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Hormones: International Journal of Endocrinology and Metabolism

Zadalla Mouslech, Maria Somali, Livadas Sarantis, Daramilas Christos, Chatzi Alexandra, Papagianni Maria, George Mastorakos, Christos Savopoulos, Apostolos I Hatzitolios
OBJECTIVE: Type 1 diabetes mellitus (T1DM) constitutes a real challenge in everyday practice for both physicians and patients. Due to the complexity of the disease and its unpredictable nature, structured education and training programs are nowadays implemented that ensure active patient involvement and self-care behaviors to achieve adequate glycemic control, prevent diabetic complications, and improve the quality of life of patients. These programs provide patients with the necessary knowledge and skills to self-monitor and self-manage the disease and its associated metabolic conditions...
August 15, 2018: Hormones: International Journal of Endocrinology and Metabolism
Dimitrios N Kiortsis, Panagiota Spyridonos, Persefoni N Margariti, Vassileios Xydis, George Alexiou, Loukas G Astrakas, Maria I Argyropoulou
OBJECTIVE: To assess brain activation during mental visualization of eating chocolate. DESIGN: Twenty-one subjects were included. FMRI was acquired with a single-shot, multislice, gradient echo-planar sequence, while subjects were performing two specific imaginary tasks. RESULTS: Activation of motor-associated brain areas was observed during both mental visualization tasks. Increased activation of the right dorsolateral prefrontal cortex, the thalamus, the postcentral gyrus and the left anterior cingulate cortex, and the precuneus was observed during imagining eating chocolate...
August 13, 2018: Hormones: International Journal of Endocrinology and Metabolism
Chrysoula-Christina Emmanouil, Panagiota Pervanidou, Evangelia Charmandari, Christina Darviri, George P Chrousos
OBJECTIVE: Our study aimed to evaluate the effectiveness of an 8-week stress management intervention program that included progressive muscle relaxation, diaphragmatic breathing, guided imagery, and cognitive restructuring in obese Greek children and adolescents. DESIGN: Thirty-six patients were prospectively recruited to participate in this randomized controlled study. Of these, 16 participants formed the intervention group and 20 participants the control group...
August 11, 2018: Hormones: International Journal of Endocrinology and Metabolism
Andrea Palermo, Ettore Capoluongo, Rossella Del Toro, Silvia Manfrini, Paolo Pozzilli, Daria Maggi, Giuseppe Defeudis, Francesco Pantano, Roberto Coppola, Francesco Maria Di Matteo, Marco Raffaelli, Paola Concolino, Alberto Falchetti
CONTEXT: Clinical phenotype variability in MEN1 syndrome exists and evidence for an established genotype-phenotype is lacking. However, a higher aggressiveness of MEN1-associated gastro-entero-pancreatic (GEP) (neuro)endocrine tumours (NETs) tumours has been reported when MEN1 gene truncating mutations are detected. We found a novel germline truncating mutation of MEN1 gene at exon 10 in a subject with an aggressive clinical behavior of GEP-NETs. Successively, other two mutant-affected familial members have been identified...
August 6, 2018: Hormones: International Journal of Endocrinology and Metabolism
Stergios A Polyzos, Andrew N Margioris
Sarcopenic obesity, a chronic condition, is today a major public health problem with increasing prevalence worldwide, which is due to progressively aging populations, the increasing prevalence of obesity, and the changes in lifestyle during the last several decades. Patients usually present to healthcare facilities for obesity and related comorbidities (type 2 diabetes mellitus, non-alcoholic fatty liver disease, dyslipidemia, hypertension, and cardiovascular disease) or for non-specific symptoms related to sarcopenia per se (e...
July 16, 2018: Hormones: International Journal of Endocrinology and Metabolism
Dimitrios T Papadimitriou, Christina Bothou, Diagoras Zarganis, Maria Karantza, Anastasios Papadimitriou
The first and rate-limited step of steroidogenesis in all steroidogenic tissues is the conversion of cholesterol to pregnenolone, catalysed by P450scc side-chain cleavage enzyme (CYP11A1 gene-SCC). SCC deficiency has been characterised as an autosomal recessive disorder, although it may also be inherited as an autosomal dominant trait in humans. Here, we describe a family of three members carrying the same novel heterozygous CYP11A1 mutation, a c.235G > A missense variant in exon 1: pVal79Ile. A 46 XY boy (P1) was presented at the age of 3 months with early onset adrenal insufficiency and life-threatening failure to thrive, with low adrenal androgens but normal external genitalia...
