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Circulation Journal: Official Journal of the Japanese Circulation Society

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https://www.readbyqxmd.com/read/28794352/thalidomide-for-hereditary-hemorrhagic-telangiectasia-with-pulmonary-arterial-hypertension
#1
Tomohisa Nakamura, Takeshi Ogo, Nobuhiro Tahara, Shigefumi Fukui, Akihiro Tsuji, Jin Ueda, Yoshihiro Fukumoto, Norifumi Nakanishi, Hisao Ogawa, Satoshi Yasuda
No abstract text is available yet for this article.
August 10, 2017: Circulation Journal: Official Journal of the Japanese Circulation Society
https://www.readbyqxmd.com/read/28794354/message-from-the-editor-in-chief
#2
Toyoaki Murohara
No abstract text is available yet for this article.
August 9, 2017: Circulation Journal: Official Journal of the Japanese Circulation Society
https://www.readbyqxmd.com/read/28794353/revascularization-of-left-coronary-system-using-a-skeletonized-left-internal-mammary-artery%C3%A3-sequential-vs-separate-grafting
#3
Qiang Ji, YunQing Shi, LiMin Xia, RunHua Ma, JinQiang Shen, Hao Lai, WenJun Ding, ChunSheng Wang
BACKGROUND: To evaluate in-hospital and mid-term outcomes of sequential vs. separate grafting of in situ skeletonized left internal mammary artery (LIMA) to the left coronary system in a single-center, propensity-matched study.Methods and Results:After propensity score-matching, 120 pairs of patients undergoing first scheduled isolated coronary artery bypass grafting (CABG) with in situ skeletonized LIMA grafting to the left anterior descending artery (LAD) territory were entered into a sequential group (sequential grafting of LIMA to the diagonal artery and then to the LAD) or a control group (separate grafting of LIMA to the LAD)...
August 9, 2017: Circulation Journal: Official Journal of the Japanese Circulation Society
https://www.readbyqxmd.com/read/28794386/overview-of-the-81-st-annual-scientific-meeting-of-the-japanese-circulation-society%C3%A3-cardiovascular-medicine-for-the-next-generation
#4
Noboru Fujino, Tsuyoshi Yoshimuta, Fukiko Ichida, Koichiro Kinugawa, Kazuo Usuda, Michihiko Kitayama, Hidekazu Ino, Masa-Aki Kawashiri, Hiroshi Tada, Sumio Mizuno, Kenshi Hayashi, Hirofumi Takemura, Masakazu Yamagishi
The 81(st)Annual Scientific Meeting of the Japanese Circulation Society was held in Kanazawa, Japan, on March 17-19, 2017 under a miraculously clear sky. The frontlines of healthcare and medicine are dramatically changing. Thus, "Cardiovascular Medicine for Next Generation" was chosen as the main theme of this meeting. The program was constructed around major identified issues, including renewal of our understanding of basic cardiovascular medicine, translational research, and preventive molecular medicine, all of which are anticipated to transcend the medical field over the next generation...
August 8, 2017: Circulation Journal: Official Journal of the Japanese Circulation Society
https://www.readbyqxmd.com/read/28794385/association-between-a-ccl17-genetic-variant-and-risk-of-coronary-artery-disease-in-a-chinese-han-population
#5
Yicong Ye, Xinglin Yang, Bo Long, Haiyu Pang, Yicheng Zhu, Shuyang Zhang
BACKGROUND: In the present study we investigated the effects of genetic variations in the C-C motif chemokine ligand 17 (CCL17) gene on serum CCL17 levels and risk of coronary artery disease (CAD).Methods and Results:A case-control study was conducted to determine causal inferences amongCCL17single-nucleotide polymorphisms (SNPs), serum CCL17 levels, and risk of CAD. Luciferase assays, electrophoretic mobility shift assays (EMSA), and allele-specific quantitative chromatin immunoprecipitation (ChIP) assays were used to assess the function of the SNPs...
August 8, 2017: Circulation Journal: Official Journal of the Japanese Circulation Society
https://www.readbyqxmd.com/read/28768922/preoperative-assessment-of-endothelial-function-for-prediction-of-adverse-events-after-cardiovascular-surgery
#6
Yuichi Saito, Hideki Kitahara, Goro Matsumiya, Yoshio Kobayashi
BACKGROUND: Cardiovascular surgery is one of the highest risk procedures in the field of surgery. Preoperative assessment of endothelial function has been reported as useful for predicting postoperative adverse events (AEs). The aim of this study was to investigate the relationship between endothelial function assessed by reactive hyperemia index (RHI) and AEs after cardiovascular surgery.Methods and Results:A prospective observational study of 197 patients who underwent cardiovascular surgery was conducted...
