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Cancer Cell International

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https://www.readbyqxmd.com/read/30636933/crispr-cas9-a-boon-or-bane-the-bumpy-road-ahead-to-cancer-therapeutics
#1
REVIEW
Debarati Ghosh, Prabhadevi Venkataramani, Saikat Nandi, Sonali Bhattacharjee
Genome editing allows for the precise manipulation of DNA sequences in a cell making this technology essential for understanding gene function. CRISPR/Cas9 is a targeted genome-editing platform derived from bacterial adaptive immune system and has been repurposed into a genome-editing tool. The RNA-guided DNA endonuclease, Cas9 can be easily programmed to target new sites by altering its guide RNA sequence, making this technology easier, more efficient, scalable and an indispensable tool in biological research...
2019: Cancer Cell International
https://www.readbyqxmd.com/read/30636932/genetic-polymorphisms-of-estrogen-receptor-genes-are-associated-with-breast-cancer-susceptibility-in-chinese-women
#2
Zhijun Dai, Tian Tian, Meng Wang, Tielin Yang, Hongtao Li, Shuai Lin, Qian Hao, Peng Xu, Yujiao Deng, Linghui Zhou, Na Li, Yan Diao
Background: Estrogen exposure is a widely known risk factor for BC. And the interaction of estrogen with estrogen receptor (ER) plays an important role in breast cancer development. This case-control study aims to assess the association of genetic polymorphisms in the estrogen receptor genes with breast cancer (BC) susceptibility in Chinese Han women. Methods: Four polymorphisms (rs2881766, rs9383951, rs9340799 in ESR1 and rs3020449 in ESR2 ) were genotyped in 459 patients and 549 healthy controls using the Sequenom MassARRAY method...
2019: Cancer Cell International
https://www.readbyqxmd.com/read/30636931/markers-of-mek-inhibitor-resistance-in-low-grade-serous-ovarian-cancer-egfr-is-a-potential-therapeutic-target
#3
Marta Llaurado Fernandez, Amy Dawson, Joshua Hoenisch, Hannah Kim, Sylvia Bamford, Clara Salamanca, Gabriel DiMattia, Trevor Shepherd, Mattia Cremona, Bryan Hennessy, Shawn Anderson, Stanislav Volik, Colin C Collins, David G Huntsman, Mark S Carey
Background: Although low-grade serous ovarian cancer (LGSC) is rare, case-fatality rates are high as most patients present with advanced disease and current cytotoxic therapies are not overly effective. Recognizing that these cancers may be driven by MAPK pathway activation, MEK inhibitors (MEKi) are being tested in clinical trials. LGSC respond to MEKi only in a subgroup of patients, so predictive biomarkers and better therapies will be needed. Methods: We evaluated a number of patient-derived LGSC cell lines, previously classified according to their MEKi sensitivity...
2019: Cancer Cell International
https://www.readbyqxmd.com/read/30636930/overexpression-of-cd59-inhibits-apoptosis-of-t-acute-lymphoblastic-leukemia-via-akt-notch1-signaling-pathway
#4
Yanfei Jia, Yan Qi, Yunshan Wang, Xiaoli Ma, Yihui Xu, Jun Wang, Xiaoqian Zhang, Meihua Gao, Beibei Cong, Shuyi Han
Background: T-acute lymphoblastic leukemia (T-ALL) was a hematological malignancy characterized by the accumulation of immature T cells in bone marrow and peripheral blood. In this study, we tried to explore the physiological role of CD59 in T-ALL. Methods: In this study, we collected the bone marrow samples from 17 T-ALL patients and 38 healthy participants to find differences in CD59 expression patterns. Then, CD59 was over-expressed in T-ALL cell line Jurkat, and its biological functions were detected...
2019: Cancer Cell International
https://www.readbyqxmd.com/read/30636929/overexpression-of-chloride-channel-3-clc-3-is-associated-with-human-cervical-carcinoma-development-and-prognosis
#5
Yu-Tao Guan, Yong Xie, Hui Zhou, Hai-Yan Shi, Yu-Yuan Zhu, Xiao-Lu Zhang, Yi Luan, Xi-Ming Shen, Yang-Ping Chen, Li-Jiang Xu, Zhong-Qiu Lin, Gang Wang
Background: Cervical carcinoma is a major gynecological cancer and causes cancer-related deaths in worldwide, the latent pathogenesis and progress of cervical cancer is still under research. ClC-3 may be an important promoter for aggressive metastasis of malignant tumors. In this research, we explore the ClC-3 expression in cervical carcinoma and its underlying clinical significance, trying to illuminate ClC-3 probable function in the neoplasm malignant behavior, development and prognosis...
