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Journals Clinical Physiology and Functi...

Clinical Physiology and Functional Imaging

https://read.qxmd.com/read/37839043/tilt-table-testing-methodology-and-practical-insights-for-the-clinic
#21
REVIEW
Steven van Zanten, Richard Sutton, Viktor Hamrefors, Artur Fedorowski, Frederik J de Lange
Tilt table testing (TTT) has been used for decades to study short-term blood pressure (BP) and heart rate regulation during orthostatic challenges. TTT provokes vasovagal reflex in many syncope patients as a background of widespread use. Despite the availability of evidence-based practice syncope guidelines, proper application and interpretation of TTT in the day-to-day care of syncope patients remain challenging. In this review, we offer practical information on what is needed to perform TTT, how results should be interpreted including the Vasovagal Syncope International Study classification, why syncope induction on TTT is necessary in patients with unexplained syncope and on indications for TTT in syncope patient care...
October 15, 2023: Clinical Physiology and Functional Imaging
https://read.qxmd.com/read/37830144/agreement-between-self-reported-and-objectively-assessed-physical-activity-among-out-of-hospital-cardiac-arrest-survivors
#22
JOURNAL ARTICLE
Katarina Heimburg, Gisela Lilja, Erik Blennow Nordström, Hans Friberg, Lisa Gregersen Oestergaard, Anders M Grejs, Thomas R Keeble, Marco Mion, Niklas Nielsen, Christian Rylander, Magnus Segerström, Ida Katrine Thomsen, Susann Ullén, Johan Undén, Matthew P Wise, Tobias Cronberg, Åsa B Tornberg
BACKGROUND: Low level of physical activity is a risk factor for new cardiac events in out-of-hospital cardiac arrest (OHCA) survivors. Physical activity can be assessed by self-reporting or objectively by accelerometery. AIM: To investigate the agreement between self-reported and objectively assessed physical activity among OHCA survivors HYPOTHESIS: Self-reported levels of physical activity will show moderate agreement with objectively assessed levels of physical activity...
October 13, 2023: Clinical Physiology and Functional Imaging
https://read.qxmd.com/read/37795627/switch-to-gliflozins-and-biventricular-function-improvement-in-patients-with-chronic-heart-failure-and-diabetes-mellitus
#23
JOURNAL ARTICLE
Michele Correale, Pietro Mazzeo, Martino Fortunato, Matteo Paradiso, Andrea Furore, Angela Ilaria Fanizzi, Lucia Tricarico, Giuseppe Pastore, Simona Alfieri, Natale Daniele Brunetti, Olga Lamacchia
BACKGROUND: SGLT2 inhibitors have been shown to reduce hospitalization in patients with chronic heart failure (CHF). The cardioprotective mechanisms of gliflozins however have not been fully elucidated. Aim of this study was therefore to evaluate the effect of SGLT2 inhibitors on right and left ventricular function in patients with diabetes and HF. METHODS: Seventy-eight patients with diabetes and CHF were enrolled in the study and followed up; 38 started treatment with SGLT2i, while the remaining 40 continued their previous antidiabetic therapy...
October 5, 2023: Clinical Physiology and Functional Imaging
https://read.qxmd.com/read/37789639/age-related-changes-in-muscle-thickness-echo-intensity-and-shear-modulus-of-the-iliocapsularis
#24
JOURNAL ARTICLE
Haruka Sakata, Hiroshige Tateuchi, Masahide Yagi, Kotono Kobayashi, Noriaki Ichihashi
PURPOSE: This study aimed to clarify age-related changes in the iliocapsularis (IC) using indicators of quantity, quality, and mechanical properties. We also compared the age-related changes in the IC and other hip muscles. METHODS: Eighty-seven healthy women (ages: 21-82 years, mean age: 45.9±15.7 years) participated in the experiment. We measured thickness, echo intensity, and shear modulus of the IC, iliacus muscle, rectus femoris, and the thickness and shear modulus of the hip joint capsule...
