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Hormones: International Journal of Endocrinology and Metabolism

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https://www.readbyqxmd.com/read/29518764/sarcopenia-from-definition-to-treatment
#1
Yannis Dionyssiotis, Athina Kapsokoulou, Eleni Samlidi, Antonios G Angoules, Jannis Papathanasiou, Efstathios Chronopoulos, Ifigenia Kostoglou-Athanassiou, Georgios Trovas
No abstract text is available yet for this article.
October 2017: Hormones: International Journal of Endocrinology and Metabolism
https://www.readbyqxmd.com/read/29518763/medullary-thyroid-cancer-leukemia-mesothelioma-and-meningioma-associated-with-germline-apc-and-rasal1-variants-a-new-syndrome
#2
Anna Angelousi, Nikolaos Settas, Fabio R Faucz, Charalampos Lyssikatos, Martha Quezado, Narjes Nasiri-Ansari, Constantine A Stratakis, Eva Kassi
Medullary thyroid carcinoma (MTC) is a neuroendocrine tumor hereditary in 35% of cases. The most common syndromic form is in the context of the multiple endocrine neoplasia type 2 (MEN 2) syndromes in association with other tumors and due to germline RET mutations. We describe a 57-year-old female patient diagnosed with sporadic MTC. The patient had a history of other neoplasias, such as acute myeloid leukemia, for which she had received chemotherapy, and two other solid tumors, peritoneal mesothelioma and meningioma...
October 2017: Hormones: International Journal of Endocrinology and Metabolism
https://www.readbyqxmd.com/read/29518762/diagnostic-value-of-the-water-deprivation-test-in-the-polyuria-polydipsia-syndrome
#3
Penelope Trimpou, Daniel S Olsson, Olof Ehn, Oskar Ragnarsson
OBJECTIVE: Diabetes insipidus (DI) and primary polydipsia (PP) are characterised by polyuria and polydipsia. It is crucial to differentiate between these two disorders since the treatment is different. The aim of this study was to evaluate the diagnostic value of the short and an extended variant of the water deprivation test (WDT) and of measuring urinary vasopressin (AVP) in patients with polyuria and polydipsia. DESIGN: A retrospective, single-centre study based on WDTs performed between 2004 and 2014 including 104 consecutive patients with the polyuria-polydipsia syndrome...
October 2017: Hormones: International Journal of Endocrinology and Metabolism
https://www.readbyqxmd.com/read/29518761/hormonal-responses-following-eccentric-exercise-in-humans
#4
Anastassios Philippou, Maria Maridaki, Roxane Tenta, Michael Koutsilieris
OBJECTIVE: Mechanically overloaded muscle and its subsequent damage are strong stimuli for eliciting acute hormonal changes, while the muscle adaptation which occurs following exercise-induced muscle damage may involve complex hormonal responses before the completion of muscle regeneration. The purpose of this study was to investigate systemic responses of various hormones, as well as secreted proteins that are exercise-regulated and associated with muscle adaptation, for several days after eccentric exercise-induced muscle damage in humans...
October 2017: Hormones: International Journal of Endocrinology and Metabolism
https://www.readbyqxmd.com/read/29518760/baseline-glucose-homeostasis-predicts-the-new-onset-of-diabetes-during-statin-therapy-a-retrospective-study-in-real-life
#5
Maria Chantal Ponziani, Ioannis Karamouzis, Chiara Mele, Luisa Chasseur, Marco Zavattaro, Marina Caputo, Maria Teresa Samà, Arianna Busti, Loredana Pagano, Luigi Castello, Paolo Marzullo, Gianluca Aimaretti, Flavia Prodam
OBJECTIVE: We evaluated the risk of altered glucose levels and new-onset diabetes (NOD) associated with statins according to glucose levels at baseline in a population treated for dyslipidemia on primary prevention for >5 years. DESIGN: The retrospective study included 308 subjects (265 on statins and 43 controls on diet) with a follow-up of 5-15 years. The cohort was classified according to glucose tolerance at both baseline and follow-up. RESULTS: The cumulative incidence of NOD was 13...
