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Technology in Cancer Research & Treatment

Yoko Satoh, Utaroh Motosugi, Akitoshi Saito, Yoshie Omiya, Hiroshi Onishi
PURPOSE: In this study, we aimed to evaluate the prognostic value of fluorodeoxyglucose uptake in the lung parenchyma and the presence of subclinical interstitial lung disease on computed tomography as predictive factors for survival following stereotactic body radiation therapy in patients with stage I non-small cell lung cancer. METHODS: We retrospectively evaluated 125 patients with stage I non-small cell lung cancer who underwent stereotactic body radiation therapy at our institute between December 2005 and March 2013 for various demographic and clinical parameters...
January 1, 2018: Technology in Cancer Research & Treatment
Shulian Wu, Yudian Huang, Zhifang Li, Huaqing Wu, Hui Li
Dermatofibrosarcoma protuberans is a rare, low-grade skin fibroblastic tumor which tends to recur locally due to its high misdiagnosis. Dermatofibrosarcoma protuberans usually spreads through the intracutaneous and subcutaneous layers into the deep dermis layer in which the main component is collagen. Therefore, alterations in collagen shape and content are important for accurate diagnosis of dermatofibrosarcoma protuberans. In this study, multiphoton microscopy was employed to observe normal human skin and dermatofibrosarcoma protuberans skin...
January 1, 2018: Technology in Cancer Research & Treatment
Muhammad Khan, Jie Lin, Guixiang Liao, Yunhong Tian, Yingying Liang, Rong Li, Mengzhong Liu, Yawei Yuan
Stereotactic radiosurgery provides effective local control, but high recurrence rate are observed while ipilimumab have shown promising improvements in survival in the treatment of melanoma brain metastases. This meta-analysis was done to review the clinical evidence regarding the combination of stereotactic radiosurgery and ipilimumab in the treatment of brain metastases from melanoma. Comprehensive research of the electronic databases (PubMed and Cochrane Library) was carried out in April 2017. Different combination of MESH headings and words were used...
January 1, 2018: Technology in Cancer Research & Treatment
Hu Song, Lingling Liu, Zhaoquan Song, Yongqiang Ren, Chao Li, Jiege Huo
Prolyl 4-hydroxylase alpha subunit is the enzymic active site of prolyl 4-hydroxylase, which is a critical enzyme to maintain the stability of newly synthesized collagens. The expression profile and functional role of P4HA3 in gastric cancer have not been explored. In the Cancer Genome Atlas-Stomach Cancer, P4HA3 RNA is significantly upregulated in gastric cancer than in normal stomach tissues. In the Human Protein Atlas, Prolyl 4-hydroxylase alpha subunit is not detectable by immunohistochemistry staining in normal stomach tissues, but it has weak staining in 7 of 12 gastric cancer tissues...
January 1, 2018: Technology in Cancer Research & Treatment
Yukinori Matsuo
PURPOSE: The purpose of this review article was to summarize available data on the efficacy and safety of salvage radiotherapy for isolated local or regional recurrence after prior stereotactic body radiotherapy for lung cancer. METHODS: Studies were systematically searched on PubMed, following which suitable papers were selected. Reported outcomes and toxicities were qualitatively reviewed. RESULTS: Nineteen papers, which were retrospective studies based on single institution experiences, were selected...
January 1, 2018: Technology in Cancer Research & Treatment
Sicong Jiang, Xi Liu, Daojing Li, Meiying Yan, Cheng Ju, Jun Sun, Feng Jiang
OBJECTIVE: To investigate the role of MAGE family member C2 in angiogenesis and epithelial-mesenchymal transition of non-small cell lung carcinoma. METHODS: The Cancer Genome Atlas data set was analyzed to filter the highly expressed gene melanoma antigen family C2 in non-small cell lung carcinoma. Quantitative reverse transcription-polymerase chain reaction was performed to verify the overexpression of melanoma antigen family C2 in non-small cell lung carcinoma cell lines...
January 1, 2018: Technology in Cancer Research & Treatment
Xiao-Yu Yang, Bin Wu, Sen-Lin Ma, Lei Yin, Meng-Chao Wu, Ai-Jun Li
BACKGROUND: ZW10 interactor was recently reported to correlate with human cancers. However, the prognostic value of ZW10 interactor in hepatocellular carcinoma was not reported. METHODS: The expression level of ZW10 interactor was evaluated by Western blot and immunohistochemistry using tissue microarray. In the present study, we used 5 pairs of hepatocellular carcinoma and peritumoral frozen tissues for Western blot, and 70 paired paraffin-embedded hepatocellular carcinoma and peritumoral tissues as expression pattern cohort (cohort 1), and 280 paraffin-embedded hepatocellular carcinoma tissues were used as prognostic cohort (cohort 2)...
