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Cell Cycle

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https://www.readbyqxmd.com/read/28937881/isoform-specific-roles-of-nmii-drive-membrane-remodeling-in-vivo
#1
Seham Ebrahim, Oleg Milberg, Roberto Weigert
No abstract text is available yet for this article.
September 22, 2017: Cell Cycle
https://www.readbyqxmd.com/read/28937871/gas2l3-coordinator-of-cardiomyocyte-cytokinesis
#2
Marco Gr√ľndl, Felix B Engel, Stefan Gaubatz
No abstract text is available yet for this article.
September 22, 2017: Cell Cycle
https://www.readbyqxmd.com/read/28934018/autophagy-and-receptor-tyrosine-kinase-signalling-a-mtorc2-matter
#3
Aikaterini Lampada, Daniel Hochhauser, Paolo Salomoni
No abstract text is available yet for this article.
September 21, 2017: Cell Cycle
https://www.readbyqxmd.com/read/28934013/reconciling-conflicting-models-for-global-control-of-cell-cycle-transcription
#4
Chun-Yi Cho, Francis C Motta, Christina M Kelliher, Anastasia Deckard, Steven B Haase
Models for the control of global cell-cycle transcription have advanced from a CDK-APC/C oscillator, a transcription factor (TF) network, to coupled CDK-APC/C and TF networks. Nonetheless, current models were challenged by a recent study that concluded that the cell-cycle transcriptional program is primarily controlled by a CDK-APC/C oscillator in budding yeast. Here we report an analysis of the transcriptome dynamics in cyclin mutant cells that were not queried in the previous study. We find that B-cyclin oscillation is not essential for control of phase-specific transcription...
September 21, 2017: Cell Cycle
https://www.readbyqxmd.com/read/28934009/up-regulation-of-lyar-blocks-myc-induced-cell-death
#5
Shenglong Qiu, Pei Y Liu, Tao Liu
No abstract text is available yet for this article.
September 21, 2017: Cell Cycle
https://www.readbyqxmd.com/read/28933990/influence-of-salinomycin-treatment-on-division-and-movement-of-individual-cancer-cells-cultured-in-normoxia-or-hypoxia-evaluated-with-time-lapse-digital-holographic-microscopy
#6
Sofia Kamlund, Daniel Strand, Birgit Janicke, Kersti Alm, Stina Oredsson
Most studies on new cancer drugs are based on population-derived data, where the absence of response of a small population may pass unnoticed. Thus, individual longitudinal tracking of cells is important for the future development of efficient cancer treatments. We have used digital holographic microscopy to track individual JIMT-1 human breast cancer cells and L929 mouse fibroblast cultivated in normoxia or hypoxia. In addition, JIMT-1 cells were treated with salinomycin, a cancer stem cell targeting compound...
September 21, 2017: Cell Cycle
https://www.readbyqxmd.com/read/28933989/role-of-pex5-ubiquitination-in-maintaining-peroxisome-dynamics-and-homeostasis
#7
Wei Wang, Suresh Subramani
Peroxisomes are essential and dynamic organelles that allow cells to rapidly adapt and cope with changing environments and/or physiological conditions by modulation of both peroxisome biogenesis and turnover. Peroxisome biogenesis involves the assembly of peroxisome membranes and the import of peroxisomal matrix proteins. The latter depends on the receptor, PEX5, which recognizes peroxisomal matrix proteins in the cytosol directly or indirectly, and transports them to the peroxisomal lumen. In this review, we discuss the role of PEX5 ubiquitination in both peroxisome biogenesis and turnover, specifically in PEX5 receptor recycling, stability and abundance, as well as its role in pexophagy (autophagic degradation of peroxisomes)...
September 21, 2017: Cell Cycle
https://www.readbyqxmd.com/read/28933988/pwwp2a-a-novel-mitosis-link
#8
Stephanie Link, Sandra B Hake
No abstract text is available yet for this article.
