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Biomedical Engineering Online

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https://www.readbyqxmd.com/read/28705250/effect-of-manufacturing-and-experimental-conditions-on-the-mechanical-and-surface-properties-of-silicone-elastomer-scaffolds-used-in-endothelial-mechanobiological-studies
#1
Marc-Antoine Campeau, Audrey Lortie, Pierrick Tremblay, Marc-Olivier Béliveau, Dominic Dubé, Ève Langelier, Léonie Rouleau
BACKGROUND: Mechanobiological studies allow the characterization of cell response to mechanical stresses. Cells need to be supported by a material with properties similar to the physiological environment. Silicone elastomers have been used to produce various in vitro scaffolds of different geometries for endothelial cell studies given its relevant mechanical, optical and surface properties. However, obtaining defined and repeatable properties is a challenge as depending on the different manufacturing and processing steps, mechanical and surface properties may vary significantly between research groups...
July 14, 2017: Biomedical Engineering Online
https://www.readbyqxmd.com/read/28679415/classification-of-caesarean-section-and-normal-vaginal-deliveries-using-foetal-heart-rate-signals-and-advanced-machine-learning-algorithms
#2
Paul Fergus, Abir Hussain, Dhiya Al-Jumeily, De-Shuang Huang, Nizar Bouguila
BACKGROUND: Visual inspection of cardiotocography traces by obstetricians and midwives is the gold standard for monitoring the wellbeing of the foetus during antenatal care. However, inter- and intra-observer variability is high with only a 30% positive predictive value for the classification of pathological outcomes. This has a significant negative impact on the perinatal foetus and often results in cardio-pulmonary arrest, brain and vital organ damage, cerebral palsy, hearing, visual and cognitive defects and in severe cases, death...
July 6, 2017: Biomedical Engineering Online
https://www.readbyqxmd.com/read/28676056/investigation-of-implantable-signal-transmission-characteristics-based-on-visible-data-of-the-human-leg
#3
Yue-Ming Gao, Yan-Ting Ye, Shi Lin, Željka Lučev Vasić, Mang-I Vai, Min Du, Mario Cifrek, Sio-Hang Pun
BACKGROUND: Signal transmission characteristics between implanted medical devices and external equipment has been a common key issue, as has the problem of supplying energy to the devices. It can be used to enable signal transmission from implanted devices that the human body's conductive properties. Using signal transmission by galvanic coupling is one of the most effective signal transmission methods. METHODS: The signal transmission characteristics by galvanic coupling of implantable devices using a frequency range of 10 kHz to 1 MHz was analyzed in this article...
July 4, 2017: Biomedical Engineering Online
https://www.readbyqxmd.com/read/28659191/an-ultrasound-transient-elastography-system-with-coded-excitation
#4
Xianfen Diao, Jing Zhu, Xiaonian He, Xin Chen, Xinyu Zhang, Siping Chen, Weixiang Liu
BACKGROUND: Ultrasound transient elastography technology has found its place in elastography because it is safe and easy to operate. However, it's application in deep tissue is limited. The aim of this study is to design an ultrasound transient elastography system with coded excitation to obtain greater detection depth. METHODS: The ultrasound transient elastography system requires tissue vibration to be strictly synchronous with ultrasound detection. Therefore, an ultrasound transient elastography system with coded excitation was designed...
June 28, 2017: Biomedical Engineering Online
https://www.readbyqxmd.com/read/28655316/reconstruction-of-fluorescence-molecular-tomography-with-a-cosinoidal-level-set-method
#5
Xuanxuan Zhang, Xu Cao, Shouping Zhu
BACKGROUND: Implicit shape-based reconstruction method in fluorescence molecular tomography (FMT) is capable of achieving higher image clarity than image-based reconstruction method. However, the implicit shape method suffers from a low convergence speed and performs unstably due to the utilization of gradient-based optimization methods. Moreover, the implicit shape method requires priori information about the number of targets. METHODS: A shape-based reconstruction scheme of FMT with a cosinoidal level set method is proposed in this paper...
