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Advances in Clinical and Experimental Medicine: Official Organ Wroclaw Medical University

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https://www.readbyqxmd.com/read/30106520/the-importance-of-hypoalbuminemia-in-peritoneal-dialysis-patients-impact-of-gender
#1
Dorota Sikorska, Anna Olewicz-Gawlik, Ewa Baum, Krzysztof Pawlaczyk, Andrzej Oko
BACKGROUND: High mortality in peritoneal dialysis (PD) patients is associated with the presence of nontraditional cardiovascular risk factors, such as malnutrition. However, hypoalbuminemia in patients undergoing PD may have gender-dependent consequences. OBJECTIVES: The aim of the study was to evaluate the relationship between hypoalbuminemia, overhydration (OH), inflammation, and cardiovascular risk, depending on gender. MATERIAL AND METHODS: The group studied consisted of 54 PD patients: 26 male (mean age: 59 ±19 years) and 28 female (mean age: 52 ±15 years) patients...
August 14, 2018: Advances in Clinical and Experimental Medicine: Official Organ Wroclaw Medical University
https://www.readbyqxmd.com/read/30106268/the-diagnostic-potential-of-glutathione-s-transferase-gst-polymorphisms-in-patients-with-colorectal-cancer
#2
Joanna Waś, Monika Karasiewicz, Anna Bogacz, Karolina Dziekan, Małgorzata Górska-Paukszta, Marek Kamiński, Grzegorz Stańko, Adam Kamiński, Marcin Ożarowski, Bogusław Czerny
BACKGROUND: Colorectal cancer (CRC) is one of the most common cancers in the world. Despite improvements in screening for early diagnosis, CRC is one of the leading causes of cancer deaths. OBJECTIVES: The aim of the study was to determine a potential association between the frequency of GSTM1 and GSTT1 null genotypes and the risk of CRC in the Polish population. Moreover, we analyzed the clinical parameters with the glutathione S-transferase (GST) gene polymorphisms in patients with CRC...
August 14, 2018: Advances in Clinical and Experimental Medicine: Official Organ Wroclaw Medical University
https://www.readbyqxmd.com/read/30101579/obesity-without-comorbidity-may-also-lead-to-non-thyroidal-illness-syndrome
#3
Şakir Ö Keşkek, Özlem Kurşun, Gülay Ortoğlu, Mehmet Bankir, Zeynep Tüzün, Tayyibe Saler
BACKGROUND: Obesity mediates a series of operations in the body by increasing the production of proinflammatory cytokines. Cytokines play an important role in the development of non-thyroidal illness syndrome (NTIS). OBJECTIVES: The aim of this study was to investigate the association between obesity and NTIS. MATERIAL AND METHODS: A total of 423 subjects were included. The study group was comprised of 219 obese patients without any comorbid disease and the control group was comprised of 204 healthy subjects...
August 13, 2018: Advances in Clinical and Experimental Medicine: Official Organ Wroclaw Medical University
https://www.readbyqxmd.com/read/30091536/assessment-of-the-fto-gene-polymorphisms-in-male-patients-with-metabolic-syndrome
#4
Ryszard Ślęzak, Przemysław Leszczyński, Magdalena Warzecha, Łukasz Łaczmański, Błażej Misiak
BACKGROUND: Accumulating evidence indicates the potential involvement of the FTO gene polymorphisms in the etiology of metabolic syndrome (MetS) and related disorders. OBJECTIVES: In this study, we aimed to investigate whether the FTO gene polymorphisms are associated with the risk of MetS and its simple components in a homogeneous sample of males. MATERIAL AND METHODS: Anthropometric and biochemical parameters were assessed in 192 males. A total of 100 males met the National Cholesterol Education Program Adult Treatment Panel III (NCEP-ATPIII) criteria for a diagnosis of MetS...
