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Cancer Cell International

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https://www.readbyqxmd.com/read/28077929/hnrnpa2b1-regulates-the-epithelial-mesenchymal-transition-in-pancreatic-cancer-cells-through-the-erk-snail-signalling-pathway
#1
Shengjie Dai, Jie Zhang, Shihao Huang, Bin Lou, Binbo Fang, Tingting Ye, Xince Huang, Bicheng Chen, Mengtao Zhou
BACKGROUND: Heterogeneous nuclear ribonucleoprotein A2B1 (HNRNPA2B1) is closely related to tumour occurrence and development, oncogene expression, apoptosis inhibition and invasion and metastasis capacities. However, its function in the epithelial-mesenchymal transition (EMT) of pancreatic cancer is not fully understood. METHODS: By comparing various wild-type pancreatic cancer cell lines, we determined which have a higher expression level of HNRNPA2B1 accompanied by the higher expression of N-cadherin and vimentin and lower expression of E-cadherin...
2017: Cancer Cell International
https://www.readbyqxmd.com/read/28074086/role-of-cyp2e1-polymorphisms-in-breast-cancer-a-systematic-review-and-meta-analysis
#2
Yu Lu, Xuan Zhu, Cuiping Zhang, Kongmei Jiang, Chunni Huang, Xue Qin
BACKGROUND: CYP2E1 polymorphisms have been reported to influence individual's breast cancer susceptibility as a phase I enzyme, but the results of these previous studies remain controversial. We performed a comprehensive meta-analysis to assess their association. METHODS: A comprehensive search of literature included in various databases (PubMed, Web of Science and Google scholar), published before August 2016, was performed. Odds ratios (ORs) with 95% confidence intervals (CIs) calculated in fixed or random-effects models were used to estimate the strength of the associations between three polymorphisms of CYP2E1 and breast cancer susceptibility...
2017: Cancer Cell International
https://www.readbyqxmd.com/read/28074085/erratum-to-in-vivo-enhancement-of-the-mage-specific-cellular-immune-response-by-a-recombinant-mage1-mage3-tbhsp70-tumor-vaccine
#3
Wang Junwei, Zhang Xiumin, Ye Jing, Yang Shoujing, Li Zengshan
[This corrects the article DOI: 10.1186/s12935-016-0317-2.].
2017: Cancer Cell International
https://www.readbyqxmd.com/read/28070171/casticin-induces-apoptosis-and-g0-g1-cell-cycle-arrest-in-gallbladder-cancer-cells
#4
Xiao-Ling Song, Yun-Jiao Zhang, Xue-Feng Wang, Wen-Jie Zhang, Zheng Wang, Fei Zhang, Yi-Jian Zhang, Jian-Hua Lu, Jia-Wei Mei, Yun-Ping Hu, Lei Chen, Huai-Feng Li, Yuan-Yuan Ye, Ying-Bin Liu, Jun Gu
BACKGROUND: Casticin, the flavonoid extracted from Vitex rotundifolia L, exerts various biological effects, including anti-inflammatory and anti-cancer activity. The aim of this study is to investigate the effects and mechanisms of casticin in human gallbladder cancer cells. METHODS: Human NOZ and SGC996 cells were used to perform the experiments. CCK-8 assay and colony formation assay were performed to evaluate cell viability. Cell cycle analyses and annexin V/PI staining assay for apoptosis were measured using flow cytometry...
2017: Cancer Cell International
https://www.readbyqxmd.com/read/28070170/the-prognostic-role-of-the-cancer-stem-cell-marker-cd44-in-ovarian-cancer-a-meta-analysis
#5
Jiaying Lin, Ding Ding
BACKGROUND: CD44 has recently been reported as a cancer stem cell marker in ovarian cancer. However, the clinicopathological and prognostic value of this marker in ovarian cancer remains controversial; Here, we aimed to investigate the correlation between CD44 expression and the clinicopathological features or survival of ovarian cancer patients. METHODS: An extensive literature search in the PubMed, EMBASE, and Wanfang databases (up to June 1, 2016) was conducted to identify studies that assessed the clinical or prognostic significance of CD44 expression in ovarian cancer...