June 27, 2017: Biomedical Engineering Online
https://www.readbyqxmd.com/read/28651645/lead-field-theory-provides-a-powerful-tool-for-designing-microelectrode-array-impedance-measurements-for-biological-cell-detection-and-observation
#6
Marcel Böttrich, Jarno M A Tanskanen, Jari A K Hyttinen
BACKGROUND: Our aim is to introduce a method to enhance the design process of microelectrode array (MEA) based electric bioimpedance measurement systems for improved detection and viability assessment of living cells and tissues. We propose the application of electromagnetic lead field theory and reciprocity for MEA design and measurement result interpretation. Further, we simulated impedance spectroscopy (IS) with two- and four-electrode setups and a biological cell to illustrate the tool in the assessment of the capabilities of given MEA electrode constellations for detecting cells on or in the vicinity of the microelectrodes...
June 26, 2017: Biomedical Engineering Online
https://www.readbyqxmd.com/read/28651592/anatomic-comparison-of-veins-of-labb%C3%A3-between-autopsy-digital-subtraction-angiography-and-computed-tomographic-venography
#7
Qiong Fang, Anhong Jiang, Wei Tao, Lin Xin
OBJECTIVE: The drainage portion of the vein of Labbé varies, and it is difficult to predict whether the operation is likely to damage this vein. The aim of this study was to correlate the microanatomy of the vein of Labbé with digital subtraction angiography (DSA) and computed tomographic venography (CTV), in order to provide a basis for the preservation of the vein of Labbé during a supratentorial surgical approach. METHODS: A total of 30 human cadavers (60 sides) and 61 living patients (110 sides) were examined in this study...
June 26, 2017: Biomedical Engineering Online
https://www.readbyqxmd.com/read/28651585/a-vessel-length-based-method-to-compute-coronary-fractional-flow-reserve-from-optical-coherence-tomography-images
#8
Kyung Eun Lee, Seo Ho Lee, Eun-Seok Shin, Eun Bo Shim
BACKGROUND: Hemodynamic simulation for quantifying fractional flow reserve (FFR) is often performed in a patient-specific geometry of coronary arteries reconstructed from the images from various imaging modalities. Because optical coherence tomography (OCT) images can provide more precise vascular lumen geometry, regardless of stenotic severity, hemodynamic simulation based on OCT images may be effective. The aim of this study is to perform OCT-FFR simulations by coupling a 3D CFD model from geometrically correct OCT images with a LPM based on vessel lengths extracted from CAG data with clinical validations for the present method...
June 26, 2017: Biomedical Engineering Online
https://www.readbyqxmd.com/read/28646865/development-of-stereo-endoscope-system-with-its-innovative-master-interface-for-continuous-surgical-operation
#9
Myungjoon Kim, Chiwon Lee, Nhayoung Hong, Yoon Jae Kim, Sungwan Kim
BACKGROUND: Although robotic laparoscopic surgery has various benefits when compared with conventional open surgery and minimally invasive surgery, it also has issues to overcome and one of the issues is the discontinuous surgical flow that occurs whenever control is swapped between the endoscope system and the operating robot arm system. This can lead to problems such as collision between surgical instruments, injury to patients, and increased operation time. To achieve continuous surgical operation, a wireless controllable stereo endoscope system is proposed which enables the simultaneous control of the operating robot arm system and the endoscope system...
June 24, 2017: Biomedical Engineering Online
https://www.readbyqxmd.com/read/28646862/a-clinical-utility-assessment-of-the-automatic-measurement-method-of-the-quality-of-meibomian-glands
#10
Robert Koprowski, Lei Tian, Paweł Olczyk
BACKGROUND: Meibomian gland dysfunction (MGD) is one of the most common diseases observed in clinics and is the leading cause of evaporative dry eye. Today, diagnostics of MGD is not fully automatic yet and is based on a qualitative assessment made by an ophthalmologist. Therefore, an automatic analysis method was developed to assess MGD quantiatively. MATERIALS: The analysis made use of 228 images of 57 patients recorded by OCULUS Keratograph(®) 5 M with a resolution of 1024 × 1360 pixels concern 30 eyes of healthy individuals (14 women and 16 men) and 27 eyes of sick patients (10 women and 17 men)...
