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Technology in Cancer Research & Treatment

Hiroshi Hamakawa, Yutaka Takahashi, Ichiro Sakanoue, Tomoki Saito, Naoki Date, Keisuke Tomii, Nobuyuki Katakami, Toshiyuki Imagunbai, Masaki Kokubo
Stereotactic body radiotherapy is an alternative treatment option for small-sized, primary lung cancers and pulmonary metastatic diseases. In the case of local relapse after stereotactic body radiotherapy, salvage pulmonary resection is considered cautiously. However, no study has described the difficulty of the salvage operations. This study aimed to assess the difficulty associated with salvage operative procedures. Eight patients who developed local relapse after stereotactic body radiotherapy and had undergone salvage pulmonary operations were enrolled in this study (stereotactic body radiotherapy group)...
January 1, 2018: Technology in Cancer Research & Treatment
Andreas Ritter, Philipp Bruners, Peter Isfort, Alexandra Barabasch, Joachim Pfeffer, Jula Schmitz, Federico Pedersoli, Martin Baumann
Irreversible electroporation and electrochemotherapy are 2 innovative electroporation-based minimally invasive therapies for the treatment of cancer. Combining nonthermal effects of irreversible electroporation with local application of chemotherapy, electrochemotherapy is an established treatment modality for skin malignancies. Since the application of electrochemotherapy in solid organs is a promising approach, this article describes a novel electrode configuration and field generating method. For the treatment of hepatic malignancies, the shape of the electric field should resemble a spherical 3-dimensional geometry around the target tissue inside the liver...
January 1, 2018: Technology in Cancer Research & Treatment
Angelia Landers, Ryan Neph, Fabien Scalzo, Dan Ruan, Ke Sheng
PURPOSE: The accuracy of dose prediction is essential for knowledge-based planning and automated planning techniques. We compare the dose prediction accuracy of 3 prediction methods including statistical voxel dose learning, spectral regression, and support vector regression based on limited patient training data. METHODS: Statistical voxel dose learning, spectral regression, and support vector regression were used to predict the dose of noncoplanar intensity-modulated radiation therapy (4π) and volumetric-modulated arc therapy head and neck, 4π lung, and volumetric-modulated arc therapy prostate plans...
January 1, 2018: Technology in Cancer Research & Treatment
Jiang-Tao Hou, Li-Na Zhao, Ding-Jun Zhang, Dong-Yong Lv, Wei-Ling He, Bin Chen, Hui-Biao Li, Pei-Ru Li, Li-Zhen Chen, Xin-Lin Chen
DNA mismatch repair was proposed to play a pivotal role in the development and prognosis of colorectal cancer. However, the prognostic value of mismatch repair on colorectal cancer is still unknown. The PubMed, EMBASE, and Cochrane Central Register of Controlled Trials databases were searched. The articles about mismatch repair (including hMLH1, hMSH2, hMSH3, hMSH6, hPMSH1, and hPMSH2) deficiency for the prognosis of patients with colorectal cancer were included in the study. The hazard ratio and its 95% confidence interval were used to measure the impact of mismatch repair deficiency on survival time...
January 1, 2018: Technology in Cancer Research & Treatment
Norio Katoh, Hiroshi Onishi, Yusuke Uchinami, Tetsuya Inoue, Kengo Kuriyama, Kentaro Nishioka, Shinichi Shimizu, Takafumi Komiyama, Naoki Miyamoto, Hiroki Shirato
BACKGROUND: Precise local radiotherapy for adrenal metastasis can prolong the useful life of patients with oligometastasis. The aim of this retrospective, 2-center study was to establish the safety and effectiveness of real-time tumor-tracking radiotherapy and general stereotactic body radiotherapy in treating patients with adrenal metastatic tumors. MATERIALS AND METHODS: Thirteen lesions in 12 patients were treated with real-time tumor-tracking radiotherapy (48 Gy in 8 fractions over 2 weeks) and 8 lesions in 8 patients were treated with general stereotactic body radiotherapy (40-50 Gy in 5-8 fractions over 2 weeks or 60-70 Gy in 10 fractions over 2 weeks)...
January 1, 2018: Technology in Cancer Research & Treatment
Wei-Ping Jie, Jia-Ying Bai, Bin-Bin Li
Oral squamous cell carcinoma is a common malignancy in the head and neck region. Brachytherapy after radical surgery has achieved much progress as a cancer adjuvant treatment. This study focused on the pathologic characteristics of the patients with oral squamous cell carcinoma who underwent seed implantation after radical surgery, and the relationship of these characteristics with prognosis. Thus, 76 patients with oral squamous cell carcinoma, who were treated with surgery and subsequently with iodine 125 (125 I) radioactive seed implantation, were recruited in this study...
