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Jingfei Ma, Marinus A Moerland, Aradhana M Venkatesan, Tharakeswara K Bathala, Rajat J Kudchadker, Kristy K Brock, Steven J Frank
PURPOSE: The purpose of this work is to present a brief review of MRI physics principles pertinent to prostate brachytherapy, and a summary of our experience in optimizing protocols for prostate brachytherapy applications. METHODS AND MATERIALS: We summarized essential MR imaging characteristics and their interplays that need to be considered for prostate brachytherapy applications. These include spatial resolution, signal-to-noise ratio, image contrast, artifacts, geometric distortion, specific absorption rate, and total scan time...
January 4, 2017: Brachytherapy
Waqar Haque, Vivek Verma, Anam Haque, E Brian Butler, Bin S Teh
PURPOSE: In 2009, the American Society for Radiation Oncology (ASTRO) published consensus recommendations that stated ductal carcinoma in situ (DCIS) patients were in a "cautionary" group for accelerated partial breast irradiation (APBI) and should not receive APBI outside of a clinical trial. However, very recently, ASTRO placed low-risk DCIS patients in the "suitable" category. Given this recent change, we aimed to use the Surveillance, Epidemiology, and End Results (SEER) database to evaluate past patterns of implantable APBI (IAPBI) utilization in women with DCIS...
January 4, 2017: Brachytherapy
Payal D Soni, Alejandro Berlin, Aradhana M Venkatesan, Patrick W McLaughlin
PURPOSE: To provide an MRI based functional anatomy guide to prostate brachytherapy. METHODS AND MATERIALS: We performed a narrative review of periprostatic functional anatomy and the significance of this anatomy in prostate brachytherapy treatment planning. RESULTS: MRI has improved delineation of gross tumor and critical periprostatic structures that have been implicated in toxicity. Furthermore, MRI has revealed the significant anatomic variants and the dynamic nature of these structures that can have significant implications for treatment planning and dosimetry...
December 28, 2016: Brachytherapy
Mark J Rivard
PURPOSE: A brachytherapy (BT) device has been developed with shielding to provide directional BT for preferentially irradiating malignancies while sparing healthy tissues. The CivaSheet is a flexible low-dose-rate BT device containing CivaDots with (103)Pd shielded by a thin Au disk. This is the first report of a clinical dosimetric characterization of the CivaSheet device. METHODS AND MATERIALS: Radiation dose distributions near a CivaDot were estimated using the MCNP6 radiation transport code...
December 27, 2016: Brachytherapy
J D Gruhl, D Zheng, J L Longo, C Enke, A O Wahl
PURPOSE: The aim of this study was to compare the organ-at-risk doses to the rectum and the bladder in postoperative endometrial cancer patients who receive high-dose rate vaginal brachytherapy (HDR-VB), when using three different methods of treatment planning: (Workflow A) individualized treatment planning before every fraction, (Workflow B) individualized treatment planning for first fraction only), and (Workflow C) using a template plan based on applicator choice and prescription specifics without patient-specific imaging or planning (standardized template approach)...
December 27, 2016: Brachytherapy
Stephen Doggett, Shigeru Chino, Todd Lempert, Jay Federhart
PURPOSE: Tracheal and paratracheal malignancies present challenges in radiotherapeutic management due to their proximity to sensitive structures, central location, and because of the potential for catastrophic radiation induced fistula. The use of external beam radiation therapy and intraluminal brachytherapy has a limited number of reports in the literature. We have searched for a technique for treating tracheal and paratracheal malignancies allowing application of a high dose of radiation while minimizing dose to normal tissues...
December 27, 2016: Brachytherapy
V Atallah, N Leduc, M Creoff, P Sargos, T Taouil, P Escarmant, V Vinh-Hung
PURPOSE: Prostate cancer is the most frequent malignancy in African-Caribbean men, a population sharing common genetic traits with African-American (AA) but presenting also genomic and epidemiologic specificities. Despite socioeconomic disparities with French mainland, all patients were treated within the French state-financed equal-access health care system. In this study, we report biochemical outcomes of patients treated by brachytherapy in our department from 2005 to 2014 in an African-Caribbean population...
December 23, 2016: Brachytherapy
Wee Loon Ong, Bronwyn Matheson, Jeremy Millar
PURPOSE: To evaluate the incidence of acute urinary toxicity after permanent seed prostate brachytherapy (BT) over a 15-year period. METHODS AND MATERIALS: The study consisted of 782 prostate cancer patients treated with BT. All patients completed self-administered International Prostate Symptoms Score (IPSS) at baseline and during regular follow-up. We evaluated the risk of acute urinary retention (AUR) up to 3 months post-BT and lower urinary tract symptom (LUTS) resolution (defined as return to within two points of baseline IPSS score) at regular intervals, up to 24 months post-BT...
