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Cancer Cell International

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https://www.readbyqxmd.com/read/28546788/dmd-transcripts-in-crl-2061-rhabdomyosarcoma-cells-show-high-levels-of-intron-retention-by-intron-specific-pcr-amplification
#1
Emma Tabe Eko Niba, Ryo Yamanaka, Abdul Qawee Mahyoob Rani, Hiroyuki Awano, Masaaki Matsumoto, Hisahide Nishio, Masafumi Matsuo
BACKGROUND: The DMD gene encoding dystrophin is mutated in Duchenne muscular dystrophy, a fatal progressive muscle wasting disease. DMD has also been shown to act as a tumor suppressor gene. Rhabdomyosarcoma (RMS) is a mesodermal sarcoma that shares characteristics of skeletal muscle precursors. Products of the DMD gene in RMS have not yet been fully clarified. Here, DMD products were analyzed in CRL-2061 cells established from alveolar RMS. METHODS: The 14-kb long DMD cDNA was PCR amplified as 20 separated fragments, as were nine short intron regions...
2017: Cancer Cell International
https://www.readbyqxmd.com/read/28546787/pepsinogen-c-expression-regulation-and-its-relationship-with-cancer
#2
REVIEW
Shixuan Shen, Jingyi Jiang, Yuan Yuan
Pepsinogen C (PGC) belongs to the aspartic protease family and is secreted by gastric chief cells. PGC could be activated to pepsin C and digests polypeptides and amino acids, but as a zymogen PGC's functions is unclear. In normal physiological conditions, PGC is initially detected in the late embryonic stage and is mainly expressed in gastric mucosa. The in situ expression of PGC in gastric mucosa is decreased considerably in the process of superficial gastritis → atrophic gastritis → gastric cancer (GC), proving that PGC is a comparatively ideal negative marker of GC...
2017: Cancer Cell International
https://www.readbyqxmd.com/read/28533703/differential-expression-of-vegfr2-protein-in-her2-positive-primary-human-breast-cancer-potential-relevance-to-anti-angiogenic-therapies
#3
Aejaz Nasir, Timothy R Holzer, Mia Chen, Michael Z Man, Andrew E Schade
BACKGROUND: Clinically relevant predictive biomarkers to tailor anti-angiogenic therapies to breast cancer (BRC) patient subpopulations are an unmet need. METHODS: We analyzed tumor vascular density and VEGFR2 protein expression in various subsets of primary human BRCs (186 females; Mean age: 59 years; range 33-88 years), using a tissue microarray. Discrete VEGFR2+ and CD34+ tumor vessels were manually scored in invasive ductal, lobular, mixed ductal-lobular and colloid (N = 139, 22, 18, 7) BRC cores...
2017: Cancer Cell International
https://www.readbyqxmd.com/read/28515673/growth-of-mcf-7-breast-cancer-cells-and-efficacy-of-anti-angiogenic-agents-in-a-hydroxyethyl-chitosan-glycidyl-methacrylate-hydrogel
#4
Hejing Wang, Junmin Qian, Yaping Zhang, Weijun Xu, Juxiang Xiao, Aili Suo
BACKGROUND: Breast cancer negatively affects women's health worldwide. The tumour microenvironment plays a critical role in tumour initiation, proliferation, and metastasis. Cancer cells are traditionally grown in two-dimensional (2D) cultures as monolayers on a flat solid surface lacking cell-cell and cell-matrix interactions. These experimental conditions deviate from the clinical situation. Improved experimental systems that can mimic the in vivo situation are required to discover new therapies, particularly for anti-angiogenic agents that mainly target intercellular factors and play an essential role in treating some cancers...
2017: Cancer Cell International
https://www.readbyqxmd.com/read/28507454/hypoxia-and-tgf-%C3%AE-1-induced-plod2-expression-improve-the-migration-and-invasion-of-cervical-cancer-cells-by-promoting-epithelial-to-mesenchymal-transition-emt-and-focal-adhesion-formation
#5
Feifei Xu, Jialu Zhang, Guolin Hu, Lei Liu, Weijiang Liang
BACKGROUND: Intra-tumoral hypoxia and increases in extracellular level of transforming growth factor β1 (TGF-β1), which are common findings in cancer, are associated with an increased risk of metastasis and mortality. Moreover, metastasis is the leading cause of death of patients with cervical cancer. PLOD2 is an intracellular enzyme required for the biogenesis of collagen and its expression can be induced by hypoxia and TGF-β1. Specifically, PLOD2 is up-regulated in several types of cancer, including cervical cancer, and is associated with cancer metastasis...
