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Advances in Clinical and Experimental Medicine: Official Organ Wroclaw Medical University

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https://www.readbyqxmd.com/read/30525316/adropin-and-irisin-new-biomarkers-of-cardiac-status-in-patients-with-end-stage-renal-disease-a-preliminary-study
#1
Małgorzata Kałużna, Krzysztof Pawlaczyk, Krzysztof Schwermer, Krzysztof Hoppe, Magdalena Człapka-Matyasik, Aisha Yusuf Ibrahim, Nadia Sawicka-Gutaj, Andrzej Minczykowski, Katarzyna Ziemnicka, Andrzej Oko, Marek Ruchała
BACKGROUND: The new polypeptide hormones adropin and irisin have a broad impact on human metabolism and energy homeostasis. They could be potential biomarkers of cardiac injury. In end-stage renal disease (ESRD), the clinical importance of adropin and irisin is yet to be investigated. OBJECTIVES: The aim of this study was to determine the relationship between these peptides and cardiac status in ESRD patients. MATERIAL AND METHODS: Seventy-nine ESRD patients on hemodialysis (HD), peritoneal dialysis (PD) or after renal transplantation (Tx), and 40 healthy, ageand sex-matched controls (CON) were included in this study...
December 7, 2018: Advances in Clinical and Experimental Medicine: Official Organ Wroclaw Medical University
https://www.readbyqxmd.com/read/30525315/expression-of-the-pim2-gene-is-associated-with-more-aggressive-clinical-course-in-patients-with-chronic-lymphocytic-leukemia
#2
Katarzyna Kapelko-Słowik, Jarosław Dybko, Krzysztof Grzymajło, Bożena Jaźwiec, Donata Urbaniak-Kujda, Mirosław Słowik, Stanisław Potoczek, Dariusz Wołowiec
BACKGROUND: The PIM2 gene belongs to the PIM family, which encodes serine/threonine kinases involved in cell survival and apoptosis. The relation between the expression of the PIM2 gene and the course of chronic lymphocytic leukemia (CLL) has not been fully determined. OBJECTIVES: The aim of the study was to evaluate the role of the PIM2 gene as a marker of CLL malignancy and its importance as a predictive and prognostic factor. MATERIAL AND METHODS: Sixty-seven patients, 35 females and 32 males, aged 49-90 years, with de novo CLL, and 14 healthy individuals were enrolled in the study...
December 7, 2018: Advances in Clinical and Experimental Medicine: Official Organ Wroclaw Medical University
https://www.readbyqxmd.com/read/30516883/a-quantitative-method-for-measuring-the-transfection-efficiency-of-cd19-directed-chimeric-antigen-receptor-in-target-cells
#3
Na Fang, Niannian Zhong, Tingxuan Gu, Yahui Wang, Xiangqian Guo, Shaoping Ji
BACKGROUND: Adoptive cell therapy (ACT) based on chimeric antigen receptors (CARs) expressed on the surface of T cells shows a remarkable clinical outcome, particularly for B-cell malignancies. However, toxicity and side effects of CD19-redirected CAR T cells have been observed concurrently in most cases due to cytokine release and tumor cell lysis. Therefore, strictly controlling the amount of valid T cells re-transfused to patients seems to be an important step in reducing toxicity and side effects of CAR T cells...
December 5, 2018: Advances in Clinical and Experimental Medicine: Official Organ Wroclaw Medical University
https://www.readbyqxmd.com/read/30516882/dna-methylation-analysis-of-selected-genes-for-the-detection-of-early-stage-lung-cancer-using-circulating-cell-free-dna
#4
Zhiping Yang, Weibo Qi, Li Sun, Hui Zhou, Biliu Zhou, Yi Hu
BACKGROUND: Lung cancer is still the deadliest cancer in the world, but early diagnosis cannot be achieved because of the limitations of diagnostic methods. DNA methylation has been proven to be a potentially powerful tool for cancer detection and diagnosis over the past decade. OBJECTIVES: We explored whether free DNA methylation in plasma can be a reliable biomarker for noninvasive lung cancer detection. MATERIAL AND METHODS: We detected the methylation of 8 genes in plasma-free DNA of patients with pulmonary space-occupying lesions using real-time quantitative methylation-specific polymerase chain reaction (QMSP)...
