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Hormones: International Journal of Endocrinology and Metabolism

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https://www.readbyqxmd.com/read/30306416/a-decade-of-thyroidology
#1
REVIEW
Petros Perros
Significant scientific progress has been achieved in the past decade in thyroidology driven by scholarly enquiry, unmet patient needs, and investment by the pharmaceutical and diagnostics industry. In this review, nine publications have been selected for their impact in pushing the frontiers of knowledge and understanding. They include new perspectives in the diagnosis, pathophysiology, epidemiology and management of thyroid cancer, understanding of thyroid hormone physiology, and new treatments for Graves' orbitopathy...
October 10, 2018: Hormones: International Journal of Endocrinology and Metabolism
https://www.readbyqxmd.com/read/30293227/pediatric-endocrinology-an-overview-of-the-last-decade
#2
REVIEW
Lourdes Ibáñez, Konstantina Barouti, Georgios K Markantes, Anastasia K Armeni, Neoklis A Georgopoulos
Over the past decade, considerable progress has been made in the field of pediatric endocrinology. However, there is still a long way to go regarding the exploration of novel avenues, such as epigenetics, the changing views on the pathophysiology and derived therapy of specific disorders, and the prevention of prevalent diseases. The next decade will hopefully bring the consolidation of most of those achievements and the development of new pathways for further progress.
October 6, 2018: Hormones: International Journal of Endocrinology and Metabolism
https://www.readbyqxmd.com/read/30284206/non-adenomatous-sellar-lesions-single-centre-10-year-experience
#3
Francisco Sousa Santos, Lídia Nunes Dias, Vanessa Henriques, Conceição Canas Marques, Martinha Chorão, João Sequeira Duarte, Clotilde Limbert, João Costa, Joana Graça, Carlos Vasconcelos, José Cabral, Sância Ramos
OBJECTIVE: A minority of lesions found in the sellar region are non-adenomatous neoplastic, inflammatory, or cystic masses. Our study aims to describe the prevalence and characteristics of these lesions in a multidisciplinary pituitary outpatient clinic. DESIGN: We conducted an observational study which included 36 patients (15.9% of those followed up in this outpatient clinic between 2006 and 2016 who had pituitary surgery) submitted to pituitary surgery with histological results showing a non-adenomatous sellar lesion...
October 3, 2018: Hormones: International Journal of Endocrinology and Metabolism
https://www.readbyqxmd.com/read/30280316/early-life-stress-and-trauma-developmental-neuroendocrine-aspects-of-prolonged-stress-system-dysregulation
#4
REVIEW
Agorastos Agorastos, Panagiota Pervanidou, George P Chrousos, Gerasimos Kolaitis
Experience of early life stress (ELS) and trauma is highly prevalent in the general population and has a high public health impact, as it can trigger a health-related risk cascade and lead to impaired homeostatic balance and elevated cacostatic load even decades later. The prolonged neuropsychobiological impact of ELS can, thus, be conceptualized as a common developmental risk factor for disease associated with increased physical and mental morbidity in later life. ELS during critical periods of brain development with elevated neuroplasticity could exert a programming effect on particular neuronal networks related to the stress response and lead to enduring neuroendocrine alterations, i...
October 2, 2018: Hormones: International Journal of Endocrinology and Metabolism
https://www.readbyqxmd.com/read/30267376/iodine-intake-and-chronic-autoimmune-thyroiditis-a-comparative-study-between-coastal-and-mainland-regions-in-greece
#5
Τ Giassa, I Mamali, Ε Gaki, G Kaltsas, G Kouraklis, Κ Β Markou, T Karatzas
INTRODUCTION: The purpose of this study was to evaluate the relationship between iodine intake and autoimmune thyroiditis in Chios, an island located in the North East Aegean Sea, in comparison to mainland regions in South Western Greece (SWG). MATERIALS AND METHODS: Urine iodine concentration (UIC), thyroid function (serum TSH, thyroid autoantibodies: anti-TPO and anti-Tg), and thyroid U/S were assessed in 200 subjects (150 females and 50 males) from Chios and 322 subjects (255 females and 67 males) from several mainland regions in SWG...
