journal
MENU ▼
Read by QxMD icon Read
search

Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences

journal
https://www.readbyqxmd.com/read/29990717/bioanalytical-method-validation-of-endogenous-substances-according-to-guidelines-by-the-fda-and-other-organizations-basic-need-to-specify-concentration-ranges
#1
Dimitrios Tsikas
No abstract text is available yet for this article.
July 5, 2018: Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences
https://www.readbyqxmd.com/read/29990718/recent-development-of-chromatographic-methods-to-determine-parabens-in-breast-milk-samples-a-review
#2
REVIEW
Caroline Fernandes Grecco, Israel D Souza, Maria Eugênia Costa Queiroz
Parabens have been widely used as antimicrobial preservatives in food, drugs, and cosmetics for over 60 years. These endocrine disruptors can alter both the wildlife and the human hormone function. Determining these compounds in human milk is important because breast milk plays an important role in infant growth and in neurocognitive development. This article summarizes the current state-of-the-art of chromatographic methods to determine parabens in breast milk samples. Apart from the conventional and modern microextraction sample preparation techniques described herein, the authors discuss the chromatographic systems, primarily LC-MS/MS, and the concentration ranges at which parabens have been detected in milk samples obtained from lactating women over the past few years...
July 3, 2018: Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences
https://www.readbyqxmd.com/read/29990715/validation-of-analytical-methods-for-chlordecone-and-its-metabolites-in-the-urine-and-feces-of-ewes
#3
Maïlie Saint-Hilaire, Thomas Bertin, Chanthadary Inthavong, Gwenaëlle Lavison-Bompard, Thierry Guérin, Agnès Fournier, Cyril Feidt, Guido Rychen, Julien Parinet
Chlordecone (CLD) is a Persistent Organic Pollutant used between 1972 until 1993 in the French West Indies (FWI). Due to its persistence and extensive application, a quarter of the total local agricultural acreage is still moderate to heavily polluted. In consequence, livestock may be contaminated at various levels. This is a major public health concern, particularly for local consumers. In order to better understand the fate of CLD in livestock organisms, in vivo studies are required. There is no information available about its metabolism and elimination in ruminants, common livestock in the FWI...
July 3, 2018: Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences
https://www.readbyqxmd.com/read/29990711/isolation-and-identification-of-a-novel-algicidal-peptide-from-mackerel-muscle-hydrolysate
#4
Ja Young Cho, Joong Kyun Kim
To help remedy damage from harmful algal blooms, an attempt was made to isolate an algicidal substance previously observed to be present in mackerel muscle hydrolysate. Crude extract was obtained by cold acetone precipitation, and it dissolved best in water. Through molecular weight cut-off determination and tricine-SDS PAGE, the algicidal substance was determined to be a peptide of <1 kDa. Based on this result, purification was first performed using size exclusion chromatography and preparative reverse phase high-performance liquid chromatography...
June 30, 2018: Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences
https://www.readbyqxmd.com/read/29990716/inter-laboratory-study-of-the-skin-distribution-of-4-n-butyl-resorcinol-in-ex-vivo-pig-and-human-skin
#5
LETTER
Yang Liu, Haiyan Ni, William Wargniez, Sébastien Grégoire, Ingrid Durand, Laurène Roussel-Berlier, Joan Eilstein, Qiang Jie, Tian Ma, Teng Shen, Yingyin Wang, Jie Qiu
4-n-butyl resorcinol (4-nBR) is a highly effective tyrosinase inhibitor, and can be used in cosmetic product for depigmentation purpose. Its efficacy correlates with 4-nBR that absorbed by skin. In this study, skin distribution of 4-nBR within either human or pig skin ex vivo was studied and compared by three independent laboratories. Good agreement was observed in each compartment considering usual inter-lab variability. This study supports the use of pig skin as an alternative source of skin when the availability of human skin is a limiting factor...
June 27, 2018: Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences
https://www.readbyqxmd.com/read/29990713/rapid-analysis-of-neomycin-in-cochlear-perilymph-of-guinea-pigs-using-disposable-spe-cartridges-and-high-performance-liquid-chromatography-tandem-mass-spectrometry
#6
Mian Zu, Jinan Jiang, Hui Zhao, Shili Zhang, Yan Yan, Shiwei Qiu, Shuolong Yuan, Jiawei Han, Yue Zhang, Weiwei Guo, Shiming Yang
Irreversible hearing loss induced by aminoglycoside in human through local or systemic administration route negatively impacts quality of life. The aim of this work was to develop and validate an analytical method suitable for the detection and quantification of neomycin in cochlear perilymph of guinea pig after local application. The SupelMIP SPE column was used for the pre-treatment of matrix. Chromatographic separation was conducted by a reversed phase ODS column (100 × 2.1 mm, 3 μm) at 40 °C in gradient mode with 0...