December 5, 2018: Advances in Clinical and Experimental Medicine: Official Organ Wroclaw Medical University
https://www.readbyqxmd.com/read/30516881/hair-cortisol-concentration-in-a-population-without-hypothalamic-pituitary-adrenal-axis-disorders
#5
Łukasz Cieszyński, Jarosław Jendrzejewski, Piotr Wiśniewski, Anna Owczarzak, Krzysztof Sworczak
BACKGROUND: Measuring hair cortisol seems to be a good alternative to laboratory tests used thus far in routine endocrine diagnostics, primarily because it is independent of the circadian rhythm of cortisol. Due to the average hair growth of 1 cm per month, the results are related to the average blood cortisol levels over the previous weeks, months or years (depending on the length of the hair sample). OBJECTIVES: The aim of this study is an attempt to apply hair cortisol concentration (HCC) measurements to clinical endocrine diagnostics, based on reference cortisol concentrations in the blood in a population without disorders of the hypothalamic-pituitary-adrenal axis (HPA)...
December 5, 2018: Advances in Clinical and Experimental Medicine: Official Organ Wroclaw Medical University
https://www.readbyqxmd.com/read/30507073/fibrinogen-concentrate-replacement-in-ischemic-stroke-patients-after-recombinant-tissue-plasminogen-activator-treatment
#6
Laura Vandelli, Marco Marietta, Tommaso Trenti, Manuela Varani, Guido Bigliardi, Francesca Rosafio, Maria Luisa Dell'acqua, Livio Picchetto, Paolo Nichelli, Andrea Zini
BACKGROUND: Post-thrombotic intracerebral hemorrhage (ICH) is experienced by 6-8% of stroke patients and is associated with multiple factors, including acquired coagulopathy induced by the thrombolytic drug. OBJECTIVES: The objective of this study was to assess the outcome of the intravenous (IV) administration of fibrinogen concentrate in a series of acute stroke patients who developed iatrogenic fibrinogen critical depletion after IV thrombolysis. MATERIAL AND METHODS: Of the 39 ischemic stroke patients treated with IV thrombolysis with a severe hypofibrinogenemia requiring infusion with IV fibrinogen concentrate, 30 patients were treated with 2 g of IV recombinant tissue plasminogen activator (rt-PA), followed by further doses until the fibrinogen level reached 200 mg/dL in hemorrhagic patients or 100 mg/dL in non-hemorrhagic patients, and 9 were treated with IV rt-PA followed by endovascular thrombectomy...
December 3, 2018: Advances in Clinical and Experimental Medicine: Official Organ Wroclaw Medical University
https://www.readbyqxmd.com/read/30499638/emergence-of-enterobacteriaceae-co-producing-ctx-m-15-arma-and-pmqr-in-poland
#7
Katarzyna Piekarska, Katarzyna Zacharczuk, Tomasz Wołkowicz, Natalia Wolaniuk, Magdalena Rzeczkowska, Rafał Gierczyński
BACKGROUND: Plasmid-mediated extended-spectrum β-lactamases (ESBLs), 16S rRNA methylases and quinolone resistance mechanisms (PMQRs) are well-known agents conferring resistance to more than 1 antimicrobial in its group. The accumulation of these agents poses, therefore, a serious risk to public health. OBJECTIVES: The objective of this study was to investigate the presence of common ß-lactamases and 16S rRNA methylases in Qnr-producing Enterobacteriaceae and their genetic relatedness...
