition-to-improve-functional-outcome-after-stroke-is-mediated-by-the-sdf-1%C3%AE-cxcr4-pathway
#2
Fausto Chiazza, Harald Tammen, Hiranya Pintana, Grazyna Lietzau, Massimo Collino, Thomas Nyström, Thomas Klein, Vladimer Darsalia, Cesare Patrone
BACKGROUND: Dipeptidyl peptidase-4 (DPP-4) inhibitors (gliptins) are approved drugs for the treatment of hyperglycemia in patients with type 2 diabetes. These effects are mainly mediated by inhibiting endogenous glucagon-like peptide-1 (GLP-1) cleavage. Interestingly, gliptins can also improve stroke outcome in rodents independently from GLP1. However, the underlying mechanisms are unknown. Stromal cell-derived factor-1α (SDF-1α) is a DPP-4 substrate and CXCR4 agonist promoting beneficial effects in injured brains...
May 19, 2018: Cardiovascular Diabetology
https://www.readbyqxmd.com/read/29773082/no-detectable-differential-microrna-expression-between-non-atherosclerotic-arteries-of-type-2-diabetic-patients-treated-or-untreated-with-metformin-and-non-diabetic-patients
#3
Lasse Bach Steffensen, Søren Feddersen, Simone Rørdam Preil, Lars Melholt Rasmussen
BACKGROUND: Type 2 diabetes mellitus (T2DM) is an independent risk factor of cardiovascular disease (CVD), however, the underlying mechanisms are largely unknown. Using non-atherosclerotic internal thoracic arteries (ITAs) obtained from coronary artery bypass grafting, we previously identified a distinct elevation in the level of proteins comprising the arterial basement membrane in T2DM patients not treated with metformin. Altered transcription of genes encoding these proteins has not been observed, indicating alternative mechanisms of dysregulation...
May 17, 2018: Cardiovascular Diabetology
https://www.readbyqxmd.com/read/29773079/effects-of-linagliptin-on-endothelial-function-and-postprandial-lipids-in-coronary-artery-disease-patients-with-early-diabetes-a-randomized-placebo-controlled-double-blind-trial
#4
Norbert J Tripolt, Felix Aberer, Regina Riedl, Jasmin Url, Gudrun Dimsity, Andreas Meinitzer, Tatjana Stojakovic, Faisal Aziz, Ronald Hödl, Gabriele Brachtl, Dirk Strunk, Marianne Brodmann, Franz Hafner, Harald Sourij
BACKGROUND: Early glucose lowering intervention in subjects with type 2 diabetes mellitus was demonstrated to be beneficial in terms of micro- and macrovascular risk reduction. However, most of currently ongoing cardiovascular outcome trials are performed in subjects with manifest atherosclerosis and long-standing diabetes. Therefore, the aim of this study is to investigate the effects of the dipeptidylpeptidase-4 inhibitor linagliptin in subjects with coronary artery disease (CAD) but early type 2 diabetes mellitus (T2DM) on a set of cardiovascular surrogate measurements...
May 17, 2018: Cardiovascular Diabetology
https://www.readbyqxmd.com/read/29764436/prevalence-and-incidence-of-complications-at-diagnosis-of-t2dm-and-during-follow-up-by-bmi-and-ethnicity-a-matched-case-control-analysis
#5
Ebenezer S Owusu Adjah, Srikanth Bellary, Wasim Hanif, Kiran Patel, Kamlesh Khunti, Sanjoy K Paul
AIMS: To estimate the risk of developing long-term major cardiovascular and renal complications in relation to levels of body mass index (BMI) in a population of White European (WE), African-Caribbean (AC), and South Asian (SA) patients with type 2 diabetes mellitus (T2DM). MATERIALS AND METHODS: Patients with new diagnosis of T2DM, aged ≥ 18 years from January 2000 (n = 69,436) and their age-sex-ethnicity matched non-diabetic controls (n = 272,190) were identified from UK primary care database...
May 15, 2018: Cardiovascular Diabetology
https://www.readbyqxmd.com/read/29759068/childhood-retinol-binding-protein-4-rbp4-levels-predicting-the-10-year-risk-of-insulin-resistance-and-metabolic-syndrome-the-bcams-study
#6
Ge Li, Issy C Esangbedo, Lu Xu, Junling Fu, Lujiao Li, Dan Feng, Lanwen Han, Xinhua Xiao, Mingyao Li, Jie Mi, Ming Li, Shan Gao, Steven M Willi
BACKGROUND: Elevated retinol-binding protein 4 (RBP4) levels may contribute to the development of metabolic abnormalities, but prospective studies evaluating the association between childhood RBP4 levels and metabolic syndrome (MS) in adulthood are lacking. We investigated whether RBP4 levels during childhood predict cardiometabolic risk at 10-year follow-up. METHODS: The relationships between RBP4 levels, the established adipokines (leptin and adiponectin) and the components of MS were examined in 3445 school-aged children recruited in 2004 for the Beijing Child and Adolescent Metabolic Syndrome study...