October 3, 2023: Clinical Physiology and Functional Imaging
https://read.qxmd.com/read/37642142/quantitative-myocardial-perfusion-should-be-interpreted-in-the-light-of-sex-and-comorbidities-in-patients-with-suspected-chronic-coronary-syndrome-a-cardiac-positron-emission-tomography-study
#25
JOURNAL ARTICLE
Anna Székely, Katarina Steding-Ehrenborg, Daniel Ryd, Fredrik Hedeer, Kristian Valind, Shahnaz Akil, Cecilia Hindorf, Erik Hedström, David Erlinge, Håkan Arheden, Henrik Engblom
Diagnosis and treatment of patients with suspected chronic coronary syndrome (CCS) currently relies on the degree of coronary artery stenosis and its significance for myocardial perfusion. However, myocardial perfusion can be affected by factors other than coronary stenosis. The aim of this study was to investigate to what extent sex, age, diabetes, hypertension and smoking affect quantitative myocardial perfusion, beyond the degree of coronary artery stenosis, in patients with suspected or established CCS...
August 29, 2023: Clinical Physiology and Functional Imaging
https://read.qxmd.com/read/37592454/first-clinical-experience-of-a-ring-configured-cadmium-zinc-telluride-camera-a-comparative-study-versus-conventional-gamma-camera-systems
#26
JOURNAL ARTICLE
Irma Cerić Andelius, David Minarik, Eva Persson, Henrik Mosén, Kristian Valind, Elin Trägårdh, Jenny Oddstig
BACKGROUND: A novel semiconductor cadmium zinc telluride (CZT) gamma camera system using a block sequential regularized expectation maximization (BSREM) reconstruction algorithm is now clinically available. Here we investigate how a multi-purpose ring-configurated CZT system can be safely applied in clinics and describe the initial optimization process. METHOD: Seventy-six patients (bone-, cardiac- and lung scan) were scanned on a conventional gamma camera (planar and/or single-photon emission computed tomography [SPECT]/SPECT-CT) used in clinical routine and on the ring-configurated CZT camera Starguide (GE Healthcare)...
August 17, 2023: Clinical Physiology and Functional Imaging
https://read.qxmd.com/read/37577825/effect-of-blood-flow-restriction-with-low-load-exercise-on-muscle-damage-in-healthy-adults-a-systematic-review-of-randomized-controlled-trials
#27
REVIEW
Jinchao Yang, Fenghao Ma, Qian Wang, Yuanfen Cui, Jun Zheng
INTRODUCTION: Blood flow restriction (BFR) is a relatively new rehabilitative technique and low-load exercise combined with BFR (LL-BFR) can increase muscle strength and muscle mass. However, it is currently unknown whether LL-BFR causes muscle damage. Therefore, the aim of this study is to investigate the effects of LL-BFR on muscle damage and provide recommendations for sports training and physical exercise. MATERIALS AND METHODS: A systematic search was conducted using PubMed, Web of Science, Medline, Cochrane Library and Physiotherapy Evidence Database (PEDro) with a cut-off of March 2022...
August 14, 2023: Clinical Physiology and Functional Imaging
https://read.qxmd.com/read/37501554/a-retrospective-head-to-head-comparison-of-the-lugano-classification-and-percist-for-fdg-pet-ct-response-assessment-in-diffuse-large-b-cell-lymphoma
#28
JOURNAL ARTICLE
Nicklas B Nielsen, Oke Gerke, Anne L Nielsen, Karen Juul-Jensen, Thomas S Larsen, Michael B Møller, Malene G Hildebrandt
BACKGROUND: Diffuse large B-cell lymphoma (DLBCL) is the most common form of lymphoma. European guidelines recommend FDG-PET/CT for staging and end of treatment (EOT) response assessment, mid-treatment response assessment is optional. We compared the Lugano Classification and PET Response Criteria In Solid Tumors (PERCIST) for FDG-PET/CT response assessment in DLBCL head-to-head. METHODS: We retrospectively included patients with DLBCL who underwent first-line R-CHOP(-like) therapy (2013-2020)...