2019: Cancer Cell International
https://www.readbyqxmd.com/read/30627053/gambogic-acid-induces-autophagy-and-combines-synergistically-with-chloroquine-to-suppress-pancreatic-cancer-by-increasing-the-accumulation-of-reactive-oxygen-species
#6
Hongcheng Wang, Zhi Zhao, Shizhou Lei, Shaoli Li, Zhen Xiang, Xiaoyu Wang, Xiuyan Huang, Guanggai Xia, Xinyu Huang
Background: Gambogic acid is a natural component isolated from gamboge that possesses anticancer properties. Our previous study suggested that gambogic acid might be involved in autophagy; however, its role in pancreatic cancer remained unclear. Methods: Cell viability and apoptosis of pancreatic cancer cell lines were determined using (4,5-dimethylthiazol-2-yl)-3,5-diphenylformazan and flow cytometry. The effects of gambogic acid on autophagy was assessed by western blot, acridine orange staining, transmission electron microscopy, and measurement of autophagic flux through RFP-GFP-LC3 lentiviral transfection...
2019: Cancer Cell International
https://www.readbyqxmd.com/read/30627052/identification-of-a-6-gene-signature-predicting-prognosis-for-colorectal-cancer
#7
Shuguang Zuo, Gongpeng Dai, Xuequn Ren
Background: An accurate and robust gene signature is of the utmost importance in assisting oncologists to make a more accurate evaluation in clinical practice. In our study, we extracted key mRNAs significantly related to colorectal cancer (CRC) prognosis and we constructed an expression-based gene signature to predict CRC patients' survival. Methods: mRNA expression profiles and clinicopathological data of colon adenocarcinoma (COAD) cases and rectum adenocarcinoma (READ) were collected from The Cancer Genome Atlas database to investigate gene expression alteration associated to the prognosis of CRC...
2019: Cancer Cell International
https://www.readbyqxmd.com/read/30622441/relationship-between-the-upregulation-of-notch1-signaling-and-the-clinical-characteristics-of-patients-with-papillary-thyroid-carcinoma-in-east-asia-a-systematic-review-and-meta-analysis
#8
Libing Yuan, Lei Ma, Haibo Xue, Shoujun Song
Background: Many studies have aimed to clarify the relationship between Notch1 signaling and papillary thyroid carcinoma (PTC), but the results have been inconsistent to date. In the present study, a systematic review and meta-analysis were performed to analyze the relationship between Notch1 signaling and the clinical characteristics of PTC. Methods: Literature databases, including PubMed (Medline), Embase and China National Knowledge Infrastructure, were searched for relevant studies from inception to April 2018...
2019: Cancer Cell International
https://www.readbyqxmd.com/read/30622440/senp1-mediated-desumoylation-of-usp28-regulated-hif-1%C3%AE-accumulation-and-activation-during-hypoxia-response
#9
Shi-Chun Du, Lan Zhu, Yu-Xing Wang, Jie Liu, Die Zhang, Yu-Lu Chen, Qing Peng, Wei Liu, Bin Liu
Background: The ubiquitin-specific protease 28 (USP28) is an oncogenic deubiquitinase, which plays a critical role in tumorigenesis via antagonizing the ubiquitination and degradation of tumor suppressor protein FBXW7-mediated oncogenic substrates. USP28 controls hypoxia-dependent angiogenesis and metastasis by preventing FBXW7-dependent hypoxia-inducible transcription factor-1α (HIF-1α) degradation during hypoxia. However, it remains unclear how USP28 activation and HIF-1α signaling are coordinated in response to hypoxia...
