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Cancer Cell International

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https://www.readbyqxmd.com/read/27895530/alpha-synuclein-contributes-to-malignant-progression-of-human-meningioma-via-the-akt-mtor-pathway
#1
Yiqin Ge, Kan Xu
BACKGROUND: The aim of this study is to explore the expression of alpha-synuclein (α-synuclein) in benign, atypical, and anaplastic meningiomas and determine its role in the malignant progression of meningiomas. METHODS: Expression of α-synuclein was measured in 44 meningioma samples by real-time PCR analysis. The effects of overexpression or knockdown of α-synuclein on meningioma cell growth, invasiveness, and tumorigenicity were determined. RESULTS: Atypical and anaplastic meningiomas displayed significantly greater levels of α-synuclein mRNA, relative to benign tumors...
2016: Cancer Cell International
https://www.readbyqxmd.com/read/27891063/cell-division-cycle-7-kinase-inhibitor-pha-767491-hydrochloride-suppresses-glioblastoma-growth-and-invasiveness
#2
Zubeyde Erbayraktar, Begum Alural, Resat Serhat Erbayraktar, Erdogan Pekcan Erkan
BACKGROUND: Genomic instability is a hallmark of cancer cells, and this cellular phenomenon can emerge as a result of replicative stress. It is possible to take advantage of replicative stress, and enhance it in a targeted way to fight cancer cells. One of such strategies involves targeting the cell division cycle 7-related protein kinase (CDC7), a protein with key roles in regulation of initiation of DNA replication. CDC7 overexpression is present in different cancers, and small molecule inhibitors of the CDC7 have well-documented anti-tumor effects...
2016: Cancer Cell International
https://www.readbyqxmd.com/read/27872579/simultaneous-dual-targeting-of-par-4-and-g6pd-a-promising-new-approach-in-cancer-therapy-quintessence-of-a-literature-review-on-survival-requirements-of-tumor-cells
#3
Ingeborg Elisabeth Cernaj
: The aim of this hypothesis is to propose a new approach in targeted therapy of cancer: The simultaneous, dual targeting of two single molecules, Par-4 and G6PD, rather than inhibition of full-length signaling pathways. RATIONALE: Targeted inhibition of especially two survival signaling pathways (PI3K/AKT/mTOR and MAPK/ERK) is frequently tried, however, a major breakthrough has not yet been reported. Inhibition of complete pathways naturally goes along with a variety of dose-limiting side effects thus contributing to poor efficacy of the administered drugs...
2016: Cancer Cell International
https://www.readbyqxmd.com/read/27843412/overexpression-of-a613t-and-g462t-variants-of-dna-polymerase-%C3%AE-weakens-chemotherapy-sensitivity-in-esophageal-cancer-cell-lines
#4
Yuanyuan Wang, Xiaonan Chen, Qianqian Sun, Wenqiao Zang, Min Li, Ziming Dong, Guoqiang Zhao
BACKGROUND: Human DNA polymerase β (polβ) is a small monomeric protein that is essential for short-patch base excision repair. It plays an important role in regulating the sensitivity of tumor cells to chemotherapy. METHODS: We evaluated the mutation of polβ in a larger cohort of esophageal cancer (EC) patients by RT-PCR and sequencing analysis. The function of the mutation was evaluated by CCK-8, in vivo tumor growth, and flow cytometry assays. RESULTS: There are 229 patients with the polβ mutation, 18 patients with A613T mutation, 12 patients with G462T mutation among 538 ECs...
2016: Cancer Cell International
https://www.readbyqxmd.com/read/27822140/retraction-note-down-regulation-of-mir-133a-and-mir-539-are-associated-with-unfavorable-prognosis-in-patients-suffering-from-osteosarcoma
#5
Alireza Mirghasemi, Afshin Taheriazam, Seyyed Hasan Karbasy, Ali Torkaman, Mohammadreza Shakeri, Emad Yahaghi, Aram Mokarizadeh
[This retracts the article DOI: 10.1186/s12935-015-0237-6.].