2017: Cancer Cell International
https://www.readbyqxmd.com/read/28507453/erratum-to-suppression-of-spry4-enhances-cancer-stem-cell-properties-of-human-mda-mb-231-breast-carcinoma-cells
#6
Hongyu Jing, Lucy Liaw, Robert Friesel, Calvin Vary, Shucheng Hua, Xuehui Yang
[This corrects the article DOI: 10.1186/s12935-016-0292-7.].
2017: Cancer Cell International
https://www.readbyqxmd.com/read/28503095/the-cholesterol-metabolite-27-hydroxycholesterol-stimulates-cell-proliferation-via-er%C3%AE-in-prostate-cancer-cells
#7
Shaneabbas Raza, Megan Meyer, Casey Goodyear, Kimberly D P Hammer, Bin Guo, Othman Ghribi
BACKGROUND: For every six men, one will be diagnosed with prostate cancer (PCa) in their lifetime. Estrogen receptors (ERs) are known to play a role in prostate carcinogenesis. However, it is unclear whether the estrogenic effects are mediated by estrogen receptor α (ERα) or estrogen receptor β (ERβ). Although it is speculated that ERα is associated with harmful effects on PCa, the role of ERβ in PCa is still ill-defined. The cholesterol oxidized metabolite 27-hydroxycholesterol (27-OHC) has been found to bind to ERs and act as a selective ER modulator (SERM)...
2017: Cancer Cell International
https://www.readbyqxmd.com/read/28469531/cancer-metastasis-enactment-of-the-script-for-human-reproductive-drama
#8
Xichun Sun, Xiwu Liu
Based on compelling evidence from many biological disciplines, we put forth a hypothesis for cancer metastasis. In the hypothesis, the metastatic cascade is depicted as human reproduction in miniature. Illustrated in a reproductive light, the staggering resemblance of cancer metastasis to human reproduction becomes evident despite some ostensible dis-similarities. In parallel to the appearance of primordial germ cells during early embryogenesis, the cancer reproductive saga starts with the separation of metastasis initiating cells (MICs) from cancer initiating cells when the primary cancer is still in its infancy...
2017: Cancer Cell International
https://www.readbyqxmd.com/read/28465673/secretory-phospholipase-a2-and-fatty-acid-composition-in-oral-reactive-lesions-a-cross-sectional-study
#9
Ali Hossein Mesgarzadeh, Abolfazl Akbarzadeh, Ali Rasipour, Tannaz Rasipour, Amir Mehdizadeh, Maghsod Shaaker
BACKGROUND: Oral reactive lesions are the most common lesions of oral cavity. Phospholipases and fatty acids play key roles in the creation of inflammation by change in metabolic activities and production of lipid mediators. The aim of this study was to investigate the amount of secretory phospholipase-A2 (sPLA2) and difference of fatty acid pattern in oral reactive hyperplasia and adjacent normal appearing tissues in patients with oral reactive lesions. METHODS: Paired samples of oral hyperplastic (OH) and adjacent normal-appearing tissue of 45 patients were investigated in this study...
2017: Cancer Cell International
https://www.readbyqxmd.com/read/28450809/patm-and-%C3%AE-h2ax-are-effective-radiation-biomarkers-in-assessing-the-radiosensitivity-of-12-c-6-in-human-tumor-cells
#10
Jin Zhao, Zhong Guo, Shuyan Pei, Lei Song, Chenjing Wang, Jianxiu Ma, Long Jin, Yanqing Ma, Renke He, Jianbin Zhong, Ying Ma, Hong Zhang
BACKGROUND: Tumour radiosensitivity would be particularly useful in optimizing the radiation dose during radiotherapy. The aim of the current study was to evaluate the potential value of phosphorylated H2AX (γH2AX) and ATM (pATM) in assessing (12)C(6+) radiosensitivity of tumour cells. METHODS: Human cervical carcinoma HeLa cells, hepatoma HepG2 cells, and mucoepidermoid carcinoma MEC-1 cells were irradiated with different doses of (12)C(6+). The survival fraction was assayed with clonogenic survival method and the foci of γH2AX and pATM was visualized using immunocytochemical methods...
2017: Cancer Cell International
https://www.readbyqxmd.com/read/28450808/metformin-exhibits-the-anti-proliferation-and-anti-invasion-effects-in-hepatocellular-carcinoma-cells-after-insufficient-radiofrequency-ablation
#11
Qingyun Zhang, Jian Kong, Shuying Dong, Wenlei Xu, Wenbing Sun
BACKGROUND: The mechanisms and prevention of progression of hepatocellular carcinoma (HCC) after insufficient radiofrequency ablation (RFA) has been preliminarily investigated, therefore, new strategy needs to be investigated to prevent the process. Whether metformin could be used to inhibit the growth of HCC after insufficient RFA and further prevent the progression of residual HCC remains unclearly. METHODS: MTT assay, colony formation assay and transwell assay were used to observe the cell viability, migration and invasion...
