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Cardiovascular Diabetology

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https://www.readbyqxmd.com/read/27912784/liraglutide-improves-metabolic-parameters-and-carotid-intima-media-thickness-in-diabetic-patients-with-the-metabolic-syndrome-an-18-month-prospective-study
#1
Manfredi Rizzo, Ali A Rizvi, Angelo Maria Patti, Dragana Nikolic, Rosaria Vincenza Giglio, Giuseppa Castellino, Giovanni Li Volti, Massimiliano Caprio, Giuseppe Montalto, Vincenzo Provenzano, Stefano Genovese, Antonio Ceriello
BACKGROUND: Liraglutide, a GLP-1 analogue, exerts several beneficial non-glycemic effects in patients with type-2 diabetes (T2DM), such as those on body weight, blood pressure, plasma lipids and inflammation markers. However, the effects of liraglutide on cardiovascular (CV) risk markers in subjects with the metabolic syndrome (MetS) are still largely unknown. We herein explored its effects on various cardio-metabolic risk markers of the MetS in subjects with T2DM. METHODS: We performed an 18-month prospective, real-world study...
December 3, 2016: Cardiovascular Diabetology
https://www.readbyqxmd.com/read/27905927/characteristics-and-outcomes-of-diabetic-patients-with-an-implantable-cardioverter-defibrillator-in-a-real-world-setting-results-from-the-israeli-icd-registry
#2
Hillel Steiner, Michael Geist, Ilan Goldenberg, Mahmoud Suleiman, Michael Glikson, Alexander Tenenbaum, Moshe Swissa, Enrique Z Fisman, Gregory Golovchiner, Boris Strasberg, Alon Barsheshet
AIMS: There are limited data regarding the effect of diabetes mellitus (DM) on the risks of both appropriate and inappropriate implantable cardioverter defibrillator (ICD) therapy. The present study was designed to compare the outcome of appropriate and inappropriate ICD therapy in patients with or without DM. METHODS AND RESULTS: The risk of a first appropriate ICD therapy for ventricular tachyarrhythmias (including anti tachycardia pacing and shock) was compared between 764 DM and 1346 non-DM patients enrolled in the national Israeli ICD registry...
December 1, 2016: Cardiovascular Diabetology
https://www.readbyqxmd.com/read/27905925/expression-of-insulin-receptor-ir-a-and-b-isoforms-igf-ir-and-ir-igf-ir-hybrid-receptors-in-vascular-smooth-muscle-cells-and-their-role-in-cell-migration-in-atherosclerosis
#3
N Beneit, C E Fernández-García, J L Martín-Ventura, L Perdomo, Ó Escribano, J B Michel, G García-Gómez, S Fernández, S Díaz-Castroverde, J Egido, A Gómez-Hernández, M Benito
BACKGROUND: Abnormal proliferation and migration of vascular smooth muscle cells (VSMCs) is a major contributor to the development of atherosclerotic process. In a previous work, we demonstrated that the insulin receptor isoform A (IRA) and its association with the insulin-like growth factor-I receptor (IGF-IR) confer a proliferative advantage to VSMCs. However, the role of IR and IGF-IR in VSMC migration remains poorly understood. METHODS: Wound healing assays were performed in VSMCs bearing IR (IRLoxP(+/+) VSMCs), or not (IR(-/-) VSMCs), expressing IRA (IRA VSMCs) or expressing IRB (IRB VSMCs)...
December 1, 2016: Cardiovascular Diabetology
https://www.readbyqxmd.com/read/27899146/impact-of-visceral-fat-on-gene-expression-profile-in-peripheral-blood-cells-in-obese-japanese-subjects
#4
Yoshinari Obata, Norikazu Maeda, Yuya Yamada, Koji Yamamoto, Seiji Nakamura, Masaya Yamaoka, Yoshimitsu Tanaka, Shigeki Masuda, Hirofumi Nagao, Shiro Fukuda, Yuya Fujishima, Shunbun Kita, Hitoshi Nishizawa, Tohru Funahashi, Ken-Ichi Matsubara, Yuji Matsuzawa, Iichiro Shimomura
BACKGROUND: Visceral fat plays a central role in the development of metabolic syndrome and atherosclerotic cardiovascular diseases. The association of visceral fat accumulation with cardio-metabolic diseases has been reported, but the impact of visceral fat on the gene expression profile in peripheral blood cells remains to be determined. The aim of this study was to determine the effects of visceral fat area (VFA) and subcutaneous fat area (SFA) on the gene expression profile in peripheral blood cells of obese subjects...