June 26, 2018: Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences
https://www.readbyqxmd.com/read/30005419/a-sensitive-method-for-the-determination-of-the-gender-difference-of-neuroactive-metabolites-in-tryptophan-and-dopamine-pathways-in-mouse-serum-and-brain-by-uhplc-ms-ms
#7
Jiaxi Yao, Haihua Lu, Zhonghe Wang, Tingwei Wang, Fangfang Fang, Jun Wang, Jing Yu, Rong Gao
Tryptophan (TRP) and dopamine (DA) pathways are of great importance for their related pathology and physiology. In the present study, a new reliable and sensitive analytical method was developed and validated for 12 neuroactive metabolites in TRP and DA pathways in mouse serum and brain by ultra-high-performance liquid chromatography coupled to tandem mass spectrometry (UHPLC-MS/MS). The method exhibited good sensitivity as the lower limit of detections ranged from 0.10 to 0.50 ng/ml and the lower limit of quantifications ranged from 0...
June 25, 2018: Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences
https://www.readbyqxmd.com/read/29990712/application-of-a-simple-methodology-to-analyze-hydroxypropyl-%C3%AE-cyclodextrin-in-urine-using-hplc-ls-in-early-niemann-pick-disease-type-c-patient
#8
Adrián Matencio, María Agustina Alcaráz-Gómez, Francisco García-Carmona, Begoña Arias, José Manuel López-Nicolás
A new methodology, based on high resolution liquid chromatography with light scatterin detector, is applied to analyze Hydroxypropyl-beta-Cyclodextrin (HPβCD) in urine samples of a child affected by Niemann-Pick Type C disease. The treatment not only stopped disease progression, but has also increased the life expectancy and quality of our patient. The pharmacokinetic of HPβCD in the patient was studied with a 92.8% of HPβCD recovered. At 88 h, no HPβCD was found in the urine. During the treatment, HPβCD has not shown toxicity...
June 25, 2018: Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences
https://www.readbyqxmd.com/read/29980102/determination-of-12-commonly-found-compounds-in-duid-cases-in-whole-blood-using-fully-automated-supported-liquid-extraction-and-uhplc-ms-ms
#9
L Kristoffersen, M Langødegård, K I Gaare, I Amundsen, M N Terland, D H Strand
A high-throughput UHPLC-MS/MS method for the most frequently found compounds; tetrahydrocannabinol (THC), amphetamine, methamphetamine, MDMA, clonazepam, diazepam, nordiazepam, oxazepam, alprazolam, nitrazepam, morphine, and codeine, in driving under the influence of drugs (DUID) cases in whole blood, is presented. Automated sample preparation by 96-well supported liquid extraction (SLE) plates with ethyl acetate + heptane (80 + 20, v/v) as organic solvent was carried out on a Freedom Evo 200 platform from Tecan...
June 25, 2018: Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences
https://www.readbyqxmd.com/read/29980100/a-new-method-for-measuring-thyroid-hormones-using-nano-lc-ms-ms
#10
Suvi Ruuskanen, Bin-Yan Hsu, Arttu Heinonen, Minna Vainio, Veerle M Darras, Tom Sarraude, Anne Rokka
This paper describes a novel mass spectrometry based analytical method for analyzing thyroid hormones (THs). Thyroid hormones play a critical role in the regulation of many biological processes such as growth, metabolism and development. Several analytical methods using liquid chromatography-mass spectrometry (LC-MS) and tandem mass spectrometry (LC-MS/MS) have previously been developed to measure THs, especially in humans. For biomedical and toxicological research using small animal models, and in ecophysiological research using wild species where sample volume is limiting, sensitive methods are needed...
June 25, 2018: Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences
https://www.readbyqxmd.com/read/29960250/simultaneous-determination-of-nine-anticoagulant-rodenticides-by-ultra-performance-liquid-chromatography-tandem-mass-spectrometry-with-ultrasound-assisted-low-density-solvent-dispersive-liquid-liquid-microextraction
#11
Zhi Yan, Hongge Li, Hui Li, Guoyin Lai, Junhao Chu, Hao Guo, Qingbiao Zhao
A sensitive determination method is developed for nine anticoagulant rodenticides (ARs) in urine samples by ultra-performance liquid chromatography-tandem mass spectrometry (UPLC-MS/MS) with ultrasound-assisted low-density solvent dispersive liquid-liquid microextraction (UA-LDS-DLLME) pretreatment. The target analytes are brodifacoum, bromadiolone, warfarin, coumachlor, coumatetralyl, difenacoum, pindone, diphacinone and chlorophacinone. The parameters that influence the extraction recovery in the UA-LDS-DLLME were systematically investigated and optimized...
