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Technology in Cancer Research & Treatment

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https://www.readbyqxmd.com/read/27884943/recombinant-staphylococcal-enterotoxin-type-a-stimulate-antitumoral-cytokines
#1
Reza Agheli, Bijan Emkanian, Raheleh Halabian, Jalil Fallah Mehrabadi, Abbas Ali Imani Fooladi
BACKGROUND: About 20 different types of staphylococcal enterotoxins are produced by Staphylococcus aureus, in which type A is more common in food poisoning syndrome. Also staphylococcal enterotoxin A superantigen is a potent inducer of cytotoxic T lymphocyte activity and cytokine production and could stimulate T cells containing T-cell receptor beta chain domains when binding to major histocompatibility complex class II molecules. Hence, it is an important reagent in cancer immunotherapy...
November 23, 2016: Technology in Cancer Research & Treatment
https://www.readbyqxmd.com/read/27837054/the-safety-and-efficacy-of-irreversible-electroporation-for-large-hepatocellular-carcinoma
#2
Jianying Zeng, Guifeng Liu, Zhong-Hai Li, Yi Yang, Gang Fang, Rong-Rong Li, Ke-Cheng Xu, Lizhi Niu
This study aimed to investigate the safety and effectiveness of irreversible electroporation ablation for unresectable large liver cancer. Fourteen patients were enrolled: 8 with large hepatocellular carcinoma (tumor diameter: 5.1-11.5 cm) and 6 with medium hepatocellular carcinoma (tumor diameter: 3.0-4.1 cm). All patients received percutaneous irreversible electroporation ablation. Ablation time and the incidence of complications were assessed by a t test. Post-irreversible electroporation and regular contrast-enhanced computerized tomography scans were performed to investigate the effect of tumor size (large vs medium) on irreversible electroporation treatment efficacy; 4-table data were assessed using a Fisher exact test...
November 11, 2016: Technology in Cancer Research & Treatment
https://www.readbyqxmd.com/read/27777338/association-between-the-il-6-rs1800795-polymorphism-and-the-risk-of-cervical-cancer-a-meta-analysis-of-1210-cases-and-1525-controls
#3
Haiping Liu, Dan Lyu, Yan Zhang, Lianbing Sheng, Ning Tang
Cervical cancer is the second most common cancer and the third leading cause of cancer-related death among females in less developed countries. Studies have shown that the single-nucleotide polymorphisms of interleukin 6 might be associated with cervical cancer risk. A total of 710 articles from EMBASE, EBSCO, Web of science, PubMed, Springer link, and Chinese National Knowledge Infrastructure databases were reviewed in our study. A meta-analysis on the associations between interleukin 6 rs1800795 polymorphism and cervical cancer risk was carried out by comparison using 5 genetic models...
October 24, 2016: Technology in Cancer Research & Treatment
https://www.readbyqxmd.com/read/27760866/serum-trefoil-factor-3-as-a-protein-biomarker-for-the-diagnosis-of-colorectal-cancer
#4
Qiang Li, Keke Wang, Chang Su, Jieyu Fang
Colorectal cancer is one of the most frequent causes of cancer-related deaths worldwide. Thus, there is a need for timely diagnosis and effective treatment. Our aim in the present study was to detect the serum level of trefoil factor 3 protein and evaluate the diagnostic accuracy of trefoil factor 3 in patients with colorectal cancer. We collected serum samples from 204 participants (127 patients with colorectal cancer, 35 patients with polyps, and 42 healthy controls). The levels of serum trefoil factor 3 and carcinoembryonic antigen expression were measured by enzyme-linked immunosorbent assay...
October 19, 2016: Technology in Cancer Research & Treatment
https://www.readbyqxmd.com/read/27708117/deflection-analysis-of-different-needle-designs-for-prostate-biopsy-and-focal-therapy
#5
Nelson N Stone, Vladimir Mouraviev, David Schechter, Josh Goetz, M Scott Lucia, E Erin Smith, E David Crawford
OBJECTIVE: The biopsy needles currently used were designed for a transrectal biopsy and are known to experience significant deflection from the point of entry into the gland to the needle tip. METHODS: Five designs were selected for testing: 18-gauge Bard, 15-gauge lancet tip needle with 12° vet-point cannula, and trocar tip needle with 12°, 15°, and 20° vet-point cannulas. The 15-gauge needle was designed to take a variable specimen sample between 20 and 60 mm, whereas the Bard needle specimen bed was fixed at 20 mm...
