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Cell Cycle

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https://www.readbyqxmd.com/read/28324668/-fem1-nism-controls-slbp-stability-during-cell-cycle
#1
Jinfang Zhang, Jing Liu, Wenyi Wei
No abstract text is available yet for this article.
March 21, 2017: Cell Cycle
https://www.readbyqxmd.com/read/28324667/gtpase-activating-protein-elmod2-is-essential-for-meiotic-progression-in-mouse-oocytes
#2
Chun-Xiang Zhou, Li-Ya Shi, Rui-Chao Li, Ya-Hong Liu, Bo-Qun Xu, Jin-Wei Liu, Bo Yuan, Zhi-Xia Yang, Xiao-Yan Ying, Dong Zhang
Meiotic failure in oocytes is the major determinant of human zygote-originated reproductive diseases, the successful accomplishment of meiosis largely relay on the normal functions of many female fertility factors. Elmod2 is a member of the Elmod family with the strongest GAP (GTPase-activating protein) activity; although it was identified as a possible maternal protein, its actual physiologic role in mammalian oocytes has not been elucidated. Herein we reported that among Elmod family proteins, Elmod2 is the most abundant in mouse oocytes, and that inhibition of Elmod2 by specific siRNA caused severe meiotic delay and abnormal chromosomal segregation during anaphase...
March 21, 2017: Cell Cycle
https://www.readbyqxmd.com/read/28319441/calorie-restriction-breaks-an-epigenetic-barrier-to-longevity
#3
Diego Molina-Serrano, Antonis Kirmizis
No abstract text is available yet for this article.
March 20, 2017: Cell Cycle
https://www.readbyqxmd.com/read/28319439/loss-of-a-primary-cilium-in-pdac
#4
Tetsuo Kobayashi, Hiroshi Itoh
No abstract text is available yet for this article.
March 20, 2017: Cell Cycle
https://www.readbyqxmd.com/read/28319437/translation-regulator-ballet-in-meiotic-spindle
#5
Patrick Cormier
No abstract text is available yet for this article.
March 20, 2017: Cell Cycle
https://www.readbyqxmd.com/read/28319435/spar-a-lncrna-encoded-mtorc1-inhibitor
#6
Akinobu Matsumoto, John G Clohessy, Pandolfi Pier Paolo
No abstract text is available yet for this article.
March 20, 2017: Cell Cycle
https://www.readbyqxmd.com/read/28318386/towards-precision-oncology-in-ret-aberrant-cancers
#7
Vivek Subbiah, Jason Roszik
No abstract text is available yet for this article.
March 20, 2017: Cell Cycle
https://www.readbyqxmd.com/read/28318385/arsenic-induced-sumoylation-of-mus81-is-involved-in-regulating-genomic-stability
#8
Liyan Hu, Feikun Yang, Lou Lu, Wei Dai
Chronic environmental exposure to metal toxicants such as chromium and arsenic is closely related to the development of several types of common cancers. Genetic and epigenetic studies in the past decade reveal that post-translational modifications of histones play a role in metal carcinogenesis. However, exact molecular mechanisms of metal carcinogenesis remain to be elucidated. In this study we found that As2O3, an environmental metal toxicant, up-regulated overall modifications of many cellular proteins by SUMO2/3...
March 20, 2017: Cell Cycle
https://www.readbyqxmd.com/read/28318374/identification-and-characterization-of-the-bmcyclin-l1-bmcdk11a-b-complex-in-relation-to-cell-cycle-regulation
#9
Tai-Hang Liu, Yun-Fei Wu, Xiao-Long Dong, Cai-Xia Pan, Guo-Yu Du, Ji-Gui Yang, Wei Wang, Xi-Yan Bao, Peng Chen, Min-Hui Pan, Cheng Lu
Cyclin proteins are the key regulatory and activity partner of cyclin-dependent kinases (CDKs), which play pivotal regulatory roles in cell cycle progression. In the present study, we identified a Cyclin L1 and two CDK11 two CDK11 splice variants, CDK11A and CDK11B, from silkworm, Bombyx mori. We determined that both Cyclin L1 and CDK11A/B are nuclear proteins, and further investigations were conducted to elucidate their spatiofunctional features. Cyclin L1 forms a complex with CDK11A/B and were co-localized to the nucleus...