January 1, 2018: Technology in Cancer Research & Treatment
Shuai-Xi Yang, Zhen-Qiang Sun, Quan-Bo Zhou, Ji-Zhong Xu, Yuan Chang, Kun-Kun Xia, Gui-Xian Wang, Zhen Li, Jun-Min Song, Zhi-Yong Zhang, Wei-Tang Yuan, Jin-Bo Liu
PURPOSE: This retrospective study was designed to assess the safety and effectiveness of open, laparoscopic, robotic colorectal cancer surgery. METHODS: Three hundred patients with colorectal cancer who underwent curative resection in the First Affiliated Hospital of Zhengzhou University between February 2014 and May 2016 were included. Patients were classified into open surgery group, laparoscopic surgery group, and robot-assisted group. RESULTS: The blood loss in laparoscopic surgery group was less than that in open surgery group, and the blood loss in robot-assisted group less was than the open surgery group...
January 1, 2018: Technology in Cancer Research & Treatment
Igor Serša, Franci Bajd, Monika Savarin, Tanja Jesenko, Maja Čemažar, Gregor Serša
Hypoxia is a condition, common to most malignant tumors, where oxygen tension in the tissue is below the physiological level. Among consequences of tumor hypoxia is also altered cancer cell metabolism that contributes to cancer therapy resistance. Therefore, precise assessment of tumor hypoxia is important for monitoring the tumor treatment progression. In this study, we propose a simple model for prediction of hypoxic level in tumors based on multiparametric magnetic resonance imaging. The study was performed on B16F1 murine melanoma tumors ex vivo that were first magnetic resonance scanned and then analyzed for hypoxic level using hypoxia-inducable factor 1-alpha antibody staining...
January 1, 2018: Technology in Cancer Research & Treatment
Tao Lin, Shiming Zhou, Hui Gao, Yuqiao Li, Lijiang Sun
PURPOSE: We evaluated whether human microRNA-325 may be a potential biomarker and tumor regulator in bladder cancer. METHODS: Human microRNA-325 expression was probed by quantitative real-time polymerase chain reaction in both in vitro bladder cancer cell lines and in vivo bladder carcinoma tissues retrieved from patients with cancer. The prognostic potential of human microRNA-325 in predicting postoperative overall survival of patients with bladder cancer was estimated...
January 1, 2018: Technology in Cancer Research & Treatment
Biying Yu, Hongqin Yang, Xiaoman Zhang, Hui Li
Heat shock protein 70 has been recognized as a target for anticancer therapy. The overexpression of heat shock protein 70 is observed frequently in several types of tumors, including breast cancer. It is involved with increased cell proliferation, poor prognosis, and drug resistance in breast cancer. VER-155008 is an effective inhibitor of heat shock protein 70 that targets the adenosine triphosphatase-binding domain of heat shock protein 70. In this study, the effects of VER-155008, heat shock (43°C, 1 hour), and the combination treatment of VER-155008 and heat shock on the mitochondria of the MCF-7 breast cancer cells were investigated through a laser scanning microscope combined with mitochondrial membrane potential fluorescence probe...
January 1, 2018: Technology in Cancer Research & Treatment
Chongyu Su, Kang Shi, Xu Cheng, Yi Han, Yunsong Li, Daping Yu, Zhidong Liu
OBJECTIVE: We aimed to detect the role of LINC00472 via regulating miR-24-3p and death effector domain-containing DNA-binding protein in lung adenocarcinoma. METHODS: Long noncoding RNA, microRNA, and messenger RNA levels were determined using reverse transcription quantitative polymerase chain reaction. The expression of death effector domain-containing DNA-binding protein was determined using Western blot assay. 3-(4,5-Dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay and colony formation assay were conducted to explore the proliferation of cells...
January 1, 2018: Technology in Cancer Research & Treatment
Adriana Leticia Vera-Tizatl, Claudia Elizabeth Vera-Tizatl, Arturo Vera-Hernández, Lorenzo Leija-Salas, Sergio Rodríguez, Damijan Miklavčič, Bor Kos
Breast cancer represents a rising problem concerning public health worldwide. Current efforts are aimed to the development of new minimally invasive and conservative treatment procedures for this disease. A treatment approach for invasive breast ductal carcinoma could be based on electroporation. Hence, in order to determine the effectiveness of electrochemotherapy in the treatment of this disease, 12 electrode models were investigated on realistic patient-specific computational breast models of 3 patients diagnosed by Digital Breast Tomosynthesis imaging...
January 1, 2018: Technology in Cancer Research & Treatment
Keiichi Jingu, Haruo Matsushita, Takaya Yamamoto, Rei Umezawa, Yojiro Ishikawa, Noriyoshi Takahashi, Yu Katagiri, Kazuya Takeda, Noriyuki Kadoya
PURPOSE: The purpose of this study was to determine whether pulmonary oligometastases from colorectal cancer have greater radioresistance than that of pulmonary oligometastases from other cancers and whether good local control can be achieved by dose escalation in stereotactic body radiotherapy. MATERIALS AND METHODS: This systematic review and meta-analysis were conducted according to the preferred reporting items for systematic reviews and meta-analyses statement and methods...
