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Cell Cycle

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No abstract text is available yet for this article.
January 18, 2018: Cell Cycle
Jiong Ren, Cai-Zhi Tang, Xu-Dong Li, Zhi-Bin Niu, Bo-Yang Zhang, Tao Zhang, Mei-Jiao Gao, Xin-Ze Ran, Yong-Ping Su, Feng-Chao Wang
Although the regulatory network of G2/M phase transition has been intensively studied in mammalian cell lines, the identification of morphological and molecular markers to identify G2/M phase transition in vivo remains elusive. In this study, we found no obvious morphological changes between the S phase and G2 phase in mice intestinal epithelial cells. The G2 phase could be identified by Brdu incorporation resistance, marginal and scattered foci of histone H3 phosphorylated at Ser10 (pHH3), and relatively intact Golgi ribbon...
January 17, 2018: Cell Cycle
Ashley E Culver-Cochran, Daniel T Starczynowski
No abstract text is available yet for this article.
January 16, 2018: Cell Cycle
Yansen Li, Zhanlong Shen, Bo Wang, Chunxiang Ye, Zhiyong Lai, Hongpeng Jiang, Zhu Wang, Kewei Jiang, Yingjiang Ye, Shan Wang
Increasing evidence has shown that abnormal expression of lncRNAs is involved in various biological behaviors and major cellular pathways of human cancers. However, the role of lncRNAs in the progression of gastric cancer has not been adequately investigated. Therefore, in this study, we investigated the expression levels of linc-GPR65-1 using Quantitative real-time PCR (qRT-PCR) and found that linc-GPR65-1 was significantly up-regulated in 50 gastric cancer tissues compared to the corresponding normal tissues...
January 16, 2018: Cell Cycle
Simon Grelet, Renaud Geslain, Philip H Howe
No abstract text is available yet for this article.
January 15, 2018: Cell Cycle
Hassan Zalzali, Wisam Rabeh, Omar Najjar, Rami Abi Ammar, Mohamad Harajly, Raya Saab
The tumor suppressor p53, and the cyclin-dependent kinase inhibitor Ink4c, have been both implicated in spermatogenesis control. Both p53-/- and Ink4c-/- single knockout male mice are fertile, despite testicular hypertrophy, Leydig cell differentiation defect, and increased sperm count in Ink4c-/- males. To investigate their collaborative roles, we studied p53-/- Ink4c-/- dual knockout animals, and found that male p53-/- Ink4c-/- mice have profoundly reduced fertility. Dual knockout male mice show a marked decrease in sperm count, abnormal sperm morphology and motility, prolongation of spermatozoa proliferation and delay of meiosis entry, and accumulation of DNA damage...
January 15, 2018: Cell Cycle
Kentaro Miyake, Kei Kawaguchi, Tasuku Kiyuna, Masuyo Miyake, Kentaro Igarashi, Zhiying Zhang, Takashi Murakami, Yunfeng Li, Scott D Nelson, Irmina Elliott, Tara Russell, Arun Singh, Yukihiko Hiroshima, Masashi Momiyama, Ryusei Matsuyama, Takashi Chisima, Itaru Endo, Fritz C Eilber, Robert M Hoffman
Gastrointestinal stromal tumor (GIST) is a rare type of sarcoma. The aim of this study was to determine drug sensitivity for a regionally-recurrent case of GIST using a patient-derived orthotopic xenograft (PDOX) model. The PDOX model was established in the anterior wall of the stomach. GIST PDOX models were randomized into 5 groups of 6 mice each when the tumor volume reached 60 mm3: G1, control group; G2, imatinib group (oral administration (p.o.), daily, for 3 weeks); G3, sunitinib group (p.o., daily, for 3 weeks); G4, regorafenib (p...
January 15, 2018: Cell Cycle
Chiara Pederiva, Marianne Farnebo
No abstract text is available yet for this article.
January 11, 2018: Cell Cycle
Marine Theret, Linda Gsaier, Rémi Mounier
No abstract text is available yet for this article.
January 10, 2018: Cell Cycle
Meng Yue, Shiquan Li, Guoqiang Yan, Chenyao Li, Zhenhua Kang
Paeoniflorin (PF) exhibits tumor suppressive functions in a variety of human cancers. However, the function of PF and molecular mechanism in colorectal cancer are elusive. In the present study, we investigated whether PF could exert its antiproliferative activity, anti-migration, and anti-invasive function in colorectal cancer cells. We found that PF inhibited cell growth and induced apoptosis and blocked cell cycle progression in the G0/G1 phase in colorectal cancer cells. Moreover, we found that PF suppressed cell migration and invasion in colorectal cancer cells...
