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Journal of Clinical and Experimental Hematopathology: JCEH

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https://www.readbyqxmd.com/read/29657256/colonal-monomorphic-epitheliotropic-intestinal-t-cell-lymphoma-with-novel-phenotype-of-cytoplasmic-cd3-expression
#1
Yumi Aoyama, Hiroko Tsunemine, Yuriko Zushi, Hayato Maruoka, Yuta Goto, Taiichi Kodaka, Tomoo Itoh, Takayuki Takahashi
Monomorphic epitheliotropic intestinal T-cell lymphoma (MEITL) is a new clinical entity that was reclassified from enteropathy-associated T-cell lymphoma in the 2016 WHO classification. An 83-year-old man with fever and diarrhea was referred to our hospital because of free air in the abdominal cavity and wall thickening of the large intestine on CT. Colonofiberscopic examination revealed mucosal edema and multiple ulcers at the sigmoid colon, splenic flexure, and transverse colon. Histopathological examination of the mucosal biopsy specimen demonstrated dense infiltration of small lymphocytes with nuclear atypia, some of which exhibited intraepithelial invasion...
April 13, 2018: Journal of Clinical and Experimental Hematopathology: JCEH
https://www.readbyqxmd.com/read/29657255/genome-wide-sirna-screening-in-mouse-bone-marrow-derived-macrophages-revealed-that-knockdown-of-ribosomal-proteins-suppresses-il-10-and-enhances-tnf-%C3%AE-production
#2
Yoshihiko Okamura, Naoyuki Makita, Yoshiyuki Hizukuri, Yasuhiro Hayashi
Macrophages play a central role in the immune response, and their diverse functions are attributed to the spectrum of their functional states. To elucidate molecules involved in modulating the balance between the anti-inflammatory cytokine IL-10 and the pro-inflammatory cytokine TNF-α, we conducted genome-wide siRNA screening. First, we established an siRNA screening system using mouse bone marrow-derived macrophages, which are a suitable model for studying functional states of macrophages in vitro. In the primary screen and the subsequent reproducibility assay, 112 siRNA pools demonstrated enhancement of IL-10 production and 497 siRNA pools suppressed IL-10 production...
April 13, 2018: Journal of Clinical and Experimental Hematopathology: JCEH
https://www.readbyqxmd.com/read/29415979/autopsy-case-report-of-intravascular-large-b-cell-lymphoma-with-neoplastic-pd-l1-expression
#3
Ayako Sakakibara, Yuichiro Inagaki, Eiki Imaoka, Eri Ishikawa, Satoko Shimada, Kazuyuki Shimada, Yuka Suzuki, Shigeo Nakamura, Akira Satou, Kei Kohno
Intravascular large B-cell lymphoma (IVLBCL) is a rare and clinically distinctive entity characterized by the almost exclusive growth of large cells within the lumen of blood vessels in particular capillaries. Reports of this peculiar disease, do not commonly address the PD-L1 expression on IVLBCL tumor cells. Here, we describe a 51-year-old Japanese woman who presented with rapidly progressive cognitive decline and higher brain dysfunction. CT scan and MRI revealed multiple ischemic foci in the cerebral hemispheres, ground-glass opacity in the lungs, and splenomegaly...
March 16, 2018: Journal of Clinical and Experimental Hematopathology: JCEH
https://www.readbyqxmd.com/read/29415978/hyaline-vascular-castleman-s-disease-representing-18-trisomy
#4
Masaru Kojima, Seiichi Shimizu
No abstract text is available yet for this article.
March 16, 2018: Journal of Clinical and Experimental Hematopathology: JCEH
https://www.readbyqxmd.com/read/29415977/composite-lymphoma-as-co-occurrence-of-advanced-chronic-lymphocytic-leukemia-small-lymphocytic-lymphoma-carrying-trisomy-12-and-t-14-18-and-peripheral-t-cell-lymphoma
#5
Yumi Aoyama, Taiichi Kodaka, Yuriko Zushi, Yuta Goto, Hiroko Tsunemine, Tomoo Itoh, Takayuki Takahashi
Composite lymphoma is defined as the co-occurrence of two types of lymphoma, comprising 1-4% of lymphomas, and the association of B-cell-type chronic lymphocytic leukemia (B-CLL)/small lymphocytic lymphoma and peripheral T-cell lymphoma (PTCL) is rare. Here, we report a case (77-year-old woman) of advanced B-CLL complicated by newly appearing PTCL. Two years after the onset of B-CLL, CLL cells acquired CD38 antigen expression and the disease entity became CLL/prolymphocytic leukemia. Trisomy 12 and t(14;18) karyotypes were observed...
