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Cancer Biology & Therapy

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https://www.readbyqxmd.com/read/28095111/increased-numb-protein-expression-predicts-poor-clinical-outcomes-in-esophageal-squamous-cell-carcinoma-patients
#1
Zhenguo Liu, Canqiao Luo, Weixiong Yang, Kefeng Wang, Chuang Hu, Jianyong Zou, Hua Zhu, Liwu Fu, Jing Nie, Chao Cheng
Numb is a protein whose asymmetric segregation during cell division determines cell fate and has numerous functions relevant to multiple fields of study, including developmental neurobiology and cancer biology. Little is known about the role of Numb in esophageal squamous cell carcinoma (ESCC), the predominant histological esophageal carcinoma in Asian populations. In this study, we focused on the expression and biological functions of Numb in the context of ESCC. From analysis of tissue microarrays with 212 patients, it was found that Numb was significantly upregulated in ESCC tissues compared to corresponding non-cancerous tissues...
January 17, 2017: Cancer Biology & Therapy
https://www.readbyqxmd.com/read/28075192/loss-of-monocyte-chemoattractant-protein-1-expression-delays-mammary-tumorigenesis-and-reduces-localized-inflammation-in-the-c3-1-sv40tag-triple-negative-breast-cancer-model
#2
Taryn L Cranford, Kandy T Velázquez, Reilly T Enos, Jackie E Bader, Meredith S Carson, Ioulia Chatzistamou, Mitzi Nagarkatti, E Angela Murphy
Monocyte chemoattractant protein 1 (MCP-1) has been implicated as a major modulator in the progression of mammary tumorigenesis, largely due to its ability to recruit macrophages to the tumor microenvironment. Macrophages are key mediators in the connection between inflammation and cancer progression and have been shown to play an important role in tumorigenesis. Thus, MCP-1 may be a potential therapeutic target in inflammatory and difficult-to-treat cancers such as triple negative breast cancer (TNBC). We examined the effect of MCP-1 depletion on mammary tumorigenesis in a model of TNBC...
January 11, 2017: Cancer Biology & Therapy
https://www.readbyqxmd.com/read/28071969/curcumin-induces-apoptosis-in-human-leukemic-cell-lines-through-an-ifit2-dependent-pathway
#3
Yonglu Zhang, Yunyuan Kong, Shuyuan Liu, Lingbing Zeng, Lagen Wan, Zhanglin Zhang
Curcumin, the primary bioactive component isolated from turmeric, has been shown to possess variety of biological functions including anti-cancer activity. However, molecular mechanisms different cancer cells are various. In the present study, we demonstrated that curcumin induced G2/M cell cycle arrest and apoptosis by increasing the expression levels of cleaved caspase-3, cleaved PARP and decreasing the expression of BCL-2 in U937 human leukemic cells but not in K562 cells. We found some interferon induced genes, especially interferon-induced protein with tetratricopeptide repeats 2 (IFIT2), were significantly up-regulated when treated with curcumin in U937 cells by gene expression chip array, and further confirmed that the expression of IFIT2 was obviously higher in U937 than that in K562 cells by Western blot assay...
January 10, 2017: Cancer Biology & Therapy
https://www.readbyqxmd.com/read/28059588/corrigendum
#4
(no author information available yet)
No abstract text is available yet for this article.
January 6, 2017: Cancer Biology & Therapy
https://www.readbyqxmd.com/read/28055304/synergistic-effect-of-cytokine-induced-killer-cell-with-valproate-inhibits-growth-of-hepatocellular-carcinoma-cell-in-a-mouse-model
#5
Dong Hyeon Lee, Joon Yeul Nam, Young Chang, Hyeki Cho, Seong Hee Kang, Young Youn Cho, EunJu Cho, Jeong-Hoon Lee, Su Jong Yu, Yoon Jun Kim, Jung-Hwan Yoon
OBJECTIVE: Long-term prognosis of hepatocellular carcinoma (HCC) remains poor owing to the lack of treatment options for advanced HCC. Cytokine-induced killer (CIK) cells are ex vivo expanded T lymphocytes expressing both NK- and T-cell markers. CIK cell therapy alone is insufficient for treating advanced HCC. Thus, this study aimed to determine whether treatment with CIK cells combined with valproic acid (VPA) could provide a synergistic effect to inhibit tumor growth in a mouse model of HCC...