January 1, 2018: Technology in Cancer Research & Treatment
Hui Li, Ningxia Ma, Jing Wang, Ying Wang, Chao Yuan, Jing Wu, Meihui Luo, Jiali Yang, Juan Chen, Juan Shi, Xiaoming Liu
Lung cancer remains one of the most common cancer-related deaths worldwide. The cigarette smoking is a risk factor for lung cancer development. Interestingly, the cystic fibrosis transmembrane conductance regulator encoded by CFTR gene, an ATP-binding cassette transporter-class ion channel that conducts chloride and bicarbonate anions across membrane of epithelial cells, has recently been suggested to play a role in the development and progression of many types of cancer. It has been well-documented that mutations of CFTR gene are the cause of cystic fibrosis, the most common fatal hereditary lung disease in Caucasian population; the function of cystic fibrosis transmembrane conductance regulator in the development of lung cancer however has not yet been established...
January 1, 2018: Technology in Cancer Research & Treatment
Ying-Kui Song, Yang Wang, Yi-Yang Wen, Pei Zhao, Zhi-Jie Bian
In recent study, microRNAs have various important functions in diverse biological processes and progression of cancer. In human breast cancer, microRNA-22 has been reported to be downregulated. However, molecular mechanism of microRNA-22 in breast cancer progression and chemosensitivity has not been well studied. In our study, these results demonstrated that microRNA-22 expression levels were significantly reduced in 40 pairs of human breast cancer tissues when compared to normal tissues. Enforced expression of microRNA-22 inhibited activity of cell proliferation and cell migration in breast cancer cells...
January 1, 2018: Technology in Cancer Research & Treatment
Hojin Kim, Jungwon Kwak, Jinhong Jung, Chiyoung Jeong, Kyoungjun Yoon, Sang-Wook Lee, Seung Do Ahn, Eun Kyung Choi, Su Ssan Kim, Byungchul Cho
PURPOSE: To develop an one-click option on treatment planning system that enables for the automated breast FIF planning by combining the Eclipse Scripting application programming interfaces and user-executed programming in Windows. METHODS: Scripting application programming interfaces were designed to promote automation in clinical workflow associated with radiation oncology. However, scripting cannot provide all functions that users want to perform. Thus, a new framework proposes to integrate the benefits of the scripting application and user-executed programming for the automated field-in-field technique...
January 1, 2018: Technology in Cancer Research & Treatment
Huiping He, Xianghui Liao, Qingmei Yang, Yuan Liu, Yan Peng, Hongzhen Zhong, Jun Yang, Huiqing Zhang, Zhonghua Yu, Yufang Zuo, Chengnong Guan, Zumin Xu
BACKGROUND: There is mounting evidence that microRNAs play an important role in nasopharyngeal carcinoma, which is widely prevalent in South China and is the most prevalent metastatic cancer among head and neck cancers. Recently, it has been shown that miR-494 is involved in the progression and prognosis of nasopharyngeal carcinoma. However, little is known about the function and mechanism of miR-494-3p in nasopharyngeal carcinoma. In the present study, we aimed to investigate the effects of miR-494-3p on the migration and invasion of nasopharyngeal carcinoma and to further explore the underlying mechanisms of these processes...
January 1, 2018: Technology in Cancer Research & Treatment
Qing Tu, Zhou Yang, Jianhui Gan, Jian Zhang, Bin Que, Qiaofeng Song, Yan Wang
The immunological function of patients with malignant tumors may be suppressed during the perioperative period. However, details on the effects of transcutaneous electrical acupoint stimulation (TEAS) on immunological function are relatively lacking. We designed this study to examine the effects of TEAS on the immunological function of patients with non-small cell lung cancer (NSCLC) during the perioperative period. Participants (n = 144) were enrolled and randomly assigned into group TEAS or group sham TEAS...
January 1, 2018: Technology in Cancer Research & Treatment
Quoc-Viêt Vincent Pham, Annie-Pier Lavallée, Alexandru Foias, David Roberge, Ellis Mitrou, Philip Wong
PURPOSE: To evaluate the feasibility of a workflow free of a simulation appointment using three-dimensional-printed heads and custom immobilization devices. MATERIALS AND METHODS: Simulation computed tomography scans of 11 patients who received radiotherapy for brain tumors were used to create three-dimensional printable models of the patients' heads and neck rests. The models were three-dimensional-printed using fused deposition modeling and reassembled. Then, thermoplastic immobilization masks were molded onto them...
January 1, 2018: Technology in Cancer Research & Treatment
Yi Yang, Peng Sun, Wei Xu, Wei Xia
BACKGROUND: BIRC7, which encodes Baculoviral inhibitor of apoptosis (IAP) repeat-containing protein 7, is an oncogene in multiple types of cancer. In this study, we examined the association between BIRC7 expression and the clinicopathological characteristics of prostate cancer, the independent prognostic value of BIRC7 in terms of recurrence-free survival, and the molecular mechanisms of its dysregulation. METHODS: Data mining was performed using data from The Cancer Genome Atlas...