November 30, 2018: Advances in Clinical and Experimental Medicine: Official Organ Wroclaw Medical University
https://www.readbyqxmd.com/read/30484292/the-phospholipid-fraction-obtained-from-egg-yolk-reduces-blood-pressure-increase-induced-by-acute-stress-in-spontaneously-hypertensive-rats
#8
Helena Martynowicz, Dorian Nowacki, Grzegorz Mazur, Tadeusz Trziszka, Andrzej Szuba
BACKGROUND: Despite continuous research, an improved understanding of the pathophysiology of hypertension and the development of new antihypertensive therapies, hypertension is still the most prevalent chronic cardiovascular disease (CVD) among adults in Western societies. Stress is a common factor related to cardiovascular morbidity. An increase in blood pressure is one of the most common reactions to stress. Chronic and acute stress have also been related to cardiovascular disorders...
November 28, 2018: Advances in Clinical and Experimental Medicine: Official Organ Wroclaw Medical University
https://www.readbyqxmd.com/read/30484291/the-effect-of-anakinra-to-nephrotoxicity-with-cisplatin-induced-in-rats-biochemical-gene-expression-and-histopathological-evaluation
#9
Adalet Ozcicek, Fatih Ozcicek, Ferda Keskin Cimen, Renad Mammadov, Murat Cankaya, Talat Ezmeci, Durdu Altuner
BACKGROUND: Oxidative stress and interleukin-1 beta (IL-1β) have been reported to play a role in the pathogenesis of nephrotoxicity induced by cisplatin. OBJECTIVES: The objective of this study was to investigate the effect of anakinra, which is an IL-1β receptor antagonist, on cisplatin-induced nephrotoxicity in rats, through biochemical, gene expression and histopathological analyses. MATERIAL AND METHODS: The study was designed with 4 groups...
November 28, 2018: Advances in Clinical and Experimental Medicine: Official Organ Wroclaw Medical University
https://www.readbyqxmd.com/read/30484290/preoperative-th1-th2-and-related-cytokines-prediction-value-in-postoperative-febrile-uti-after-ureteroscopy-in-patients-with-ureteral-calculi
#10
Zhen Li, Kang-Er Wang, Xie-Lai Zhou, Jin Zhou, Chun-Hua Ye
BACKGROUND: The topic of whether preoperative Th1/Th2 cells and their related factors have a predictive value for postoperative febrile urinary tract infection (UTI) in patients with ureteral calculi has not been explored. OBJECTIVES: The objective of this study was to investigate the role of preoperative Th1/Th2 cells and related cytokines in the prediction of postoperative febrile UTI after ureteroscopy in patients with ureteral calculi. MATERIAL AND METHODS: One hundred sixty patients who underwent ureteroscopic pneumatic lithotripsy in the Affiliated Hospital of Hangzhou Normal University (China) were recruited and divided into febrile UTI group (n = 78) and non-UTI group (n = 82)...
November 28, 2018: Advances in Clinical and Experimental Medicine: Official Organ Wroclaw Medical University
https://www.readbyqxmd.com/read/30468027/does-the-transplantation-of-keratinocytes-really-reduce-the-risk-of-death-survival-analysis-of-patients-hospitalized-at-the-dr-stanis%C3%A5-aw-sakiel-centre-for-burns-treatment-in-2008-2015
#11
Diana Kitala, Agnieszka Klama-Baryła, Małgorzata Kraut, Dariusz Łowicki, Wojciech Łabuś, Justyna Glik, Marcelina Misiuga, Mariusz Nowak, Grażyna Lisowska, Raphael Olszewski, Marek Kawecki
BACKGROUND: Keratinocyte transplantation is an adjuvant procedure in the extensive burn therapy method. However, it must be taken into consideration that clinical results of keratinocyte transplantation are ambiguous and progress achieved in this method is still being verified, especially due to the high cost of cultured epithelial autograft (CEA) transplants. OBJECTIVES: The aim of this study was to verify the impact of cultured keratinocyte application on patients' survival...
