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Brachytherapy

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https://www.readbyqxmd.com/read/29331575/validation-of-mri-to-trus-registration-for-high-dose-rate-prostate-brachytherapy
#1
Eric Poulin, Karim Boudam, Csaba Pinter, Samuel Kadoury, Andras Lasso, Gabor Fichtinger, Cynthia Ménard
PURPOSE: The objective of this study was to develop and validate an open-source module for MRI to transrectal ultrasound (TRUS) registration to support tumor-targeted prostate brachytherapy. METHODS AND MATERIALS: In this study, 15 patients with prostate cancer lesions visible on multiparametric MRI were selected for the validation. T2-weighted images with 1-mm isotropic voxel size and diffusion weighted images were acquired on a 1.5T Siemens imager. Three-dimensional (3D) TRUS images with 0...
January 10, 2018: Brachytherapy
https://www.readbyqxmd.com/read/29331574/a-medicare-cost-analysis-of-mri-versus-ct-based-high-dose-rate-brachytherapy-of-the-cervix-can-mri-based-planning-be-less-costly
#2
Amishi Bajaj, Grant Harmon, John Weaver, Brendan Martin, Michael Mysz, Murat Surucu, John C Roeske, Andre A Konski, William Small, Matthew M Harkenrider
PURPOSE: While some institutions deliver multiple fractions per implant for MRI-based planning, it is common for only one fraction to be delivered per implant with CT-based cervical brachytherapy. The purpose of this study was to compare physician costs, hospital costs, and overall costs for cervical cancer patients treated with either CT-based or MRI-based high-dose-rate (HDR) cervical brachytherapy to determine if MRI-based brachytherapy as described can be financially feasible. METHODS AND MATERIALS: We identified 40 consecutive patients treated with curative intent cervical brachytherapy...
January 10, 2018: Brachytherapy
https://www.readbyqxmd.com/read/29331573/deformable-image-registration-based-contour-propagation-yields-clinically-acceptable-plans-for-mri-based-cervical-cancer-brachytherapy-planning
#3
Christina Hunter Chapman, Daniel Polan, Karen Vineberg, Shruti Jolly, Katherine E Maturen, Kristy K Brock, Joann I Prisciandaro
PURPOSE: To study the dosimetric impact of deformable image registration-based contour propagation on MRI-based cervical cancer brachytherapy planning. METHODS AND MATERIALS: High-risk clinical target volume (HRCTV) and organ-at-risk (OAR) contours were delineated on MR images of 10 patients who underwent ring and tandem brachytherapy. A second set of contours were propagated using a commercially available deformable registration algorithm. "Manual-contour" and "propagated-contour" plans were optimized to achieve a maximum dose to the most minimally exposed 90% of the volume (D90) (%) of 6 Gy/fraction, respecting minimum dose to the most exposed 2cc of the volume (D2cc) OAR constraints of 5...
January 10, 2018: Brachytherapy
https://www.readbyqxmd.com/read/29331572/comments-on-low-dose-rate-prostate-brachytherapy-4-8-week-postimplant-prostate-specific-antigen-a-novel-predictor-of-biochemical-failure-free-survival
#4
LETTER
Kamyar Mansori, Erfan Ayubi, Saeid Safiri
No abstract text is available yet for this article.
January 10, 2018: Brachytherapy
https://www.readbyqxmd.com/read/29306674/a-comparison-of-early-prostate-specific-antigen-decline-between-prostate-brachytherapy-and-different-fractionation-of-external-beam-radiation-impact-on-biochemical-failure
#5
Daniel Taussky, Stéphane Bedwani, Nissan Meissner, Jean-Paul Bahary, Carole Lambert, Maroie Barkati, Marie-Claude Beauchemin, Cynthia Ménard, Guila Delouya
PURPOSE: The aim of this study was to compare early prostate-specific antigen (PSA) decline patterns and PSA nadirs between low-dose-rate seed prostate brachytherapy (LDR-PB) and different fractionations of external beam radiotherapy (EBRT) and their predictive importance for biochemical failure (bF). METHODS AND MATERIALS: Patients with D'Amico low- or intermediate-risk prostate cancer who underwent a single-modality treatment without androgen deprivation were included in this study...