2019: Cancer Cell International
https://www.readbyqxmd.com/read/30622439/hoxb8-enhances-the-proliferation-and-metastasis-of-colorectal-cancer-cells-by-promoting-emt-via-stat3-activation
#10
Tingting Wang, Feiyan Lin, Xuecheng Sun, Lei Jiang, Ruibo Mao, Shenyue Zhou, Wenjing Shang, Ruichun Bi, Fengying Lu, Shaotang Li
Background: Previous studies have demonstrated that the expression of homeobox8 (HOXB8) is higher in colorectal cancer (CRC) tissues than in normal tissues; however, the precise role of HOXB8 in human CRC cells remains to be elucidated. Methods: We generated lentiviral constructs to overexpress and silence HOXB8 in CRC cell lines, and examined their biological functions through MTT, wound healing, colony and transwell, expression of signal transducer and activator of transcription 3 (STAT3) and epithelial-mesenchymal transition (EMT) related factors through western-blot...
2019: Cancer Cell International
https://www.readbyqxmd.com/read/30622438/t-cell-receptor-engineered-t-cells-for-leukemia-immunotherapy
#11
REVIEW
Yikai Zhang, Yangqiu Li
At present, refractory and relapse are major issues for leukemia therapy and a major cause of allogeneic hematopoietic stem cell transplant failure. Over the last decade, many studies have demonstrated that adoptive cancer antigen-specific T cell therapy is an effective option for leukemia therapy. Recently, T cell immunotherapy studies have mainly focused on chimeric antigen receptor- and T cell receptor-engineered T cells. Clinical trials involving chimeric antigen receptor-engineered T cells have been a major breakthrough and became a novel therapy for leukemia...
2019: Cancer Cell International
https://www.readbyqxmd.com/read/30622437/novel-sulphamoylated-2-methoxy-estradiol-derivatives-inhibit-breast-cancer-migration-by-disrupting-microtubule-turnover-and-organization
#12
Rustelle Janse van Vuuren, Mandie Botes, Tamarin Jurgens, Anna Margaretha Joubert, Iman van den Bout
Background: The estrogen metabolite 2-methoxyestradiol (2ME2) and a number of synthesised derivatives have been shown to bind to microtubules thereby arresting cancer cells in mitosis which leads to apoptosis. In interphase cells, microtubules play an important role in the delivery of proteins to subcellular locations including the focal adhesions. In fact, focal adhesion dynamics and cell migration are in part regulated by microtubules. We hypothesised that novel 2ME2 derivatives can alter cell migration by influencing microtubule dynamics in interphase cells...
2019: Cancer Cell International
https://www.readbyqxmd.com/read/30618491/an-actin-binding-protein-espn-is-an-independent-prognosticator-and-regulates-cell-growth-for-esophageal-squamous-cell-carcinoma
#13
Shau-Hsuan Li, Hung-I Lu, Wan-Ting Huang, Yen-Hao Chen, Chien-Ming Lo, Ya-Chun Lan, Wei-Che Lin, Hsin-Ting Tsai, Chang-Han Chen
Background: ESPN (Espin), an actin filament-binding protein, plays an important role in regulating the organization, dimensions, dynamics, and signaling capacities of the actin filament-rich, microvillus-type specializations that mediate sensory transduction in various mechanosensory and chemosensory cells. Recent few studies show that ESPN regulates metastasis and cell proliferation in melanoma. However, the significance of ESPN in other cancers such as esophageal squamous cell carcinoma (ESCC) remains largely unknown...
2018: Cancer Cell International
https://www.readbyqxmd.com/read/30607140/analysis-of-pd-1-related-immune-transcriptional-profile-in-different-cancer-types
#14
Jun Shang, Qian Song, Zuyi Yang, Xiaoyan Sun, Meijuan Xue, Wenjie Chen, Jingcheng Yang, Sihua Wang
Background: Programmed cell death 1 (PD-1) functions as an immune checkpoint in the process of anti-tumor immune response. The PD-1 blockade is now becoming a fundamental part in cancer immunotherapy. So it's essential to elicit the PD-1 related immune process in different types of cancer. Methods: The Cancer Genome Atlas was used to collect the RNA-seq data of 33 cancer types. The microenvironment cell populations-counter was used to analyze the immune cell infiltrates...
2018: Cancer Cell International
https://www.readbyqxmd.com/read/30607139/speckle-type-poz-protein-functions-as-a-tumor-suppressor-in-non-small-cell-lung-cancer-due-to-dna-methylation
#15
Sumei Yao, Xinming Chen, Jinliang Chen, Yangbo Guan, Yifei Liu, Jianrong Chen, Xuedong Lv
Background: Tumor suppressor epigenetic silencing plays an important role in non-small cell lung cancer (NSCLC) development and progression. Previously, the expression of speckle-type POZ protein (SPOP) has been found to be significantly inhibited in NSCLC. Our research aimed to investigate the molecular mechanisms, clinical significance and epigenetic alteration of SPOP in NSCLC. Materials and methods: Bisulfite sequencing PCR and methylation-specific PCR were performed to test gene methylation...