July 27, 2023: Clinical Physiology and Functional Imaging
https://read.qxmd.com/read/37458374/heart-rate-stability-in-a-clinical-setting-and-after-a-short-exercise-in-healthy-male-volunteers
#29
JOURNAL ARTICLE
Fleur W H Wildenbeest, Gert-Jan Hassing, Michiel J B Kemme, Matthijs Moerland, Pim Gal
INTRODUCTION: Limited data exists on heart rate stabilization in the domiciled nature of phase I clinical studies, particularly when frequent measurements of QT intervals are involved. The present analysis aimed to evaluate heart rate stability in the domiciled nature of, and stabilization after a short exercise. METHODS: 56 healthy male subjects were included in this analysis. Data during a domiciled clinical setting and after a short exercise were analyzed. Mean values of 30 second intervals of collected electrocardiographical data (PR, RR, QT and QTcF intervals) during a 10-minute supine resting period in a domiciled nature or after walking up and down three stories (100 steps) were compared to baseline values using paired t-tests or compared to the intrasubject standard deviation...
July 17, 2023: Clinical Physiology and Functional Imaging
https://read.qxmd.com/read/37455250/association-between-abdominal-muscle-stiffness-diaphragm-thickness-and-peak-expiratory-flow-in-younger-versus-older-adults
#30
JOURNAL ARTICLE
Youngeun Lim, Yerim Do, Haneul Lee
The present study aimed to evaluate forced expiration based on transverse abdominis (TrA) stiffness by identifying the relationship between TrA stiffness and peak expiratory flow (PEF) in both younger and older adults. We also assessed the relationship between diaphragm thickness and PEF. A total of 31 younger (21.24 ± 2.73 years) and 34 older (71.35 ± 5.26 years) adults were included in the present study. TrA muscle stiffness was measured at rest and during abdominal bracing using shear wave elastography...
July 16, 2023: Clinical Physiology and Functional Imaging
https://read.qxmd.com/read/37455246/young-type-1-diabetes-subjects-sway-more-than-healthy-persons-when-somatosensory-system-is-challenged-in-static-standing-postural-stability-tests
#31
JOURNAL ARTICLE
Kim J Lesch, Vesa V Hyrylä, Timo Eronen, Saana Kupari, Lauri Stenroth, Mika Venojärvi, Mika P Tarvainen, Heikki O Tikkanen
In type 1 diabetes, it is important to prevent diabetes-related complications and postural instability may be one clinically observable manifestation early on. This study was set to investigate differences between type 1 diabetics and healthy controls in variables of instrumented posturography assessment to inform about the potential of the assessment in early detection of diabetes-related complications. Eighteen type 1 diabetics with no apparent complications (HbA1c = 58 ± 9 mmol/l, diabetes duration = 15 ± 7 years) and 35 healthy controls underwent six one-minute two feet standing postural stability tests on a force plate...
July 16, 2023: Clinical Physiology and Functional Imaging
https://read.qxmd.com/read/37421336/lobar-quantification-of-pulmonary-perfusion-prior-to-minimally-invasive-lung-reduction-improves-prediction-of-post-procedure-outcomes-a-pilot-study
#32
JOURNAL ARTICLE
Kritika Subramanian, Brett Muench, Eugene Shostak, Amanda Coffey, Lady Sawoszczyk, Fei Gao, Adam Leep, Ramya Rajaram, John Hornung, Elisabeth O'Dwyer
BACKGROUND: Endobronchial valve placement is a minimally invasive option for treatment of patients with severe emphysema, by reducing lung volumes in lobes with both poor ventilation and perfusion; ventilation is determined by emphysematous scores and perfusion by quantitative lung perfusion imaging. CT-based fissure identifying artificial intelligence algorithms have recently demonstrated enhanced quantification of the perfusion in a 5-lobar analysis. We hypothesized that this newly developed algorithm may offer greater utility in determining target treatment lobes by supplementing the radiographic risk stratification initiated by the conventional emphysematous scores alone...
