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Advances in Clinical and Experimental Medicine: Official Organ Wroclaw Medical University

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https://www.readbyqxmd.com/read/30311752/corneal-biomechanical-properties-in-patients-with-hashimoto-s-thyroiditis
#1
Ahmet Kırgız, Kübra Şerefoğlu Çabuk, Mikail Yetmis, Kürşat Atalay
BACKGROUND: Hashimoto's thyroiditis (HT) is an autoimmune endocrine disorder that results from a dysregulation of the immune system leading to an immune attack on the thyroid gland. It has potential effects on different organs and tissues. OBJECTIVES: The aim of the study was to investigate the effect of HT on corneal biomechanical properties using the ocular response analyzer (ORA). MATERIAL AND METHODS: A total of 48 patients with HT and 49 healthy subjects were enrolled in the study...
October 12, 2018: Advances in Clinical and Experimental Medicine: Official Organ Wroclaw Medical University
https://www.readbyqxmd.com/read/30311751/design-and-control-of-system-for-elbow-rehabilitation-preliminary-findings
#2
Tadeusz Mikołajczyk, Adam Kłodowski, Emilia Mikołajewska, Paweł Walkowiak, Pedro Berjano, Jorge Hugo Villafañe, Francesco Aggogeri, Alberto Borboni, Davide Fausti, Gianluigi Petrogalli
BACKGROUND: The use of an exoskeleton elbow is considered an effective treatment in several pathologies, including post-stroke complications, traumatic brain injury (TBI) and spinal cord injury (SCI), as well as in patients with neurodegenerative disorders. The effectiveness of rehabilitation is closely linked to a suitably chosen therapy. The treatment can be performed only by specialized personnel, significantly supported by the use of automated devices. OBJECTIVES: The aim of this study was to present a novel exoskeleton for elbow rehabilitation without a complicated control system...
October 12, 2018: Advances in Clinical and Experimental Medicine: Official Organ Wroclaw Medical University
https://www.readbyqxmd.com/read/30303312/effects-of-puerarin-on-spatial-learning-and-memory-function-in-mice-with-acute-alcohol-consumption-an-evaluation-based-upon-firing-rate-and-oxygen-saturation-analysis
#3
Weitao Li, Yan Zhang, Yanbai Xue, Hejuan Yu, Yameng Zhang, Ling Tao, Yamin Yang, Zhiyu Qian
BACKGROUND: Ethanol is associated with various medical comorbidities affecting the brain and central nervous system. OBJECTIVES: The use of puerarin in treating alcohol-induced memory disorders is systematically evaluated in this study based upon an analysis of the firing rate and oxygen saturation (SO2). MATERIAL AND METHODS: A multi-channel data acquisition system and near-infrared spectroscopy (NIRS) were combined to obtain the electroneurophysiological signals and SO2 in the hippocampus of mice from the Institute of Cancer Research (ICR) after ethanol injection...
October 9, 2018: Advances in Clinical and Experimental Medicine: Official Organ Wroclaw Medical University
https://www.readbyqxmd.com/read/30303311/the-impact-of-sitagliptin-inhibitor-of-dipeptidyl-peptidase-4-dpp-4-on-the-adma-ddah-no-pathway-in-ischemic-and-reperfused-rat-livers
#4
Małgorzata Trocha, Beata Nowak, Anna Merwid-Ląd, Andrzej Szuba, Piotr Dzięgiel, Małgorzata Pieśniewska, Agnieszka Gomułkiewicz, Jerzy Wiśniewski, Tomasz Piasecki, Magdalena Gziut, Adam Szeląg, Tomasz Sozański
BACKGROUND: A correlation between the level of asymmetric dimethylarginine (ADMA) - the inhibitor of the nitric oxide (NO) synthesis - and the liver function and survival after a liver transplantation has been reported. OBJECTIVES: The aim of this study was to evaluate the effect of sitagliptin -the inhibitor of dipeptidyl peptidase-4 (DPP-4) - on the NO-ADMA-dimethylarginine dimethylaminohydrolase (DDAH) pathway in rat livers subjected to ischemia/reperfusion (IR)...
