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Orthodontics & Craniofacial Research

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https://www.readbyqxmd.com/read/28737274/longitudinal-dental-maturation-of-children-with-complete-unilateral-cleft-lip-and-palate-a-case-control-cohort-study
#1
E L Y Tan, M C Kuek, H C Wong, M Yow
OBJECTIVES: Many reports suggest that children with cleft lip and palate (CLP) have delayed dental development and asymmetrical timing of tooth-pair formation. We aimed to investigate the dental maturation of permanent teeth in children with complete unilateral CLP (UCLP) and compare the findings with non-CLP children. SETTING AND SAMPLE POPULATION: This case-control study used 115 radiographs of children with complete UCLP and controls (non-CLP children matched on age, gender and ethnicity) from a hospital-based dental clinic in Singapore...
July 24, 2017: Orthodontics & Craniofacial Research
https://www.readbyqxmd.com/read/28670875/validity-of-the-american-board-of-orthodontics-discrepancy-index-and-the-peer-assessment-rating-index-for-comprehensive-evaluation-of-malocclusion-severity
#2
S Liu, H Oh, D W Chambers, S Baumrind, T Xu
OBJECTIVES: To assess the validity of the American Board of Orthodontics Discrepancy Index (ABO-DI) and Peer Assessment Rating (PAR) Index in evaluating malocclusion severity in Chinese orthodontic patients. SETTING AND SAMPLE POPULATION: A stratified random sample of 120 orthodontic patients based on Angle classification was collected from six university orthodontic centres. MATERIAL AND METHODS: Sixty-nine orthodontists rated malocclusion severity on a five-point scale by assessing a full set of pre-treatment records for each case and listed reasons for their decision...
July 3, 2017: Orthodontics & Craniofacial Research
https://www.readbyqxmd.com/read/28660731/zygomaticomaxillary-suture-maturation-part-ii-the-influence-of-sutural-maturation-on-the-response-to-maxillary-protraction
#3
F Angelieri, A C Ruellas, M S Yatabe, L H S Cevidanes, L Franchi, C Toyama-Hino, H J De Clerck, T Nguyen, J A McNamara
OBJECTIVE: To evaluate the influence of the maturational stages of zygomaticomaxillary sutures (ZMS) on the response to maxillary protraction. SUBJECTS AND METHODS: A total of 40 Class III patients were treated retrospectively with either a combination of rapid maxillary expansion and facial mask (RME/FM) or bone-anchored maxillary protraction (BAMP). The RME/FM group consisted of 18 patients (mean age 8.3 years), while the BAMP group was comprised of 22 patients (mean age 11...
June 29, 2017: Orthodontics & Craniofacial Research
https://www.readbyqxmd.com/read/28727319/novel-evaluation-and-treatment-techniques-for-white-spot-lesions-an-in-vitro-study
#4
T A Bakhsh, A S Bakry, M M Mandurah, M A Abbassy
OBJECTIVE: White spot lesions (WSLs) are commonly seen during and after orthodontic treatment. Therefore, the objective of this in vitro study was to assess the effect of 45S5-bioglass in remineralizing WSLs using cross-polarization optical coherence tomography (CP-OCT) and confirm the findings by micro-hardness test. METHODS: Ceramic orthodontic brackets were bonded to the buccal surface of 45 human premolars with Transbond XT primer followed by Transbond PLUS according to the manufacturer's instructions...
August 2017: Orthodontics & Craniofacial Research
https://www.readbyqxmd.com/read/28727318/appropriate-cyclic-tensile-strain-promotes-biological-changes-of-cranial-base-synchondrosis-chondrocytes
#5
F Chu, Q Feng, Z Hu, G Shen
OBJECTIVES: This study was designed to clarify biological changes of cranial base synchondrosis chondrocytes (CBSCs) upon cyclic tensile strain (CTS) loading which simulated orthopaedic mechanical protraction on cranial base synchondroses (CBS). MATERIAL AND METHODS: A two-step digestion method was used to isolate CBSCs obtained from 1-week-old Sprague Dawley rats. Immunohistochemical staining of type II collagen and Sox9 was conducted to identify chondrocytes. A CTS of 1 Hz and 10% elongation was applied to the second passage of CBSCs by FX-5000™ Tension System for 24 hours...