March 20, 2017: Cell Cycle
https://www.readbyqxmd.com/read/28318368/the-wayward-methyl-group-and-the-cascade-to-cancer
#10
Robert M Hoffman
We propose here a hypothesis of the cause of cancer that brings together fundamental changes in methyl-group metabolism resulting in global DNA hypomethylation which destabilizes the genome leading to aneuploid karyotypes which evolve and stabilize into autonomous cancer. Experimental support for this hypothesis is that methioine dependence is a general metabolic defect in caner. Methionine dependence is due to excess use of methionene for aberrant transmethylation reactions that apparently divert methyl groups from DNA...
March 20, 2017: Cell Cycle
https://www.readbyqxmd.com/read/28301263/a-stitch-in-time-and-cdk9
#11
W Douglas Cress
No abstract text is available yet for this article.
March 16, 2017: Cell Cycle
https://www.readbyqxmd.com/read/28296622/a-cell-based-screening-approach-for-identifying-protein-degradation-regulators
#12
Scott Simanski, Marie E Maloof, Trey K Sato, Valerie Cavett, Jennifer Caldwell Busby, Nagi G Ayad
Cellular transitions are achieved by the concerted actions of regulated degradation pathways. In the case of the cell cycle, ubiquitin mediated degradation ensures unidirectional transition from one phase to another. For instance, turnover of the cell cycle regulator cyclin B1 occurs after metaphase to induce mitotic exit. To better understand pathways controlling cyclin B1 turnover, the N terminal domain of cyclin B1 was fused to luciferase to generate an N-cyclin B1-luciferase protein that can be used as a reporter for protein turnover...
March 15, 2017: Cell Cycle
https://www.readbyqxmd.com/read/28296571/efficient-generation-of-functional-schwann-cells-from-adipose-derived-stem-cells-in-defined-conditions
#13
Songtao Xie, Fan Lu, Juntao Han, Ke Tao, Hongtao Wang, Alfred Simental, Dahai Hu, Hao Yang
Schwann cells (SCs) are hitherto regarded as the most promising candidates for viable cell-based therapy to peripheral nervous system (PNS) injuries or degenerative diseases. However, the extreme drawbacks of transplanting autologous SCs for clinical applications still represent a significant bottleneck in neural regenerative medicine, mainly owing to the need of sacrificing a functional nerve to generate autologous SCs and the nature of slow expansion of the SCs. Thus, it is of great importance to establish an alternative cell system for the generation of sufficient SCs...
March 15, 2017: Cell Cycle
https://www.readbyqxmd.com/read/28296564/azd1775-induces-toxicity-through-double-stranded-dna-breaks-independently-of-chemotherapeutic-agents-in-p53-mutated-colorectal-cancer-cells
#14
Peter John Webster, Anna Tiffany Littlejohns, Hannah Jane Gaunt, K Raj Prasad, David John Beech, Dermot Anthony Burke
AZD1775 is a small molecule WEE1 inhibitor used in combination with DNA-damaging agents to cause premature mitosis and cell death in p53-mutated cancer cells. Here we sought to determine the mechanism of action of AZD1775 in combination with chemotherapeutic agents in light of recent findings that AZD1775 can cause double-stranded DNA (DS-DNA) breaks. AZD1775 significantly improved the cytotoxicity of 5-FU in a p53-mutated colorectal cancer cell line (HT29 cells), decreasing the IC50 from 9.3 μM to 3.5 μM...