August 9, 2018: Advances in Clinical and Experimental Medicine: Official Organ Wroclaw Medical University
https://www.readbyqxmd.com/read/30091535/determination-of-the-concentration-of-cathepsin-b-by-spri-biosensor-in-children-with-appendicitis-and-its-correlation-with-proteasomes
#5
Ewa Matuszczak, Marta Komarowska, Marzena Tylicka, Wojciech Dębek, Ewa Gorodkiewicz, Anna Tokarzewicz, Anna Sankiewicz, Adam Hermanowicz
BACKGROUND: Cathepsin B (CatB) belongs to a family of lysosomal cysteine proteases and plays an important role in intracellular proteolysis. OBJECTIVES: The concentration of CatB and 20S proteasome was evaluated in the serum of children with appendicitis, before and after surgery, on a basis of an innovative method for determining biomolecules concentration - surface plasmon resonance imaging (SPRI) biosensor. MATERIAL AND METHODS: Forty-two children with acute appendicitis, who were treated at the Department of Pediatric Surgery (Medical University of Bialystok, Poland), were randomly included into the study (age: 5-17 years, mean age: 11...
August 9, 2018: Advances in Clinical and Experimental Medicine: Official Organ Wroclaw Medical University
https://www.readbyqxmd.com/read/30091534/the-use-of-direct-immunofluorescence-and-nested-polymerase-chain-reaction-in-diagnosing-perinatal-infections-of-chlamydia-trachomatis
#6
Magdalena Frej-Mądrzak, Dorota Teryks-Wołyniec, Piotr Jankowski, Paulina Krochmal, Jolanta Sarowska, Agnieszka Jama-Kmiecik, Irena Choroszy-Król
BACKGROUND: Chlamydia infection is the most frequently reported infectious, sexually transmitted disease (STD). Generally, Chlamydia trachomatis (C. trachomatis) infection of neonates is the result of perinatal exposure to the mother's infected cervix. OBJECTIVES: The aim of the study was to estimate the frequency of infection caused by C. trachomatis in newborn infants. In this study of C. trachomatis perinatal infection, 107 infants born at the Wroclaw Medical University Clinic of Gynecology and Obstetrics (Poland) were tested to investigate whether C...
August 9, 2018: Advances in Clinical and Experimental Medicine: Official Organ Wroclaw Medical University
https://www.readbyqxmd.com/read/30088701/correlation-analysis-for-school-age-children-s-height-and-refractive-errors
#7
Jiawei Chen, Zhenguo Chen, Sisi Lin, Jiayu Zhang, Qiang Wang, Hongliang Zhong, Daqiu Cai
BACKGROUND: During the rapid physical and mental development, school-age children, who are beginning the learning phase, have an increasingly heavy burden on their eyes. OBJECTIVES: The aim of this study was to analyze the association of refractive errors with body height in children aged 7-14 years. MATERIAL AND METHODS: A total of 1,696 children aged 7-14 years were consecutively enrolled. Children's age, sex, height, uncorrected and corrected visual acuity were collected...
August 8, 2018: Advances in Clinical and Experimental Medicine: Official Organ Wroclaw Medical University
https://www.readbyqxmd.com/read/30088700/effectiveness-comparison-of-various-atrial-fibrillation-ablation-methods-in-patients-with-common-venous-trunk
#8
Edward Koźluk, Dorota Zyśko, Agnieszka Piątkowska, Marek Kiliszek, Piotr Lodziński, Sylwia Małkowska, Paweł Balsam, Dariusz Rodkiewicz, Małgorzata Żukowska, Grzegorz Opolski
BACKGROUND: Atrial fibrillation (AF) is a common clinical problem. The left atrium anatomy makes up a factor that may significantly affect the effectiveness of the AF ablation. OBJECTIVES: The aim of the study was to evaluate a long-term effectiveness ablation in patients with common pulmonary vein trunk (CPVT) and AF. MATERIAL AND METHODS: The outcomes of 129 procedures in 95 patients with CPVT out of 1,475 procedures carried out in 1,150 patients with AF treated with ablation, were analyzed...