March 16, 2018: Journal of Clinical and Experimental Hematopathology: JCEH
https://www.readbyqxmd.com/read/29415976/clinical-management-and-outcomes-of-completely-resected-stage-i-follicular-lymphoma
#6
Akihiko Yokohama, Yoko Hashimoto, Makiko Takizawa, Hiroaki Shimizu, Yuri Miyazawa, Akio Saitoh, Kohtaro Toyama, Takuma Ishizaki, Takeki Mitsui, Takayuki Saitoh, Kayoko Murayama, Morio Matsumoto, Morio Sawamura, Hirokazu Murakami, Junko Hirato, Masaru Kojima, Yoshihisa Nojima, Hiroshi Handa, Norifumi Tsukamoto
Recent studies have revealed the clinical and biological features of stage I follicular lymphoma (FL), but information about patients with stage I FL who underwent total resection after tissue biopsy is limited. Among 305 FL patients diagnosed between 2001 and 2013, clinical stage I disease was observed in 36 patients. Of these, 18 patients underwent total resection after diagnostic tissue biopsy. We used 18 F-fluorodeoxyglucose positron emission CT for staging assessment in 13 of 18 patients (72.2%). The median age was 56...
March 16, 2018: Journal of Clinical and Experimental Hematopathology: JCEH
https://www.readbyqxmd.com/read/29415975/detection-of-minimal-bone-marrow-involvement-of-blastic-plasmacytoid-dendritic-cell-neoplastic-cells-cd303-immunostaining-as-a-diagnostic-tool
#7
Rintaro Ohe, Naing Ye Aung, Yosuke Shiono, Aya Utsunomiya, Takanobu Kabasawa, Nobuyuki Tamazawa, Yuka Tamura, Tomoya Kato, Akane Yamada, Shin Hasegawa, Keiko Aizawa, Kyoko Inokura, Satoshi Ito, Tomomi Toubai, Yuichi Kato, Takahiko Tsunoda, Kosuke Onami, Tamio Suzuki, Kenichi Ishizawa, Mitsunori Yamakawa
Blastic plasmacytoid dendritic cell (pDC) neoplasm (BPDCN) is a relatively rare hematological malignancy with significantly complex clinicopathological features that are still unclear. This study aimed to analyze the clinicopathological data of BPDCN and evaluate immunohistochemical detection of minimal bone marrow (BM) involvement. In this study, we examined skin and BM lesions from 6 patients with BPDCN. Neoplastic cells tested positive for CD303 (polyclonal, 100%; monoclonal, 40%) in the skin lesions and for CD303 (polyclonal, 100%; monoclonal, 67%) in the BM clots...
March 16, 2018: Journal of Clinical and Experimental Hematopathology: JCEH
https://www.readbyqxmd.com/read/29415974/a-case-of-classical-hodgkin-lymphoma-with-total-lymph-node-infarction
#8
Marika Okuni, Kimikazu Yakushijin, Yasuhiro Sakai, Hirotaka Suto, Hiroya Ichikawa, Rina Sakai, Seiji Kakiuchi, Keiji Kurata, Yu Mizutani, Akihito Kitao, Yoshiharu Miyata, Yasuyuki Saito, Shinichiro Kawamoto, Katsuya Yamamoto, Mitsuhiro Ito, Hiroshi Matsuoka, Hironobu Minami
Lymph node infarction is very rare, and is frequently associated with neoplasms, such as malignant lymphoma and non-neoplastic disease, or interventions such as fine-needle aspiration (FNA). A 76-year-old-man presented with cervical lymph node swelling. Although FNA was performed, the findings were insufficient for a definitive diagnosis. Consequently, surgical biopsy of the cervical lymph node was performed, which revealed total infarction; a diagnosis of classical Hodgkin lymphoma was made later. Both lymphoma itself and FNA may cause total lymph node infarction, which makes diagnosis confusing...