August 3, 2017: Circulation Journal: Official Journal of the Japanese Circulation Society
https://www.readbyqxmd.com/read/28768921/efficacy-and-safety-of-the-cholesteryl-ester-transfer-protein-inhibitor-evacetrapib-in-combination-with-atorvastatin-in-japanese-patients-with-primary-hypercholesterolemia
#7
Tamio Teramoto, Arihiro Kiyosue, Takeshi Iimura, Yasushi Takita, Jeffrey S Riesmeyer, Masahiro Murakami
BACKGROUND: Inhibition of cholesteryl ester transfer protein by evacetrapib when added to atorvastatin may provide an additional treatment option for patients who do not reach their low-density lipoprotein cholesterol (LDL-C) goal.Methods and Results:This multicenter, randomized, 12-week, double-blind, parallel-group, placebo-controlled, outpatient, phase 3 study evaluated the efficacy of evacetrapib with atorvastatin in reducing LDL-C in 149 Japanese patients (evacetrapib/atorvastatin, n=53; ezetimibe/atorvastatin, n=50; placebo/atorvastatin, n=46) with primary hypercholesterolemia...
August 3, 2017: Circulation Journal: Official Journal of the Japanese Circulation Society
https://www.readbyqxmd.com/read/28768917/efficacy-and-safety-of-switching-from-oral-bisoprolol-to-transdermal-patch-in-japanese-patients-with-chronic-heart-failure
#8
Shin-Ichi Momomura, Yoshihiko Saito, Yoshio Yasumura, Kazuhiro Yamamoto, Yasushi Sakata, Masao Daimon, Koichiro Kinugawa, Hiroshi Okamoto, Naoki Dohi, Issei Komuro
BACKGROUND: TY-0201 (TY) is a transdermal formulation of bisoprolol that is the free base of bisoprolol fumarate (BO), a drug widely used to treat chronic heart failure (CHF). The objectives of this phase II study were to evaluate the efficacy and safety of TY when switching from oral BO to TY in patients with CHF whose drug therapy was optimized, and to determine the dose conversion rate of BO to TY.Methods and Results:The efficacy and safety of once daily TY patch use for 16 weeks was investigated in 40 patients with CHF who were stabilized with an optimized drug treatment, including BO, after switching from BO to TY at the dose conversion rate of 5:8...
August 2, 2017: Circulation Journal: Official Journal of the Japanese Circulation Society
https://www.readbyqxmd.com/read/28757520/role-of-routine-follow-up-coronary-angiography-after-percutaneous-coronary-intervention%C3%A3-systematic-review-and-meta-analysis
#9
Naoki Misumida, Akihiro Kobayashi, Sun Moon Kim, Ahmed Abdel-Latif, Khaled M Ziada
BACKGROUND: Prior studies have shown that routine follow-up coronary angiography (CAG) following percutaneous coronary intervention (PCI) increases the incidence of revascularization without a clear reduction in major adverse clinical events. However, none of these prior studies were adequately powered to evaluate hard clinical endpoints such as myocardial infarction (MI) or death and thus the clinical utility of such practice remains to be determined.Methods and Results:We conducted a systematic review and meta-analysis of randomized trials that compared clinical outcomes after PCI between patients who underwent routine follow-up CAG and those who only had clinical follow-up...
July 29, 2017: Circulation Journal: Official Journal of the Japanese Circulation Society
https://www.readbyqxmd.com/read/28757519/protruding-in-stent-mass-after-bioresorbable-polymer-sirolimus-eluting-stent%C3%A3-ex-vivo-intravascular-imaging-and-histopathology
#10
Rika Kawakami, Takahiro Imanaka, Masaharu Ishihara, Takako Kihara, Kenichi Fujii, Seiichi Hirota, Hiroyuki Hao
No abstract text is available yet for this article.
July 29, 2017: Circulation Journal: Official Journal of the Japanese Circulation Society
https://www.readbyqxmd.com/read/28757518/pathological-quantification-of-carotid-artery-plaque-instability-in-patients-undergoing-carotid-endarterectomy
#11
Takao Konishi, Naohiro Funayama, Tadashi Yamamoto, Tohru Morita, Daisuke Hotta, Ryota Nomura, Yusuke Nakagaki, Takeo Murahashi, Kenji Kamiyama, Tetsuyuki Yoshimoto, Takeshi Aoki, Hiroshi Nishihara, Shinya Tanaka
BACKGROUND: Unstable atherosclerotic carotid plaques cause cerebral thromboemboli and ischemic events. However, this instability has not been pathologically quantified, so we sought to quantify it in patients undergoing carotid endarterectomy (CEA).Methods and Results:Carotid plaques were collected during CEA from 67 symptomatic and 15 asymptomatic patients between May 2015 and August 2016. The specimens were stained with hematoxylin-eosin and elastica-Masson. Immunohistochemistry was performed using an endothelial-specific antibody to CD31, CD 34 and PDGFRβ...
