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Biomedical Papers of the Medical Faculty of the University Palacký, Olomouc, Czechoslovakia

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https://www.readbyqxmd.com/read/27886280/starvation-and-antibiotics-induced-formation-of-persister-cells-in-pseudomonas-aeruginosa
#1
Patrik Mlynarcik, Milan Kolar
BACKGROUND: Planktonic stationary and exponential cultures of Pseudomonas aeruginosa are highly resistant to killing by bactericidal antimicrobials because of the presence of persisters, cells that are multidrug tolerant and play a key role in the recalcitrance of biofilm infections. AIM: The aim of this study was to investigate the formation of persister cells in P. aeruginosa stationary vs. exponential cultures using different class antimicrobials. METHODS: The susceptibilities of P...
November 23, 2016: Biomedical Papers of the Medical Faculty of the University Palacký, Olomouc, Czechoslovakia
https://www.readbyqxmd.com/read/27876898/treatment-of-brain-metastases
#2
Marcel Matzenauer, David Vrana, Melichar Bohuslav
BACKGROUND: Brain metastases are a very common neurological sequela in cancer patients. The ability of current anti-cancer therapies to prolong overall survival is beleaguered by this development in the case of a number of different cancers. This review provides a general overview of relevant treatment modalities, highlights major decision strategies used in selecting the optimal treatment algorithm and summarizes important steps necessary before initiating therapy. METHODS: A PubMED database search was done to identify publications describing the treatment of brain metastases including surgery, radiotherapy and symptomatic care...
November 23, 2016: Biomedical Papers of the Medical Faculty of the University Palacký, Olomouc, Czechoslovakia
https://www.readbyqxmd.com/read/27876897/mmps-and-timps-expression-in-facial-tissue-of-children-with-cleft-lip-and-palate
#3
Liene Smane-Filipova, Mara Pilmane, Ilze Akota
BACKGROUND AND AIMS: Morphogenesis of the upper lip and palate is a complex process involving highly regulated interactions between epithelial and mesenchymal cells. Genetic evidence in humans and mice indicates the involvement of matrix metalloproteinases (MMPs) and their endogenous tissue inhibitors (TIMPs) in cleft lip palate (CLP) aetiology. This study investigated whether expression of MMP-2, MMP-8, MMP-9, TIMP-2, and TIMP-4, which are essential for the upper lip and palate fusion, is dysregulated in children with CLP...
November 21, 2016: Biomedical Papers of the Medical Faculty of the University Palacký, Olomouc, Czechoslovakia
https://www.readbyqxmd.com/read/27833172/cranberry-intervention-in-patients-with-prostate-cancer-prior-to-radical-prostatectomy-clinical-pathological-and-laboratory-findings
#4
Vladimir Student, Ales Vidlar, Jan Bouchal, Jana Vrbkova, Zdenek Kolar, Milan Kral, Pavel Kosina, Jitka Vostalova
BACKGROUND AND OBJECTIVES: Recently, we described an inverse association between cranberry supplementation and serum prostate specific antigen (PSA) in patients with negative biopsy for prostate cancer (PCa) and chronic nonbacterial prostatitis. This double blind placebo controlled study evaluates the effects of cranberry consumption on PSA values and other markers in men with PCa before radical prostatectomy. METHODS: Prior to surgery, 64 patients with prostate cancer were randomized to a cranberry or placebo group...
November 10, 2016: Biomedical Papers of the Medical Faculty of the University Palacký, Olomouc, Czechoslovakia
https://www.readbyqxmd.com/read/27833171/serum-levels-of-soluble-adhesion-molecules-in-newly-diagnosed-acute-myeloid-leukemia-and-in-complete-remission-suggest-endothelial-cell-activation-by-myeloblasts
#5
Tomas Kupsa, Jan Vanek, Zak Pavel, Ladislav Jebavy, Jan M Horacek
BACKGROUND AND AIMS: Despite high-dose multi-agent chemotherapy and allogeneic stem cell transplantation, the relapse rate of acute myeloid leukemia (AML) is high. Further, the disease is highly resistent to drugs. We speculated that deeper understanding of AML-endothelial cell interactions might provide new targets for selective modulation of the AML microenvironment and form the basis for novel treatment approaches. In this study, we evaluated levels of endothelium derived soluble adhesion molecules in active disease and in complete remission (CR) and their relationship with inflammatory cytokines...