September 28, 2018: Hormones: International Journal of Endocrinology and Metabolism
https://www.readbyqxmd.com/read/30255482/the-role-of-vitamin-d-in-the-pathogenesis-and-treatment-of-diabetes-mellitus-a-narrative-review
#6
REVIEW
Maria Grammatiki, Spiros Karras, Kalliopi Kotsa
Diabetes mellitus, a metabolic disorder associated with chronic complications, is traditionally classified into two main subtypes. Type 1 diabetes mellitus (T1DM) results from gradual pancreatic islet β cell autoimmune destruction, extending over months or years. Type 2 diabetes mellitus (T2DM) is a heterogeneous disorder, with both insulin resistance and impairment in insulin secretion contributing to its pathogenesis. Vitamin D is a fat-soluble vitamin with an established role in calcium metabolism. Recently, several studies have provided evidence suggesting a role for it in various non-skeletal metabolic conditions, including both types of diabetes mellitus...
September 25, 2018: Hormones: International Journal of Endocrinology and Metabolism
https://www.readbyqxmd.com/read/30255481/growth-hormone-axis-in-patients-with-chronic-kidney-disease
#7
EDITORIAL
Stavroula Α Paschou, Christina Kanaka-Gantenbein, George P Chrousos, Andromachi Vryonidou
No abstract text is available yet for this article.
September 25, 2018: Hormones: International Journal of Endocrinology and Metabolism
https://www.readbyqxmd.com/read/30255480/unilateral-renal-agenesis-as-an-early-marker-for-genetic-screening-in-kallmann-syndrome
#8
LETTER
M I Stamou, L Plummer, A Galli-Tsinopoulou, D Stergidou, V Koika, N A Georgopoulos
No abstract text is available yet for this article.
September 25, 2018: Hormones: International Journal of Endocrinology and Metabolism
https://www.readbyqxmd.com/read/30255479/asymptomatic-and-normocalcemic-hyperparathyroidism-the-silent-attack-a-combo-endocrinology-overview
#9
REVIEW
Dimitrios A Anastasilakis, Polyzois Makras, Stergios A Polyzos, Athanasios D Anastasilakis
Asymptomatic primary hyperparathyroidism (PHPT) and the new variant of PHPT, normocalcemic PHPT, are considered by many physicians as mild, innocuous forms of disease, requiring nothing more than monitoring. Although this may be true in some cases in which the disease does not progress or cause complications, deterioration with more or less severe manifestations may occur. In the present review, we discuss the existing evidence of both the classic (skeletal and renal) and non-classic (cardiovascular, gastrointestinal, and psychiatric) features that have been attributed to asymptomatic and normocalcemic PHPT and the treatment effect on them...
September 25, 2018: Hormones: International Journal of Endocrinology and Metabolism
https://www.readbyqxmd.com/read/30229482/lipids-a-personal-view-of-the-past-decade
#10
REVIEW
Niki Katsiki, Dimitri P Mikhailidis
The past decade has witnessed considerable progress in the field of lipids. New drugs have been "rapidly" developed and some of these drugs have already been evaluated in event-based large trials. This evidence has led to the guidelines recommending new, more aggressive treatment goals for low-density lipoprotein cholesterol (LDL-C) levels. Although LDL-C remains the principal goal for cardiovascular disease (CVD) risk reduction, there has also been considerable interest in other lipid variables, such as high-density lipoprotein cholesterol, triglycerides, and lipoprotein(a)...
September 18, 2018: Hormones: International Journal of Endocrinology and Metabolism
https://www.readbyqxmd.com/read/30229481/further-data-corroborating-a-pituitary-contribution-to-the-genesis-of-the-cyclopean-myth
#11
LETTER
Elena Varotto, Emanuele Armocida
No abstract text is available yet for this article.