January 1, 2018: Technology in Cancer Research & Treatment
Gaowen Chen, Lin Zhu, Yulu Yang, Yusheng Long, Xiangyuan Li, Yifeng Wang
OBJECTIVE: The aim of the study was to investigate the prognostic role of neutrophil to lymphocyte ratio in ovarian cancer. Growing number of articles reported the relationship between neutrophil to lymphocyte ratio and prognosis in ovarian cancer, but the results remains inconclusive. The meta-analysis was conducted to analyze the association of pretreatment neutrophil to lymphocyte ratio with overall survival and progression-free survival. METHODS: We performed a systematic literature research of PubMed, EMBASE, Medline, and Cochrane library for relevant studies up to October 8, 2017...
January 1, 2018: Technology in Cancer Research & Treatment
Xue-Fang Liu, Khaing Zar Thin, Xin-Liang Ming, Shuo-Li, Ping-Luo, Man-Zhu, Nan-Di Li, Jian-Cheng Tu
BACKGROUND: Noncoding RNAs are crucial regulators acting as either tumor suppressor genes or oncogenes in human cancer progression. The aberrant expression of noncoding RNAs has been confirmed in different kinds of cancers. Hepatocellular carcinoma is one of the most common malignant tumors worldwide, characterized by insidious onset, great malignancy, and high rates of recurrence and metastasis. Due to lack of early predictive markers, numerous patients are diagnosed in the late stages...
January 1, 2018: Technology in Cancer Research & Treatment
Ruyi Huang, Yiyao Cui, Yujiang Guo
Radiotherapy is the most important component of the comprehensive treatment of breast cancer, and immunocompromised patients respond with lower response rate. However, the role of programmed cell death protein-1, a critical immune molecule, in recurrence of breast cancer subjected to radiotherapy is unknown. A retrospective analysis was designed to explore the relevance. A number of 42 patients with early-stage breast cancer undergoing breast-conserving surgery and postoperative radiotherapy (18 recurrence and 24 nonrecurrence) were recruited, and clinical data were obtained...
January 1, 2018: Technology in Cancer Research & Treatment
Zhimin Fu, Xiaocheng Cao, Yi Yang, Zhenwei Song, Jiansong Zhang, Zheng Wang
Manganese superoxide dismutase promotes migration and invasion in lung cancer cells via upregulation of the transcription factor forkhead box M1. Here, we assessed whether upregulation of forkhead box M1 by manganese superoxide dismutase overexpression mediates the acquisition of cancer stem-like cell characteristics in non-small cell lung cancer H460 cells. The second-generation spheroids from H460 cells were used as lung cancer stem-like cells. The levels of manganese superoxide dismutase, forkhead box M1, stemness markers (CD133, CD44, and ALDH1), and transcription factors (Bmi1, Nanog, and Sox2) were analyzed by Western blot...
January 1, 2018: Technology in Cancer Research & Treatment
Ibrahim Fahoum, Relly Forer, Dina Volodarsky, Inna Vulih, Tova Bick, Shada Sarji, Zeev Bamberger, Ofer Ben-Izhak, Edmond Sabo, Ruth Hershberg, Dov Hershkovitz
OBJECTIVE: Circulating tumor DNA is a promising noninvasive tool for cancer monitoring. One of the challenges in applying this tool is the detection of low-frequency mutations. The detection limit of these mutations varies between different molecular methods. The aim of this study is to characterize the factors affecting the limit of detection for epidermal growth factor receptor p.T790M mutation in circulating tumor DNA of patients with lung adenocarcinoma. METHODS: DNA was extracted from plasma samples of 102 patients...
January 1, 2018: Technology in Cancer Research & Treatment
Olivier Sutter, Amina Fihri, Rafik Ourabia-Belkacem, Nicolas Sellier, Abou Diallo, Olivier Seror
Three-dimensional virtual target fluoroscopic display is a new guidance tool that can facilitate challenging percutaneous ablation. The purpose of this study was to assess the feasibility, local efficacy, and safety of liver ablation assisted by three-dimensional virtual target fluoroscopic display. Sixty-seven hepatocellular carcinomas (mean diameter: 31 mm, range: 9-90 mm, 24 ≥ 30 mm, 16 of an infiltrative form) in 53 consecutive patients were ablated using irreversible electroporation (n = 39), multibipolar radiofrequency (n = 25), or microwave (n = 3) under a combination of ultrasound and three-dimensional virtual target fluoroscopic display guidance because the procedures were considered to be unfeasible under ultrasound alone...
January 1, 2018: Technology in Cancer Research & Treatment
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