November 23, 2018: Advances in Clinical and Experimental Medicine: Official Organ Wroclaw Medical University
https://www.readbyqxmd.com/read/30468026/gastric-band-migration-to-gastrointestinal-lumen-and-possibilities-of-its-surgical-treatment
#12
Anna Sawicka-Pierko, Jacek Pierko, Monika Krawczyk, Jerzy R Ładny, Jacek Dadan, Hady Razak Hady
BACKGROUND: Due to numerous late complications after laparoscopic adjustable gastric banding (LAGB), leading to band removal, a significant decrease of its application has been observed. OBJECTIVES: The objective of this study was to present complications after LAGB in our own material. MATERIAL AND METHODS: The study included 152 obese patients who underwent LAGB between 2005 and 2012. The group of women consisted of 91 patients (60%) with the following preoperative parameters: average body mass index (BMI) 42 ±3...
November 23, 2018: Advances in Clinical and Experimental Medicine: Official Organ Wroclaw Medical University
https://www.readbyqxmd.com/read/30465335/calophyllum-inophyllum-in-vaginitis-treatment-stimulated-by-electroporation-with-an-in-vitro-approach
#13
Jerzy Zalewski, Justyna Mączyńska, Katarzyna Bieżuńska-Kusiak, Julita Kulbacka, Anna Choromańska, Monika Przestrzelska, Maciej Zalewski, Zbigniew Saczko, Łucja Cwynar-Zając, Agnieszka Rusak, Jolanta Saczko
BACKGROUND: Vaginitis is one of the most common problems in clinical medicine and is cited most often during visits to obstetricians and gynecologists. Most of the inflammation cases are caused by candidiasis trichomoniasis and bacterial vaginosis. Therefore, treatment of vaginal infections must use antibiotic or antifungal drugs, which often provide quick relief to the patient. The real cause of the problem - disrupting the ecosystem of the vagina - remains unchanged. Thus, new therapeutic compounds are being explored...
November 22, 2018: Advances in Clinical and Experimental Medicine: Official Organ Wroclaw Medical University
https://www.readbyqxmd.com/read/30465334/postnatal-condition-of-the-second-twin-in-respect-to-mode-of-delivery-chorionicity-and-type-of-fetal-growth
#14
Jerzy S Florjański, Wojciech Homola, Tomasz Fuchs, Agata Pawłosek, Mariusz Kasperski
BACKGROUND: The increased use of assisted reproductive techniques (ART) contributes to the increased rate of twin pregnancies, which are burdened with a higher risk of complications. Factors that affect the condition of the second twin are understudied. OBJECTIVES: The objective of this study was to assess the impact of the delivery mode, chorionicity, amnionicity, and the type of fetal growth on the postnatal condition of the second twin. MATERIAL AND METHODS: The study included data from 475 pregnant women with twin pregnancies...
November 22, 2018: Advances in Clinical and Experimental Medicine: Official Organ Wroclaw Medical University
https://www.readbyqxmd.com/read/30462382/factors-affecting-mortality-in-children-requiring-continuous-renal-replacement-therapy-in-pediatric-intensive-care-unit
#15
Monika Miklaszewska, Przemysław Korohoda, Katarzyna Zachwieja, Alina Sobczak, Krzysztof Kobylarz, Constantinos J Stefanidis, Jolanta Goździk, Dorota Drożdż
BACKGROUND: Acute kidney injury (AKI) occurs in up to 30% of pediatric intensive care unit (PICU) patients and is associated with a high mortality rate. OBJECTIVES: The objective of the study was to evaluate factors associated with the outcome and to identify the prognostic factors in children receiving continuous renal replacement therapy (CRRT). MATERIAL AND METHODS: This was a retrospective, single-center study, including 46 patients. RESULTS: Logistic regression analysis demonstrated significant effects on patient survival exerted by the percentage of fluid overload (FO%) (odds ratio (OR): 1...
November 21, 2018: Advances in Clinical and Experimental Medicine: Official Organ Wroclaw Medical University
https://www.readbyqxmd.com/read/30411550/interactions-between-platelets-and-leukocytes-in-pathogenesis-of-multiple-sclerosis
#16
REVIEW
Angela Dziedzic, Michał Bijak
Neurodegenerative diseases are an increasing problem in the modern world. Multiple sclerosis (MS) is a major human demyelinating and degenerative disease of the central nervous system (CNS). There are many reports that point to the significant role of platelet-leukocyte interaction in neurodegenerative diseases and cardiovascular disturbances. Epidemiological studies confirm the high risk of cardiovascular diseases in patients with MS. The pathophysiology mechanisms of this multi-component disease are very complex and involve various types of cells...