November 29, 2016: Cardiovascular Diabetology
https://www.readbyqxmd.com/read/27881170/relationship-of-cardiometabolic-parameters-in-non-smokers-current-smokers-and-quitters-in-diabetes-a-systematic-review-and-meta-analysis
#5
REVIEW
Debasish Kar, Clare Gillies, Francesco Zaccardi, David Webb, Samuel Seidu, Solomon Tesfaye, Melanie Davies, Kamlesh Khunti
BACKGROUND: Smoking is associated with increased macrovascular and microvascular complications in people with diabetes. In addition to other concomitant vascular perturbations, it also seems to influence the cardiometabolic parameters, which may partly explain the accelerated rate of vascular complications in smokers with diabetes. While smoking cessation is advocated as a universal component of the management of diabetes, there is some anecdotal evidence that HbA1c could increase following smoking cessation...
November 24, 2016: Cardiovascular Diabetology
https://www.readbyqxmd.com/read/27835975/empagliflozin-lessened-cardiac-injury-and-reduced-visceral-adipocyte-hypertrophy-in-prediabetic-rats-with-metabolic-syndrome
#6
Hiroaki Kusaka, Nobutaka Koibuchi, Yu Hasegawa, Hisao Ogawa, Shokei Kim-Mitsuyama
BACKGROUND: The potential benefit of SGLT2 inhibitors in metabolic syndrome is with prediabetic stage unclear. This work was undertaken to investigate the non-glycemic effect of empagliflozin on metabolic syndrome rats with prediabetes. METHODS: SHR/NDmcr-cp(+/+) rats (SHRcp), a model of metabolic syndrome with prediabetes, were given empagliflozin for 10 weeks to examine the effects on urinary sodium and water balance, visceral and subcutaneous adipocyte, and cardiac injury...
November 11, 2016: Cardiovascular Diabetology
https://www.readbyqxmd.com/read/27832814/obesity-induced-cardiac-lipid-accumulation-in-adult-mice-is-modulated-by-g-protein-coupled-receptor-kinase-2-levels
#7
Elisa Lucas, Rocio Vila-Bedmar, Alba C Arcones, Marta Cruces-Sande, Victoria Cachofeiro, Federico Mayor, Cristina Murga
BACKGROUND: The leading cause of death among the obese population is heart failure and stroke prompted by structural and functional changes in the heart. The molecular mechanisms that underlie obesity-related cardiac remodeling are complex, and include hemodynamic and metabolic alterations that ultimately affect the functionality of the myocardium. G protein-coupled receptor kinase 2 (GRK2) is an ubiquitous kinase able to desensitize the active form of several G protein-coupled receptors (GPCR) and is known to play an important role in cardiac GPCR modulation...
November 10, 2016: Cardiovascular Diabetology
https://www.readbyqxmd.com/read/27832775/correlation-between-insulin-induced-estrogen-receptor-methylation-and-atherosclerosis
#8
Jia Min, Zhong Weitian, Cai Peng, Peng Yan, Zhang Bo, Wang Yan, Bai Yun, Wang Xukai
BACKGROUND: Hyperinsulinemia and insulin resistance have been recently recognized as an important cause of atherosclerosis. Clinical studies have also found that expression of the estrogen receptor is closely related to the incidence of atherosclerosis. This study investigate the effects of insulin and estrogen receptor α (ER-α) in atherosclerosis. METHODS: Double knockout ApoE/Lepr mice were given intraperitoneal injections of insulin, and their aortae were harvested for hematoxylin-eosin staining and immunohistochemical analysis...