January 3, 2018: Brachytherapy
https://www.readbyqxmd.com/read/29305151/efficacy-and-the-toxicity-of-the-interstitial-high-dose-rate-brachytherapy-in-the-management-of-recurrent-keloids-5-year-outcomes
#6
Ping Jiang, Matthias Geenen, Frank-André Siebert, Julia Bertolini, Bjoern Poppe, Ulf Luetzen, Juergen Dunst, Daniel Druecke
PURPOSE: Recurring keloids are a clinical challenge. Interdisciplinary treatments are required in most cases. Owing to the wide variety of concepts, the optimal treatment regime remains unclear. Our clinic established a protocol of perioperative interstitial high-dose-rate brachytherapy with three fractions of 6 Gy and achieved an excellent 2-year local control rate of 94% (In search of the optimal treatment of keloids: Report of a series and a review of the literature). This report is an update on our long-term results of prospective study...
January 2, 2018: Brachytherapy
https://www.readbyqxmd.com/read/29275869/image-guided-interstitial-high-dose-rate-brachytherapy-for-locally-recurrent-uterine-cervical-cancer-a-single-institution-study
#7
Rei Umezawa, Naoya Murakami, Satoshi Nakamura, Akihisa Wakita, Hiroyuki Okamoto, Keisuke Tsuchida, Tairo Kashihara, Kazuma Kobayashi, Ken Harada, Kana Takahashi, Koji Inaba, Yoshinori Ito, Hiroshi Igaki, Koji Masui, Ken Yoshida, Keiichi Jingu, Nikolaos Tselis, Jun Itami
PURPOSE: The aim of this study was to investigate the efficacy and safety of image-guided high-dose-rate (HDR) interstitial brachytherapy (ISBT) for reirradiation of locally recurrent uterine cervical cancer. METHODS AND MATERIALS: Between 2008 and 2015, patients receiving reirradiation using HDR-ISBT for local gross recurrence of uterine cervical cancer after definitive or postoperative radiotherapy were analyzed retrospectively. The prescription doses per fraction ranged 2...
December 21, 2017: Brachytherapy
https://www.readbyqxmd.com/read/29275868/ruthenium-brachytherapy-for-uveal-melanomas-factors-affecting-the-development-of-radiation-complications
#8
Monica M Pagliara, Luca Tagliaferri, Luigi Azario, Jacopo Lenkowicz, Angela Lanza, Rosa Autorino, Carmela G Caputo, Maria A Gambacorta, Vincenzo Valentini, Maria A Blasi
PURPOSE: To investigate how treatment complications are related to dosimetric parameters after ruthenium-106 brachytherapy for uveal melanoma, in a large, clinically homogeneous population. METHODS AND MATERIALS: A retrospective review was performed to evaluate patients affected by small and medium size uveal melanoma, treated with ruthenium-106 brachytherapy from December 2006 to December 2014. We excluded tumors with posterior margin within 1 mm from the edge of the optic disc and foveola...
December 21, 2017: Brachytherapy
https://www.readbyqxmd.com/read/29275867/authors-response
#9
LETTER
Cameron M Callaghan
No abstract text is available yet for this article.
December 21, 2017: Brachytherapy
https://www.readbyqxmd.com/read/29275079/efficacy-and-safety-of-iodine-125-radioactive-seeds-brachytherapy-for-advanced-non-small-cell-lung-cancer-a-meta-analysis
#10
REVIEW
Wenchao Zhang, Jiawei Li, Ran Li, Ying Zhang, Mingyong Han, Wei Ma
PURPOSE: This meta-analysis was conducted to investigate the efficacy and safety of 125I brachytherapy for locally advanced non-small cell lung cancer (NSCLC). METHODS AND MATERIALS: Trials comparing 125I brachytherapy with chemotherapy in NSCLC were identified. Meta-analysis was performed to obtain pooled risk ratios for an overall response rate (ORR), disease control rate (DCR) and complications, and pooled hazard ratio for overall survival (OS). RESULTS: Fifteen studies including 1188 cases were included...
December 20, 2017: Brachytherapy
https://www.readbyqxmd.com/read/29275078/cost-effectiveness-of-adjuvant-intravaginal-brachytherapy-in-high-intermediate-risk-endometrial-carcinoma
#11
John M Stahl, Shari Damast, Trevor J Bledsoe, Yi An, Vivek Verma, James B Yu, Melissa R Young, Nataniel H Lester-Coll
PURPOSE: We assessed the cost-effectiveness of adjuvant intravaginal brachytherapy (IVBT) vs. observation after total hysterectomy and bilateral salpingo-oophorectomy (TH/BSO) for high-intermediate risk (HIR) endometrial carcinoma. METHODS AND MATERIALS: A Markov model was used to assess the cost-effectiveness of IVBT by comparing average cumulative costs, quality-adjusted life years (QALYs), and incremental cost-effectiveness ratios (ICERs) between patients allocated to (1) 'observation' or (2) 'IVBT' after TH/BSO...