2018: Cancer Cell International
https://www.readbyqxmd.com/read/30602942/immunohistochemical-investigation-of-prognostic-biomarkers-in-resected-colorectal-liver-metastases-a-systematic-review-and-meta-analysis
#16
REVIEW
William Torén, Daniel Ansari, Roland Andersson
Background: Many studies have investigated the prognostic role of biomarkers in colorectal liver metastases (CRLM). However, no biomarker has been established in routine clinical practice. The aim of this study was to scrutinize the current literature for biomarkers evaluated by immunohistochemistry as prognostic markers in patients with resected CRLM. Methods: A systematic review was performed according to the PRISMA guidelines. Articles were identified in the PubMed database with selected search terms and by cross-references search...
2018: Cancer Cell International
https://www.readbyqxmd.com/read/30598641/neuropeptide-induced-modulation-of-carcinogenesis-in-a-metastatic-breast-cancer-cell-line-mda-mb-231-luc
#17
Silvia Gutierrez, M Danilo Boada
Background: Metastatic cancer to bone is well-known to produce extreme pain. It has been suggested that the magnitude of this perceived pain is associated with disease progression and poor prognosis. These data suggest a potential cross-talk between cancer cells and nociceptors that contribute not only to pain, but also to cancer aggressiveness although the underlying mechanisms are yet to be stablished. Methods: The in vitro dose dependent effect of neuropeptides (NPs) (substance P [SP], calcitonin gene-related peptide and neurokinin A [NKA]) and/or its combination, on the migration and invasion of MDA-MB-231LUC+ were assessed by wound healing and collagen-based cell invasion assays, respectively...
2018: Cancer Cell International
https://www.readbyqxmd.com/read/30598640/next-generation-sequencing-based-genetic-landscape-and-its-clinical-implications-for-chinese-acute-myeloid-leukemia-patients
#18
Xin-Xin Cao, Hao Cai, Yue-Ying Mao, Qi Wu, Lu Zhang, Dao-Bin Zhou, Jian Li
Background: Acute myeloid leukemia (AML) is a clinically and biologically heterogeneous disease. The survival of older patients is generally poor. In the current study, we sought to investigate the differences in molecular gene mutations between younger and older AML patients, and to identify those newly diagnosed AML patients who are more likely to respond to standard cytarabine and daunorubicin induction chemotherapy. Methods: We retrospectively evaluated 179 patients who were newly diagnosed with non-M3 AML...
2018: Cancer Cell International
https://www.readbyqxmd.com/read/30598639/analysis-of-dynamic-molecular-networks-for-pancreatic-ductal-adenocarcinoma-progression
#19
Zongfu Pan, Lu Li, Qilu Fang, Yiwen Zhang, Xiaoping Hu, Yangyang Qian, Ping Huang
Background: Pancreatic ductal adenocarcinoma (PDAC) is one of the deadliest solid tumors. The rapid progression of PDAC results in an advanced stage of patients when diagnosed. However, the dynamic molecular mechanism underlying PDAC progression remains far from clear. Methods: The microarray GSE62165 containing PDAC staging samples was obtained from Gene Expression Omnibus and the differentially expressed genes (DEGs) between normal tissue and PDAC of different stages were profiled using R software, respectively...
2018: Cancer Cell International
https://www.readbyqxmd.com/read/30574021/prognostic-significance-of-cxcr7-in-cancer-patients-a-meta-analysis
#20
Huiqian Fan, Weijun Wang, Jingjing Yan, Li Xiao, Ling Yang
Background: CXC chemokine receptor 7 (CXCR7) is frequently overexpressed in a variety of tumors. Nevertheless, whether CXCR7 can be used as a tumor prognosis marker has not been systematically assessed. The current meta-analysis was performed to obtain an accurate evaluation of the relationship between CXCR7 level and the prognosis of cancer patients. Methods: Embase, Web of Science, and PubMed were systematically searched according to a defined search strategy up to June 11, 2018...
2018: Cancer Cell International
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