November 10, 2016: Cardiovascular Diabetology
https://www.readbyqxmd.com/read/27814764/changes-in-triglycerides-and-high-density-lipoprotein-cholesterol-may-precede-peripheral-insulin-resistance-with-2-h-insulin-partially-mediating-this-unidirectional-relationship-a-prospective-cohort-study
#9
Tianshu Han, Yu Cheng, Shuang Tian, Li Wang, Xi Liang, Wei Duan, Lixin Na, Changhao Sun
BACKGROUND: Results of longitudinal researches regarding the temporal relationship between dyslipidemia and insulin resistance (IR) are inconsistent. This study assessed temporal relationships of blood lipids with IR and determined whether there are any mediating effects existed in these temporal relationships. METHODS: This study examined a longitudinal cohort of 3325 subjects aged 20-74 years from China with an average of 4.2 years follow-up. Measurements of fasting blood lipids, as well as fasting and 2-h serum glucose and insulin, were obtained at two time points...
November 4, 2016: Cardiovascular Diabetology
https://www.readbyqxmd.com/read/27809903/effect-of-trelagliptin-on-vascular-endothelial-functions-and-serum-adiponectin-level-in-patients-with-type-2-diabetes-a-preliminary-single-arm-prospective-pilot-study
#10
Satoshi Ida, Kazuya Murata, Katunori Betou, Chiaki Kobayashi, Yuki Ishihara, Kanako Imataka, Akihiro Uchida, Kou Monguchi, Ryutaro Kaneko, Ryoko Fujiwara, Hiroka Takahashi
BACKGROUND: Trelagliptin, an oral DPP-4 inhibitor, which is administered once per week and characterized by a long half-life in blood. The effects of trelagliptin on vascular endothelial functions have not been clarified to date. The objective of the present study was to examine the effects of trelagliptin on vascular endothelial functions in patients with type 2 diabetes mellitus (DM) using flow-mediated dilatation (FMD), adiponectin, and asymmetric dimethylarginine (ADMA) as evaluation indicators...
November 4, 2016: Cardiovascular Diabetology
https://www.readbyqxmd.com/read/27809851/cyclophilin-a-enhances-macrophage-differentiation-and-lipid-uptake-in-high-glucose-conditions-a-cellular-mechanism-for-accelerated-macro-vascular-disease-in-diabetes-mellitus
#11
Surya Ramachandran, Anandan Vinitha, Cheranellore Chandrasekharan Kartha
BACKGROUND: Vascular disease in diabetes is initiated by monocyte adhesion to vascular endothelium, transmigration and formation of foam cells. Increasing clinical evidence supports a role for the secretory protein, cyclophilin A in diabetic vascular disease. The means by which cyclophilin A contributes to vascular lesion development in diabetes is however largely unknown. METHODS: In this study we investigated using THP1 cells and human monocytes whether cyclophilin A under hyperglycemic conditions, functions in the inflammatory cascade as a chemoattractant and increases lipid uptake by formation of foam cells invitro...
November 3, 2016: Cardiovascular Diabetology
https://www.readbyqxmd.com/read/27809848/impact-of-glycemic-control-with-sitagliptin-on-the-2-year-progression-of-arterial-stiffness-a-sub-analysis-of-the-prologue-study
#12
Hirofumi Tomiyama, Takashi Miwa, Kenshi Kan, Munehide Matsuhisa, Haruo Kamiya, Mamoru Nanasato, Tomoki Kitano, Hiroaki Sano, Jun Ohno, Masato Iida, Masataka Sata, Hirotsugu Yamada, Koji Maemura, Atsushi Tanaka, Toyoaki Murohara, Koichi Node
BACKGROUND: No conclusive evidence has been obtained yet on the significance of the effects of dipeptidyl peptidase-4 (DPP-4 inhibitor) treatment on the arterial stiffness in clinical settings. In addition, the effects of good glycemic control on the arterial stiffness have also not been clarified yet. As a sub-analysis of the PROLOGUE study, we examined the effect of a DPP-4 inhibitor (sitagliptin) on the 2-year progression of the arterial stiffness and also to determine the effect of good glycemic control on the rate of progression of the arterial stiffness...