July 8, 2023: Clinical Physiology and Functional Imaging
https://read.qxmd.com/read/37421321/cardiac-morbidity-and-the-cause-of-death-in-elderly-patients-with-prostate-cancer-and-incidental-cardiac-uptake-on-bone-scintigraphy
#33
JOURNAL ARTICLE
Eero Juntunen, Olli Suomalainen, Sorjo Mätzke, Tiina Heliö, Antti Loimaala, Valtteri Uusitalo
Cardiac transthyretin amyloidosis (ATTR) is a possible incidental finding on bone scintigraphy imaged due to prostate cancer. We investigated its significance in 1426 elderly prostate cancer patients (>70 years) who underwent bone scintigraphy in three nuclear medicine departments in Finland. Patients with Perugini grade two or three uptakes were considered positive for cardiac uptake. Heart failure diagnoses and pacemaker implantations were collected from the hospital's records. Mortality data were gathered from the Finnish national statistical service (Statistics Finland)...
July 8, 2023: Clinical Physiology and Functional Imaging
https://read.qxmd.com/read/37395515/erratum
#34
JOURNAL ARTICLE
(no author information available yet)
In Valind, et al. (2023), estimated glomerular filtration rate (eGFR) values using the Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI) equation were incorrectly calculated. As a result of this, the regression equations presented in equations 1, 3, 5 and 7 were incorrect. In consequence, the resulting R2 values presented in Table 2 and graphical representations in Figure 2 and Figure 3 were also incorrect. This article is protected by copyright. All rights reserved.
July 3, 2023: Clinical Physiology and Functional Imaging
https://read.qxmd.com/read/37395325/regional-motion-of-the-av-plane-is-related-to-the-cardiac-anatomy-and-deformation-of-the-av-plane-data-from-the-hunt-study
#35
JOURNAL ARTICLE
Asbjørn Støylen, Harald E Mølmen, Håvard Dalen
The study examines global and regional systolic shortening of the left (LV) and right ventricle (RV) in 1266 individuals without evidence of heart disease in the third wave of the HUNT study. Regional mitral annular systolic displacement (MAPSE) was 1.5 cm in the septum and anterior walls, 1.6 cm in the lateral wall and 1.7 cm in the inferior wall, global mean 1.6 cm. Peak systolic velocity S' was 8.0, 8.3, 8.8 and 8.6 cm/s in the same walls (global mean 8.7 cm/s). All measures of LV longitudinal shortening correlated, mean MAPSE and S' also correlated with stroke volume (SV) and ejection fraction (EF)...
July 3, 2023: Clinical Physiology and Functional Imaging
https://read.qxmd.com/read/37332243/cerebrovascular-and-cardiovascular-responses-to-the-valsalva-manoeuvre-during-hyperthermia
#36
JOURNAL ARTICLE
Blake G Perry, Stephanie Korad, Toby Mündel
During hyperthermia the perturbations in mean arterial blood pressure (MAP) produced by the Valsalva manoeuvre (VM) are more severe. However, whether these more severe VM induced changes in MAP are translated to the cerebral circulation during hyperthermia is unclear. Healthy participants (n=12, 1 female, mean±SD: age 24±3 years) completed a 30 mm Hg (mouth pressure) VM for 15 s whilst supine during normothermia and mild hyperthermia. Hyperthermia was induced passively using a liquid conditioning garment with core temperature measured via ingested temperature sensor...
