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Journal of Clinical and Experimental Hematopathology: JCEH

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https://www.readbyqxmd.com/read/30089750/pulmonary-extranodal-marginal-zone-lymphoma-that-presented-with-macroglobulinemia-and-marked-plasmacytic-cell-proliferation-carrying-the-t-14-18-q32-q21-malt1-immunoglobulin-heavy-chain-fusion-gene-in-pleural-fluid
#1
Takashi Akasaka, Chiyuki Kishimori, Fumiyo Maekawa, Kayo Takeoka, Masahiko Hayashida, Hiroshi Gomyo, Tohru Murayama, Hitoshi Ohno
An 80-year-old man presented with the accumulation of pleural fluid in the right thoracic cavity. Serum electrophoresis revealed an M-component and immunofixation confirmed IgM/λ. The level of IgM was 1,526 mg/dL. Imaging studies showed an infiltrative condition of the ipsilateral lung parenchyma. The fluid contained abundant neoplastic cells with the morphological and immunophenotypic features of plasma cells, which expressed IgM/λ monoclonal immunoglobulins on the cell surface and in the cytoplasm. The karyotype was 48,XY,+3,add(9)(p13),+12,add(14)(q32),del(16)(q22),-18,+mar, and a series of fluorescence in situ hybridization studies demonstrated that the add(14) chromosome represented der(14)t(14;18)(q32;q21), at which the MALT1-immunoglobulin heavy-chain (IGH) fusion gene was localized...
August 8, 2018: Journal of Clinical and Experimental Hematopathology: JCEH
https://www.readbyqxmd.com/read/30089749/the-clinical-impact-of-human-t-lymphotrophic-virus-type-1-htlv-1-infection-on-the-development-of-adult-t-cell-leukemia-lymphoma-atl-or-htlv-1-associated-myelopathy-ham-atypical-ham-after-allogeneic-hematopoietic-stem-cell-transplantation-allo-hsct-and-renal
#2
Noriaki Kawano, Shuro Yoshida, Sayaka Kawano, Takuro Kuriyama, Yoshihiro Tahara, Atsushi Toyofuku, Tatsuya Manabe, Atsushi Doi, Soushi Terasaka, Kiyoshi Yamashita, Yuji Ueda, Hidenobu Ochiai, Kousuke Marutsuka, Yoshihisa Yamano, Kazuya Shimoda, Ikuo Kikuchi
Because there are limited clinical reports on the impact of human T-lymphotropic virus type 1 (HTLV-1) on organ transplantation, its effects on the development of adult T-cell leukemia-lymphoma (ATL), post-transplantation lymphoproliferative disorder (PTLD) and HTLV-1-associated myelopathy (HAM) or atypical HAM after organ transplantation remain unclear.We retrospectively analyzed the impact of HTLV-1 in 54 allogeneic hematopoietic stem cell transplantation (allo-HSCT) cases and 31 renal transplantation cases between January 2006 and December 2016...
August 8, 2018: Journal of Clinical and Experimental Hematopathology: JCEH
https://www.readbyqxmd.com/read/30089748/therapy-related-myelodysplastic-syndrome-after-autologous-stem-cell-transplantation-using-plerixafor-for-mobilized-stem-cells-in-a-patient-with-multiple-myeloma
#3
Hiroaki Tanaka, Chihiro Kuwabara, Kensuke Kayamori, Ryo Shimizu, Yoshio Suzuki
No abstract text is available yet for this article.
August 8, 2018: Journal of Clinical and Experimental Hematopathology: JCEH
https://www.readbyqxmd.com/read/30012922/characteristic-histological-findings-of-asymptomatic-ebv-associated-lymphoproliferative-disorders-in-tonsils
#4
Tsengelmaa Jamiyan, Yoshimasa Nakazato, Hajime Kuroda, Masaru Kojima, Yasuo Imai
No abstract text is available yet for this article.
July 14, 2018: Journal of Clinical and Experimental Hematopathology: JCEH
https://www.readbyqxmd.com/read/30012921/a-case-of-chronic-lymphocytic-leukemia-complicated-by-autoimmune-hemolytic-anemia-due-to-ibrutinib-treatment
#5
Takaharu Suzuki, Shukuko Miyakoshi, Ayako Nanba, Takayoshi Uchiyama, Keisuke Kawamoto, Sadao Aoki
Ibrutinib (IBR) covalently binds to the active site of Bruton's tyrosine kinase (BTK) and is used for the treatment of relapsed/refractory chronic lymphocytic leukemia (CLL). Approximately 5-10% of CLL is complicated by autoimmune cytopenia (AIC), such as autoimmune hemolytic anemia (AIHA). Several cases of AIC have reportedly demonstrated improvement during IBR treatment. However, in our case, the patient developed AIHA during oral IBR treatment. As AIHA is exacerbated by the increased number of CLL cells in the peripheral blood, it may have developed because of disease progression rather than IBR use...
