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Advances in Clinical and Experimental Medicine: Official Organ Wroclaw Medical University

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https://www.readbyqxmd.com/read/29912482/increasing-beta-cell-mass-to-treat-diabetes-mellitus
#1
REVIEW
Shakila Sabir, Ammara Saleem, Muhammad Furqan Akhtar, Muhammad Saleem, Moosa Raza
Finding a radical cure for diabetes has reached paramount importance in medicine due to the widespread prevalence of the disease. A substantial reduction in insulin-secreting beta cells is evident in diabetes. The failure of cyclin-dependent kinases (CDKs) and cyclins to access the nucleus is responsible for quiescence or senescence in human and rodent beta cells. The augmentation of beta cell proliferation is supposed to reverse diabetes. This concept has inspired the discovery of newer drugs that encourage the proliferation of beta cells...
June 18, 2018: Advances in Clinical and Experimental Medicine: Official Organ Wroclaw Medical University
https://www.readbyqxmd.com/read/29912481/osseointegration-of-zirconia-implants-with-3-varying-surface-textures-and-a-titanium-implant-a-histological-and-micro-ct-study
#2
Paweł Kubasiewicz-Ross, Jakub Hadzik, Marzena Dominiak
BACKGROUND: Zirconium - a bioinert metal - in comparison with titanium implants, offers a variety of potential advantages for use in the esthetic area of dentistry due to its tooth-like color. Zirconium dental implants are considered to be an alternative method of treatment to conventional titanium dental implants for patients with a thin gingival biotype. OBJECTIVES: This study was designed to study the bone tissue response to new zirconia implants with modified surfaces in comparison with commercially available titanium dental implants and commercially available zirconia implants...
June 18, 2018: Advances in Clinical and Experimental Medicine: Official Organ Wroclaw Medical University
https://www.readbyqxmd.com/read/29912480/opioidergic-conditioning-of-the-human-heart-muscle-in-nitric-oxide-dependent-mechanism
#3
Marcin Kunecki, Tomasz Roleder, Jolanta Biernat, Paweł Kukla, Lidia Tomkiewicz-Pająk, Marek A Deja, Piotr Podolec, Krzysztof S Gołba, Wojciech Płazak
BACKGROUND: Opioidergic conditioning is well documented to trigger cardioprotection against ischemia/ reperfusion (I/R) injury. Previous studies on animal models have suggested that nitric oxide (NO) mediates the beneficial effect of opioids, but the role of NO in humans seems to be controversial. OBJECTIVES: The aim of the study was to assess the influence of NO modulators on opioid-induced cardioprotection in the human myocardium. MATERIAL AND METHODS: Trabeculae of the human right atria were electrically driven in an organ bath and subjected to simulated I/R injury...
June 18, 2018: Advances in Clinical and Experimental Medicine: Official Organ Wroclaw Medical University
https://www.readbyqxmd.com/read/29911750/use-of-mthfr-c677t-polymorphism-and-plasma-pharmacokinetics-to-predict-methotrexate-toxicity-in-patients-with-acute-lymphoblastic-leukemia
#4
Lobna Ben Mahmoud, Moez Mdhaffar, Rim Frikha, Hanen Ghozzi, Ahmed Hakim, Zouheir Sahnoun, Moez Elloumi, Khaled Zeghal
BACKGROUND: Methotrexate (MTX) is a key component of acute lymphoblastic leukemia (ALL) therapy, but it is associated with serious toxicities in a considerable number of patients. OBJECTIVES: The aim of the current study was to determine which variables were associated with MTX toxicity in children, adolescents and young adults with ALL. MATERIAL AND METHODS: In this prospective study, 35 patients with newly diagnosed ALL, treated according to the 58951 European Organization for Research and Treatment of Cancer - Children's Leukemia Group (EORTC-CLG) protocol, were prospectively enrolled...