May 14, 2018: Cardiovascular Diabetology
https://www.readbyqxmd.com/read/29753320/adverse-effects-of-hif1a-mutation-and-maternal-diabetes-on-the-offspring-heart
#7
Radka Cerychova, Romana Bohuslavova, Frantisek Papousek, David Sedmera, Pavel Abaffy, Vladimir Benes, Frantisek Kolar, Gabriela Pavlinkova
BACKGROUND: Epidemiological studies show that maternal diabetes predisposes offspring to cardiovascular and metabolic disorders. However, the precise mechanisms for the underlying penetrance and disease predisposition remain poorly understood. We examined whether hypoxia-inducible factor 1 alpha, in combination with exposure to a diabetic intrauterine environment, influences the function and molecular structure of the adult offspring heart. METHODS AND RESULTS: In a mouse model, we demonstrated that haploinsufficient (Hif1a+/- ) offspring from a diabetic pregnancy developed left ventricle dysfunction at 12 weeks of age, as manifested by decreased fractional shortening and structural remodeling of the myocardium...
May 12, 2018: Cardiovascular Diabetology
https://www.readbyqxmd.com/read/29751802/associations-of-coronary-artery-calcified-plaque-density-with-mortality-in-type-2-diabetes-the-diabetes-heart-study
#8
Laura M Raffield, Amanda J Cox, Michael H Criqui, Fang-Chi Hsu, James G Terry, Jianzhao Xu, Barry I Freedman, J Jeffrey Carr, Donald W Bowden
BACKGROUND: Coronary artery calcified plaque (CAC) is strongly predictive of cardiovascular disease (CVD) events and mortality, both in general populations and individuals with type 2 diabetes at high risk for CVD. CAC is typically reported as an Agatston score, which is weighted for increased plaque density. However, the role of CAC density in CVD risk prediction, independently and with CAC volume, remains unclear. METHODS: We examined the role of CAC density in individuals with type 2 diabetes from the family-based Diabetes Heart Study and the African American-Diabetes Heart Study...
May 11, 2018: Cardiovascular Diabetology
https://www.readbyqxmd.com/read/29728117/diabetic-retinopathy-is-associated-with-the-presence-and-burden-of-subclinical-carotid-atherosclerosis-in-type-1-diabetes
#9
Marc Carbonell, Esmeralda Castelblanco, Xavier Valldeperas, Àngels Betriu, Alícia Traveset, Minerva Granado-Casas, Marta Hernández, Federico Vázquez, Mariona Martín, Esther Rubinat, Albert Lecube, Josep Franch-Nadal, Elvira Fernández, Manel Puig-Domingo, Angelo Avogaro, Núria Alonso, Dídac Mauricio
BACKGROUND: Cardiovascular (CV) disease due to atherosclerosis is a major cause of morbidity and mortality in adult patients with diabetes, either type 1 or type 2 diabetes. The aim of the study was to assess the association of the frequency and the burden of subclinical carotid atherosclerotic disease in patients with type 1 diabetes according to the presence and severity of diabetic retinopathy (DR). METHODS: A cross-sectional study was conducted in 340 patients with type 1 diabetes (41...
May 4, 2018: Cardiovascular Diabetology
https://www.readbyqxmd.com/read/29724198/the-synergistic-effects-of-saxagliptin-and-metformin-on-cd34-endothelial-progenitor-cells-in-early-type-2-diabetes-patients-a-randomized-clinical-trial
#10
Fiona J Dore, Cleyton C Domingues, Neeki Ahmadi, Nabanita Kundu, Yana Kropotova, Sara Houston, Carol Rouphael, Aytan Mammadova, Linda Witkin, Anamil Khiyami, Richard L Amdur, Sabyasachi Sen
AIMS: Type 2 diabetes is associated with endothelial dysfunction leading to cardiovascular disease. CD34+ endothelial Progenitor Cells (EPCs) are responsible for endothelial repair and neo-angiogenesis and can be used as a cardiovascular disease risk biomarker. This study investigated whether the addition of saxagliptin, a DPP-IV inhibitor, to metformin, may reduce cardiovascular disease risk in addition to improving glycemic control in Type 2 diabetes patients. METHODS: In 12 week, double-blind, randomized placebo-controlled trial, 42 subjects already taking metformin 1-2 grams/day were randomized to placebo or saxagliptin 5 mg...