March 15, 2017: Cell Cycle
https://www.readbyqxmd.com/read/28296561/tyr-less-kinase-signalling-during-mitosis
#15
Sabine Elowe
Tyrosine phosphorylation is rare, representing only about 0.5% of phosphorylations in the cell under basal conditions. While mitogenic tyrosine kinase signalling has been extensively explored, the role of phosphotyrosine signaling across the cell cycle and in particular during mitosis is poorly understood. Two recent, independent studies tackled this question from different angles to reveal exciting new insights into the role of this modification during cell division. Caron et al. (1) exploited mitotic phosphoproteomics datasets to determine the extent of mitotic tyrosine phosphorylation, and St-Denis et al...
March 15, 2017: Cell Cycle
https://www.readbyqxmd.com/read/28296559/the-irony-of-highly-effective-bacterial-therapy-of-a-patient-derived-orthotopic-xenograft-pdox-model-of-ewing-s-sarcoma-which-was-blocked-by-ewing-himself-80%C3%A2-years-ago
#16
Takashi Murakami, Tasuku Kiyuna, Kei Kawaguchi, Kentaro Igarashi, Arun S Singh, Yukihiko Hiroshima, Yong Zhang, Ming Zhao, Kentaro Miyake, Scott D Nelson, Sarah M Dry, Yunfeng Li, Jonathan C DeLong, Thinzar M Lwin, Takashi Chishima, Kuniya Tanaka, Michael Bouvet, Itaru Endo, Fritz C Eilber, Robert M Hoffman
William B. Coley developed bacterial therapy of cancer more than 100 years ago and had clinical success. James Ewing, a very famous cancer pathologist for whom the Ewing sarcoma is named, was Coley's boss at Memorial Hospital in New York and terminated Coley's bacterial therapy of cancer. A tumor from a patient with soft-tissue Ewing's sarcoma, who failed doxorubicin (DOX) therapy, was previously implanted in nude mice to establish a patient-derived orthotopic xenograft (PDOX) model. In the present study, the Ewing's sarcoma PDOX was treated with tumor-targeting S...
March 15, 2017: Cell Cycle
https://www.readbyqxmd.com/read/28296554/a-novel-p53-cdc7-link-induced-by-genotoxic-stress
#17
Hisao Masai
No abstract text is available yet for this article.
March 15, 2017: Cell Cycle
https://www.readbyqxmd.com/read/28296539/high-salt-induced-activation-and-expression-of-inflammatory-cytokines-in-cultured-astrocytes
#18
Zhezhi Deng, Yuge Wang, Li Zhou, Yilong Shan, Sha Tan, Wei Cai, Siyuan Liao, Lisheng Peng, Zhengqi Lu
Salt (sodium chloride, NaCl) accumulation in the brain is associated with various diseases of central nervous system (CNS). Activation of astrocytes is an important manifestation of pathophysiological processes in the CNS. However, the direct impact of high salt (HS) environment on astrocytes is unclear. In the current study, we found that high salt treatment can induce activation of astrocytes both in vivo and in vitro, manifested as morphological alteration coupled with increased expression of glial fibrillary acidic protein (GFAP)...
March 15, 2017: Cell Cycle
https://www.readbyqxmd.com/read/28287892/landscaping-a-chromatin-response-to-mek-inhibition
#19
Jon S Zawistowski, Daniel R Goulet, Gary L Johnson
No abstract text is available yet for this article.
March 13, 2017: Cell Cycle
https://www.readbyqxmd.com/read/28287365/the-gaps-gefs-gdis-and%C3%A2-now-gems-new-kids-on-the-heterotrimeric-g-protein-signaling-block
#20
Pradipta Ghosh, Padmini Rangamani, Irina Kufareva
The canonical process of activation of heterotrimeric G proteins by G protein coupled receptors (GPCRs) is well studied. Recently, a rapidly emerging paradigm has revealed the existence of a new, non-canonical set of cytosolic G protein modulators, guanine exchange modulators (GEMs). Among G proteins regulators, GEMs are uniquely capable of initiating pleiotropic signals: these bifunctional modulators can activate cAMP inhibitory (Gi) proteins and inhibit cAMP-stimulatory (Gs) proteins through a single short evolutionarily conserved module...
March 13, 2017: Cell Cycle
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