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Iranian Journal of Allergy, Asthma, and Immunology

Mehrdad Farrokhi, Mehrnoosh Dabirzadeh, Nastaran Dastravan, Masoud Etemadifar, Keyvan Ghadimi, Zahra Saadatpour, Ali Rezaei
Multiple sclerosis (MS) is a complex, demyelinating disease of the central nervous system (CNS) with variable phenotypic presentations, while Guillain-Barre Syndrome (GBS) is the prototypic acute inflammatory disorder that affects the peripheral nervous system. Myasthenia gravis (MG) is a T cell dependent and antibody mediated autoimmune disease. Although it has been shown that complement plays a critical role in the pathogenesis of MS, GBS, and MG, the role of mannose-binding lectin (MBL) as a biomarker of immunopathogensis of these diseases and also its association with the severity of them have been poorly investigated...
June 2016: Iranian Journal of Allergy, Asthma, and Immunology
Maryam Keshavarz, Mohammad Hossein Nicknam, Majid Tebyanian, Mohammad Kazem Shahkarami, Maryam Izad
Measles, mumps and rubella are viral infectious diseases that may result in serious complications. Since the production of vaccines, the number of cases of these diseases has been dropped. Nevertheless, these infectious diseases are still one of the major health problems in developing countries. In this study, in order to evaluate the protective responses against measles, mumps and rubella, the level and avidity of virus-specific IgG antibodies were measured in 53 medical students of Tehran University, aged between 20-30 years...
June 2016: Iranian Journal of Allergy, Asthma, and Immunology
Hui Xu, Yan-Xiang Pan, Junfeng Zhang, Yujie Liu, Jian-Hua Mao, Wei Li
Henoch-Schönlein purpura (HSP), a common allergic hemorrhagic disease, occurs frequently in children affecting kidney, joint and skin. While interleukin-8 (IL-8) plays an important role in inflammation, the association between IL-8 gene +781 C/T polymorphism and HSP remains unclear. Interleukin-8, an important chemokine related to the initiation and amplification of acute inflammatory responses, has been reported to be involved in the pathogenesis of some autoimmune and inflammatory diseases. In this study, we aimed to investigate whether IL-8 gene +781 C/T (rs2227306) polymorphism has an influence on susceptibility and clinical manifestations of patients to HSP...
June 2016: Iranian Journal of Allergy, Asthma, and Immunology
Sahar Mortezagholi, Zohreh Babaloo, Parisa Rahimzadeh, Mojgan Ghaedi, Hayedeh Namdari, Shirin Assar, Maryam Azimi Mohamadabadi, Eisa Salehi
Systemic lupus erythematosus (SLE) is a chronic autoimmune disease which results in damage to various organs. Some animal studies have revealed that activation of Toll-like receptors (TLRs) is important in the pathogenesis of SLE. In the present study, the percentage of different immune cell subsets in 35 SLE patients and 38 control subjects was analyzed by flow cytometry. We also assessed the expression of TLR9 in the population of peripheral blood mononuclear cells (PBMCs) including T lymphocytes (CD4+ and CD8+), B lymphocytes (CD19+), NK cells (CD56+) and monocytes (CD14+) in SLE patients and healthy controls...
June 2016: Iranian Journal of Allergy, Asthma, and Immunology
Javad Kiani, Saedeh Khadempar, Mehrdad Hajilooi, Hamzeh Rezaei, Fatemeh Keshavarzi, Ghasem Solgi
Many studies have shown that cytotoxic T lymphocyte antigen-4 (CTLA-4) gene variants are associated with several autoimmune diseases particularly type 1 diabetes. Due to the lack of consistent data for this association with type 2 diabetes (T2D), this study explored the possible influence of CTLA-4 gene polymorphisms at -1722 (T/C), -318 (C/T), and +49 (G/A) positions for susceptibility to T2D in relation with neuropathy. One hundred and eleven unrelated patients with T2D [49 patients with diabetic peripheral neuropathy (DPN) and 62 patients without PDN] and 100 healthy ethnic- and gender-matched controls were included in this study...
June 2016: Iranian Journal of Allergy, Asthma, and Immunology
Soodeh Razeghi Jahromi, Amir Ghaemi, Akram Alizadeh, Fatemeh Sabetghadam, Hedieh Moradi Tabriz, Mansoureh Togha
Several religions recommend periods of fasting. One of the most frequently asked questions of MS patients before the holy month of Ramadan is weather fasting might have an unfavorable effect on their disease course. This debate became more challenging after the publication of experimental studies suggesting that calorie restriction prior to disease induction attenuates disease severity. We conducted this study to assess early and late effects of fasting on the animal model of MS, known as autoimmune encephalomyelitis...
