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Technology in Cancer Research & Treatment

Jun Li, Wenyin Shi, David Andrews, Maria Werner-Wasik, Bo Lu, Yan Yu, Adam Dicker, Haisong Liu
PURPOSE: The study was aimed to compare online 6 degree-of-freedom image registrations of TrueBeam cone-beam computed tomography and BrainLab ExacTrac X-ray imaging systems for intracranial radiosurgery. METHODS: Phantom and patient studies were performed on a Varian TrueBeam STx linear accelerator (version 2.5), which is integrated with a BrainLab ExacTrac imaging system (version 6.1.1). The phantom study was based on a Rando head phantom and was designed to evaluate isocenter location dependence of the image registrations...
June 2017: Technology in Cancer Research & Treatment
Sukran Ulger, Eren Cetin, Serap Catli, Hilal Sarac, Diclehan Kilic, Huseyin Bora
PURPOSE: To investigate high conformality on target coverage and the ability on creating strict lung dose limitation of intensity-modulated radiation therapy in malignant pleural mesothelioma. PATIENTS AND METHODS: Twenty-four radiation therapy plannings were evaluated and compared with dosimetric outcomes of conformal radiation therapy and intensity-modulated radiation therapy. Hemithoracal radiation therapy was performed on 12 patients with a fraction of 1.8 Gy to a total dose of 50...
June 2017: Technology in Cancer Research & Treatment
Rosario Mazzola, Francesco Ricchetti, Alba Fiorentino, Niccolò Giaj Levra, Sergio Fersino, Gioacchino Di Paola, Ruggero Ruggieri, Filippo Alongi
BACKGROUND: To evaluate the feasibility and clinical preliminary results of weekly cisplatin and volumetric-modulated arc therapy to the pelvis with simultaneous integrated boost to macroscopic disease in a cohort of elderly patients. MATERIALS AND METHODS: Inclusion criteria of this prospective study were age ≥70 years, Karnofsky performance status 70 to 100, locally advanced histologically proven squamous cervical carcinoma, and patients unable to undergo brachytherapy...
June 2017: Technology in Cancer Research & Treatment
Tiziana Comito, L Cozzi, E Clerici, C Franzese, A Tozzi, C Iftode, P Navarria, G D'Agostino, L Rimassa, C Carnaghi, N Personeni, M C Tronconi, F De Rose, D Franceschini, A M Ascolese, A Fogliata, S Tomatis, A Santoro, A Zerbi, M Scorsetti
PURPOSE: To assess the efficacy of stereotactic body radiotherapy in patients with unresectable locally advanced pancreatic cancer. MATERIALS AND METHODS: All patients received a prescription dose of 45 Gy in 6 fractions. Primary end point was freedom from local progression. Secondary end points were overall survival, progression-free survival, and toxicity. Actuarial survival analysis and univariate or multivariate analysis were investigated. RESULTS: Forty-five patients were enrolled in a phase 2 trial...
June 2017: Technology in Cancer Research & Treatment
Edward W Jung, David L Jung, Ehsan H Balagamwala, Lilyana Angelov, John H Suh, Toufik Djemil, Anthony Magnelli, Samuel T Chao
PURPOSE: Chordoma is a radioresistant tumor that presents a therapeutic challenge with spine involvement, as high doses of radiation are needed for local control while limiting dose to the spinal cord. The purpose of this study is to determine the efficacy and safety of single-fraction spine stereotactic body radiation therapy for the treatment of spine chordoma. METHODS: A retrospective review of our institutional database from 2006 to 2013 identified 8 patients (12 cases) with chordoma of the spine who were treated with spine stereotactic body radiation therapy...
June 2017: Technology in Cancer Research & Treatment
Mirko D'Onofrio, Stefano Crosara, Riccardo De Robertis, Giovanni Butturini, Roberto Salvia, Salvatore Paiella, Claudio Bassi, Roberto Pozzi Mucelli
AIM: The objective of this study was to evaluate the efficacy of percutaneous radiofrequency ablation of locally advanced pancreatic cancer located in the pancreatic body. MATERIALS AND METHODS: Patients with biopsy-proven locally advanced pancreatic adenocarcinoma were considered for percutaneous radiofrequency ablation. Postprocedural computed tomography studies and Ca19.9 tumor marker evaluation were performed at 24 hours and 1 month. At computed tomography, treatment effect was evaluated by excluding the presence of complications...
June 2017: Technology in Cancer Research & Treatment
Jacob A Miller, Ehsan H Balagamwala, Lilyana Angelov, John H Suh, Toufik Djemil, Anthony Magnelli, Peng Qi, Tingliang Zhuang, Andrew Godley, Samuel T Chao
PURPOSE: Despite advancements in local and systemic therapy, metastasis remains common in the natural history of sarcomas. Unfortunately, such metastases are the most significant source of morbidity and mortality in this heterogeneous disease. As a classically radioresistant histology, stereotactic radiosurgery has emerged to control spinal sarcomas and provide palliation. However, there is a lack of data regarding pain relief and relapse following stereotactic radiosurgery. METHODS: We queried a retrospective institutional database of patients who underwent spine stereotactic radiosurgery for primary and metastatic sarcomas...
