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Technology in Cancer Research & Treatment

Yan Mi, Jin Xu, Xuefeng Tang, Changhao Bian, Hongliang Liu, Qiyu Yang, Junying Tang
We studied the influence of various parameters of high-frequency nanosecond pulse bursts on the strength of rabbit muscle contractions. Ten unipolar high-frequency pulse bursts with various field intensities E (1 kV/cm, 4 kV/cm, and 8 kV/cm), intraburst frequencies f (10 kHz, 100 kHz, and 1 MHz), and intraburst pulse numbers N (1, 10, and 100) were applied using a pair of plate electrodes to the surface skin of the rabbits' biceps femoris, and the acceleration signal of muscle contraction near the electrode was measured using a 3-axis acceleration sensor...
January 1, 2018: Technology in Cancer Research & Treatment
Stine K Frandsen, Julie Gehl
Calcium electroporation is a potential novel anticancer treatment, where high concentrations of calcium are introduced into the cell cytosol by electroporation. This is a method where short, high-voltage pulses induce a transient permeabilization of the cell membrane and thereby allow influx and efflux of ions and molecules. Electroporation is used in combination with chemotherapeutic drugs (electrochemotherapy) as a standard treatment for cutaneous metastases, and electroporation using a higher electric field and number of pulses (irreversible electroporation) is increasingly being used as an anticancer treatment...
January 1, 2018: Technology in Cancer Research & Treatment
Chan Woo Wee, Hyun Joon An, Hyun-Cheol Kang, Hak Jae Kim, Hong-Gyun Wu
INTRODUCTION: To evaluate the intra-/interobserver variability of gross target volumes between delineation based on magnetic resonance imaging and computed tomography in patients simulated for stereotactic body radiotherapy for primary lung cancer and lung metastasis. MATERIALS AND METHODS: Twenty-five patients (27 lesions) who underwent computed tomography and magnetic resonance simulation with the MR-60 Co system (ViewRay) were included in the study. Gross target volumes were delineated on the magnetic resonance imaging (GTVMR ) and computed tomography (GTVCT ) images by 2 radiation oncologists (RO1 and RO2)...
January 1, 2018: Technology in Cancer Research & Treatment
Medhanie Tesfay Gebrekidan, Ramona Erber, Arndt Hartmann, Peter A Fasching, Julius Emons, Mathias W Beckmann, Andreas Braeuer
We used a shifted-excitation Raman difference spectroscopy method for the ex vivo classification of resected and formalin-fixed breast tissue samples as normal (healthy) tissue, fibroadenoma, or invasive carcinoma. We analyzed 8 tissue samples containing invasive carcinoma that were surrounded by normal tissue and 3 tissue samples with fibroadenoma only. We made various measurement sites on various tissue samples, in total 240 measurements for each type of tissue. Although the acquired raw spectra contain enough information to clearly differentiate between normal and tumor (fibroadenoma and invasive carcinoma) tissue, the differentiation between fibroadenoma and invasive carcinoma was possible only after the shifted-excitation Raman difference spectroscopy isolation of pure Raman spectra from the heavily fluorescence interfered raw spectra...
January 1, 2018: Technology in Cancer Research & Treatment
Zilong Yuan, Chithra Kumaran Nair, Stanley H Benedict, Richard K Valicenti, Shyam Rao, Ruben C Fragoso, Cari Wright, Jianfeng Qiu, Yi Rong
This work evaluated a commercial fallback planning workflow designed to provide cross-platform treatment planning and delivery. A total of 27 helical tomotherapy intensity-modulated radiotherapy plans covering 4 anatomical sites were selected, including 7 brain, 5 unilateral head and neck, 5 bilateral head and neck, 5 pelvis, and 5 prostate cases. All helical tomotherapy plans were converted to 7-field/9-field intensity-modulated radiotherapy and volumetric-modulated radiotherapy plans through fallback dose-mimicking algorithm using a 6-MV beam model...
