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Advances in Clinical and Experimental Medicine: Official Organ Wroclaw Medical University

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https://www.readbyqxmd.com/read/28028990/acquired-von-willebrand-syndrome
#1
REVIEW
Andrzej Mital
Acquired von Willebrand syndrome is a rare hemorrhagic diathesis, with clinical symptoms similar to those associated with the inherited form von Willebrand disease. This syndrome is characterized by a lack of previous bleeding symptoms, negative familial history, and occurrence in a relatively older age. Most commonly, acquired von Willebrand syndrome develops in the course of other conditions, such as lymphoproliferative, myeloproliferative, cardiovascular and autoimmune disorders; additionally, it can be associated with some non-hematological malignancies and use of certain prescription drugs...
November 2016: Advances in Clinical and Experimental Medicine: Official Organ Wroclaw Medical University
https://www.readbyqxmd.com/read/28028989/thymosin-%C3%AE-as-an-actin-binding-protein-with-a-variety-of-functions
#2
REVIEW
Aleksandra Kuzan
According to current data, the thymosin β family is composed of 20 short (40-44 amino acid) peptides, but in a healthy human body only 2 are expressed - thymosin β4 and β10. Their most characteristic feature is the ability to form a complex with monomeric actin, thereby preventing polymerization into a filamentous form, hence the name Actin-Binding Protein (ABP). These peptides play numerous different functions. Among others, they affect the processes of carcinogenesis, differentiation and angiogenesis, influence metalloproteinase activity and accelerate wound healing...
November 2016: Advances in Clinical and Experimental Medicine: Official Organ Wroclaw Medical University
https://www.readbyqxmd.com/read/28028988/direct-oral-anticoagulants-in-patients-with-thrombophilia-challenges-in-diagnostic-evaluation-and-treatment
#3
REVIEW
Anetta Undas, Tadeusz Góralczyk
Direct oral anticoagulants (DOACs) or non-vitamin K oral anticoagulants (NOACs) are increasingly used in the prevention of recurrent venous thromboembolism (VTE), including that associated with thrombophilia. The efficacy of DOACs in thrombophilic patients, especially those with severe trombophilia or triple positive antiphospholipid syndrome (APS) with arterial thromboembolic events, remains controversial. Most case reports and case series indicate that DOACs are an attractive therapeutic option in the vast majority of these patients at high risk of recurrent VTE with more concerns raised in high-risk APS patients and these deficient in protein S (PS)...
November 2016: Advances in Clinical and Experimental Medicine: Official Organ Wroclaw Medical University
https://www.readbyqxmd.com/read/28028987/evaluation-of-the-erosive-potential-of-selected-isotonic-drinks-in-vitro-studies
#4
Aneta Ostrowska, Witold Szymański, Łukasz Kołodziejczyk, Elżbieta Bołtacz-Rzepkowska
BACKGROUND: Isotonic drinks are an important component of the diet of athletes. Sports drinks cause the body to maintain proper hydration and supplement minerals which are lost in sweat during excessive exercising. Aside from the benefits of isotonic drinks, it is important to be aware of the harmful effects of citric acid within the products, which could cause enamel erosion. OBJECTIVES: The aim of the study was to evaluate the erosive potential of sports drinks using confocal scanning laser microscopy (CLSM)...
November 2016: Advances in Clinical and Experimental Medicine: Official Organ Wroclaw Medical University
https://www.readbyqxmd.com/read/28028986/objectification-of-orthodontic-treatment-needs-does-the-classification-of-malocclusions-or-a-history-of-orthodontic-treatment-matter
#5
Anna Kozanecka, Michał Sarul, Beata Kawala, Joanna Antoszewska-Smith
BACKGROUND: Orthodontic classifications make it possible to give an accurate diagnosis but do not indicate an objective orthodontic treatment need. In order to evaluate the need for treatment, it is necessary to use such indicators as the IOTN. OBJECTIVES: The aim of the study was to find (i) relationships between individual diagnosis and objective recommendations for treatment and (ii) an answer to the question whether and which occlusal anomalies play an important role in the objectification of treatment needs...
November 2016: Advances in Clinical and Experimental Medicine: Official Organ Wroclaw Medical University
https://www.readbyqxmd.com/read/28028985/using-an-electron-scanning-microscope-to-assess-the-penetrating-abilities-of-an-experimental-preparation-with-features-of-a-dental-infiltrant-preliminary-study
#6
Małgorzata Skucha-Nowak, Anna Mertas, Marta Tanasiewicz
BACKGROUND: The resin infiltration technique is one of the micro-invasive methods whose aim is the penetration of demineralized enamel with a low viscosity resin. This technique allows the dentist to avoid the application of mechanical means of treatment. OBJECTIVES: The objective of this preliminary study was to attempt to determine the possibilities of using an electron microscope to assess the penetrating abilities of an experimental preparation with features of a dental infiltrant and to compare the depth of infiltration of the designed experimental preparation with an infiltrant available on the market...