2016: Cancer Cell International
https://www.readbyqxmd.com/read/27822139/retraction-note-to-diagnosis-classification-and-grading-of-canine-mammary-tumours-as-a-model-to-study-human-breast-cancer-an-clinico-cytohistopathological-study-with-environmental-factors-influencing-public-health-and-medicine
#6
Radmehr Shafiee, Javad Javanbakh, Nahid Atyabi, Pegah Kheradmand, Danial Kheradmand, Alimohammad Bahrami, Hasti Daraei, Farshid Khadivar
[This retracts the article DOI: 10.1186/1475-2867-13-79.].
2016: Cancer Cell International
https://www.readbyqxmd.com/read/27822138/the-zebrafish-as-a-model-for-studying-neuroblastoma
#7
REVIEW
Diana Corallo, Simona Candiani, Michela Ori, Sanja Aveic, Gian Paolo Tonini
Neuroblastoma is a tumor arising in the peripheral sympathetic nervous system and is the most common cancer in childhood. Since most of the cellular and molecular mechanisms underlying neuroblastoma onset and progression remain unknown, the generation of new in vivo models might be appropriate to better dissect the peripheral sympathetic nervous system development in both physiological and disease states. This review is focused on the use of zebrafish as a suitable and innovative model to study neuroblastoma development...
2016: Cancer Cell International
https://www.readbyqxmd.com/read/27777512/long-non-coding-rna-dbccr1-003-regulate-the-expression-of-dbccr1-via-dnmt1-in-bladder-cancer
#8
Defeng Qi, Jinhui Li, Biao Que, Jialin Su, Mengxi Li, Chaofeng Zhang, Mei Yang, Guoren Zhou, Weidong Ji
BACKGROUND: Many long non coding RNAs have been identified as key modulators in cancer development. A lncRNA, DBCCR1-003, derived from the locus of tumor suppressor gene DBCCR1 (deleted in bladder cancer chromosome region 1), has unknown function. In the present study, we explored function and molecular mechanism of DBCCR1-003 in bladder cancer (BC) development. METHODS: We evaluated the expression levels of DBCCR1-003 in tissues and cells with western blot and quantitative real-time polymerase chain reaction...
2016: Cancer Cell International
https://www.readbyqxmd.com/read/27777511/expression-of-microtubule-associated-protein-tpx2-in-human-gastric-carcinoma-and-its-prognostic-significance
#9
Cuijie Shao, Changsheng Duan, Jiani Wang, Shunlian Luan, Yong Gao, Dan Jin, Deqiang Wang, Yuming Li, Lihua Xu
BACKGROUND: The molecular mechanisms underlying the development and progression of gastric carcinoma remain poorly understood. The main objective of this study was to investigate the expression level of targeting protein for Xenopus kinesin-like protein 2 (TPX2) and its clinical significance in human gastric carcinoma. METHODS: Real-time quantitative polymerase chain reaction (RT-PCR) and western blotting were used to determine the mRNA and protein levels of TPX2 in 20 paired gastric carcinoma tissues and the adjacent normal tissues, and the expression of TPX2 protein in 106 specimens of a gastric carcinoma tissue microarray was determined by immunohistochemistry...
2016: Cancer Cell International
https://www.readbyqxmd.com/read/27752239/the-chimeric-multi-domain-proteins-mediating-specific-dna-transfer-for-hepatocellular-carcinoma-treatment
#10
Encheng Yang, Xiao Li, Ningyi Jin
AIM: This study was aimed to evaluate the therapeutic efficiency of a non-virus based specific chimeric multi-domain DNA transferred with apoptin in human hepatocellular carcinoma (HCC) HepG-2 cells in vitro and in mice H22 cells in vivo. METHODS: We firstly constructed the multi-domain recombinant chimeric proteins based on recombinant proteins [G (yeast GAL4), NG (none GAL4), TG (GAL4 + Tat protein) and TNG (Tat protein)] and pUAS-Apoptin plasmid, and transfected them into human HepG-2 cells...
2016: Cancer Cell International
https://www.readbyqxmd.com/read/27733814/cytologic-studies-of-the-fallopian-tube-in-patients-undergoing-salpingo-oophorectomy
#11
Hao Chen, Robert Klein, Stacy Arnold, Setsuko Chambers, Wenxin Zheng
BACKGROUND: Mounting evidence suggests the fallopian tube as the origin for ovarian high grade serous carcinoma (HGSC). We attempted to identify the tubal cytological features that allow us to distinguish malignant from benign conditions. METHODS: Tubal specimens (n = 56) were collected from patients who underwent bilateral salpingo-oophorectomy (BSO) due to various clinical indications. A standard procedure to collect fallopian tube brushings from freshly received surgical specimens was developed...
