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Biomedical Engineering Online

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https://www.readbyqxmd.com/read/28927417/automatic-sleep-staging-using-ear-eeg
#1
Kaare B Mikkelsen, David Bové Villadsen, Marit Otto, Preben Kidmose
BACKGROUND: Sleep and sleep quality assessment by means of sleep stage analysis is important for both scientific and clinical applications. Unfortunately, the presently preferred method, polysomnography (PSG), requires considerable expert assistance and significantly affects the sleep of the person under observation. A reliable, accurate and mobile alternative to the PSG would make sleep information much more readily available in a wide range of medical circumstances. NEW METHOD: Using an already proven method, ear-EEG, in which electrodes are placed inside the concha and ear canal, we measure cerebral activity and automatically score the sleep into up to five stages...
September 19, 2017: Biomedical Engineering Online
https://www.readbyqxmd.com/read/28923061/sinuscor-an-advanced-tool-for-heart-rate-variability-analysis
#2
Rhenan Bartels, Leonardo Neumamm, Tiago Peçanha, Alysson Roncally Silva Carvalho
BACKGROUND: Heart rate variability (HRV) is a widespread non-invasive technique to assess cardiac autonomic function. Time and frequency domain analyses have been used in HRV studies, and their interpretations are linked with both clinical prognostic and diagnostic information. Statistical and geometrical parameters, Fast Fourier Transform and Autoregressive based periodograms are commonly used approaches for the assessment of stationary RR intervals (RRi) signals. However, some conditions result in non-stationary HRV behavior such as the "tilt test" and exercise...
September 18, 2017: Biomedical Engineering Online
https://www.readbyqxmd.com/read/28865494/implementation-and-validation-of-the-extended-hill-type-muscle-model-with-robust-routing-capabilities-in-ls-dyna-for-active-human-body-models
#3
Christian Kleinbach, Oleksandr Martynenko, Janik Promies, Daniel F B Haeufle, Jörg Fehr, Syn Schmitt
BACKGROUND: In the state of the art finite element AHBMs for car crash analysis in the LS-DYNA software material named *MAT_MUSCLE (*MAT_156) is used for active muscles modeling. It has three elements in parallel configuration, which has several major drawbacks: restraint approximation of the physical reality, complicated parameterization and absence of the integrated activation dynamics. This study presents implementation of the extended four element Hill-type muscle model with serial damping and eccentric force-velocity relation including [Formula: see text] dependent activation dynamics and internal method for physiological muscle routing...
September 2, 2017: Biomedical Engineering Online
https://www.readbyqxmd.com/read/28851369/evaluation-of-the-effect-of-different-sitting-assistive-devices-in-reclining-wheelchair-on-interface-pressure
#4
Chun-Ting Li, Kuo-Yuan Huang, Chien-Feng Kung, Yen-Nien Chen, Yen-Ting Tseng, Kuen-Horng Tsai
BACKGROUND: Reclining wheelchair users often add one or more sitting assistive devices to their wheelchairs, but the effect of these additional sitting assistive devices on the risk of pressure ulcers has rarely been investigated. This study examined the four modes of reclining wheelchair without and with different sitting assistive devices, namely the back reclined mode, the lumbar support with back reclined mode, the femur upward with back reclined mode, and the lumbar support with femur upward with back reclined mode, in terms of their effects on human-wheelchair interface pressure...
August 29, 2017: Biomedical Engineering Online
https://www.readbyqxmd.com/read/28835251/noise-assisted-multivariate-empirical-mode-decomposition-for-multichannel-emg-signals
#5
Yi Zhang, Peng Xu, Peiyang Li, Keyi Duan, Yuexin Wen, Qin Yang, Tao Zhang, Dezhong Yao
BACKGROUND: Ensemble Empirical Mode Decomposition (EEMD) has been popularised for single-channel Electromyography (EMG) signal processing as it can effectively extract the temporal information of the EMG time series. However, few papers examine the temporal and spatial characteristics across multiple muscle groups in relation to multichannel EMG signals. EXPERIMENT: The experimental data was obtained from the Center for Machine Learning and Intelligent Systems, University of California Irvine (UCI)...
