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Advances in Clinical and Experimental Medicine: Official Organ Wroclaw Medical University

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https://www.readbyqxmd.com/read/29616754/venous-insufficiency-differences-in-the-content-of-trace-elements-a-preliminary-report
#1
Agnieszka Rusak, Ewa Karuga-Kuźniewska, Benita Wiatrak, Maria Szymonowicz, Mateusz Stolarski, Małgorzata Radwan-Oczko, Rafał J Wiglusz, Paweł Pohl, Zbigniew Rybak
BACKGROUND: Venous insufficiency is still a serious clinical problem. The exact cause and molecular mechanisms of this disease are still unknown. In this study, we try to identify whether there is a difference in the level of trace elements between healthy and pathological veins. Our results show that insufficient veins have different levels of some trace elements: magnesium, calcium, manganese, and silicon compared to control samples. This study could lead to a better understanding of the molecular causes of venous insufficiency and may help to develop better methods of treatment...
April 4, 2018: Advances in Clinical and Experimental Medicine: Official Organ Wroclaw Medical University
https://www.readbyqxmd.com/read/29616753/isobolographic-additivity-among-lacosamide-lamotrigine-and-phenobarbital-in-a-mouse-tonic-clonic-seizure-model
#2
Maria W Kondrat-Wróbel, Jarogniew J Łuszczki
BACKGROUND: Epilepsy is a serious neurological disease affecting about 1% of people worldwide (65 million). Seizures are controllable with antiepileptic drugs (AEDs) in about 70% of epilepsy patients, however, there remains about 30% of patients inadequately medicated with these AEDs, who need a satisfactory control of their seizure attacks. For these patients, one of the treatment options is administration of 2 or 3 AEDs in combination. OBJECTIVES: To determine the anticonvulsant effects of a combination of 3 selected AEDs (i...
March 28, 2018: Advances in Clinical and Experimental Medicine: Official Organ Wroclaw Medical University
https://www.readbyqxmd.com/read/29616752/adrenal-hemorrhage-a-single-center-experience-and-literature-review
#3
Izabela M Karwacka, Łukasz Obołończyk, Krzysztof Sworczak
BACKGROUND: Adrenal hemorrhage (AH) is a rare condition that can lead to acute adrenal insufficiency and may be fatal. The risk factors of AH include focal adrenal lesion, abdominal trauma and anticoagulation therapy. The clinical manifestation of AH varies widely; the symptoms may be related to adrenal insufficiency or may reflect multiple organ failure. However, in many cases, the course of AH is asymptomatic. OBJECTIVES: The study is a retrospective analysis of 23 cases of AH, whose aim is to discuss the etiology and the management of selected patients, as well as a literature review...
March 27, 2018: Advances in Clinical and Experimental Medicine: Official Organ Wroclaw Medical University
https://www.readbyqxmd.com/read/29616751/mir-181a-inhibits-human-trabecular-meshwork-cell-apoptosis-induced-by-h%C3%A2-o%C3%A2-through-the-suppression-of-nf-%C3%AE%C2%BAb-and-jnk-pathways
#4
Yuwen Wang, Heding Zhou, Xiaotian Liu, Yin Han, Suqi Pan, Yanyan Wang
BACKGROUND: The trabecular meshwork (TM) plays a critical role in the outflow of aqueous humor. OBJECTIVES: In this study, we aimed to investigate the effect of miR-181a on H2O2-induced apoptosis in TM cells. MATERIAL AND METHODS: Human primary explant-derived TM cells were cultured in fibroblast medium and then treated with different concentrations of H2O2 for 2 h. We used a series of methods to carry out the research, such as MTT assay, quantitative reverse transcriptase-polymerase chain reaction (qRT-PCR), apoptosis assay, and western blot methodology...