2016: Cancer Cell International
https://www.readbyqxmd.com/read/27708551/bone-morphogenetic-protein-2-bmp2-induces-growth-suppression-and-enhances-chemosensitivity-of-human-colon-cancer-cells
#12
Radhakrishnan Vishnubalaji, Shijun Yue, Musaad Alfayez, Moustapha Kassem, Fei-Fei Liu, Abdullah Aldahmash, Nehad M Alajez
BACKGROUND: Molecular profiling of colorectal cancer (CRC) based on global gene expression has revealed multiple dysregulated signalling pathways associated with drug resistance and poor prognosis. However, the role of BMP2 signaling in CRC is not fully characterised. METHODS: Bioinformatics data analysis were conducted on the GSE21510 dataset. Leniviral technology was utilized to stably express BMP2 in the HCT116 CRC model. Gene expression profiling was conducted using Agilent microarray platform while data normalization and bioinformatics were conducted using GeneSpring software...
2016: Cancer Cell International
https://www.readbyqxmd.com/read/27708550/relationship-between-traf6-and-deterioration-of-hcc-an-immunohistochemical-and-in-vitro-study
#13
Jian-Jun Li, Jie Luo, Jing-Ning Lu, Xiao-Na Liang, Yi-Huan Luo, Yong-Ru Liu, Jie Yang, Hua Ding, Gui-Hui Qin, Li-Hua Yang, Yi-Wu Dang, Hong Yang, Gang Chen
OBJECTIVE: To explore the relationship between tumor necrosis factor receptor-associated factor 6 (TRAF6) and the clinicopathological features in HCC as well as its biological function. METHODS: Totally, 412 liver tissues were collected, including 171 hepatocellular carcinoma (HCC) and their corresponding non-tumor tissues, 37 cirrhosis and 33 normal liver tissues. The expression of TRAF6 was assessed by immunohistochemistry. Then, analysis of the correlations between TRAF6 expression and clinicopathological parameters in HCC was conducted...
2016: Cancer Cell International
https://www.readbyqxmd.com/read/27708549/success-of-tumorsphere-isolation-from-who-grade-iv-gliomas-does-not-correlate-with-the-weight-of-fresh-tumor-specimens-an-immunohistochemical-characterization-of-tumorsphere-differentiation
#14
Kyoung Su Sung, Jin-Kyoung Shim, Ji-Hyun Lee, Se Hoon Kim, Sohee Park, Tae-Hoon Roh, Ju Hyung Moon, Eui-Hyun Kim, Sun Ho Kim, Su Jae Lee, Yong Min Huh, Seok-Gu Kang, Jong Hee Chang
BACKGROUND: A trend of stage-by-stage increase in tumorsphere (TS) formation from glioma samples has been reported. Despite this trend, not all surgical specimens give rise to TSs, even World Health Organization (WHO) grade IV gliomas. Furthermore, it has been reported that differences in overall survival of primary glioblastoma patients depends on the propensity of their tumors to form TSs. However, the weights of fresh specimens vary from one surgical isolate to the next. METHODS: Accordingly, we evaluated the relationship between the weights of surgical specimens in WHO grade IV gliomas with the capacity to isolate TSs...
2016: Cancer Cell International
https://www.readbyqxmd.com/read/27708548/kiaa0101-a-target-gene-of-mir-429-enhances-migration-and-chemoresistance-of-epithelial-ovarian-cancer-cells
#15
Hong Chen, Bairong Xia, Tianbo Liu, Mei Lin, Ge Lou
BACKGROUND: Ovarian cancer is a common type of gynecological malignancies, and is the fifth leading cause of cancer-related death in women in the United States. MiR-429 and KIAA0101 have been found to be involved in several human malignancies, respectively. However, the role of miR-429 and KIAA0101, and the correlation between them during development of epithelial ovarian cancer (EOC) remain to be investigated. METHODS: The expression of KIAA0101 in EOC tissues and cells was measured by Quantitative real-time PCR, western blot, and immunochemistry...
