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Cancer Cell International

Ruonan Xu, Ying Fang, Chunmei Hou, Bing Zhai, Zhenyu Jiang, Ning Ma, Liang Wang, Gencheng Han, Renxi Wang
Background: Both multiple myeloma (MM) and systemic lupus erythematosus (SLE) are associated with abnormal production of plasma cells, although their pathological mechanism of each disease is different. The main characteristic of both diseases is uncontrolled differentiation of B cells into plasmablast/plasma cells. Despite continuous research on prognostic factors and the introduction of new agents for MM and SLE, treatments still do not exist for controlling plasmablast/plasma cells...
2018: Cancer Cell International
Yi Chai, Huan Wang, Fang Zhou
Background: To establish one primary cell line of human liver metastasis of colon cancer. Methods: HCS1220 cell line was derived from one liver metastasis of colon cancer patient's resected tumor sample. The characterization of the cell line was defined by karyotype analysis, short tandem repeat (STR) analysis and mycoplasma contamination. Subcutaneous injection 1 × 106  cells to four BALB/c nude mice, the viable tumors were developed and diagnosed (H&E staining)...
2018: Cancer Cell International
Bianca Maria Scicchitano, Silvia Sorrentino, Gabriella Proietti, Gina Lama, Gabriella Dobrowolny, Angela Catizone, Elena Binda, Luigi Maria Larocca, Gigliola Sica
Background: Glioblastoma multiforme (GBM) is a highly aggressive brain tumor in which cancer cells with stem cell-like features, called cancer stem cells (CSCs), were identified. Two CSC populations have been previously identified in GBM, one derived from the GBM area called enhanced lesion (GCSCs) and the other one from the brain area adjacent to the tumor margin (PCSCs) that greatly differ in their growth properties and tumor-initiating ability. To date the most effective chemotherapy to treat GBM is represented by alkylating agents such as temozolomide (TMZ), whose activity can be regulated by histone deacetylases (HDACs) inhibitors through the modulation of O6-methylguanine-DNA methyltransferase (MGMT) expression...
2018: Cancer Cell International
Evita G Weagel, Weston Burrup, Roman Kovtun, Edwin J Velazquez, Abigail M Felsted, Michelle H Townsend, Zachary E Ence, Erica Suh, Stephen R Piccolo, K Scott Weber, Richard A Robison, Kim L O'Neill
Background: Lung, breast, and colorectal malignancies are the leading cause of cancer-related deaths in the world causing over 2.8 million cancer-related deaths yearly. Despite efforts to improve prevention methods, early detection, and treatments, survival rates for advanced stage lung, breast, and colon cancer remain low, indicating a critical need to identify cancer-specific biomarkers for early detection and treatment. Thymidine kinase 1 (TK1) is a nucleotide salvage pathway enzyme involved in cellular proliferation and considered an important tumor proliferation biomarker in the serum...
2018: Cancer Cell International
Lujun Chen, Jun Feng, Bin Xu, You Zhou, Xiao Zheng, Changping Wu, Jingting Jiang
[This corrects the article DOI: 10.1186/s12935-018-0627-7.].
2018: Cancer Cell International
Faezeh Hosseinzadeh, Javad Verdi, Jafar Ai, Saieh Hajighasemlou, Iman Seyhoun, Frzad Parvizpour, Fatemeh Hosseinzadeh, Abolfazl Iranikhah, Sadegh Shirian
Background: High prevalence of hepatocellular carcinoma (HCC) and typically poor prognosis of this disease that lead to late stage diagnosis when potentially curative therapies are least effective; therefore, development of an effective and systematic treatment is an urgent requirement. Main body: In this review, several current treatments for HCC patients and their advantages or disadvantages were summarized. Moreover, various recent preclinical and clinical studies about the performances of "two efficient agents, sorafenib or natural killer (NK) cells", against HCC cells were investigated...
2018: Cancer Cell International
Shaoqiang Wang, Yingying Zheng, Zhiwei He, Wolong Zhou, Yuanda Cheng, Chunfang Zhang
Background: Non-small cell lung cancer (NSCLC), the most prevalent type of human lung cancer, is characterized by many molecular abnormalities. SH2B1, a member of the SH2-domain containing family, have recently been shown to act as tumor activators in multiple cancers. The objective of this study was to investigate the role SH2B1 and the underlying molecular mechanism in NSCLC. Methods: Cell functional analysis and cell line-derived xenograft model were performed to determine SH2B1 potential roles on NSCLC cell proliferation in vitro and in vivo...