June 18, 2018: Advances in Clinical and Experimental Medicine: Official Organ Wroclaw Medical University
https://www.readbyqxmd.com/read/29911749/electrocardiographic-abnormalities-in-amateur-male-marathon-runners
#5
Anna M Kaleta, Ewa Lewicka, Alicja Dąbrowska-Kugacka, Zuzanna Lewicka-Potocka, Elżbieta Wabich, Anna Szerszyńska, Julia Dyda, Jakub Sobolewski, Jakub Koenner, Grzegorz Raczak
BACKGROUND: Sports activity has become extremely popular among amateurs. Electrocardiography is a useful tool in screening for cardiac pathologies in athletes; however, there is little data on electrocardiographic abnormalities in the group of amateur athletes. OBJECTIVES: The aim of this study was to analyze the abnormalities in resting and exercise electrocardiograms (ECGs) in a group of amateur athletes, and try to determine whether the criteria applied for the general population or for athletes' ECGs should be implemented in this group...
June 18, 2018: Advances in Clinical and Experimental Medicine: Official Organ Wroclaw Medical University
https://www.readbyqxmd.com/read/29905987/risk-factors-of-the-clostridium-difficile-infection-in-patients-with-chronic-kidney-disease
#6
Łukasz Lis, Patryk Jerzak, Andrzej Konieczny, Michał Sroka, Barbara Noceń-Rychlewska, Paweł Podgórski, Wojciech Witkiewicz, Zbigniew Hruby
BACKGROUND: Clostridium difficile (C. difficile) is a Gram-positive bacillus responsible for diarrhea and colitis, mainly among hospitalized patients. It is a leading cause of nosocomial infections. OBJECTIVES: The main goal of the study was to assess the risk factors of the C. difficile infection in patients with chronic kidney disease (CKD). MATERIAL AND METHODS: We evaluated the medical records of all patients treated at the Department of Nephrology and Renal Transplantation of the Research and Development Center in the Provincial Specialist Hospital in Wrocław, Poland, between February 2009 and May 2012, who developed diarrhea, abdominal pain and/or fever within 72 h after admission...
June 15, 2018: Advances in Clinical and Experimental Medicine: Official Organ Wroclaw Medical University
https://www.readbyqxmd.com/read/29905413/pik3ca-mutation-in-gastric-cancer-and-the-role-of-microsatellite-instability-status-in-mutations-of-exons-9-and-20-of-the-pik3ca-gene
#7
Karol Polom, Daniele Marrelli, Giandomenico Roviello, Valeria Pascale, Costantino Voglino, Carla Vindigni, Daniele Generali, Franco Roviello
BACKGROUND: A better understanding of molecular gastric cancer (GC) entities may help in tailored treatments of that neoplasm. The PIK3CA mutation is one of the most important in many cancers. Objectives. We performed a comparison of clinical and pathological data of the PIK3CA mutation in GC patients. MATERIAL AND METHODS: The analysis was done on 472 patients operated on in one center. Polymerase chain reaction (PCR) was used for the screening of PIK3CA (exon 9 and 20)...
June 15, 2018: Advances in Clinical and Experimental Medicine: Official Organ Wroclaw Medical University
https://www.readbyqxmd.com/read/29905412/myeloid-derived-suppressor-cell-accumulation-in-renal-cell-carcinoma-is-correlated-with-ccl2-il-17-and-il-18-expression-in-blood-and-tumors
#8
Xiaodong Guan, Zhiyu Liu, Jianhua Zhang, Xunbo Jin
BACKGROUND: Myeloid-derived suppressor cells (MDSC) play an important role in tumor-mediated immune evasion. Levels of MDSC in peripheral blood are increased in patients with cancer, correlating with cancer stage and outcome. Studies have confirmed the associations between MDSC and various cytokines in the peripheral blood of murine and human cancer hosts. However, little is known about the association between parenchymal MDSC subsets and cytokines, or the mechanism drawing MDSC into tumor parenchyma...
