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Biomedical Engineering Online

Alex M Santos, Anselmo C Paiva, Adriana P M Santos, Steve A T Mpinda, Daniel L Gomes, Aristófanes C Silva, Geraldo Braz, João Dallyson S de Almeida, Marcelo Gattas
After publication, it was highlighted that the original publication [1] contained a spelling mistake in the first name of Marcelo Gattas. This was incorrectly captured as Marelo Gattass in the original article which has since been updated.
November 8, 2018: Biomedical Engineering Online
Chan-Young Park, Jun Yeon, Hye-Jeong Song, Yu-Seop Kim, Ki-Bong Nahm, Jong-Dae Kim
BACKGROUND: The accuracy and precision of liquid handling can be altered by several causes including wearing or failure of parts, and human error. The last cause is crucial since point-of-care testing (POCT) devices can be used by non-experienced users or patients themselves. Therefore it is important to improve the method of informing the users of POCT device malfunctions due to damage of parts or human error. METHODS: In this paper, image-based failure monitoring of the automated pipetting was introduced for POCT devices...
November 6, 2018: Biomedical Engineering Online
Jong-Dae Kim, So-Yeon Lee, Yu-Seop Kim, Hye-Jeong Song, Chan-Young Park
BACKGROUND: In this paper, we propose a system for data monitoring and control of polymerase chain reaction (PCR) externally. PCR is a technique for amplifying a desired DNA molecule by repeatedly synthesizing a specific part of DNA sequence. Currently, commercially available systems are standalone systems or operate PCR devices through a computer in the vicinity of devices for control purposes. These systems are limited in the number of devices that the host system can monitor at the same time, and there are limitations in controlling devices or accessing experimental data externally...
November 6, 2018: Biomedical Engineering Online
Deuk-Ju Lee, Jong-Dae Kim, Yu-Seop Kim, Hye-Jeong Song, Chan-Young Park
BACKGROUND: In general, the image analysis of nucleic acid for detecting DNA is dependent on the gel documentation system. These experiments may deal with harmful staining agents and are time consuming. To address these issues, real-time polymerase chain reaction (PCR) devices have been developed. The advantages of real-time PCR are its capabilities for real-time diagnosis, improved sensitivity, and digitization of measurement results. However, real-time PCR equipment is still too bulky and expensive for use in small hospitals and laboratories...
November 6, 2018: Biomedical Engineering Online
Ji-Soo Hwang, Jong-Dae Kim, Yu-Seop Kim, Hye-Jeong Song, Chan-Young Park
BACKGROUND: Polymerase chain reaction (PCR) is used in nucleic acid tests of infectious diseases in point-of-care testing. Previous studies have demonstrated real-time PCR that uses a micro-PCR chip made of packing tape, double-sided tape, and a plastic cover with polycarbonate or polypropylene on a black matte printed circuit board substrate. Despite the success of DNA amplification and fluorescence detection using an early version of the micro-PCR chip, reaching the target temperature was fairly slow and, as a result, the total running time was getting longer...
November 6, 2018: Biomedical Engineering Online
Chang-Young Park, Young-Hyun Park, Yu-Seop Kim, Hye-Jeong Song, Jong-Dae Kim
BACKGROUND: Recently, automatic molecular diagnostic devices to extract DNA have been extensively developed using magnetic beads. While various methods can be applied to the control of the beads, the efficiency of the control when incorporated in automatic devices has not been studied. This paper proposes a compact magnet actuation method for the control of magnetic beads for DNA extraction, and compares the efficiency to the already available magnetic bead-based DNA extraction device...
November 6, 2018: Biomedical Engineering Online
Cheung-Hwa Hsu, Chao-Hui Ou, Wei-Lun Hong, Yu-Han Gao
BACKGROUND: In the past, manufacture of prosthetic socket by using traditional handmade method not only consumed research time but also required a special assembly approach. Recently, reverse engineering and rapid prototype technology have grown up explosively, and thus, provide a choice to fabricate prosthetic socket. METHODS: Application 3D computer aided design and manufacturing (computer-aided design/computer-aided engineering) tools approach the surface shape stump data is digitized and can be easily modified and reused...