January 1, 2018: Technology in Cancer Research & Treatment
Hui Qiao, Yu-Feng Wang, Wen-Zhen Yuan, Bing-Dong Zhu, Lei Jiang, Quan-Lin Guan
α-Enolase is a significant subunit of enolase and acts as a glycolytic enzyme responsible for catalyzing the conversion of 2-phosphoglycerate to phosphoenolpyruvate in the anaerobic glycolysis pathway. The research about their role is known little in tumor invasion and metastasis. This research analyzed the effect of α-enolase in proliferation and progression of human gastric cancer. The constructed PLKO.1-ENO1 shRNA vector was transfected into 293 T cells and used to infect gastric cancer cells, MKN45, by using lentivirus method...
January 1, 2018: Technology in Cancer Research & Treatment
Ute Probst, Irene Fuhrmann, Lukas Beyer, Philipp Wiggermann
Electroporation is a well-known phenomenon that occurs at the cell membrane when cells are exposed to high-intensity electric pulses. Depending on electric pulse amplitude and number of pulses, applied electroporation can be reversible with membrane permeability recovery or irreversible. Reversible electroporation is used to introduce drugs or genetic material into the cell without affecting cell viability. Electrochemotherapy refers to a combined treatment: electroporation and drug injection to enhance its cytotoxic effect up to 1000-fold for bleomycin...
January 1, 2018: Technology in Cancer Research & Treatment
Leszek Miszczyk, Małgorzata Stąpór-Fudzińska, Marcin Miszczyk, Bogusław Maciejewski, Andrzej Tukiendorf
The aim of this study was to evaluate CyberKnife-based radioablation as a salvage treatment for prostate cancer postirradiation relapses based on a group of patients disqualified from available conventional methods of salvage treatment. Thirty-eight patients were treated with a fraction dose varying from 5.5 to 10 Gy (median 7.35) to a total dose of 18 to 36.25 Gy (median 36.25). In all, 55.3% of patients had androgen deprivation therapy during this time. Nine patients had oligometastases in the salvage time...
January 1, 2018: Technology in Cancer Research & Treatment
Yoshiyuki Shioyama, Hiroshi Onishi, Kenji Takayama, Yukinori Matsuo, Atsuya Takeda, Hideomi Yamashita, Akifumi Miyakawa, Naoya Murakami, Masahiko Aoki, Haruo Matsushita, Yasuo Matsumoto, Yuta Shibamoto
Stereotactic body radiotherapy (SBRT) is widely used as a curative treatment option for stage I non-small-cell lung cancer, but for patients with stage I small-cell lung cancer, the role of stereotactic body radiotherapy is unclear. In this study, we retrospectively analyzed the outcomes of a subset of patients with stage I small-cell lung cancer treated with stereotactic body radiotherapy in the database of the Japanese Radiological Society-Multi-Institutional stereotactic body radiotherapy Study Group. The 43 patients treated with stereotactic body radiotherapy for stage I small-cell lung cancer between 2004 and 2012 at 11 Japanese institutions were studied: median age = 77 years; 32 (74%) males and 11 females; and 80% were medically inoperable...
January 1, 2018: Technology in Cancer Research & Treatment
Haiyuan Shen, Shu Zhou, Yun Lou, Yangjuan Gao, Shouji Cao, Du Wu, Guoqiang Li
OBJECTIVE: We evaluated microwave-assisted liver resection for hepatocellular carcinoma. PATIENTS AND METHODS: We enrolled 79 patients in this study, and microwave ablation was used for liver resection. Patients were randomized to group A (50.6%; n = 40), liver resection without microwave ablation, or group B (49.4%; n = 39), liver resection performed using microwave ablation. Data were analyzed for statistical significance. RESULTS: Of the participants enrolled, 60 were male, and the participant's average age was 59...