2018: Cancer Cell International
Matteo Fassan, Luca Vianello, Diana Sacchi, Giuseppe N Fanelli, Giada Munari, Marco Scarpa, Rocco Cappellesso, Fotios Loupakis, Cristiano Lanza, Roberta Salmaso, Claudia Mescoli, Nicola Valeri, Marco Agostini, Edoardo D'Angelo, Sara Lonardi, Salvatore Pucciarelli, Nicola Veronese, Claudio Luchini, Massimo Rugge
Background: No data is available on the molecular background of the extra-nodal extension (ENE) of lymph node metastasis (LN) in colorectal cancer (CRC). Methods: A series of 22 ENE-positive CRCs was considered and three samples per case were selected (the primary CRC, an ENE-negative and an ENE-positive metastatic LN). Samples (n = 66) were analysed by immunohistochemistry for PD-L1, CD4, CD8, CD68 and CD80. Fifteen out of twenty-two cases were further profiled through a hotspot multigene mutational custom panel, including 164 hotspot regions of AKT1 , APC , BRAF , CTNNB1 , KIT , KRAS , NRAS , PDGFRA , PIK3CA , PTEN and TP53 genes...
2018: Cancer Cell International
Adewale Oluwaseun Fadaka, Babajide A Ojo, Olusola Bolaji Adewale, Temitope Esho, Ashley Pretorius
Background: Colorectal cancer (CRC) is one of the most common cancers diagnosed and among the commonest causes of cancer-related mortality globally. Despite the various available treatment options, millions of people still suffer from this illness and most of these treatment options have several limitations. Therefore, a less expensive, non-invasive or a treatment that requires the use of dietary products remains a focal point in this review. Main body: Aberrant microRNA expression has been revealed to have a functional role in the initiation and progression of CRC...
2018: Cancer Cell International
Marie Saghaeian Jazi, Nader Mansour Samaei, Seyed Javad Mowla, Babak Arefnezhad, Morteza Kouhsar
Background: SOX2 overlapping transcript (SOX2OT) is a long non-coding RNA, over-expressed in human tumor tissues and embryonic cells. Evidences support its function in the cell cycle; however there is no clear mechanism explaining its function in cell proliferation regulation. Here we investigated cancer cell response to SOX2OT knockdown by RNA sequencing. Methods: SOX2OT expression was inhibited by siRNA in two cancer cell lines (A549, U-87 MG), then the RNA of treated cells were used for the cDNA library synthesis and RNA sequencing...
2018: Cancer Cell International
Shao-Hsuan Wen, Shey-Chiang Su, Bo-Huang Liou, Cheng-Hao Lin, Kuan-Rong Lee
Background: Multidrug resistance (MDR) is a major obstacle in breast cancer treatment. The predominant mechanism underlying MDR is an increase in the activity of adenosine triphosphate (ATP)-dependent drug efflux transporters. Sulbactam, a β-lactamase inhibitor, is generally combined with β-lactam antibiotics for treating bacterial infections. However, sulbactam alone can be used to treat Acinetobacter baumannii infections because it inhibits the expression of ATP-binding cassette (ABC) transporter proteins...
2018: Cancer Cell International
Fan Feng, Xiaolan Zhu, Chunyan Wang, Liang Chen, Weiping Cao, Yueqin Liu, Qi Chen, Wenlin Xu
Background: MicroRNAs are small RNAs (~ 22 nt) that modulate the expression of thousands of genes in tumors and play important roles in the formation of multidrug resistance. In this study, we firstly investigated that miR - 4532 involved in the multidrug resistance formation of breast cancer by targeting hypermethylated in cancer 1 ( HIC - 1 ), a tumor-suppressor gene. Methods: To identify and characterize the possible miRNAs in regulating multidrug resistance, we employed the transcriptome sequencing approach to profile the changes in the expression of miRNAs and their target mRNAs were obtained by bioinformatics prediction...
2018: Cancer Cell International
Lujun Chen, Jun Feng, Bin Xu, You Zhou, Xiao Zheng, Changping Wu, Jingting Jiang
Background: Recent studies have suggested that B7-H6, a new member of the B7 family of ligands, not only is a crucial regulator of NK cell-mediated immune responses but also has important clinical implications due to its abnormal expression in many human cancers. We have previously reported that higher B7-H6 expression levels in ovarian cancer tissues are positively correlated with tumor metastasis and cancer progression. To date, the expression of B7-H6 in human hepatocellular carcinoma (HCC) and the clinical significance of B7-H6 expression still remain elusive...
2018: Cancer Cell International
Dan Dong, Zhongyi Mu, Chenghai Zhao, Mingli Sun
Long non-coding RNAs (lncRNA) are classified as a kind of RNA, which are longer than 200 nucleotides in length and cannot be translated into proteins. Multiple studies have demonstrated that lncRNAs are involved in various cellular processes, including proliferation, differentiation, cell death, and metastasis. In addition, aberrant expression of lncRNAs has been discovered in human tumors, where they function as either oncogenes or tumor suppressor genes. Among numerous lncRNAs, we focus on ZNFX1 antisense RNA 1 ( ZFAS1 ), a well-known lncRNA that is aberrant overexpression in various tumors, including melanoma, esophageal squamous cell carcinoma, non-small cell lung cancer, gastric cancer, colon cancer, and Hepatocellular carcinoma, in which it functions as oncogene...