November 6, 2018: Biomedical Engineering Online
Rong-Shue Hsiao, Tian-Xiang Chen, Mekuanint Agegnehu Bitew, Chun-Hao Kao, Tzu-Yu Li
BACKGROUND: Pressure sensors have been used for sleeping posture detection, which meet privacy requirements. Most of the existing techniques for sleeping posture recognition used force-sensitive resistor (FSR) sensors. However, lower limbs cannot be recognized accurately unless thousands of sensors are deployed on the bedsheet. METHOD: We designed a sleeping posture recognition scheme in which FSR sensors were deployed on the upper part of the bedsheet to record the pressure distribution of the upper body...
November 6, 2018: Biomedical Engineering Online
Yi-Horng Lai
BACKGROUND: Dengue fever is a leading cause of severe illness and hospitalization in Taiwan. This study sought to elucidate the linkage between dengue fever incidence and climate factors. RESULTS: The result indicated that temperature, accumulated rainfall, and sunshine play an important role in the transmission cycles of dengue fever. A predictive model equation plots dengue fever incidence versus temperature, rainfall, and sunshine, and it suggests that temperature, rainfall, and sunshine are significantly correlated with dengue fever incidence...
November 6, 2018: Biomedical Engineering Online
Hye-Jeong Song, Byeong-Hun Yoon, Young-Shin Youn, Chan-Young Park, Jong-Dae Kim, Yu-Seop Kim
BACKGROUND: One of the most important processes in a machine learning-based natural language processing is to represent words. The one-hot representation that has been commonly used has a large size of vector and assumes that the features that make up the vector are independent of each other. On the other hand, it is known that word embedding has a great effect in estimating the similarity between words because it expresses the meaning of the word well. In this study, we try to clarify the correlation between various terms in the biomedical texts based on the excellent ability of estimating similarity between words shown by word embedding...
November 6, 2018: Biomedical Engineering Online
Ga Young Kim, Ju Hwan Lee, Yoo Na Hwang, Sung Min Kim
BACKGROUND: Intravascular ultrasound (IVUS) is a commonly used diagnostic imaging method for coronary artery disease. Virtual histology (VH) characterizes the plaque components into fibrous tissue (FT), fibro-fatty tissue (FFT), necrotic core (NC), or dense calcium (DC). However, VH can obtain only a single-frame image in one cardiac cycle, and specific software is needed to obtain the radio frequency data. This study proposed a novel intensity-based multi-level classification model for plaque characterization...
November 6, 2018: Biomedical Engineering Online
Ching-Hsiu Hsieh, Chi-Chuan Tseng, Ju-Yu Shen, Pei-Ying Chuang
BACKGROUND: The purpose of this study was to investigate the efficacy of moxibustion therapy on weight loss, waist circumference and waist-to-hip ratio in young adult females. An experimental design, 51 Asian females were enrolled. Inclusion criteria included females with ages between 21 and 25 years-old and waist circumference ≥ 80 cm, and the exclusion criteria included intolerance to moxibustion therapy and current illness. Two groups were formed, and the subjects in the experimental group received moxibustion sessions lasting 20 min and an educational video program for 30 min; however, participants in the control group received only the educational program every other week for 8 weeks...
November 6, 2018: Biomedical Engineering Online
Wei-Hua Tang, Wen-Hsien Ho, Yenming J Chen
BACKGROUND: This study estimates atrial repolarization activities (Ta waves), which are typically hidden most of the time from body surface electrocardiography when diagnosing cardiovascular diseases. The morphology of Ta waves has been proven to be an important marker for the early sign of inferior injury, such as acute atrial infarction, or arrhythmia, such as atrial fibrillation. However, Ta waves are usually unseen except during conduction system malfunction, such as long QT interval or atrioventricular block...
November 6, 2018: Biomedical Engineering Online
Hye-Jeong Song, Eun-Suk Yang, Jong-Dae Kim, Chan-Young Park, Min-Sun Kyung, Yu-Seop Kim
BACKGROUND: Screening test using CA-125 is the most common test for detecting ovarian cancer. However, the level of CA-125 is diverse by variable condition other than ovarian cancer. It has led to misdiagnosis of ovarian cancer. METHODS: In this paper, we explore the 16 serum biomarker for finding alternative biomarker combination to reduce misdiagnosis. For experiment, we use the serum samples that contain 101 cancer and 92 healthy samples. We perform two major tasks: Marker selection and Classification...
