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Advances in Clinical and Experimental Medicine: Official Organ Wroclaw Medical University

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https://www.readbyqxmd.com/read/29442469/brain-death-associated-pathological-events-and-therapeutic-options
#1
REVIEW
Paweł Chudoba, Wojciech Krajewski, Joanna Wojciechowska, Dorota Kamińska
BACKGROUND: At present, organ transplantation is the most efficient treatment of end-stage failure of various organs, including the heart, lungs, pancreas, intestines, kidney, and liver. Despite the efforts to use organs from living donors or from donors after circulatory death, most of the organs are recovered from brain dead (BD) donors. METHODS: The Medline and Web of Science databases were searched without time limit on November 2015 using the terms "brain dead donor" and "deceased donor" in conjunction with "transplantation", "graft", "organ", "hemodynamic", "hormonal", or "management"...
December 2017: Advances in Clinical and Experimental Medicine: Official Organ Wroclaw Medical University
https://www.readbyqxmd.com/read/29442468/the-role-of-pancreatic-polypeptide-in-pancreatic-diseases
#2
REVIEW
Mariola Śliwińska-Mossoń, Grzegorz Marek, Halina Milnerowicz
The aim of this study was to review the diagnostic significance of pancreatic polypeptide (PP) in pancreatic diseases. PP may play a significant role in monitoring the development of the disease and the patient's healing process, particularly after the removal of a portion of the pancreas. Determining PP in acute pancreatitis is quite controversial. At the 1st stage of severe pancreatic damage, there is excessive PP release followed by its fall. In patients with chronic pancreatitis, a significant decrease in PP secretion was found in the presence of a food stimulant...
December 2017: Advances in Clinical and Experimental Medicine: Official Organ Wroclaw Medical University
https://www.readbyqxmd.com/read/29442467/intestinal-epithelial-barrier-the-target-for-pathogenic-escherichia-coli
#3
REVIEW
Barbara Pawłowska, Beata M Sobieszczańska
Diarrheagenic Escherichia coli strains are included in 9 pathotypes (pathovars) that present different virulence factors responsible for the patomechanism of infections they cause. As all other intestinal pathogens, E. coli exerts a significant effect on intestinal epithelium. To initiate the infection, these microorganisms have evolved countless strategies to subvert the epithelial barrier and efficiently colonize the intestinal epithelium. The barrier function of the intestinal epithelium is achieved by the presence of a tight junction protein network surrounding individual cells around their circumference that links neighboring cells and seals the intracellular space...
December 2017: Advances in Clinical and Experimental Medicine: Official Organ Wroclaw Medical University
https://www.readbyqxmd.com/read/29442466/relationship-between-resistin-and-il-23-levels-in-follicular-fluid-in-infertile-patients-with-endometriosis-undergoing-ivf-et
#4
Qun-Fang Zhang, Guo-Yong Chen, Yun Liu, Hui-Juan Huang, Yan-Feng Song
BACKGROUND: Endometriosis (EM) interferes with the reproductive process and affects the success rate of in vitro fertilization (IVF). Inflammatory cytokines are suggested to play a role in infertility in patients with EM. OBJECTIVES: In this study, we aimed to investigate the relationship between resistin and interleukin 23 (IL-23) levels in follicular fluid (FF) and serum together with the severity of endometriosis and in vitro fertilization/ embryo transfer (IVF-ET) outcome...
December 2017: Advances in Clinical and Experimental Medicine: Official Organ Wroclaw Medical University
https://www.readbyqxmd.com/read/29442465/polymorphism-of-gly39glu-c-116g-a-hmsh6-is-associated-with-sporadic-colorectal-cancer-development-in-the-polish-population-preliminary-results
#5
Piotr Zelga, Karolina Przybyłowska-Sygut, Marta Zelga, Adam Dziki, Ireneusz Majsterek
BACKGROUND: Colorectal cancer (CRC) remains a major source of cancer-related mortality, accounting for 10% of all cancer-related deaths. DNA mismatch repair mechanism (MMR) responsible for correcting errors generated during DNA replication and its deficiency is associated with both hereditary and sporadic CRC. Single-nucleotide polymorphisms (SNPs) are the most common forms of genetic variation, and it has been shown that the SNPs in MMR genes may modify CRC risk. OBJECTIVES: The aim of the study was to determine the relationship between gene polymorphism Glu39Gly (c...