2017: Cancer Cell International
https://www.readbyqxmd.com/read/28070169/overexpression-of-trefoil-factor-3-tff3-contributes-to-the-malignant-progression-in-cervical-cancer-cells
#6
Zhaohu Yuan, Dandan Chen, Xiaojie Chen, Huikuan Yang, Yaming Wei
BACKGROUND: There remains a great need for effective therapies for cervical cancers, the majority of which are aggressive leaving patients with poor prognosis. METHODS AND RESULTS: Here, we identify a novel candidate therapeutic target, trefoil factor 3 (TFF3) which overexpressed in cervical cancer cells and was associated with reduced postoperative survival. Functional studies demonstrated that TFF3 overexpression promoted the proliferation and invasion of cervical cancer cells, and inhibited the apoptosis by inducing the mRNA changes in SiHa and Hela cell lines...
2017: Cancer Cell International
https://www.readbyqxmd.com/read/28070168/circulating-tumor-microemboli-ctm-and-vimentin-circulating-tumor-cells-ctcs-detected-by-a-size-based-platform-predict-worse-prognosis-in-advanced-colorectal-cancer-patients-during-chemotherapy
#7
Dejun Zhang, Lei Zhao, Pengfei Zhou, Hong Ma, Fang Huang, Min Jin, Xiaomeng Dai, Xiumei Zheng, Shaoyi Huang, Tao Zhang
BACKGROUND: Circulating tumor cells (CTCs) detected in peripheral blood (PB) of cancer patients can be identified as isolated CTCs and circulating tumor microemboli (CTM). This study aimed to evaluate the prognostic value of CTM detection and CTC phenotype in advanced colorectal cancer (CRC) patients during chemotherapy. METHODS: A size-based platform for CTC isolation was applied. PB samples (5 ml) from 98 advanced CRC patients during 2-6 cycles chemotherapy were collected for CTC detection, and CTC count was correlated to patient's clinicopathological characteristics and clinical outcome...
2017: Cancer Cell International
https://www.readbyqxmd.com/read/28053600/alginate-embedded-huh-7-cells-increase-mmp-9-and-reduce-ocln-expression-in-vitro
#8
Virginia Andrea Angiolini, Carolina Uribe Cruz, Mónica Luján López, Laura Simon, Ursula Matte
BACKGROUND: Hepatocellular carcinoma is a common cancer, ranking third in cancer-associated deaths. An important cause of cancer patients' mortality is metastasis. At the start of metastasis progression, there is an epithelial-mesenchymal transition, characterized by matrix degradation, junction reductions and vessels formation. HuH-7 is a cell line used in research as an in vitro model for hepatocellular carcinoma. It is known that two-dimensional growth reflects tumor characteristics poorly...
2017: Cancer Cell International
https://www.readbyqxmd.com/read/28053599/anticancer-properties-of-ester-derivatives-of-betulin-in-human-metastatic-melanoma-cells-me-45
#9
Małgorzata Drąg-Zalesińska, Marcin Drąg, Marcin Poręba, Sylwia Borska, Julita Kulbacka, Jolanta Saczko
BACKGROUND: Betulinic acid and betulin are triterpenes that have anticancer properties in various types of cancer. Unfortunately, the bioavailability and the bio-distribution of betulinic acid and its metabolic precursor, betulin are very low because of poor solubility in aqueous buffers. METHODS: In this study, we examined the anticancer properties of the ester derivatives of betulin compared to their precursors in a malignant melanoma cell line. We assessed five amino acid esters of betulin...
2017: Cancer Cell International
https://www.readbyqxmd.com/read/28053598/regulation-of-the-hypoxic-tumor-environment-in-hepatocellular-carcinoma-using-rna-interference
#10
REVIEW
Sung Hoon Choi, Jun Yong Park
OBJECTIVES: Hypoxia is the condition where tumor cells have been deprived of oxygen and has been shown to have a role of tumor development in the hepatocellular carcinoma (HCC). METHODS: Using PubMed online database and Google scholar web site, the terms "angiogenesis", "apoptosis", "RNA interference" and/or "hepatocellular carcinoma (HCC)" were searched and analyzed. RESULTS: The hypoxia inducible factors (HIFs) are transcriptional regulators that affect a homeostatic response to oxidative stress and have been identified as a key transcription activator of angiogenesis, survival, and metabolism...