August 2017: Orthodontics & Craniofacial Research
https://www.readbyqxmd.com/read/28670780/lithium-enhances-alveolar-bone-formation-during-orthodontic-retention-in-rats
#6
J Pan, S He, X Yin, Y Li, C Zhou, S Zou
OBJECTIVE: To investigate the effect of lithium on alveolar bone formation during orthodontic retention in rats. MATERIALS AND METHODS: After 2 weeks of orthodontic tooth movement (OTM), 42 8-week-old male Wistar rats were randomly divided into two orthodontic retention groups: one without (control) and the other with LiCl treatment (LiCl group). Samples were collected on days 0, 3, 7 and 14 during the retention period. We evaluated the bone volume/total volume (BV/TV) ratio and new bone formation in the region of interests (ie, the root, the periodontal ligament and the adjacent alveolar bone around the distal buccal surface of the distal root of the maxillary first molar)...
August 2017: Orthodontics & Craniofacial Research
https://www.readbyqxmd.com/read/28653350/zoledronic-acid-and-alendronate-sodium-and-the-implications-in-orthodontic-movement
#7
J S Franzoni, F M P Soares, E Zaniboni, M Vedovello Filho, M P Santamaria, G M T Dos Santos, M A M Esquisatto, M Felonato, F A S Mendonca, C M Franzini, M Santamaria
OBJECTIVE: To evaluate orthodontic tooth movement (OTM) in rats treated with two types of bisphosphonates (BPs), alendronate sodium (A) and zoledronic acid (Z). DESIGN: In all, 15 male Wistar rats were randomly divided into three groups. Group OTM+A: orthodontic tooth movement and subcutaneous administration of alendronate sodium (2.5 mg/kg); Group OTM+Z: orthodontic tooth movement and subcutaneous administration of zoledronic acid (0.02 mg/kg), and Group OTM: orthodontic tooth movement and subcutaneous injection of saline...
August 2017: Orthodontics & Craniofacial Research
https://www.readbyqxmd.com/read/28547915/efficiency-effectiveness-and-treatment-stability-of-clear-aligners-a-systematic-review-and-meta-analysis
#8
M Zheng, R Liu, Z Ni, Z Yu
OBJECTIVES: The objective of this study was to perform a systematic review of the orthodontic literature with regard to efficiency, effectiveness and stability of treatment outcome with clear aligners compared with treatment with conventional brackets. METHODS: An electronic search without time or language restrictions was undertaken in October 2014 in the following electronic databases: Google Scholar, the Cochrane Oral Health Group's Trials Register, Scopus, CENTRAL, MEDLINE via OVID, EMBASE via OVID and Web of Science...
August 2017: Orthodontics & Craniofacial Research
https://www.readbyqxmd.com/read/28661083/centre-level-variation-in-behaviour-and-the-predictors-of-behaviour-in-5-year-old-children-with-non-syndromic-unilateral-cleft-lip-the-cleft-care-uk-study-part-5
#9
A Waylen, O Mahmoud, A K Wills, D Sell, J R Sandy, A R Ness
OBJECTIVES: The aims of this study were to describe child behavioural and psychosocial outcomes associated with appearance and speech in the Cleft Care UK (CCUK) study. We also wanted to explore centre-level variation in child outcomes and investigate individual predictors of such outcomes. SETTING AND SAMPLE POPULATION: Two hundred and sixty-eight five-year-old children with non-syndromic unilateral cleft lip and palate (UCLP) recruited to CCUK. MATERIALS AND METHODS: Parents completed the Strengths and Difficulties questionnaire (SDQ) and reported their own perceptions of the child's self-confidence...
June 2017: Orthodontics & Craniofacial Research
https://www.readbyqxmd.com/read/28661082/centre-level-variation-of-treatment-and-outcome-in-5-year-old-children-with-non-syndromic-unilateral-cleft-lip-and-palate-the-cleft-care-uk-study-part-1-methodology-and%C3%A2-results-for-dento-facial-outcomes
#10
A K Wills, O Mahmoud, A Hall, D Sell, J Smallridge, L Southby, S Toms, A Waylen, Y Wren, A R Ness, J R Sandy
OBJECTIVES: Outline methods used to describe centre-level variation in treatment and outcome in children in the Cleft Care UK (CCUK) study. Report centre-level variation in dento-facial outcomes. SETTING AND SAMPLE POPULATION: Two hundred and sixty-eight five-year-old British children with non-syndromic unilateral cleft lip and palate (UCLP). MATERIALS AND METHODS: Between January 2011 and December 2012, data were collected on a comprehensive range of outcomes...