June 2016: Iranian Journal of Allergy, Asthma, and Immunology
Ebrahim Kouchaki, Bentolhoda Otroshi Shahreza, Saiedeh Faraji, Hassan Nikoueinejad, Mojtaba Sehat
Previous studies have demonstrated that vascular endothelial growth factor (VEGF) can trigger angiogenesis as well as inflammation through binding to its membranous receptor-1 on endothelial and inflammatory cells. We aimed to correlate the circulatory number of cells expressing such receptor as well as the serum level of VEGF and the soluble form of its receptor-1 (sVEGFR1) to the severity of multiple sclerosis (MS). This case-control study was done on 102 cases of MS lacking any other inflammatory or pathologic conditions and 75 healthy volunteer subjects...
June 2016: Iranian Journal of Allergy, Asthma, and Immunology
Mozhgan Moghtaderi, Zinatosadat Hejrati, Zahra Dehghani, Faranak Dehghani, Niloofar Kolahi
There has been a great increase in the consumption of various food additives in recent years. The purpose of this study was to identify the incidence of sensitization to food additives by using skin prick test in patients with allergy and to determine the concordance rate between positive skin tests and oral challenge in hypersensitivity to additives. This cross-sectional study included 125 (female 71, male 54) patients aged 2-76 years with allergy and 100 healthy individuals. Skin tests were performed in both patient and control groups with 25 fresh food additives...
June 2016: Iranian Journal of Allergy, Asthma, and Immunology
Mohammad Reza Aslani, Rana Keyhanmanesh, Amir Mehdi Khamaneh, Mohammad Ali Ebrahimi Saadatlou, Mehran Mesgari Abbasi, Mohammad Reza Alipour
Epidemiological and clinical studies indicate a close relationship between obesity and asthma. Here, we determined the impact of diet-induced obesity on the expression levels of IL-1β, IRAK-1 and TRAF-6 mRNA as well as IL-1β protein level and pathological changes in male Wistar rat's lung after sensitization with ovalbumin (OVA). Twenty male Wistar rats divided into four groups, control with normal diet (C+ND), OVA-sensitized with normal diet (S+ND), control with high-fat diet (C+HFD), and OVA-sensitized with high-fat diet (S+HFD)...
June 2016: Iranian Journal of Allergy, Asthma, and Immunology
Mahshid Aryanpur, Esmaeil Mortaz, Mohammad Reza Masjedi, Payam Tabarsi, Johan Garssen, Ian M Adcock, Alireza Mozafarian, Hooman Sharifi
Tuberculosis (TB) and tobacco use are two major alarming global health issues posing immense threats to human populations. Mycobacterium tuberculosis (MTB) by activation of macrophages could induce the sequences of cells activation and releases of inflammatory cytokines such as CXCL-8, Il-12 and TNF-α which in turn induces the immune system network. However no information is available on other activity of cells by MTB and smoking. In the current study we aimed to investigate the serum levels TNF-a, CXCL-8 and phagocytosis capacity in tuberculosis patients with and without smoking...
June 2016: Iranian Journal of Allergy, Asthma, and Immunology
Mohammad Asgharzadeh, Sajjad Ghorghanlu, Jalil Rashedi, Behroz Mahdavi Poor, Fatemeh Khaki-Khatibi, Seyyed Reza Moaddab, Hossein Samadi-Kafil, Mahya Pourostadi
Promoter polymorphism of cytokine genes may lead to inter-individual differences in cytokine levels, therefore, polymorphisms may associate with susceptibility to infectious diseases. In this study, we investigated a possible association between interleukin-10 (IL-10) -1082A⁄G (rs1800896) and interferon (IFN)-gamma +874T/A (rs2430561) promoter polymorphisms and tuberculosis (TB) in the Azeri population of Iran. IL-10 -1082G/A and IFN-gamma +874T/A single nucleotide polymorphisms (SNPs) were genotyped by amplification refractory mutation system (ARMS)-PCR in 200 healthy controls and 124 tuberculosis patients...
June 2016: Iranian Journal of Allergy, Asthma, and Immunology
Beuy Joob, Viroj Wiwanitkit
No Abstract.
April 2016: Iranian Journal of Allergy, Asthma, and Immunology
Raheleh Shokouhi Shoormasti, Mohammad Reza Fazlollahi, Saeedeh Barzegar, Pegah Teymourpour, Zahra Yazdanyar, Zahra Lebaschi, Maryam Nourizadeh, Behnaz Tazesh, Masoud Movahedi, Homa Kashani, Zahra Pourpak, Mostafa Moin
Cow's milk allergy (CMA) is an immunological response to cow's milk proteins such as casein, α-lactalbumin and β lactoglobulin. The aim of this study was to determine the most common cow's milk allergenic proteins in patients with CMA and identify the most effective proteins in different allergic symptoms. Eighty seven patients (≤18 years) with allergy to cow's milk from 2006 to 2013 entered this study. They had a positive history of allergic reactions to cow's milk and a positive specific IgE test to whole cow's milk...