March 26, 2018: Advances in Clinical and Experimental Medicine: Official Organ Wroclaw Medical University
https://www.readbyqxmd.com/read/29616750/comparison-of-two-models-of-inflammatory-bowel-disease-in-rats
#5
Cristina Sorina Catana, Cristian Magdas, Flaviu Alexandru Tabaran, Elena Cristina Crăciun, Georgiana Deak, Virginia Ana Magdaş, Vasile Cozma, Călin Mircea Gherman, Ioana Berindan-Neagoe, Dan Lucian Dumitraşcu
BACKGROUND: There is a need for experimental animal models for inflammatory bowel diseases (IBD), but no proposed model has been unanimously accepted. OBJECTIVES: The aim of this study was to develop 2 affordable models of IBD in rats and to compare them. MATERIAL AND METHODS: We produced IBD in rats using either dextran sodium sulfate (DSS) or 2, 4, 6-trinitrobenzene sulfonic acid (TNBS). The requirements for experimental models were: a predictable clinical course, histopathology and inflammation similar to human ulcerative colitis (UC) and Crohn's disease (CD)...
March 26, 2018: Advances in Clinical and Experimental Medicine: Official Organ Wroclaw Medical University
https://www.readbyqxmd.com/read/29616749/impact-of-selected-magnetic-fields-on-the-therapeutic-effect-in-patients-with-lumbar-discopathy-a-prospective-randomized-single-blinded-and-placebo-controlled-clinical-trial
#6
Jakub Taradaj, Marcin Ozon, Robert Dymarek, Bartosz Bolach, Karolina Walewicz, Joanna Rosińczuk
BACKGROUND: Interdisciplinary physical therapy together with pharmacological treatment constitute conservative treatment strategies related to low back pain (LBP). There is still a lack of high quality studies aimed at an objective evaluation of physiotherapeutic procedures according to their effectiveness in LBP. OBJECTIVES: The aim of this study is to carry out a prospective, randomized, single-blinded, and placebocontrolled clinical trial to evaluate the effectiveness of magnetic fields in discopathy-related LBP...
March 23, 2018: Advances in Clinical and Experimental Medicine: Official Organ Wroclaw Medical University
https://www.readbyqxmd.com/read/29616748/electrocardiographic-t-wave-parameters-in-families-with-long-qt-syndrome
#7
Grażyna Markiewicz-Łoskot, Ewa Moric-Janiszewska, Bogusław Mazurek, Marianna Łoskot, Mariola Bartusek, Agnieszka Skierska, Lesław Szydłowski
BACKGROUND: T-wave parameters, especially the Tpeak-Tend interval (TpTe), reflect the total dispersion of repolarization, whose amplification may lead to the development of life-threatening ventricular arrhythmias observed in the long QT syndrome (LQTS). OBJECTIVES: The study attempted to evaluate QT, QTp (Q-Tpeak) and TpTe (Tpeak-Tend) intervals in unaffected and affected blood relatives of children with clinically confirmed LQTS as well as to determine whether the values of these repolarization parameters may be used in clinical practice...
March 21, 2018: Advances in Clinical and Experimental Medicine: Official Organ Wroclaw Medical University
https://www.readbyqxmd.com/read/29616747/awareness-and-attitudes-towards-clinical-trials-among-polish-oncological-patients-who-had-never-participated-in-a-clinical-trial
#8
Anna Staniszewska, Adriana Lubiejewska, Aleksandra Czerw, Marta Dąbrowska-Bender, Aneta Duda-Zalewska, Dominik Olejniczak, Grzegorz Juszczyk, Magdalena Bujalska-Zadrożny
BACKGROUND: Participation in a clinical trial significantly shortens waiting time associated with receiving specialist care. Furthermore, it may be the case that, through clinical trials, subjects can access medicines that are not typically available in Poland. OBJECTIVES: The aim of this study was to determine the opinions of oncological patients about clinical trials. MATERIAL AND METHODS: The research has been carried out during the years 2014-2016...