August 23, 2017: Biomedical Engineering Online
https://www.readbyqxmd.com/read/28830552/evaluation-of-cervical-posture-improvement-of-children-with-cerebral-palsy-after-physical-therapy-based-on-head-movements-and-serious-games
#6
Miguel A Velasco, Rafael Raya, Luca Muzzioli, Daniela Morelli, Abraham Otero, Marco Iosa, Febo Cincotti, Eduardo Rocon
BACKGROUND: This paper presents the preliminary results of a novel rehabilitation therapy for cervical and trunk control of children with cerebral palsy (CP) based on serious videogames and physical exercise. MATERIALS: The therapy is based on the use of the ENLAZA Interface, a head mouse based on inertial technology that will be used to control a set of serious videogames with movements of the head. METHODS: Ten users with CP participated in the study...
August 18, 2017: Biomedical Engineering Online
https://www.readbyqxmd.com/read/28830545/a-protocol-for-cabs-dock-protein-peptide-docking-driven-by-side-chain-contact-information
#7
Mateusz Kurcinski, Maciej Blaszczyk, Maciej Pawel Ciemny, Andrzej Kolinski, Sebastian Kmiecik
BACKGROUND: The characterization of protein-peptide interactions is a challenge for computational molecular docking. Protein-peptide docking tools face at least two major difficulties: (1) efficient sampling of large-scale conformational changes induced by binding and (2) selection of the best models from a large set of predicted structures. In this paper, we merge an efficient sampling technique with external information about side-chain contacts to sample and select the best possible models...
August 18, 2017: Biomedical Engineering Online
https://www.readbyqxmd.com/read/28830522/identification-of-informative-features-for-predicting-proinflammatory-potentials-of-engine-exhausts
#8
Chia-Chi Wang, Ying-Chi Lin, Yuan-Chung Lin, Syu-Ruei Jhang, Chun-Wei Tung
BACKGROUND: The immunotoxicity of engine exhausts is of high concern to human health due to the increasing prevalence of immune-related diseases. However, the evaluation of immunotoxicity of engine exhausts is currently based on expensive and time-consuming experiments. It is desirable to develop efficient methods for immunotoxicity assessment. METHODS: To accelerate the development of safe alternative fuels, this study proposed a computational method for identifying informative features for predicting proinflammatory potentials of engine exhausts...
August 18, 2017: Biomedical Engineering Online
https://www.readbyqxmd.com/read/28830520/automated-identification-of-reference-genes-based-on-rna-seq-data
#9
Rosario Carmona, Macarena Arroyo, María José Jiménez-Quesada, Pedro Seoane, Adoración Zafra, Rafael Larrosa, Juan de Dios Alché, M Gonzalo Claros
BACKGROUND: Gene expression analyses demand appropriate reference genes (RGs) for normalization, in order to obtain reliable assessments. Ideally, RG expression levels should remain constant in all cells, tissues or experimental conditions under study. Housekeeping genes traditionally fulfilled this requirement, but they have been reported to be less invariant than expected; therefore, RGs should be tested and validated for every particular situation. Microarray data have been used to propose new RGs, but only a limited set of model species and conditions are available; on the contrary, RNA-seq experiments are more and more frequent and constitute a new source of candidate RGs...
August 18, 2017: Biomedical Engineering Online
https://www.readbyqxmd.com/read/28830442/modeling-ephb4-ephrinb2-protein-protein-interaction-using-flexible-docking-of-a-short-linear-motif
#10
Maciej Pawel Ciemny, Mateusz Kurcinski, Maciej Blaszczyk, Andrzej Kolinski, Sebastian Kmiecik
BACKGROUND: Many protein-protein interactions are mediated by a short linear motif. Usually, amino acid sequences of those motifs are known or can be predicted. It is much harder to experimentally characterize or predict their structure in the bound form. In this work, we test a possibility of using flexible docking of a short linear motif to predict the interaction interface of the EphB4-EphrinB2 complex (a system extensively studied for its significance in tumor progression). METHODS: In the modeling, we only use knowledge about the motif sequence and experimental structures of EphB4-EphrinB2 complex partners...