January 1, 2018: Technology in Cancer Research & Treatment
Jing Meng, Chengbo Liu, Jeesu Kim, Chulhong Kim, Liang Song
Photoacoustic computed tomography using an ultrasonic array is an attractive noninvasive imaging modality for many biomedical applications. However, the potentially long data acquisition time of array-based photoacoustic computed tomography-usually due to the required time-multiplexing for multiple laser pulses-decreases its applicability for rapid disease diagnoses and the successive monitoring of physiological functions. Compressed sensing is used to improve the imaging speed of photoacoustic computed tomography by decreasing the amount of acquired data; however, the imaging quality can be limited when fewer measurements are used, as traditional compressed sensing considers only the sparsity of the signals in the imaging process...
January 1, 2018: Technology in Cancer Research & Treatment
Kai-Tao Yuan, Bao-Xia Li, Yu-Jie Yuan, Min Tan, Jin-Fu Tan, Wei-Gang Dai, Wei-Dong Feng, Ji-Dong Zuo
Gastric cancer is a deadly disease. Some microRNAs are involved in tumor invasion and metastasis. Underexpression of miR-375 has been correlated with tumorigenesis, treatment resistance, and poor prognosis. In this study, we first analyzed the profiles and prognostic values of miR-375 expression in gastric cancer tissues from a public database, and the expression level of miR-375 in gastric cancer samples and gastric cancer cell lines was then analyzed by quantitative real- time polymerase chain reaction. Significant underexpression of miR-375 was seen in all the gastric cancer samples compared to paired paracarcinoma tissues, and the expression level of miR-375 in the gastric cancer cell lines was negatively associated with the cell migration ability...
January 1, 2018: Technology in Cancer Research & Treatment
Kei Ito, Hiroaki Ogawa, Takuya Shimizuguchi, Keiji Nihei, Tomohisa Furuya, Hiroshi Tanaka, Katsuyuki Karasawa
OBJECT: This study aimed to clarify the outcomes of stereotactic body radiotherapy for spinal metastases with a uniform dose fractionation schedule in our institution. MATERIALS AND METHODS: Patients treated with spine stereotactic body radiotherapy were retrospectively reviewed. The prescribed dose was 24 Gy in 2 fractions. End points were local control, pain control, and adverse events. Local control was defined as elimination, shrinkage, or stable disease in the tumor on imaging evaluations...
January 1, 2018: Technology in Cancer Research & Treatment
Haruo Matsushita, Keiichi Jingu, Rei Umezawa, Takaya Yamamoto, Yojiro Ishikawa, Noriyoshi Takahashi, Yu Katagiri, Noriyuki Kadoya
In recent years, the concept of oligometastases has become accepted and reports on stereotactic body radiotherapy as a treatment method have been published. Lesions in the brain, lung, and liver have been reported as target lesions. However, lymph node oligometastases could be a good candidate for stereotactic body radiotherapy as well. In this study, the usability of stereotactic body radiotherapy for oligometastases to lymph nodes is assessed by researching for each primary site. As a result, we could consider that stereotactic body radiotherapy could be almost well applied for lymph node oligometastases from the breast, gynecological organs, and prostate...
January 1, 2018: Technology in Cancer Research & Treatment
Shilpaa Mukundan, Kriti Sharma, Kim Honselmann, Amy Singleton, Andrew Liss, Biju Parekkadan
Pancreatic cancer is one of the most aggressive cancers with a 5-year patient survival rate of 8.2% and limited availability of therapeutic agents to target metastatic disease. Pancreatic cancer is characterized by a dense stromal cell population with unknown contribution to the progression or suppression of tumor growth. In this study, we describe a microengineered tumor stromal assay of patient-derived pancreatic cancer cells to study the heterotypic interactions of patient pancreatic cancer cells with different types of stromal fibroblasts under basal and drug-treated conditions...
January 1, 2018: Technology in Cancer Research & Treatment
Virginia W Osborn, Anna Lee, Yoshiya Yamada
Stereotactic body radiation therapy and stereotactic radiosurgery have become important treatment options for the treatment of spinal malignancies. A better understanding of dose tolerances with more conformal technology have allowed administration of higher and more ablative doses. In this review, the framework for approaching a patient with spinal metastases and primary tumors will be discussed as well as details on the delivery of this treatment.
January 1, 2018: Technology in Cancer Research & Treatment
Jun Li, David To, Vickie Gunn, Wenyin Shi, Yan Yu, Haisong Liu
PURPOSE: The study was aimed to compare hybrid arc and volumetric-modulated arc therapy treatment plans for fractionated stereotactic radiotherapy of brain tumors. METHODS: Treatment plans of 22 patients were studied. Hybrid arc and volumetric-modulated arc therapy plans were generated using Brainlab iPlanDose and Varian Eclipse treatment planning systems, respectively, with 6 MV photon beams on a Varian TrueBeam STx linear accelerator (Palo Alto, CA). Prescription dose was 54 Gy...
January 1, 2018: Technology in Cancer Research & Treatment
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