July 29, 2017: Circulation Journal: Official Journal of the Japanese Circulation Society
https://www.readbyqxmd.com/read/28747614/pyogenic-aortitis%C3%A3-role-of-18f-fdg-positron-emission-tomography-computed-tomography-in-aortic-infection-imaging
#12
Alejandro Travieso-González, Isidre Vilacosta, David Vivas, Carmen Olmos, Javier Higueras Nafría, María Jesús Pérez Castejón, Aída Ortega Candil, Adela Pelayo Alarcón, Luis Ortega Medina
No abstract text is available yet for this article.
July 26, 2017: Circulation Journal: Official Journal of the Japanese Circulation Society
https://www.readbyqxmd.com/read/28747613/increased-carotid-artery-lesion-inflammation-upon-treatment-with-the-cd137-agonistic-antibody-2a
#13
Leif Å Söderström, Hong Jin, April S Caravaca, Maria L Klement, Yuhuang Li, Anton Gisterå, Ulf Hedin, Lars Maegdefessel, Göran K Hansson, Peder S Olofsson
BACKGROUND: Increased inflammatory activity destabilizes the atherosclerotic lesion and may lead to atherothrombosis and symptomatic cardiovascular disease. Co-stimulatory molecules, such as CD137, are key regulators of inflammation, and CD137 activity regulates inflammation in experimental atherosclerosis. Here, we hypothesized that CD137 activation promotes carotid artery inflammation and atherothrombosis.Methods and Results:In a model of inducible atherothrombosis with surgical ligation of the right carotid artery and a subsequent placement of a polyethene cuff, elevated levels of CD137 and CD137 ligand mRNA in atherothrombotic vs...
July 26, 2017: Circulation Journal: Official Journal of the Japanese Circulation Society
https://www.readbyqxmd.com/read/28747612/effectiveness-and-outcome-of-pulmonary-arterial-hypertension-specific-therapy-in-japanese-patients-with-pulmonary-arterial-hypertension
#14
Yuichi Tamura, Hiraku Kumamaru, Toru Satoh, Hiroaki Miyata, Aiko Ogawa, Nobuhiro Tanabe, Masaru Hatano, Atsushi Yao, Kohtaro Abe, Ichizo Tsujino, Keiichi Fukuda, Hiroshi Kimura, Masataka Kuwana, Hiromi Matsubara, Koichiro Tatsumi
BACKGROUND: The trend of the initial treatment strategy for pulmonary arterial hypertension (PAH) has changed from monotherapies to upfront combination therapies. This study analyzed treatments and outcomes in Japanese patients with PAH, using data from the Japan PH Registry (JAPHR), which is the first organized multicenter registry for PAH in Japan.Methods and Results:We studied 189 consecutive patients (108 treatment-naïve and 81 background therapy patients) with PAH in 8 pulmonary hypertension (PH) centers enrolled from April 2008 to March 2013...
July 26, 2017: Circulation Journal: Official Journal of the Japanese Circulation Society
https://www.readbyqxmd.com/read/28747611/histone-deacetylase-1-inhibition-protects-against-hypoxia-induced-swelling-in-h9c2-cardiomyocytes-through-regulating-cell-stiffness
#15
Yi Li, Zhengyi Zhang, Xiangnan Zhou, Rui Li, Yan Cheng, Bo Shang, Yu Han, Bin Liu, Xiaodong Xie
BACKGROUND: The process of cardiomyocyte swelling involves changes of biomechanical properties and profiles of cellular genes. Although many genes have been proved to regulate cell edema of cardiomyocyte, the mechanisms involved in this event, as well as the biomechanical properties of swelling cell, remain unknown.Methods and Results:Whether histone deacetylase 1 (HDAC1) inhibition protects against hypoxia-induced H9c2 cardiomyocyte swelling is examined in this study. Hypoxia-induced changes in the biomechanical properties and cytoskeletal structure that are relevant to cell swelling were also determined...