November 10, 2016: Biomedical Papers of the Medical Faculty of the University Palacký, Olomouc, Czechoslovakia
https://www.readbyqxmd.com/read/27833170/ischemic-stroke-in-paediatrics-narrative-review-of-the-literature-and-two-cases
#6
Jozef Klucka, Petr Stourac, Roman Stoudek, Michaela Toukalkova, Hana Harazim, Martina Kosinova, Alena Stouracova, Andrej Mrlian, Petr Suk, Jan Malaska
BACKGROUND: Stroke is a rare condition in childhood with an estimated incidence of between 1.3-13/100.000 patients. Clinical manifestation and risk factors for paediatric stroke are different from those of adults. The uncommon incidence, age-associated difference and plethora of clinical symptoms make the diagnosis of such strokes extremely difficult and often delayed. The history and clinical examination should point to diseases or predisposing factors. Neuroimaging (DWI MR) is the golden standard for diagnosis of paediatric stroke and other investigations can be considered according to the clinical condition...
November 10, 2016: Biomedical Papers of the Medical Faculty of the University Palacký, Olomouc, Czechoslovakia
https://www.readbyqxmd.com/read/27829688/prevalence-of-incomplete-interlobar-fissures-of-the-lung
#7
Zuzana Sedlackova, Filip Ctvrtlik, Miroslav Herman
BACKGROUND: Some patients benefit from accurate integrity assessment of pulmonary fissures. There are a number of methods for the assessment of incomplete interlobar fissures: imaging techniques, endobronchial methods measuring collateral air flow, a perioperative view, and autopsies used in research into pulmonary anatomy. METHODS AND RESULTS: We performed a computerized advanced search for primary evidence in the PubMed (Public/Publisher MEDLINE) and Google Scholar electronic databases using the following terms: incomplete and fissure...
October 26, 2016: Biomedical Papers of the Medical Faculty of the University Palacký, Olomouc, Czechoslovakia
https://www.readbyqxmd.com/read/27812084/nutrition-oxidative-stress-and-intestinal-dysbiosis-influence-of-diet-on-gut-microbiota-in-inflammatory-bowel-diseases
#8
Giovanni Tomasello, Margherita Mazzola, Angelo Leone, Emanuele Sinagra, Giovanni Zummo, Felicia Farina, Provvidenza Damiani, Francesco Cappello, Alice Gerges Geagea, Abdo Jurjus, Tarek Bou Assi, Massimiliano Messina, Francesco Carini
BACKGROUND: Microbiota refers to the population of microorganisms (bacteria, viruses and fungi) that inhabit the entire gastrointestinal tract, more particularly the colon whose role is to maintain the integrity of the intestinal mucosa and control the proliferation of pathogenic bacteria. Alteration in the composition of the gut microbiota is called dysbiosis. Dysbiosis redisposes to inflammatory bowel diseases such as ulcerative colitis, Crohn disease and indeterminate colitis. METHODS: The purpose of this literature review is to elucidate the influence of diet on the composition of the gastrointestinal microbiota in the healthy gut and the role of diet in the development of dysbiosis...
October 26, 2016: Biomedical Papers of the Medical Faculty of the University Palacký, Olomouc, Czechoslovakia
https://www.readbyqxmd.com/read/27752149/congenital-bronchopulmonary-malformation-ct-histopathological-correlation
#9
Martin Kyncl, Martin Koci, Lea Ptackova, Ludmila Hornofova, Fabian Ondrej, Jiri Snajdauf, Marcela Pychova
BACKGROUND: This study evaluated the accuracy of postnatal computed tomography (CT) imaging in the identification of congenital bronchopulmonary malformation (BPM) in comparison with histopathological analysis. METHODS: CT scans of prenatally diagnosed BPMs from 24 patients with available histology were analysed retrospectively. The CT images were reviewed blinded to histological findings by two radiologists. Specific diagnosis was assigned based on predetermined criteria...
October 17, 2016: Biomedical Papers of the Medical Faculty of the University Palacký, Olomouc, Czechoslovakia
https://www.readbyqxmd.com/read/27752148/mcrapd-unlike-maldi-tof-ms-is-a-suitable-candidate-for-routine-discrimination-of-new-haemophilus-influenzae-strain-acquisition-in-chronic-obstructive-pulmonary-disease-copd-and-cystic-fibrosis
#10
Vladislav Raclavsky, Nikola Stromerova, Dana Safarova, Jan Bardon, Jaromir Zatloukal, Martin Zapalka, Petr Jakubec, Lucie Navratilova, Radko Novotny
BACKGROUND AND AIMS: Haemophilus influenzae new strain acquisition has been demonstrated to increase the relative risk of acute exacerbation fourfold in contrast to colonisation or chronic infection by the same strain in chronic obstructive pulmonary disease (COPD). Unfortunately, molecular typing techniques are not suitable for routine use due to cost, labour-intensity and need for special expertise. We tested two techniques potentially useful for routine typing, namely the newly available MALDI-TOF MS and the modified McRAPD compared to MLST as the gold standard...
