Behrouz Robat-Jazi, Mona Oraei, Sama Bitarafan, Seyed Alireza Mesbah-Namin, Ali Noori-Zadeh, Fatemeh Mansouri, Karim Parastouei, Ali Anissian, Mir Saeed Yekaninejad, Ali Akbar Saboor Yaraghi
Previous studies noted an imbalance in T helper (Th) 17 and regulatory T cells (Tregs) in experimental autoimmune encephalomyelitis (EAE), a multiple sclerosis animal model. calcitriol, vitamin D's active form, was found to ameliorate EAE symptoms by favoring Tregss over Th17 cells, suggesting immunomodulatory effects. This study aimed to assess calcitriol's impact on EAE manifestations and cytokine profile in mice. In this study, we recruited twenty-eight C57BL/6 mice and divided them into 4 groups: healthy controls, EAE, EAE with calcitriol treatment, and healthy mice with calcitriol treatment...
October 29, 2023: Iranian Journal of Allergy, Asthma, and Immunology