January 1, 2018: Technology in Cancer Research & Treatment
Monika Savarin, Ajda Prevc, Matic Rzek, Masa Bosnjak, Ilija Vojvodic, Maja Cemazar, Tomaz Jarm, Gregor Sersa
Vascular-targeted therapies exhibit radiosensitizing effects by remodeling tumor vasculature, thus facilitating the increased oxygenation of the remaining tumor tissue. To examine these phenomena, the effects of antiendoglin gene therapy alone and in combination with irradiation were monitored for 5 consecutive days on a murine mammary adenocarcinoma (TS/A) tumor model growing in a dorsal window chamber. The vascularization of the tumors was assessed by the determination of the tumor vascular area and by measurement of tumor perfusion by using laser Doppler flowmetry to provide insight into intratumoral gene electrotransfer effects...
January 1, 2018: Technology in Cancer Research & Treatment
Tomoki Kimura, Hiroshi Aikata, Yoshiko Doi, Nobuki Imano, Yuki Takeuchi, Ippei Takahashi, Ikuno Nishibuchi, Tsuyoshi Katsuta, Masahiro Kenjo, Yuji Murakami, Kazuo Awai, Kazuaki Chayama, Yasushi Nagata
INTRODUCTION: To compare the efficacy and safety of stereotactic body radiation therapy with or without transcatheter arterial chemoembolization for patients with small hepatocellular carcinoma who were ineligible for resection or ablation therapies. METHODS: A total of 150 patients with 185 hepatocellular carcinoma (≤3 nodules, Child-Turcotte-Pugh class A or B, and no vascular or extrahepatic metastases) were treated with stereotactic body radiation therapy. In principle, transcatheter arterial chemoembolization was combined before stereotactic body radiation therapy (combination group), but some patients were treated with stereotactic body radiation therapy alone...
January 1, 2018: Technology in Cancer Research & Treatment
Yusuf Madendag, Erdem Sahin, Ilknur Col Madendag, Mefkure Eraslan Sahin, Gokhan Acmaz, Hatice Karaman
BACKGROUND: Progesterone-induced blocking factor, which is released from maternal lymphocytes during pregnancy mediates the immune effect of progesterone. According to new reports, it is suggested that proliferating cells, such as human trophoblasts, mesenchymal stem cells, and malignant tumors, can excrete progesterone-induced blocking factor at high ratio to escape from maternal immunity. It is shown in recent studies that progesterone-induced blocking factor is overexpressed in many malignant tumors such as breast, cervical, lymphoma, and leukemia...
January 1, 2018: Technology in Cancer Research & Treatment
Tae Hyun Kim, Woo Jin Lee, Sang Myung Woo, Hyunjung Kim, Eun Sang Oh, Ju Hee Lee, Sung-Sik Han, Sang-Jae Park, Yang-Gun Suh, Sung Ho Moon, Sang Soo Kim, Dae Yong Kim
PURPOSE: To evaluate the clinical effectiveness and feasibility of simultaneous integrated boost-proton beam therapy in patients with localized pancreatic cancer. METHODS: Thirty-seven patients with localized pancreatic cancer underwent simultaneous integrated boost-proton beam therapy, and 8 (21.6%) patients received induction chemotherapy. The internal target volume was obtained by summing the gross tumor volumes in exhalation phase computed tomography images...
January 1, 2018: Technology in Cancer Research & Treatment
Yaxing Zhou, Yong Ji, Honggang Wang, Hai Zhang, Haihua Zhou
Colorectal cancer, one of the most commonly diagnosed and lethal cancers worldwide, is accompanied by the disorders of immune system. However, the underlying mechanism is still not fully understood. In this study, our goal was to determine whether interleukin 33 promotes tumorigenesis and progression of colorectal cancer through increased recruitment of tumor-infiltrating ST2+ regulatory T cells in CT26 tumor-bearing mice. We found that the mRNA or protein levels of interleukin 33, soluble ST2, and membrane ST2 were elevated in the serum of tumor-bearing mice when compared to WT mice...
