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Brachytherapy

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https://www.readbyqxmd.com/read/28697858/accelerated-partial-breast-irradiation-for-elderly-women-with-early-breast-cancer-a-compromise-between-whole-breast-irradiation-and-omission-of-radiotherapy
#1
Shakeel Sumodhee, Johan Levy, Emmanuel Chamorey, Daniel Lam Cham Kee, Marie-Eve Chand, Mathieu Gautier, Isabelle Peyrottes, Emmanuel Barranger, Jean-Michel Hannoun-Levi
PURPOSE: Regarding adjuvant radiation therapy making decision for elderly women, Albert (2013) published a nomogram predicting the mastectomy-free survival (MFS) rate with or without adjuvant irradiation. Based on this approach, we proposed to investigate the use of accelerated partial breast irradiation (APBI) vs. whole breast irradiation (WBI) or endocrine therapy alone in elderly low-risk breast cancer patients. METHODS AND MATERIALS: For each elderly woman treated by conserving surgery and APBI (multicatheter interstitial high-dose-rate brachytherapy), 5- and 10-year MFS rates were calculated...
July 8, 2017: Brachytherapy
https://www.readbyqxmd.com/read/28694117/brachytherapy-boost-for-prostate-cancer-a-potential-conflict-of-disinterest
#2
LETTER
Jean-Michel Hannoun-Levi, Arthur Hannoun
No abstract text is available yet for this article.
July 7, 2017: Brachytherapy
https://www.readbyqxmd.com/read/28694116/effect-of-bladder-distension-on-doses-to-organs-at-risk-in-pulsed-dose-rate-3d-image-guided-adaptive-brachytherapy-for-locally-advanced-cervical-cancer
#3
Jean Philippe Nesseler, Claire Charra-Brunaud, Julia Salleron, Jean François Py, Andres Huertas, Emilie Meknaci, Florent Courrech, Didier Peiffert, Sophie Renard-Oldrini
PURPOSE: To evaluate the impact of bladder distension on doses to organs at risk in patients treated with 3D image-guided adaptive pulsed-dose-rate (PDR) brachytherapy (BT) for locally advanced cervical cancer. METHODS AND MATERIALS: Twenty-two patients who had previously been treated by external beam radiation therapy (EBRT), underwent BT treatment planning to a pelvic MRI (or a CT scan in case of contraindication) after their bladder was filled with 100 cc of physiological saline (full bladder)...
July 7, 2017: Brachytherapy
https://www.readbyqxmd.com/read/28694115/differences-in-urethral-dosimetry-between-ct-and-mr-imaging-in-multichannel-vaginal-cylinder-brachytherapy
#4
Katherine S Chen, Scott M Glaser, Hayeon Kim, Sushil Beriwal
PURPOSE: In image-based brachytherapy (IBBT), the dosimetry of small structures may be particularly sensitive to changes in contouring between imaging modalities. We therefore sought to characterize differences in urethral dosimetry in vaginal brachytherapy based on contouring on MRI vs. CT. METHODS AND MATERIALS: We retrospectively identified our most recent 15 patients treated with intracavitary brachytherapy for distal vaginal malignancies. On T2-weighted MRI, both the lumen and urethral wall were contoured...
July 7, 2017: Brachytherapy
https://www.readbyqxmd.com/read/28676428/american-brachytherapy-society-consensus-report-for-accelerated-partial-breast-irradiation-using-interstitial-multicatheter-brachytherapy
#5
REVIEW
Jaroslaw T Hepel, Douglas Arthur, Simona Shaitelman, Csaba Polgár, Dorin Todor, Imran Zoberi, Mitchell Kamrava, Tibor Major, Catheryn Yashar, David E Wazer
PURPOSE: To develop a consensus report for the quality practice of accelerated partial breast irradiation (APBI) using interstitial multicatheter brachytherapy (IMB). METHODS AND MATERIALS: The American Brachytherapy Society Board appointed an expert panel with clinical and research experience with breast brachytherapy to provide guidance for the current practice of IMB. This report is based on a comprehensive literature review with emphasis on randomized data and expertise of the panel...