July 14, 2018: Journal of Clinical and Experimental Hematopathology: JCEH
https://www.readbyqxmd.com/read/30012920/transformation-of-double-hit-follicular-lymphoma-to-plasmablastic-lymphoma-a-partial-role-of-myc-gene-rearrangement
#6
Mikiko Ise, Hajime Kageyama, Dai Ikebe, Akinobu Araki, Kyoya Kumagai, Makiko Itami
Follicular lymphoma (FL) is genetically characterized by BCL2/IGH translocation. Some FL cases histologically transform to high-grade lymphoma, and the majority of cases transform to diffuse large B-cell lymphoma. We report herein an unusual FL case that transformed to plasmablastic lymphoma (PBL) with MYC gene rearrangement as early as 12 months after FL diagnosis. IGH/MYC translocation, the most common cytogenetic abnormality seen in de novo PBL, was also detected in the transformed tumor (double-hit lymphoma)...
July 14, 2018: Journal of Clinical and Experimental Hematopathology: JCEH
https://www.readbyqxmd.com/read/29657256/colonal-monomorphic-epitheliotropic-intestinal-t-cell-lymphoma-with-novel-phenotype-of-cytoplasmic-cd3-expression
#7
Yumi Aoyama, Hiroko Tsunemine, Yuriko Zushi, Hayato Maruoka, Yuta Goto, Taiichi Kodaka, Tomoo Itoh, Takayuki Takahashi
Monomorphic epitheliotropic intestinal T-cell lymphoma (MEITL) is a new clinical entity that was reclassified from enteropathy-associated T-cell lymphoma in the 2016 WHO classification. An 83-year-old man with fever and diarrhea was referred to our hospital because of free air in the abdominal cavity and wall thickening of the large intestine on CT. Colonofiberscopic examination revealed mucosal edema and multiple ulcers at the sigmoid colon, splenic flexure, and transverse colon. Histopathological examination of the mucosal biopsy specimen demonstrated dense infiltration of small lymphocytes with nuclear atypia, some of which exhibited intraepithelial invasion...
July 11, 2018: Journal of Clinical and Experimental Hematopathology: JCEH
https://www.readbyqxmd.com/read/29657255/genome-wide-sirna-screening-in-mouse-bone-marrow-derived-macrophages-revealed-that-knockdown-of-ribosomal-proteins-suppresses-il-10-and-enhances-tnf-%C3%AE-production
#8
Yoshihiko Okamura, Naoyuki Makita, Yoshiyuki Hizukuri, Yasuhiro Hayashi
Macrophages play a central role in the immune response, and their diverse functions are attributed to the spectrum of their functional states. To elucidate molecules involved in modulating the balance between the anti-inflammatory cytokine IL-10 and the pro-inflammatory cytokine TNF-α, we conducted genome-wide siRNA screening. First, we established an siRNA screening system using mouse bone marrow-derived macrophages, which are a suitable model for studying functional states of macrophages in vitro. In the primary screen and the subsequent reproducibility assay, 112 siRNA pools demonstrated enhancement of IL-10 production and 497 siRNA pools suppressed IL-10 production...
July 11, 2018: Journal of Clinical and Experimental Hematopathology: JCEH
https://www.readbyqxmd.com/read/29415979/autopsy-case-report-of-intravascular-large-b-cell-lymphoma-with-neoplastic-pd-l1-expression
#9
Ayako Sakakibara, Yuichiro Inagaki, Eiki Imaoka, Eri Ishikawa, Satoko Shimada, Kazuyuki Shimada, Yuka Suzuki, Shigeo Nakamura, Akira Satou, Kei Kohno
Intravascular large B-cell lymphoma (IVLBCL) is a rare and clinically distinctive entity characterized by the almost exclusive growth of large cells within the lumen of blood vessels in particular capillaries. Reports of this peculiar disease, do not commonly address the PD-L1 expression on IVLBCL tumor cells. Here, we describe a 51-year-old Japanese woman who presented with rapidly progressive cognitive decline and higher brain dysfunction. CT scan and MRI revealed multiple ischemic foci in the cerebral hemispheres, ground-glass opacity in the lungs, and splenomegaly...