March 16, 2018: Journal of Clinical and Experimental Hematopathology: JCEH
https://www.readbyqxmd.com/read/29998979/the-expression-of-pd-1-ligands-and-ido1-by-macrophage-microglia-in-primary-central-nervous-system-lymphoma
#9
Yuko Miyasato, Yasuo Takashima, Hiroto Takeya, Hiromu Yano, Azusa Hayano, Takenobu Nakagawa, Keishi Makino, Motohiro Takeya, Ryuya Yamanaka, Yoshihiro Komohara
Recent progress in anti-tumor immunotherapy has focused on the significance of the tumor microenvironment in tumor progression and resistance to chemo/radio-therapy. Myeloid cells such as macrophages are predominant stromal components in hematological malignancies. In the present study, we investigated the regulation of programmed death-1 (PD-1) ligand expression in primary central nervous system lymphoma (PCNSL) using PCNSL cell lines and human monocyte-derived macrophages. TK PCNSL cell line-derived soluble factors induced overexpression of PD-1 ligands, indoleamine 2,3-dioxygenase (IDO1), and several other cytokines in macrophages...
2018: Journal of Clinical and Experimental Hematopathology: JCEH
https://www.readbyqxmd.com/read/29998978/the-histopathology-of-bone-marrow-failure-in-children
#10
Hideto Iwafuchi
Bone marrow failure (BMF) is a rare but life-threatening disorder that usually manifests as (pan)cytopenia. BMF can be caused by a variety of diseases, but inherited BMF (IBMF) syndromes are a clinically important cause, especially in children. IBMF syndromes are a heterogeneous group of genetic disorders characterized by BMF, physical abnormalities, and predisposition to malignancy. An accurate diagnosis is critical, as disease-specific management, surveillance, and genetic counselling are required for each patient...
2018: Journal of Clinical and Experimental Hematopathology: JCEH
https://www.readbyqxmd.com/read/29998977/the-histopathology-of-myeloma-in-the-bone-marrow
#11
Masahiko Fujino
Myeloma is characterized by the neoplastic proliferation of monoclonal plasma cells. A diagnosis of myeloma is based on the criteria proposed by the International Myeloma Working Group and the pathological findings.Myeloma cells are classified into four types: mature, immature, pleomorphic, and plasmablastic. There are three patterns in which myeloma infiltrates bone marrow - nodular, interstitial, and diffuse. Dutcher bodies are highly specific to neoplastic myeloma cells. On immunohistochemical staining, the specificity of CD138 is high for plasma cells...
2018: Journal of Clinical and Experimental Hematopathology: JCEH
https://www.readbyqxmd.com/read/29998976/histopathology-in-the-diagnosis-of-high-risk-myelodysplastic-syndromes
#12
Hidekazu Kayano
No abstract text is available yet for this article.
2018: Journal of Clinical and Experimental Hematopathology: JCEH
https://www.readbyqxmd.com/read/29998975/histological-evaluation-of-myeloproliferative-neoplasms
#13
Hideyo Fujiwara
In 2017, the revised World Health Organization was published. Regarding myeloproliferative neoplasms, histological findings of bone marrow biopsy is becoming more important for diagnosis. This article highlights particularly the morphology of megakaryocytes and evaluation of myelofibrosis for pathological diagnosis, and immunohistochemistry which can detect somatic mutation.
2018: Journal of Clinical and Experimental Hematopathology: JCEH
https://www.readbyqxmd.com/read/29998974/highlights-focus-on-bone-marrow-pathology
#14
Masafumi Ito
No abstract text is available yet for this article.
2018: Journal of Clinical and Experimental Hematopathology: JCEH
https://www.readbyqxmd.com/read/29553093/anaplastic-multiple-myeloma-possible-limitations-of-conventional-chemotherapy-for-long-term-remission
#15
Satoshi Ichikawa, Noriko Fukuhara, Shunsuke Hatta, Masahito Himuro, Kentaro Nasu, Koya Ono, Yoko Okitsu, Masahiro Kobayashi, Yasushi Onishi, Masaki Ri, Ryo Ichinohasama, Hideo Harigae
No abstract text is available yet for this article.
2018: Journal of Clinical and Experimental Hematopathology: JCEH
https://www.readbyqxmd.com/read/29553092/natural-compounds-that-regulate-lymph-node-sinus-macrophages-inducing-an-anti-tumor-effect-by-regulating-macrophage-activation
#16
Yukio Fujiwara, Yoichi Saito, Takuya Shiota, Pan Cheng, Tsuyoshi Ikeda, Koji Ohnishi, Motohiro Takeya, Yoshihiro Komohara
Recent progress in anti-tumor therapy has revealed the significance of anti-tumor immune responses in tumor progression and clinical course in several kinds of malignant tumors. The draining lymph node is an important immune system component that contains a number of antigen-presenting cells, which induce rapid immune responses to foreign antigens. Current studies have shown that higher expression of CD169 on lymph node sinus macrophages is associated with the induction of anti-tumor immunity. In the present study, we searched for natural compounds that regulate the CD169-positive phenotype in macrophages to identify potential new anti-cancer agents targeting macrophage activation...