September 21, 2017: Cell Cycle
https://www.readbyqxmd.com/read/28933987/rna-seq-analysis-provide-new-insights-into-mapk-signaling-of-apolipoproteinciii-induced-inflammation-in-porcine-vascular-endothelial-cells
#9
Yuan Yue, Hao Jiang, Shouqing Yan, Yao Fu, Chang Liu, Xulei Sun, Menglong Chai, Yan Gao, Bao Yuan, Chengzhen Chen, Lisheng Dai, Jiabao Zhang, Yu Ding
Apolipoprotein CIII (ApoCIII) has been shown to be associated with the inflammatory response, but the mechanism of its inflammatory effects remains unclear. Because vascular endothelial cells (VECs) play a key role in the development of inflammation, the present study was performed to investigate inflammatory mechanisms induced by ApoCIII in VECs. In this study, we screened differentially expressed genes (DEGs) using RNA-sequencing. The results identified 390 up-regulated genes and 257 down-regulated genes...
September 21, 2017: Cell Cycle
https://www.readbyqxmd.com/read/28933985/acn-1-a-c-elegans-homologue-of-ace-genetically-interacts-with-the-let-7-microrna-and-other-heterochronic-genes
#10
Chanatip Metheetrairut, Yuri Ahuja, Frank J Slack
The heterochronic pathway in C. elegans controls the relative timing of cell fate decisions during post-embryonic development. It includes a network of microRNAs (miRNAs), such as let-7, and protein-coding genes, such as the stemness factors, LIN-28 and LIN-41. Here we identified the acn-1 gene, a homologue of mammalian angiotensin-converting enzyme (ACE), as a new suppressor of the stem cell developmental defects of let-7 mutants. Since acn-1 null mutants die during early larval development, we used RNAi to characterize the role of acn-1 in C...
September 21, 2017: Cell Cycle
https://www.readbyqxmd.com/read/28933984/differentiation-of-lepidoptera-scale-cells-from-epidermal-stem-cells-followed-by-ecdysone-regulated-dna-duplication-and-scale-secreting
#11
Shenglei Yuan, Wuren Huang, Lei Geng, Brenda T Beerntsen, Hongsheng Song, Erjun Ling
Integuments are the first line to protect insects from physical damage and pathogenic infection. In lepidopteran insects, they undergo distinct morphology changes such as scale formation during metamorphosis. However, we know little about integument development and scale formation during this stage. Here, we use the silkworm, Bombyx mori, as a model and show that stem cells in the integument of each segment, but not intersegmental membrane, divide into two scale precursor cells during the spinning stage. In young pupae, the scale precursor cell divides again...
September 21, 2017: Cell Cycle
https://www.readbyqxmd.com/read/28933982/function-and-regulation-mechanism-of-chk1-during-meiotic-maturation-in-porcine-oocytes
#12
Zheng-Wen Nie, Li Chen, Qiu-Shi Jin, Ying-Ying Gao, Tao Wang, Xia Zhang, Yi-Liang Miao
Checkpoint 1 (Chk1), as an important member of DNA replication checkpoint and DNA damage response, has an important role during the G2/M stage of mitosis. In this study, we used porcine oocyte as a model to investigate the function of Chk1 during porcine oocyte maturation. Chk1 was expressed from germinal vesicle (GV) to metaphase II (MII) stages, mainly localized in the cytoplasm at GV stage and moved to the spindle after germinal vesicle breakdown (GVBD). Chk1 depletion not only induced oocytes to be arrested at MI stage with abnormal chromosomes arrangement, but also inhibited the degradation of Cyclin B1 and decreased the expression of Mitotic Arrest Deficient 2-Like 1 (Mad2L1), one of spindle assembly checkpoint (SAC) proteins, and cadherin 1 (Cdh1), one of coactivation for anaphase-promoting complex/cyclosome (APC/C)...
September 21, 2017: Cell Cycle
https://www.readbyqxmd.com/read/28933981/tfpi2as1-a-novel-lncrna-that-inhibits-cell-proliferation-and-migration-in-lung-cancer
#13
Shenglan Gao, Ziying Lin, Chunyan Li, Yahong Wang, Lawei Yang, Baoan Zou, Jie Chen, Jianwen Li, Zeqing Song, Gang Liu
Accumulating evidence demonstrates that a series of differentially expressed lncRNAs is important in tumorigenesis. However, the function of many of the lncRNAs in lung cancer remains elusive. In the present study, we used microarray analysis to identify lncRNAs that are dysregulated in non-small-cell lung cancer (NSCLC) as compared with normal tissues. Among the dysregulated lncRNAs, we identified TFPI2AS1, an antisense transcript of the tumor suppressor TFPI2 (tissue factor pathway inhibitor 2). TFPI2AS1 was shown to be markedly upregulated in NSCLC patient tumors as compared to paired non-tumor samples...