July 1, 2017: Brachytherapy
https://www.readbyqxmd.com/read/28673762/diffusion-weighted-mri-in-image-guided-adaptive-brachytherapy-tumor-delineation-feasibility-study-and-comparison-with-gec-estro-guidelines
#6
Antoine Schernberg, Corinne Balleyguier, Isabelle Dumas, Sébastien Gouy, Alexandre Escande, Enrica Bentivegna, Philippe Morice, Eric Deutsch, Christine Haie-Meder, Cyrus Chargari
PURPOSE: To examine the feasibility of using diffusion-weighted images (DWIs) coregistered with T2-weighted (T2w) sequence in treatment planning system to improve target delineation for image-guided adaptive brachytherapy (IGABT) in locally advanced cervical cancer patients. METHODS AND MATERIALS: We retrospectively examined the records of consecutive patients who were referred to our institution for pulse-dose-rate IGABT between May and December 2015 after concurrent chemoradiation...
June 30, 2017: Brachytherapy
https://www.readbyqxmd.com/read/28669539/monte-carlo-dosimetric-characterization-of-the-flexisource-co-60-high-dose-rate-brachytherapy-source-using-penelope
#7
Julio F Almansa, Rafael Guerrero, Javier Torres, Antonio M Lallena
PURPOSE: (60)Co sources have been commercialized as an alternative to (192)Ir sources for high-dose-rate (HDR) brachytherapy. One of them is the Flexisource Co-60 HDR source manufactured by Elekta. The only available dosimetric characterization of this source is that of Vijande et al. [J Contemp Brachytherapy 2012; 4:34-44], whose results were not included in the AAPM/ESTRO consensus document. In that work, the dosimetric quantities were calculated as averages of the results obtained with the Geant4 and PENELOPE Monte Carlo (MC) codes, though for other sources, significant differences have been quoted between the values obtained with these two codes...
June 29, 2017: Brachytherapy
https://www.readbyqxmd.com/read/28648486/focal-brachytherapy-for-localized-prostate-cancer-urinary-toxicity-depends-on-tumor-location
#8
Victor Srougi, Eric Barret, Igor Nunes-Silva, Mohammed Baghdadi, Silvia Garcia-Barreras, Noelle Pierrat, Francois Rozet, Marc Galiano, Rafael Sanchez-Salas, Xavier Cathelineau, Jean-Marc Cosset
PURPOSE: To evaluate whether patients with prostate cancer have worse functional urinary recovery with focal brachytherapy (FBT) at the base versus the apex of the prostate. METHODS AND MATERIALS: The functional outcomes of patients treated with FBT at the base of the prostate were compared with those of patients treated with FBT at the apex. Urinary symptoms, continence, and erectile dysfunction were measured using the International Prostate Symptom Score (IPSS), International Continence Score (ICS), and International Index of Erectile Function (IIEF-5) questionnaires, respectively, at baseline and at 6, 12, and 24 months after treatment...
June 22, 2017: Brachytherapy
https://www.readbyqxmd.com/read/28642046/prostate-specific-antigen-percentage-an-early-predictive-tool-after-iodine-125-interstitial-brachytherapy-for-prostate-cancer
#9
Mauro Paoluzzi, Andrea Losa, Valentina Cerboneschi, Caterina Colosimo, Nicola Fontana, Paola Mangili, Marcello Mignogna, Luciano Nava, Valentina Ravaglia
BACKGROUND: After interstitial prostate iodine-125 brachytherapy (BT), prostate-specific antigen (PSA) evolution in time could predict overall biochemical relapse, but, considering the single patient, it is influenced by the presentation PSA amount and by the prostatic volume. It is also challenging to differentiate a PSA bounce from a biochemical relapse. PURPOSE: To determine the usefulness of PSA percentage (PP) defined as the rate between PSA presented by a patient at time "t" and the PSA that the same patient had presented at the time of diagnosis (t0) assumed as 100% in predicting biochemical relapse and in differentiating them from PSA Bounces...
June 19, 2017: Brachytherapy
https://www.readbyqxmd.com/read/28624329/the-bebig-valencia-type-skin-applicators-dosimetric-study-and-implementation-of-a-dosimetric-hybrid-technique
#10
Georgios Anagnostopoulos, Michael Andrássy, Dimos Baltas
PURPOSE: To determine the relative dose rate distribution in water for the Bebig 20 mm and 30 mm skin applicators and report results in a form suitable for potential clinical use. Results for both skin applicators are also provided in the form of a hybrid Task Group 43 (TG-43) dosimetry technique. Furthermore, the radiation leakage around both skin applicators from the radiation protection point of view and the impact of the geometrical source position uncertainties are studied and reported...