December 2017: Advances in Clinical and Experimental Medicine: Official Organ Wroclaw Medical University
https://www.readbyqxmd.com/read/29442464/effects-of-vector-ultrasonic-system-debridement-and-conventional-instrumentation-on-the-levels-of-tnf-%C3%AE-in-gingival-crevicular-fluid-of-patients-with-chronic-periodontitis
#6
Osman Fatih Arpağ, Ahmet Dağ, Bozan Serhat İzol, Gülcan Cimitay, Ersin Uysal
BACKGROUND: Tumor necrosis factor alpha (TNF-α) is an inflammatory mediator whose levels are increased in the gingival crevicular fluid and blood serum in the case of chronic periodontitis. OBJECTIVES: The aim of this study was to determine the effect of vector ultrasonic system (VUS) on the levels of TNF-α in gingival crevicular fluid (GCF) and the clinical parameters in patients with chronic periodontitis. MATERIAL AND METHODS: The study protocol was conducted using split-mouth design in 30 patients with chronic periodontitis...
December 2017: Advances in Clinical and Experimental Medicine: Official Organ Wroclaw Medical University
https://www.readbyqxmd.com/read/29442463/knowledge-and-selected-variables-as-determinants-of-the-quality-of-life-and-general-health-of-patients-with-rheumatoid-arthritis
#7
Aleksandra Pytel, Iwona Demczyszak, Edyta Sutkowska, Joanna Rosińczuk, Izabela Kuberka, Aleksandra Kołtuniuk
BACKGROUND: Rheumatoid arthritis (RA) is an incurable disease resulting in progressive disability, which is associated with the loss of productivity and the inability to earn money, which might lead to a financial burden on the patient's family. Undoubtedly, the clinical picture of the disease and its consequences lead to the reduction of the quality of life. OBJECTIVES: The aim of this study is to evaluate the influence of selected factors on the subjective assessment of the quality of life and general health of patients with RA...
December 2017: Advances in Clinical and Experimental Medicine: Official Organ Wroclaw Medical University
https://www.readbyqxmd.com/read/29442462/biologically-active-form-of-vitamin-b1-in-human-peritoneal-effluent
#8
Magdalena Jankowska, Monika Lichodziejewska-Niemierko, Sylwia Małgorzewicz, Bolesław Rutkowski
BACKGROUND: Supplementation with vitamin B1 protects the peritoneal membrane from inflammatory and oxidative insults and preserves residual kidney function in rat models of peritoneal dialysis (PD). It is assumed that an active form of vitamin B1, thiamin diphosphate (ThDP), is responsible for this protective effect. However, it has never been shown whether ThDP, a compound known not to cross cellular membranes, is actually detectable in human peritoneal effluent. OBJECTIVES: This study was designed to investigate the concentration, appearance rate, and daily loss of ThDP in the peritoneal effluent of patients treated with PD...
December 2017: Advances in Clinical and Experimental Medicine: Official Organ Wroclaw Medical University
https://www.readbyqxmd.com/read/29442461/central-aortic-pressure-arterial-stiffness-and-echocardiographic-parameters-of-children-with-overweight-obesity-and-arterial-hypertension
#9
Jerzy Wójtowicz, Aleksandra Łempicka, Włodzimierz Łuczyński, Wojciech Szczepański, Aleksandra Zomerfeld, Kornel Semeran, Artur Bossowski
BACKGROUND: A non-invasive estimation of central aortic pressure and echocardiographic parameters, and appropriate interpretation thereof make it possible to determine the status of the vascular wall and myocardium. These parameters are early markers of unfavorable remodeling of the cardiovascular system. OBJECTIVES: The aim of this study was to analyze the central aortic pressure and echocardiographic parameters of overweight/obese children (with or without concomitant arterial hypertension)...
December 2017: Advances in Clinical and Experimental Medicine: Official Organ Wroclaw Medical University
https://www.readbyqxmd.com/read/29442460/do-medical-students-adhere-to-advice-regarding-a-healthy-lifestyle-a-pilot-study-of-bmi-and-some-aspects-of-lifestyle-in-medical-students-in-poland
#10
Dominika Kanikowska, Dorota Sikorska, Barbara Kuczyńska, Marian Grzymisławski, Andrzej Bręborowicz, Janusz Witowski
BACKGROUND: The components of lifestyle of medical students, with comprehensive reporting of their physical activity and drinking and eating behavior, are rarely evaluated. Being overweight (increased body mass index - BMI) is associated with health problems, an unhealthy lifestyle (inadequate sleep, diet and exercise) being implicated. OBJECTIVES: The aim was to determine if there were discrepancies between assessments of actual lifestyle and advice regarding the principles of a healthy lifestyle...