2018: Journal of Clinical and Experimental Hematopathology: JCEH
https://www.readbyqxmd.com/read/28679966/current-treatment-approaches-for-nk-t-cell-lymphoma
#17
Motoko Yamaguchi, Kana Miyazaki
Extranodal NK/T-cell lymphoma, nasal type (ENKL), is a form of lymphoma characterized by preferential extranodal involvement, Epstein-Barr virus (EBV) association, and geographic diversity in incidence. ENKL tumor cells express P-glycoprotein, which is related to multidrug resistance (MDR). This MDR phenomenon is thought to be the major reason why ENKL is resistant to anthracycline-containing chemotherapies and has led researchers to explore novel therapeutic strategies. Since the early 2000s, next-generation therapies, including upfront radiotherapy, chemotherapy, or concurrent chemoradiotherapy using non-MDR-related drugs, have markedly changed the management of ENKL...
December 27, 2017: Journal of Clinical and Experimental Hematopathology: JCEH
https://www.readbyqxmd.com/read/28592744/treatment-advances-and-prognosis-for-patients-with-adult-t-cell-leukemia-lymphoma
#18
Hiroo Katsuya, Kenji Ishitsuka
A classification for adult T-cell leukemia-lymphoma (ATL) based on clinical features was proposed in 1991: acute, lymphoma, chronic, and smoldering types, and their median survival times (MSTs) were reported to be 6.2, 10.2, 24.3 months, and not reached, respectively. Several new therapies for ATL have since been developed, i.e. dose-intensity multi-agent chemotherapies, allogeneic hematopoietic stem cell transplantation (allo-HSCT), monoclonal antibodies, and anti-viral therapy. The monoclonal antibody to CCR4, mogamulizumab, clearly improved response rates in patients with treatment-naïve and relapsed aggressive ATL, and has the potential to provide a survival advantage...
December 27, 2017: Journal of Clinical and Experimental Hematopathology: JCEH
https://www.readbyqxmd.com/read/28883221/welder-s-pulmonary-hemosiderosis-associated-with-systemic-iron-overload-following-exacerbation-of-acute-adult-t-cell-leukemia-lymphoma
#19
Naoto Imoto, Akira Shiraki, Katsuya Furukawa, Naoyuki Tange, Atsushi Murase, Masaya Hayakawa, Yosuke Iwata, Hiroshi Kosugi
Herein, we describe a 61-year-old man diagnosed with pulmonary hemosiderosis following chemotherapy for acute adult T-cell leukemia/lymphoma (ATLL). Liver and heart biopsy confirmed hemosiderosis. ATLL progressed, and the patient died from multiorgan damage. Welder's lung may have been involved in hemosiderosis and systemic iron overload. Abnormal iron metabolism or immune reactions may have influenced the clinical course, but these were not validated. Detailed analyses of family medical and lifestyle histories, and genetic examination should be performed in cases of systemic iron overload...
October 12, 2017: Journal of Clinical and Experimental Hematopathology: JCEH
https://www.readbyqxmd.com/read/28883219/high-dose-chemotherapy-with-autologous-stem-cell-transplantation-following-systemic-chemotherapy-prophylactic-intrathecal-methotrexate-and-radiotherapy-prevents-relapse-and-improves-the-outcome-of-advanced-stage-primary-testicular-lymphoma-even-with-cardiac
#20
Shin Lee, Takahiro Yamauchi, Keiichi Kinoshita, Shin Imamura, Kenichi Kamiya
Primary testicular lymphoma (PTL) is a rare but aggressive disease. Although most patients present in the early stage, their prognosis is poor. Similar with PTL, cardiac lymphoma is also an uncommon disease characterized by its aggressive clinical course and poor prognosis. We herein report an extremely rare case of advanced stage PTL with cardiac involvement, treated by high-dose chemotherapy with autologous stem cell transplantation (HDT-ASCT) followed by systemic chemotherapy, prophylactic intrathecal methotrexate (IT-MTX), and radiotherapy...
October 12, 2017: Journal of Clinical and Experimental Hematopathology: JCEH
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