January 1, 2018: Technology in Cancer Research & Treatment
Jie Yang, Pengzhou Kong, Jian Yang, Zhiwu Jia, Xiaoling Hu, Zianyi Wang, Heyang Cui, Yanghui Bi, Yu Qian, Hongyi Li, Fang Wang, Bin Yang, Ting Yan, Yanchun Ma, Ling Zhang, Caixia Cheng, Bin Song, Yaoping Li, Enwei Xu, Haiyan Liu, Wei Gao, Juan Wang, Yiqian Liu, Yuanfang Zhai, Lu Chang, Yi Wang, Yingchun Zhang, Ruyi Shi, Jing Liu, Qi Wang, Xiaolong Cheng, Yongping Cui
Esophageal squamous cell carcinoma is the sixth most lethal cancer worldwide and the fourth most lethal cancer in China. Tissue-specific transplantation antigen P35B codifies the enzyme GDP-d-mannose-4,6-dehydratase, which participates in the biosynthesis of GDP-l-fucose. GDP-l-fucose is an important substrate involved in the biosynthesis of many glycoproteins. Cancer cells are often accompanied by the changes in glycoprotein structure, which affects the adhesion, invasion, and metastasis of cells. It is not clear whether tissue-specific transplantation antigen P35B has any effect on the development of esophageal squamous cell carcinoma...
January 1, 2018: Technology in Cancer Research & Treatment
Xiuyun Li, Geping Yin, Juan Li, Aifang Wu, Zheng Yuan, Jing Liang, Qinghua Sun
To investigate the association between the susceptibility to cervical cancer and the single nucleotide polymorphisms of 5 tumor necrosis factor-α promoter genes (rs361525, rs1800629, rs1800750, rs1799964, and rs673) in Chinese women. A total of 946 peripheral blood samples were collected from women of Han Ethnicity in Shandong province. Of them, 452 were diagnosed with cervical squamous cell carcinomas. The study also included a control group of 494 healthy women. The targeted single nucleotide polymorphisms were analyzed by TaqMan probe method...
January 1, 2018: Technology in Cancer Research & Treatment
Liting Shi, Yaoyao He, Zilong Yuan, Stanley Benedict, Richard Valicenti, Jianfeng Qiu, Yi Rong
Routine follow-up visits and radiographic imaging are required for outcome evaluation and tumor recurrence monitoring. Yet more personalized surveillance is required in order to sufficiently address the nature of heterogeneity in nonsmall cell lung cancer and possible recurrences upon completion of treatment. Radiomics, an emerging noninvasive technology using medical imaging analysis and data mining methodology, has been adopted to the area of cancer diagnostics in recent years. Its potential application in response assessment for cancer treatment has also drawn considerable attention...
January 1, 2018: Technology in Cancer Research & Treatment
He Xiaoyu, Yin Yiru, Shi Shuisheng, Cheng Keyan, Yan Zixing, Cheng Shanglin, Wang Yuan, Cheng Dongming, Zhang Wangliang, Bai Xudong, Ma Jie
OBJECTIVES: Esophageal squamous cell carcinoma is a highly prevalent cancer withpoor survival rate and prognosis. Increasing evidence suggests an important role for metabolic regulation in treating esophageal squamous cell carcinoma, but the underlying mechanism remains unclear. The pyruvate kinase M2 isoform is a key enzyme in the energy production process, and the upregulation of pyruvate kinase M2 isoform also plays a crucial role in gene transcription and tumorigenesis. The mammalian target of rapamycin pathway regulates an array of cellular functions, including protein synthesis, metabolism, and cell proliferation...
January 1, 2018: Technology in Cancer Research & Treatment
Kristen A McConnell, Tyler Marston, Brianna Elizabeth Zehren, Aziz Lirani, Dennis N Stanley, Aaron Bishop, Richard Crownover, Tony Eng, Zheng Shi, Ying Li, Diana Baacke, Neil Kirby, Karl Rasmussen, Niko Papanikolaou, Alonso N Gutierrez
INTRODUCTION: With the advent of complex treatment techniques like volumetric modulated arc therapy, there has been increasing interest in treatment planning technologies aimed at reducing planning time. One of these such technologies is auto-planning, which is an automated planning module within Pinnacle3 . This study seeks to retrospectively evaluate the dosimetric quality of auto-planning-derived treatment plans as they compare to manual plans for intact prostate, prostate and lymph nodes, and brain treatment sites...
January 1, 2018: Technology in Cancer Research & Treatment
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