October 9, 2018: Advances in Clinical and Experimental Medicine: Official Organ Wroclaw Medical University
https://www.readbyqxmd.com/read/30289210/immunopathogenesis-of-ophthalmological-paraneoplastic-syndromes-recent-findings
#5
REVIEW
Monika Kordyś, Joanna Przeździecka-Dołyk, Anna Turno-Kręcicka, Marta Misiuk-Hojło
The aim of this study was to summarize the current knowledge of paraneoplastic syndromes involving eyes. The main interest was the immunopathogenesis of the abovementioned entities. A web search was conducted using Medline, Web of Science and Scopus engines. Key words concerning ocular paraneoplastic syndromes (OPS) such as: "ocular paraneoplastic syndrome", "cancer-associated retinopathy", "cancer-associated cone dysfunction", "melanoma-associated retinopathy", "bilateral diffuse uveal melanocytic proliferation", and "paraneoplastic optic neuritis" were combined with "immunology", "immune response", "antibodies", or "autoantibodies"...
October 5, 2018: Advances in Clinical and Experimental Medicine: Official Organ Wroclaw Medical University
https://www.readbyqxmd.com/read/30277672/withholding-and-withdrawing-life-sustaining-treatment-experiences-in-limiting-futile-therapy-from-three-polish-intensive-care-departments
#6
Jacek Siewiera, Dariusz Tomaszewski, Jacek Piechocki, Andrzej Kübler
BACKGROUND: In intensive care units (ICUs), a patient's vital functions may be maintained, regardless of the patient's chances of survival. A key issue is how to precisely determine the moment in which life-support treatment should be withheld. In many countries, the decision-making process is regulated by the guidelines of scientific societies. However, heuristic errors may influence this process. OBJECTIVES: The objective of this study was to assess factors involved in decisions to implement or withhold treatment in general ICUs in Poland...
October 2, 2018: Advances in Clinical and Experimental Medicine: Official Organ Wroclaw Medical University
https://www.readbyqxmd.com/read/30277671/the-journey-of-the-heart-failure-patient-based-on-data-from-a-single-center
#7
Anna Chuda, Joanna Berner, Małgorzata Lelonek
BACKGROUND: Care for patients with heart failure (HF) in Poland requires improvement. OBJECTIVES: The aim of this study was to define the journey of a HF patient, taking into account the specialization of the hospital ward and further highly specialized outpatient care. MATERIAL AND METHODS: Using the medical system CliniNET® we analyzed 214 consecutive patients hospitalized due to HF (ICD-10: I50) in the period from September 1, 2015, to December 31, 2015, and also the data from post-discharge outpatient care in a 3-month period...
October 2, 2018: Advances in Clinical and Experimental Medicine: Official Organ Wroclaw Medical University
https://www.readbyqxmd.com/read/30277670/diseases-of-the-oral-cavity-in-light-of-the-newest-epigenetic-research-possible-implications-for-stomatology
#8
REVIEW
Jadwiga Jośko-Ochojska, Katarzyna Rygiel, Lidia Postek-Stefańska
Epigenetics is the study of inheritable changes in gene expression without changes in the underlying deoxyribonucleic acid (DNA) sequence. The main mechanisms of epigenetic regulation include DNA methylation, modifications in histones, and micro-ribonucleic acids (miRNA). Recent research evidence has shown that environmental and lifestyle factors dynamically interact with the genome, influencing epigenetic changes, from development to the later stages of life. This happens across a spectrum, from physiological to pathological conditions, such as genetic defects, developmental disorders, infectious or inflammatory processes, cancers, mental disorders, and substance abuse...