June 18, 2023: Clinical Physiology and Functional Imaging
https://read.qxmd.com/read/37317062/cardiorespiratory-fitness-components-in-relation-to-clinical-characteristics-disease-state-and-medication-intake-a-patient-registry-study
#37
JOURNAL ARTICLE
Nicholas Cauwenberghs, Josephine Sente, František Sabovčik, Evangelos Ntalianis, Kristofer Hedman, Jomme Claes, Kaatje Goetschalckx, Véronique Cornelissen, Tatiana Kuznetsova
BACKGROUND: Interpretation of cardiopulmonary exercise testing (CPET) results requires thorough understanding of test confounders such as anthropometrics, comorbidities and medication. Here, we comprehensively assessed the clinical determinants of cardiorespiratory fitness and its components in a heterogeneous patient sample. METHODS: We retrospectively collected medical and CPET data from 2320 patients (48.2% females) referred for cycle ergometry at the University Hospital Leuven, Belgium...
June 14, 2023: Clinical Physiology and Functional Imaging
https://read.qxmd.com/read/37300475/four-to-seven-year-follow-up-of-pharmacological-postconditioning-with-mangafodipir-as-an-adjunct-to-primary-pci-in-st-segment-elevation-myocardial-infarction
#38
JOURNAL ARTICLE
Walid El-Saadi, Jan Engvall, Jan-Erik Karlsson, Eva Maret
INTRODUCTION: Adverse left ventricular remodelling (AR) develops over time in approximately 30% of patients with a history of coronary artery disease. AR manifests as a structural change in the left ventricle (LV) in terms of increased volumes and reduced left ventricular ejection fraction (LVEF). Manganese dipyridoxyl diphosphate (mangafodipir) has demonstrated interesting cardioprotective features in acute myocardial ischaemia. Pharmacological postconditioning (PP) with mangafodipir as an adjunct to primary percutaneous coronary intervention may possibly reduce the development of AR over time in ST-elevation myocardial infarction (STEMI)...
June 10, 2023: Clinical Physiology and Functional Imaging
https://read.qxmd.com/read/37293922/end-tidal-oxygen-partial-pressure-is-a-strong-prognostic-predictive-factor-in-patients-with-cardiac-disease
#39
JOURNAL ARTICLE
Asami Ogura, Kazuhiro P Izawa, Hideto Tawa, Masaaki Wada, Masashi Kanai, Ikko Kubo, Ayano Makihara, Ryohei Yoshikawa, Yuichi Matsuda
BACKGROUND: Cardiopulmonary exercise testing (CPET) variables represent central and peripheral factors and combined factors in the pathology of patients with cardiac disease. The difference in end-tidal oxygen partial pressure from resting to anaerobic threshold (ΔPETO2 ) may represent predominantly peripheral factors. This study aimed to verify the prognostic significance of ΔPETO2 for major adverse cardiac and cerebrovascular events (MACCE) in cardiac patients, including comparison with the minute ventilation-carbon dioxide production relationship (VE/VCO2 slope), and peak oxygen uptake (VO2 )...
June 9, 2023: Clinical Physiology and Functional Imaging
https://read.qxmd.com/read/37293795/heart-rate-variability-and-haemodynamic-function-in-individuals-with-hypertrophic-cardiomyopathy
#40
JOURNAL ARTICLE
A I Alyahya, S J Charman, N C Okwose, A S Fuller, C Eggett, P Luke, K Bailey, G A MacGowan, D G Jakovljevic
OBJECTIVES: Heart rate variability (HRV) is a measure of cardiac autonomic function. This study: (1) evaluated the differences in HRV and haemodynamic function between individuals with hypertrophic cardiomyopathy (HCM) and healthy controls, and (2) determined the relationship between HRV and haemodynamic variables in individuals with HCM. METHODS: Twenty-eight individuals with HCM (n=7, females; age 54±15 years; body mass index: 29±5 kg/m2 ) and 28 matched healthy individuals (n=7 females; age 54±16 years; body mass index: 29±5 kg/m2 ) completed 5-minute HRV and haemodynamic measurements under resting (supine) conditions using bioimpedance technology...
June 9, 2023: Clinical Physiology and Functional Imaging
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