December 20, 2017: Brachytherapy
https://www.readbyqxmd.com/read/29269207/patient-reported-health-related-quality-of-life-for-men-treated-with-low-dose-rate-prostate-brachytherapy-as-monotherapy-with-125-iodine-103-palladium-or-131-cesium-results-of-a-prospective-phase-ii-study
#12
Pierre Blanchard, Thomas J Pugh, David A Swanson, Usama Mahmood, Hsiang-Chun Chen, Xuemei Wang, William J Graber, Rajat J Kudchadker, Teresa Bruno, Thomas Feeley, Steven J Frank
PURPOSE: To compare quality of life (QoL) after brachytherapy with one of the three approved radioactive isotopes. METHODS AND MATERIALS: Patients with mostly favorable intermediate-risk prostate cancer were treated on this prospective phase II trial with brachytherapy as monotherapy, without hormonal therapy. QoL was recorded at baseline and each follow-up by using the Expanded Prostate Cancer Index Composite instrument. The minimal clinically important difference was defined as half the standard deviation of the baseline score for each domain...
December 18, 2017: Brachytherapy
https://www.readbyqxmd.com/read/29254856/accelerated-partial-breast-irradiation-for-suitable-elderly-women-using-a-single-fraction-of-multicatheter-interstitial-high-dose-rate-brachytherapy-early-results-of-the-single-fraction-elderly-breast-irradiation-sifebi-phase-i-ii-trial
#13
Jean-Michel Hannoun-Lévi, Daniel Lam Cham Kee, Jocelyn Gal, Renaud Schiappa, Arthur Hannoun, Mathieu Gautier, Rabia Boulahssass, Isabelle Peyrottes, Emmanuel Barranger, Jean-Marc Ferrero, Marie-Eve Chand, Jérôme Doyen
PURPOSE/OBJECTIVE: To evaluate feasibility and early clinical outcomes of a single fraction of multi-catheter interstitial high-dose rate brachytherapy for accelerated partial breast irradiation (APBI) in the elderly. MATERIAL/METHODS: From November 2012 to September 2014, 26 patients (≥70) with early breast cancer were enrolled in a prospective phase II trial (NCT01727011). After lumpectomy, intra-operative catheter implant was performed for post-operative APBI (single fraction 16 Gy)...
December 15, 2017: Brachytherapy
https://www.readbyqxmd.com/read/29241706/placement-of-an-absorbable-rectal-hydrogel-spacer-in-patients-undergoing-low-dose-rate-brachytherapy-with-palladium-103
#14
Amandeep S Taggar, Tomer Charas, Gil'ad N Cohen, Keeratikarn Boonyawan, Marisa Kollmeier, Sean McBride, Nitin Mathur, Antonio L Damato, Michael J Zelefsky
PURPOSE: Rates of rectal toxicity after low-dose-rate (LDR) brachytherapy for prostate cancer are dependent on rectal dose, which is associated with rectal distance from prostate and implanted seeds. Placement of a hydrogel spacer between the prostate and rectum has proven to reduce the volume of the rectum exposed to higher radiation dose levels in the setting of external beam radiotherapy. We present our findings with placing a rectal hydrogel spacer in patients following LDR brachytherapy, and we further assess the impact of this placement on dosimetry and acute rectal toxicity...
December 11, 2017: Brachytherapy
https://www.readbyqxmd.com/read/29241705/characterizing-the-impact-of-adaptive-planning-on-image-guided-perineal-interstitial-brachytherapy-for-gynecologic-malignancies
#15
Adam Gladwish, Ananth Ravi, Lisa Barbera, Lucas Mendez, Melanie Davidson, Laura D'Alimonte, David D'Souza, Matt Wronski, Eric Leung
PURPOSE: To determine the dosimetric impact of organ and implant motion/deformation in the context of adaptive planning in image-guided gynecologic brachytherapy using a 3-fraction transperineal approach. METHODS AND MATERIALS: Twenty-six patients were analyzed. Each patient was treated with three fractions given over a 24-h period using a single insertion. A planning CT scan (±MRI) was acquired before the first fraction. A verification scan was taken within 1 h following the second fraction...
