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https://www.readbyqxmd.com/read/28636464/understanding-the-pluses-of-pulses
#1
Jessica Miciak, Fred Bunz
No abstract text is available yet for this article.
June 21, 2017: Cell Cycle
https://www.readbyqxmd.com/read/28636420/tirr-and-53bp1-partners-in-arms
#2
Pascal Drané, Dipanjan Chowdhury
No abstract text is available yet for this article.
June 21, 2017: Cell Cycle
https://www.readbyqxmd.com/read/28636416/akt-modulates-the-autophagy-lysosome-pathway-via-tfeb
#3
Michela Palmieri, Rituraj Pal, Marco Sardiello
No abstract text is available yet for this article.
June 21, 2017: Cell Cycle
https://www.readbyqxmd.com/read/28632999/long-noncoding-rna-lnc-sox5-modulates-crc-tumorigenesis-by-unbalancing-tumor-microenvironment
#4
Wu Kaiming, Zhenxian Zhao, Kuanzhi Liu, Jian Zhang, Guanghua Li, Liang Wang
Long non-coding RNAs (LncRNAs) have been recently regarded as systemic regulators in multiple biological processes including tumorigenesis. In this study, we observed the expression of lncRNA lnc-sox5 was significantly increased in colorectal cancer (CRC). Despite the CRC cell growth, cell cycle and cell apoptosis was not affected by lnc-sox5 knock-down, lnc-sox5 knock-down suppressed CRC cell migration and invasion. In addition, xenograft animal model suggested that lnc-sox5 knock-down significantly suppressed the CRC tumorigenesis...
June 20, 2017: Cell Cycle
https://www.readbyqxmd.com/read/28622068/salmonella-typhimurium-a1-r-targeting-of-a-chemotherapy-resistant-braf-v600e-melanoma-in-a-patient-derived-orthotopic-xenograft-pdox-model-is-enhanced-in-combination-with-either-vemurafenib-temozlomide
#5
Kei Kawaguchi, Kentaro Igarashi, Bartosz Chmielowski, Takashi Murakami, Tasuku Kiyuna, Ming Zhao, Yong Zhang, Scott D Nelson, Tara A Russell, Sarah M Dry, Arun S Singh, Yunfeng Li, Michiaki Unno, Fritz C Eilber, Robert M Hoffman
A metastatic melanoma obtained from the right chest wall of a patient was previously established orthotopically in the right chest wall of nude mice as a patient-derived orthotopic xenograft (PDOX) model. We previously showed that the combination of tumor targeting Salmonella typhimurium A1-R (S. typhimurium A1-R) and chemotherapy was highly effective against the melanoma PDOX. In the present study, we investigated the mechanism of the high efficacy of this combination. Two weeks after implantation, 40 PDOX mouse models were randomized into four groups of 10 mice each: untreated control (n = 10); treated with S...
June 16, 2017: Cell Cycle
https://www.readbyqxmd.com/read/28598299/proper-sister-chromatid-disjunction-requires-cda-and-parp-1
#6
Jean-Sébastien Hoffmann, Pierre Cordelier
No abstract text is available yet for this article.
June 9, 2017: Cell Cycle
https://www.readbyqxmd.com/read/28598241/critical-histone-post-translational-modifications-for-centromere-function-and-propagation
#7
Tatsuo Fukagawa
The centromere is a critical genomic region that enables faithful chromosome segregation during mitosis, and must be distinguishable from other genomic regions to facilitate establishment of the kinetochore. The centromere-specific histone H3-variant CENP-A forms a special nucleosome that functions as a marker for centromere specification. In addition to the CENP-A nucleosomes, there are additional H3 nucleosomes that have been identified in centromeres, both of which are predicted to exhibit specific features...
June 9, 2017: Cell Cycle
https://www.readbyqxmd.com/read/28598238/nlrc3-regulates-cellular-proliferation-and-apoptosis-to-attenuate-the-development-of-colorectal-cancer
#8
Rajendra Karki, R K Subbarao Malireddi, Qifan Zhu, Thirumala-Devi Kanneganti
Nucleotide-binding domain, leucine-rich-repeat-containing proteins (NLRs) are intracellular innate immune sensors of pathogen-associated and damage-associated molecular patterns. NLRs regulate diverse biological processes such as inflammatory responses, cell proliferation and death, and gut microbiota to attenuate tumorigenesis. In a recent publication in Nature, we identified NLRC3 as a negative regulator of PI3K-mTOR signaling and characterized its potential tumor suppressor function. Enterocytes lacking NLRC3 cannot control cellular proliferation because they are unable to suppress activation of PI3K-mTOR signaling pathways...