October 2017: Hormones: International Journal of Endocrinology and Metabolism
https://www.readbyqxmd.com/read/29518759/surgery-for-pheochromocytoma-a-20-year-experience-of-a-single-institution
#6
Chrysanthi Aggeli, Alexander M Nixon, Christos Parianos, Georgios Vletsis, Labrini Papanastasiou, Theodora Kounadi, Georgrios Piaditis, Georgios N Zografos
OBJECTIVE: Resection of pheochromocytomas is a challenging procedure due to hemodynamic lability. Our aim was to evaluate surgical outcomes in 67 patients with pheochromocytoma and to validate the role of laparoscopic surgery in the treatment of these tumors. DESIGN: This study is a retrospective review. A total of 68 procedures for pheochromocytoma were performed between June 1997 and February 2017. All patients were investigated and operated on using an established departmental protocol...
October 2017: Hormones: International Journal of Endocrinology and Metabolism
https://www.readbyqxmd.com/read/29518758/differentiated-thyroid-cancer-in-childhood-a-literature-update
#7
REVIEW
Olga Karapanou, Marinella Tzanela, Tzanela Vlassopoulou, Christina Kanaka-Gantenbein
Differentiated thyroid cancer in childhood is rare. Apart from family history, radiation exposure is a major risk factor. Although its clinical course is quite aggressive with higher rates of lymph node and pulmonary metastases as compared to adults, the final outcome tends to be favorable with mortality rates less than 2%. We herein review the clinical picture, genetic background response to treatment and recurrence rates of differentiated thyroid cancer in children and young adolescents are thoroughly reviewed and the main differences with adult differentiated thyroid cancer are highlighted...
October 2017: Hormones: International Journal of Endocrinology and Metabolism
https://www.readbyqxmd.com/read/29518757/prevalence-pathogenesis-and-management-of-prediabetes-and-type-2-diabetes-mellitus-in-patients-with-polycystic-ovary-syndrome
#8
REVIEW
Sofia Lazaridou, Konstantinos Dinas, Konstantinos Tziomalos
Polycystic ovary syndrome (PCOS) is the most common endocrinopathy in women of reproductive age. PCOS is not only the leading cause of anovulatory infertility but is also associated with an array of metabolic disorders, among which impaired glucose metabolism has been a topic of intense research. The aim of the present narrative review is to summarize the findings of the studies that have evaluated the prevalence and incidence of prediabetes and type 2 diabetes mellitus (T2DM) in patients with PCOS, to analyze the factors underpinning the association between T2DM and PCOS and to discuss the current strategies for screening and management of impaired glucose metabolism in this population...
October 2017: Hormones: International Journal of Endocrinology and Metabolism
https://www.readbyqxmd.com/read/29518756/detection-rate-of-somatostatin-receptor-pet-in-patients-with-recurrent-medullary-thyroid-carcinoma-a-systematic-review-and-a-meta-analysis
#9
REVIEW
Giorgio Treglia, Adriana Tamburello, Luca Giovanella
PURPOSE: Several articles have demonstrated the high diagnostic performance of somatostatin receptor positron emission tomography (PET) in patients with neuroendocrine tumours (NETs). On the other hand, only a few studies have evaluated the detection rate (DR) of this imaging method in recurrent medullary thyroid carcinoma (MTC). We aimed to perform a systematic review and a meta-analysis of the DR of somatostatin receptor PET or PET/CT in patients with recurrent MTC to add evidence-based data to this setting...
October 2017: Hormones: International Journal of Endocrinology and Metabolism
https://www.readbyqxmd.com/read/29518755/diabetic-nephropathy-is-it-always-there-assumptions-weaknesses-and-pitfalls-in-the-diagnosis
#10
REVIEW
Kyriakos Ioannou
Diabetic nephropathy is defined as a microvascular complication of the kidneys induced by diabetes mellitus and is characterized by albuminuria and progressive loss of kidney function. However, neither albuminuria nor glomerular filtration rate decline are diabetic nephropathy-specific markers, thus the diagnosis of diabetic nephropathy greatly depends on assumptions. Several factors should be taken into account when urinary albumin levels are assessed before establishing the diagnosis of diabetic nephropathy, while newer more specific markers for diabetic nephropathy are urgently needed...