October 2, 2018: Advances in Clinical and Experimental Medicine: Official Organ Wroclaw Medical University
https://www.readbyqxmd.com/read/30277669/do-ctrc-mutations-affect-the-development-of-alcoholic-chronic-pancreatitis-and-its-course-among-poles-preliminary-study
#9
Halina Cichoż-Lach, Małgorzata Michalak-Wojnowska, Emilia Lis-Janczarek, Jacek Wojcierowski, Marcin Hydzik
BACKGROUND: Genetic mutations are one of the etiological factors that predispose people to develop chronic pancreatitis. OBJECTIVES: The aim of our study was to examine the effect of p.Trp55*, p.Arg254Trp and c.738_761del mutations in the chemotrypsin gene (CTRC) on the development of alcoholic chronic pancreatitis (ACP) in order to answer the questions whether these mutations vary between gender groups, whether they were related to the age when ACP was first diagnosed, and whether they affected the morphological changes in the pancreas and the course of ACP...
October 2, 2018: Advances in Clinical and Experimental Medicine: Official Organ Wroclaw Medical University
https://www.readbyqxmd.com/read/30277668/clinical-pathological-characteristics-of-patients-treated-for-cancers-of-the-eyelid-skin-and-periocular-areas
#10
Robert Brodowski, Paweł Pakla, Mateusz Dymek, Małgorzata Migut, Miłosz Ambicki, Wojciech Stopyra, Dorota Ozga, Bogumił Lewandowski
BACKGROUND: Malignant cancers of the eyelid skin and the periocular area comprise 5-10% of facial skin malignant cancers. Basal cell carcinomas (BCCs) dominate, comprising approx. 80-90% of cancers of this area of the face. Considerably less often, in 9-14% of cases, squamous cell carcinomas (SCCs) are observed. OBJECTIVES: The aim of this study is to provide an epidemiological-clinical assessment of patients treated over the period 2006-2015 for primary malignant cancers of the eyelid skin considering histological diagnosis and clinical staging...
October 2, 2018: Advances in Clinical and Experimental Medicine: Official Organ Wroclaw Medical University
https://www.readbyqxmd.com/read/30277667/alox12-gene-polymorphisms-and-serum-selenium-status-in-elderly-osteoporotic-patients
#11
Atiyeh Al-E-Ahmad, Hadi Parsian, Mojtaba Fathi, Soghrat Faghihzadeh, Seyed Reza Hosseini, Haji Ghorban Nooreddini, Abbas Mosapour
BACKGROUND: Osteoporosis is a systemic bone disease which leads to a reduction in bone mass. Many studies have shown that up to 80% of bone mineral density (BMD) variations are attributed to genetic factors. Arachidonate 12-lipoxygenase enzyme, encoded by the ALOX12 gene, produces lipid peroxides as reactive oxygen species (ROS), leading to oxidative stress and the development of osteoporosis. Selenium (Se) is incorporated into selenoproteins, which may reduce the risk of osteoporosis...
October 2, 2018: Advances in Clinical and Experimental Medicine: Official Organ Wroclaw Medical University
https://www.readbyqxmd.com/read/30277666/studies-on-selected-molecular-factors-in-endometrial-cancers
#12
Anna Markowska, Monika Szarszewska, Jakub Żurawski, Stefan Sajdak, Paweł Knapp, Anna Gryboś, Anita Olejek, Wiesława Bednarek, Andrzej Roszak, Marcin Jóźwik, Andrzej Marszałek, Violetta Filas, Katarzyna Wójcik-Krowiranda, Radosław Mądry, Janina Markowska
BACKGROUND: Endometrial carcinomas (EC) differ in etiology, clinical course and prognosis. OBJECTIVES: This multi-center study aimed at a closer recognition of molecular factors linked to heterogeneity of EC by evaluating estrogen and progesterone receptors, proteins dependent on MMR genes, proteins linked to poor prognosis and metastases, and mutations in BRCA1. MATERIAL AND METHODS: Using sections of paraffin-embedded preparations, in 115 patients with EC type I and 31 with EC type II, expression of ERα, ERβ1, PR, MLH1 and MSH2 proteins, as well as ARID1A, c-MET and BRCA1, was estimated by immunohistochemistry using specific antibodies...
