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Biomedical Papers of the Medical Faculty of the University Palacký, Olomouc, Czechoslovakia

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https://www.readbyqxmd.com/read/29967563/retinal-abnormatilites-as-a-diagnostic-or-prognostic-marker-of-schizophrenia
#1
Ladislav Hosak, Omar Sery, Evgenii Sadykov, Jan Studnicka
The review is a summary of structural and functional changes in the human retina observed in patients with schizophrenia. The main focus is on the potential of these changes to serve as schizophrenia-specific biomarkers accessible to clinicians. We identified three features of the retina that can be detected non-invasively in humans and which appear to show charateristic changes in schizophrenia: (1) retinal microvasculature displaying abnormally wide venules; (2) electroretinograms indicating altered function of photoreceptors or other cells in the retinal component of the visual pathway; (3) optical coherence tomography pointing to structural differences between the retinae of patients with schizophrenia and those of healthy volunteers...
June 29, 2018: Biomedical Papers of the Medical Faculty of the University Palacký, Olomouc, Czechoslovakia
https://www.readbyqxmd.com/read/29967564/25-gauge-vitrectomy-and-gas-for-the-management-of-rhegmatogenous-retinal-detachment
#2
Miroslav Veith, Zbynek Stranak, Martin Pencak, Jana Vranova, Pavel Studeny
AIMS: To evaluate the anatomical and functional results in patients with rhegmatogenous retinal detachment (RRD) who underwent 25-gauge pars plana vitrectomy (PPV) with gas tamponade. MATERIALS AND METHODS: A retrospective evaluation of 126 eyes of 126 patients (79 men, 47 women) with RRD who underwent 25-gauge PPV with gas tamponade (13% C3F8 in 87 eyes, 20% SF6 in 39 eyes). 113 patients (89.7%), were operated on under local anaesthesia, 13 patients (10.3%) under general anaesthesia...
June 21, 2018: Biomedical Papers of the Medical Faculty of the University Palacký, Olomouc, Czechoslovakia
https://www.readbyqxmd.com/read/29955186/comparison-of-two-modes-of-long-term-ecg-monitoring-to-assess-the-efficacy-of-catheter-ablation-for-paroxysmal-atrial-fibrillation
#3
Jan Chovancik, Veronika Bulkova, Dan Wichterle, Ondrej Toman, Lukas Rybka, Jaroslav Januska, Jindrich Spinar, Martin Fiala
AIMS: Optimal ECG monitoring in detecting recurrences of atrial fibrillation (AF) or atrial tachycardia (AT) after catheter ablation has not been well established. The purpose of this prospective study was to compare the utility of daily ECG monitoring with episodic card recorder (ECR) vs. periodic monitoring with episodic loop recorder (ELR) for the detection of post-blanking AF/AT recurrences during early (Months 4-6) and late (Months 7-12) periods after catheter ablation for paroxysmal AF...
June 21, 2018: Biomedical Papers of the Medical Faculty of the University Palacký, Olomouc, Czechoslovakia
https://www.readbyqxmd.com/read/29955185/the-role-of-ncd64-in-the-diagnosis-of-neonatal-sepsis-in-preterm-newborns
#4
Jan Halek, Martin Novak, Anna Medkova, Tomas Furst, Jarmila Juranova
BACKGROUND: Diagnosing neonatal sepsis is difficult, particularly in preterm newborns. A promising method appears to be evaluation of cell surface markers by flow cytometry. METHODS: This prospective study investigated 217 newborns suspected of having early- or late-onset neonatal sepsis. In all, flow cytometry was used to determine the proportion of CD64-positive neutrophils (nCD64). Based on the clinical course and laboratory test results, newborns were categorized as having proven, possible, clinical or no neonatal sepsis...
June 21, 2018: Biomedical Papers of the Medical Faculty of the University Palacký, Olomouc, Czechoslovakia
https://www.readbyqxmd.com/read/29935492/imipenem-and-normal-saline-with-cyclophosphamide-have-positive-effects-on-the-intestinal-barrier-in-rats-with-sepsis
#5
Junting Yang, Shunwen Zhang, Jiangdong Wu, Jie Zhang, Jiangtao Dong, Peng Guo, Suyu Tang, Wanjiang Zhang, Fang Wu
BACKGROUND: Sepsis is a life-threatening organ dysfunction caused the dysregulation of host inflammatory response and immunosuppression to infection Early recognition and intervention are hence of paramount importance. In this respect the "sepsis bundle" was proposed in 2004 to be instituted in cases of suspected sepsis. OBJECTIVE AND HYPOTHESIS: We hypothesised that a combination treatment of the sepsis bundle with cyclophosphamide would improve the function of the intestinal mucosa and enhance survival in rats with induced sepsis...
