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Advances in Clinical and Experimental Medicine: Official Organ Wroclaw Medical University

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https://www.readbyqxmd.com/read/27629857/photodynamic-therapy-as-a-promising-method-used-in-the-treatment-of-oral-diseases
#1
REVIEW
Ewa J Prażmo, Mirosław Kwaśny, Mariusz Łapiński, Agnieszka Mielczarek
Photodynamic therapy (PDT) consists of three elements: photosensitizer, light and oxygen. The photosensitizer has the property of selective accumulation in abnormal or infected tissues without causing any damage to the healthy cells. This innovative therapeutic method has already been successfully adapted in many fields of medicine, e.g. dermatology, gynecology, urology and cancer therapy. Dentistry is also beginning to incorporate photodisinfection for treatment of the oral cavity. The antibacterial and fungicidal properties of the photosensitizer have been used to achieve better results in root canal treatment, periodontal therapy and the eradication of candidiasis in prosthodontics...
July 2016: Advances in Clinical and Experimental Medicine: Official Organ Wroclaw Medical University
https://www.readbyqxmd.com/read/27629856/brain-mri-findings-in-neurological-complications-of-cancer-treatment
#2
REVIEW
Astra Cabaj, Monika Bekiesińska-Figatowska, Agnieszka Duczkowska, Marek Duczkowski
The amount of people living with cancer is increasing; they live longer and have thus a higher risk of developing neurological complications. Magnetic resonance as a diagnostic procedure of choice in detecting the reasons of neurological/psychiatric symptoms in oncological patients is nowadays relatively easily accessible. Early diagnosis established by radiologists familiar with neurological entities that may follow cancer treatment allow clinicians to provide proper treatment, even if the diagnosis seems unbelievable...
July 2016: Advances in Clinical and Experimental Medicine: Official Organ Wroclaw Medical University
https://www.readbyqxmd.com/read/27629855/the-role-of-mast-cells-in-alzheimer-s-disease
#3
REVIEW
Yasdani B Shaik-Dasthagirisaheb, Pio Conti
Immunity and inflammation are deeply involved in Alzheimer's disease. The most important properties of pathological Alzheimer's disease are the extracellular deposits of amyloid â-protein plaque aggregates along with other unknown mutated proteins, which are implicated in immunity and inflammation. Mast cells are found in the brain of all mammalian species and in the periphery, and their biological mediators, including cytokines/chemokines, arachidonic acid products and stored enzymes, play an import role in Alzheimer's disease...
July 2016: Advances in Clinical and Experimental Medicine: Official Organ Wroclaw Medical University
https://www.readbyqxmd.com/read/27629854/plasmatic-microrna-as-potential-biomarkers-of-multiple-sclerosis-literature-review
#4
REVIEW
Magdalena J Kacperska, Jakub Walenczak, Bartłomiej Tomasik
There is ongoing research with the goal of finding precise and sensitive biomarkers of multiple sclerosis (MS). Recently, researchers have paid particular attention to small, non-encoding, single stranded endogenous microRNA molecules (miR, miRNA). At first these molecules were thought to be found only within the cell. Today it is known, however, that they can also be found in the extracellular spaces (plasma, serum, saliva, urine, tears, sweat, milk, sperm and amniotic fluid, among others). It has been established that extracellular miRNA perform a wide spectrum of functions, such as transmitting signals between cells, modulating processes involved in angiogenesis, neurogenesis, proliferation or apoptosis...
July 2016: Advances in Clinical and Experimental Medicine: Official Organ Wroclaw Medical University
https://www.readbyqxmd.com/read/27629853/retrospective-evaluation-of-the-relationship-between-the-first-dental-visit-and-the-dental-condition-of-six-and-seven-year-old-children
#5
Iwona Grzesiak-Gasek, Urszula Kaczmarek
BACKGROUND: The delayed time of a childfs first dental visit can influence a future dental condition. OBJECTIVES: To assess the dental condition of children in relation to the age at which their first dental visit took place and the frequency of subsequent visits. MATERIAL AND METHODS: The study involved 584 parents of 6.7-year-old children regarding the age and the reason for the first childfs dental visit, the frequency of subsequent visits and caries preventive counseling obtained during the visits...