October 1, 2018: Advances in Clinical and Experimental Medicine: Official Organ Wroclaw Medical University
https://www.readbyqxmd.com/read/30238703/thermal-imaging-and-planimetry-evaluation-of-the-results-of-chronic-wounds-treatment-with-hyperbaric-oxygen-therapy
#13
Justyna Glik, Armand Cholewka, Beata Englisz, Agata Stanek, Karolina Sieroń, Karolina Mikuś-Zagórska, Grzegorz Knefel, Mariusz Nowak, Marek Kawecki
BACKGROUND: One of the methods to treat chronic wounds is the use of hyperbaric oxygen (HBO). Objective measurement of the wound surface is an important element in the process of monitoring and predicting the progress of treatment. OBJECTIVES: The aim of the study was to evaluate the effect of hyperbaric oxygen therapy (HBOT) on ulcer wound healing in patients with chronic venous insufficiency ulcers and diabetic foot syndrome using thermal imaging and computerized planimetry...
September 21, 2018: Advances in Clinical and Experimental Medicine: Official Organ Wroclaw Medical University
https://www.readbyqxmd.com/read/30170486/a-hypothesis-for-the-mechanism-of-urine-incontinence-in-patients-after-radical-prostatectomy-due-to-urinary-bladder-hypertrophy
#14
REVIEW
Kajetan Juszczak, Adam Ostrowski, Michał Bryczkowski, Przemysław Adamczyk, Tomasz Drewa
Prostate cancer is one of the most common neoplasms in elderly males in Europe and is rapidly becoming a major health burden throughout the world. Radical prostatectomy is a first-line treatment in the case of organ-confined prostate cancer and in selected cases of locally advanced disease. Recent studies have suggested that the urinary bladder wall thickness (BWT) is an important predictor of an overactive bladder (OAB). This article focuses on a hypothesis for the mechanism of urine incontinence in patients after radical prostatectomy due to urinary bladder hypertrophy...
August 29, 2018: Advances in Clinical and Experimental Medicine: Official Organ Wroclaw Medical University
https://www.readbyqxmd.com/read/30170485/the-effect-of-silver-nanoparticles-on-the-reproductive-system-of-adult-male-rats-a-morphological-histological-and-dna-integrity-study
#15
Nasibeh Fathi, Seyed Mohammad Hoseinipanah, Zohreh Alizadeh, Mohammad Javad Assari, Abbas Moghimbeigi, Motahare Mortazavi, Morteza Haji Hosseini, Maryam Bahmanzadeh
BACKGROUND: Silver nanoparticles (AgNPs) are more often used in various products, and consequently the potential deleterious effects associated with exposure to them are of concern. Several lines of evidence have demonstrated that the toxicity of AgNPs affects different organs and leads to some side effects, including weight loss, inflammation and cell death. OBJECTIVES: The aim of this study was to evaluate the effect of different concentrations of AgNPs on sperm parameters and testicular histology...
August 29, 2018: Advances in Clinical and Experimental Medicine: Official Organ Wroclaw Medical University
https://www.readbyqxmd.com/read/30170484/the-impact-of-low-alcohol-consumption-on-the-liver-and-inflammatory-cytokines-in-diabetic-rats
#16
Hussam W Al-Humadi, Rafal Al-Saigh, Ahmed Sahib
BACKGROUND: Diabetes mellitus (DM) and alcohol consumption is still one of the important research models that simulate variable clinical conditions and metabolic diseases, such as alcoholic liver diseases. OBJECTIVES: The aim of this study was to evaluate the long-term cumulative effects of low alcohol consumption on the liver tissue, biochemical assays and some inflammatory cytokines in experimentally-induced DM rats. MATERIAL AND METHODS: Ethanol was administered in the drinking water (3% v/v) for 30 days to adult male Sprague-Dawley rats, with or without DM induced by streptozocin injection...