November 3, 2016: Cardiovascular Diabetology
https://www.readbyqxmd.com/read/27809845/impact-of-diabetes-on-the-predictive-value-of-heart-failure-biomarkers
#13
Nuria Alonso, Josep Lupón, Jaume Barallat, Marta de Antonio, Mar Domingo, Elisabet Zamora, Pedro Moliner, Amparo Galán, Javier Santesmases, Cruz Pastor, Dídac Mauricio, Antoni Bayes-Genis
BACKGROUND: Patients with diabetes mellitus (DM) have an increased risk of developing heart failure (HF). Further, DM is associated with poor prognosis in patients with HF. Our aim was to determine whether DM has any impact on the predictive value of a multi-biomarker panel in patients with HF. METHODS: We included 1069 consecutive ambulatory HF patients in the study: age 66.2 ± 12.8 years, 33.5 ± 13.3 left ventricular ejection fraction, 36% diabetic patients...
November 3, 2016: Cardiovascular Diabetology
https://www.readbyqxmd.com/read/27793156/metabolic-syndrome-is-independently-associated-with-increased-20-year-mortality-in-patients-with-stable-coronary-artery-disease
#14
Arwa Younis, Anan Younis, Boaz Tzur, Yael Peled, Nir Shlomo, Ilan Goldenberg, Enrique Z Fisman, Alexander Tenenbaum, Robert Klempfner
BACKGROUND: Data regarding long-term association of metabolic syndrome (MetS) with adverse outcomes are conflicting. We aim to determine the independent association of MetS (based on its different definitions) with 20 year all-cause mortality among patients with stable coronary artery disease (CAD). METHODS: Our study comprised 15,524 patients who were enrolled in the Bezafibrate Infarction Prevention registry between February 1, 1990, and October 31, 1992, and subsequently followed-up for the long-term mortality through December 31, 2014...
October 28, 2016: Cardiovascular Diabetology
https://www.readbyqxmd.com/read/27776526/association-of-metabolic-syndrome-and-its-components-with-arterial-stiffness-in-caucasian-subjects-of-the-mark-study-a-cross-sectional-trial
#15
Leticia Gomez-Sanchez, Luis Garcia-Ortiz, M Carmen Patino-Alonso, Jose I Recio-Rodriguez, Rigo Fernando, Ruth Marti, Cristina Agudo-Conde, Emiliano Rodriguez-Sanchez, Jose A Maderuelo-Fernandez, Rafel Ramos, Manuel A Gomez-Marcos
BACKGROUND: The cardio-ankle vascular index (CAVI) and brachial-ankle pulse wave velocity (baPWV) can reflect both central and peripheral arterial stiffness. Metabolic syndrome (MetS) and its components may increase arterial stiffness and the risk of cardiovascular diseases. However, the correlation of MetS and its components with arterial stiffness is still not clear. The primary aim of this study is thus the relationship using baPWV and CAVI in Caucasian adults with intermediate cardiovascular risk...
October 24, 2016: Cardiovascular Diabetology
https://www.readbyqxmd.com/read/27733159/moderate-intensity-statin-therapy-seems-ineffective-in-primary-cardiovascular-prevention-in-patients-with-type-2-diabetes-complicated-by-nephropathy-a-multicenter-prospective-8%C3%A2-years-follow-up-study
#16
Ferdinando Carlo Sasso, Nadia Lascar, Antonella Ascione, Ornella Carbonara, Luca De Nicola, Roberto Minutolo, Teresa Salvatore, Maria Rosaria Rizzo, Plinio Cirillo, Giuseppe Paolisso, Raffaele Marfella
BACKGROUND: Although numerous studies and metanalysis have shown the beneficial effect of statin therapy in CVD secondary prevention, there is still controversy such the use of statins for primary CVD prevention in patients with DM. The purpose of this study was to evaluate the occurrence of total major adverse cardio-vascular events (MACE) in a cohort of patients with type 2 diabetes complicated by nephropathy treated with statins, in order to verify real life effect of statin on CVD primary prevention...