June 2017: Technology in Cancer Research & Treatment
Dilini S Pinnaduwage, Martina Descovich, Michael W Lometti, Badri Varad, Mack Roach, Alexander R Gottschalk
This study compares conventional and robotic intensity modulated radiation therapy (IMRT) plans for prostate boost treatments and provides clinical insight into the strengths and weaknesses of each. The potential for dose escalation with robotic IMRT is further investigated using the "critical volume tolerance" method proposed by Roach et al. Three clinically acceptable treatment plans were generated for 10 prostate boost patients: (1) a robotic IMRT plan using fixed cones, (2) a robotic IMRT plan using the Iris variable aperture collimator, and (3) a conventional linac based IMRT (c-IMRT) plan...
June 2017: Technology in Cancer Research & Treatment
Qiyong Fan, Anamaria R Yeung, Robert Amdur, Richard Helmig, Justin Park, Jonathan Li, Darren Kahler, Chihray Liu, Bo Lu
PURPOSE: The efficacy of image-guided high-dose rate brachytherapy for cervical cancer is limited by the ineffective rectal sparing devices available commercially and the potential applicator movement. We developed a novel device using a balloon catheter and a belt immobilization system, serving for rectal dose reduction and applicator immobilization purposes, respectively. METHODS: The balloon catheter is constructed by gluing a short inflatable tube to a long regular open-end catheter...
June 2017: Technology in Cancer Research & Treatment
Jan Seppälä, Sami Suilamo, Mikko Tenhunen, Liisa Sailas, Heli Virsunen, Erna Kaleva, Jani Keyriläinen
PURPOSE: The aim of this study was to compare dosimetric characteristics, monitor unit, and delivery efficiency of 4 different stereotactic body radiotherapy techniques for the treatment of prostate cancer. METHODS: This study included 8 patients with localized prostate cancer. Dosimetric assets of 4 delivery techniques for stereotactic body radiotherapy were evaluated: robotic CyberKnife, noncoplanar intensity-modulated radiotherapy, and 2 intensity-modulated arc therapy techniques (RapidArc and Elekta volumetric-modulated arc therapy)...
April 2017: Technology in Cancer Research & Treatment
Joe H Chang, Arnjeet Sangha, Derek Hyde, Hany Soliman, Sten Myrehaug, Mark Ruschin, Young Lee, Arjun Sahgal, Renee Korol
The aim of this study is to determine whether stereotactic body radiotherapy for multiple vertebral metastases treated with a single isocenter results in greater intrafraction errors than stereotactic body radiotherapy for single vertebral metastases and to determine whether the currently used spinal cord planning organ at risk volume and planning target volume margins are appropriate. Intrafraction errors were assessed for 65 stereotactic body radiotherapy treatments for vertebral metastases. Cone beam computed tomography images were acquired before, during, and after treatment for each fraction...
April 2017: Technology in Cancer Research & Treatment
Jiatong Li, Feifan Xiao, Yuening Zhang, Aihua Lan, Qian Song, Ruoheng Zhang, Kailong Gu, Ping Chen, Zhuo Li, Xinhua Zhang, Xiaoli Yang
The association between the polymorphic GGN repeat in androgen receptor gene and prostate cancer susceptibility has been studied extensively. But the results of these polymorphisms with prostate cancer risk remain inconclusive. Previous meta-analysis showed short GGN repeats (≤16 repeats) had high risks for prostate cancer compared with longer GGN repeats (>16 repeats). Many studies have been published since the release of the previous meta-analysis. Here, we conducted an updated meta-analysis to demonstrate whether short repeats have higher risks for prostate cancer compared to long repeats...
April 2017: Technology in Cancer Research & Treatment
Wenjuan Chen, Penggang Bai, Jianji Pan, Yuanji Xu, Kaiqiang Chen
PURPOSE: To assess changes in the volumes and spatial locations of tumors and surrounding organs by cone beam computed tomography during treatment for cervical cancer. MATERIALS AND METHODS: Sixteen patients with cervical cancer had intensity-modulated radiotherapy and off-line cone beam computed tomography during chemotherapy and/or radiation therapy. The gross tumor volume (GTV-T) and clinical target volumes (CTVs) were contoured on the planning computed tomography and weekly cone beam computed tomography image, and changes in volumes and spatial locations were evaluated using the volume difference method and Dice similarity coefficients...