July 2016: Advances in Clinical and Experimental Medicine: Official Organ Wroclaw Medical University
https://www.readbyqxmd.com/read/27629852/relation-between-periodontal-status-and-pre-cancerous-condition-oral-lichen-planus-a-pilot-study
#6
Narendra Parkash Rai, Prafful Kumar, Shabil M Mustafa, Darshan D Divakar, Abdulaziz Al Kheraif, Ravikumar Ramakrishnaiah, Sajith Vellapally, M H N Dalati, Narashimha Reddy Parine, Sukumaran Anil
BACKGROUND: Oral lichen planus (OLP) is a common chronic mucocutaneous disease mostly seen in middle aged and elderly females. Oral lichen planus can occur in different oral sites such as gingiva, labial, buccal mucosa and on the tongue. And can have an indirect effect on initiating periodontitis. OBJECTIVES: The purpose of the study was to evaluate the periodontal status of OLP patients and compare it with that of healthy controls. The presence of erosive lesions among gingival tissues makes oral hygiene procedures difficult to perform for obvious reasons...
July 2016: Advances in Clinical and Experimental Medicine: Official Organ Wroclaw Medical University
https://www.readbyqxmd.com/read/27629851/effect-of-a-3-week-low-calorie-diet-and-balneological-treatment-on-selected-coagulation-parameters-in-morbidly-obese-patients
#7
Agnieszka Firszt-Adamczyk, Barbara Ruszkowska-Ciastek, Przemysław Adamczyk, Robert Szafkowski, Mirosława Firszt, Irena Ponikowska, Kristoffer Moe, Iza Iwan-Ziętek, Barbara Góralczyk, Krzysztof Góralczyk, Danuta Rość
BACKGROUND: The most common cause of death among people with obesity are cardiovascular complications as a result of a hypercoagulability state. OBJECTIVES: The purpose of the study was to assess the potential of coagulation system activation depending on the tissue factor and to analyze of the influence of a 3-week low-calorie diet and balneological treatment on selected coagulation parameters in morbidly obese patients. MATERIAL AND METHODS: The study included 36 patients (28 females and 8 males; mean age 46) with the value of BMI > 40 kg/m2...
July 2016: Advances in Clinical and Experimental Medicine: Official Organ Wroclaw Medical University
https://www.readbyqxmd.com/read/27629850/celiac-disease-and-epilepsy-the-effect-of-gluten-free-diet-on-seizure-control
#8
Homayoon Bashiri, Darioush Afshari, Nosrat Babaei, Mohammad R Ghadami
BACKGROUND: Determining the true prevalence of celiac disease (CD) is difficult because of many atypical symptoms. Although CD primarily affects the gastrointestinal tract, patients may be asymptomatic or have extra intestinal symptoms. OBJECTIVES: In this study, we assessed the prevalence of CD in patients with epilepsy and the effect of a gluten-free diet on seizure control in these patients. MATERIAL AND METHODS: Patients with epilepsy in Imam Reza and Farabi Hospitals, Kermanshah, Iran, were studied...
July 2016: Advances in Clinical and Experimental Medicine: Official Organ Wroclaw Medical University
https://www.readbyqxmd.com/read/27629849/expression-of-hypoxia-inducible-factor-1%C3%AE-in-invasive-breast-cancer-with-metastasis-to-lymph-nodes-correlation-with-steroid-receptors-her2-and-epo-r
#9
Anna Badowska-Kozakiewicz, Maria Sobol, Janusz Patera
BACKGROUND: Expression of hypoxia-inducible factor 1α (HIF-1α) reflects the degree of cell hypoxia and its increased expression was found in most neoplasms, their metastasis as well as in some precancerous lesions. OBJECTIVES: The study aimed to investigate the expression HIF-1α in invasive breast cancer with metastasis to lymph nodes in correlation with steroid receptors (ER-estrogen receptor, PR-progesterone receptor), HER2 (human epidermal growth factor receptor 2) and EPO-R (erythropoietin receptor)...
July 2016: Advances in Clinical and Experimental Medicine: Official Organ Wroclaw Medical University
https://www.readbyqxmd.com/read/27629848/adjustment-to-life-with-lung-cancer
#10
Aleksandra I Czerw, Urszula Religioni, Andrzej Deptała
BACKGROUND: In Poland, lung cancer is the most common type of cancer in males (20% of all cases) and third most common type of cancer in females (9% of all cases), right behind breast and colorectal cancers. Recently, 28,000 new cases of lung cancer per year were reported in both genders. OBJECTIVES: The objective of the study was to asses coping strategies, pain management, acceptance of illness and adjustment to cancer in patients diagnosed with pulmonary carcinoma and the effect of socioeconomic variables on the abovementioned issues...