November 2016: Advances in Clinical and Experimental Medicine: Official Organ Wroclaw Medical University
https://www.readbyqxmd.com/read/28028984/whole-body-cryostimulation-as-an-effective-method-of-reducing-oxidative-stress-in-healthy-men
#7
Agata Stanek, Karolina Sieroń-Stołtny, Ewa Romuk, Armand Cholewka, Tomasz Wielkoszyński, Grzegorz Cieślar, Sebastian Kwiatek, Aleksander Sieroń, Aleksandra Kawczyk-Krupka
BACKGROUND: Whole-body cryostimulation (WBC) is the therapeutic exposure of the total human body (without underwear) to a very low temperature (below -100°C) for 120-180 s. Currently, WBC is used more frequently not only in the treatment of patients suffering from various diseases, but also by healthy people as a wellness method. OBJECTIVES: The aim of this research is to evaluate the impact of WBC procedures on oxidative stress parameters in healthy men. MATERIAL AND METHODS: The study involved 32 healthy male subjects who were randomly divided into 2 groups: 16 men exposed to WBC procedures with subsequent kinesiotherapy (WBC group) and 16 men exposed only to kinesiotherapy procedures (KT group)...
November 2016: Advances in Clinical and Experimental Medicine: Official Organ Wroclaw Medical University
https://www.readbyqxmd.com/read/28028983/monitoring-of-circulating-tumor-cells-by-a-combination-of-immunomagnetic-enrichment-and-rt-pcr-in-colorectal-cancer-patients-undergoing-surgery
#8
Gabriela Vojtechova, Lucie Benesova, Barbora Belsanova, Petra Minarikova, Miroslav Levy, Ludmila Lipska, Stepan Suchanek, Miroslav Zavoral, Marek Minarik
BACKGROUND: The presence of circulating tumor cells (CTC) has been reported in patients with advanced colorectal cancer. Monitoring CTC (also known as a liquid-biopsy) has recently become the center of interest for low-invasive monitoring of cancer progression and predictive biomarkers testing. Along with high-cost technology and a complex methodology, a straightforward method based on magnetic beads enrichment followed by RT-PCR is set to allow for routine CTC analysis in colorectal cancer patients...
November 2016: Advances in Clinical and Experimental Medicine: Official Organ Wroclaw Medical University
https://www.readbyqxmd.com/read/28028982/secondary-aortoenteric-fistula-after-abdominal-aortic-graft-implementation-in-our-own-material
#9
Jan Gnus, Stanisław Ferenc, Magdalena Kościelna, Małgorzata Paprocka-Borowicz, Piotr Dawidczyk, Małgorzata Dziewiszek, Wojciech Witkiewicz
BACKGROUND: Secondary aortoenteric fistula is a rare but severe complication occurring after abdominal aortic graft implementation. OBJECTIVES: The aim of our study was to review the clinical presentation, diagnosis and postoperative course of patients with aortoenteric fistulas following vascular operations on the abdominal aorta in the years 2000-2014. MATERIAL AND METHODS: Among all the patients treated in our center, during a 10-year period, aortoenteric fistulas were observed in 24 cases...
November 2016: Advances in Clinical and Experimental Medicine: Official Organ Wroclaw Medical University
https://www.readbyqxmd.com/read/28028981/assessment-of-selected-rotem-parameters-kinetics-of-fibrinogen-polymerization-and-plasmin-amidolytic-activity-in-patients-with-congenital-fibrinogen-defects
#10
Jacek Treliński, Katarzyna Pachniewska, Justyna Matczak, Marta Robak, Krzysztof Chojnowski
BACKGROUND: Congenital fibrinogen disorders (CFD) are rare fibrinogen deficiencies which may be quantitative or functional. The clinical course of hypofibrinogenemia (hypoFI) or dysfibrinogenemia (dysFI) is unpredictable and cannot be determined by the application of standard hemostasis tests. OBJECTIVES: The main aim of this study was to assess ROTEM parameters in CFD patients. MATERIAL AND METHODS: Nine patients with CFD were studied. The fibrinogen concentration was measured functionally and antigenically...