November 6, 2018: Advances in Clinical and Experimental Medicine: Official Organ Wroclaw Medical University
https://www.readbyqxmd.com/read/30411549/anti-neoplastic-effects-of-aprotinin-on-human-breast-cancer-cell-lines-in-vitro-study
#17
Saeed Soleyman-Jahi, Fatemeh Sadeghi, Ziba Afshari, Tahereh Barati, Sevil Ghasemi, Samad Muhammadnejad, Saeid Amanpour, Kazem Zendehdel
BACKGROUND: Aprotinin is a nonspecific serine protease inhibitor, which can inhibit plasminogen-plasmin system and matrix metalloproteinases. Aprotinin has been investigated as an antitumor agent. However, its antineoplastic effects on breast cancer (BC) have not been investigated yet. OBJECTIVES: The objective of this study was to assess the inhibitory effects of aprotinin on human BC cell lines. We assessed the effects of aprotinin on local invasion and survival of human BC cell lines MDA-MB-231, SK-BR-3 and MCF-7 in vitro...
November 5, 2018: Advances in Clinical and Experimental Medicine: Official Organ Wroclaw Medical University
https://www.readbyqxmd.com/read/30411548/adipose-tissue-mirna-level-variation-through-conjugated-linoleic-acid-supplementation-in-diet-induced-obese-rats
#18
Maryam Nazari, Alihossein Saberi, Majid Karandish, Mohammad Taha Jalali
BACKGROUND: Conjugated linoleic acid (CLA), which is an octadecadienoic acid isomer, is believed to play different positive physiological roles, such as lowering body fat. Due to some reported side effects of CLA, like lipodystrophy and impaired glucose metabolism, it is important to establish its safety by understanding detailed molecular mechanisms. One of these mechanisms may be the role of this dietary agent in modifying the function and activity of microRNAs (miRNAs). OBJECTIVES: The aim of the study was to investigate how adipocyte miR-27a and miR-143 expression may be influenced by CLA in obese rats...
October 31, 2018: Advances in Clinical and Experimental Medicine: Official Organ Wroclaw Medical University
https://www.readbyqxmd.com/read/30411547/the-application-of-capillary-electrophoresis-mass-spectrometry-and-brdicka-reaction-in-human-and-rabbit-metallothioneins-analysis
#19
Marta Kepinska, Sona Krizkova, Ewelina Guszpit, Miguel A Merlos Rodrigo, Halina Milnerowicz
BACKGROUND: Metallothioneins (MTs) constitute a family of evolutionary conserved low molecular weight proteins with small variations in their amino acid sequences. They play a role in the regulation of trace metals metabolism, in the detoxification of heavy metal ions and in mechanisms controlling growth, differentiation and proliferation of cells. OBJECTIVES: The aim of this study was to evaluate the human and rabbit MTs purity and characterization using advanced analytical approaches...
October 31, 2018: Advances in Clinical and Experimental Medicine: Official Organ Wroclaw Medical University
https://www.readbyqxmd.com/read/30411546/making-hiv-clinic-appointments-for-clients-with-positive-hiv-results-at-testing-sites-can-improve-referral-rates
#20
Bartosz Szetela, Łukasz Łapiński, Jacek Gasiorowski, Brygida Knysz
BACKGROUND: The percentage of people living with undiagnosed HIV infection remains very high in Poland and exceeds 50% - one of the highest rates in Europe. At the same time, the number of HIV tests performed by medical doctors per 1000 inhabitants is the lowest in Europe. Thus, every effort should be made to keep diagnosed patients in care. However, a number of patients are lost to care (LTC), with the percentage depending on the testing modality used (voluntary counseling and testing sites - VCTs, private laboratories, medical clinics, clubs) and communication skills of persons giving the results...
October 31, 2018: Advances in Clinical and Experimental Medicine: Official Organ Wroclaw Medical University
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