July 26, 2017: Circulation Journal: Official Journal of the Japanese Circulation Society
https://www.readbyqxmd.com/read/28724839/effect-of-recurrent-mitral-regurgitation-after-mitral-valve-repair-in-patients-with-degenerative-mitral-regurgitation
#16
Jung-Hwan Kim, Seung Hyun Lee, Hyun-Chel Joo, Young-Nam Youn, Kyung-Jong Yoo, Byung-Chul Chang, Sak Lee
BACKGROUND: This study investigated the consequences of recurrent mitral regurgitation (MR) after mitral valve (MV) repair in patients with degenerative MR and risk factors for recurrence.Methods and Results:From January 1990 to December 2015, 792 patients underwent MV repair due to degenerative MR. Recurrent MR was defined as moderate-to-severe MR on follow-up echocardiography. Mean follow-up duration was 8.71±5.58 years. During the follow-up period, MR recurred in 133 (16.8%) patients, and the MR recurrence-free rate at 20 years was 77...
July 20, 2017: Circulation Journal: Official Journal of the Japanese Circulation Society
https://www.readbyqxmd.com/read/28724838/csk-regulates-blood-pressure-by-controlling-the-synthetic-pathways-of-aldosterone
#17
Sung-Moon Kim, Ji-One Kang, Ji Eun Lim, Sue-Yun Hwang, Bermseok Oh
BACKGROUND: Blood pressure is regulated by a network of diverse physiological pathways. The C-terminal Src kinase (CSK) locus (15q24) is associated with blood pressure in various ethnic groups. It was recently reported thatCskinsufficiency increases blood pressure through Src. The mechanisms of hypertension inCsk(+/-)mice are examined further in this study.Methods and Results:To identify a causal component responsible for hypertension inCsk(+/-), the heart rate was measured by electrocardiogram and plasma volume by Evans blue dilution...
July 20, 2017: Circulation Journal: Official Journal of the Japanese Circulation Society
https://www.readbyqxmd.com/read/28724836/prothrombin-complex-concentrate-for-vitamin-k-antagonist-associated-intracranial-hemorrhage%C3%A3-global-evidence-and-the-japanese-perspective
#18
Masahiro Yasaka, Andres Brainsky, Kazunori Toyoda
Patients receiving vitamin K antagonists (VKAs) are at increased risk of bleeding. Intracranial hemorrhage (ICH) is a major cause of morbidity and mortality in this population, and is a particular concern among Japanese clinicians, given reports of an elevated risk of this bleeding type in patients of Asian ethnicity. Patients with VKA-associated ICH require rapid international normalized ratio (INR) reversal, and treatment guidelines suggest the use of prothrombin complex concentrates (PCCs) or plasma for this purpose...
July 19, 2017: Circulation Journal: Official Journal of the Japanese Circulation Society
https://www.readbyqxmd.com/read/28717067/barthel-index-and-outcome-of-open-bypass-for-critical-limb-ischemia
#19
Shinsuke Mii, Atsushi Guntani, Eisuke Kawakubo, Hirofumi Shimazoe
BACKGROUND: Daily activity should be an important factor to consider when deciding on a treatment strategy for critical limb ischemia (CLI), and we hypothesized that there was a close relationship between activities of daily living (ADL) and prognosis. The aim of this study was to investigate the association between ADL and outcomes of open bypass for CLI.Methods and Results:A total of 226 patients undergoing infrainguinal bypass for CLI between January 2005 and December 2015 were reviewed...
July 15, 2017: Circulation Journal: Official Journal of the Japanese Circulation Society
https://www.readbyqxmd.com/read/28717068/first-in-man-trial-of-sio2-inert-coated-bare-metal-stent-system-in-native-coronary-stenosis%C3%A3-the-axetis-fim-trial
#20
Taku Asano, Pannipa Suwannasom, Yuki Katagiri, Yosuke Miyazaki, Yohei Sotomi, Robin P Kraak, Joanna Wykrzykowska, Benno J Rensing, Jan J Piek, Mariann Gyöngyösi, Patrick W Serruys, Yoshinobu Onuma
BACKGROUND: A novel bare metal stent with an SiO2coating was developed to prevent excessive neointimal hyperplasia by inertization of the metallic stent surface. The efficacy of the device was demonstrated in a preclinical model. The aim of this first-in-man trial was to assess the safety and feasibility of the new device.Methods and Results:This prospective non-randomized single-arm trial was designed to enroll 35 patients with a de novo coronary lesion. Quantitative coronary angiography and optical coherence tomography (OCT) were performed at the baseline procedure and at the 6-month follow-up...
July 14, 2017: Circulation Journal: Official Journal of the Japanese Circulation Society
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