May 3, 2018: Cardiovascular Diabetology
https://www.readbyqxmd.com/read/29720185/exercise-training-and-endothelial-function-in-patients-with-type-2-diabetes-a-meta-analysis
#11
Shanhu Qiu, Xue Cai, Han Yin, Zilin Sun, Martina Zügel, Jürgen Michael Steinacker, Uwe Schumann
BACKGROUND AND AIMS: Exercise training is considered a cornerstone in the management of type 2 diabetes, which is associated with impaired endothelial function. However, the association of exercise training with endothelial function in type 2 diabetes patients has not been fully understood. This meta-analysis aimed to investigate their associations with focus on exercise types. METHODS: Databases were searched up to January 2018 for studies evaluating the influences of exercise training with durations ≥ 8 weeks on endothelial function assessed by flow-mediated dilation (FMD) among type 2 diabetes patients or between type 2 diabetics and non-diabetics...
May 2, 2018: Cardiovascular Diabetology
https://www.readbyqxmd.com/read/29712560/cardiovascular-disease-risk-factor-responses-to-a-type-2-diabetes-care-model-including-nutritional-ketosis-induced-by-sustained-carbohydrate-restriction-at-1-year-an-open-label-non-randomized-controlled-study
#12
Nasir H Bhanpuri, Sarah J Hallberg, Paul T Williams, Amy L McKenzie, Kevin D Ballard, Wayne W Campbell, James P McCarter, Stephen D Phinney, Jeff S Volek
BACKGROUND: Cardiovascular disease (CVD) is a leading cause of death among adults with type 2 diabetes mellitus (T2D). We recently reported that glycemic control in patients with T2D can be significantly improved through a continuous care intervention (CCI) including nutritional ketosis. The purpose of this study was to examine CVD risk factors in this cohort. METHODS: We investigated CVD risk factors in patients with T2D who participated in a 1 year open label, non-randomized, controlled study...
May 1, 2018: Cardiovascular Diabetology
https://www.readbyqxmd.com/read/29712555/prognostic-value-of-the-stanniocalcin-2-papp-a-igfbp-4-axis-in-st-segment-elevation-myocardial-infarction
#13
Germán Cediel, Ferran Rueda, Claus Oxvig, Teresa Oliveras, Carlos Labata, Oriol de Diego, Marc Ferrer, M Cruz Aranda-Nevado, Judith Serra-Gregori, Julio Núñez, Cosme García, Antoni Bayes-Genis
OBJECTIVE: The aim of the present study was to evaluate the prognostic value of the Stanniocalcin-2/PAPP-A/IGFBP-4 axis in patients with ST-segment elevation myocardial infarction (STEMI). METHODS: Observational cohort study performed in 1085 consecutive STEMI patients treated with early reperfusion between February 2011 and August 2014. Stanniocalcin-2, PAPP-A, and IGFBP-4 were measured using state-of-the art immunoassays. The primary outcome was the composite endpoint of all-cause mortality and readmission due to heart failure (HF)...
April 30, 2018: Cardiovascular Diabetology
https://www.readbyqxmd.com/read/29703207/sglt2-inhibition-via-dapagliflozin-improves-generalized-vascular-dysfunction-and-alters-the-gut-microbiota-in-type-2-diabetic-mice
#14
Dustin M Lee, Micah L Battson, Dillon K Jarrell, Shuofei Hou, Kayl E Ecton, Tiffany L Weir, Christopher L Gentile
BACKGROUND: Type 2 diabetes (T2D) is associated with generalized vascular dysfunction characterized by increases in large artery stiffness, endothelial dysfunction, and vascular smooth muscle dysfunction. Sodium glucose cotransporter 2 inhibitors (SGLT2i) represent the most recently approved class of oral medications for the treatment of T2D, and have been shown to reduce cardiovascular and overall mortality. Although it is currently unclear how SGLT2i decrease cardiovascular risk, an improvement in vascular function is one potential mechanism...
April 27, 2018: Cardiovascular Diabetology
https://www.readbyqxmd.com/read/29695241/novel-risk-genes-identified-in-a-genome-wide-association-study-for-coronary-artery-disease-in-patients-with-type-1-diabetes
#15
Romain Charmet, Seamus Duffy, Sareh Keshavarzi, Beata Gyorgy, Michel Marre, Peter Rossing, Amy Jayne McKnight, Alexander P Maxwell, Tarun Veer Singh Ahluwalia, Andrew D Paterson, David-Alexandre Trégouët, Samy Hadjadj
BACKGROUND: Patients with type 1 diabetes are more at risk of coronary artery disease than the general population. Although evidence points to a genetic risk there have been no study investigating genetic risk factors of coronary artery disease specific to individuals with type 1 diabetes. To identify low frequency and common genetic variations associated with coronary artery disease in populations of individuals with type 1 diabetes. METHODS: A two-stage genome wide association study was conducted...