November 2016: Advances in Clinical and Experimental Medicine: Official Organ Wroclaw Medical University
https://www.readbyqxmd.com/read/28028980/normal-values-for-heart-electrophysiology-parameters-of-healthy-swine-determined-on-electrophysiology-study
#11
Agnieszka Noszczyk-Nowak, Alicja Cepiel, Adrian Janiszewski, Robert Pasławski, Jacek Gajek, Urszula Pasławska, Józef Nicpoń
BACKGROUND: Swine are a well-recognized animal model for human cardiovascular diseases. Despite the widespread use of porcine model in experimental electrophysiology, still no reference values for intracardiac electrical activity and conduction parameters determined during an invasive electrophysiology study (EPS) have been developed in this species thus far. OBJECTIVES: The aim of the study was to develop a set of normal values for intracardiac electrical activity and conduction parameters determined during an invasive EPS of swine...
November 2016: Advances in Clinical and Experimental Medicine: Official Organ Wroclaw Medical University
https://www.readbyqxmd.com/read/28028979/a-controlled-trial-of-the-efficacy-of-a-training-walking-program-in-patients-recovering-from-abdominal-aortic-aneurysm-surgery
#12
Bartosz R Wnuk, Jacek Durmała, Krzysztof Ziaja, Przemysław Kotyla, Marek Woźniewski, Edward Błaszczak
BACKGROUND: Major surgical procedures as well as general anesthesia contribute to muscle weakness and posture instability and may result in increased postoperative complications and functional disorders resulting from an elective operation. OBJECTIVES: We aim to state the significance of backward walking as a form of interval march training with patients after abdominal aortic aneurysm surgery. MATERIAL AND METHODS: Sixty-five patients were randomly divided into three subgroups and three various models of physiotherapy were applied...
November 2016: Advances in Clinical and Experimental Medicine: Official Organ Wroclaw Medical University
https://www.readbyqxmd.com/read/28028978/determination-of-selected-amino-acids-in-serum-of-patients-with-liver-disease
#13
Roman Kanďár, Petra Drábková, Tereza Toiflová, Alexander Čegan
BACKGROUND: The determination of amino acids can be a reliable approach for extended diagnosis of liver diseases. This is because liver disease can be a cause of impaired amino acid metabolism. Therefore, a method for the determination of serum amino acids, applicable for clinical purposes, is necessary. OBJECTIVES: The aim of this study was to find differences in the levels of selected amino acids between patients with liver disease and a control group. MATERIAL AND METHODS: Samples of peripheral venous blood were obtained from a group of patients with liver disease (n = 131, 59 women at an average age of 60 years and 72 men at an average age of 52 years) and a control group (n = 105, 47 women at an average age of 62 years and 58 men at an average age of 58 years)...
November 2016: Advances in Clinical and Experimental Medicine: Official Organ Wroclaw Medical University
https://www.readbyqxmd.com/read/28028977/the-effectiveness-of-corticosteroid-usage-in-complex-therapy-for-severe-sepsis-and-acute-respiratory-distress-syndrome-in-cases-of-severe-traumatic-brain-injury
#14
Oleksandr V Oliynyk, Bohdana O Pereviznyk, Oleh V Yemiashev, Anna Shlifirchyk
BACKGROUND: Severe traumatic brain injury (STBI) is an important issue in contemporary medicine and treatment strategies are still in need of improvement. The most dangerous complications of STBI are multiple organ failure and severe sepsis. As many as 80% of STBI patients with multiple organ failure have acute respiratory distress syndrome (ARDS). The need for better treatment strategies for STBI has led to investigations of the positive therapeutic effects of corticosteroids (CS). About 10 to 15 years ago research showed the inexpediency of CS in STBI therapy, but there were also contradictory findings showing their effectiveness...
November 2016: Advances in Clinical and Experimental Medicine: Official Organ Wroclaw Medical University
https://www.readbyqxmd.com/read/28028976/evaluating-the-hearing-of-patients-with-pseudoexfoliation-syndrome
#15
Hanna Temporale, Anna Karasińska-Kłodowska, Anna Turno-Kręcicka, Monika Morawska-Kochman, Karolina Dorobisz, Krzysztof Dudek, Marta Misiuk-Hojło, Tomasz Kręcicki
BACKGROUND: It is estimated that pseudoexfoliation syndrome (PEX) occurs in 10-20% of the general population over 60 years of age, and its morbidity increases with age. Some research indicates that PEX may be a systemic disease. Some experts state that it can also lead to ear dysfunction. OBJECTIVES: The aim of the study was to evaluate the incidence and type of hearing disorders in patients with PEX. MATERIAL AND METHODS: The study included 51 patients (102 eyes) hospitalized in Wroclaw Medical University Hospital's Department of Ophthalmology and scheduled for cataract surgery in 2012-2014...