August 18, 2017: Biomedical Engineering Online
https://www.readbyqxmd.com/read/28830438/feature-ranking-and-rank-aggregation-for-automatic-sleep-stage-classification-a-comparative-study
#11
Shirin Najdi, Ali Abdollahi Gharbali, José Manuel Fonseca
BACKGROUND: Nowadays, sleep quality is one of the most important measures of healthy life, especially considering the huge number of sleep-related disorders. Identifying sleep stages using polysomnographic (PSG) signals is the traditional way of assessing sleep quality. However, the manual process of sleep stage classification is time-consuming, subjective and costly. Therefore, in order to improve the accuracy and efficiency of the sleep stage classification, researchers have been trying to develop automatic classification algorithms...
August 18, 2017: Biomedical Engineering Online
https://www.readbyqxmd.com/read/28830434/rational-confederation-of-genes-and-diseases-ngs-interpretation-via-genecards-malacards-and-varelect
#12
Noa Rappaport, Simon Fishilevich, Ron Nudel, Michal Twik, Frida Belinky, Inbar Plaschkes, Tsippi Iny Stein, Dana Cohen, Danit Oz-Levi, Marilyn Safran, Doron Lancet
BACKGROUND: A key challenge in the realm of human disease research is next generation sequencing (NGS) interpretation, whereby identified filtered variant-harboring genes are associated with a patient's disease phenotypes. This necessitates bioinformatics tools linked to comprehensive knowledgebases. The GeneCards suite databases, which include GeneCards (human genes), MalaCards (human diseases) and PathCards (human pathways) together with additional tools, are presented with the focus on MalaCards utility for NGS interpretation as well as for large scale bioinformatic analyses...
August 18, 2017: Biomedical Engineering Online
https://www.readbyqxmd.com/read/28830433/transcranial-direct-current-stimulation-as-a-motor-neurorehabilitation-tool-an-empirical-review
#13
Ana Sánchez-Kuhn, Cristian Pérez-Fernández, Rosa Cánovas, Pilar Flores, Fernando Sánchez-Santed
The present review collects the most relevant empirical evidence available in the literature until date regarding the effects of transcranial direct current stimulation (tDCS) on the human motor function. tDCS in a non-invasive neurostimulation technique that delivers a weak current through the brain scalp altering the cortical excitability on the target brain area. The electrical current modulates the resting membrane potential of a variety of neuronal population (as pyramidal and gabaergic neurons); raising or dropping the firing rate up or down, depending on the nature of the electrode and the applied intensity...
August 18, 2017: Biomedical Engineering Online
https://www.readbyqxmd.com/read/28830427/influence-of-parameter-perturbations-on-the-reachability-of-therapeutic-target-in-systems-with-switchings
#14
Magdalena Ochab, Krzysztof Puszynski, Andrzej Swierniak
BACKGROUND: Examination of physiological processes and the influences of the drugs on them can be efficiently supported by mathematical modeling. One of the biggest problems is related to the exact fitting of the parameters of a model. Conditions inside the organism change dynamically, so the rates of processes are very difficult to estimate. Perturbations in the model parameters influence the steady state so a desired therapeutic goal may not be reached. Here we investigate the effect of parameter deviation on the steady state in three simple models of the influence of a therapeutic drug on its target protein...
August 18, 2017: Biomedical Engineering Online
https://www.readbyqxmd.com/read/28830426/using-random-forests-for-assistance-in-the-curation-of-g-protein-coupled-receptor-databases
#15
Aleksei Shkurin, Alfredo Vellido
BACKGROUND: Biology is experiencing a gradual but fast transformation from a laboratory-centred science towards a data-centred one. As such, it requires robust data engineering and the use of quantitative data analysis methods as part of database curation. This paper focuses on G protein-coupled receptors, a large and heterogeneous super-family of cell membrane proteins of interest to biology in general. One of its families, Class C, is of particular interest to pharmacology and drug design...