March 16, 2018: Journal of Clinical and Experimental Hematopathology: JCEH
https://www.readbyqxmd.com/read/29415978/hyaline-vascular-castleman-s-disease-representing-18-trisomy
#10
Masaru Kojima, Seiichi Shimizu
No abstract text is available yet for this article.
March 16, 2018: Journal of Clinical and Experimental Hematopathology: JCEH
https://www.readbyqxmd.com/read/29415977/composite-lymphoma-as-co-occurrence-of-advanced-chronic-lymphocytic-leukemia-small-lymphocytic-lymphoma-carrying-trisomy-12-and-t-14-18-and-peripheral-t-cell-lymphoma
#11
Yumi Aoyama, Taiichi Kodaka, Yuriko Zushi, Yuta Goto, Hiroko Tsunemine, Tomoo Itoh, Takayuki Takahashi
Composite lymphoma is defined as the co-occurrence of two types of lymphoma, comprising 1-4% of lymphomas, and the association of B-cell-type chronic lymphocytic leukemia (B-CLL)/small lymphocytic lymphoma and peripheral T-cell lymphoma (PTCL) is rare. Here, we report a case (77-year-old woman) of advanced B-CLL complicated by newly appearing PTCL. Two years after the onset of B-CLL, CLL cells acquired CD38 antigen expression and the disease entity became CLL/prolymphocytic leukemia. Trisomy 12 and t(14;18) karyotypes were observed...
March 16, 2018: Journal of Clinical and Experimental Hematopathology: JCEH
https://www.readbyqxmd.com/read/29415976/clinical-management-and-outcomes-of-completely-resected-stage-i-follicular-lymphoma
#12
MULTICENTER STUDY
Akihiko Yokohama, Yoko Hashimoto, Makiko Takizawa, Hiroaki Shimizu, Yuri Miyazawa, Akio Saitoh, Kohtaro Toyama, Takuma Ishizaki, Takeki Mitsui, Takayuki Saitoh, Kayoko Murayama, Morio Matsumoto, Morio Sawamura, Hirokazu Murakami, Junko Hirato, Masaru Kojima, Yoshihisa Nojima, Hiroshi Handa, Norifumi Tsukamoto
Recent studies have revealed the clinical and biological features of stage I follicular lymphoma (FL), but information about patients with stage I FL who underwent total resection after tissue biopsy is limited. Among 305 FL patients diagnosed between 2001 and 2013, clinical stage I disease was observed in 36 patients. Of these, 18 patients underwent total resection after diagnostic tissue biopsy. We used 18 F-fluorodeoxyglucose positron emission CT for staging assessment in 13 of 18 patients (72.2%). The median age was 56...
March 16, 2018: Journal of Clinical and Experimental Hematopathology: JCEH
https://www.readbyqxmd.com/read/29415975/detection-of-minimal-bone-marrow-involvement-of-blastic-plasmacytoid-dendritic-cell-neoplastic-cells-cd303-immunostaining-as-a-diagnostic-tool
#13
Rintaro Ohe, Naing Ye Aung, Yosuke Shiono, Aya Utsunomiya, Takanobu Kabasawa, Nobuyuki Tamazawa, Yuka Tamura, Tomoya Kato, Akane Yamada, Shin Hasegawa, Keiko Aizawa, Kyoko Inokura, Satoshi Ito, Tomomi Toubai, Yuichi Kato, Takahiko Tsunoda, Kosuke Onami, Tamio Suzuki, Kenichi Ishizawa, Mitsunori Yamakawa
Blastic plasmacytoid dendritic cell (pDC) neoplasm (BPDCN) is a relatively rare hematological malignancy with significantly complex clinicopathological features that are still unclear. This study aimed to analyze the clinicopathological data of BPDCN and evaluate immunohistochemical detection of minimal bone marrow (BM) involvement. In this study, we examined skin and BM lesions from 6 patients with BPDCN. Neoplastic cells tested positive for CD303 (polyclonal, 100%; monoclonal, 40%) in the skin lesions and for CD303 (polyclonal, 100%; monoclonal, 67%) in the BM clots...