December 11, 2017: Brachytherapy
https://www.readbyqxmd.com/read/29241704/development-and-characterization-of-an-anthropomorphic-breast-phantom-for-permanent-breast-seed-implant-brachytherapy-credentialing
#16
Michael Roumeliotis, Sarah Quirk, Matthew Skarsgard, Tiana Trumpour, Elizabeth Watt, Tyler Meyer
PURPOSE: To develop an anthropomorphic breast phantom for use in credentialing of permanent breast seed implant brachytherapy. METHODS AND MATERIALS: A representative external contour and target volume was used as the basis of mold manufacturing for anthropomorphic breast phantom development. Both target and normal tissue were composed of gel-like materials that provide suitable computed tomography and ultrasound contrast for brachytherapy delivery. The phantoms were evaluated for consistency in construction (target location) and Hounsfield unit (computed tomography contrast)...
December 11, 2017: Brachytherapy
https://www.readbyqxmd.com/read/29229377/dosimetric-effects-of-saline-versus-water-filled-balloon-applicators-for-iort-using-the-model-s700-electronic-brachytherapy-source
#17
Gage Redler, Alistair Templeton, Heming Zhen, Julius Turian, Damian Bernard, James C H Chu, Katherine L Griem, Yixiang Liao
PURPOSE: The Xoft Axxent Electronic Brachytherapy System (Xoft, Inc., San Jose, CA) is a viable option for intraoperative radiation therapy (IORT) treatment of early-stage breast cancer. The low-energy (50-kVp) X-ray source simplifies shielding and increases relative biological effectiveness but increases dose distribution sensitivity to medium composition. Treatment planning systems typically assume homogenous water for brachytherapy dose calculations, including precalculated atlas plans for Xoft IORT...
December 8, 2017: Brachytherapy
https://www.readbyqxmd.com/read/29223507/limitations-in-learning-how-treatment-verifications-fail-and-what-to-do-about-it
#18
Susan Richardson, Bruce Thomadsen
PURPOSE: The purposes of this study were: to provide dialog on why classic incident learning systems have been insufficient for patient safety improvements, discuss failures in treatment verification, and to provide context to the reasons and lessons that can be learned from these failures. METHODS AND MATERIALS: Historically, incident learning in brachytherapy is performed via database mining which might include reading of event reports and incidents followed by incorporating verification procedures to prevent similar incidents...
December 6, 2017: Brachytherapy
https://www.readbyqxmd.com/read/29223506/treatment-planning-considerations-for-permanent-breast-seed-implant
#19
Amy Frederick, Tyler Meyer, Michael Roumeliotis
PURPOSE: To determine an optimal planning strategy for permanent breast seed implant that minimizes dose heterogeneity without degrading coverage and conformity. METHODS AND MATERIALS: A simple model was developed to investigate planning strategies incorporating a range of 103Pd seed activities, needle and seed spacings, and implants in which seed positions are either restricted to or permitted outside of spherical planning target volumes (PTVs). To address more realistic target geometries, model parameters were used to retrospectively replan a 10-patient cohort in MIM Symphony...
December 6, 2017: Brachytherapy
https://www.readbyqxmd.com/read/29203149/improved-rectal-dosimetry-with-the-use-of-spaceoar-during-high-dose-rate-brachytherapy
#20
Susan Y Wu, Lauren Boreta, Ashley Wu, Joey P Cheung, J Adam M Cunha, Katsuto Shinohara, Albert J Chang
PURPOSE: Hydrogel spacers have been suggested to limit rectal radiation dose with improvements in clinical outcomes in patients undergoing external beam radiation treatment for prostate cancer. No studies to date have assessed the utility and dosimetric effect of SpaceOAR (Augmenix, Inc, Waltham, MA), the only Food and Drug Administration-approved hydrogel rectal spacer, for high-dose-rate (HDR) brachytherapy. METHODS: Eighteen consecutive patients scheduled for HDR brachytherapy in the treatment of prostate cancer underwent transperineal ultrasound-guided placement of 10 cc of SpaceOAR hydrogel following catheter implantation...
December 1, 2017: Brachytherapy
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