Mengzhao Zhang, Yunzhong Jiang, Jichang Wang, Yangyang Yue, Wei Liu, Lu Wang, Yan Li, Weiyi Wang, Hui Cai, Zezhong Yang, Minghai Ma, Shaoying Lu, Jinhai Fan
Nei endonuclease VIII-like 3 (NEIL3), a novel tumor-related gene, is differentially expressed and involved in pathophysiological processes in multiple tumors. However, the potential biological functions and molecular mechanisms of NEIL3 in human clear cell renal cell carcinoma (ccRCC) have not been identified. In this research, we demonstrated that NEIL3, transcriptionally activated by E2F1, served as an oncogene to facilitate cell proliferation and cell cycle progression and contribute to tumorigenesis via the cyclin D1-Rb-E2F1 feedback loop in ccRCC...
November 19, 2023: DNA Repair