October 2017: Hormones: International Journal of Endocrinology and Metabolism
https://www.readbyqxmd.com/read/29518754/endocrine-sequelae-of-immune-checkpoint-inhibitors
#11
REVIEW
Georgia Ntali, Eva Kassi, Maria Alevizaki
Cancer immunotherapy has introduced a novel class of drugs known as immune checkpoint inhibitors (ICIs). They enhance antitumour immunity by blocking negative regulators (checkpoints) of T cell function that exist on both immune and tumour cells. ICIs targeting CTLA-4 and PD-1/PDL-1 have dramatically changed the outcome of patients with several advanced-stage malignancies but they may lead to a variety of inflammatory toxicities and autoimmune consequences. The main endocrine immune-related adverse events (IRAEs) include hypophysitis, primary thyroid dysfunction, adrenalitis and type 1 diabetes mellitus...
October 2017: Hormones: International Journal of Endocrinology and Metabolism
https://www.readbyqxmd.com/read/29278523/menophila-a-poetic-description-of-genital-ambiguity-in-hellenistic-literature
#12
Anastasia K Armeni, Danai Georgopoulou, Georgios K Markantes, Konstantina Barouti, Leonidas Liarakos, Vasiliki Vasileiou, Neoklis A Georgopoulos
No abstract text is available yet for this article.
July 2017: Hormones: International Journal of Endocrinology and Metabolism
https://www.readbyqxmd.com/read/29278522/a-case-of-idiopathic-granulomatous-hypophysitis
#13
Nilufer Ozdemir Kutbay, Mustafa Berker, Figen Soylemezoglu, Hatice Ozisik, Banu Sarer Yurekli
No abstract text is available yet for this article.
July 2017: Hormones: International Journal of Endocrinology and Metabolism
https://www.readbyqxmd.com/read/29278521/the-pineal-gland-and-its-earliest-physiological-description
#14
Konstantinos Laios
No abstract text is available yet for this article.
July 2017: Hormones: International Journal of Endocrinology and Metabolism
https://www.readbyqxmd.com/read/29278520/malignant-struma-ovarii-harboring-a-unique-nras-mutation-case-report-and-review-of-the-literature
#15
Carlo Gobitti, Alessandro Sindoni, Chiara Bampo, Tanja Baresic, Giorgio Giorda, Lara Alessandrini, Vincenzo Canzonieri, Giovanni Franchin, Eugenio Borsatti
Struma ovarii (SO), a rare tumor containing at least 50% of thyroid tissue, represents approximately 5% of all ovarian teratomas; its malignant transformation rate is reported to occur in up to 10% of cases and metastases occur in about 5-6% of them. We describe a 36-year old woman who underwent laparoscopic left annessectomy two years earlier because of an ovarian cyst. Follow-up imaging revealed a right adnexal mass, ascitis and peritoneal nodes that were diagnosed as comprising a malignant SO with peritoneal secondary localizations at histopathology performed after intervention...
July 2017: Hormones: International Journal of Endocrinology and Metabolism
https://www.readbyqxmd.com/read/29278519/gnrh-dependent-precocious-puberty-manifested-at-the-age-of-14-months-in-a-girl-with-47-xxx-karyotype
#16
Nicos Skordis, Eleana Ferrari, Aria Antoniadou, Leonidas A Phylactou, Pavlos Fanis, Vassos Neocleous
This case report describes a 47,XXX girl who presented very early, at the age of 14 months, with signs of sexual precocity (breast and pubic hair development, menarche) and was finally diagnosed with GnRH dependent precocious puberty with no evidence of underlying central nervous system pathology. Molecular testing did not identify any genetic defect in any of the genes tested (KISS1, KISS1R, DLK1 and the intronless MKRN3). Though previous studies have shown a link between karyotype 47,XXX and precocious puberty, this is the youngest patient reported so far...