2017: Cancer Cell International
https://www.readbyqxmd.com/read/28435405/establishment-and-characterization-of-6-novel-patient-derived-primary-pancreatic-ductal-adenocarcinoma-cell-lines-from-korean-pancreatic-cancer-patients
#12
Mi-Ju Kim, Min-Sun Kim, Sung Joo Kim, Soyeon An, Jin Park, Hosub Park, Jae Hoon Lee, Ki-Byung Song, Dae Wook Hwang, Suhwan Chang, Kyu-Pyo Kim, Seong-Yun Jeong, Song Cheol Kim, Seung-Mo Hong
BACKGROUND: Pancreatic ductal adenocarcinomas are among the most malignant neoplasms and have very poor prognosis. Our understanding of various cancers has recently improved the survival of patients with cancer, except for pancreatic cancers. Establishment of primary cancer cell lines of pancreatic ductal adenocarcinomas will be useful for understanding the molecular mechanisms of this disease. METHODS: Eighty-one surgically resected pancreatic ductal adenocarcinomas were collected...
2017: Cancer Cell International
https://www.readbyqxmd.com/read/28428733/microrna-338-3p-suppresses-cell-proliferation-and-induces-apoptosis-of-non-small-cell-lung-cancer-by-targeting-sphingosine-kinase-2
#13
Guowei Zhang, Hao Zheng, Guojun Zhang, Ruirui Cheng, Chunya Lu, Yijie Guo, Guoqiang Zhao
BACKGROUND: Lung cancer is the major cause of cancer-related death worldwide, and 80% patients of lung cancer are non-small-cell lung cancer (NSCLC) cases. MicroRNAs are important gene regulators with critical roles in diverse biological processes, including tumorigenesis. Studies indicate that sphingosine kinase 2 (SphK2) promotes tumor progression in NSCLC, but how this occurs is unclear. Thus, we explored the effect of miR-338-3p targeting SphK2 on proliferation and apoptosis of NSCLC cells...
2017: Cancer Cell International
https://www.readbyqxmd.com/read/28400705/high-expression-of-rab25-contributes-to-malignant-phenotypes-and-biochemical-recurrence-in-patients-with-prostate-cancer-after-radical-prostatectomy
#14
Chunhui Hu, Beibei Chen, Yibin Zhou, Yuxi Shan
BACKGROUND: Ras-related protein 25 (Rab25) functions either as an oncogene or a tumor suppressor with a cancer type-dependent manner. We aimed to investigate clinical significance of Rab25 in prostate cancer (PCa). METHODS: Quantitative real-time polymerase chain reaction, Western blot and immunohistochemistry were respectively performed to detect Rab25 mRNA and protein expression in PCa and adjacent non-cancerous prostate tissues. Receiver-operating characteristic curve analysis was used to evaluate predictive diagnostic value of Rab25...
2017: Cancer Cell International
https://www.readbyqxmd.com/read/28396617/long-non-coding-rna-malat1-drives-gastric-cancer-progression-by-regulating-hmgb2-modulating-the-mir-1297
#15
Jijun Li, Jinghua Gao, Wen Tian, Yongsheng Li, Jinghua Zhang
BACKGROUND: Emerging evidences have verified that long non-coding RNAs (lncRNAs) play important regulatory roles in the pathogenesis and progression of cancers. lncRNAs metastasis associated lung adenocarcinoma transcript 1 (MALAT1) have been found to be up-regulated in some human cancers. The main objective of this study was to investigate the expression level and biological function of MALAT1 in gastric cancer (GC). METHODS: Quantificational real-time polymerase chain reaction (qRT-PCR) was performed to detect the mRNA levels of MALAT1 in 78 paired gastric carcinoma tissues and adjacent normal tissues, and the associations of MALAT1 expression with the clinicopathological features were analyzed, and the prognosis of gastric carcinoma patients was evaluated...