April 2016: Iranian Journal of Allergy, Asthma, and Immunology
Zailatul Hani Mohamad Yadzir, Faizal Bakhtiar, Rosmilah Misnan, Noormalin Abdullah, Brenda Leecyous, Shahnaz Murad
Allergy diagnosis needs to be improved in polysensitized patients due to the existence of possible confounding factors in this type of patients. Component resolved diagnosis (CRD) is a new concept in the investigation of polysensitized patients. The aim of this study was to evaluate if the utilization of ImmunoCAP ISAC improve the diagnosis of the polysensitized allergic rhinitis patients. Skin prick test (SPT) to 58 crude allergen extracts and CRD (ImmunoCAP ISAC) were carried out for 5 polysensitized allergic rhinitis patients...
April 2016: Iranian Journal of Allergy, Asthma, and Immunology
Ameneh Ghaffarinia, Shahram Parvaneh, Cyrus Jalili, Farhad Riazi-Rad, Somayeh Yaslianifard, Nafiseh Pakravan
Multiple sclerosis (MS) and its animal model, experimental autoimmune encephalomyelitis (EAE), are inflammatory autoimmune diseases of the central nervous system. Chymotrypsin is a serine protease with immunomodulatory effect in the peripheral organs. We previously demonstrated the immunomodulatory effect of chymotrypsin in ameliorating the EAE in female Lewis rats. However, there are sex-based differences in the immune system, drug activity, and CNS structure and composition. In addition, female gender is a better prognostic indicator of MS and males are more severely affected by EAE than females...
April 2016: Iranian Journal of Allergy, Asthma, and Immunology
SungChul Seo, Won Suck Yoon, Yunjung Cho, Sang Hee Park, Ji Tae Choung, Young Yoo
The prevalence of atopic dermatitis (AD) and obesity have been increasing considerably in Korean school-children. AD is a chronic pruritic recurrent inflammatory skin disorder. Leptin is secreted by adipocytes which has been suggested to be immunologically active; however, their role in AD has not yet been well understood. A total of 227 subjects out of 2,109 elementary school children were defined as having AD based on the ISAAC questionnaire survey. Ninety subjects with AD, aged between 6 and 12 years, completed scoring of severity of AD (SCORAD), skin prick testing, blood tests for total IgE, eosinophil counts, eosinophil cationic protein (ECP) and lipid profiles...
April 2016: Iranian Journal of Allergy, Asthma, and Immunology
Mozhgan Moghtaderi, Shirin Farjadian, Mohammad Fereidouni, Mahboubeh Nasiri, Arsalan Nejat
Exposure to indoor allergens plays an important role in the etiology of asthma. This study was designed to quantify indoor allergens from homes of families that had at least one case of childhood asthma at home in a southwestern city of Iran. The relationship between the indoor allergen levels and home characteristics was also investigated. Dust samples were collected from the bedrooms and the kitchens of 35 homes where children with persistent asthma were living. The levels of indoor allergens were measured by enzyme linked immunosorbent assay (ELISA)...
April 2016: Iranian Journal of Allergy, Asthma, and Immunology
Fatemeh Dousti, Mohammad-Ali Assarehzadegan, Payam Morakabati, Gholam Reza Khosravi, Bahareh Akbari
Pollen from mesquite (Prosopis juliflora) is one of the important causes of immediate hypersensitivity reactions in the arid and semi-arid regions of the world. The aim of present study is to produce and purify the recombinant form of allergenic Ole e 1-like protein from the pollen of this allergenic tree. Immunological and cross-inhibition assays were performed for the evaluation of IgE-binding capacity of purified recombinant protein. For molecular cloning, the coding sequence of the mesquite Ole e 1-like protein was inserted into pTZ57R/T vector and expressed in Escherichia coli using the vector pET-21b(+)...
April 2016: Iranian Journal of Allergy, Asthma, and Immunology
Tomic-Spiric Vesna, Dizdarevic Denisa, Jankovic Slavenka, Burazer Lidija, Barac Aleksandra, Bolpacic Jasna, Djuric Vojislav, Peric-Popadic Aleksandra, Aleksic Aleksandra, Bogic Mirjana
Sublingual allergen immunotherapy (SLIT) is considered to be safer and more convenient than subcutaneus immunotherapy. SLIT trials with house dust mites involving patients with allergic rhinitis (AR) and asthma reported discordant results. The aim of the study was to investigate the clinical efficacy and safety of SLIT with Dermatophagoides pteronyssinus ( extract produced in Serbia and patient's satisfaction through open-label trial. Adult patients with allergic rhinitis were randomized into two groups: one received drugs and SLIT, while other received only drugs...
April 2016: Iranian Journal of Allergy, Asthma, and Immunology
Sait Karaman, Demet Can, Semiha Bahçeci Erdem, Hikmet Tekin Nacaroğlu, Canan Şule Karkıner, İlker Günay
Few biomarkers that can predict the clinical response to allergen immunotherapy (AIT) have been identified. The aim of the present study was to investigate parameters that could be used "in predicting the clinical response to AIT" in children with asthma caused by house dust mites. We evaluated 107 children with mild persistent asthma who were sensitised only to mite aeroallergens. The study group included 47 patients who underwent a 4-to-5-year course of subcutaneous immunotherapy with standardised mite allergenic extract...
April 2016: Iranian Journal of Allergy, Asthma, and Immunology
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