June 2017: Orthodontics & Craniofacial Research
https://www.readbyqxmd.com/read/28661081/centre-level-variation-in-treatment-and-outcomes-and-predictors-of-outcomes-in-5-year-old-children-with-non-syndromic-unilateral-cleft-lip-treated-within-a-centralized-service-the-cleft-care-uk-study-part-6-summary-and-implications
#11
A R Ness, A K Wills, O Mahmoud, A Hall, D Sell, J Smallridge, L Southby, D Stokes, S Toms, A Waylen, Y Wren, J R Sandy
OBJECTIVES: To summarize and discuss centre-level variation across a range of treatment and outcome measures and examine individual and ecological determinants of outcome in children in Cleft Care UK (CCUK). SETTING AND SAMPLE POPULATION: Two hundred and sixty-eight 5-year-old British children with non-syndromic unilateral cleft lip and palate (UCLP) recruited to CCUK and treated within a centralized service. MATERIALS AND METHODS: Children had a range of treatment and outcome measures collected at a 5-year audit clinic...
June 2017: Orthodontics & Craniofacial Research
https://www.readbyqxmd.com/read/28661080/centre-level-variation-in-outcomes-and-treatment-for-otitis-media-with-effusion-and-hearing-loss-and-the-association-of-hearing-loss-with-developmental-outcomes-at-ages-5-and-7%C3%A2-years-in-children-with-non-syndromic-unilateral-cleft-lip-and-palate-the-cleft
#12
A Hall, A K Wills, O Mahmoud, D Sell, A Waylen, S Grewal, J R Sandy, A R Ness
OBJECTIVES: To explore centre-level variation in otitis media with effusion (OME), hearing loss and treatments in children in Cleft Care UK (CCUK) and to examine the association between OME, hearing loss and developmental outcomes at 5 and 7 years. SETTING AND SAMPLE POPULATION: Two hundred and sixty-eight 5-year-old British children with non-syndromic unilateral cleft lip and palate (UCLP) recruited to CCUK. MATERIALS AND METHODS: Children had air and bone conduction audiometry at age 5...
June 2017: Orthodontics & Craniofacial Research
https://www.readbyqxmd.com/read/28661079/centre-level-variation-in-dental-treatment-and-oral-health-and-individual-and-area-level-predictors-of-oral-health-in-5-year-old-children-with-non-syndromic-unilateral-cleft-lip-and-palate-the-cleft-care-uk-study-part-3
#13
J Smallridge, A K Wills, O Mahmoud, A Chong, V Clark, M Collard, J R Sandy, A R Ness
OBJECTIVES: To explore centre-level variation in fluoride treatment and oral health outcomes and to examine the association of individual- and area-level risk factors with dental decay in Cleft Care UK (CCUK). SETTING: Two hundred and sixty-eight 5-year-old British children with non-syndromic unilateral cleft lip and palate (UCLP). MATERIALS AND METHODS: Data on caries and developmental defects of enamel (DDE) were collected. The child's history of fluoride ingestion and postcode was used to assess exposure to fluoridated water...
June 2017: Orthodontics & Craniofacial Research
https://www.readbyqxmd.com/read/28661078/centre-level-variation-in-speech-outcome-and-interventions-and-factors-associated-with-poor-speech-outcomes-in-5-year-old-children-with-non-syndromic-unilateral-cleft-lip-and%C3%A2-palate-the-cleft-care-uk-study-part-4
#14
D Sell, L Southby, Y Wren, A K Wills, A Hall, O Mahmoud, A Waylen, J R Sandy, A R Ness
OBJECTIVES: To investigate centre-level variation in speech intervention and outcome and factors associated with a speech disorder in children in Cleft Care UK (CCUK). SETTING AND SAMPLE POPULATION: Two hundred and sixty-eight 5-year-old British children with non-syndromic unilateral cleft lip and palate recruited to CCUK. MATERIALS AND METHODS: Centre-based therapists undertook audio-video recordings. Perceptual analysis was undertaken using the CAPS-A tool...
June 2017: Orthodontics & Craniofacial Research
https://www.readbyqxmd.com/read/28643933/oncologic-doses-of-zoledronic-acid-induce-site-specific-suppression-of-bone-modelling-in-rice-rats
#15
C R Exposto, U Oz, J S Callard, M J Allen, H Khurana, A D' Atri, X Mo, S A Fernandez, D N Tatakis, K Edmonds, P M Westgate, S S Huja
OBJECTIVES: To examine the effect of zoledronic acid (ZOL) on cortical bone modelling and healing of extraction sockets in the jaw bones of a rodent model. We hypothesized ZOL suppresses both the bone formation in the modelling mode in the jaw bones and alters the extraction site healing. MATERIAL & METHODS: Rice rats were administered saline solution and two dose regimens of ZOL: 0.1 mg/kg, twice a week, for 4 weeks (n=17, saline=8 & ZOL=9) and a higher dose of 0...