December 21, 2016: Brachytherapy
Fang Wang, Qiuying Tang, Guoxiao Lv, Feng Zhao, Xue Jiang, Xinli Zhu, Xinke Li, Senxiang Yan
PURPOSE: The aim of this overview was to assess the accuracy of computed tomography (CT)-based imaging technology and to compare it with magnetic resonance imaging (MRI) for the treatment planning of high-dose rate brachytherapy in cervical cancer. METHODS AND MATERIALS: A systematic search in PubMed, Embase, and the Cochrane Central was performed to identify clinical studies involving brachytherapy of cervical cancer and published before February 1, 2016. Outcomes of interest were geometric dimensions, dose parameters, and clinical results...
December 10, 2016: Brachytherapy
Shyamal Patel, D Jeffrey Demanes, Omar Ragab, Mingle Zhang, Darlene Veruttipong, Kristine Nguyen, Sang-June Park, Leonard Marks, Allan Pantuck, Michael Steinberg, Mitchell Kamrava
PURPOSE: Outcomes using high-dose-rate (HDR) brachytherapy monotherapy (without androgen deprivation therapy or external beam radiation therapy) for National Comprehensive Cancer Network-defined intermediate-risk (IR) patients are limited. We report our long-term data using HDR monotherapy for this patient population. METHODS AND MATERIALS: One-hundred ninety IR prostate cancer patients were treated 1996-2013 with HDR monotherapy. Biochemical prostate-specific antigen (PSA) failure was per the Phoenix definition...
December 10, 2016: Brachytherapy
Emma-Louise Jones, Anna Tonino Baldion, Christopher Thomas, Tom Burrows, Nick Byrne, Victoria Newton, Sarah Aldridge
PURPOSE: Custom-made surface mold applicators often allow more flexibility when carrying out skin brachytherapy, particularly for small treatment areas with high surface obliquity. They can, however, be difficult to manufacture, particularly if there is a lack of experience in superficial high-dose rate brachytherapy techniques or with limited resources. METHODS AND MATERIALS: We present a novel method of manufacturing superficial brachytherapy applicators utilizing three-dimensional (3D)-printing techniques...
December 10, 2016: Brachytherapy
György Kovács, Klaudia Müller, Tamer Soror, Corinna Melchert, Xiyuan Guo, Dieter Jocham, Axel Merseburger
PURPOSE: Clinical results of a biologic information-based focused dose escalation combined with dose de-escalation for the whole organ in external beam radiotherapy + high-dose-rate brachytherapy (HDR-BT) boost application for localized prostate cancer in a consecutively treated patient cohort. METHODS AND MATERIALS: One hundred thirty patients were treated with external beam radiotherapy (50 Gy) complementary to two multiparametric transrectal ultrasound-guided 15 Gy HDR-BT fractions...
December 7, 2016: Brachytherapy
Brian J Davis, Al V Taira, Paul L Nguyen, Dean G Assimos, Anthony V D'Amico, Alexander R Gottschalk, Gary S Gustafson, Sameer R Keole, Stanley L Liauw, Shane Lloyd, Patrick W McLaughlin, Benjamin Movsas, Bradley R Prestidge, Timothy N Showalter, Neha Vapiwala
PURPOSE: To provide updated American College of Radiology (ACR) appropriateness criteria for transrectal ultrasound-guided transperineal interstitial permanent source brachytherapy. METHODS AND MATERIALS: The ACR appropriateness criteria are evidence-based guidelines for specific clinical conditions that are reviewed every 3 years by a multidisciplinary expert panel. The guideline development and review include an extensive analysis of current medical literature from peer reviewed journals and the application of a well-established consensus methodology (modified Delphi) to rate the appropriateness of imaging and treatment procedures by the panel...
December 7, 2016: Brachytherapy
Gita Suneja, Derek Brown, Amy Chang, Beth Erickson, Elena Fidarova, Surbhi Grover, Umesh Mahantshetty, Subir Nag, Kailash Narayan, Memory Bvochora-Nsingo, Celia Viegas, Akila N Viswanathan, Ming Yin Lin, David Gaffney
PURPOSE: Most cervix cancer cases occur in low-income and middle-income countries (LMIC), and outcomes are suboptimal, even for early stage disease. Brachytherapy plays a central role in the treatment paradigm, improving both local control and overall survival. The American Brachytherapy Society (ABS) aims to provide guidelines for brachytherapy delivery in resource-limited settings. METHODS AND MATERIALS: A panel of clinicians and physicists with expertise in brachytherapy administration in LMIC was convened...