March 21, 2018: Advances in Clinical and Experimental Medicine: Official Organ Wroclaw Medical University
https://www.readbyqxmd.com/read/29616746/interleukin-21-treatment-in-a-murine-model-as-a-novel-potential-cytokine-immunotherapy-for-colon-cancer
#9
Chen Chen, Xiaoning Liu, Yi Ren
BACKGROUND: Interleukin 21 (IL-21), which belongs to the common γ-chain (γc) family, is a novel tumor suppressor that has been shown to affect T-cell proliferation, survival and function. However, the role of IL-21 in colon cancer remains unclear. OBJECTIVES: We sought to determine whether IL-21 could inhibit the progression of colon cancer in mice; we also explored the mechanisms underlying the immunological effects of IL-21 in colon cancer. MATERIAL AND METHODS: Exogenous IL-21 protein was expressed to treat tumor-bearing mice and the production of cytokine interleukin 4, interferon gamma and lambda from CD4+ T, CD8+ T, and NK cells were measured, along with the survival times of these tumor-bearing mice...
March 21, 2018: Advances in Clinical and Experimental Medicine: Official Organ Wroclaw Medical University
https://www.readbyqxmd.com/read/29558045/liver-dysfunction-in-sepsis
#10
REVIEW
Ewa A Woźnica, Małgorzata Inglot, Ryszard K Woźnica, Lidia Łysenko
Despite continuous progress in medicine, sepsis remains the main cause of deaths in the intensive care unit. Liver failure complicating sepsis/septic shock has a significant impact on mortality in this group of patients. The pathophysiology of sepsis-associated liver dysfunction is very complicated and still not well understood. According to the Surviving Sepsis Campaign (SSC) Guidelines, the diagnosis of liver dysfunction during sepsis is based on the increase in bilirubin concentration >2 mg/dL and the occurrence of coagulation disorders with INR > 1...
March 20, 2018: Advances in Clinical and Experimental Medicine: Official Organ Wroclaw Medical University
https://www.readbyqxmd.com/read/29558044/efficacy-and-safety-of-golimumab-as-add-on-therapy-to-standard-disease-modifying-antirheumatic-drugs-results-of-the-go-more-study-in-the-polish-population
#11
Sławomir Jeka, Bogdan Batko, Mariusz Korkosz, Maria Majdan, Brygida Kwiatkowska, Iwona Dankiewicz-Fares, Jerzy M Sobiecki, Włodzimierz Samborski
BACKGROUND: The GO-MORE study was an open-label, multinational, prospective study that investigated the efficacy and safety of adding golimumab to synthetic disease-modifying antirheumatic drugs (sDMARDs) in patients with active rheumatoid arthritis (RA). OBJECTIVES: The aim of this study was to assess the efficacy and safety of golimumab add-on therapy in the Polish subpopulation of the GO-MORE study. MATERIAL AND METHODS: Patients were administered 50 mg subcutaneous doses of golimumab once a month for 6 months, while continuing therapy with sDMARDs and/or glucocorticoids (GCS)...
March 20, 2018: Advances in Clinical and Experimental Medicine: Official Organ Wroclaw Medical University
https://www.readbyqxmd.com/read/29558043/tegdma-and-udma-monomers-released-from-composite-dental-material-polymerized-with-diode-and-halogen-lamps
#12
Agnieszka Wacławczyk, Lidia Postek-Stefańska, Daria Pietraszewska, Ewa Birkner, Jolanta Zalejska-Fiolka, Iwona Wysoczańska-Jankowicz
BACKGROUND: More than 35 substances released from composite fillings have been identified. Among these, basic monomers and the so-called co-monomers are most often reported. The substances released from polymer-based materials demonstrate allergenic, cytotoxic, genotoxic, mutagenic, embryotoxic, teratogenic, and estrogenic properties. OBJECTIVES: The aim of this study was to measure the amounts of triethylene glycol dimethacrylate (TEGDMA) and urethane dimethacrylate (UDMA) monomers released from composite dental fillings to citrate-phosphate buffer with the pH of 4, 6, 8 after 24 h and 6 months from the polymerization...