April 2017: Technology in Cancer Research & Treatment
Scott R Silva, Murat Surucu, Jennifer Steber, Matthew M Harkenrider, Mehee Choi
OBJECTIVE: Radiation treatment planning for locally advanced lung cancer can be technically challenging, as delivery of ≥60 Gy to large volumes with concurrent chemotherapy is often associated with significant risk of normal tissue toxicity. We clinically implemented a novel hybrid RapidArc technique in patients with lung cancer and compared these plans with 3-dimensional conformal radiotherapy and RapidArc-only plans. MATERIALS/METHODS: Hybrid RapidArc was used to treat 11 patients with locally advanced lung cancer having bulky mediastinal adenopathy...
April 2017: Technology in Cancer Research & Treatment
Mei Cao, Panpan Qi, Chong Chen, Liju Song, Xuege Wang, Ningzhe Li, Daoyan Wu, Guoku Hu, Jian Zhao
Aurora kinase B, playing a vital, important role in mitosis, is frequently detected to be overexpressed in many cancer cell lines and various tumor tissues, including prostatic carcinoma. Given the essential function of Aurora kinase B in mitosis and its association with tumorigenesis, it might be a drug target for prostatic carcinoma treatment. In our study, short hairpin RNA targeting Aurora kinase B was cloned into a pGPU6 plasmid vector and then transfected into human prostatic carcinoma cells. The expression level of Aurora kinase B was verified by reverse transcription-polymerase chain reaction and Western blot...
February 2017: Technology in Cancer Research & Treatment
Reza Agheli, Bijan Emkanian, Raheleh Halabian, Jalil Fallah Mehrabadi, Abbas Ali Imani Fooladi
BACKGROUND: About 20 different types of staphylococcal enterotoxins are produced by Staphylococcus aureus, in which type A is more common in food poisoning syndrome. Also staphylococcal enterotoxin A superantigen is a potent inducer of cytotoxic T lymphocyte activity and cytokine production and could stimulate T cells containing T-cell receptor beta chain domains when binding to major histocompatibility complex class II molecules. Hence, it is an important reagent in cancer immunotherapy...
February 2017: Technology in Cancer Research & Treatment
Jianying Zeng, Guifeng Liu, Zhong-Hai Li, Yi Yang, Gang Fang, Rong-Rong Li, Ke-Cheng Xu, Lizhi Niu
This study aimed to investigate the safety and effectiveness of irreversible electroporation ablation for unresectable large liver cancer. Fourteen patients were enrolled: 8 with large hepatocellular carcinoma (tumor diameter: 5.1-11.5 cm) and 6 with medium hepatocellular carcinoma (tumor diameter: 3.0-4.1 cm). All patients received percutaneous irreversible electroporation ablation. Ablation time and the incidence of complications were assessed by a t test. Post-irreversible electroporation and regular contrast-enhanced computerized tomography scans were performed to investigate the effect of tumor size (large vs medium) on irreversible electroporation treatment efficacy; 4-table data were assessed using a Fisher exact test...
February 2017: Technology in Cancer Research & Treatment
Qing-Qing Ma, Jian-Ting Huang, Yun-Gang Xiong, Xiao-Yan Yang, Ran Han, Wang-Wen Zhu
Glioblastoma multiforme, the most common and aggressive form of primary brain tumor, presents a dismal prognosis. MicroRNAs play a critical role in the initiation, progression, and metastasis of cancer; however, the potential biological role of miRNAs in glioblastoma multiforme remains largely unknown. In our study, we found that microRNA-96 is upregulated in glioma tissues than in normal human brains. Transfection of microRNA-96 mimics into glioma cells significantly decreases apoptosis by suppressing PDCD4, a well-known tumor suppressor that is involved in apoptosis...
February 2017: Technology in Cancer Research & Treatment
Hong Zhang, Vic Kong, Ke Huang, Jian-Yue Jin
PURPOSE: To present our experiences in understanding and minimizing bowtie-filter crescent artifacts and bowtie-filter normalization artifacts in a clinical cone beam computed tomography system. METHODS: Bowtie-filter position and profile variations during gantry rotation were studied. Two previously proposed strategies (A and B) were applied to the clinical cone beam computed tomography system to correct bowtie-filter crescent artifacts. Physical calibration and analytical approaches were used to minimize the norm phantom misalignment and to correct for bowtie-filter normalization artifacts...
February 2017: Technology in Cancer Research & Treatment
Jinbo Ma, Zhaoyang Wang, Chengde Wang, Ercheng Chen, Yaozong Dong, Yipeng Song, Wei Wang, Dong You, Wei Jiang, Rukun Zang
BACKGROUND: To determine whether individualized radiation dose escalation after planned chemoradiation based on the decrease in tumor and normal tissue constraints can improve survival in patients with esophageal carcinoma. METHODS: From August 2005 to December 2010, 112 patients with squamous esophageal carcinoma were treated with radical concurrent chemoradiation. Patients received positron emission tomography-computer tomography scan twice, before radiation and after radiation dose of 50...
February 2017: Technology in Cancer Research & Treatment
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