June 24, 2017: Biomedical Engineering Online
https://www.readbyqxmd.com/read/28629374/multi-purpose-ecg-telemetry-system
#11
Mohamed Marouf, Goran Vukomanovic, Lazar Saranovac, Miroslav Bozic
BACKGROUND: The Electrocardiogram ECG is one of the most important non-invasive tools for cardiac diseases diagnosis. Taking advantage of the developed telecommunication infrastructure, several approaches that address the development of telemetry cardiac devices were introduced recently. Telemetry ECG devices allow easy and fast ECG monitoring of patients with suspected cardiac issues. Choosing the right device with the desired working mode, signal quality, and the device cost are still the main obstacles to massive usage of these devices...
June 19, 2017: Biomedical Engineering Online
https://www.readbyqxmd.com/read/28610609/estimation-of-basic-reproduction-number-of-the-middle-east-respiratory-syndrome-coronavirus-mers-cov-during-the-outbreak-in-south-korea-2015
#12
Hyuk-Jun Chang
BACKGROUND: In South Korea, an outbreak of Middle East respiratory syndrome (MERS) occurred in 2015. It was the second largest MERS outbreak. As a result of the outbreak in South Korea, 186 infections were reported, and 36 patients died. At least 16,693 people were isolated with suspicious symptoms. This paper estimates the basic reproduction number of the MERS coronavirus (CoV), using data on the spread of MERS in South Korea. METHODS: The basic reproduction number of an epidemic is defined as the average number of secondary cases that an infected subject produces over its infectious period in a susceptible and uninfected population...
June 13, 2017: Biomedical Engineering Online
https://www.readbyqxmd.com/read/28595607/a-composite-visualization-method-for-electrophysiology-morphous-merging-of-human-heart
#13
Fei Yang, Lei Zhang, Weigang Lu, Yue Zhang, Wangmeng Zuo, Kuanquan Wang, Henggui Zhang
BACKGROUND: Electrophysiological behavior is of great importance for analyzing the cardiac functional mechanism under cardiac physiological and pathological condition. Due to the complexity of cardiac structure and biophysiological function, visualization of a cardiac electrophysiological model compositively is still a challenge. The lack of either modality of the whole organ structure or cardiac electrophysiological behaviors makes analysis of the intricate mechanisms of cardiac dynamic function a difficult task...
June 8, 2017: Biomedical Engineering Online
https://www.readbyqxmd.com/read/28592309/machine-learning-techniques-for-diabetic-macular-edema-dme-classification-on-sd-oct-images
#14
Khaled Alsaih, Guillaume Lemaitre, Mojdeh Rastgoo, Joan Massich, Désiré Sidibé, Fabrice Meriaudeau
BACKGROUND: Spectral domain optical coherence tomography (OCT) (SD-OCT) is most widely imaging equipment used in ophthalmology to detect diabetic macular edema (DME). Indeed, it offers an accurate visualization of the morphology of the retina as well as the retina layers. METHODS: The dataset used in this study has been acquired by the Singapore Eye Research Institute (SERI), using CIRRUS TM (Carl Zeiss Meditec, Inc., Dublin, CA, USA) SD-OCT device. The dataset consists of 32 OCT volumes (16 DME and 16 normal cases)...
June 7, 2017: Biomedical Engineering Online
https://www.readbyqxmd.com/read/28592292/effects-of-amiodarone-on-short-qt-syndrome-variant-3-in-human-ventricles-a-simulation-study
#15
Cunjin Luo, Kuanquan Wang, Henggui Zhang
BACKGROUND: Short QT syndrome (SQTS) is a newly identified clinical disorder associated with atrial and/or ventricular arrhythmias and increased risk of sudden cardiac death (SCD). The SQTS variant 3 is linked to D172N mutation to the KCNJ2 gene that causes a gain-of-function to the inward rectifier potassium channel current (I K1), which shortens the ventricular action potential duration (APD) and effective refractory period (ERP). Pro-arrhythmogenic effects of SQTS have been characterized, but less is known about the possible pharmacological treatment of SQTS...