November 6, 2018: Biomedical Engineering Online
Hye-Jeong Song, Byeong-Cheol Jo, Chan-Young Park, Jong-Dae Kim, Yu-Seop Kim
BACKGROUND: Biomedical named entity recognition (Bio-NER) is a fundamental task in handling biomedical text terms, such as RNA, protein, cell type, cell line, and DNA. Bio-NER is one of the most elementary and core tasks in biomedical knowledge discovery from texts. The system described here is developed by using the BioNLP/NLPBA 2004 shared task. Experiments are conducted on a training and evaluation set provided by the task organizers. RESULTS: Our results show that, compared with a baseline having a 70...
November 6, 2018: Biomedical Engineering Online
Cheng-Fa Chiang, Fang-Ming Hsu, Kuo-Hui Yeh
BACKGROUND: The significant advancement in the mobile sensing technologies has brought great interests on application development for the Internet-of-Things (IoT). With the advantages of contactlessness data retrieval and efficient data processing of intelligent IoT-based objects, versatile innovative types of on-demand medical relevant services have promptly been developed and deployed. Critical characteristics involved within the data processing and operation must thoroughly be considered...
November 6, 2018: Biomedical Engineering Online
Wei-Hua Tang, Wen-Hsien Ho, Yenming J Chen
Biological and medical diagnoses depend on high-quality measurements. A wearable device based on Internet of Things (IoT) must be unobtrusive to the human body to encourage users to accept continuous monitoring. However, unobtrusive IoT devices are usually of low quality and unreliable because of the limitation of technology progress that has slowed down at high peak. Therefore, advanced inference techniques must be developed to address the limitations of IoT devices. This review proposes that IoT technology in biological and medical applications should be based on a new data assimilation process that fuses multiple data scales from several sources to provide diagnoses...
November 6, 2018: Biomedical Engineering Online
Xiao Wang, Liuye Yao, Yuemei Zhao, Lidong Xing, Zhiyu Qian, Weitao Li, Yamin Yang
BACKGROUND: Discomfort evoked by stereoscopic depth has been widely concerned. Previous studies have proposed a comfortable disparity range and considered that disparities exceed this range would cause visual discomfort. Brain activity recordings including Electroencephalograph (EEG) monitoring enable better understanding of perceptual and cognitive processes related to stereo depth-induced visual comfort. METHODS: EEG data was collected using a stereo-visual evoked potential (VEP) test system by providing visual stimulus to subjects aged from 21 to 25 with normal stereoscopic vision...
November 3, 2018: Biomedical Engineering Online
Yuqiang Bai, William Ngo, Boyu Gu, Yuhua Zhang, Jason J Nichols
BACKGROUND: The outermost layer of the tear film consists of a thin lipid layer (LL). The lipid layer serves as a barrier against evaporation of the aqueous component of the tear film. The ability to simultaneously image both the lipid layer thickness and overall tear film thickness is novel, and will help further understandings of mechanisms of how the lipid layer assembles and interacts with the full tear film thickness. METHODS: We developed a system that combines simultaneous optical coherence tomography (OCT) and thickness dependent fringes (TDF) interferometry for in vivo imaging of the tear film...
November 1, 2018: Biomedical Engineering Online
Wenbao Wu, Wei Zeng, Limin Ma, Chengzhi Yuan, Yu Zhang
BACKGROUND: The anterior cruciate ligament (ACL) plays an important role in stabilizing translation and rotation of the tibia relative to the femur. ACL injury alters knee kinematics and usually links to the alternation of gait patterns. The aim of this study is to develop a new method to distinguish between gait patterns of patients with anterior cruciate ligament deficient (ACL-D) knees and healthy controls with ACL-intact (ACL-I) knees based on nonlinear features and neural networks...
November 1, 2018: Biomedical Engineering Online
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