2017: Cancer Cell International
https://www.readbyqxmd.com/read/28053597/mir-324-3p-suppresses-migration-and-invasion-by-targeting-wnt2b-in-nasopharyngeal-carcinoma
#11
Chao Liu, Guo Li, Nianting Yang, Zhongwu Su, Shuiting Zhang, Tengbo Deng, Shuling Ren, Shanhong Lu, Yongquan Tian, Yong Liu, Yuanzheng Qiu
BACKGROUND: Nasopharyngeal carcinoma (NPC) is a malignant epithelial carcinoma of the head and neck with strong ability of invasion and metastasis. Our previous study indicated that miR-324-3p, as a tumor-suppressive factor, could regulate radioresistance of NPC cells by targeting WNT2B. The purpose of this study is to investigate the role of miR-324-3p on migration and invasion in NPC cells. METHODS: Quantitative real time PCR was applied to measure the expression level of miR-324-3p and WNT2B mRNA in both cells and tissues, and the expression level of WNT2B protein was determined by western blotting...
2017: Cancer Cell International
https://www.readbyqxmd.com/read/28053596/celecoxib-enhances-anticancer-effect-of-cisplatin-and-induces-anoikis-in-osteosarcoma-via-pi3k-akt-pathway
#12
Bing Liu, Shigui Yan, Liyan Qu, Jian Zhu
BACKGROUND: COX-2, an inducible enzyme, is associated with inflammatory diseases and carcinogenesis. Overexpression of COX-2 occurs in many human malignancies, including osteosarcoma. COX-2 positivity is form 67 to 92% in osteosarcoma, and COX-2 expresses 141-fold more in cancer stem cell spheres than daughter adherent cells. In our study, we have reported that celecoxib, a cyclooxygenase-2 inhibitor, induces apoptosis in human osteosarcoma cell line MG-63 via down-regulation of PI3K/Akt...
2017: Cancer Cell International
https://www.readbyqxmd.com/read/27980456/autophagy-induced-by-a-sulphamoylated-estrone-analogue-contributes-to-its-cytotoxic-effect-on-breast-cancer-cells
#13
Marcel Verwey, Elsie M Nolte, Anna M Joubert, Anne E Theron
BACKGROUND: Autophagy can either be protective and confer survival to stressed cells, or it can contribute to cell death. The antimitotic drug 2-ethyl-3-O-sulpamoyl-estra-1,3,5(10),15-tetraen-17-ol (ESE-15-ol) is an in silico-designed 17-β-estradiol analogue that induces both autophagy and apoptosis in cancer cells. The aim of the study was to determine the role of autophagy in ESE-15-ol-exposed human adenocarcinoma breast cancer cells; knowledge that will contribute to future clinical applications of this novel antimitotic compound...
2016: Cancer Cell International
https://www.readbyqxmd.com/read/27980455/inhibition-of-integrin-%C3%AE-3-a-binding-partner-of-kallistatin-leads-to-reduced-viability-invasion-and-proliferation-in-nci-h446-cells
#14
Guoquan Wang, Xiao Wang, Xiaoping Huang, Huiyong Yang, Suqiu Pang, Xiaolan Xie, Shulan Zeng, Junsheng Lin, Yong Diao
BACKGROUND: Kallistatin is a serine proteinase inhibitor and heparin-binding protein. It is considered an endogenous angiogenic inhibitor. In addition, multiple studies demonstrated that kallistatin directly inhibits cancer cell growth. However, the molecular mechanisms underlying these effects remain unclear. METHODS: Pull-down, immunoprecipitation, and immunoblotting were used for binding experiments. To elucidate the mechanisms, integrin β3 knockdown (siRNA) or blockage (antibody treatment) on the cell surface of small the cell lung cancer NCI-H446 cell line was used...
2016: Cancer Cell International
https://www.readbyqxmd.com/read/27980454/comprehensive-analysis-of-the-long-noncoding-rna-hoxa11-as-gene-interaction-regulatory-network-in-nsclc-cells
#15
Yu Zhang, Rong-Quan He, Yi-Wu Dang, Xiu-Ling Zhang, Xiao Wang, Su-Ning Huang, Wen-Ting Huang, Meng-Tong Jiang, Xiao-Ning Gan, You Xie, Ping Li, Dian-Zhong Luo, Gang Chen, Ting-Qing Gan
BACKGROUND: Long noncoding RNAs (lncRNAs) are related to different biological processes in non-small cell lung cancer (NSCLC). However, the possible molecular mechanisms underlying the effects of the long noncoding RNA HOXA11-AS (HOXA11 antisense RNA) in NSCLC are unknown. METHODS: HOXA11-AS was knocked down in the NSCLC A549 cell line and a high throughput microarray assay was applied to detect changes in the gene profiles of the A549 cells. Bioinformatics analyses (gene ontology (GO), pathway, Kyoto Encyclopedia of Genes and Genomes (KEGG), and network analyses) were performed to investigate the potential pathways and networks of the differentially expressed genes...