October 6, 2016: Biomedical Papers of the Medical Faculty of the University Palacký, Olomouc, Czechoslovakia
https://www.readbyqxmd.com/read/27752150/high-grade-urothelial-bladder-cancer-in-children-a-case-report-and-critical-analysis-of-the-literature
#11
Milan Kral, Jaroslav Michalek, Jozef Skarda, Tomas Tichy, Oldrich Smakal, Roman Kodet, Vladimir Student
BACKGROUND: Bladder cancer is relatively common in adults. In children, it is extremely rare and in the majority of cases, low grade, low stage urothelial cancers are found. CASE REPORT: We describe the diagnostic, therapeutic, and follow-up management of bladder cancer in a 3-year-old boy examined for painless hematuria. Transurethral resection of the tumor was performed and T1 high grade urothelial cancer with osseous metaplasia was found in definitive specimens...
October 3, 2016: Biomedical Papers of the Medical Faculty of the University Palacký, Olomouc, Czechoslovakia
https://www.readbyqxmd.com/read/27725783/minimally-invasive-thoracoscopic-approach-to-thoracolumbar-junction-fractures
#12
Jan Kocis, Martin Kelbl, Peter Wendsche, Radek Vesely
AIMS: A retrospective analysis of patients with thoracolumbar junction fractures who underwent video-assisted thoracoscopic surgery via a minimally invasive approach (minithoracotomy) for reconstruction of the anterior spinal column. METHODS: Between 2002 and 2014, a total of 176 patients were treated by this technique. The patients received either posterior stabilization and, at the second stage, the minimally invasive technique via an anterior approach, or the minimally invasive anterior procedure alone...
October 3, 2016: Biomedical Papers of the Medical Faculty of the University Palacký, Olomouc, Czechoslovakia
https://www.readbyqxmd.com/read/27646496/prospective-randomized-placebo-controlled-double-blind-clinical-study-comparing-the-safety-and-efficacy-of-heparin-and-nadroparin-administered-in-therapeutic-doses-to-placebo-in-acute-ischemic-stroke-pilot-study
#13
Jana Dluha, Stefan Sivak, Egon Kurca, Robert Dusenka, Klaudia Kalmarova, Monika Turcanova Koprusakova, Ema Kantorova, Vladimir Nosal
AIMS: This study aims to compare the safety and efficacy of heparin and nadroparin in order to provide an additional therapeutic option for patients with acute ischemic stroke in, whom systemic thrombolysis was excluded, or thrombectomy could not be performed. METHODS: We describe a prospective randomized double-blind placebo-controlled pilot study in acute ischemic stroke. The therapeutic window was between 4.5 and 24 h after the onset of stroke. During the first 24 h of treatment, the patients divided into 3 groups received placebo, heparin or nadroparin (in therapeutic doses)...
September 19, 2016: Biomedical Papers of the Medical Faculty of the University Palacký, Olomouc, Czechoslovakia
https://www.readbyqxmd.com/read/27646495/prospective-study-of-hypothalamo-hypophyseal-dysfunction-in-children-and-adolescents-following-traumatic-brain-injury
#14
David Krahulik, Darina Aleksijevic, Vratislav Smolka, Eva Klaskova, Petra Venhacova, Miroslav Vaverka, Vladimir Mihal, Jirina Zapletalova
BACKGROUND AND AIMS: Retrospective studies of TBI have found a neuroendocrine dysfunction following traumatic brain injury in 23 to 60% of adults and 15 to 21% of children. Our aims were to determine the prevalence of hypothalamo-hypophyseal dysfunction in children following brain injury, assess its relationship to the type of injury and the course of the acute post-traumatic phase. PATIENTS AND METHODS: Body development (growth, pubertal development, and skeletal maturity) were evaluated in 58 patients (21 girls) after a brain injury rated 3 to 12 on the Glasgow Coma Scale (GCS)...
September 19, 2016: Biomedical Papers of the Medical Faculty of the University Palacký, Olomouc, Czechoslovakia
https://www.readbyqxmd.com/read/27641140/magnetic-resonance-cholangiopancreatography-mrcp-using-new-negative-per-oral-contrast-agent-based-on-superparamagnetic-iron-oxide-nanoparticles-for-extrahepatic-biliary-duct-visualization-in-liver-cirrhosis
#15
Katerina Polakova, Ingrid Mocikova, Dana Purova, Pavel Tucek, Pavel Novak, Katerina Novotna, Izak Niko, Radoslav Bielik, Radek Zboril, Miroslav Herman
BACKGROUND AND AIMS: Magnetic resonance cholangiopancreatography (MRCP) is often used for imaging of the biliary tree and is required by surgeons before liver transplantation. Advanced liver cirrhosis and ascites in patients however present diagnostic problems for MRCP. The aim of this study was to find out if the use of our negative per-oral contrast agent containing superparamagnetic iron oxide nanoparticles (SPIO) in MRCP is helpful for imaging of hepatobiliary tree in patients with liver cirrhosis...