March 16, 2018: Journal of Clinical and Experimental Hematopathology: JCEH
https://www.readbyqxmd.com/read/29415974/a-case-of-classical-hodgkin-lymphoma-with-total-lymph-node-infarction
#14
Marika Okuni, Kimikazu Yakushijin, Yasuhiro Sakai, Hirotaka Suto, Hiroya Ichikawa, Rina Sakai, Seiji Kakiuchi, Keiji Kurata, Yu Mizutani, Akihito Kitao, Yoshiharu Miyata, Yasuyuki Saito, Shinichiro Kawamoto, Katsuya Yamamoto, Mitsuhiro Ito, Hiroshi Matsuoka, Hironobu Minami
Lymph node infarction is very rare, and is frequently associated with neoplasms, such as malignant lymphoma and non-neoplastic disease, or interventions such as fine-needle aspiration (FNA). A 76-year-old-man presented with cervical lymph node swelling. Although FNA was performed, the findings were insufficient for a definitive diagnosis. Consequently, surgical biopsy of the cervical lymph node was performed, which revealed total infarction; a diagnosis of classical Hodgkin lymphoma was made later. Both lymphoma itself and FNA may cause total lymph node infarction, which makes diagnosis confusing...
March 16, 2018: Journal of Clinical and Experimental Hematopathology: JCEH
https://www.readbyqxmd.com/read/29998979/the-expression-of-pd-1-ligands-and-ido1-by-macrophage-microglia-in-primary-central-nervous-system-lymphoma
#15
Yuko Miyasato, Yasuo Takashima, Hiroto Takeya, Hiromu Yano, Azusa Hayano, Takenobu Nakagawa, Keishi Makino, Motohiro Takeya, Ryuya Yamanaka, Yoshihiro Komohara
Recent progress in anti-tumor immunotherapy has focused on the significance of the tumor microenvironment in tumor progression and resistance to chemo/radio-therapy. Myeloid cells such as macrophages are predominant stromal components in hematological malignancies. In the present study, we investigated the regulation of programmed death-1 (PD-1) ligand expression in primary central nervous system lymphoma (PCNSL) using PCNSL cell lines and human monocyte-derived macrophages. TK PCNSL cell line-derived soluble factors induced overexpression of PD-1 ligands, indoleamine 2,3-dioxygenase (IDO1), and several other cytokines in macrophages...
2018: Journal of Clinical and Experimental Hematopathology: JCEH
https://www.readbyqxmd.com/read/29998978/the-histopathology-of-bone-marrow-failure-in-children
#16
REVIEW
Hideto Iwafuchi
Bone marrow failure (BMF) is a rare but life-threatening disorder that usually manifests as (pan)cytopenia. BMF can be caused by a variety of diseases, but inherited BMF (IBMF) syndromes are a clinically important cause, especially in children. IBMF syndromes are a heterogeneous group of genetic disorders characterized by BMF, physical abnormalities, and predisposition to malignancy. An accurate diagnosis is critical, as disease-specific management, surveillance, and genetic counselling are required for each patient...
2018: Journal of Clinical and Experimental Hematopathology: JCEH
https://www.readbyqxmd.com/read/29998977/the-histopathology-of-myeloma-in-the-bone-marrow
#17
REVIEW
Masahiko Fujino
Myeloma is characterized by the neoplastic proliferation of monoclonal plasma cells. A diagnosis of myeloma is based on the criteria proposed by the International Myeloma Working Group and the pathological findings.Myeloma cells are classified into four types: mature, immature, pleomorphic, and plasmablastic. There are three patterns in which myeloma infiltrates bone marrow - nodular, interstitial, and diffuse. Dutcher bodies are highly specific to neoplastic myeloma cells. On immunohistochemical staining, the specificity of CD138 is high for plasma cells...
2018: Journal of Clinical and Experimental Hematopathology: JCEH
https://www.readbyqxmd.com/read/29998976/histopathology-in-the-diagnosis-of-high-risk-myelodysplastic-syndromes
#18
Hidekazu Kayano
No abstract text is available yet for this article.
2018: Journal of Clinical and Experimental Hematopathology: JCEH
https://www.readbyqxmd.com/read/29998975/histological-evaluation-of-myeloproliferative-neoplasms
#19
REVIEW
Hideyo Fujiwara
In 2017, the revised World Health Organization was published. Regarding myeloproliferative neoplasms, histological findings of bone marrow biopsy is becoming more important for diagnosis. This article highlights particularly the morphology of megakaryocytes and evaluation of myelofibrosis for pathological diagnosis, and immunohistochemistry which can detect somatic mutation.
2018: Journal of Clinical and Experimental Hematopathology: JCEH
https://www.readbyqxmd.com/read/29998974/highlights-focus-on-bone-marrow-pathology
#20
Masafumi Ito
No abstract text is available yet for this article.
2018: Journal of Clinical and Experimental Hematopathology: JCEH
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