September 18, 2018: Hormones: International Journal of Endocrinology and Metabolism
https://www.readbyqxmd.com/read/30209779/vitamin-d-and-health-in-the-mediterranean-countries
#12
REVIEW
William B Grant
Vitamin D, traditionally well known for its role in maintaining optimal health through its contribution to calcium metabolism and skeletal health, has received increased attention over the past two decades, with considerable focus being placed on its nonskeletal benefits. This paper is a narrative review of the nonskeletal health benefits of vitamin D, of particular interest to inhabitants of Mediterranean countries, namely, autism, cancer, cardiovascular disease, chronic obstructive pulmonary disease, dental caries, diabetes mellitus, erectile dysfunction, hypertension, metabolic syndrome, respiratory tract infections, all-cause mortality, and pregnancy and birth outcomes, because of the relatively high incidence and/or prevalence of these disorders in this region...
September 12, 2018: Hormones: International Journal of Endocrinology and Metabolism
https://www.readbyqxmd.com/read/30178396/thyroid-stimulating-hormone-is-not-the-primary-regulator-of-thyroid-development-in-euthyroid-children-and-adolescents-living-in-an-iodine-replete-area
#13
Marina A Michalaki, Irene Mamali, Athanasios Tsekouras, Barbara Vlassopoulou, Eleni Anastasiou, Eftychia G Koukkou, Apostolos G Vagenakis, George Sakellaropoulos, Neoklis A Georgopoulos, Murod Rashitov, Bakhti Azizov, Said Ismailov, Kostas B Markou
OBJECTIVES: It is known that there are multiple factors which can affect thyroid gland development during childhood and adolescence. Our aim was to investigate this issue by examining the relationships between age, sex, several anthropometric parameters, pubertal status, thyroid function tests, and iodine intake status with thyroid volume (TV) in children and adolescents. STUDY DESIGN: This was a cross-sectional field study conducted in 11 representative cities and villages of Uzbekistan...
September 2018: Hormones: International Journal of Endocrinology and Metabolism
https://www.readbyqxmd.com/read/30171523/metabolic-syndrome-an-update-on-diagnostic-criteria-pathogenesis-and-genetic-links
#14
REVIEW
Uzma Zafar, Saba Khaliq, Hafiz Usman Ahmad, Sobia Manzoor, Khalid P Lone
Metabolic syndrome (MetS), today a major global public health problem, is a cluster of clinical, metabolic, and biochemical abnormalities, such as central adiposity, hypertension, insulin resistance, and dyslipidemias. These MetS-related traits significantly increase the risk of type 2 diabetes mellitus, adverse cardiac events, stroke, and hepatic steatosis. The pathogenesis of MetS is multifactorial, with the interplay of environmental, nutritional, and genetic factors. Chronic low-grade inflammation together with visceral adipose tissue, adipocyte dysfunction, and insulin resistance plays a major role in the progression of the syndrome by impairing lipid and glucose homeostasis in insulin-sensitive tissues, such as the liver, muscle, and adipocytes...
September 2018: Hormones: International Journal of Endocrinology and Metabolism
https://www.readbyqxmd.com/read/30168087/gonadotropin-releasing-hormone-gnrh-deficiency-under-treatment-psychological-and-sexual-functioning-impacts
#15
Neoklis A Georgopoulos, Anastasia K Armeni, Maria Stamou, Andromachi Kentrou, Evangelia Eirini Tsermpini, Gregoris Iconomou, Thomas Hyphantis, Konstantinos Assimakopoulos
OBJECTIVE: GnRH (gonadotropin releasing hormone) is a crucial hormone for sexual development, puberty, and fertility, and its deficiency leads to hypogonadotropic hypogonadism (HH), which causes abnormal secondary sexual development and infertility. The combination of the lack of sense of smell, i.e., anosmia, and HH is a type of GnRH deficiency known as Kallmann syndrome, which affects both men and women. The impact of Kallmann syndrome can be very severe and causes a variety of psychological problems in patients...
September 2018: Hormones: International Journal of Endocrinology and Metabolism
https://www.readbyqxmd.com/read/30132303/stem-cell-therapy-in-erectile-dysfunction-science-fiction-or-realistic-treatment-option
#16
Ioannis Vakalopoulos, Dimitrios Memmos, Ioannis Mykoniatis, Chrysovalantis Toutziaris, Georgios Dimitriadis
Stem cell therapy has become a subject of great interest to researchers worldwide. One of the medical conditions being studied for possible treatment with the use of stem cells is erectile dysfunction, and particularly organic and post-radical prostatectomy erectile dysfunction. However, is stem cell therapy a viable treatment option for erectile dysfunction? The current body of literature provides a wide array of clinical trials performed on animal models simulating different types of human erectile dysfunction...