2018: Cancer Cell International
Yong-Xia Wang, Hui-Fang Zhu, Zhe-Ying Zhang, Feng Ren, Yu-Han Hu
Background: Growing evidence suggests that MiRNAs play essential roles in the initiation and progression of colorectal cancer (CRC). The aberrant expression of miR-384 has been reported in some cancers. However, the role and mechanism of miR-384 in CRC proliferation remains unknown. Methods: The expression of miR-384 was detected in CRC and their paired normal tissues by real-time PCR. In vivo and in vitro assays were conducted to confirm the role of miR-384 in the proliferation of CRC...
2018: Cancer Cell International
Wanghua Chen, Wenling Wang, Yuxin Li, Hongmin Dong, Gang Wang, Xiaokai Li
Background: To investigate the efficacy and safety of concurrent chemoradiotherapy with capecitabine or oxaliplatin in locally advanced (T3-4/N + M0) rectal cancer. Methods: 56 patients with rectal cancer after radical operation were randomly divided into CAPE-OX-CRT group: capecitabine + oxaliplatin concurrent chemoradiotherapy (30 cases), CAPE-CRT group: capecitabine concurrent chemoradiotherapy (control, 26 cases). Results: The incidence of grade 1-2 acute toxicity in CAPE-OX-CRT group during concurrent CRT was significantly higher than that in control group, the difference was statistically significant (P < 0...
2018: Cancer Cell International
Xuejiao Yin, Sui Huang, Ruiqi Zhu, Fengjuan Fan, Chunyan Sun, Yu Hu
Background: LncRNAs can regulate miRNAs and mRNAs by sequestering and binding them. Indeed, many researchers have reported lncRNA mediated-competing endogenous RNAs (ceRNAs) could regulate the progression of solid tumors. However, the roles of ceRNA in acute myeloid leukemia (AML), especially in pediatric and adolescent AML, were not completely expounded. Materials and methods: 27 cytogenetically normal acute myeloid leukemia (CN-AML) patients under 18 years old with corresponding clinical data were selected from the cancer genome atlas (TCGA), which was a large sample sequencing database of RNA sequencing...
2018: Cancer Cell International
Yibo Dong, Yang Zheng, Chundi Wang, Xu Ding, Yifei Du, Laikui Liu, Wei Zhang, Wei Zhang, Yi Zhong, Yunong Wu, Xiaomeng Song
Background: Local or distant metastasis remains the main course of death in head and neck squamous cell carcinoma (HNSCC) patients. MicroRNAs (miRNAs) have been implicated in metastasis of HNSCC, but the mechanisms of their action are mainly undocumented. Through public head and neck cancer miRNA expression datasets, we found that miR-876-5p was a novel potential tumor suppressor targeting HNSCC metastasis. Methods: Clinical significance and mechanism of miR-876-5P was systematically analyzed in HNSCC...
2018: Cancer Cell International
Li She, Yuexiang Qin, Juncheng Wang, Chao Liu, Gangcai Zhu, Guo Li, Ming Wei, Changhan Chen, Guancheng Liu, Diekuo Zhang, Xiyu Chen, Yunyun Wang, Yuanzheng Qiu, Yongquan Tian, Xin Zhang, Yong Liu, Donghai Huang
Background: Alternatively activated macrophages in tumor microenvironment is defined as M2 tumor-associated macrophages (M2 TAMs) that promote cancer progression. However, communicative mechanisms between M2 TAMs and cancer cells in squamous cell carcinoma of head and neck (SCCHN) remain largely unknown. Methods: Quantitative real-time PCR, western blotting, enzyme-linked immunosorbent assay and flow cytometry were applied to quantify mRNA and protein expression of genes related to M2 TAMs, epithelial-mesenchymal transition (EMT) and stemness...
2018: Cancer Cell International
Shidai Mu, Lisha Ai, Fengjuan Fan, You Qin, Chunyan Sun, Yu Hu
Background: The neutrophil-to-lymphocyte ratio (NLR), a biomarker for systematic inflammation, has been recently identified as a prognostic factor for various types of both solid and hematologic malignancies. Here we conducted an updated dose-response meta-analysis to investigate whether NLR can be served as a prognostic biomarker in diffuse large B cell lymphoma (DLBCL). Methods: We systematically searched PubMed, Embase, ISI Web of Science and CNKI for relevant studies...
2018: Cancer Cell International
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