April 25, 2018: Cardiovascular Diabetology
https://www.readbyqxmd.com/read/29669564/prevalence-of-left-ventricular-systolic-dysfunction-and-heart-failure-with-reduced-ejection-fraction-in-men-and-women-with-type-2-diabetes-mellitus-a-systematic-review-and-meta-analysis
#16
Selma Bouthoorn, Aisha Gohar, Gideon Valstar, Hester M den Ruijter, J B Reitsma, Arno W Hoes, Frans H Rutten
BACKGROUND: Type 2 diabetes mellitus (T2D) is associated with the development of left ventricular systolic dysfunction (LVSD) and heart failure with reduced ejection fraction (HFrEF). T2D patients with LVSD are at higher risk of mortality and morbidity than patients without LVSD, while progression of LVSD can be delayed or halted by the use of proven therapies. As estimates of the prevalence are scarce and vary considerably, the aim of this study was to retrieve summary estimates of the prevalence of LVSD/HFrEF in T2D and to see if there were any sex differences...
April 18, 2018: Cardiovascular Diabetology
https://www.readbyqxmd.com/read/29669555/the-role-of-dipeptidylpeptidase-4-inhibitors-in-management-of-cardiovascular-disease-in-diabetes-focus-on-linagliptin
#17
REVIEW
Annayya R Aroor, Camila Manrique-Acevedo, Vincent G DeMarco
Multiple population based analyses have demonstrated a high incidence of cardiovascular disease (CVD) and cardiovascular (CV) mortality in subjects with T2DM that reduces life expectancy by as much as 15 years. Importantly, the CV system is particularly sensitive to the metabolic and immune derangements present in obese pre-diabetic and diabetic individuals; consequently, CV dysfunction is often the initial CV derangement to occur and promotes the progression to end organ/tissue damage in T2DM. Specifically, diabetic CVD can manifest as microvascular complications, such as nephropathy, retinopathy, and neuropathy, as well as, macrovascular impairments, including ischemic heart disease, peripheral vascular disease, and cerebrovascular disease...
April 18, 2018: Cardiovascular Diabetology
https://www.readbyqxmd.com/read/29669543/diabetes-cardiovascular-disease-and-the-microcirculation
#18
REVIEW
W David Strain, P M Paldánius
Cardiovascular disease (CVD) is the leading cause of mortality in people with type 2 diabetes mellitus (T2DM), yet a significant proportion of the disease burden cannot be accounted for by conventional cardiovascular risk factors. Hypertension occurs in majority of people with T2DM, which is substantially more frequent than would be anticipated based on general population samples. The impact of hypertension is considerably higher in people with diabetes than it is in the general population, suggesting either an increased sensitivity to its effect or a confounding underlying aetiopathogenic mechanism of hypertension associated with CVD within diabetes...
April 18, 2018: Cardiovascular Diabetology
https://www.readbyqxmd.com/read/29636104/antidiabetic-treatment-patterns-and-specialty-care-utilization-among-patients-with-type-2-diabetes-and-cardiovascular-disease
#19
Kevin M Pantalone, Anita D Misra-Hebert, Todd M Hobbs, Xinge Ji, Sheldon X Kong, Alex Milinovich, Wayne Weng, Janine Bauman, Rahul Ganguly, Bartolome Burguera, Michael W Kattan, Robert S Zimmerman
BACKGROUND: To evaluate real-world patient characteristics, medication use, and health care utilization patterns in patients with type 2 diabetes with established cardiovascular disease (CVD). METHODS: Cross-sectional analysis of patients with type 2 diabetes seen at Cleveland Clinic from 2005 to 2016, divided into two cohorts: with-CVD and without-CVD. Patient demographics and antidiabetic medications were recorded in December 2016; department encounters included all visits from 1/1/2016 to 12/31/2016...
April 10, 2018: Cardiovascular Diabetology
https://www.readbyqxmd.com/read/29636047/liraglutide-suppresses-non-esterified-free-fatty-acids-and-soluble-vascular-cell-adhesion-molecule-1-compared-with-metformin-in-patients-with-recent-onset-type-2-diabetes
#20
Xiao-Min Chen, Wen-Qiang Zhang, Yuan Tian, Li-Fen Wang, Chan-Chan Chen, Chuan-Mei Qiu
BACKGROUND: It has been suggested that liraglutide could have an impact on glucose and lipid metabolism disorder and adhesion molecule activation, which may play important roles in the vascular damage of diabetes. In this study, we examined the effects of liraglutide versus metformin on non-esterified free fatty acids, beta-cell insulin secretion, and adhesion molecule levels in patients with recent-onset type 2 diabetes mellitus. METHODS: In this study, 60 patients newly diagnosed with type 2 diabetes mellitus (mean age 33...
April 10, 2018: Cardiovascular Diabetology
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