June 9, 2017: Cell Cycle
https://www.readbyqxmd.com/read/28598228/hdac6-inhibition-disrupts-maturational-progression-and-meiotic-apparatus-assembly-in-mouse-oocytes
#9
Li Ling, Feifei Hu, Xiaoyan Ying, Juan Ge, Qiang Wang
Histone deacetylases (HDACs) have been implicated in diverse biological processes including transcriptional regulation, signal transduction, and developmental control. However, the role of HDAC6 in mammalian oocytes remains unknown. In the present study, by employing Tubastatin A (TubA), a selective HDAC6 inhibitor, we examined the effects of HDAC6 on maturational progression and meiotic apparatus in mouse oocytes. We found that HDAC6 inhibition results in maturation arrest and disruption of spindle morphology and chromosome alignment...
June 9, 2017: Cell Cycle
https://www.readbyqxmd.com/read/28594296/the-p53-r72p-polymorphism-does-not-affect-the-physiological-response-to-ionizing-radiation-in-a-mouse-model
#10
Emily R Domínguez, Jennifer Orona, Kevin Lin, Carlos J Pérez, Fernando Benavides, Donna F Kusewitt, David G Johnson
Tissue culture and mouse model studies show that the presence of the arginine (R) or proline (P) coding single nucleotide polymorphism (SNP) of the tumor suppressor gene p53 at codon 72 (p53 R72P) differentially affects the responses to genotoxic insult. Compared to the P variant, the R variant shows increased apoptosis in most cell cultures and mouse model tissues in response to genotoxins, and epidemiological studies suggest that the R variant may enhance cancer survival and reduce the risks of adverse reactions to genotoxic cancer treatment...
June 8, 2017: Cell Cycle
https://www.readbyqxmd.com/read/28594273/effect-of-tpa-and-htlv-1-tax-on-brca1-and-ere-controlled-genes-expression
#11
Azhar Jabareen, Aya Abu-Jaafar, Ammar Abou-Kandil, Mahmoud Huleihel
Interference with the expression and/or functions of the multifunctional tumor suppressor BRCA1 leads to a high risk of breast and ovarian cancers. BRCA1 expression is usually activated by the estrogen (E2) liganded ERα receptor. Activated ERα is considered as a potent transcription factor which activates various genes expression by two pathways. A classical pathway, ERα binds directly to E2-responsive elements (EREs) in the promoters of the responsive genes and a non-classical pathway where ERα indirectly binds with the appropriate gene promoter...
June 8, 2017: Cell Cycle
https://www.readbyqxmd.com/read/28594265/%C3%AE-cell-self-renewal-cyclin-d2-to-the-rescue
#12
Naureen Javeed, Aleksey V Matveyenko
No abstract text is available yet for this article.
June 8, 2017: Cell Cycle
https://www.readbyqxmd.com/read/28594262/an-analysis-of-gene-expression-data-involving-examination-of-signaling-pathways-activation-reveals-new-insights-into-the-mechanism-of-action-of-minoxidil-topical-foam-in-men-with-androgenetic-alopecia
#13
Georgios N Stamatas, Jeff Wu, Apostolos Pappas, Paradi Mirmirani, Thomas S McCormick, Kevin D Cooper, Mary Consolo, Jane Schastnaya, Ivan Ozerov, Alexander Aliper, Alex Zhavoronkov
Androgenetic alopecia is the most common form of hair loss. Minoxidil has been approved for the treatment of hair loss, however its mechanism of action is still not fully clarified. In this study, we aimed to elucidate the effects of 5% minoxidil topical foam on gene expression and activation of signaling pathways in vertex and frontal scalp of men with androgenetic alopecia. We identified regional variations in gene expression and perturbed signaling pathways using in silico Pathway Activation Network Decomposition Analysis (iPANDA) before and after treatment with minoxidil...
June 8, 2017: Cell Cycle
https://www.readbyqxmd.com/read/28594259/targeting-cdk4-6-to-oppose-hypoxia-mediated-therapeutic-resistance
#14
Noel A Warfel
No abstract text is available yet for this article.
June 8, 2017: Cell Cycle
https://www.readbyqxmd.com/read/28594256/nitidine-chloride-inhibited-the-expression-of-s-phase-kinase-associated-protein-2-in-ovarian-cancer-cells
#15
Huaping Mou, Ping Guo, Xiaoming Li, Chuanli Zhang, Jing Jiang, Lishuai Wang, Qiu Wang, Zhiping Yuan
Nitidine chloride (NC) has been reported to exert its anti-tumor activity in various types of human cancers. However, the molecular mechanism of NC-mediated tumor suppressive function is largely unclear. In the current study, we used several approaches such as MTT, FACS, RT-PCR, Western blotting analysis, invasion assay, transfection, to explore the molecular basis of NC-triggered anti-cancer activity. We found that NC inhibited cell growth, induced cell apoptosis, caused cell cycle arrest in ovarian cancer cells...