November 2016: Advances in Clinical and Experimental Medicine: Official Organ Wroclaw Medical University
https://www.readbyqxmd.com/read/28028975/impact-of-birth-weight-and-smoking-on-lung-function-in-patients-with-asthma-copd-and-healthy-volunteers
#16
Bernard Panaszek, Robert Pawłowicz, Karolina Lindner, Rafał Dobek, Konrad Panaszek, Andrzej Obojski, Joanna Rosińczuk, Jerzy Ichnowski
BACKGROUND: Birth weight (BW) is an important factor for determining the development of the respiratory system. The majority of research analyzed the impact of BW on lung function in youth. BW influence and smoking on lung function in adults with asthma and COPD is an interesting issue. OBJECTIVES: The aim of the study was to investigate relationships between BW, smoking, and lung function in adult healthy individuals and diagnosed with asthma or COPD. MATERIAL AND METHODS: Four hundred seventy-nine subjects were divided into 5 groups: 123 healthy non-smokers, 180 healthy smokers, 72 non-smoking asthmatics, 57 smoking asthmatics, and 47 COPD patients...
November 2016: Advances in Clinical and Experimental Medicine: Official Organ Wroclaw Medical University
https://www.readbyqxmd.com/read/28028974/myocardial-ischaemia-coronary-atherosclerosis-and-pulmonary-pressure-elevation-in-antiphospholipid-syndrome-patients
#17
Agnieszka Padjas, Wojciech Płazak, Magdalena Celińska-Lowenhoff, Adam Mazurek, Carlo Perricone, Piotr Podolec, Jacek Musiał
BACKGROUND: Thrombotic events in antiphospholipid syndrome (APS) involve venous and arterial circulation with the possible involvement of coronary or pulmonary microcirculation. OBJECTIVES: To evaluate the influence of antiphospholipid antibodies (aPL) and on myocardial ischaemia assessed by single-photon emission computerized tomography (SPECT), coronary atherosclerosis assessed by multidetector computerized tomography (MDCT) and pulmonary pressure assessed by transthoracic echocardiography (TTE) in patients with primary antiphospholipid syndrome (PAPS)...
November 2016: Advances in Clinical and Experimental Medicine: Official Organ Wroclaw Medical University
https://www.readbyqxmd.com/read/28028973/the-impact-of-0-9-nacl-on-mesothelial-cells-after-intraperitoneal-lavage-during-surgical-procedures
#18
Jarosław Cwaliński, Andrzej Bręborowicz, Alicja Połubińska
BACKGROUND: Normal saline gained wide popularity in abdominal surgery as a basic compound used in intraoperative drainage of the peritoneal cavity. However, recent studies have revealed that saline solution is not quite biocompatible with the intraperitoneal enviroment and may promote peritoneal adhesions. OBJECTIVES: The aim of the study was to evaluate the function and viability of human mesothelial cells cultured in vitro in 0.9% NaCl solution from intraperitoneal lavage carried out during laparoscopic cholecytectomies...
November 2016: Advances in Clinical and Experimental Medicine: Official Organ Wroclaw Medical University
https://www.readbyqxmd.com/read/28028972/positron-emission-tomography-scanning-in-the-management-of-hodgkin-lymphoma-patients-a-single-institution-experience
#19
Ewa Zabrocka, Ewa Sierko, Marek Z Wojtukiewicz
BACKGROUND: Positron emission tomography (PET-CT) has become a valuable implement in the management of Hodgkin lymphoma (HL). However, since PET-CT is a relatively new imaging method, its capabilities have not been fully explored. OBJECTIVES: The aim of the study was to evaluate the role of PET-CT at different points in HL management. MATERIAL AND METHODS: The medical documentation of 47 HL patients treated at the Comprehensive Cancer Center in Białystok, Poland, was analyzed retrospectively...
November 2016: Advances in Clinical and Experimental Medicine: Official Organ Wroclaw Medical University
https://www.readbyqxmd.com/read/28028971/assessment-of-pain-when-uncovering-implants-with-er-yag-laser-or-scalpel-for-second-stage-surgery
#20
Jacek Matys, Marzena Dominiak
BACKGROUND: Different methods aimed at decreasing pain during some soft tissue procedures in dentistry are still under research. Modern devices as lasers could be a method to reduce the pain and duration of second stage implant surgery. OBJECTIVES: To assess the pain and the impression quality when uncovering implants with a laser and with a scalpel. MATERIAL AND METHODS: The analysis included 60 implants (Dentium SuperLine, Suwon, Korea) in 30 patients (23 women and 7 men) aged 25-69...
November 2016: Advances in Clinical and Experimental Medicine: Official Organ Wroclaw Medical University
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