October 5, 2016: Technology in Cancer Research & Treatment
https://www.readbyqxmd.com/read/27688262/the-prognostic-effect-of-mac30-expression-on-patients-with-non-small-cell-lung-cancer-receiving-adjuvant-chemotherapy
#6
Hui Ding, Xianhua Gui, Xubo Lin, Ruhua Chen, Tieliang Ma, Yunlu Sheng, Hourong Cai, Yan Fen
The purpose of this study was to examine the MAC30 expression in non-small cell lung cancer and to evaluate its prognostic value on therapeutic response in patients with non-small cell lung cancer receiving postoperative chemotherapy. Among a total of 218 retrospective Chinese patients with non-small cell lung cancer, 164 patients receiving adjuvant chemotherapy were enrolled in this study. Real-time polymerase chain reaction was performed to confirm the expression of MAC30 messenger RNA in 32 cases of non-small cell lung cancer tumors with the corresponding nontumor lung tissues...
September 29, 2016: Technology in Cancer Research & Treatment
https://www.readbyqxmd.com/read/27680023/clinical-application-of-a-hybrid-rapidarc-radiotherapy-technique-for-locally-advanced-lung-cancer
#7
Scott R Silva, Murat Surucu, Jennifer Steber, Matthew M Harkenrider, Mehee Choi
OBJECTIVE: Radiation treatment planning for locally advanced lung cancer can be technically challenging, as delivery of ≥60 Gy to large volumes with concurrent chemotherapy is often associated with significant risk of normal tissue toxicity. We clinically implemented a novel hybrid RapidArc technique in patients with lung cancer and compared these plans with 3-dimensional conformal radiotherapy and RapidArc-only plans. MATERIALS/METHODS: Hybrid RapidArc was used to treat 11 patients with locally advanced lung cancer having bulky mediastinal adenopathy...
September 28, 2016: Technology in Cancer Research & Treatment
https://www.readbyqxmd.com/read/26744308/mir-125b-functions-as-a-tumor-suppressor-and-enhances-chemosensitivity-to-cisplatin-in-osteosarcoma
#8
Fei Wang, Dapeng Yu, Zhen Liu, Ruijie Wang, Yan Xu, Haiyin Cui, Tingbao Zhao
MicroRNAs are highly conserved noncoding RNA that negatively modulate protein expression at a posttranscriptional and/or translational level and are deeply involved in the pathogenesis of several types of cancers. To date, the potential microRNAs regulating the growth and progression of osteosarcoma are not fully identified yet. Previous reports have shown differentially expressed miR-125b in osteosarcoma. However, the role of miR-125b in human osteosarcoma has not been totally illuminated. In this study, we have shown that miR-125b was downregulated in human osteosarcoma tissues compared to the adjacent tissues and effects as a tumor suppressor in vitro We found that stable overexpression of miR-125b in osteosarcoma cell lines U2OS and MG-63 inhibited cell proliferation, migration, and invasion...
December 2016: Technology in Cancer Research & Treatment
https://www.readbyqxmd.com/read/26682769/dosimetric-performance-of-newly-developed-farmer-type-ionization-chamber-in-radiotherapy-practice
#9
Sathiyan Saminathan, Henry Finlay Godson, Retna Ponmalar, Ravikumar Manickam, James Mazarello, Rahul Fernandes
Dose measurement with ionization chamber is essential to deliver accurate dose to the tumor in radiotherapy. The cylindrical Farmer-type ionization chamber is recommended by various dosimetry protocols for dose measurement of radiotherapy beams. The air-equivalent graphite wall Farmer-type ionization chamber (FAR 65 GB) of active volume 0.65 cm(3) with aluminum as the central electrode material was fabricated. Various dosimetric parameters were studied for the newly developed ionization chamber in cobalt-60, 6 and 18 MV photon beams...
December 2016: Technology in Cancer Research & Treatment
https://www.readbyqxmd.com/read/26655145/time-resolved-versus-integrated-transit-planar-dosimetry-for-volumetric-modulated-arc-therapy-patient-specific-dose-differences-during-treatment-a-proof-of-principle
#10
L C G G Persoon, M Podesta, S M J J G Nijsten, E G C Troost, F Verhaegen
PURPOSE: It is desirable that dosimetric deviations during radiation treatments are detected. Integrated transit planar dosimetry is commonly used to evaluate external beam treatments such as volumetric-modulated arc therapy. This work focuses on patient geometry changes which result in differences between the planned and the delivered radiation dose. Integrated transit planar dosimetry will average out some deviations. Novel time-resolved transit planar dosimetry compares the delivered dose of volumetric-modulated arc therapy to the planned dose at various time points...
