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Advances in Clinical and Experimental Medicine: Official Organ Wroclaw Medical University

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https://www.readbyqxmd.com/read/28397450/bethesda-system-in-the-evaluation-of-thyroid-nodules-review
#1
REVIEW
Marta Wesoła, Michał Jeleń
Fine needle aspiration (FNA) biopsy is an important and widely accepted method used in the diagnosis of patients with thyroid nodules.The lack of consistency in reporting FNA taken from the thyroid gland has led to divergences in the calculation of the sensitivity and specificity of the method. Discrepancies depend on what was considered to be true or false negative/positive. This resulted in confusion among doctors, who had to decide how to manage the patient with constantly changing positive or negative results of the FNA...
January 2017: Advances in Clinical and Experimental Medicine: Official Organ Wroclaw Medical University
https://www.readbyqxmd.com/read/28397449/the-neuropsychiatric-aspect-of-the-hcv-infection
#2
REVIEW
Magdalena Więdłocha, Piotr Marcinowicz, Dorota Sokalla, Bartłomiej Stańczykiewicz
HCV infection is significantly more prevalent in the population of psychiatric patients, drug addicts and people tending to undertake risky sexual behaviors than in the general population. This article presents a spectrum of psychopathological symptoms and psychological dysfunctions, an outline of current theories on the neuropathology and psychiatric aspects of HCV infection treatment. The unspecific character of the psychopathological symptoms in the HCV infection makes the process of thorough diagnostics and adequate treatment difficult, thus the specific and characteristic features have been emphasized...
January 2017: Advances in Clinical and Experimental Medicine: Official Organ Wroclaw Medical University
https://www.readbyqxmd.com/read/28397448/analytics-of-oxidative-stress-markers-in-the-early-diagnosis-of-oxygen-dna-damage
#3
REVIEW
Natalia Dąbrowska, Andrzej Wiczkowski
Under homeostatic conditions, an equilibrium state between amounts of free radicals formed and their scavenging is observed. Free radicals are destructive only when present in excess. Pathological changes within cells and tissues can result from a persistent excess of free radicals. Living organisms are increasingly exposed to oxidative stress, resulting in oxidative DNA modifications. One such modification is 8-hydroxy-2'-deoxyguanosine (8-OHdG). It is considered a biomarker of oxidative stress and oxidative DNA damage...
January 2017: Advances in Clinical and Experimental Medicine: Official Organ Wroclaw Medical University
https://www.readbyqxmd.com/read/28397447/campylobacter-concisus-as-the-etiologic-agent-of-gastrointestinal-diseases
#4
REVIEW
Katarzyna Akutko, Krzysztof Matusiewicz
A number of reports on the pathogenic influence of Campylobacter concisus on the human body and its role in many diseases of the gastrointestinal system, including gastroesophageal reflux disease, Barrett's esophagus and inflammatory bowel disease, have appeared lately. Campylobacter concisus is a Gram negative bacteria which requires an anaerobic environment or microaerophilic environment with hydrogen for growth and is therefore difficult to culture. Due to this difficulty, the rate of infections in epidemiological data are underestimated...
January 2017: Advances in Clinical and Experimental Medicine: Official Organ Wroclaw Medical University
https://www.readbyqxmd.com/read/28397446/glucocorticoid-receptor-polymorphism-in-obesity-and-glucose-homeostasis
#5
REVIEW
Agnieszka Majer-Łobodzińska, Joanna Adamiec-Mroczek
Glucocorticoid receptor (GR) activity plays a significant role in the etiology of obesity and is essential for glucose homeostasis, the development of hyperinsulinaemia and subsequent increased fat deposition. Several polymorphisms in the GR gene have been described, and at least three of them seem to be associated with altered glucocorticoid sensitivity and changes in glucose homeostasis, and other metabolic parameters. The N363S polymorphism has been associated with increased sensitivity to glucocorticoides, increased insulin response to dexamethasone and increased plasma glucose level...
January 2017: Advances in Clinical and Experimental Medicine: Official Organ Wroclaw Medical University
https://www.readbyqxmd.com/read/28397445/-from-right-to-left-the-role-of-right-heart-catheterization-in-the-diagnosis-and-management-of-left-heart-diseases
#6
REVIEW
Marta Kałużna-Oleksy, Aleksander Araszkiewicz, Jacek Migaj, Maciej Lesiak, Ewa Straburzyńska-Migaj
Pulmonary hypertension (PH), second only to left heart diseases (LHD), is a frequent problem in clinical practice. At the same time, left heart diseases represent the most common cause of pulmonary hypertension, and the occurrence of PH in patients with chronic heart failure is usually associated with worse functional class, and prognosis. Right heart catheterization (RHC) is the "gold standard" in the diagnosis and differentiation of PH. It is also essential in the process of qualifying for a heart transplantation...