October 13, 2016: Cardiovascular Diabetology
https://www.readbyqxmd.com/read/27733157/n-acetylcysteine-attenuates-myocardial-dysfunction-and-postischemic-injury-by-restoring-caveolin-3-enos-signaling-in-diabetic-rats
#17
Wating Su, Yuan Zhang, Qiongxia Zhang, Jinjin Xu, Liying Zhan, Qiqi Zhu, Qingquan Lian, Huimin Liu, Zhong-Yuan Xia, Zhengyuan Xia, Shaoqing Lei
BACKGROUND: Patients with diabetes are prone to develop cardiac hypertrophy and more susceptible to myocardial ischemia-reperfusion (I/R) injury, which are concomitant with hyperglycemia-induced oxidative stress and impaired endothelial nitric oxide (NO) synthase (eNOS)/NO signaling. Caveolae are critical in the transduction of eNOS/NO signaling in cardiovascular system. Caveolin (Cav)-3, the cardiomyocytes-specific caveolae structural protein, is decreased in the diabetic heart in which production of reactive oxygen species are increased...
October 12, 2016: Cardiovascular Diabetology
https://www.readbyqxmd.com/read/27729086/low-and-exacerbated-levels-of-1-5-anhydroglucitol-are-associated-with-cardiovascular-events-in-patients-after-first-time-elective-percutaneous-coronary-intervention
#18
Shuhei Takahashi, Kazunori Shimada, Katsumi Miyauchi, Tetsuro Miyazaki, Eiryu Sai, Manabu Ogita, Shuta Tsuboi, Hiroshi Tamura, Shinya Okazaki, Tomoyuki Shiozawa, Shohei Ouchi, Tatsuro Aikawa, Tomoyasu Kadoguchi, Hamad Al Shahi, Takuma Yoshihara, Makoto Hiki, Kikuo Isoda, Hiroyuki Daida
BACKGROUND: Postprandial hyperglycemia plays an important role in the pathogenesis of coronary artery disease and cardiovascular events. Serum 1,5-anhydroglucitol (1,5-AG) levels are known to be a clinical marker of postprandial hyperglycemia. However, the impact of 1,5-AG level on cardiovascular events has not been fully investigated. METHODS: We enrolled 240 consecutive patients who had undergone first-time elective percutaneous coronary intervention (PCI) with follow-up angiography within 1 year...
October 11, 2016: Cardiovascular Diabetology
https://www.readbyqxmd.com/read/27724869/combined-optical-coherence-tomography-morphologic-and-fractional-flow-reserve-hemodynamic-assessment-of-non-culprit-lesions-to-better-predict-adverse-event-outcomes-in-diabetes-mellitus-patients-combine-oct-ffr-prospective-study-rationale-and-design
#19
Mark W Kennedy, Enrico Fabris, Alexander J Ijsselmuiden, Holger Nef, Sebastian Reith, Javier Escaned, Fernando Alfonso, Niels van Royen, Wojtek Wojakowski, Adam Witkowski, Ciro Indolfi, Jan Paul Ottervanger, Harry Suryapranata, Elvin Kedhi
BACKGROUND: Fractional flow reserve (FFR) is a widely used tool for the identification of ischaemia-generating stenoses and to guide decisions on coronary revascularisation. However, the safety of FFR-based decisions in high-risk subsets, such as patients with Diabetes Mellitus (DM) or vulnerable stenoses presenting thin-cap fibro-atheroma (TCFA), is unknown. This study will examine the impact of optical coherence tomography (OCT) plaque morphological assessment and the identification of TCFA, in combination with FFR to better predict clinical outcomes in DM patients...
October 10, 2016: Cardiovascular Diabetology
https://www.readbyqxmd.com/read/27716289/vitamin-d-modifies-the-associations-between-circulating-betatrophin-and-cardiometabolic-risk-factors-among-youths-at-risk-for-metabolic-syndrome
#20
Junling Fu, Cong Hou, Lujiao Li, Dan Feng, Ge Li, Mingyao Li, Changhong Li, Shan Gao, Ming Li
BACKGROUND: Betatrophin has been recently reported to play a role in glucose homeostasis by inducing beta-cell proliferation in mice. However, studies in human are inconsistent. As a nutritionally-regulated liver-enriched factor, we hypothesize that betatrophin might be regulated by vitamin D, and ignorance of vitamin D status may explain the discrepancy in previous human studies. The aims of this study were to assess the association between circulating betatrophin and glucose homeostasis as well as other cardiometabolic variables in a cohort of youths at risk for metabolic syndrome and test the possible influence of vitamin D status on the association...
October 6, 2016: Cardiovascular Diabetology
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