2016: Cancer Cell International
https://www.readbyqxmd.com/read/27895530/alpha-synuclein-contributes-to-malignant-progression-of-human-meningioma-via-the-akt-mtor-pathway
#16
Yiqin Ge, Kan Xu
BACKGROUND: The aim of this study is to explore the expression of alpha-synuclein (α-synuclein) in benign, atypical, and anaplastic meningiomas and determine its role in the malignant progression of meningiomas. METHODS: Expression of α-synuclein was measured in 44 meningioma samples by real-time PCR analysis. The effects of overexpression or knockdown of α-synuclein on meningioma cell growth, invasiveness, and tumorigenicity were determined. RESULTS: Atypical and anaplastic meningiomas displayed significantly greater levels of α-synuclein mRNA, relative to benign tumors...
2016: Cancer Cell International
https://www.readbyqxmd.com/read/27891063/cell-division-cycle-7-kinase-inhibitor-pha-767491-hydrochloride-suppresses-glioblastoma-growth-and-invasiveness
#17
Zubeyde Erbayraktar, Begum Alural, Resat Serhat Erbayraktar, Erdogan Pekcan Erkan
BACKGROUND: Genomic instability is a hallmark of cancer cells, and this cellular phenomenon can emerge as a result of replicative stress. It is possible to take advantage of replicative stress, and enhance it in a targeted way to fight cancer cells. One of such strategies involves targeting the cell division cycle 7-related protein kinase (CDC7), a protein with key roles in regulation of initiation of DNA replication. CDC7 overexpression is present in different cancers, and small molecule inhibitors of the CDC7 have well-documented anti-tumor effects...
2016: Cancer Cell International
https://www.readbyqxmd.com/read/27872579/simultaneous-dual-targeting-of-par-4-and-g6pd-a-promising-new-approach-in-cancer-therapy-quintessence-of-a-literature-review-on-survival-requirements-of-tumor-cells
#18
Ingeborg Elisabeth Cernaj
: The aim of this hypothesis is to propose a new approach in targeted therapy of cancer: The simultaneous, dual targeting of two single molecules, Par-4 and G6PD, rather than inhibition of full-length signaling pathways. RATIONALE: Targeted inhibition of especially two survival signaling pathways (PI3K/AKT/mTOR and MAPK/ERK) is frequently tried, however, a major breakthrough has not yet been reported. Inhibition of complete pathways naturally goes along with a variety of dose-limiting side effects thus contributing to poor efficacy of the administered drugs...
2016: Cancer Cell International
https://www.readbyqxmd.com/read/27843412/overexpression-of-a613t-and-g462t-variants-of-dna-polymerase-%C3%AE-weakens-chemotherapy-sensitivity-in-esophageal-cancer-cell-lines
#19
Yuanyuan Wang, Xiaonan Chen, Qianqian Sun, Wenqiao Zang, Min Li, Ziming Dong, Guoqiang Zhao
BACKGROUND: Human DNA polymerase β (polβ) is a small monomeric protein that is essential for short-patch base excision repair. It plays an important role in regulating the sensitivity of tumor cells to chemotherapy. METHODS: We evaluated the mutation of polβ in a larger cohort of esophageal cancer (EC) patients by RT-PCR and sequencing analysis. The function of the mutation was evaluated by CCK-8, in vivo tumor growth, and flow cytometry assays. RESULTS: There are 229 patients with the polβ mutation, 18 patients with A613T mutation, 12 patients with G462T mutation among 538 ECs...
2016: Cancer Cell International
https://www.readbyqxmd.com/read/27822140/retraction-note-down-regulation-of-mir-133a-and-mir-539-are-associated-with-unfavorable-prognosis-in-patients-suffering-from-osteosarcoma
#20
Alireza Mirghasemi, Afshin Taheriazam, Seyyed Hasan Karbasy, Ali Torkaman, Mohammadreza Shakeri, Emad Yahaghi, Aram Mokarizadeh
[This retracts the article DOI: 10.1186/s12935-015-0237-6.].
2016: Cancer Cell International
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