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Technology in Cancer Research & Treatment

Helena Cindrič, Bor Kos, Giuseppe Tedesco, Matteo Cadossi, Alessandro Gasbarrini, Damijan Miklavčič
Vertebral column is the most frequent site for bone metastases. It has been demonstrated in previous studies that bone metastases can be efficiently treated by electrochemotherapy. We developed a novel approach to treat spinal metastases, that is, transpedicular approach that combines electrochemotherapy with already established technologies for insertion of fixation screws in spinal surgery. In the transpedicular approach, needle electrodes are inserted into the vertebral body through pedicles and placed around the tumor...
January 1, 2018: Technology in Cancer Research & Treatment
Xiaoyan He, Mayinur Maimaiti, Yan Jiao, Xuegang Meng, Hongyan Li
Sinomenine, a bioactive alkaloid isolated from the traditional Chinese herb Sinomenium acutum, possesses antiinflammatory, antinociceptive, antifibrotic, and antitumorigenic properties. In this work, we sought to explore the biological effects of sinomenine on glioma cells. It was found that sinomenine caused a concentration-dependent inhibition of viability in both U87 and U251 glioma cells. Sinomenine at 16 μmol/L caused 55% to 60% reduction in the proliferation of U87 and U251 cells. Moreover, sinomenine treatment induced a G0/G1 cell cycle arrest and apoptosis...
January 1, 2018: Technology in Cancer Research & Treatment
Xia Wu, Ran Chen, Weiliang Zheng, Hongjie Hu
This study aimed to investigate the clinical response and short-term survival and further explore the comprehensive factors for predicting clinical outcomes in patients with liver cancer treated by drug-eluting beads transarterial chemoembolization . Forty-nine patients with liver cancer who received drug-eluting beads transarterial chemoembolization treatment were consecutively enrolled in this cohort study. Demographic features, medical histories, clinicopathological properties, biochemical indexes, previous treatments, and chemoembolization reagents were recorded...
January 1, 2018: Technology in Cancer Research & Treatment
Chengcheng Zhang, Qing Ji, Yue Yang, Qi Li, Zhongqi Wang
As a kind of nanometric lipidic vesicles, exosomes have been presumed to play a leading role in the regulation of tumor microenvironment through exosomes-mediated transfer of proteins and genetic materials. Tumor-derived exosomes are recognized as a critical determinant of the tumor progression. Intriguingly, some current observations have identified that exosomes are essential for several intercellular exchanges of proteins, messenger RNAs, noncoding RNAs (including long noncoding RNAs and microRNAs) as well as to the process of cancer metastasis and drug resistance...
January 1, 2018: Technology in Cancer Research & Treatment
Chaan S Ng, Wei Wei, Payel Ghosh, Ella Anderson, Delise H Herron, Adam G Chandler
PURPOSE: Evaluate observer variability in computed tomography perfusion measurements in lung tumors and assess the relative contributions of individual factors to overall variability. MATERIALS AND METHODS: Four observers independently delineated tumor and defined arterial input function region of interests (tumor region of interest and arterial input function region of interest) on each of 4 contiguous slice levels of computed tomography perfusion images (arterial input function level), in 12 computed tomography perfusion data sets containing lung tumors (>2...
January 1, 2018: Technology in Cancer Research & Treatment
Xue Jiang, Ting Lei, Man Zhang
OBJECTIVE: To explore the correlation of formyl peptide receptor 1 expression with drug resistance and the functions of formyl peptide receptor 1 in drug-resistant bladder cancer. METHODS: Expression of formyl peptide receptor 1 in T24 and T24/DDP cisplatin-resistant bladder cancer cell lines was tested by quantitative real-time Polymerase Chain Reaction and Western blotting. After incubation of T24/DDP with N-formyl-Met-Leu-Phe, the phosphor proteins were tested by Western blot analysis...
January 1, 2018: Technology in Cancer Research & Treatment
Jie Wu, Zhifang Li, Yong Li, Alex Pettitt, Feifan Zhou
Pancreatic cancer is a malignant tumor model with high mortality. Many patients are ineligible for surgical resection once diagnosed; therefore, it is important to explore more safe and effective treatment options. This study was designed to determine the therapeutic effect of reduced graphene oxide combined with the near-infrared laser in animal pancreatic cancer. The results showed that reduced graphene oxide has strong light absorption ability between 600 and 1100 nm detected by spectrophotometer. Experimental results of different concentrations of reduced graphene oxide solution under 980-nm laser irradiation at different powers showed that the enhancement of the photothermal conversion effect of reduced graphene oxide depends on reduced graphene oxide concentration and light dose...
January 1, 2018: Technology in Cancer Research & Treatment
Ye Han, Emily Oakley, Gal Shafirstein, Yoed Rabin, Levent Burak Kara
Interstitial photodynamic therapy has shown promising results in the treatment of locally advanced head and neck cancer. In this therapy, systemic administration of a light-sensitive drug is followed by insertion of multiple laser fibers to illuminate the tumor and its margins. Image-based pretreatment planning is employed in order to deliver a sufficient light dose to the complex locally advanced head-and-neck cancer anatomy, in order to meet clinical requirements. Unfortunately, the tumor may deform between pretreatment imaging for the purpose of planning and intraoperative imaging when the plan is executed...