June 2017: Orthodontics & Craniofacial Research
https://www.readbyqxmd.com/read/28643932/gene-environment-interactions-in-craniosynostosis-a-brief-review
#16
REVIEW
E L Durham, R N Howie, J J Cray
It is suggested that craniosynostosis is caused by a heterogeneous set of effects including gene mutations, teratogenic exposure during critical periods of development and gene/environment interactions. Distinguishing between sufficient, additive and interactive effects is important to the study of gene/environment interactions and allows for segregation of environmental exposures effecting susceptible populations. Through the identification of sufficient and interactive effects, efforts in prevention of craniosynostosis may be successful...
June 2017: Orthodontics & Craniofacial Research
https://www.readbyqxmd.com/read/28643931/clinical-effectiveness-of-late-maxillary-protraction-in-cleft-lip-and-palate-a-methods-paper
#17
M K Lee, C Lane, F Azeredo, M Landsberger, H Kapadia, B Sheller, S L Yen
OBJECTIVES: A prospective parallel cohort trial was conducted to compare outcomes of patients treated with maxillary protraction vs LeFort 1 maxillary advancement surgery. SETTING AND SAMPLE POPULATION: The primary site for the clinical trial is Children's Hospital Los Angeles; the satellite test site is Seattle Children's Hospital. All patients have isolated cleft lip and palate and a skeletal Class III malocclusion. MATERIAL AND METHODS: A total of 50 patients, ages 11-14, will be recruited for the maxillary protraction cohort...
June 2017: Orthodontics & Craniofacial Research
https://www.readbyqxmd.com/read/28643930/moving-towards-precision-orthodontics-an-evolving-paradigm-shift-in-the-planning-and-delivery-of-customized-orthodontic-therapy
#18
REVIEW
A H Jheon, S Oberoi, R C Solem, S Kapila
Advances in precision medicine portend similar progress in orthodontics and will be increasingly harnessed to achieve customized treatment approaches and enhance treatment efficiencies. Our goal is to provide a background on emerging advances in computer technologies and biomedicine and highlight their current and likely future applications to precision orthodontics. A review of orthodontically relevant technologies and advances in pertinent biological research was undertaken. Innovations in computer hardware and software, and 3D imaging technologies offer the ability for customized treatment and biomechanical planning that will be more fully realized within the next few decades...
June 2017: Orthodontics & Craniofacial Research
https://www.readbyqxmd.com/read/28643929/in-silico-and-functional-evaluation-of-pth1r-mutations-found-in-patients-with-primary-failure-of-eruption-pfe
#19
H M Hendricks, S Bencharit, W Seaman, S A Frazier-Bowers
OBJECTIVES: The genetic basis of PFE (OMIM ID: 125350) was interrogated using molecular functional studies. PFE is a disorder that results in a poor prognosis in the eruption of teeth and by extension, in treatment with a continuous archwire. We tested the hypothesis that PTH1R mutations result in loss of function due to altered protein structure to determine (i) the fate of a functional PTH1R mutation and (ii) the resulting PTH1R protein structure of each functional mutation. METHODS: We used immunofluorescence assay of COS7 cells that were transfected with either the WT or 1092delG PTH1R mutation sequence to compare the fate of the expressed protein...
June 2017: Orthodontics & Craniofacial Research
https://www.readbyqxmd.com/read/28643928/calvarial-bone-development-and-suture-closure-in-dicer-deficient-mice
#20
P Atsawasuwan, M Ouibaidin, B Dalal, H Khan, A Mohammed
OBJECTIVE: To evaluate whether lack of Dicer during calvaria development would lead to dysmorphology of calvaria and suture closure in mice. MATERIALS AND METHODS: A conditional Dicer deficient under Osx promoter mouse was employed in this study. The 4- and 10-week-old conditional Dicer-deficient mice control littermates and Osx-cre transgenic mice were studied for calvarial bone morphology and suture closure. Dry skull, microcomputed tomography (μCT), histological and gene expression studies were investigated to evaluate the effect of Dicer deficiency on calvarial bone morphology and their related genes during calvaria development...
June 2017: Orthodontics & Craniofacial Research
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