July 2017: Hormones: International Journal of Endocrinology and Metabolism
https://www.readbyqxmd.com/read/29278518/identification-of-an-ar-mutation-in-klinefelter-syndrome-during-evaluation-for-penoscrotal-hypospadias
#17
Sezer Acar, Hale Tuhan, Elçin Bora, Korcan Demir, Hüseyin Onay, Derya Erçal, Ece Böber, Ayhan Abacı
Genital anomalies, ranging from female genitalia to milder degrees of undervirilization, are rarely reported in Klinefelter syndrome, in which a male is classically expected to be born with male external genitalia. Though androgen insensitivity syndrome (AIS) is one of the possible pathogenic mechanisms also in Klinefelter syndrome with genital anomalies, to date the AR gene has not been analyzed in any of the published cases of Klinefelter syndrome of the milder phenotype, except for those patients presenting with a severe phenotype, such as female external genitalia...
July 2017: Hormones: International Journal of Endocrinology and Metabolism
https://www.readbyqxmd.com/read/29278517/an-insight-into-familial-hypercholesterolemia-in-greece-rationale-and-design-of-the-hellenic-familial-hypercholesterolemia-registry-hellas-fh
#18
Christos V Rizos, Vasilios Athyros, Eleni Bilianou, George Chrousos, Anastasia Garoufi, Genovefa Kolovou, Vasilios Kotsis, Loukianos Rallidis, Emmanouel Skalidis, Ioannis Skoumas, Konstantinos Tziomalos, Evangelos N Liberopoulos
Familial hypercholesterolemia (FH) is the most common metabolic genetic disorder. It is estimated that around 13 million people worldwide have FH. At the same time, only 25% of FH patients have been diagnosed. Moreover, these patients are often undertreated. The true prevalence of FH in Greece is unknown, but it is estimated that there are at least 40,000 FH patients nationwide pointing to a prevalence of 1:250. Patients with FH are at a high risk for cardiovascular events and death at an early age. Therefore, prompt detection of these patients is of pivotal importance in order to implement appropriate preventive measures at a young age...
July 2017: Hormones: International Journal of Endocrinology and Metabolism
https://www.readbyqxmd.com/read/29278516/serum-fetuin-a-levels-are-associated-with-serum-triglycerides-before-and-6-months-after-bariatric-surgery
#19
Christos G Verras, Georgios A Christou, Yannis V Simos, George D Ayiomamitis, Andreas J Melidonis, Dimitrios N Kiortsis
OBJECTIVE: The elucidation of the changes of fetuin-A in the context of bariatric surgery. DESIGN: Twenty obese patients (8 males, 12 females; body mass index = 42.5±3.4 kg/m2) were studied at baseline and 6 months after bariatric surgery. RESULTS: Serum fetuin-A levels did not differ with regard to the presence of each individual component of the Metabolic Syndrome (MetS) at baseline, except for hypertriglyceridaemia [increased serum fetuin-A levels (p=0...
July 2017: Hormones: International Journal of Endocrinology and Metabolism
https://www.readbyqxmd.com/read/29278515/pegvisomant-primed-growth-hormone-gh-stimulation-test-is-useful-in-identifying-true-gh-deficient-children
#20
Giorgio Radetti, Heba H Elsedfy, Randa Khalaf, Cristina Meazza, Sara Pagani, Mohamed El Kholy, Riccardo Albertini, Anna Maria De Stefano, Antonella Navarra, Annalisa De Silvestri, Mauro Bozzola
OBJECTIVE: Provocative stimulation tests for growth hormone (GH) assessment have poor reproducibility and can often elicit false positive results in normal children. The aim of our study was to confirm the capability of pegvisomant as an enhancer of GH secretion in unmasking false-positive results in short children (height <-2.0 standard deviation score, SDS) undergoing GH testing. DESIGN: A prospective study was conducted between March and August 2016. Twenty short children (10 males and 10 females), aged 4...
July 2017: Hormones: International Journal of Endocrinology and Metabolism
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