September 2018: Hormones: International Journal of Endocrinology and Metabolism
https://www.readbyqxmd.com/read/30112705/significant-effect-of-group-education-in-patients-with-diabetes-type-1
#17
Zadalla Mouslech, Maria Somali, Livadas Sarantis, Daramilas Christos, Chatzi Alexandra, Papagianni Maria, George Mastorakos, Christos Savopoulos, Apostolos I Hatzitolios
OBJECTIVE: Type 1 diabetes mellitus (T1DM) constitutes a real challenge in everyday practice for both physicians and patients. Due to the complexity of the disease and its unpredictable nature, structured education and training programs are nowadays implemented that ensure active patient involvement and self-care behaviors to achieve adequate glycemic control, prevent diabetic complications, and improve the quality of life of patients. These programs provide patients with the necessary knowledge and skills to self-monitor and self-manage the disease and its associated metabolic conditions...
September 2018: Hormones: International Journal of Endocrinology and Metabolism
https://www.readbyqxmd.com/read/30105568/brain-activation-during-repeated-imagining-of-chocolate-consumption-a-functional-magnetic-resonance-imaging-study
#18
Dimitrios N Kiortsis, Panagiota Spyridonos, Persefoni N Margariti, Vassileios Xydis, George Alexiou, Loukas G Astrakas, Maria I Argyropoulou
OBJECTIVE: To assess brain activation during mental visualization of eating chocolate. DESIGN: Twenty-one subjects were included. FMRI was acquired with a single-shot, multislice, gradient echo-planar sequence, while subjects were performing two specific imaginary tasks. RESULTS: Activation of motor-associated brain areas was observed during both mental visualization tasks. Increased activation of the right dorsolateral prefrontal cortex, the thalamus, the postcentral gyrus and the left anterior cingulate cortex, and the precuneus was observed during imagining eating chocolate...
September 2018: Hormones: International Journal of Endocrinology and Metabolism
https://www.readbyqxmd.com/read/30099726/the-effectiveness-of-a-health-promotion-and-stress-management-intervention-program-in-a-sample-of-obese-children-and-adolescents
#19
Chrysoula-Christina Emmanouil, Panagiota Pervanidou, Evangelia Charmandari, Christina Darviri, George P Chrousos
OBJECTIVE: Our study aimed to evaluate the effectiveness of an 8-week stress management intervention program that included progressive muscle relaxation, diaphragmatic breathing, guided imagery, and cognitive restructuring in obese Greek children and adolescents. DESIGN: Thirty-six patients were prospectively recruited to participate in this randomized controlled study. Of these, 16 participants formed the intervention group and 20 participants the control group...
September 2018: Hormones: International Journal of Endocrinology and Metabolism
https://www.readbyqxmd.com/read/30083881/a-novel-germline-mutation-at-exon-10-of-men1-gene-a-clinical-survey-and-positive-genotype-phenotype-analysis-of-a-men1-italian-family-including-monozygotic-twins
#20
REVIEW
Andrea Palermo, Ettore Capoluongo, Rossella Del Toro, Silvia Manfrini, Paolo Pozzilli, Daria Maggi, Giuseppe Defeudis, Francesco Pantano, Roberto Coppola, Francesco Maria Di Matteo, Marco Raffaelli, Paola Concolino, Alberto Falchetti
CONTEXT: Clinical phenotype variability in MEN1 syndrome exists and evidence for an established genotype-phenotype is lacking. However, a higher aggressiveness of MEN1-associated gastro-entero-pancreatic (GEP) (neuro)endocrine tumours (NETs) tumours has been reported when MEN1 gene truncating mutations are detected. We found a novel germline truncating mutation of MEN1 gene at exon 10 in a subject with an aggressive clinical behavior of GEP-NETs. Successively, other two mutant-affected familial members have been identified...
September 2018: Hormones: International Journal of Endocrinology and Metabolism
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