July 2016: Advances in Clinical and Experimental Medicine: Official Organ Wroclaw Medical University
https://www.readbyqxmd.com/read/27629847/second-line-chemotherapy-of-advanced-colorectal-cancer-predictive-and-prognostic-factors
#11
Krzysztof Forgacz, Anil K Agrawal, Tomasz Sawicki, Grzegorz W Marek
BACKGROUND: Colorectal cancer progression presents a significant clinical problem. After its dissemination, the foundation of its treatment comprises of palliative chemotherapy. OBJECTIVES: The aim of this study was to assess the predictive and prognostic value of clinical response to second line treatment (with capecitabine or with a two-drug regimen including irinotecan) and to analyze its relation to selected clinical and pathological variables with respect to time to disease progression...
July 2016: Advances in Clinical and Experimental Medicine: Official Organ Wroclaw Medical University
https://www.readbyqxmd.com/read/27629846/clinicopathological-and-prognostic-analysis-of-neuroendocrine-carcinoma-of-the-colorectum
#12
Yongchao Zhang, Jianguo Xie, Jiaxiang Wang, Donghua Yang, Zhengyu Jiang, Guangsen Han, Qiang Fu, Yonglei Zhang
BACKGROUND: Neuroendocrine carcinoma of the colorectum is a kind of malignant tumor composed of neuroendocrine cells, with a unique hormone synthesis and secretory function. In recent years, more and more attention is being paid to this kind of tumor, with its high malignant potential, poor differentiation, high invasiveness and early metastasis. OBJECTIVES: The aim of this study was to evaluate the clinicopathological characteristics and prognosis of neuroendocrine carcinoma of the colorectum...
July 2016: Advances in Clinical and Experimental Medicine: Official Organ Wroclaw Medical University
https://www.readbyqxmd.com/read/27629845/the-activity-of-jak-stat-and-nf-%C3%AE%C2%BAb-in-patients-with-rheumatoid-arthritis
#13
Jerzy Świerkot, Beata Nowak, Anna Czarny, Ewa Zaczyńska, Renata Sokolik, Marta Madej, Lucyna Korman, Agata Sebastian, Patryk Wojtala, Łukasz Lubiński, Piotr Wiland
BACKGROUND: Research is still being conducted in order to determine the mechanisms responsible for the initiation of rheumatoid arthritis (RA) as well as for its persistence and progression. OBJECTIVES: The aim of this work was to establish the expression of the signal transducer and activator of transcription (STAT) transcription factors and the nuclear factor kappa-light-chain-enhancer of activated B cells (NFκB) transcription factor in peripheral blood leukocytes and synovial fluid cells...
July 2016: Advances in Clinical and Experimental Medicine: Official Organ Wroclaw Medical University
https://www.readbyqxmd.com/read/27629844/assessment-of-sequential-and-standard-triple-therapy-in-treatment-of-helicobacter-pylori-infection-in-children-dependent-on-bacteria-sensitivity-to-antibiotics
#14
Barbara M Iwańczak, Agnieszka Borys-Iwanicka, Monika Biernat, Grażyna Gościniak
BACKGROUND: In the last decade a 10-day schema of sequential therapy of Helicobacter pylori infection based on proton pomp inhibitor (PPI), amoxicillin (AMO), clarithromycin (CLA) and metronidazole (MET) has been introduced. Many studies have emphasized greater efficacy of this therapy in comparison to the efficacy of the standard 7-day triple therapy (PPI + AMO + CLA or MET). OBJECTIVES: The aim of the study was to assess the sequential and standard triple therapy...
July 2016: Advances in Clinical and Experimental Medicine: Official Organ Wroclaw Medical University
https://www.readbyqxmd.com/read/27629843/lower-plasma-levels-of-antioxidant-vitamins-in-patients-with-metabolic-syndrome-a-case-control-study
#15
Małgorzata M Godala, Izabela Materek-Kuśmierkiewicz, Dariusz Moczulski, Maciej Rutkowski, Franciszek Szatko, Ewelina Gaszyńska, Sławomir Tokarski, Jan Kowalski
BACKGROUND: Metabolic syndrome (MS) is a coexistence of metabolic risk factors affecting the development of cardiovascular diseases. Reactive oxygen species, which are excessively produced in MS, participate in its pathogenesis. Vitamins A, C and E are an important part of the non-enzymatic antioxidative barrier in humans. OBJECTIVES: The aim of the study was to estimate plasma vitamin A, C and E levels and the intake of these vitamins from the diet in patients with MS...