June 15, 2018: Advances in Clinical and Experimental Medicine: Official Organ Wroclaw Medical University
https://www.readbyqxmd.com/read/29905411/anti-inflammatory-and-antioxidant-effects-of-mesenchymal-and-hematopoietic-stem-cells-in-a-rheumatoid-arthritis-rat-model
#9
Hanan Abdelmawgoud, Asmaa Saleh
BACKGROUND: Mesenchymal stem cells (MSCs) are of increased importance because of their capacity to counteract inflammation and suppress host immune responses. OBJECTIVES: The aim of the study was to compare the effectiveness of MSCs and hematopoietic stem cells (HSCs) in the treatment of rheumatoid arthritis (RA). MATERIAL AND METHODS: Paw swelling was assessed by measuring the thickness of the hind paws using a caliper. Cytokines - interleukin (IL)-6, tumor necrosis factor-alpha (TNF-α), transforming growth factor-beta (TGF-β), and IL-10 - and rheumatoid factor (RF) were measured using enzyme-linked immunosorbent assay (ELISA) kits...
June 15, 2018: Advances in Clinical and Experimental Medicine: Official Organ Wroclaw Medical University
https://www.readbyqxmd.com/read/29905407/pathophysiological-implications-of-actin-free-gc-globulin-concentration-changes-in-blood-plasma-and-cerebrospinal-fluid-collected-from-patients-with-alzheimer-s-disease-and-other-neurological-disorders
#10
Alina Kułakowska, Joanna Tarasiuk, Katarzyna Kapica-Topczewska, Monika Chorąży, Robert Pogorzelski, Agnieszka Kulczyńska-Przybik, Barbara Mroczko, Robert Bucki
BACKGROUND: The extracellular actin scavenging system (EASS) is composed of plasma Gc-globulin and gelsolin, and is responsible for the elimination of toxic actin from the bloodstream. OBJECTIVES: In this study, we assessed the actin-free Gc-globulin concentrations in blood plasma and cerebrospinal fluid (CSF) obtained from subjects with neurodegenerative and inflammatory diseases of the central nervous system (CNS) as well as in a control group. MATERIAL AND METHODS: Using an enzyme-linked immunosorbent assay (ELISA), we measured the actinfree Gc-globulin concentrations in blood plasma and CSF obtained from subjects diagnosed with Alzheimer's disease (AD) (n = 20), amyotrophic lateral sclerosis (ALS) (n = 12), multiple sclerosis (MS) (n = 42), tick-borne encephalitis (TBE) (n = 12), and from a control group (n = 20)...
June 15, 2018: Advances in Clinical and Experimental Medicine: Official Organ Wroclaw Medical University
https://www.readbyqxmd.com/read/29905410/ivabradine-inhibits-carbachol-induced-contractions-of-isolated-rat-urinary-bladder
#11
Hasan Riza Aydin, Hasan Turgut, Aysegul Kurt, Ramazan Sahan, Omer Faruk Kalkan, Huseyin Eren, Ahmet Ayar
BACKGROUND: Overactive bladder (OAB), a symptom syndrome defined as urgency, is a common clinical condition, which sometimes cannot be satisfactorily treated with current medications in every subject; therefore, alternatives are needed. OBJECTIVES: The aim of this in vitro study was to investigate the effects of ivabradine, a selective pacemaker If current inhibitor, on agonist-induced isometric contractions of the bladder smooth muscles. MATERIAL AND METHODS: Urinary bladder strips were isolated from adult male Wistar rats and suspended in a tissue bath containing physiological solution...
June 14, 2018: Advances in Clinical and Experimental Medicine: Official Organ Wroclaw Medical University
https://www.readbyqxmd.com/read/29905409/l-fabp-and-il-6-as-markers-of-chronic-kidney-damage-in-children-after-hemolytic-uremic-syndrome
#12
Katarzyna Lipiec, Piotr Adamczyk, Elżbieta Świętochowska, Katarzyna Ziora, Maria Szczepańska
BACKGROUND: Hemolytic-uremic syndrome (HUS) is a form of thrombotic microangiopathy, in the course of which some patients may develop chronic kidney disease (CKD). From a clinical point of view, it is important to search for markers that allow for early identification of patients at risk of a poor prognosis. OBJECTIVES: The study evaluated the serum and urine levels of liver-type fatty acid binding protein (L-FABP) and interleukin 6 (IL-6). MATERIAL AND METHODS: The study was conducted in 29 children with a history of HUS...