August 29, 2018: Advances in Clinical and Experimental Medicine: Official Organ Wroclaw Medical University
https://www.readbyqxmd.com/read/30170483/serum-asymmetric-dimethylarginine-and-nitric-oxide-levels-in-turkish-patients-with-acute-ischemic-stroke
#17
Mujgan Ercan, Semra Mungan, Işıl Güzel, Huseyin Tugrul Celik, Ceylan Bal, Sedat Abusoglu, Deniz Akbulut, Esra Firat Oguz, Fatma Meric Yilmaz
BACKGROUND: Nitric oxide synthase (NOS) is present in the brain and cerebral arteries and it enables the synthesis of nitric oxide (NO), which plays a critical role in brain perfusion. Asymmetrical dimethylarginine (ADMA) is an endogenous NOS inhibitor. OBJECTIVES: The aim of this study was to evaluate serum ADMA levels, which are an indicator of endothelial dysfunction of the renal functions in patients with acute ischemic stroke, and to determine whether there is a possible correlation between ADMA and NO levels and the l-arginine-to-ADMA ratio...
August 29, 2018: Advances in Clinical and Experimental Medicine: Official Organ Wroclaw Medical University
https://www.readbyqxmd.com/read/30170482/academic-chemistry-and-related-fields-in-wroc%C3%A5-aw-density-equalizing-mapping-studies-over-the-past-decades
#18
REVIEW
David A Groneberg
Chemistry and related areas of science have a strong background in Wrocław with 3 Nobel laureates. The aim of this study was to assess the evolution of scientific excellence and productivity after the Second World War, when Polish scientists rebuilt academic life in these important areas. The present approach used the established platform of the New Quality and Quantity Indicators in Science (NewQIS) project and density-equalizing mapping calculations. In total, 15,267 original research articles related to chemistry published by Wrocław scientists were identified in the Web of Science between 1972 and 2016...
August 29, 2018: Advances in Clinical and Experimental Medicine: Official Organ Wroclaw Medical University
https://www.readbyqxmd.com/read/30170481/mir-494-alleviates-lipopolysaccharide-lps-induced-autophagy-and-apoptosis-in-pc-12-cells-by-targeting-il-13
#19
Wei Geng, Lei Liu
BACKGROUND: MiR-494 is reported to act as a tumor-suppressive factor that inhibits the proliferation and colony formation of some cancer cells. However, there is still no report available on miR-494 functions in spinal cord injury (SCI) until now. OBJECTIVES: The objective of this study was to examine the status of miR-494 in PC-12 cells injury induced by lipopolysaccharide (LPS), as well as its mechanism. MATERIAL AND METHODS: The cell counting kit-8 (CKK-8) assay and apoptosis assay were respectively used to determine the proliferation and apoptosis of PC-12...
August 29, 2018: Advances in Clinical and Experimental Medicine: Official Organ Wroclaw Medical University
https://www.readbyqxmd.com/read/30156389/vitamin-c-may-exert-variable-effects-on-viability-and-proliferation-of-hela-cells-exhibiting-high-and-low-chromosomal-instability
#20
Aastha Sindhwani, Sasikala Muthusammy, Alka Bhatia
BACKGROUND: Chromosomal instability (CIN), defined as abnormality in chromosome structure or number, is the hallmark of malignancies. The role of vitamin C in cancer treatment is controversial and its effect on CIN is still an open field of research. In this work, we tried to study the effect of high-dose L-ascorbic acid (L-AA) on CIN-induced (CINhi = CIN high) and non-CIN-induced (CINlo = CIN low) cervical cancer cells. OBJECTIVES: The aim of this study was to explore the effect of high-dose L-AA on CIN in the cervical cancer cell line (HeLa) cells...
August 29, 2018: Advances in Clinical and Experimental Medicine: Official Organ Wroclaw Medical University
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