2016: Cancer Cell International
https://www.readbyqxmd.com/read/27688736/long-noncoding-rna-anril-is-activated-by-hypoxia-inducible-factor-1%C3%AE-and-promotes-osteosarcoma-cell-invasion-and-suppresses-cell-apoptosis-upon-hypoxia
#16
Xiaokang Wei, Chuanshun Wang, Chunhui Ma, Wei Sun, Haoqing Li, Zhendong Cai
BACKGROUND: Osteosarcoma is the most common malignancy of bone. Intratumoral hypoxia occurs in many solid tumors, where it is associated with the development of aggressive phenotype. ANRIL has been shown to be a long noncoding RNA that facilitates the progression of a number of malignancies. Yet, few studies have explored the expression pattern of ANRIL in osteosarcoma and the effect of hypoxia on ANRIL. METHODS: We evaluated the expression levels of ANRIL in osteosarcoma tissues, adjacent normal tissues and cells with quantitative real-time polymerase chain reaction...
2016: Cancer Cell International
https://www.readbyqxmd.com/read/27688735/altering-bioelectricity-on-inhibition-of-human-breast-cancer-cells
#17
Seher Berzingi, Mackenzie Newman, Han-Gang Yu
BACKGROUND: Membrane depolarization is associated with breast cancer. Depolarization-activated voltage-gated ion channels are directly implicated in the initiation, proliferation, and metastasis of breast cancer. METHODS: In this study, the role of voltage-gated potassium and calcium ion channel modulation was explored in two different invasive ductal human carcinoma cell lines, MDA-MB-231 (triple-negative) and MCF7 (estrogen-receptor-positive). RESULTS: Resting membrane potential is more depolarized in MCF7 and MDA-MB-231 cells compared to normal human mammary epithelial cells...
2016: Cancer Cell International
https://www.readbyqxmd.com/read/27660555/robo3a-and-robo3b-expression-is-regulated-via-alternative-promoters-and-mrna-stability
#18
Anke Ruedel, Mandy Schott, Thomas Schubert, Anja Katrin Bosserhoff
BACKGROUND: The transmembrane receptor family Roundabout (Robo) was described to have an essential role in the developing nervous system. Recent studies demonstrated that Robo3 shows an altered expression in rheumatoid arthritis as well as in melanoma. CONTEXT AND PURPOSE OF THE STUDY: Until today no detailed studies of the two Robo3 isoforms (Robo3A and Robo3B) and their roles in rheumatoid arthritis synovial fibroblasts, respectively malignant melanoma are available...
2016: Cancer Cell International
https://www.readbyqxmd.com/read/27610044/selected-polyphenols-potentiate-the-apoptotic-efficacy-of-glycolytic-inhibitors-in-human-acute-myeloid-leukemia-cell-lines-regulation-by-protein-kinase-activities
#19
Elena de Blas, María Cristina Estañ, María Del Carmen Gómez de Frutos, Javier Ramos, María Del Carmen Boyano-Adánez, Patricio Aller
BACKGROUND: The glycolysis inhibitor 2-deoxy-d-glucose (2-DG) is a safe, potentially useful anti-tumour drug, but its efficacy is normally low when used alone. Recent studies indicated that 2-DG stimulates the PI3K/Akt and MEK/ERK defensive pathways, which limits the apoptotic efficacy in tumour cell lines. We hypothesized that co-treatment with selected polyphenols could improve 2-DG-provoked apoptosis by preventing defensive kinase activation. METHODS: Cell proliferation was measured by cell counting or the MTT assay...
2016: Cancer Cell International
https://www.readbyqxmd.com/read/27601938/cd147-promotes-cell-motility-via-upregulation-of-p190-b-rhogap-in-hepatocellular-carcinoma
#20
Ruo Chen, Shi-Jie Wang, Yang Zhang, Rong Hou, Jian-Li Jiang, Hong-Yong Cui
BACKGROUND: The acquisition of inappropriate migratory feature is crucial for tumor metastasis. Rho-family GTPases including RhoA are molecular switches that play critical roles in regulating cell movement. We investigated the molecular mechanism underlying CD147 induced RhoA deactivation in hepatocellular carcinoma (HCC) cells. METHODS: Wound-healing assay was performed to study the cell motility. Analysis of RhoA activation in living cells was conducted using RhoA biosensor...
2016: Cancer Cell International
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