June 12, 2018: Biomedical Papers of the Medical Faculty of the University Palacký, Olomouc, Czechoslovakia
https://www.readbyqxmd.com/read/29936527/autoimmune-disease-familial-clustering-and-thyroid-carcinoma-coexistent-with-autoimmune-thyroiditis-in-children-and-adolescence-a-cross-sectional-study-from-the-czech-republic
#6
Renata Pomahacova, Jana Zamboryova, Petra Paterova, Karel Fiklik, Zdenka Cerna, Vaclav Lad, Eva Skalicka, Michal Huml, Josef Sykora
BACKGROUND: The prevalence of autoimmune thyroiditis (AIT), as the most common autoimmune disease (AD) and papillary thyroid cancer (PTC) is steadily rising in children. The aim of this study was to determine the coexistence of other AD and thyroid carcinoma (TC) in AIT. METHODS: The cross-sectional study conducted at a tertiary center comprised AIT children (< 19 years). Data on age/sex, thyroid function and ultrasound, autoantibodies, associated AD, familial occurence of AD and the occurence of TC for each child were collected...
June 7, 2018: Biomedical Papers of the Medical Faculty of the University Palacký, Olomouc, Czechoslovakia
https://www.readbyqxmd.com/read/29936526/comparison-of-the-efficiency-of-femtolasik-and-relex-smile-in-terms-of-dioptric-error-reduction
#7
Zuzana Pavkova, Jana Kacerovska, Martin Kacerovsky
BACKGROUND AND AIMS: Refractive eye surgery is a rapidly expanding field of ophthalmology and corneal surgery is undergoing constant development leading to less invasive technologies. The goal of this study was to compare the most common femtoLASIK surgery with the newer ReLEx SMILE surgery which is gentler to the cornea. The comparison was made in terms of dioptric error reduction. METHODS: The studied cohort of patients consisted of two major groups: 30 patients who underwent femtoLASIK surgery and 30 who underwent ReLEx SMILE surgery...
June 7, 2018: Biomedical Papers of the Medical Faculty of the University Palacký, Olomouc, Czechoslovakia
https://www.readbyqxmd.com/read/29795545/early-manifestation-of-spasticity-after-first-stroke-in-the-territory-of-the-internal-carotid-artery-a-prospective-multicenter-study
#8
Tomas Dornak, Maria Justanova, Romana Konvalinkova, Jan Muzik, Martina Hoskovcova, Martin Srp, Michal Riha, Daniela Navratilova, Pavel Otruba, Ota Gal, Ladislav Dusek, Robert Jech, Martin Bares, Petr Kanovsky
AIMS: The main aim of this study was to provide an estimate of the incidence and prevalence of spasticity following stroke in the internal carotid artery territory for Regional Stroke Centers in the Czech Republic. A secondary goal was to identify predictors for the development of spasticity. METHODS: In a prospective cohort study, 256 consecutive patients with clinical signs of central paresis due to a first-ever stroke were examined in the acute stage. All patients had primary stroke of carotid origin and paresis of the upper and/or lower limb for longer than 7 days after stroke onset...
May 23, 2018: Biomedical Papers of the Medical Faculty of the University Palacký, Olomouc, Czechoslovakia
https://www.readbyqxmd.com/read/29795544/the-effects-of-sustained-manual-pressure-stimulation-according-to-vojta-therapy-on-heart-rate-variability
#9
Jaroslav Opavsky, Martina Slachtova, Miroslav Kutin, Pavel Hok, Petr Uhlir, Hana Opavska, Petr Hlustik
BACKGROUND: The physiotherapeutic technique of Vojta reflex locomotion is often accompanied by various autonomic activity changes and unpleasant sensations. It is unknown whether these effects are specific to Vojta Therapy. Therefore, the aim of this study was to compare changes in cardiac autonomic control after Vojta reflex locomotion stimulation and after an appropriate sham stimulation. METHODS: A total of 28 young healthy adults (20.4 - 25.7 years) were enrolled in this single-blind randomized cross-over study...
May 23, 2018: Biomedical Papers of the Medical Faculty of the University Palacký, Olomouc, Czechoslovakia
https://www.readbyqxmd.com/read/29795543/extraction-of-a-dislocated-leadless-pacemaker-in-a-patient-with-infective-endocarditis-and-repeated-endocardial-and-epicardial-pacing-system-infections
#10
Milos Taborsky, Tomas Skala, Martin Kocher, Marian Fedorco
BACKGROUND: Leadless pacemakers (PMs) were recently introduced to address the complication rate of standard PMs with transvenous leads. METHODS AND RESULTS: A 34-year old male with a history of intravenous substance abuse and a chronic type C hepatitis developed a complete atrioventricular block after cardiac surgery for infective endocarditis. Repeatedly, endo- and epi-cardially implanted PMs had to be explanted due to infection. A leadless MICRA pacemaker was successfully implanted with a dislocation into pulmonary artery several days after implantation...