January 2017: Advances in Clinical and Experimental Medicine: Official Organ Wroclaw Medical University
https://www.readbyqxmd.com/read/28397444/catheter-ablation-of-cardiac-arrhythmias-in-pregnancy-without-fluoroscopy-a-case-control-retrospective-study
#7
Edward Koźluk, Agnieszka Piątkowska, Marek Kiliszek, Piotr Lodziński, Sylwia Małkowska, Paweł Balsam, Dariusz Rodkiewicz, Radosław Piątkowski, Dorota Zyśko, Grzegorz Opolski
BACKGROUND: Cardiac arrhythmias are common in pregnant women. In most cases, they do not require treatment other than rest, electrolyte supplementation and avoidance of strong coffee and tea. Persistent arrhythmia or the ventricular rate running at a high frequency may cause hemodynamic deterioration in the fetus or in both the fetus and the mother. OBJECTIVES: The aim of this study was to assess the prevalence and characteristics of arrhythmias in pregnant women who qualified for ablation as well as the feasibility and specific features of these interventions...
January 2017: Advances in Clinical and Experimental Medicine: Official Organ Wroclaw Medical University
https://www.readbyqxmd.com/read/28397443/an-evaluation-of-dual-source-computed-tomography-used-with-the-de-weert-classification-to-detect-vulnerable-plaque-using-ivus-virtual-histology-as-a-standard-of-reference
#8
Bartosz Dołęga-Kozierowski, Piotr Klimeczek, Michał Lis, Róża Krycińska, Anna Chrapusta, Urszula Zaleska-Dorobisz, Jerzy Garcarek, Wojciech Witkiewicz
BACKGROUND: One of the main risk factors for cerebral ischemic events is atherosclerotic disease of the internal carotid artery (ICA). Nowadays, increasing attention is being paid to the relationship between the morphological features of atherosclerotic plaque and the occurrence of stroke. Several studies have demonstrated that the presence of specific vulnerable plaque types, with a large lipid core and thin fibrous cap, can be used as an independent risk predictor of cerebral ischemic events...
January 2017: Advances in Clinical and Experimental Medicine: Official Organ Wroclaw Medical University
https://www.readbyqxmd.com/read/28397442/predictive-factors-of-thrombosis-for-patients-with-essential-thrombocythaemia-a-single-center-study
#9
Iwona Prajs, Kazimierz Kuliczkowski
BACKGROUND: Thrombotembolic complications are the leading cause of mortality in essential thrombocythemia (ET), but the definition of thrombotic risk remains far from clear. OBJECTIVES: The aim of this study was to evaluate the prognostic markers for thrombosis to identify ET patients at risk. MATERIAL AND METHODS: Forty-five consecutive patients with ET were studied. This group was divided into two subgroups ET patients with (A) and without (B) history of thrombosis...
January 2017: Advances in Clinical and Experimental Medicine: Official Organ Wroclaw Medical University
https://www.readbyqxmd.com/read/28397441/the-influence-of-the-atrial-fibrillation-episode-duration-on-the-endothelial-function-in-patients-treated-with-pulmonary-veins-isolation
#10
Michał Peller, Piotr Lodziński, Krzysztof Ozierański, Agata Tymińska, Paweł Balsam, Katarzyna Kajurek, Marek Kiliszek, Edward Koźluk, Grzegorz Opolski
BACKGROUND: Atrial fibrillation (AF) is associated with endothelial dysfunctions. OBJECTIVES: The aim of the study was to assess the influence of the duration of an AF episode on the endothelial function. MATERIAL AND METHODS: The study included 65 patients with persistent AF qualified for the percutaneous pulmonary veins isolation. Patients were divided into three subgroups with increasing time of the duration of AF episode, as follow: ≤ 7 months (n = 24 patients), from 7 to 14 months (n = 18 patients) and ≥ 14 months (n = 23 patients)...