January 5, 2018: Cell Cycle
Jun Wang, Lihong Chang, Xiaoping Lai, Xia Li, Zhiyuan Wang, Zizhen Huang, Jiancong Huang, Gehua Zhang
The increasing resistance of nasopharyngeal carcinoma to irradiation makes the exploration of effective radiosensitizers necessary. Tetrandrine is known to be an antitumor drug, but little is known regarding its radiosensitization effect on nasopharyngeal carcinoma. We investigated the effect of combined treatment of irradiation and maximum non-cytotoxic doses of tetrandrine on the nasopharyngeal carcinoma cell lines CNE1 and CNE2. The maximum non-cytotoxic doses of tetrandrine in CNE1 and CNE2 cells were assessed using the MTT (3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide) assay...
December 29, 2017: Cell Cycle
Holly Edwards, Yubin Ge
No abstract text is available yet for this article.
December 29, 2017: Cell Cycle
Joonyoung Her, Chandni Ray, Samuel F Bunting
No abstract text is available yet for this article.
December 26, 2017: Cell Cycle
Stuart C Howes, Elisabeth A Geyer, Benjamin LaFrance, Rui Zhang, Elizabeth H Kellogg, Stefan Westermann, Luke M Rice, Eva Nogales
The cytoskeleton of eukaryotic cells relies on microtubules to perform many essential functions. We have previously shown that, in spite of the overall conservation in sequence and structure of tubulin subunits across species, there are differences between mammalian and budding yeast microtubules with likely functional consequences for the cell. Here we expand our structural and function comparison of yeast and porcine microtubules to show different distribution of protofilament number in microtubules assembled in vitro from these two species...
December 26, 2017: Cell Cycle
Amanda K Ashley, Christopher J Kemp
No abstract text is available yet for this article.
December 21, 2017: Cell Cycle
Xiaomei Hu, Zhe Li, Yuehe Ding, Qizhi Geng, Zhikai Xiahou, Huanwei Ru, Meng-Qiu Dong, Xingzhi Xu, Jing Li
Polo-like kinase 1 (Plk1) is an instrumental kinase that modulates many aspects of the cell cycle. Previous investigations have indicated that Plk1 is a target of the DNA damage response, and Plk1 inhibition is dependent on ATM/ATR and Chk1. But the exact mechanism remains elusive. In a proteomic screen to identify Chk1-interacting proteins, we found that myosin phosphatase targeting protein 1 (MYPT1) was present in the immunocomplex. MYPT1 is phosphorylated by CDK1, thus recruiting protein phosphatase 1β (PP1cβ) to dephosphorylate and inactivate Plk1...
December 20, 2017: Cell Cycle
Satoru Mimura, Yumiko Kubota, Haruhiko Takisawa
The minichromosome maintenance (MCM) complex, consisting of six subunits, Mcm2-7, is loaded onto replication origins through loading factors (origin recognition complex [ORC], Cdc6, and Cdt1) and forms an MCM double hexamer that licenses the initiation of DNA replication. Previous studies with Xenopus egg extracts showed that loading factors, especially Cdc6, dissociate from chromatin on MCM loading, but the molecular mechanism and physiological significance remain largely unknown. Using a cell-free system for MCM loading onto plasmid DNA in Xenopus egg extracts, we found that MCM loaded onto DNA prevents DNA binding of the loading factors ORC, Cdc6, and Cdt1...
December 20, 2017: Cell Cycle
Teresa M Dunn, Kenneth Gable, Gongshe Han
No abstract text is available yet for this article.
December 20, 2017: Cell Cycle
Giorgio Dieci, Roberto Ferrari
No abstract text is available yet for this article.
December 19, 2017: Cell Cycle
Nicolas Borisov, Victor Tkachev, Maria Suntsova, Olga Kovalchuk, Alex Zhavoronkov, Ilya Muchnik, Anton Buzdin
Personalized medicine implies that distinct treatment methods are prescribed to individual patients according several features that may be obtained from, e.g., gene expression profile. The majority of machine learning methods suffer from the deficiency of preceding cases, i.e. the gene expression data on patients combined with the confirmed outcome of known treatment methods. At the same time, there exist thousands of various cell lines that were treated with hundreds of anti-cancer drugs in order to check the ability of these drugs to stop the cell proliferation, and all these cell line cultures were profiled in terms of their gene expression...
December 18, 2017: Cell Cycle
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