2017: Cancer Cell International
https://www.readbyqxmd.com/read/28373828/the-synthetic-peptide-cigb-300-modulates-ck2-dependent-signaling-pathways-affecting-the-survival-and-chemoresistance-of-non-small-cell-lung-cancer-cell-lines
#16
Stéfano M Cirigliano, María I Díaz Bessone, Damián E Berardi, Carolina Flumian, Elisa D Bal de Kier Joffé, Silvio E Perea, Hernán G Farina, Laura B Todaro, Alejandro J Urtreger
BACKGROUND: Lung cancer is the most frequently diagnosed cancer and the leading cause of cancer-related deaths worldwide. Up to 80% of cancer patients are classified as non-small-cell lung cancer (NSCLC) and cisplatin remains as the gold standard chemotherapy treatment, despite its limited efficacy due to both intrinsic and acquired resistance. The CK2 is a Ser/Thr kinase overexpressed in various types of cancer, including lung cancer. CIGB-300 is an antitumor peptide with a novel mechanism of action, since it binds to CK2 substrates thus preventing the enzyme activity...
2017: Cancer Cell International
https://www.readbyqxmd.com/read/28367105/mycn-amplification-predicts-poor-prognosis-based-on-interphase-fluorescence-in-situ-hybridization-analysis-of-bone-marrow-cells-in-bone-marrow-metastases-of-neuroblastoma
#17
Zhi-Xia Yue, Cheng Huang, Chao Gao, Tian-Yu Xing, Shu-Guang Liu, Xing-Jun Li, Qian Zhao, Xi-Si Wang, Wen Zhao, Mei Jin, Xiao-Li Ma
BACKGROUND: MYCN gene amplification is related to risk stratification. Therefore it is important to identify accurately the level of the MYCN gene as early as possible in neuroblastoma (NB); however, for patients with bone marrow (BM) metastasis who need chemotherapy before surgery, timely detection of the MYCN gene is not possible due to the unavailability of primary tumors. METHODS: MYCN gene status was evaluated in 81 BM metastases of NB by interphase fluorescence in situ hybridization (FISH) analysis of BM cells...
2017: Cancer Cell International
https://www.readbyqxmd.com/read/28360821/combined-ephb2-receptor-knockdown-with-radiation-decreases-cell-viability-and-invasion-in-medulloblastoma
#18
Shilpa Bhatia, Kellen Hirsch, Sanjana Bukkapatnam, Nimrah A Baig, Ayman Oweida, Anastacia Griego, Dylan Calame, Jaspreet Sharma, Andrew Donson, Nicholas Foreman, Christopher Albanese, Sujatha Venkataraman, Rajeev Vibhakar, Sana D Karam
BACKGROUND: Medulloblastoma is one of the most common types of pediatric brain tumor characterized by the subpopulation of cells that exhibit high invasive potential and radioresistant properties. In addition, dysregulated function and signaling by Eph family of receptors have been shown to impart pro-tumorigenic characteristics in this brain malignancy. In the current study, we investigated whether EphB2 knockdown in combination with radiation can alter invasiveness and decrease medulloblastoma tumor growth or viability in vitro...
2017: Cancer Cell International
https://www.readbyqxmd.com/read/28360820/the-effect-of-tetrandrine-combined-with-cisplatin-on-proliferation-and-apoptosis-of-a549-ddp-cells-and-a549-cells
#19
Ling-Yun Ye, Song Hu, Hua-E Xu, Rong-Rong Xu, Hui Kong, Xiao-Ning Zeng, Wei-Ping Xie, Hong Wang
BACKGROUND: Non-small cell lung cancer comprises the majority of lung cancer cases and is insensitive to chemotherapy. Most patients develop drug resistance. Recently, tetrandrine (TET), a bis-benzylisoquinoline alkaloid, was identified as a novel anti-cancer agent. However, the effect of tetrandrine combined with cisplatin on lung cancer has not yet been studied. We aimed to identify a possible synergistic effect between tetrandrine and cisplatin, besides, to investigate the effects of TET in combination with DDP on proliferation and apoptosis in cisplatin-resistant and cisplatin-sensitive A549 cell lines, and to study the underlying mechanism...
2017: Cancer Cell International
https://www.readbyqxmd.com/read/28293146/rs35301225-polymorphism-in-mir-34a-promotes-development-of-human-colon-cancer-by-deregulation-of-3-utr-in-e2f1-in-chinese-population
#20
Haiqiang Jiang, Fengyuan Ge, Beina Hu, Lamei Wu, Huijian Yang, Huiyun Wang
BACKGROUND: Previous reports have revealed that down-regulation of miR-34a expression can promote colorectal cancer (CRC) cell growth by targeting cell cycle-related transcriptional factor E2F1. To date, the function of the single nucleotide polymorphism (SNP) located in the mature region of miR-34a has not been investigated. METHODS: We performed a case-control study including 685 CRC patients and 618 cancer-free controls. Genotyping, real-time PCR assay, cell transfection, and the dual luciferase reporter assay were used in our study...
2017: Cancer Cell International
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