June 7, 2017: Biomedical Engineering Online
https://www.readbyqxmd.com/read/28592331/thyroid-nodule-recognition-in-computed-tomography-using-first-order-statistics
#16
Wenxian Peng, Chenbin Liu, Shunren Xia, Dangdang Shao, Yihong Chen, Rui Liu, Zhiping Zhang
BACKGROUND: Computed tomography (CT) is one of the popular tools for early detection of thyroid nodule. The pixel intensity of thyroid in CT image is very important information to distinguish nodule from normal thyroid tissue. The pixel intensity in normal thyroid tissues is homogeneous and smooth. In the benign or malignant nodules, the pixel intensity is heterogeneous. Several studies have shown that the first order features in ultrasound image can be used as imaging biomarkers in nodule recognition...
June 2, 2017: Biomedical Engineering Online
https://www.readbyqxmd.com/read/28558778/test-retest-reliability-of-mandibular-morphology-measurements-on-cone-beam-computed-tomography-synthesized-cephalograms-with-random-head-positioning-errors
#17
Hsien-Shu Lin, Yunn-Jy Chen, Hsuan-Lun Lu, Tung-Wu Lu, Chien-Chih Chen
BACKGROUND: Cephalometric radiography has been used for orthodontic and surgical treatment planning and assessment, and for quantifying mandibular growth. However, it remains unclear how head positioning errors and the level of examiner experience affect the reliability of such morphometric measurements. The current study aimed to bridge the gap by determining the intra-, inter-rater, and inter-session reliability of measurements of mandibular morphology with random head positioning errors as measured by a junior and a senior dentist...
May 30, 2017: Biomedical Engineering Online
https://www.readbyqxmd.com/read/28558773/magnetic-inductive-phase-shift-a-new-method-to-differentiate-hemorrhagic-stroke-from-ischemic-stroke-on-rabbit
#18
Qingguang Yan, Gui Jin, Ke Ma, Mingxin Qin, Wei Zhuang, Jian Sun
BACKGROUND: The major therapy for ischemic stroke is thrombolytic treatment, but severe consequences occur when this method is used to treat hemorrhagic stroke. Currently, computed tomography and magnetic resonance imaging are used to differentiate between two types of stroke, but these two methods are ineffective for pre-hospital care. METHODS: We developed a new brain diagnostic device for rabbits based on electromagnetic induction to non-invasively differentiate two types of stroke...
May 30, 2017: Biomedical Engineering Online
https://www.readbyqxmd.com/read/28558769/a-photoacoustic-imaging-reconstruction-method-based-on-directional-total-variation-with-adaptive-directivity
#19
Jin Wang, Chen Zhang, Yuanyuan Wang
BACKGROUND: In photoacoustic tomography (PAT), total variation (TV) based iteration algorithm is reported to have a good performance in PAT image reconstruction. However, classical TV based algorithm fails to preserve the edges and texture details of the image because it is not sensitive to the direction of the image. Therefore, it is of great significance to develop a new PAT reconstruction algorithm to effectively solve the drawback of TV. METHODS: In this paper, a directional total variation with adaptive directivity (DDTV) model-based PAT image reconstruction algorithm, which weightedly sums the image gradients based on the spatially varying directivity pattern of the image is proposed to overcome the shortcomings of TV...
May 30, 2017: Biomedical Engineering Online
https://www.readbyqxmd.com/read/28532491/evaluation-of-an-automated-thresholding-algorithm-for-the-quantification-of-paraspinal-muscle-composition-from-mri-images
#20
Maryse Fortin, Mona Omidyeganeh, Michele Crites Battié, Omair Ahmad, Hassan Rivaz
BACKGROUND: The imaging assessment of paraspinal muscle morphology and fatty infiltration has gained considerable attention in the past decades, with reports suggesting an association between muscle degenerative changes and low back pain (LBP). To date, qualitative and quantitative approaches have been used to assess paraspinal muscle composition. Though highly reliable, manual thresholding techniques are time consuming and not always feasible in a clinical setting. The tedious and rater-dependent nature of such manual thresholding techniques provides the impetus for the development of automated or semi-automated segmentation methods...
May 22, 2017: Biomedical Engineering Online
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