January 5, 2017: Cancer Biology & Therapy
https://www.readbyqxmd.com/read/28055291/metuzumab-enhanced-chemosensitivity-and-apoptosis-in-non-small-cell-lung-carcinoma
#6
Fei Feng, Bin Wang, Xiuxuan Sun, Yumeng Zhu, Hao Tang, Gang Nan, Lijuan Wang, Bo Wu, Muren Huhe, Shuangshuang Liu, Tengyue Diao, Rong Hou, Yang Zhang, Zheng Zhang
Targeted therapeutics is used as an alternative treatment for non-small cell lung cancer (NSCLC); however, treatment effect is far from being satisfactory, and therefore identification of new targets is needed. We have previously shown that metuzumab inhibit tumor growth in vivo. The present study was performed to investigate the anti-tumor efficacy of metuzumab combined with gemcitabine and cisplatin (GP), paclitaxel and cisplatin (TP) or navelbine and cisplatin (NP) regimens in multiple NSCLC cell lines. Our results demonstrate that, in comparison to single agent metuzumab or GP treated cells, metuzumab combined with GP display inhibitory effects on tumor growth...
January 5, 2017: Cancer Biology & Therapy
https://www.readbyqxmd.com/read/28045618/tumor-markers-for-early-diagnosis-for-brain-metastasis-of-hepatocellular-carcinoma-a-case-series-and-literature-review-for-effective-loco-regional-treatment
#7
Kenya Kamimura, Yuji Kobayashi, Yoshifumi Takahashi, Hiroyuki Abe, Daisuke Kumaki, Takeshi Yokoo, Hiroteru Kamimura, Norihiro Sakai, Akira Sakamaki, Satoshi Abe, Masaaki Takamura, Hirokazu Kawai, Satoshi Yamagiwa, Shuji Terai
Intrahepatic lesions of hepatocellular carcinoma (HCC) have been controlled by significant advances in treatment using loco-regional therapies, including, surgery, ablative therapy, catheter-based chemotherapy, and embolization. Consequently, the number of patients with extrahepatic metastatic lesions has increased. Their prognosis remains poor with approximately <1 year of survival from the time of diagnosis. A molecularly targeted drug, sorafenib, have been used to treat extrahepatic lesions and shown the prolonged survival time...
January 3, 2017: Cancer Biology & Therapy
https://www.readbyqxmd.com/read/28045589/dietary-selenium-protects-adiponectin-knockout-mice-against-chronic-inflammation-induced-colon-cancer
#8
Arpit Saxena, Raja Fayad, Kamaljeet Kaur, Samantha Truman, Julian Greer, James A Carson, Anindya Chanda
Selenium (Se) is an essential dietary micronutrient that has been examined for protection against different types of cancers including colon cancer. Despite an established inverse association between Se and chronic inflammation induced colon cancer (CICC), the mechanistic understanding of Se's protective effects requires additional in-vivo studies using preclinical animal models of CICC. Adiponectin (APN) is an adipocytokine that is protective against CICC as well. However, its role in the anti-mutagenic effects of the Se-diet remains unknown...
January 3, 2017: Cancer Biology & Therapy
https://www.readbyqxmd.com/read/28045576/combination-therapy-with-l-arginine-and-%C3%AE-pd-l1-antibody-boosts-immune-response-against-osteosarcoma-in-immunocompetent-mice
#9
Xiaojun He, Haiqing Lin, Li Yuan, Binghao Li
L-arginine supplementation was recently proved to promote the function of immune cells, especially T-cells, by facilitating T-cell proliferation, differentiation and survival in vivo. Cytotoxic CD8(+) plays a crucial role in modulating anti-cancer response mediated by the immune system, but was restricted by exhaustion. Thus, we hypothesized that L-arginine, in combination with α-PD-L1 antibody, may provide a favored environment for T-cell response against osteosarcoma. Immunocompetent BALB/c mouse models bearing orthotopic and metastatic osteosarcoma were established to validate this conjecture...
January 3, 2017: Cancer Biology & Therapy
https://www.readbyqxmd.com/read/28045569/direct-measurement-of-hypoxia-in-a-xenograft-multiple-myeloma-model-by-optical-resolution-photoacoustic-microscopy
#10
Toru Imai, Barbara Muz, Cheng-Hung Yeh, Junjie Yao, Ruiying Zhang, Abdel Kareem Azab, Lihong Wang
Using photoacoustic microscopy (PAM), we evaluated non-invasively oxygenation and vascularization in vivo due to multiple myeloma (MM) progression. Mice injected with MM1s-GFP cells were monitored with a fluorescence microscope for tumor progression. In vivo PAM of the cerebral bone marrow quantified the total oxygen saturation (sO2). At 28 days after the MM cell injection, the total sO2 had decreased by half in the developing tumor regions, while in the non-tumor regions it had decreased by 20% compared to the value at one day post MM injection...