June 13, 2018: Advances in Clinical and Experimental Medicine: Official Organ Wroclaw Medical University
https://www.readbyqxmd.com/read/29905408/ginkgolide-b-exerts-anti-inflammatory-and-chondroprotective-activity-in-lps-induced-chondrocytes
#13
Hejia Hu, Yan Li, Zengfeng Xin, Xiangfeng Zhanga
BACKGROUND: Osteoarthritis (OA) is one of degenerative and chronic diseases of articular joints. Articular cartilage is an avascular tissue, and its primary cellular component is chondrocytes. The main characteristic of OA is non-classic inflammation and cartilage degeneration. Ginkgolide B (GB) is a component of Ginkgo biloba which has diverse bioactivities. OBJECTIVES: The present study uses an in vitro experimental model to detect the underlying anti-inflammatory and chondroprotective effects of GB and provides a new way for future clinical therapy of OA...
June 13, 2018: Advances in Clinical and Experimental Medicine: Official Organ Wroclaw Medical University
https://www.readbyqxmd.com/read/29893517/relationship-between-the-expression-of-cd25-and-cd69-on-the-surface-of-lymphocytes-t-and-b-from-peripheral-blood-and-bone-marrow-of-patients-with-chronic-lymphocytic-leukemia-and-established-prognostic-factors-of-this-disease
#14
Ewelina Grywalska, Małgorzata Bartkowiak-Emeryk, Marcin Pasiarski, Karolina Olszewska-Bożek, Michał Mielnik, Martyna Podgajna, Monika Pieczykolan, Anna Hymos, Elżbieta Fitas, Agata Surdacka, Stanisław Góźdź, Jacek Roliński
BACKGROUND: Chronic lymphocytic leukemia (CLL) is a condition characterized by the accumulation of morphologically mature monoclonal lymphocytes B with the CD19+/CD5+/CD23+ phenotype in lymphoid tissue, peripheral blood and bone marrow. The clinical course of patients with CLL is heterogeneous, ranging from indolent to aggressive. The role of lymphocyte activation in the natural history of CLL is still a matter of discussion. OBJECTIVES: The aim of this study was to determine the percentages and absolute numbers of lymphocytes B and T in peripheral blood and bone marrow of CLL patients...
June 12, 2018: Advances in Clinical and Experimental Medicine: Official Organ Wroclaw Medical University
https://www.readbyqxmd.com/read/29893516/stool-patterns-and-symptoms-of-disordered-anorectal-function-in-patients-with-inflammatory-bowel-diseases
#15
Paweł W Petryszyn, Leszek Paradowski
BACKGROUND: Crohn's disease (CD) and ulcerative colitis (UC) typically clinically manifest with symptoms like chronic diarrhea, cramps, abdominal pain, and rectal bleeding. However, symptoms of abnormal anorectal function seem to be of equal importance, regardless of the presence or absence of perianal disease. OBJECTIVES: The aim of this study was to assess stool patterns and the prevalence of symptoms of disordered anorectal function, particularly urgency and fecal incontinence, and their severity in patients with inflammatory bowel diseases (IBDs)...
June 12, 2018: Advances in Clinical and Experimental Medicine: Official Organ Wroclaw Medical University
https://www.readbyqxmd.com/read/29893515/cxcl9-cxcl10-cxcl11-and-their-receptor-cxcr3-in-neuroinflammation-and-neurodegeneration
#16
REVIEW
Olga M Koper, Joanna Kamińska, Karol Sawicki, Halina Kemona
The aim of this review is to present data from the available literature concerning CXCL9, CXCL10 and CXCL11, as well as their receptor 3 (CXCR3) in selected diseases of the central nervous system (CNS), such as tickborne encephalitis (TBE), neuroborreliosis (NB), Alzheimer's disease (AD), and multiple sclerosis (MS). CXCL9, CXCL10, and CXCL11 lack glutamic acid-leucine-arginine (ELR), and are unique, because they are more closely related to each other than to any other chemokine. The aforementioned chemokines are especially involved in Th1-type response and in various diseases, as their expression correlates with the tissue infiltration of T cells...