August 8, 2018: Advances in Clinical and Experimental Medicine: Official Organ Wroclaw Medical University
https://www.readbyqxmd.com/read/30088352/challenges-in-diagnosis-and-treatment-of-sporadic-inclusion-body-myositis
#9
REVIEW
Agata Sebastian, Maria Misterska-Skóra, Maciej Sebastian, Roksana Kręcichwost, Katarzyna Haczkiewicz
Sporadic inclusion body myositis (sIBM) is a rare yet increasingly prevalent disease and the most common cause of inflammatory myopathy in people over the age of 50. The exact cause of the disorder is unknown. In sIBM 2 processes, first autoimmune and the other degenerative, parallelly occur in the muscle cells. The inflammation aspect is characterized by the cloning of T cells that appear to be driven by specific antigens to invade muscle fibers. The degeneration aspect is characterized by the appearance of holes in the muscle cell vacuoles, deposits of abnormal proteins within the cells and in filamentous inclusions...
August 8, 2018: Advances in Clinical and Experimental Medicine: Official Organ Wroclaw Medical University
https://www.readbyqxmd.com/read/30088351/simvastatin-increases-cell-viability-and-suppresses-the-expression-of-cytokines-and-vascular-endothelial-growth-factor-in-inflamed-human-dental-pulp-stem-cells-in-vitro
#10
Dai Xue, Zhongjian Gong, Fangyong Zhu, Yanjing Qiu, Xiaodan Li
BACKGROUND: In recent years, simvastatin has been demonstrated to be capable of inducing odontogenic differentiation in human dental pulp stem cells (DPSCs), which makes it a promising source for endodontic treatment in pulpitis. However, a comprehensive understanding of how simvastatin affects the behavior of DPSCs and its potential in pulpitis is still lacking. OBJECTIVES: In this study, we investigated the effects of simvastatin on the viability of inflamed DPSCs...
August 8, 2018: Advances in Clinical and Experimental Medicine: Official Organ Wroclaw Medical University
https://www.readbyqxmd.com/read/30088350/bridging-anticoagulation-in-patients-treated-with-vitamin-k-antagonists-prior-to-trochanteric-and-hip-fracture-surgeries-the-current-practice
#11
Krzysztof Szklanny, Michał Jakubek, Katarzyna Zbierska-Rubinkiewicz, Anetta Undas
BACKGROUND: The strategies of perioperative bridging anticoagulation in orthopedic surgical patients during oral anticoagulation (OAC) therapy with vitamin K antagonists (VKA) vary from center to center. OBJECTIVES: The aim of this single-center study was to assess the risk of bleeding and thromboembolic events (TEs) in bridged patients on VKA who underwent orthopedic surgery due to trochanteric or hip fracture. MATERIAL AND METHODS: The retrospective study included 64 patients (mean age: 80 years) who received VKA for at least 3 months prior to orthopedic procedure...
August 8, 2018: Advances in Clinical and Experimental Medicine: Official Organ Wroclaw Medical University
https://www.readbyqxmd.com/read/30088349/non-classical-and-intermediate-monocytes-in-patients-following-venous-thromboembolism-links-with-inflammation
#12
Ewa Wypasek, Agnieszka Padjas, Magdalena Szymańska, Krzysztof Plens, Maciej Siedlar, Anetta Undas
BACKGROUND: Monocyte subsets are involved in atherosclerotic vascular disease and its thromboembolic complications. Moreover, the role of monocytes has been suggested in the pathogenesis of venous thromboembolism (VTE). OBJECTIVES: We hypothesized that proinflammatory non-classical and intermediate monocytes are increased in the first months following VTE. MATERIAL AND METHODS: We enrolled 70 patients aged 18-65 years (mean 41.6 ±11.6) with the first-ever provoked (n = 32; 45...