March 20, 2018: Advances in Clinical and Experimental Medicine: Official Organ Wroclaw Medical University
https://www.readbyqxmd.com/read/29558042/deregulated-expression-of-hdac3-in-colorectal-cancer-and-its-clinical-significance
#13
Masoumeh Nemati, Naser Ajami, Mehrdad Asghari Estiar, Saleheh Rezapour, Reyhaneh Ravanbakhsh Gavgani, Shahryar Hashemzadeh, Hossein Samadi Kafil, Ebrahim Sakhinia
BACKGROUND: To date, 4 classes of histone deacetylases (HDACs) have been identified in humans. Class I HDACs are zinc-dependent and NAD+-independent enzymes, and include 4 isoforms closely related to yeast RPD3: HDAC1, 2, 3, and 8. OBJECTIVES: The aims of the study were to quantitatively evaluate the expression of HDAC3 in colorectal cancer (CRC) and to correlate its expression levels with clinicopathological parameters. MATERIAL AND METHODS: We characterized expression patterns of HDAC3 as class I HDAC isoforms in a cohort of 48 CRC patients by quantitative (real-time) reverse transcription polymerase chain reaction (RT-PCR)...
March 20, 2018: Advances in Clinical and Experimental Medicine: Official Organ Wroclaw Medical University
https://www.readbyqxmd.com/read/29558041/in-memory-of-professor-czes%C3%A5-aw-ni%C3%A5-ankowski-head-of-the-department-of-anatomy-wroclaw-medical-university
#14
REVIEW
Ryszard R Kacała, Krzysztof Wronecki, Arkadiusz Kacała, Zygmunt Domagała, Michał Porwolik
Professor Czesław Niżankowski was an academic teacher and researcher at several universities; head of the Department of Anatomy at Wroclaw Medical University (1966-1982); and head of the Department of Biological Sciences at the Wrocław School of Physical Education (since 1972 University School of Physical Education in Wrocław), as well as the chancellor there. He contributed greatly to the development of morphological sciences, supervising many doctoral and post-doctoral works. He dedicated considerable time to the preparation of anatomical specimens of lungs, hearts and organs of the gastrointestinal tract...
March 20, 2018: Advances in Clinical and Experimental Medicine: Official Organ Wroclaw Medical University
https://www.readbyqxmd.com/read/29558040/decoy-receptor-3-alleviates-hepatic-fibrosis-through-suppressing-inflammation-activated-by-nf-%C3%AE%C2%BAb-signaling-pathway
#15
Zhenjing Jin, Siqi Liu, Qian Zhang, Xue Shao, Jingting Ma, Liulan Pan
BACKGROUND: Hepatic fibrosis is a reversible pathological process. Inflammatory responses are the prevailing reactions during hepatic fibrosis. Decoy receptor 3 (DcR3) has been reported to have an anti-inflammatory effect. OBJECTIVES: The aim of the study was to investigate the preventive effects of DcR3 on hepatic fibrosis. MATERIAL AND METHODS: Hepatic fibrosis was induced in rats by administering intraperitoneally (ip.) 1% dimethylnitrosamine (DMN)...
March 20, 2018: Advances in Clinical and Experimental Medicine: Official Organ Wroclaw Medical University
https://www.readbyqxmd.com/read/29558039/analysis-of-peripheral-nerve-and-autonomic-nervous-system-function-and-the-stage-of-microangiopathy-in-patients-with-secondary-raynaud-s-phenomenon-in-the-course-of-connective-tissue-diseases
#16
Izabela Gosk-Bierska, Maria Misterska-Skóra, Marta Wasilewska, Małgorzata Bilińska, Jerzy Gosk, Rajmund Adamiec, Magdalena Koszewicz
BACKGROUND: The pathogenesis of secondary Raynaud's phenomenon (SRP) associated with connective tissue diseases (CTD) is not entirely understood. Nervous system dysfunction and microangiopathy are considered to be causes of this pathology. OBJECTIVES: Peripheral and autonomic nervous system function, the stage of microangiopathy, and the relationships between these in patients with SRP were analyzed. MATERIAL AND METHODS: In the study, 20 patients with CTD-related SRP and 30 healthy controls were subject to capillaroscopy, standard conduction velocity tests and conduction velocity distribution (CVD) tests in ulnar and peroneal nerves, heart rate variability (HRV), and sympathetic skin response (SSR) tests...