December 2016: Technology in Cancer Research & Treatment
https://www.readbyqxmd.com/read/26647409/hif-1%C3%AE-inhibition-sensitized-pituitary-adenoma-cells-to-temozolomide-by-regulating-presenilin-1-expression-and-autophagy
#11
Zhang Kun, Yang Yuling, Wang Dongchun, Xie Bingbing, Li Xiaoli, Xu Bin
Pituitary adenomas usually develop temozolomide resistance, which could compromise the anticancer effects of temozolomide. Suppression of hypoxia-inducible factor 1α has been shown to sensitize glioblastoma cells to temozolomide treatment according to previous reports. However, whether and how the suppression of hypoxia-inducible factor 1α could sensitize pituitary adenomas to temozolomide treatment are still poorly understood. In the present study, using hypoxia-inducible factor 1α knockdown strategy, we demonstrated for the first time that hypoxia-inducible factor 1α knockdown could inhibit temozolomide-induced autophagy in rat pituitary adenoma GH3 cells and thus increase antitumor efficacy of temozolomide...
December 2016: Technology in Cancer Research & Treatment
https://www.readbyqxmd.com/read/26637476/expression-of-annexin-a2-and-its-correlation-with-drug-resistance-and-recurrence-of-bladder-cancer
#12
Huihui Hu, Jin Zhao, Man Zhang
OBJECTIVE: To explore the expressions of annexin A2 in bladder cancer cell lines and bladder cancer tissues, we want to find the relationship among annexin A2, drug resistance, and recurrence of bladder cancer. METHODS: Our laboratory established the PUMC-91 bladder cancer cell line against gradient concentration of Adriamycin (0.3, 0.6, and 1.0 μg/mL), and we also collected 60 cases of surgically resected bladder cancer recurrent tissue samples. The tissues were classified into 2 groups according to the frequency of recurrence (<6 months and >2 years) after initial surgery...
December 2016: Technology in Cancer Research & Treatment
https://www.readbyqxmd.com/read/26614780/metal-artifact-reduction-in-cone-beam-computed-tomography-for-head-and-neck-radiotherapy
#13
Mark Korpics, Paul Johnson, Rakesh Patel, Murat Surucu, Mehee Choi, Bahman Emami, John C Roeske
PURPOSE: To evaluate a method for reducing metal artifacts, arising from dental fillings, on cone-beam computed tomography images. MATERIALS AND METHODS: A projection interpolation algorithm is applied to cone-beam computed tomography images containing metal artifacts from dental fillings. This technique involves identifying metal regions in individual cone-beam computed tomography projections and interpolating the surrounding values to remove the metal from the projection data...
December 2016: Technology in Cancer Research & Treatment
https://www.readbyqxmd.com/read/26614779/gstm1-gene-polymorphism-is-implicated-in-increased-susceptibility-to-prostate-cancer-in-caucasians-and-asians
#14
Zhong-Yang Wang, Hong-Yan Li, Zongpei Jiang, Tian-Biao Zhou, Gregor P C Drummen
Published reports on the relationship between GSTM1 gene polymorphisms and prostate cancer risk are heterogeneous in their conclusions, and the significance of these polymorphisms is still debated. This meta-analysis was performed to attempt to combine comparable studies, thereby increasing sample size and statistical significance in order to obtain a better evaluation of the association between GSTM1 polymorphisms and prostate cancer risk. The association investigations were identified from PubMed, Cochrane Library, and China Biological Medicine Database on March 1, 2014...
December 2016: Technology in Cancer Research & Treatment
https://www.readbyqxmd.com/read/26596915/automated-monte-carlo-simulation-of-proton-therapy-treatment-plans
#15
Joost Mathijs Verburg, Clemens Grassberger, Stephen Dowdell, Jan Schuemann, Joao Seco, Harald Paganetti
Simulations of clinical proton radiotherapy treatment plans using general purpose Monte Carlo codes have been proven to be a valuable tool for basic research and clinical studies. They have been used to benchmark dose calculation methods, to study radiobiological effects, and to develop new technologies such as in vivo range verification methods. Advancements in the availability of computational power have made it feasible to perform such simulations on large sets of patient data, resulting in a need for automated and consistent simulations...