January 3, 2017: Cancer Biology & Therapy
https://www.readbyqxmd.com/read/27981892/phenethyl-isothiocyanate-suppresses-the-metastasis-of-ovarian-cancer-associated-with-the-inhibition-of-crm1-mediated-nuclear-export-and-mtor-stat3-pathway
#11
Wen Yu Shao, Yong Liang Yang, Huan Yan, Qian Huang, Kai Jiang Liu, Shu Zhang
Epithelial ovarian cancer is prone to metastasizing at an early stage, but their mechanisms remain unclear. CRM1 is an important nuclear exportin and inhibitors targeting CRM1 has been explored as an anti-cancer strategy. In previous study, we observed that PEITC could combine with the hydrophobic pocket of CRM1. In this study, we focused on the effects of PEITC on EOC and its mechanisms. Results showed that IC50 values of PEITC on SKOV3 and HO8910 cell line were 42.14 μM and 37.29 μM, respectively. PEITC inhibits the migration and invasion of SKOV3 and HO8910 cells in vitro...
December 16, 2016: Cancer Biology & Therapy
https://www.readbyqxmd.com/read/27922336/abscopal-regression-following-sabr-for-non-small-cell-lung-cancer-a-case-report
#12
Yang Cong, Ge Shen, Shikai Wu, Ruimin Hao
Out-of-field tumor response, which is also called abscopal effect, bystander effect, or non-target effect, can be regarded as localized irradiation induced systemic antitumorigenic effects, indicating shrinkage of a tumor distant from the irradiated site. Although abscopal effect has been documented in several tumor types, it is a very rare phenomenon which is clinically reported in non-small-cell-lung carcinoma (NSCLC). Herein, we present a rare case of patient with NSCLC with 2 lesions in the upper lobe of left lung who, after receiving stereotactic ablative radiation therapy (SABR) to one of the tumors, had an apparent spontaneous regression of the other mass in the lung, suggestive of a radiation-induced abscopal effect...
December 6, 2016: Cancer Biology & Therapy
https://www.readbyqxmd.com/read/27905830/isolated-cardiac-peripheral-primitive-neuroectodermal-tumor-a-case-report
#13
Chengming Fan, Demiao Kong, Changming Tan, Jinfu Yang
BACKGROUND: Peripheral primitive neuroectodermal tumor isolated in the heart, presenting as a primary cardiac tumor is considered as extremely rare. METHODS: We present a 53-year-old Chinese female with a cardiac tumor which was discovered by CT. RESULTS: A hypo-intense tumorous mass was shown extending from the left ventricle by Cardiac CT, and fused FDG positron emission tomography demonstrated no other abnormal FDG active lesions in the body...
December 1, 2016: Cancer Biology & Therapy
https://www.readbyqxmd.com/read/27905824/improved-survival-and-complete-response-rates-in-patients-with-advanced-melanoma-treated-with-concurrent-ipilimumab-and-radiotherapy-versus-ipilimumab-alone
#14
Kristian M Koller, Heath B Mackley, Jason Liu, Henry Wagner, Giampaolo Talamo, Todd D Schell, Colette Pameijer, Rogerio I Neves, Bryan Anderson, Kathleen M Kokolus, Carol A Mallon, Joseph J Drabick
There is a growing body of evidence supporting the synergistic roles of radiotherapy and immunotherapy in the treatment of malignancy. Published case studies of the abscopal effect have been reported with the use of ipilimumab and radiotherapy in metastatic melanoma, but evidence supporting the routine use of this combination of therapy is limited. We conducted a retrospective analysis to evaluate patients treated with ipilimumab for advanced melanoma at a single institution from May 2011 to June 2015. Patients were grouped into those who had received concurrent radiotherapy while on ipilimumab (Ipi-RT), and those who did not...
December 1, 2016: Cancer Biology & Therapy
https://www.readbyqxmd.com/read/27830973/trim21-is-a-novel-regulator-of-par-4-in-colon-and-pancreatic-cancer-cells
#15
Jeffrey Q Nguyen, Rosalyn B Irby
The prostate apoptosis response protein 4 (Par-4) is a tumor-suppressor that has been shown to induce cancer-cell selective apoptosis in a variety of cancers. The regulation of Par-4 expression and activity is a relatively understudied area, and identifying novel regulators of Par-4 may serve as novel therapeutic targets. To identify novel regulators of Par-4, a co-immunoprecipitation was performed in colon cancer cells, and co-precipitated proteins were identified by mass-spectometry. TRIM21 was identified as a novel interacting partner of Par-4, and further shown to interact with Par-4 endogenously and through its PRY-SPRY domain...