June 25, 2018: Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences
https://www.readbyqxmd.com/read/29960251/an-effective-and-high-throughput-analytical-methodology-for-pesticide-screening-in-human-urine-by-disposable-pipette-extraction-and-gas-chromatography-mass-spectrometry
#12
Anderson Luiz Oenning, Josias Merib, Eduardo Carasek
In this paper, the use of disposable pipette extraction (DPX) for the determination of pesticides in human urine in possible cases of poisoning is proposed for the first time. The pesticides studied were oxamyl, propoxur, carbofuran, 3‑hydroxycarbofuran, carbaryl, methiocarb, terbufos, parathion methyl, malathion, chlorpyrifos and endosulfan. The pipette tip used for the extraction of these compounds was commercially acquired. It has a capacity of 5 mL and contains 20 mg of sorbent material (styrene-divinylbenzene)...
June 23, 2018: Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences
https://www.readbyqxmd.com/read/29980101/forced-degradation-of-l-bornesitol-a-bioactive-marker-of-hancornia-speciosa-development-and-validation-of-stability-indicating-uhplc-ms-method-and-effect-of-degraded-products-on-ace-inhibition
#13
José Hugo de Sousa Gomes, Grazielle Caroline da Silva, Steyner F Côrtes, Rodrigo Maia de Pádua, Fernão Castro Braga
The antihypertensive activity of the medicinal plant Hancornia speciosa has been previously demonstrated by us, being the activity ascribed to polyphenols and cyclitols like l-(+)-bornesitol. We herein evaluated the stability of the bioactive marker bornesitol submitted to forced degradation conditions. Bornesitol employed in the study was isolated from H. speciosa leaves. An UHPLC-ESI-MS/MS method was developed to investigate bornesitol stability based on MRM (Multiple Reaction Monitoring) acquisition mode and negative ionization mode, employing both specific (m/z 193 → 161 Da) and confirmatory (m/z 193 → 175 Da) transitions...
June 22, 2018: Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences
https://www.readbyqxmd.com/read/29936370/preparation-of-a-new-cellulose-magnetic-molecularly-imprinted-polymer-micro-spheres-to-extract-and-analyze-the-indole-3-acetic-acid-in-plant-tissues
#14
Zeyu Li, Shuting Lu, Jiaqi Jin, Ting Wang
The plant hormone auxin plays a fundamental role in the growth and development of plants. However, because of its low concentration and many other interfering substances in plant tissues, the determination of auxins is still a challenging problem. To solve this problem, a kind of novel cellulose magnetic molecularly imprinted polymer micro-spheres (CMMIPs) was prepared by entrapment technique in this study. The Fe3 O4 paramagnetic particles acted as the core and were modified by cellulose, silanized β-Cyclodextrin (β-CD) and 4-Vinylpyridine (4-VP), were adopted for the specific selective recognition cavities...
June 21, 2018: Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences
https://www.readbyqxmd.com/read/29945108/ultrasound-assisted-emulsification-microextraction-for-rapid-determination-of-unmetabolized-synthetic-polycyclic-and-nitro-aromatic-musks-in-human-urine
#15
Ting-An Chen, Wu-Hsun Chung, Erica M C Ding, Wang-Hsien Ding
An effective method to rapidly determine the presence of seven unmetabolized synthetic musks in human urine samples is developed. The target musks are five synthetic polycyclic musks (i.e., celestolide (ADBI), phantolide (AHMI), traseolide (ATII), galaxolide (HHCB), tonalide (AHTN)), and two nitro-aromatic musks (i.e., musk xylene (MX) and musk ketone (MK)). The method involved an ultrasound-assisted emulsification microextraction (USAEME) coupled with gas chromatography-mass spectrometry (GC-MS). The factors that affect USAEME efficiency were optimized in detail, and the optimized procedure involved the rapid injection of 50 μL of carbon tetrachloride into 1...