December 2017: Advances in Clinical and Experimental Medicine: Official Organ Wroclaw Medical University
https://www.readbyqxmd.com/read/29442459/the-usefulness-of-routinely-used-malnutrition-screening-tools-in-predicting-anemia-in-lung-cancer-patients
#11
Katarzyna A Zabłocka-Słowińska, Monika Kosacka, Irena Porębska, Konrad Pawełczyk, Marcin Gołecki, Jadwiga Biernat, Halina Grajeta
BACKGROUND: Anemia and malnutrition are frequently observed during lung cancer development, and the associations between them have been researched. However, no study concerning the utility of routinely used nutritional screening tools in predicting anemia in lung cancer has been performed. OBJECTIVES: The aim of this study was to assess the usefulness of routinely used malnutrition screening tools in predicting anemia in lung cancer patients. MATERIAL AND METHODS: Eighty-five male patients were recruited to this study...
December 2017: Advances in Clinical and Experimental Medicine: Official Organ Wroclaw Medical University
https://www.readbyqxmd.com/read/29442458/the-influence-of-vitamin-d-deficiency-on-eradication-rates-of-helicobacter-pylori
#12
Oguzhan Yildirim, Tulay Yildirim, Yuksel Seckin, Pelin Osanmaz, Yilmaz Bilgic, Rafet Mete
BACKGROUND: Helicobacter pylori eradication therapy improves the healing of various gastro-duodenal diseases such as chronic gastritis and peptic ulcer, and also reduces gastric cancer incidence. Several studies have reported on risk factors other than antibiotic resistance related to Helicobacter pylori eradication failure. OBJECTIVES: In this study, we aimed to investigate whether or not the serum levels of 25-hydroxy-vitamin D (25(OH)D) influence eradication rates of H...
December 2017: Advances in Clinical and Experimental Medicine: Official Organ Wroclaw Medical University
https://www.readbyqxmd.com/read/29442457/dietary-patterns-and-breast-or-lung-cancer-risk-a-pooled-analysis-of-2-case-control-studies-in-north-eastern-poland
#13
Beata Krusińska, Iwona Hawrysz, Małgorzata A Słowińska, Lidia Wądołowska, Maciej Biernacki, Anna Czerwińska, Janusz J Gołota
BACKGROUND: Breast cancer in women and lung cancer in men are the most prevalent cancers in Poland and worldwide. Evidence of the impact of food groups and nutrients on the risk of breast and lung cancer is limited and lacking conclusions. Studies on food consumption and breast or lung cancer are limited. OBJECTIVES: Assessment of the association between dietary patterns and the prevalence of breast and lung cancers in adult Poles. MATERIAL AND METHODS: The study involved a pooled analysis of 2 case-control studies on 320 subjects aged 50-70 years from north-eastern Poland (160 women, 160 men)...
December 2017: Advances in Clinical and Experimental Medicine: Official Organ Wroclaw Medical University
https://www.readbyqxmd.com/read/29442456/an-inverse-relationship-between-plasma-glutathione-concentration-and-fasting-glycemia-in-patients-with-coronary-artery-disease-and-concomitant-type-2-diabetes-a-pilot-study
#14
Kamil Karolczak, Paweł Kubalczyk, Rafał Głowacki, Robert Pietruszyński, Cezary Watała
BACKGROUND: There have been occasional reports indicating that plasma concentrations of reduced glutathione (GSH) may be associated in some way with blood glucose. This relationship, however, has not hitherto been explored in the blood plasma of patients with coronary artery disease (CAD). OBJECTIVES: The aim of this study was to evaluate potential associations of fasting glycemia and peripheral blood plasma GSH concentrations in CAD-free and CAD-affected subjects...
December 2017: Advances in Clinical and Experimental Medicine: Official Organ Wroclaw Medical University
https://www.readbyqxmd.com/read/29442455/oral-mucositis-and-saliva-iga-igg-and-igm-concentration-during-anti-tumor-treatment-in-children-suffering-from-acute-lymphoblastic-leukemia
#15
Elżbieta J Pels
BACKGROUND: Oral mucositis is a problem occurring within the oral cavity, which is the most difficult to deal with during anti-tumor treatment. The first symptom reported by the patient is discomfort. Salivary immunoglobulins play an important role in pathological processes occurring in the oral cavity. OBJECTIVES: The study objective was to assess the occurrence of oral mucositis and to assess changes in the saliva IgA, IgG, and IgM concentration in children with acute lymphoblastic leukemia during antitumor treatment...