January 1, 2018: Technology in Cancer Research & Treatment
Chenjing Zhang, Huiqin Gao, Chao Li, Jiangfeng Tu, Zhihao Chen, Weiwei Su, Xiaoge Geng, Xiaojun Chen, Jingya Wang, Wensheng Pan
OBJECTIVE: Previous studies have shown that the transforming growth factor β1 pathway plays an important role in breast cancer metastasis to the liver. However, the mechanism of this metastasis has not been fully clarified. Cancer stem cells are essential for the initiation and propagation of tumor metastasis. The objective of our current study was to define the role of cancer stem cells in transforming growth factor β1-mediated breast cancer hepatic metastases. METHOD: Hematoxylin and eosin staining was used to assess the formation of breast cancer liver metastases and local invasion...
January 1, 2018: Technology in Cancer Research & Treatment
Xiaoying Zhang, Yinhui Xu, Hongbo Liu, Pan Zhao, Yafang Chen, Zhijie Yue, Zhiqing Zhang, Xiaofang Wang
Mesenchymal stromal cells are proven to be likely induce the angiogenic response in multiple myeloma and thus represent an enticing target for antiangiogenesis therapies for multiple myeloma. Substantial evidence indicates that angiogenesis in multiple myeloma is complex and involves direct production of angiogenic cytokines by abnormal plasma cells and these B-cell neoplasia generated pathophysiology change within the microenvironment. In this study, we demonstrated that mesenchymal stromal cells cultured with U266/Lp-1 under hypoxic conditions resulted in an increased α-smooth muscle actin expression and high productive levels of both hypoxia-inducible factor-2α and integrin-linked kinase proteins...
January 1, 2018: Technology in Cancer Research & Treatment
Akihiro Ito, Mitsuhiko Ohta, Yukinari Kato, Shunko Inada, Toshio Kato, Susumu Nakata, Yasushi Yatabe, Mitsuo Goto, Norio Kaneda, Kenichi Kurita, Hayao Nakanishi, Kenji Yoshida
Podoplanin is distinctively overexpressed in oral squamous cell carcinoma than oral benign neoplasms and plays a crucial role in the pathogenesis and metastasis of oral squamous cell carcinoma but its diagnostic application is quite limited. Here, we report a new near-infrared fluorescence imaging method using an indocyanine green (ICG)-labeled anti-podoplanin antibody and a desktop/a handheld ICG detection device for the visualization of oral squamous cell carcinoma-xenografted tumors in nude mice. Both near-infrared imaging methods using a desktop (in vivo imaging system: IVIS) and a handheld device (photodynamic eye: PDE) successfully detected oral squamous cell carcinoma tumors in nude mice in a podoplanin expression-dependent manner with comparable sensitivity...
January 1, 2018: Technology in Cancer Research & Treatment
Zhi-Min Ye, Shu-Jun Dai, Feng-Qin Yan, Lei Wang, Jun Fang, Zhen-Fu Fu, Yue-Zhen Wang
This study aimed to evaluate both the short- and long-term efficacies of chemoradiotherapy in relation to the treatment of esophageal cancer . This was achieved through the use of dynamic contrast-enhanced magnetic resonance imaging-derived volume transfer constant and diffusion weighted imaging-derived apparent diffusion coefficient . Patients with esophageal cancer were assigned into the sensitive and resistant groups based on respective efficacies in chemoradiotherapy. Dynamic contrast-enhanced magnetic resonance imaging and diffusion weighted imaging were used to measure volume transfer constant and apparent diffusion coefficient, while computed tomography was used to calculate tumor size reduction rate...
January 1, 2018: Technology in Cancer Research & Treatment
Malgorzata Fuksiewicz, Beata Kotowicz, Andrzej Rutkowski, Joanna Achinger-Kawecka, Michal Wagrodzki, Maria M Kowalska
BACKGROUND: Colorectal cancer is one of the most common and significant malignancies in the world. YKL-40 (chitinase-3-like protein 1) is involved in cell proliferation, migration, inflammation, and tissue remodeling; and serum levels of YKL-40 are associated with patient outcome in various cancers. The aim of this study was to assess the potential clinical usage of YKL-40 pretreatment serum levels as a prognostic biomarker in rectal cancer. METHODS: Concentrations of YKL-40 and standard tumor marker-Carcinoembryonic antigen (CEA)-were assessed in serum of 83 patients with rectal cancer without distant metastasis, and association with clinicopathological characteristics and disease-free and overall survival was evaluated...