August 8, 2018: Advances in Clinical and Experimental Medicine: Official Organ Wroclaw Medical University
https://www.readbyqxmd.com/read/30085435/the-role-of-compression-therapy-in-the-treatment-of-venous-leg-ulcers
#13
REVIEW
Paulina Mościcka, Maria T Szewczyk, Justyna Cwajda-Białasik, Arkadiusz Jawień
Epidemiological data regarding venous leg ulcers, specifically low healing rates and frequent recurrences (occurring in 20-70% of the cases), seems surprising regarding recent progress in the management of this complication. The aim of this review is to present the current state of knowledge on venous leg ulcer management, especially compression therapy. Treatment of venous ulcers should be comprehensive and wellorganized, based on modern standards and up-to-date, and should involve elaborated treatment strategies...
August 7, 2018: Advances in Clinical and Experimental Medicine: Official Organ Wroclaw Medical University
https://www.readbyqxmd.com/read/30085434/current-facts-constituting-an-understanding-of-the-nature-of-adenomyosis
#14
REVIEW
Veronika Aleksandrovych, Paweł Basta, Krzysztof Gil
Adenomyosis seems to be the most widespread coexistent pathology included under the umbrella of common benign disorders of the human uterus. The incidence of adenomyosis is under discussion since different imaging criteria are used. In the majority of cases, prevalence is determined among women with uterine fibroids and endometriosis or severe gynecological symptoms. This common benign pathology is asymptomatic in 1/3 of cases. Up to 50% of women with infertility are affected by adenomyosis. It seems to be an important risk factor for spontaneous pre-term delivery and pre-term premature rupture of the membranes...
August 7, 2018: Advances in Clinical and Experimental Medicine: Official Organ Wroclaw Medical University
https://www.readbyqxmd.com/read/30085433/occurrence-of-dietary-risk-factors-in-inflammatory-bowel-disease-influence-on-the-nutritional-status-of-patients-in-clinical-remission
#15
Joanna Pieczyńska, Anna Prescha, Katarzyna Zabłocka-Słowińska, Katarzyna Neubauer, Adam Smereka, Halina Grajeta, Jadwiga Biernat, Leszek Paradowski
BACKGROUND: Among the complex factors that may favor the occurrence of inflammatory bowel disease (IBD), genetic, immunological and environmental initiators, including nutritional factors, are listed. So far, there have been no previous studies on the type and frequency of dietary risk factors for IBD in Poland and their effect on the nutritional status of patients. OBJECTIVES: The aim of the study was to assess the influence of the frequency and type of dietary risk factors for IBD on the nutritional status of patients with ulcerative colitis (UC) and Crohn's disease (CD)...
August 7, 2018: Advances in Clinical and Experimental Medicine: Official Organ Wroclaw Medical University
https://www.readbyqxmd.com/read/30085432/dietary-acid-load-and-cardiometabolic-risk-in-the-polish-adult-population
#16
Alicja M Kucharska, Dorota E Szostak-Węgierek, Anna Waśkiewicz, Walerian Piotrowski, Urszula Stepaniak, Andrzej Pająk, Krystyna Kozakiewicz, Andrzej Tykarski, Marcin Rutkowski, Wojciech J Bielecki, Wojciech Drygas
BACKGROUND: The potential influence of disorders of acid/base homeostasis on cardiovascular risk factors has been suggested. OBJECTIVES: The aim of the study was to estimate the relationship between dietary acid load and the prevalence of cardiovascular disease and the prevalence and intensity of cardiovascular risk factors (i.e., hypertension, diabetes, overweight and obesity, dyslipidemia) in the Polish adult population. MATERIAL AND METHODS: Data was derived from a cross-sectional survey of a random sample of 6,170 Polish residents aged 20+ (Multi-Center National Population Health Examination Survey, WOBASZ II study), including anthropometric and laboratory measurements, and estimates of nutrient intakes by 24-h recall...