June 14, 2017: Brachytherapy
https://www.readbyqxmd.com/read/28623085/variability-of-treatment-planning-of-seed-implantation-a-japanese-multicenter-simulation-study
#11
Hiromichi Ishiyama, Masahiro Nakano, Kazuhito Toya, Ryuichi Kota, Koyo Kikuchi, Takahiro Yamaguchi, Naoaki Kono, Shogo Kawakami, Yuki Tsutsumi, Tomoki Tanaka, Takahisa Eriguchi, Saiji Ohga, Toshihiro Yamaguchi, Yoshiaki Takakawa, Masashi Morita, Norihisa Katayama, Toshio Ohashi, Manabu Aoki, Atsunori Yorozu, Siro Saito
PURPOSE: This multicenter study was conducted to evaluate the current variability of treatment planning of seed implantation in Japanese centers and the feasibility of two virtual trials. METHODS AND MATERIALS: Two types of contour data were sent to 12 radiation oncologists with a request letter that asked them to make treatment plans on the data in the same manner as in their own practice. Five of the 12 radiation oncologists were asked to participate in the two virtual trials in which the D90 (dose to the hottest 90% of prostate volume) was 1) required to be set at just 180 Gy and 2) increased as much as possible without violating other limitations...
June 13, 2017: Brachytherapy
https://www.readbyqxmd.com/read/28619385/rectum-and-bladder-spacing-in-cervical-cancer-brachytherapy-using-a-novel-injectable-hydrogel-compound
#12
Antonio L Damato, Megan Kassick, Akila N Viswanathan
PURPOSE: The aim of this study was to evaluate injection of a novel hydrogel (TraceIT; Augmenix, Waltham, MA) between the cervix, rectum, and bladder in female cadavers compared with, and in addition to, the current standard of gauze packing, for organ-at-risk sparing in cervical cancer brachytherapy planning. METHODS AND MATERIALS: This brachytherapy cadaver study used T2-weighted MRI and CT imaging to compare three scenarios: (1) gauze packing alone, (2) hydrogel injection placed in the cervical fornices and rectovaginal septum, and (3) gauze packing in conjunction with hydrogel injection...
June 12, 2017: Brachytherapy
https://www.readbyqxmd.com/read/28602708/reduced-toxicity-with-equivalent-outcomes-using-three-dimensional-volumetric-3dv-image-based-versus-nonvolumetric-point-based-nv-brachytherapy-in-a-cervical-cancer-population
#13
Kimberly M Thomas, Genevieve Maquilan, Strahinja Stojadinovic, Paul Medin, Michael R Folkert, Kevin Albuquerque
PURPOSE: Brachytherapy (BT) techniques have historically used a two-dimensional nonvolumetric (NV) system involving dose prescribed to a point fixed in space. We compared dosimetric, toxicity, and oncologic outcomes for volumetric planning (3DV) versus CT point-based planning. METHODS AND MATERIALS: Patients treated with external beam radiation therapy and high dose rate (HDR) intracavitary BT were included (n = 71). Patients planned with NV BT treated from 2009 to 2011 (n = 37) were compared to patients planned with 3DV BT treated from 2012 to 2014 (n = 34)...
June 8, 2017: Brachytherapy
https://www.readbyqxmd.com/read/28600140/income-generated-by-women-treated-with-magnetic-resonance-imaging-based-brachytherapy-a-simulation-study-evaluating-the-macroeconomic-benefits-of-implementing-a-high-end-technology-in-a-public-sector-healthcare-setting
#14
Santam Chakraborty, Umesh Mahantshetty, Supriya Chopra, Shirley Lewis, Vinod Hande, Shivakumar Gudi, Rahul Krishnatry, Reena Engineer, Shyam Kishore Shrivastava
PURPOSE: To estimate the difference in income generated if all women presenting in our institute over a 5-year period were treated with MRI-based image-guided brachytherapy (MR-IGBT) instead of conventional radiograph-based brachytherapy (CR-BT). METHODS AND MATERIALS: Outcome data from 463 patients (94 treated with MR-IGBT) treated in our institute was used to simulate cumulative women-days of work and cumulative income over 5 years for 5526 patients expected to be treated in this period...