September 15, 2016: Biomedical Papers of the Medical Faculty of the University Palacký, Olomouc, Czechoslovakia
https://www.readbyqxmd.com/read/27605399/procalcitonin-is-more-likely-to-be-released-by-the-fetus-rather-than-placental-tissue-during-chorioamnionitis
#16
Zbynek Stranak, Jaroslav Feyereisl, Peter Korcek, Simona Feyereislova, Ladislav Krofta
AIMS: To analyze the relationship between maternal, cord blood and neonatal procalcitonin (PCT) levels in preterm deliveries with and without histologically proven chorioamnionitis (HCA). METHODS: 91 mother-infant pairs from 24+0 to 33+0 gestational weeks were analyzed. Procalcitonin was measured in all mothers within 24 hours before and subsequently in cord blood and in neonates within the first two hours after delivery. PCT levels were analysed in relationship to HCA and clinical outcome...
September 5, 2016: Biomedical Papers of the Medical Faculty of the University Palacký, Olomouc, Czechoslovakia
https://www.readbyqxmd.com/read/27605398/glycoprotein-asporin-as-a-novel-player-in-tumour-microenvironment-and-cancer-progression
#17
Dana Simkova, Gvantsa Kharaishvili, Eva Slabakova, Paul G Murray, Jan Bouchal
BACKGROUND: Small leucine rich proteoglycans (SLRPs), major non-collagen components of the extracellular matrix (ECM), have multiple biological roles with diverse effects. Asporin, a member of the SLRPs class I, competes with other molecules in binding to collagen and affects its mineralization. Its role in cancer is only now being elucidated. METHODS: The PubMed online database was used to search relevant reviews and original articles. Furthermore, altered asporin expression was analysed in publicly available genome-wide expression data at the Gene Expression Omnibus database...
September 5, 2016: Biomedical Papers of the Medical Faculty of the University Palacký, Olomouc, Czechoslovakia
https://www.readbyqxmd.com/read/27641357/short-sheath-benefit-in-radial-artery-injury-after-pci-optical-coherence-tomography-serial-study
#18
Tereza Novakova, Jan Kanovsky, Roman Miklik, Otakar Bocek, Martin Poloczek, Petr Jerabek, Lenka Privarova, Tomas Ondrus, Jiri Jarkovsky, Klara Benesova, Jindrich Spinar, Petr Kala
BACKGROUND AND AIMS: Transradial catheterization is the predominant access site for coronary catheterization and percutaneous coronary interventions (PCI). Previous studies have reported a high incidence of radial artery (RA) injury. The aim of this investigation was to evaluate the incidence of RA injury using last generation optical coherence tomography (OCT) intravascular imaging in a serial manner. METHODS: 100 patients with a diagnosis of non-ST-elevation myocardial infarction (nSTEMI) treated by PCI were enrolled...
September 2016: Biomedical Papers of the Medical Faculty of the University Palacký, Olomouc, Czechoslovakia
https://www.readbyqxmd.com/read/27641139/radiotherapy-management-of-brain-metastases-using-conventional-linear-accelerator
#19
Marcel Matzenauer, David Vrana, Zuzana Vlachova, Karel Cwiertka, Ondrej Kalita, Bohuslav Melichar
BACKGROUND AND AIMS: As treatments for primary cancers continue to improve life expectancy, unfortunately, brain metastases also appear to be constantly increasing and life expectancy for patients with brain metastases is low. Longer survival and improved quality of life may be achieved using localised radiological and surgical approaches in addition to low dose corticosteroids. Stereotactic brain radiotherapy is one rapidly evolving localized radiation treatment. This article describes our experience with stereotactic radiotherapy using a linear accelerator...
September 2016: Biomedical Papers of the Medical Faculty of the University Palacký, Olomouc, Czechoslovakia
https://www.readbyqxmd.com/read/27623957/the-long-term-effects-of-probiotics-in-the-therapy-of-ulcerative-colitis-a-clinical-study
#20
Vincenzo Davide Palumbo, Marcello Romeo, Antonella Marino Gammazza, Francesco Carini, Provvidenza Damiani, Giuseppe Damiano, Salvatore Buscemi, Attilio Ignazio Lo Monte, Alice Gerges-Geagea, Abdo Jurjus, Giovanni Tomasello
AIM: Intestinal dysbiosis seems to be the leading cause of inflammatory bowel diseases, and probiotics seems to represent the proper support against their occurrence. Actually, probiotic blends and anti-inflammatory drugs represent a weapon against inflammatory bowel diseases. The present study evaluates the long-term (2 years) effects of combination therapy (mesalazine plus a probiotic blend of Lactobacillus salivarius, Lactobacillus acidophilus and Bifidobacterium bifidus strain BGN4) on ulcerative colitis activity...
September 2016: Biomedical Papers of the Medical Faculty of the University Palacký, Olomouc, Czechoslovakia
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