June 20, 2018: Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences
https://www.readbyqxmd.com/read/29945106/affinity-adsorption-of-bovine-hyaluronidase-with-ligands-targeting-to-active-site
#16
Yu Xin, Mengyao Hao, Guangming Fan, Yao Zhang, Mengling Zheng, Liang Zhang
Four affinity ligands were designed from 6-chloromethyluracil and 2-aminobenzimidazole and simulated for the interaction with bovine hyaluronidase-1. Regarding sequence alignment, bovine hyaluronidase-1 precursor showed circa 83.6% similarity with human hyaluronidase-1. Regarding structural modeling and molecular docking, bovine hyaluronidase-1 interacted with ligands in the active site. Using epichlorohydrin, 1,3-propanediamine and cyanuric chloride as spacers, 6-chloromethyluracil and 2-aminobenzimidazole were composed to Sepharose beads...
June 20, 2018: Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences
https://www.readbyqxmd.com/read/29935479/rapid-quantitative-analysis-of-methylphenidate-and-ritalinic-acid-in-oral-fluid-by-liquid-chromatography-triple-quadrupole-mass-spectrometry-lc-qqq-ms
#17
Carmen T Mulet, Luis E Arroyo-Mora, Lorena A Leon, Elizabeth Gnagy, Anthony P DeCaprio
Methylphenidate (MPH), which is metabolized into ritalinic acid (RA), is an amphetamine derivative largely used in the treatment of attention-deficit hyperactivity disorder, a neurological condition commonly diagnosed in early childhood. Ensuring that patients comply with clinical treatment is crucial and compliance is generally monitored in blood or urine specimens which, especially in the case of children, can be challenging to obtain on a repetitive basis. Here we report validation of a specific, non-invasive, and rapid dilute-and-shoot analytical method for the detection and quantitation of MPH and RA in oral fluid (OF)...
June 20, 2018: Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences
https://www.readbyqxmd.com/read/29990714/dry-blood-spot-sample-collection-for-post-exposure-monitoring-of-chemical-warfare-agents-in-vivo-determination-of-phosphonic-acids-using-lc-ms-ms
#18
Lilach Yishai Aviram, Miriam Magen, Shira Chapman, Adi Neufeld Cohen, Shlomi Lazar, Shai Dagan
Phosphonic acids are the direct and immediate metabolites of organophosphorus chemical warfare agents (OP-CWAs). Accordingly, their detection serves for evaluating exposure to OP-CWAs in a terror or war scenario. After exposure, phosphonic acids are present in the blood; however, blood drawing must be carried out by medical personnel, hence the number of samples that can be drawn in a mass-casualty event is limited. Herein, we describe a new approach developed for the determination of phosphonic acids in blood using Dry Blood Spots (DBSs) on a filter paper...
June 19, 2018: Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences
https://www.readbyqxmd.com/read/29980099/development-of-a-selective-and-sensitive-high-performance-liquid-chromatography-tandem-mass-spectrometry-assay-to-support-pharmacokinetic-studies-of-ly-487-379-in-rat-and-marmoset
#19
Fleur Gaudette, Adjia Hamadjida, Dominique Bédard, Stephen G Nuara, Jim C Gourdon, Véronique Michaud, Francis Beaudry, Philippe Huot
Drugs modulating the metabotropic glutamate type 2 receptor (mGluR2 ) activity may have therapeutic benefits in treating a large spectrum of neuro-psychiatric disorders, from schizophrenia to Parkinson's disease, both as a symptomatic therapy and potential disease-modifying paradigm. LY-487,379 is a highly selective mGluR2 positive allosteric modulator that is widely used to study mGluR2 function using experimental animal models. The common marmoset is a small primate that has long been used in neuroscience...
June 19, 2018: Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences
https://www.readbyqxmd.com/read/29945109/a-sensitive-liquid-chromatography-tandem-mass-spectrometry-method-for-the-quantification-of-valacyclovir-and-its-metabolite-acyclovir-in-mouse-and-human-plasma
#20
Jian Shi, Yongjun Hu, David E Smith, Hao-Jie Zhu
It is challenging to conduct a pharmacokinetic (PK) study on mice due to the limited amount of plasma one can obtain, which is also true for some clinical studies. Here, we developed and validated a simple, sensitive and robust LC-MS/MS method for measuring the prodrug valacyclovir (VACV) and its metabolite acyclovir (ACV) in mouse and human plasma. This assay utilized an acetonitrile protein precipitation method with isotope-labeled internal standards (IS) and enabled precise and accurate quantification of VACV and ACV in 10 μL plasma samples with a nine-min gradient...
June 19, 2018: Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences
journal
journal
40108
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"