May 23, 2018: Biomedical Papers of the Medical Faculty of the University Palacký, Olomouc, Czechoslovakia
https://www.readbyqxmd.com/read/29790489/inhibitory-effect-of-hop-fractions-against-gram-positive-multi-resistant-bacteria-a-pilot-study
#11
Katerina Bogdanova, Milan Kolar, Katerina Langova, Martin Dusek, Alexandr Mikyska, Vanda Bostikova, Pavel Bostik, Jana Olsovska
AIM: Our research focused on the antimicrobial effects of purified hop (Humulus lupulus L.) fractions including α-bitter acids (humulones), β-bitter acids (lupulones) and xanthohumol, and a commercial CO2 hop extract of bitter acids against reference and multi-resistant strains of Gram-positive and Gram-negative bacteria and against selected yeast strains. METHODS: In vitro testing of antimicrobial activity was performed according to standard testing protocols (EUCAST)...
May 23, 2018: Biomedical Papers of the Medical Faculty of the University Palacký, Olomouc, Czechoslovakia
https://www.readbyqxmd.com/read/29790488/monitoring-after-radiofrequency-ablation-of-liver-tumors-contrast-enhanced-ultrasound-ceus-vs-contrast-enhanced-computer-tomography-cect-two-days-after-procedure
#12
Eva Korcakova, Hynek Mirka, Vaclav Liska, Petr Hosek, Kristyna Bajcurova
AIM: Our research evaluated the ability of contrast-enhanced ultrasound (CEUS) and contrast enhanced computer tomography (CECT), performed 48 h after radiofrequency ablation (RFA), to detect residual tumor tissue. As recently published studies have evaluated periprocedural CEUS performed within 24 h after procedure and their results were not satisfactory, it seems that postponing the control test by one day could increase the sensitivity of both methods. PATIENTS AND METHODS: We evaluated 33 patients with 37 lesions, who met the criteria for our study...
May 23, 2018: Biomedical Papers of the Medical Faculty of the University Palacký, Olomouc, Czechoslovakia
https://www.readbyqxmd.com/read/29765174/treatment-of-retinal-capillary-hemangioma-using-810-nm-infrared-laser
#13
Pavel Pochop, Martina Kodetova, Dagmar Dotrelova
AIM: Presentation of the efficacy of infrared laser for the treatment of retinal capillary hemangioma (RCH). METHODS: The treatment and follow-up of nine eyes (fourteen tumors of different sizes and localizations) in seven patients (five children) with RCH. Infrared diode laser (810 nm) was used for modified transpupillary thermotherapy (TTT) in long exposition mode and power between 200 and 1200 mW with a beam diameter of 2 mm (indirect ophthalmoscope, +28 D or +40 D lens) or 0...
May 16, 2018: Biomedical Papers of the Medical Faculty of the University Palacký, Olomouc, Czechoslovakia
https://www.readbyqxmd.com/read/29765170/bk-virus-induced-renal-allograft-nephropathy
#14
Karel Krejci, Tomas Tichy, Jana Bednarikova, Kamil Zamboch, Josef Zadrazil
BK virus nephropathy (BKVN) is a serious opportunistic infection threatening renal function especially during the first year after transplantation. Its incidence is now on the rise and is closely related to the level of the recipient's immune system inhibition. This is more intensive with current trends in transplantation medicine, where more potent immunosuppressive protocols are used and more aggressive antirejection therapy is applied. In the absence of BK virus (BKV) specific therapy and limited treatment options for advanced BKVN, active screening of BKV replication and subsequent preemptive adjustment of immunosuppression are essential measures to prevent BKVN...
May 16, 2018: Biomedical Papers of the Medical Faculty of the University Palacký, Olomouc, Czechoslovakia
https://www.readbyqxmd.com/read/29765165/detection-of-cytomegalovirus-dna-in-fecal-samples-as-a-method-for-cmv-enterocolitis-diagnosis-after-allogeneic-stem-cell-transplantation
#15
Alzbeta Zavrelova, Jakub Radocha, Lenka Pliskova, Pavla Paterova, Eva Vejrazkova, Jiri Cyrany, Filip Gabalec, Miroslav Podhola, Pavel Zak
BACKGROUND: Cytomegalovirus enterocolitis is a rare but potentially life threatening complication after allogeneic stem cell transplantation. Its early diagnosis and treatment are essential for a successful outcome. OBJECTIVE: To determine the potential benefit of fecal CMV DNA detection in the diagnosis of CMV colitis among stem cell transplant recipients. STUDY DESIGN: Biopsies from the lower gastrointestinal tract, taken during 69 episodes of diarrhea, were compared with fecal samples previously examined for CMV DNA in 45 patients after allogeneic stem cell transplantation...