December 2017: Advances in Clinical and Experimental Medicine: Official Organ Wroclaw Medical University
https://www.readbyqxmd.com/read/29442454/higher-concentrations-of-osteoprotegerin-in-type-1-diabetic-patients-are-related-to-retinopathy-results-from-the-pozna%C3%A5-prospective-study
#16
Agata Grzelka, Dariusz Naskręt, Aleksandra Araszkiewicz, Aleksandra Uruska, Małgorzata Wegner, Dorota Zozulińska-Ziółkiewicz
BACKGROUND: Osteoprotegerin (OPG) is an arterial calcification marker which has been associated with vascular damage. Elevated OPG concentrations associated with low-grade inflammatory processes are found in diabetic subjects. OBJECTIVES: The aim of the study was to assess concentrations of OPG in relation to the presence of diabetic complications in patients with diabetes type 1 (DM 1) participating in the Poznań Prospective Study (PoProStu). MATERIAL AND METHODS: The study included 74 patients with DM1 (48 men) with a median age of 39 years (interquartile range [IQR]: 34-43) and a median 15-year history (IQR: 14-16) of diabetes, who were participants in the PoProStu...
December 2017: Advances in Clinical and Experimental Medicine: Official Organ Wroclaw Medical University
https://www.readbyqxmd.com/read/29442453/transcriptomic-analysis-of-the-pi3k-akt-signaling-pathway-reveals-the-dual-role-of-the-c-jun-oncogene-in-cytotoxicity-and-the-development-of-resistance-in-hl-60-leukemia-cells-in-response-to-arsenic-trioxide
#17
Joanna Roszak, Anna Smok-Pieniążek, Maciej Stępnik
BACKGROUND: Arsenic trioxide (ATO) is a well-recognized antileukemic drug used for the treatment of newly diagnosed and relapsed acute promyelocytic leukemia (APL). A major drawback of therapy with ATO is the development of APL cell resistance, the mechanisms of which are still not clear. OBJECTIVES: The aim of this study was to investigate the role of the PI3K/Akt signaling pathway in ATOtreated human acute myeloid leukemia (HL-60) cells and in ATO-resistant clones...
December 2017: Advances in Clinical and Experimental Medicine: Official Organ Wroclaw Medical University
https://www.readbyqxmd.com/read/29442452/the-neuroprotective-effect-of-n-acetylcysteine-in-spinal-cord-injured-rats
#18
Edyta Olakowska, Wiesław Marcol, Adam Właszczuk, Izabella Woszczycka-Korczyńska, Joanna Lewin-Kowalik
BACKGROUND: Spinal cord injury (SCI) is an important cause of impairment of sensory and motor nerve function. It has been shown that free-radical species play an important role in the pathogenesis of acute tissue trauma after SCI. There are no proven pharmacological therapies that provide neuroprotection and stimulate axonal growth after trauma. OBJECTIVES: The aim of this study was to investigate the neuroprotective effect of N-acetylcysteine (NAC) on the regeneration of spinal cord injuries in rats...
December 2017: Advances in Clinical and Experimental Medicine: Official Organ Wroclaw Medical University
https://www.readbyqxmd.com/read/29442451/application-of-an-anionic-polymer-in-the-formulation-of-floating-tablets-containing-an-alkaline-model-drug
#19
Dorota Wójcik-Pastuszka, Iwona Golonka, Andrzej Drys, Jobst B Mielck, Maria Twarda, Witold Musiał
BACKGROUND: Gastric residence time is the key factor affecting the bioavailability of active pharmaceutical ingredients absorbed mainly through the gastric mucous membrane and influencing the local activity of some drugs. OBJECTIVES: The aim of this study was the development of a new composition of non-effervescent floating tablets and the evaluation of the effect of an anionic polymer and compressive force on the floating properties and release characteristics of tablets containing a model alkaline drug, chlorhexidine (CHX)...
December 2017: Advances in Clinical and Experimental Medicine: Official Organ Wroclaw Medical University
https://www.readbyqxmd.com/read/29264890/the-treatment-of-facial-asymmetry-review
#20
REVIEW
Kazimierz Kobus, Katarzyna Kobus-Zaleśna
Some degree of congenital or acquired asymmetry is normal and universal. Significant facial asymmetry, however, causes both aesthetic, as well as functional problems. The comprehensive management of facial symmetry is scarcely addressed.1-5 Differing etiologies, heterogeneous material, and different ages of patients tend to produce fragmentary reports, the more so as evidence-based evaluation of outcomes is almost impossible. Therefore, a presentation of the general rules of treatment, illustrated by our own material collected from the Hospital and Clinic of Plastic Surgery in Polanica-Zdrój and from private surgical and orthodontic practice, could be regarded as useful and justified...
November 2017: Advances in Clinical and Experimental Medicine: Official Organ Wroclaw Medical University
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