December 2, 2016: Brachytherapy
A Gomez-Iturriaga, F Casquero, J I Lopez, A Urresola, A Ezquerro, D Buscher, P Bilbao, J Crook
PURPOSE: Multiparametric MRI (mpMRI) has a potential role for the identification of aggressive cancer that can be targeted for biopsy. We report the incidence and severity of discordant information between the pathology found on the transrectal ultrasound (TRUS)-guided biopsy and the mpMRI findings in patients with favorable or intermediate-risk prostate cancer referred for brachytherapy. METHODS AND MATERIALS: From March 2014 to September 2015, 10/44 consecutive patients with low- or intermediate-risk prostate cancer referred for brachytherapy presented an aggressive lesion on mpMRI and underwent an MRI-TRUS fusion-guided transperineal biopsy of the index lesion...
December 2, 2016: Brachytherapy
Amandeep S Taggar, Tien Phan, Laurel Traptow, Robyn Banerjee, Corinne M Doll
PURPOSE: Brachytherapy (BT) techniques for cervical cancer in Canada have changed over the last decade, with evolution to high-dose-rate and image-guided BT. However, there are currently no national data on the use of interstitial BT (IBT). The purpose of this study was to document IBT utilization in Canadian centers, as well as update details of cervical cancer BT practices. METHODS AND MATERIALS: All Canadian centers with gynecologic BT services (n = 33) were identified, and one gynecology radiation oncologist per center was sent a 33-item e-mail questionnaire regarding their center's practice for cervical cancer BT in 2015...
November 30, 2016: Brachytherapy
Anna O Likhacheva, Phillip M Devlin, Shervin M Shirvani, Christopher A Barker, Phillip Beron, Ajay Bhatnagar, Stephen W Doggett, Lawrence Hochman, Charles Hsu, Michael Kasper, Martin Keisch, Subhakar Mutyala, Bradley Prestidge, Silvia Rodriguez Villalba, Vershalee Shukla, Srinath Sundararaman, Mitchell Kamrava
PURPOSE: The aim of this study was to define current patterns of care among radiation oncologists who use skin surface brachytherapy for the treatment of cutaneous squamous cell carcinoma (cSCC) and basal cell carcinoma (BCC) in academic and community settings. METHODS AND MATERIALS: A 30-question electronic survey was administered to clinician members of the American Brachytherapy Society. The respondents were asked to provide details regarding their clinical practice and their approach to skin surface brachytherapy...
November 28, 2016: Brachytherapy
Borut Kragelj, Jernej Zlatic, Lijana Zaletel-Kragelj
PURPOSE: To elucidate potential risk factors important for the appearance of late rectal toxicity (LRT) after high-dose-rate boost treatment (HDRBT) of prostate cancer and to validate the predictive value of the minimal dose to the most exposed 2 cc of rectum received with HDRBT (D2ccrect). METHODS AND MATERIALS: The study of LRT, defined as relative deterioration of defecation problems (RDDP) (stool frequency, pain, rectal bleeding, fecal urgency, and incontinence) during follow-up period, was carried out on 88 patients, consecutively treated from October 2006 through April 2011 with HDRBT of 3 × 6-7 Gy to 50-50...
November 28, 2016: Brachytherapy
Umesh Mahantshetty, Pushpa Naga, Reena Engineer, Supriya Sastri, Yogesh Ghadi, Udita Upreti, Vijaya Somesan, Sudarshan Kadam, Satish Kohle, Deepak Deshpande, Shyam Kishore Shrivastava
PURPOSE: With an aim to evaluate and report high dose date interstitial brachytherapy (HDR-ISBT) in vulvar cancers, we undertook this retrospective analysis. METHODS AND MATERIALS: Histologically proven vulvar cancers treated with HDR-ISBT between 2001 and 2016 were analyzed. Radiotherapy details, clinical outcome in terms of local control rates, survivals, and toxicities were evaluated. RESULTS: A total of 38 patients received HDR-ISBT, with definitive radiation in 29 (76...
November 19, 2016: Brachytherapy
Youngkyong Kim, Yeon-Joo Kim, Joo-Young Kim, Young Kyung Lim, Chiyoung Jeong, Jonghwi Jeong, Meyoung Kim, Myong Cheol Lim, Sang-Soo Seo, Sang-Yoon Park
PURPOSE: To analyze the toxicities and dose-volume histogram parameters of external-beam and magnetic resonance imaging-based intracavitary brachytherapy in cervical cancer patients. METHODS AND MATERIALS: Acute and late toxicities were assessed in 135 patients divided into four groups: group 1, grade 0; group 2, grades 1-4; group 3, grades 0-1; and group 4, grades 2-4. The doses at the International Commission on Radiation Units and Measurements (DICRU) and minimum doses to the most exposed 0...
November 18, 2016: Brachytherapy
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