January 1, 2018: Technology in Cancer Research & Treatment
Selma Rivas-Fuentes, Anjarath Higuera Iglesias, Ana García Trejo, Daniel Yair Chavarría Castro, Norma Inclán Figueroa, Teresa Aguirre Pérez, Renata Báez Saldaña, Patricia Gorocica Rosete
Lung adenocarcinoma represents one of the lung cancer subtypes with major prevalence. Accumulating evidence indicates that the immune system plays an important role in the evolution of the neoplastic process; additionally, several reports suggest that chemotherapy has an immunomodulatory effect. In order to identify the peripheral subpopulations of leukocytes that may change after chemotherapy, we evaluated several peripheral immune subpopulations of monocytes and lymphocytes by multicolor flow cytometry. In addition, we also measured cytokines and growth factors on plasma in order to evaluate the pro-inflammatory context in patients with lung adenocarcinoma after chemotherapy...
January 1, 2018: Technology in Cancer Research & Treatment
Xiaofang Li, Run Tian, Hugh Gao, Feng Yan, Le Ying, Yongkang Yang, Pei Yang, Yan'e Gao
Cervical cancer is the leading cause of death with gynecological malignancies. We aimed to explore the molecular mechanism of carcinogenesis and biomarkers for cervical cancer by integrated bioinformatic analysis. We employed RNA-sequencing details of 254 cervical squamous cell carcinomas and 3 normal samples from The Cancer Genome Atlas. To explore the distinct pathways, messenger RNA expression was submitted to a Gene Set Enrichment Analysis. Kyoto Encyclopedia of Genes and Genomes and protein-protein interaction network analysis of differentially expressed genes were performed...
January 1, 2018: Technology in Cancer Research & Treatment
Pengbo Jia, Guangbing Wei, Cancan Zhou, Qi Gao, Yunhua Wu, Xuejun Sun, Xuqi Li
BACKGROUND: MicroRNAs are involved in hepatocellular carcinoma metastasis, a principal cause of hepatocellular carcinoma-related death in patients worldwide. MiR-212 is a microRNA that has been identified in several types of cancers and is postulated to influence cell signaling and subsequent malignant pathogenesis. Despite emerging reports suggesting that miR-212 plays a significant role in the onset, progression, and migration of these types of malignant tumors, its involvement in the development of hepatocellular carcinoma has not been fully elucidated...
January 1, 2018: Technology in Cancer Research & Treatment
John M Baust, Yoed Rabin, Thomas J Polascik, Kimberly L Santucci, Kristi K Snyder, Robert G Van Buskirk, John G Baust
BACKGROUND: Diverse thermal ablative therapies are currently in use for the treatment of cancer. Commonly applied with the intent to cure, these ablative therapies are providing promising success rates similar to and often exceeding "gold standard" approaches. Cancer-curing prospects may be enhanced by deeper understanding of thermal effects on cancer cells and the hosting tissue, including the molecular mechanisms of cancer cell mutations, which enable resistance to therapy...
January 1, 2018: Technology in Cancer Research & Treatment
Khuloud Bajbouj, Jasmin Shafarin, Mawieh Hamad
Mounting evidence suggest that iron overload enhances cancer growth and metastasis; hence, iron chelation is being increasingly used as part of the treatment regimen in patients with cancer. Now whether iron chelation depletes intracellular iron and/or disrupts intracellular iron homeostasis is yet to be fully addressed. MCF-7 and MDA-MB-231 breast cancer cells treated with increasing concentrations of the iron chelator deferoxamine were assessed for intracellular iron status, the expression of key proteins involved in iron metabolism, cell viability, growth potential, and apoptosis at different time points following treatment...
January 1, 2018: Technology in Cancer Research & Treatment
Garcia-Chagollan Mariel, Carranza-Torres Irma Edith, Carranza-Rosales Pilar, Guzmán-Delgado Nancy Elena, Ramírez-Montoya Humberto, Martínez-Silva María Guadalupe, Mariscal-Ramirez Ignacio, Barrón-Gallardo Carlos Alfredo, Pereira-Suárez Ana Laura, Aguilar-Lemarroy Adriana, Jave-Suárez Luis Felipe
BACKGROUND: Currently, one of the most used strategies for the treatment of newly diagnosed patients with breast cancer is neoadjuvant chemotherapy based on the application of taxanes and anthracyclines. However, despite the high number of patients who develop a complete pathological clinical response, resistance and relapse following this therapy continue to be a clinical challenge. As a component of the innate immune system, the cytotoxic function of Natural Killer (NK) cells plays an important role in the elimination of tumor cells...
January 1, 2018: Technology in Cancer Research & Treatment
Alessia Ongaro, Luca Giovanni Campana, Monica De Mattei, Paolo Di Barba, Fabrizio Dughiero, Michele Forzan, Maria Evelina Mognaschi, Agnese Pellati, Carlo Riccardo Rossi, Clara Bernardello, Elisabetta Sieni
Electrochemotherapy is an emerging local treatment for the management of superficial tumors and, among these, also chest wall recurrences from breast cancer. Generally, the treatment of this peculiar type of tumor requires the coverage of large skin areas. In these cases, electrochemotherapy treatment by means of standard small size needle electrodes (an array of 0.73 cm spaced needles, which covers an area of 1.5 cm2 ) is time-consuming and can allow an inhomogeneous coverage of the target area. We have previously designed grid devices suitable for treating an area ranging from 12 to 200 cm2 ...
January 1, 2018: Technology in Cancer Research & Treatment
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