July 2016: Advances in Clinical and Experimental Medicine: Official Organ Wroclaw Medical University
https://www.readbyqxmd.com/read/27629842/predictors-of-liver-disease-severity-in-children-with-chronic-hepatitis-b
#16
Maria Pokorska-Śpiewak, Barbara Kowalik-Mikołajewska, Małgorzata Aniszewska, Magdalena Pluta, Bożena Walewska-Zielecka, Magdalena Marczyńska
BACKGROUND: Evaluation of the liver histology is essential for the management of chronic hepatitis B (CHB) in children. OBJECTIVES: The aim of this study was to analyze the histopathological features in children with CHB and compare them with clinical and laboratory data. MATERIAL AND METHODS: The study comprised 30 treatment-naïve children (mean age: 12.8 ± 2.4; mean duration of infection: 11.7 ± 2.5 years; 16/30 HBeAg-positive and 14/30 HBeAg-negative), who underwent a liver biopsy due to CHB...
July 2016: Advances in Clinical and Experimental Medicine: Official Organ Wroclaw Medical University
https://www.readbyqxmd.com/read/27629841/alpha-tocopherol-may-protect-hepatocytes-against-oxidative-damage-induced-by-endurance-training-in-growing-organisms
#17
Magdalena Górnicka, Małgorzata Drywień, Joanna Frąckiewicz, Bogdan Dębski, Agata Wawrzyniak
BACKGROUND: Training-induced oxidative stress can be reduced by α-tocopherol. Adequate intake of α-tocopherol could have health benefits for previously untrained young subjects. OBJECTIVES: The aim of this study was to determine the effects of training and different doses of α-tocopherol on exercise-induced oxidative stress in rat livers. MATERIAL AND METHODS: Young male Wistar rats (n = 40) were randomly divided into eight groups (undergoing training and not undergoing training, given orally administered α-tocopherol doses of 0, 0...
July 2016: Advances in Clinical and Experimental Medicine: Official Organ Wroclaw Medical University
https://www.readbyqxmd.com/read/27629840/abnormal-distribution-of-gamma-delta-t-lymphocytes-and-their-subsets-in-type-1-diabetes
#18
Agnieszka Zubkiewicz-Kucharska, Anna Noczyńska
BACKGROUND: It was assumed that T γδ lymphocytes (T γδ) are involved in the autoimmune destruction of beta cells, presumably as regulatory cells. OBJECTIVES: The aim of this paper was to investigate T γδ cells mean percentage (%) in peripheral blood in patients with type 1 diabetes (T1DM) at the time of diagnosis and after twelve months of observation. MATERIAL AND METHODS: A total of 41 patients (21 boys, 51.2%) with new-onset T1DM were included...
July 2016: Advances in Clinical and Experimental Medicine: Official Organ Wroclaw Medical University
https://www.readbyqxmd.com/read/27629839/diabetic-patients-with-an-acute-myocardial-infarction-in-terms-of-risk-factors-and-comorbidities-management-characteristics-of-the-highest-risk-individuals
#19
Józefa Dąbek, Mariusz Bałys, Michał Majewski, Zbigniew T Gąsior
BACKGROUND: Patients with diabetes mellitus (DM) and acute myocardial infarction (AMI) are heterogeneous individuals with different clinical status compared to patients without DM. OBJECTIVES: The aim of this study was to analyze the group of diabetic patients with ST-segment elevation MI (STEMI) or non-ST-segment elevation infarction (NSTEMI) including risk factors, medical history, laboratory findings, advancement of coronary vessel atherosclerosis, and diagnostics and therapeutic modalities performed...
July 2016: Advances in Clinical and Experimental Medicine: Official Organ Wroclaw Medical University
https://www.readbyqxmd.com/read/27629838/validation-of-the-polish-version-of-the-chronic-cough-quality-of-life-questionnaire-leicester-cough-questionnaire
#20
Marta Dąbrowska, Karolina Krakowiak, Olga Radlińska, Aleksandra Rybka, Elżbieta M Grabczak, Marta Maskey-Warzęchowska, Piotr Korczyński, Surinder S Birring, Rafał Krenke
BACKGROUND: The Leicester Cough Questionnaire (LCQ) is one of the few specific quality-of-life questionnaires (QOLQ) dedicated to measuring the impact of chronic cough on patients' health/condition. OBJECTIVES: The aim of the study was to validate the Polish version of the LCQ. MATERIAL AND METHODS: The LCQ was translated forward and backward. The Polish version of the LCQ was tested on 35 patients suffering from chronic cough (23 women, median age 60 years, nonor ex-smokers, median cough duration of 23 weeks)...
July 2016: Advances in Clinical and Experimental Medicine: Official Organ Wroclaw Medical University
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