June 8, 2017: Cell Cycle
https://www.readbyqxmd.com/read/28594255/the-human-mitochondrial-hsp60-in-the-apo-conformation-forms-a-stable-tetradecameric-complex
#16
Adrian S Enriquez, Humberto M Rojo, Jay M Bhatt, Sudheer K Molugu, Zacariah L Hildenbrand, Ricardo A Bernal
The human mitochondrial chaperonin is a macromolecular machine that catalyzes the proper folding of mitochondrial proteins and is of vital importance to all cells. This chaperonin is composed of 2 distinct proteins, Hsp60 and Hsp10, that assemble into large oligomeric complexes that mediate the folding of non-native polypeptides in an ATP dependent manner. Here, we report the bacterial expression and purification of fully assembled human Hsp60 and Hsp10 recombinant proteins and that Hsp60 forms a stable tetradecameric double-ring conformation in the absence of co-chaperonin and nucleotide...
June 8, 2017: Cell Cycle
https://www.readbyqxmd.com/read/28594251/timely-regulated-intron-retention-as-device-to-fine-tune-protein-expression
#17
Chiara Naro, Claudio Sette
No abstract text is available yet for this article.
June 8, 2017: Cell Cycle
https://www.readbyqxmd.com/read/28590839/contractility-differential-tension-and-membrane-removal-lead-zebrafish-epiboly-biomechanics
#18
Maria Marsal, Amayra Hernández-Vega, Enrique Martin-Blanco
Precise tissue remodeling during development is essential for shaping embryos and optimal organ function. Epiboly is an early gastrulation event by which the blastoderm expands around the yolk to engulf it. Three different layers are involved in this process, an epithelial layer (the enveloping layer, EVL), the embryo proper, constituted by the deep cells (DCs), and the yolk cell. Although teleost epiboly has been studied for many years, a clear understanding of its mechanics was still missing. Here we present new information on the cellular, molecular and mechanical elements involved in epiboly that, together with some other recent data and upon comparison with previous biomechanical models, lets conclude that the expansion of the epithelia is passive and driven by active cortical contraction and membrane removal in the adjacent layer, the External Yolk Syncytial Layer (E-YSL)...
June 7, 2017: Cell Cycle
https://www.readbyqxmd.com/read/28590163/merotelic-kinetochore-attachment-in-oocyte-meiosis-ii-causes-sister-chromatids-segregation-errors-in-aged-mice
#19
Jin-Mei Cheng, Jian Li, Ji-Xin Tang, Xiao-Xia Hao, Zhi-Peng Wang, Tie-Cheng Sun, Xiu-Xia Wang, Yan Zhang, Su-Ren Chen, Yi-Xun Liu
Mammalian oocyte chromosomes undergo two meiotic divisions to generate haploid gametes. The frequency of chromosome segregation errors during meiosis I increase with age. However, little attention has been paid to the question of how aging affects sister chromatid segregation during oocyte meiosis II. More importantly, how aneuploid metaphase II (MII) oocytes from aged mice evade the spindle assembly checkpoint (SAC) mechanism to complete later meiosis II to form aneuploid embryos remains unknown. Here, we report that MII oocytes from naturally aged mice exhibited substantial errors in chromosome arrangement and configuration compared with young MII oocytes...
June 7, 2017: Cell Cycle
https://www.readbyqxmd.com/read/28562206/lipopolysaccharide-induces-the-differentiation-of-hepatic-progenitor-cells-into-myofibroblasts-via-activation-of-the-hedgehog-signalling-pathway
#20
Xiao-Rong Pan, Ying-Ying Jing, Wen-Ting Liu, Zhi-Peng Han, Rong Li, Yang Yang, Jing-Ni Zhu, Xiao-Yong Li, Pei-Pei Li, Li-Xin Wei
Normally, hepatic progenitor cells (HPCs) are activated and differentiate into hepatocytes or bile ductular cells to repair liver damage during liver injury. However, it remains controversial whether the abnormal differentiation of HPCs occurs under abnormal conditions. Lipopolysaccharide (LPS), a component of the microenvironment, promotes liver fibrosis. In the present study, HPCs promoted liver fibrosis in rats following carbon tetrachloride (CCl4) treatment. Meanwhile, the LPS level in the portal vein was elevated and played a primary role in the fate of HPCs...
May 31, 2017: Cell Cycle
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