March 20, 2018: Advances in Clinical and Experimental Medicine: Official Organ Wroclaw Medical University
https://www.readbyqxmd.com/read/29558038/are-ivs4-snps-of-olr1-gene-associated-with-coronary-artery-disease-is-there-a-linkage-between-ivs4-snps
#17
Ozlem Kurnaz-Gomleksiz, Ozlem Kucukhuseyin, Elif Ozkok, Zehra Bugra, Oguz Ozturk, Hulya Yilmaz-Aydogan
BACKGROUND: The OLR1 gene has been identified as a candidate gene for coronary artery disease (CAD). Six single-nucleotide polymorphisms (SNPs) of the OLR1 gene located within intron 4 (IVS4-27G>C, IVS4-73C>T, IVS4-14A>G), intron 5 (IVS5-70A>G, IVS5-27G>T) and 3'UTR (188C>T) comprise a linkage disequilibrium (LD) block, which is strongly associated with the elevated risk of CAD. OBJECTIVES: We aimed to investigate the effects of the OLR1 IVS4-14A>G and -73C>T SNPs on metabolic parameters in Turkish CAD patients, and the linkage between these 2 genetic variants...
March 20, 2018: Advances in Clinical and Experimental Medicine: Official Organ Wroclaw Medical University
https://www.readbyqxmd.com/read/29558037/the-correlation-between-pancreatic-dysfunction-markers-and-selected-indices-of-periodontitis
#18
Andrzej Miskiewicz, Grzegorz Szparecki, Marek Durlik, Grażyna Rydzewska, Ireneusz Ziobrowski, Renata Górska
BACKGROUND: Periodontitis is a major risk factor of systemic diseases with inflammatory etiology. Numerous studies have established the connection between periodontal condition and diabetes, but there are no reports in the literature on the relationship between periodontitis and other pancreas conditions. The activity of pancreatic enzymes is an important parameter of pancreatic damage, and is also a diagnostic marker of acute and chronic pancreatitis, and the bleeding index determines the periodontitis activity...
March 20, 2018: Advances in Clinical and Experimental Medicine: Official Organ Wroclaw Medical University
https://www.readbyqxmd.com/read/29558036/comparison-of-the-anticonvulsant-potency-of-various-diuretic-drugs-in-the-maximal-electroshock-induced-seizure-threshold-test-in-mice
#19
Katarzyna Załuska, Maria W Kondrat-Wróbel, Jarogniew J Łuszczki
BACKGROUND: The coexistence of seizures and arterial hypertension requires an adequate and efficacious treatment involving both protection from seizures and reduction of high arterial blood pressure. Accumulating evidence indicates that some diuretic drugs (with a well-established position in the treatment of arterial hypertension) also possess anticonvulsant properties in various experimental models of epilepsy. OBJECTIVES: The aim of this study was to assess the anticonvulsant potency of 6 commonly used diuretic drugs (i...
March 20, 2018: Advances in Clinical and Experimental Medicine: Official Organ Wroclaw Medical University
https://www.readbyqxmd.com/read/29558035/the-structure-of-the-vascular-system-of-the-septomarginal-trabecula-in-the-heart-of-an-adult
#20
Miłosz Zajączkowski, Adam Kosiński, Marek Grzybiak, Rafał Kamiński, Agata Kaczyńska, Stanisław Zajączkowski, Ewa Nowicka
BACKGROUND: In cardiology, the paths of the arteries penetrating the septomarginal trabecula (SMT) are especially important. They provide blood supply to the apparatus of the right atrioventricular orifice and often form anastomoses with the system of the right coronary artery. Despite this, only a few publications discuss the morphological aspect of the septomarginal trabecula, and available histological analyses seldom deal with its blood supply. OBJECTIVES: The aim of this study was to analyze the vessel structure of the septomarginal trabecula in terms of the variability of the area of the cross-section of the lumen and the muscular layer of the artery...
March 20, 2018: Advances in Clinical and Experimental Medicine: Official Organ Wroclaw Medical University
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