June 6, 2017: Brachytherapy
https://www.readbyqxmd.com/read/28600139/change-of-target-volume-and-its-dosimetric-impact-during-the-course-of-accelerated-partial-breast-irradiation-using-intraoperative-multicatheter-interstitial-brachytherapy-after-open-cavity-surgery
#15
Ritu Raj Upreti, Ashwini Budrukkar, Udita Upreti, Shagun Misra, Tabassum Wadasadawala, Satish Kohle, Deepak D Deshpande
PURPOSE: To investigate the change of clinical target volume (CTV) and its dosimetric impact during the course of accelerated partial breast irradiation (APBI) using intraoperative multicatheter interstitial brachytherapy after open cavity surgery. METHODS AND MATERIALS: Twenty-two patients of APBI with intraoperative placement of catheters underwent computed tomography scans for the treatment planning before the first (CT1) and the last (CT2) treatment fraction...
June 6, 2017: Brachytherapy
https://www.readbyqxmd.com/read/28579419/the-effect-of-catheter-displacement-and-anatomical-variations-on-the-dose-distribution-in-mri-guided-focal-hdr-brachytherapy-for-prostate-cancer
#16
Metha Maenhout, Jochem R N van der Voort van Zyp, Maxence Borot de Battisti, Max Peters, Marco van Vulpen, Maurice van den Bosch, Marinus A Moerland
PURPOSE: The aim of this study was to analyze the effect of catheter displacement and anatomical variations of prostate and organs at risk on dose distribution in MRI-guided 19 Gy single fraction focal high-dose-rate brachytherapy (HDR-BT) of the prostate. METHODS AND MATERIALS: Seventeen patients with localized prostate cancer were enrolled in a prospective trial investigating focal HDR-BT in a 1.5 T MRI-HDR-BT facility. The diagnostic MRI delineations were registered with intraoperative MR scan, and a single fraction of 19 Gy was applied to the visible tumor...
June 1, 2017: Brachytherapy
https://www.readbyqxmd.com/read/28578920/clinical-factors-and-dosimetry-associated-with-the-development-of-prostate-brachytherapy-related-urethral-strictures-a-matched-case-control-study
#17
Sandeep Singhal, Muhammad F Jamaluddin, Emma Lee, Ronald S Sloboda, Matthew Parliament, Nawaid Usmani
PURPOSE: Urethral strictures are a rare complication of prostate brachytherapy (BXT), with prior studies showing radiation dose to the bulbomembranous urethra as being associated with stricture formation. This retrospective case-control study explored clinical and dosimetric parameters associated with the development of BXT-related urethral strictures. METHODS AND MATERIALS: A cohort of 34 patients developed urethral strictures after BXT at our institution for the period of 2008-2014...
May 31, 2017: Brachytherapy
https://www.readbyqxmd.com/read/28578919/opioid-consumption-and-pain-in-gynecological-cancer-patients-treated-with-interstitial-brachytherapy
#18
Lucas C Mendez, Stephen Choi, Laura D'Alimonte, Elizabeth Barnes, Lisa Barbera, Eric Leung
PURPOSE: Interstitial brachytherapy (ISBT) has advantages over the intracavitary techniques in the treatment of gynecological malignancies. The insertion of catheters into tumor enables higher dose conformality and normal tissue sparing. However ISBT can be associated with pain due its invasiveness. The goal of this study is to assess pain and opioid consumption of patients implanted with a perineal ISBT applicator. METHODS AND MATERIALS: Forty-eight patients were treated with ISBT from September 2014 to April 2016...
May 31, 2017: Brachytherapy
https://www.readbyqxmd.com/read/28576644/real-time-electromagnetic-tracking-based-treatment-platform-for-high-dose-rate-prostate-brachytherapy-clinical-workflows-and-end-to-end-validation
#19
Luc Beaulieu, Emmanuel Racine, Dae Yup Han, Eric Vigneault, I-Chow Hsu, J Adam M Cunha
PURPOSE: New technologies were integrated into a novel treatment platform combining electromagnetically (EM) tracked catheters, a 3D ultrasound (3DUS) imaging device, and a new treatment planning system to provide a real-time prostate high-dose-rate (HDR) brachytherapy treatment system. This work defines workflows for offline CT and online 3DUS planning scenarios and preclinical end-to-end validation of the platform. METHODS AND MATERIALS: The platform is composed of an EM-tracked stylet, a EM-tracked 3DUS probe, and an EM-tracked template guide, all used with the NDI Aurora field generator (NDI, Ontario, Canada)...
May 30, 2017: Brachytherapy
https://www.readbyqxmd.com/read/28552495/bending-the-slope-of-the-brachytherapy-curve-mri-assisted-radiosurgery-for-the-treatment-of-prostate-cancer
#20
EDITORIAL
Steven J Frank, Firas Mourtada
No abstract text is available yet for this article.
May 25, 2017: Brachytherapy
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