January 2017: Advances in Clinical and Experimental Medicine: Official Organ Wroclaw Medical University
https://www.readbyqxmd.com/read/28397440/diagnostic-usefulness-of-scd163-procalcitonin-and-neopterin-for-sepsis-risk-assessment-in-critically-ill-patients
#11
Agnieszka Sapa, Alina Rak, Magdalena Wybieralska, Jakub Machoń, Anna Krzywonos-Zawadzka, Kamil Zawadzki, Marek Wełna, Mieczysław Woźniak
BACKGROUND: Sepsis is one of the most common causes of hospitalization and it is characterized by a high mortality rate in spite of the great progress in diagnosis and treatment achieved in recent years. Early diagnosis of sepsis is one of the most important elements of effective treatment. The clinical symptoms are not specific and biomarkers are considered to be useful tools in sepsis diagnostics. OBJECTIVES: The aim of our study was to evaluate the diagnostic value of sCD163 as a marker of sepsis and a comparison of it with procalcitonin and neopterin in ICU patients...
January 2017: Advances in Clinical and Experimental Medicine: Official Organ Wroclaw Medical University
https://www.readbyqxmd.com/read/28397439/ganglions-of-the-hand-and-wrist-retrospective-statistical-analysis-of-520-cases
#12
Sebastian Kuliński, Olga Gutkowska, Sylwia Mizia, Jerzy Gosk
BACKGROUND: Ganglions constitute the most common tumor type of the hand and wrist region. They have a non-neoplastic character and affect patients of all ages. OBJECTIVES: The purpose of this work was to analyze the epidemiological data of a representative group of patients diagnosed with ganglions of the hand and wrist. MATERIAL AND METHODS: Five-hundred-and-twenty patients operated on for ganglions of the hand and wrist between the years 2000 and 2014 were included in the study...
January 2017: Advances in Clinical and Experimental Medicine: Official Organ Wroclaw Medical University
https://www.readbyqxmd.com/read/28397438/intraventricular-hemorrhage-in-neonates-born-from-23-to-26-weeks-of-gestation-retrospective-analysis-of-risk-factors
#13
Dawid Szpecht, Irmina Nowak, Paulina Kwiatkowska, Marta Szymankiewicz, Janusz Gadzinowski
BACKGROUND: The study aim was to determine the incidence and analyze risk factors of IVH stage 3 and 4 in infants born before 26 weeks of gestation. OBJECTIVES: A retrospective analysis of 110 preterm babies (23-26 weeks of gestation) hospitalized from 2009 to 2014 at the Department of Neonatology of Poznan University of Medical Sciences was performed. MATERIAL AND METHODS: In the study group there were 29 (26.4%) children in the 23rd-24th weeks of pregnancy and 81 (73...
January 2017: Advances in Clinical and Experimental Medicine: Official Organ Wroclaw Medical University
https://www.readbyqxmd.com/read/28397437/objectively-measured-compliance-during-early-orthodontic-treatment-do-treatment-needs-have-an-impact
#14
Michał Sarul, Beata Kawala, Anna Kozanecka, Jan Łyczek, Joanna Antoszewska-Smith
BACKGROUND: Objective assessment of daily wear time of removable appliances is possible, so the next step is to ascertain whether the severity of malocclusion influences patients' compliance. This could help resolve the controversy over the question of whether removable appliance therapy truly works. OBJECTIVES: The aim of the study was to investigate whether the patient's orthodontic treatment needs affect the cooperation between the patient and the doctor, and to find a correlation that could affect recommendations for orthodontic treatment...
January 2017: Advances in Clinical and Experimental Medicine: Official Organ Wroclaw Medical University
https://www.readbyqxmd.com/read/28397436/relationship-of-lipoprotein-lipase-gene-variants-and-fasting-triglyceride-levels-in-a-pediatric-population-the-caspian-iii-study
#15
Roya Kelishadi, Mahin Hashemipour, Behnoosh Esteki, Mohammad Hasan Tajadini, Laleh Rafiei, Mohammad Esmaeil Motlagh, Golnaz Vaseghi, Gelayol Ardalan, Shaghayegh Haghjooy Javanmard
BACKGROUND: Lipoprotein lipase (LPL) is one of the major enzymes responsible for the hydrolysis of triglyceride (TG)-rich lipoprotein. The effects of LPL polymorphisms on serum TG are inconsistent among different populations. OBJECTIVES: This study aims to assess the TG serum concentration and distributions of three LPL single nucleotide polymorphisms (SNPs), namely D9N, HINDIII and S447X, in a nationally representative sample of Iranian adolescents. MATERIAL AND METHODS: We studied the associations between SNP genotypes and TG levels in a nationally representative sample of Iranian adolescents...