November 10, 2016: Cancer Biology & Therapy
https://www.readbyqxmd.com/read/27819521/microrna-326-sensitizes-human-glioblastoma-cells-to-curcumin-via-the-shh-gli1-signaling-pathway
#16
Shi Yin, Wenzhong Du, Feng Wang, Bo Han, Yuqiong Cui, Dongbo Yang, Hui Chen, Daming Liu, Xing Liu, Chuanlu Jiang
Glioblastoma multiforme is the most malignant and common brain tumor in adults and is characterized by poor survival and high resistance to chemotherapy and radiotherapy. Among the new chemotherapy drugs, curcumin, a popular dietary supplement, has proven to have a potent anticancer effect on a variety of cancer cell types; however, it remains difficult to achieve a satisfactory therapeutic effect with curcumin using the traditional single-drug treatment. In this study, we found that expression of miR-326, a tumor suppressor microRNA in various tumor types, resulted in a marked increase of curcumin-induced cytotoxicity and apoptosis and a decrease of proliferation and migration in glioma cells...
November 7, 2016: Cancer Biology & Therapy
https://www.readbyqxmd.com/read/27791463/blocking-notch-pathway-can-enhance-the-effect-of-egfr-inhibitor-through-targeting-cd133-endometrial-cancer-cells
#17
Chao Shang, Bin Lang, Li-Rong Meng
ABSTACT Although the molecular therapeutics targeting key biomarkers such as epithelial growth factor receptor (EGFR), PI3K/AKT/mTOR, and vascular endothelial growth factor (VEGF) shows some success in clinical trials, some internally existing challenges in endothelial cancer biology hinder the drug effects. One of the major challenges stems from cancer stem cell-derived drug resistance. CD133 positive cells are well believed as cancer stem cells (CSC) in endometrial cancers and NOTCH pathway plays a critical role in retaining CD133+ cells by promoting CSC self-renewal and chemoresistance...
October 28, 2016: Cancer Biology & Therapy
https://www.readbyqxmd.com/read/27786596/identification-of-tdp-43-as-an-oncogene-in-melanoma-and-its-function-during-melanoma-pathogenesis
#18
Qinghai Zeng, Ke Cao, Rui Liu, Jinhua Huang, Kun Xia, Jintian Tang, Xiang Chen, Ming Zhou, Huiqing Xie, Jianda Zhou
BACKGROUND: Although recent studies have revealed TAR (trans-activating response region) DNA binding protein (TDP-43) as a potential therapeutic target for cancers, its role and clinical association with melanoma have not been explored. OBJECTIVE: To identify the role and function of TDP-43 during melanoma pathogenesis. METHODS: Firstly, the relationship between TDP-43 expression and patient survival was explored. Then TDP-43 expression level in melanoma tissue and different melanoma cell lines was measured...
October 27, 2016: Cancer Biology & Therapy
https://www.readbyqxmd.com/read/27786591/suppression-of-b-raf-v600e-melanoma-cell-survival-by-targeting-mitochondria-using-triphenyl-phosphonium-conjugated-nitroxide-or-ubiquinone
#19
Seung-Keun Hong, Dmytro Starenki, Pui-Kei Wu, Jong-In Park
Most BRAF-mutated melanomas initially responsive to the FDA-approved inhibitors preferentially targeting B-Raf mutated in Val600 residue eventually relapse, requiring additional therapeutic modalities. Recent studies report the significance of metabolic reprograming in mitochondria for maintenance of BRAF-mutated melanomas and for development of their drug resistance to B-Raf inhibitors, providing a rationale for targeting mitochondria as a potential therapeutic strategy for melanoma. We therefore determined whether mitochondria-targeted metabolism-interfering agents can effectively suppress human B-Raf(V600E) melanoma cell lines and their dabrafenib/PLX4032-resistant progenies using mitochondria-targeted carboxy-proxyl (Mito-CP) and ubiquinone (Mito-Q)...
October 27, 2016: Cancer Biology & Therapy
https://www.readbyqxmd.com/read/27834580/nkg2d-ligand-expression-in-pediatric-brain-tumors
#20
Kristen Haberthur, Kathryn Brennan, Virginia Hoglund, Stephanie Balcaitis, Harrison Chinn, Amira Davis, Shannon Kreuser, Conrad Winter, Sarah E S Leary, Gail H Deutsch, Richard G Ellenbogen, Courtney A Crane
Adult brain tumors establish an immunosuppressive tumor microenvironment as a modality of immune escape, with several immunotherapies designed to overcome this barrier. However, the relationship between tumor cells and immune cells in pediatric brain tumor patients is not as well-defined. In this study, we sought to determine whether the model of immune escape observed in adult brain tumors is reflected in patients with pediatric brain tumors by evaluating NKG2D ligand expression on tissue microarrays created from patients with a variety of childhood brain tumor diagnoses, and infiltration of Natural Killer and myeloid cells...
December 2016: Cancer Biology & Therapy
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