May 16, 2018: Biomedical Papers of the Medical Faculty of the University Palacký, Olomouc, Czechoslovakia
https://www.readbyqxmd.com/read/29765173/hemodiafiltration-and-plasma-levels-of-axitinib-in-a-patient-with-metastatic-renal-clear-cell-carcinoma
#16
Jindrich Kopecky, Alena Ticha, Hana Janeckova, Melichar Bohuslav
BACKGROUND: The standard treatment for metastatic renal cancer is based on vascular endothelial growth factor (VEGF) and mammalian target of rapamycin (mTor) inhibitors. Compared to other advanced tumors, the treatment of renal cancer is highly affected by impaired renal function; therefore, patients with severe renal insufficiency, including patients on hemodialysis, are generally excluded from clinical trials. CASE REPORT: In the present manuscript we present the case of a renal cancer patient who underwent bilateral nephrectomy and received two lines of treatment...
May 15, 2018: Biomedical Papers of the Medical Faculty of the University Palacký, Olomouc, Czechoslovakia
https://www.readbyqxmd.com/read/29765172/dietary-sucrose-regulates-the-expression-of-the-cd36-gene-in-hepatic-tissue-of-rats-with-obesity-and-non-alcoholic-fatty-liver-disease-nafld
#17
Rodolfo Quintana Castro, Ida Soto Rodriguez, Rosa A Deschamps Lago, Peter Grube Pagola, Jorge Rodriguez Antolin, Adriana Peres Quintal, Jaime Rivera Rivera, Alfonso Alexander Aguilera
AIM: To evaluate the mRNA expression levels of Cd36 in adipose and hepatic tissues, in rats with NAFLD after the consumption of sucrose for 10 and 20 weeks. METHODS: Twenty Wistar rats, all nearly 21 days old were divided into two experimental groups (NAFLD-10 and NAFLD-20), that received a standard diet (2014 Teklad Global) plus 30% sucrose in their drinking water for 10 and 20 weeks and the control groups (C Groups). Variables such as body weight, food intakes, and serum parameters were measured...
June 2018: Biomedical Papers of the Medical Faculty of the University Palacký, Olomouc, Czechoslovakia
https://www.readbyqxmd.com/read/29765171/risks-and-protective-factors-for-triple-negative-breast-cancer-with-a-focus-on-micronutrients-and-infections
#18
Dagmar Horakova, Katerina Bouchalova, Karel Cwiertka, Ladislav Stepanek, Jana Vlckova, Helena Kollarova
Triple negative breast cancer (TNBC) is an aggressive form of breast cancer (BC) with a poor prognosis. Second, patients cannot benefit from targeted therapy, except for those with BRCA1/2 mutations, for whom poly (ADP-ribose) polymerase (PARP) inhibition therapy using olaparib has recently been approved. As global priorities continue to be epidemiological analysis of BC risk factors and early diagnosis, this review focuses on the risks and protective factors associated with TNBC. A PubMed keyword search for new knowledge on the risks and protective factors for TNBC was carried out...
June 2018: Biomedical Papers of the Medical Faculty of the University Palacký, Olomouc, Czechoslovakia
https://www.readbyqxmd.com/read/29765169/m1-m2-macrophage-polarization-in-human-obese-adipose-tissue
#19
Jaroslava Chylikova, Jana Dvorackova, Zdenek Tauber, Vojtech Kamarad
Obesity and insulin resistance are closely associated with chronic inflammation in adipose tissue, where macrophages play an important role. Adipose tissue macrophages can be divided into two main phenotypes: the classical M1 macrophages and alternatively activated macrophages M2. M1 macrophages produce pro-inflammatory cytokines (TNF-α, interleukin IL-6 and MCP-1) and thus contribute to the development of insulin resistance. On the other hand, M2 macrophages, anti-inflammatory, are involved in the maintenance of tissue homeostasis and are typical in the adipose tissue of slender individuals...
June 2018: Biomedical Papers of the Medical Faculty of the University Palacký, Olomouc, Czechoslovakia
https://www.readbyqxmd.com/read/29765168/mucosal-delivery-systems-of-antihypertensive-drugs-a-practical-approach-in-general-practice
#20
Lukasz P Bialy, Cezary Wojcik, Izabela Mlynarczuk-Bialy
Patients who are unable to receive oral medication (p.o.) are a major problem in outpatient settings, especially in home health care systems. Mucosal administration of drugs offers an alternative to the oral route, especially when the parenteral mode cannot be used. There are three main pathways of mucosal administration: sublingual/buccal, intranasal and rectal. We discuss the possibility of mucosal delivery of antihypertensive drugs. Perindopril arginine and Amlodipine besylate are registered in the EU as orodispersible tablets for oromucosal delivery, however, they are not available in all countries...
June 2018: Biomedical Papers of the Medical Faculty of the University Palacký, Olomouc, Czechoslovakia
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