June 8, 2018: Advances in Clinical and Experimental Medicine: Official Organ Wroclaw Medical University
https://www.readbyqxmd.com/read/29893514/performance-evaluation-of-hbsag-by-lumipulse-hbsag-hq-the-agreement-with-hbsag-by-architect-hbsag-qt-and-the-effectiveness-in-predicting-liver-tissue-pathological-states-of-chronic-hepatitis-b-patients
#17
Zhanqing Zhang, Rongrong Ding, Wei Lu, Zhiqiang Yang, Yanbing Wang, Xinlan Zhou, Dan Huang, Xiufen Li, Yanling Feng
BACKGROUND: A novel high-sensitivity HBsAg quantification assay, Lumipulse HBsAg-HQ, was developed. However, its performance in practical application has not yet been adequately investigated. OBJECTIVES: The aim of the study was to evaluate the agreement of serum HBsAg by Lumipulse HBsAg-HQ (HBsAg-HQ) with HBsAg by Architect HBsAg-QT (HBsAg-QT) and comparatively investigate the efficacy of serum HBsAg-HQ and HBsAg-QT in predicting the liver tissue pathological states of chronic hepatitis B (CHB) patients...
June 8, 2018: Advances in Clinical and Experimental Medicine: Official Organ Wroclaw Medical University
https://www.readbyqxmd.com/read/29893513/pik3r1-gene-polymorphisms-are-associated-with-type-2-diabetes-and-related-features-in-the-turkish-population
#18
Abdullah Hakan Karadoğan, Hilal Arikoglu, Fatma Göktürk, Funda İşçioğlu, Süleyman Hilmi İpekçi
BACKGROUND: The phosphatidylinositol 3-kinase p85 alpha regulatory subunit 1 gene (PIK3R1) encodes the PIK3R1 protein, which plays a direct role in insulin signaling. PIK3R1 (p85 regulatory subunit) connects firmly with the p110 catalytic subunit, and together these proteins form the phosphatidylinositol 3-kinase (PI3K) protein. PI3K is a key protein in the Akt signaling pathway, which regulates cell survival, growth, differentiation, glucose trafficking, and utilization. Defects in the insulin signaling cascade play an important role in the development of insulin resistance, which shares a common genetic basis for metabolic diseases such as type 2 diabetes (T2D), obesity and cardiovascular diseases...
June 8, 2018: Advances in Clinical and Experimental Medicine: Official Organ Wroclaw Medical University
https://www.readbyqxmd.com/read/29893512/the-relationship-between-event-related-potentials-stress-perception-and-personality-type-in-patients-with-multiple-sclerosis-without-cognitive-impairment-a-pilot-study
#19
Marta Waliszewska-Prosół, Marta Nowakowska-Kotas, Roman Kotas, Tomasz Bańkowski, Anna Pokryszko-Dragan, Ryszard Podemski
BACKGROUND: The clinical course of multiple sclerosis (MS) can vary significantly among patients and is affected by exogenous and endogenous factors. Among these, stress and personality type have been gaining more attention. OBJECTIVES: The aim of this study was to investigate the parameters of event-related potentials (ERPs) with regards to stress perception and personality type, as well as cognitive performance in MS patients. MATERIAL AND METHODS: The study group consisted of 30 MS patients and 26 healthy controls...
June 8, 2018: Advances in Clinical and Experimental Medicine: Official Organ Wroclaw Medical University
https://www.readbyqxmd.com/read/29877639/high-prevalence-of-antinuclear-antibodies-in-patients-following-venous-thromboembolism
#20
Joanna Natorska, Magdalena Celińska-Löwenhoff, Anetta I Undas
BACKGROUND: Growing evidence suggests that activation of blood coagulation exerts protective functions during inflammation. However, it has been hypothesized that dysregulated immunothrombosis may lead to venous thromboembolism (VTE). Antinuclear antibodies (ANAs) are considered to promote the thrombotic tendency but there have been no reports on the association between ANAs and VTE. OBJECTIVES: The objective of this study was to investigate if the presence of ANAs is associated with VTE...
June 7, 2018: Advances in Clinical and Experimental Medicine: Official Organ Wroclaw Medical University
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