August 7, 2018: Advances in Clinical and Experimental Medicine: Official Organ Wroclaw Medical University
https://www.readbyqxmd.com/read/30085431/the-assessment-of-the-integrated-antioxidant-system-of-the-body-and-the-phenomenon-of-spa-reaction-in-the-course-of-radon-therapy-a-pilot-study
#17
Jadwiga M Kuciel-Lewandowska, Lilla Pawlik-Sobecka, Sylwia Płaczkowska, Izabela Kokot, Małgorzata Paprocka-Borowicz
BACKGROUND: Spa reaction is an adaptive response of an organism, emerging as a result of external factors. It is a positive element of spa therapy leading to metabolic changes, which are important for the body. The effect of these changes is an increase in immune activity and regenerative reactions of the body. The mechanism of the response is not fully known. OBJECTIVES: The aim of the study was to evaluate the changes observed in the field of the integrated antioxidant system of the body in the course of radon therapy, especially in reference to spa reaction...
August 7, 2018: Advances in Clinical and Experimental Medicine: Official Organ Wroclaw Medical University
https://www.readbyqxmd.com/read/30085430/the-anatomical-relation-of-the-extracranial-internal-carotid-artery-in-the-parapharyngeal-space
#18
Hanna J Zając, Krzysztof Lachowski, Agnieszka Lis, Tomasz Kręcicki, Jerzy Garcarek, Maciej Guziński, Tomasz Zatoński
BACKGROUND: The proximity of the internal carotid artery to the pharyngeal wall poses a risk of injury during nasopharyngeal surgery. OBJECTIVES: The aim of this study was to assess the distances between the extracranial internal carotid artery (ICA) and the pharyngeal wall. MATERIAL AND METHODS: Measurements were taken on certain levels of the pharynx using computed tomography angiography (angio-CT) scans of 97 patients. One-tailed Student's t-test for independent variables and a comparison of expected values for dependent pairs of observations were applied...
August 7, 2018: Advances in Clinical and Experimental Medicine: Official Organ Wroclaw Medical University
https://www.readbyqxmd.com/read/30085429/analysis-of-adnexal-mass-managed-during-cesarean-section
#19
Cheng Yu, Jie Wang, Weiguo Lu, Xing Xie, Xiaodong Cheng, Xiao Li
BACKGROUND: Pregnancy with an adnexal mass is one of the most common complications during pregnancy and clinicians are sometimes caught in a dilemma concerning the decision to be made regarding clinical management. OBJECTIVES: The objective of this study was to outline and discuss the clinical features, management and outcomes of adnexal masses that were encountered during a cesarean section (CS) at a university affiliated hospital in China. MATERIAL AND METHODS: The medical records of the patients with an adnexal mass observed during a CS were retrospectively collected at Women's Hospital, Zhejiang University School of Medicine, Hangzhou, China, from January 1991 to December 2011...
August 7, 2018: Advances in Clinical and Experimental Medicine: Official Organ Wroclaw Medical University
https://www.readbyqxmd.com/read/30085428/the-role-of-oprm1-polymorphism-in-the-etiology-of-alcoholism
#20
Agnieszka Samochowiec, Jerzy Samochowiec, Justyna Pełka-Wysiecka, Jolanta Kucharska-Mazur, Elżbieta Grochans, Marcin Jabłoński, Przemysław Bieńkowski, Sławomir Murawiec, Iwona Małecka, Monika Mak, Łukasz Kołodziej, Janusz Heitzman, Anna Grzywacz
BACKGROUND: Numerous studies have investigated the association between the OPRM1 A118G polymorphism (rs1799971) and alcohol dependence, but the results have been inconsistent. The endogenous opioid system has been implicated in the development of alcohol dependence for its prominent role in the central rewarding mechanism. OBJECTIVES: The aim of this study was to evaluate the role of the A118G polymorphism of the OPRM1 gene in the pathogenesis of alcohol dependence syndrome (ADS)...
August 7, 2018: Advances in Clinical and Experimental Medicine: Official Organ Wroclaw Medical University
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