January 2017: Advances in Clinical and Experimental Medicine: Official Organ Wroclaw Medical University
https://www.readbyqxmd.com/read/28397435/female-and-male-orbit-asymmetry-digital-analysis
#16
Tomasz Lepich, Józefa Dąbek, Małgorzata Witkowska, Edyta Jura-Szołtys, Grzegorz Bajor
BACKGROUND: Standard anthropometric methods applied to measurements of the skull differentials are laden with mistakes stemming from the way the measuring devices are built and from a lack of experience on the part of the researchers. To increase objectivity, digital imaging measurements via computer systems were introduced. OBJECTIVES: The aim of this research was to assess the asymmetry of the male and female orbit with the application of the new graphic methods: raster graphics and vector graphics...
January 2017: Advances in Clinical and Experimental Medicine: Official Organ Wroclaw Medical University
https://www.readbyqxmd.com/read/28397434/the-dufourmentel-modification-of-the-limberg-flap-does-it-fit-all
#17
Maciej Sebastian, Maciej Sroczyński, Jerzy Rudnicki
BACKGROUND: Pilonidal disease is a common problem, especially in young adults. Therapy for the acute disease involves abscess incision and drainage. Treatment of the chronic disease is more complicated, due to the variety of methods and relatively high recurrence rate after surgical therapy. OBJECTIVES: The aim of this study was to investigate the effects of the Dufourmentel modification of the Limberg flap in the treatment of pilonidal disease. MATERIAL AND METHODS: The study involved 37 cases of chronic pilonidal disease that were operated on by the method presented...
January 2017: Advances in Clinical and Experimental Medicine: Official Organ Wroclaw Medical University
https://www.readbyqxmd.com/read/28397433/induction-and-maintenance-infliximab-therapy-in-children-with-moderate-to-severe-ulcerative-colitis-retrospective-multicenter-study
#18
Barbara M Iwańczak, Jarosław Kierkuś, Józef Ryżko, Mariusz Szczepanik, Sabina Więcek, Grażyna Czaja-Bulsa, Magdalena Kacperska, Bartosz Korczowski, Jolanta Maślana, Franciszek Iwańczak
BACKGROUND: Pediatric ulcerative colitis (UC) is a severe disease characterised by the presence of extensive inflammatory lesions in the colon. The administration of intravenous corticosteroids is recommended in patients with acute relapse of the disease, whereas early treatment with cyclosporine, tacrolimus or infliximab is recommended if there is no improvement. OBJECTIVES: The aim of this study was to retrospectively evaluate the efficacy and safety of infliximab therapy in the treatment of moderate-to-severe and severe relapse of pediatric UC...
January 2017: Advances in Clinical and Experimental Medicine: Official Organ Wroclaw Medical University
https://www.readbyqxmd.com/read/28397432/evaluation-of-the-infliximab-therapy-of-severe-form-of-pediatric-crohn-s-disease-in-poland-retrospective-multicenter-studies
#19
Barbara M Iwańczak, Józef Ryżko, Piotr Jankowski, Małgorzata Sładek, Agata Wasilewska, Mariusz Szczepanik, Edyta Sienkiewicz, Anna Szaflarska-Popławska, Sabina Więcek, Grażyna Czaja-Bulsa, Bartosz Korczowski, Jolanta Maślana, Franciszek Iwańczak, Magdalena Kacperska
BACKGROUND: Registration of infliximab in Poland has increased chances to induce clinical remission and mucosal healing in the severe form of pediatric Crohn's disease. OBJECTIVES: The aim of this retrospective study was to assess the results and safety of infliximab therapy in the severe form of pediatric Crohn's disease. MATERIAL AND METHODS: The study included 153 children with severe form of non-fistulizing Crohn's disease treated with infliximab...
January 2017: Advances in Clinical and Experimental Medicine: Official Organ Wroclaw Medical University
https://www.readbyqxmd.com/read/28397431/the-effects-and-safety-of-intravitreal-triamcinolone-injections-in-the-treatment-of-diabetic-macular-edema
#20
Hanna M Zając-Pytrus, Radosław Kaczmarek, Dorota Strońska-Lipowicz, Maria Pomorska, Marta Misiuk-Hojło
BACKGROUND: Diabetic macular edema (DME) is responsible for three-quarters of vision-loss cases in diabetic eye disease. In most cases, early treatment by laser photocoagulation can only stabilize vision. Glucocorticoids have been used as a local pharmacological treatment in DME when the inflammation seems to have a pathological background. OBJECTIVES: The aim of the study was to establish the effectiveness and safety of intravitreal triamcinolone injections in the treatment of DME...
January 2017: Advances in Clinical and Experimental Medicine: Official Organ Wroclaw Medical University
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