August 18, 2017: Biomedical Engineering Online
https://www.readbyqxmd.com/read/28821242/methodological-factors-affecting-joint-moments-estimation-in-clinical-gait-analysis-a-systematic-review
#16
REVIEW
Valentina Camomilla, Andrea Cereatti, Andrea Giovanni Cutti, Silvia Fantozzi, Rita Stagni, Giuseppe Vannozzi
Quantitative gait analysis can provide a description of joint kinematics and dynamics, and it is recognized as a clinically useful tool for functional assessment, diagnosis and intervention planning. Clinically interpretable parameters are estimated from quantitative measures (i.e. ground reaction forces, skin marker trajectories, etc.) through biomechanical modelling. In particular, the estimation of joint moments during motion is grounded on several modelling assumptions: (1) body segmental and joint kinematics is derived from the trajectories of markers and by modelling the human body as a kinematic chain; (2) joint resultant (net) loads are, usually, derived from force plate measurements through a model of segmental dynamics...
August 18, 2017: Biomedical Engineering Online
https://www.readbyqxmd.com/read/28810871/effect-of-different-inner-core-diameters-on-structural-strength-of-cannulated-pedicle-screws-under-various-lumbar-spine-movements
#17
Chia-Ming Chang, Yu-Shu Lai, Cheng-Kung Cheng
BACKGROUND: Currently, cannulated pedicle screws have been widely used in minimal invasive or navigation techniques. However, the stress distribution and the strength of different core diameters of cannulated screw are not clear. This study aimed to investigate the mechanical strength of cannulated screws with different inner core diameter under various lumbar spine movements using finite element analysis. RESULTS: The results showed that the von-Mises stress of a cannulated screw was larger than that of a solid screw in all loading conditions, especially above 2 mm in cannulated core diameter...
August 15, 2017: Biomedical Engineering Online
https://www.readbyqxmd.com/read/28806960/16-channel-biphasic-current-mode-programmable-charge-balanced-neural-stimulation
#18
Xiaoran Li, Shunan Zhong, James Morizio
BACKGROUND: Neural stimulation is an important method used to activate or inhibit action potentials of the neuronal anatomical targets found in the brain, central nerve and peripheral nerve. The neural stimulator system produces biphasic pulses that deliver balanced charge into tissue from single or multichannel electrodes. The timing and amplitude of these biphasic pulses are precisely controlled by the neural stimulator software or imbedded algorithms. Amplitude mismatch between the anodic current and cathodic current of the biphasic pulse will cause permanently damage for the neural tissues...
August 14, 2017: Biomedical Engineering Online
https://www.readbyqxmd.com/read/28800744/physiological-artifacts-in-scalp-eeg-and-ear-eeg
#19
Simon L Kappel, David Looney, Danilo P Mandic, Preben Kidmose
BACKGROUND: A problem inherent to recording EEG is the interference arising from noise and artifacts. While in a laboratory environment, artifacts and interference can, to a large extent, be avoided or controlled, in real-life scenarios this is a challenge. Ear-EEG is a concept where EEG is acquired from electrodes in the ear. METHODS: We present a characterization of physiological artifacts generated in a controlled environment for nine subjects. The influence of the artifacts was quantified in terms of the signal-to-noise ratio (SNR) deterioration of the auditory steady-state response...
August 11, 2017: Biomedical Engineering Online
https://www.readbyqxmd.com/read/28789685/remote-monitoring-of-cardiorespiratory-signals-from-a-hovering-unmanned-aerial-vehicle
#20
Ali Al-Naji, Asanka G Perera, Javaan Chahl
BACKGROUND: Remote physiological measurement might be very useful for biomedical diagnostics and monitoring. This study presents an efficient method for remotely measuring heart rate and respiratory rate from video captured by a hovering unmanned aerial vehicle (UVA). The proposed method estimates heart rate and respiratory rate based on the acquired signals obtained from video-photoplethysmography that are synchronous with cardiorespiratory activity. METHODS: Since the PPG signal is highly affected by the noise variations (illumination variations, subject's motions and camera movement), we have used advanced signal processing techniques, including complete ensemble empirical mode decomposition with adaptive noise (CEEMDAN) and canonical correlation analysis (CCA) to remove noise under these assumptions...
August 8, 2017: Biomedical Engineering Online
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