December 2016: Technology in Cancer Research & Treatment
https://www.readbyqxmd.com/read/26596914/normal-brain-sparing-with-increasing-number-of-beams-and-isocenters-in-volumetric-modulated-arc-beam-radiosurgery-of-multiple-brain-metastases
#16
Sabbir Hossain, Vance Keeling, Kimberly Hildebrand, Salahuddin Ahmad, David A Larson, Arjun Sahgal, Lijun Ma
Recent studies have reported about the application of volumetric-modulated arc radiotherapy in the treatment of multiple brain metastases. One of the key concerns for these radiosurgical treatments lies in the integral dose within the normal brain tissue, as it has been shown to increase with increasing number of brain tumors treated. In this study, we investigate the potential to improve normal brain tissue sparing specific to volumetric-modulated arc radiotherapy by increasing the number of isocenters and arc beams...
December 2016: Technology in Cancer Research & Treatment
https://www.readbyqxmd.com/read/26589726/emerging-role-of-mri-for-radiation-treatment-planning-in-lung-cancer
#17
David C P Cobben, Hans C J de Boer, Rob H Tijssen, Emma G G M Rutten, Marco van Vulpen, Jurgen Peerlings, Esther G C Troost, Aswin L Hoffmann, Astrid L H M W van Lier
Magnetic resonance imaging (MRI) provides excellent soft-tissue contrast and allows for specific scanning sequences to optimize differentiation between various tissue types and properties. Moreover, it offers the potential for real-time motion imaging. This makes magnetic resonance imaging an ideal candidate imaging modality for radiation treatment planning in lung cancer. Although the number of clinical research protocols for the application of magnetic resonance imaging for lung cancer treatment is increasing (www...
December 2016: Technology in Cancer Research & Treatment
https://www.readbyqxmd.com/read/26546576/simulation-based-cryosurgery-training-variable-insertion-depth-planning-in-prostate-cryosurgery
#18
Anjali Sehrawat, Robert Keelan, Kenji Shimada, Dona M Wilfong, James T McCormick, Yoed Rabin
A proof-of-concept for an advanced-level computerized training tool for cryosurgery is demonstrated, based on three-dimensional cryosurgery simulations and a variable insertion depth strategy for cryoprobes. The objective for system development is two-fold: to identify a cryoprobe layout in order to best match a planning isotherm with the target region shape and to verify that cryoprobe placement does not violate accepted geometric constraints. System validation has been performed by collecting training data from 17 surgical residents having no prior experience or advanced knowledge of cryosurgery...
December 2016: Technology in Cancer Research & Treatment
https://www.readbyqxmd.com/read/26525748/sensitivity-of-3d-dose-verification-to-multileaf-collimator-misalignments-in-stereotactic-body-radiation-therapy-of-spinal-tumor
#19
Ni Xin-Ye, Lei Ren, Hui Yan, Fang-Fang Yin
PURPOSE: This study aimed to detect the sensitivity of Delt 4 on ordinary field multileaf collimator misalignments, system misalignments, random misalignments, and misalignments caused by gravity of the multileaf collimator in stereotactic body radiation therapy. METHODS: (1) Two field sizes, including 2.00 cm (X) × 6.00 cm (Y) and 7.00 cm (X) × 6.00 cm (Y), were set. The leaves of X1 and X2 in the multileaf collimator were simultaneously opened. (2) Three cases of stereotactic body radiation therapy of spinal tumor were used...
December 2016: Technology in Cancer Research & Treatment
https://www.readbyqxmd.com/read/26466603/the-diagnostic-efficacy-and-biological-effects-of-microrna-29b-for-colon-cancer
#20
Leping Li, Ying Guo, Yuezhi Chen, Jinshen Wang, Lei Zhen, Xiaobo Guo, Jinglei Liu, Changqing Jing
BACKGROUND: Colorectal cancer is one of the most common cancers worldwide in terms of both incidence and mortality. The associations of expressions of tissue and plasma miR-29b were not detected in this study. METHODS: There are 400 healthy age- and gender-matched controls enrolled in this study in a rate of 1:2. The receiver operating characteristic curve analysis was undertaken using the expression level for miR-29b in the colorectal cancer specimens from patients with cancer and healthy controls to assess the diagnostic accuracy of both tissue and plasma miR-29b levels...
December 2016: Technology in Cancer Research & Treatment
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