July 11, 2018: Hormones: International Journal of Endocrinology and Metabolism
Maswood M Ahmad, Badurudeen Mahmood Buhary, Fatima Al Mousawi, Fahad Alshahrani, Imad Brema, Khalid M Al Dahmani, Salem A Beshyah, Mussa H AlMalki
BACKGROUND: Worldwide variations exist in the diagnosis and management of patients with acromegaly. For such a rare condition, the knowledge and perception of physicians would most likely direct the care of patients. However, the adherence of physicians in non-Western regions to guidelines for the diagnosis and management of acromegaly has not been previously ascertained. METHODS: An online survey was conducted to assess the perceptions and practice of physicians regarding acromegaly diagnosis and management as per international guidelines...
July 3, 2018: Hormones: International Journal of Endocrinology and Metabolism
Konstantinos Katsoulis, Stavroula A Paschou, Elissavet Hatzi, Stelios Tigas, Ioannis Georgiou, Agathocles Tsatsoulis
INTRODUCTION: Transcription factor 7-like 2 (TCF7L2) gene variants rs12255372 and rs7903146 have been consistently shown to raise genetic risk for type 2 diabetes mellitus (T2DM). The aim of this study was to investigate the possible role of these variants in the development of impaired glucose metabolism (IGM), including impaired fasting glucose (IFG) or T2DM, in patients with metabolic syndrome (MS). PATIENTS AND METHODS: The study population consisted of 228 patients with MS who were divided into two groups...
July 3, 2018: Hormones: International Journal of Endocrinology and Metabolism
Christoforos Efthymiou, Dionisios Spyratos, Theodore Kontakiotis
Paraneoplastic syndromes are defined as a combination of clinical disorders associated with malignant diseases that are caused by the secretion of various substances by the tumor without, however, being caused by the direct growth and infiltration of the primary tumor, or due to the development of distant metastases. Despite the fact that lung cancer represents the number one cause of death from cancer worldwide, the new methods of treatment increase patient survival and the incidence of paraneoplastic syndromes...
July 2, 2018: Hormones: International Journal of Endocrinology and Metabolism
Sezer Acar, Nur Arslan, Ahu Paketçi, Tuncay Derya Okur, Korcan Demir, Ece Böber, Ayhan Abacı
Tay-Sachs disease is an autosomal recessive type of lysosomal storage disorder. The disease is very rare in Turkey, with an incidence of 0.54/100,000. The clinical manifestations of Tay-Sachs disease include progressive developmental delay, seizures, deafness, blindness, spasticity, and dystonia, which are caused by the accumulation of gangliosides in the central nervous system. To date, only one case indicating the association between Tay-Sachs disease and central precocious puberty has been reported. Although the mechanism of this association is not clear, it is thought to be due to ganglioside accumulation in the central nervous system or the inhibition of the hypothalamic inhibiting pathway...
June 25, 2018: Hormones: International Journal of Endocrinology and Metabolism
Sevasti Konstantinidou, Eirini Konstantinidou
Thyroidology is a discipline of Endocrinology which has evolved markedly over the past few decades. However, its historical roots can be seen in the literature of, among others, ancient Greek medicine. In the present article, we present the descriptions of the thyroid gland by ancient Greek physicians and its depiction in ancient Greek art.
June 19, 2018: Hormones: International Journal of Endocrinology and Metabolism
Antonis Makrigiannakis, Thomas Vrekoussis, Emmanouel Zoumakis, Vassilia Hatzidakis, Eugenia Vlachou, Nicolaos Salakos, Sophia N Kalantaridou
Endometrial corticotropin-releasing hormone (CRH) has been described as a mediator of decidualisation and as a contributor of maternal-fetal immunotolerance. Deregulation of the CRH expression pattern has been associated with unfavourable reproductive outcomes as well as chronic endometrium-derived inflammatory disorders, such as endometriosis and adenomyosis. The current review summarises the evidence produced regarding the role of CRH in endometrial physiology and pathophysiology and highlights recent clinical data regarding the role of CRH in improving clinical pregnancy rates in women with repeated implantation failures following in vitro fertilisation and embryo transfer...
June 18, 2018: Hormones: International Journal of Endocrinology and Metabolism
Salvatore Minisola, Jessica Pepe, Pietro Donato, Evelina Vigna, Marco Occhiuto, Federica Ferrone, Federica Biamonte, Veronica Cecchetti, Vittoria Carmela Danese, Chiara Sonato, Piergianni BIondi, Luciano Colangelo, Cristiana Cipriani
No abstract text is available yet for this article.
June 12, 2018: Hormones: International Journal of Endocrinology and Metabolism
Dimitrios Sfairopoulos, Stavros Liatis, Stelios Tigas, Evangelos Liberopoulos
Glucagon-like peptide-1 receptor agonists (GLP-1 RAs) are an important asset in the armamentarium for the treatment of type 2 diabetes mellitus (type 2 DM). Incretin failure is a critical etiopathogenetic feature of type 2 DM, which, if reversed, results in improved glycaemic control. GLP-1 RAs are injectable peptides that resemble the structure and function of endogenous incretin GLP-1, but as they are not deactivated by the dipeptidyl peptidase-4 (DPP-4), their half-life is prolonged compared with native GLP-1...