September 21, 2017: Cell Cycle
https://www.readbyqxmd.com/read/28933683/epithelial-integrity-and-cell-division-concerted-cell-cycle-control
#14
Katerina Ragkousi, Matthew C Gibson
No abstract text is available yet for this article.
September 21, 2017: Cell Cycle
https://www.readbyqxmd.com/read/28933615/role-of-dicer1-in-thyroid-cell-proliferation-and-differentiation
#15
Ricardo Cortez Cardoso Penha, Romina Sepe, Marco De Martino, Francesco Esposito, Simona Pellecchia, Maddalena Raia, Luigi Del Vecchio, Myriam Decaussin-Petrucci, Gabriella De Vita, Luis Felipe Ribeiro Pinto, Alfredo Fusco
DICER1 plays a central role in the biogenesis of microRNAs and it is important for normal development. Altered microRNA expression and DICER1 dysregulation have been described in several types of tumors, including thyroid carcinomas. Recently, our group identified a new somatic mutation (c.5438A>G; E1813G) within DICER1 gene of an unknown function. Herein, we show that DICER1 is overexpressed, at mRNA level, in a significant-relative number of papillary (70%) and anaplastic (42%) thyroid carcinoma samples, whereas is drastically downregulated in all the analyzed human thyroid carcinoma cell lines (TPC-1, BCPAP, FRO and 8505c) in comparison with normal thyroid tissue samples...
September 21, 2017: Cell Cycle
https://www.readbyqxmd.com/read/28933599/skap2-regulates-arp2-3-complex-for-actin-mediated-asymmetric-cytokinesis-by-interacting-with-wave2-in-mouse-oocytes
#16
Shu-Wen He, Bai-Hui Xu, Yu Liu, Ya-Long Wang, Ming-Huang Chen, Lin Xu, Bao-Qiong Liao, Rui Lui, Fei-Ping Li, Yan-Hong Lin, Xian-Pei Fu, Bin-Bin Fu, Zi-Wei Hong, Yu-Xin Liu, Zhong-Quan Qi, Hai-Long Wang
SKAP2 (Src kinase-associated phosphoprotein 2), a substrate of Src family kinases, has been suggested to be involved in actin-mediated cellular processes. However, little is known about its role in mouse oocyte maturation. In this study, we thus investigated the expression, localization, and functions of SKAP2 during mouse oocyte asymmetric division. SKAP2 protein expression was detected at all developmental stages in mouse oocytes. Immunofluorescent staining showed that SKAP2 was mainly distributed at the cortex of the oocytes during maturation...
September 21, 2017: Cell Cycle
https://www.readbyqxmd.com/read/28933594/chloride-intracellular-channel-3-a-secreted-pro-invasive-oxidoreductase
#17
Jim Norman, Sara Zanivan
No abstract text is available yet for this article.
September 21, 2017: Cell Cycle
https://www.readbyqxmd.com/read/28933593/dynein-promotes-porcine-oocyte-meiotic-progression-by-maintaining-cytoskeletal-structures-and-cortical-granule-arrangement
#18
Yilong Miao, Changyin Zhou, Zhaokang Cui, Liansheng Tang, Xiayan ShiYang, Yajuan Lu, Mianqun Zhang, Xiaoxin Dai, Bo Xiong
Cytoplasmic dynein is a family of cytoskeletal motor proteins that move towards the minus-end of the microtubules to perform functions in a variety of mitotic processes such as cargo transport, organelle positioning, chromosome movement and centrosome assembly. However, its specific roles during mammalian oocyte meiosis have not been fully defined. Herein, we investigated the critical events during porcine oocyte meiotic maturation after inhibition of dynein by Ciliobrevin D treatment. We found that oocyte meiotic progression was arrested when inhibited of dynein by showing the poor expansion of cumulus cells and decreased rate of polar body extrusion...
September 21, 2017: Cell Cycle
https://www.readbyqxmd.com/read/28933592/stat3-regulated-rhoa-drives-reactive-astrocyte-dynamics
#19
Francois Renault-Mihara, Hideyuki Okano
No abstract text is available yet for this article.
September 21, 2017: Cell Cycle
https://www.readbyqxmd.com/read/28933589/mtr4-zfc3h1-protects-polysomes-through-nuclear-rna-surveillance
#20
Koichi Ogami, James L Manley
No abstract text is available yet for this article.
September 21, 2017: Cell Cycle
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