June 12, 2018: Hormones: International Journal of Endocrinology and Metabolism
Kristy L Meadows
Ischemic stroke is the fifth leading cause of death in the USA and is the leading cause of serious, long-term disability worldwide. The principle sex hormones (estrogen, progesterone, and testosterone), both endogenous and exogenous, have profound effects on various stroke outcomes and have become the focus of a number of studies evaluating risk factors and treatment options for ischemic stroke. In addition, the expression of other hormones that may influence stroke outcome, including select adipose-derived hormones (adiponectin, leptin, and ghrelin), can be regulated by sex hormones and are also the focus of several ischemic stroke studies...
June 6, 2018: Hormones: International Journal of Endocrinology and Metabolism
Evangelia Triantafyllou, Maria P Yavropoulou, Athanasios D Anastasilakis, Polyzois Makras
Hypoparathyroidism is a relatively rare endocrine disease characterised by either null or inappropriately low secretion of parathyroid hormone (PTH) for serum calcium levels. The other main laboratory findings include hypocalcaemia, inappropriately normal or high urine calcium excretion and hyperphosphataemia with low urine phosphate excretion. The management of hypoparathyroidism should be tailored to each individual case, which makes it a demanding undertaking in everyday clinical practice. In this review, we sought to focus on the diagnostic approach of hypoparathyroidism and the therapeutic challenges of the disease from a clinical perspective...
June 6, 2018: Hormones: International Journal of Endocrinology and Metabolism
Ana Valea, Carmen Emanuela Georgescu
Selenium (Se) has a multilevel, complex and dynamic effect on the human body as a major component of selenocysteine, incorporated into selenoproteins, which include the selenocysteine-containing enzymes iodothyronine deiodinases. At the thyroid level, these proteins play an essential role in antioxidant protection and hormone metabolism. This is a narrative review based on PubMed/Medline database research regarding thyroid physiology and conditions with Se and Se-protein interferences. In humans, Se-dependent enzyme functions are best expressed through optimal Se intake, although there is gap in our knowledge concerning the precise mechanisms underlying the interrelation...
June 5, 2018: Hormones: International Journal of Endocrinology and Metabolism
Matteo Zoli, Federica Guaraldi, Marco Faustini, Diego Mazzatenta
Myasthenia gravis (MG) is an autoimmune disease affecting neuromuscular transmission that manifests with muscle weakness and typically involves the eye muscles, often producing diplopia and ptosis. Recent studies suggest that hyperprolactinaemia may have a role in the development of MG, although its association with prolactinoma is extremely rare. We report the unusual case of a 71-year-old male affected with macroprolactinoma, who presented at our Center 2 weeks after starting cabergoline treatment because of acute onset of headache, diplopia, and ptosis...
June 2, 2018: Hormones: International Journal of Endocrinology and Metabolism
Michael Apostolakis, Stavroula A Paschou, Evangelia Zapanti, Vasiliki Sarantopoulou, Vasiliki Vasileiou, Eleni Anastasiou
BACKGROUND AND AIM: Women with a history of gestational diabetes mellitus (GDM) are at increased risk for type 2 diabetes (T2D). It is thus recommended that an oral glucose tolerance test (OGTT) be performed after delivery. Recently, the use of glycated haemoglobin A1c (HbA1c) has been proposed as a simpler and faster method to diagnose glucose disorders. The aim of this study was to investigate whether HbA1c measurement can replace OGTT in the detection of prediabetes and T2D in women with a history of GDM...
June 2018: Hormones: International Journal of Endocrinology and Metabolism
Banu Sarer Yurekli, Gokcen Unal Kocabas, Murat Aksit, Nilufer Ozdemir Kutbay, Aslı Suner, Ismail Yurekli, Habib Cakir, Giray Bozkaya, Sevki Cetinkalp
OBJECTIVE: Bone morphogenic protein-4 (BMP-4) is a proinflammatory cytokine which is controlled by BMP-4 antagonists. Our aim was to investigate the levels of BMP-4 and its antagonists, noggin and matrix Gla protein (MGP), in prediabetes and diabetes. DESIGN: One hundred and forty-two type 2 diabetic, 32 prediabetic, and 58 control subjects participated in this cross-sectional study. BMP-4, noggin, and MGP were measured with the ELISA method. RESULTS: There was a significant difference between the three groups in relation to sex, hypertension, fasting plasma glucose, HbA1c, lipid profiles, and diastolic blood pressure (p < 0...
June 2018: Hormones: International Journal of Endocrinology and Metabolism
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