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Brachytherapy

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https://www.readbyqxmd.com/read/29146103/assessment-of-the-implant-geometry-in-fractionated-interstitial-hdr-breast-brachytherapy-using-an-electromagnetic-tracking-system
#1
Markus Kellermeier, Rainer Fietkau, Vratislav Strnad, Christoph Bert
PURPOSE: During the partial-breast treatment course by interstitial brachytherapy, electromagnetic tracking (EMT) was applied to measure the implant geometry. Implant-geometry variation, choice of reference data, and three registration methods were assessed. METHODS AND MATERIALS: The implant geometry was measured in 28 patients after catheter implantation (EMTbed), during CT imaging (EMTCT), and in each of up to n = 9 treatment fractions (EMTF(k), k = 1, 2,… n)...
November 13, 2017: Brachytherapy
https://www.readbyqxmd.com/read/29146102/outcomes-by-molecular-subtype-after-accelerated-partial-breast-irradiation-using-single-entry-catheters
#2
Aman Saini, Robert Kuske, Coral Quiet, Cheri Pantoja, Daniel Reed, Victor Zannis
PURPOSE: Tumor biology is being recognized as an important indicator of prognosis and risk of locoregional recurrence. Here, we determine actuarial recurrence rates by approximated molecular subtype for women treated with single-entry catheter accelerated partial breast irradiation (sAPBI). METHODS AND MATERIALS: One thousand four hundred eighty-six women with invasive cancer having known ER, PR, and Her2 status and at least 1-year of followup were treated using MammoSite, Contura, or SAVI sAPBI from 2002 to 2014 at our institution...
November 13, 2017: Brachytherapy
https://www.readbyqxmd.com/read/29137956/pattern-of-relapse-and-dose-received-by-the-recurrent-intraprostatic-nodule-in-low-to-intermediate-risk-prostate-cancer-treated-with-single-fraction-19-gy-high-dose-rate-brachytherapy
#3
Lucas C Mendez, Ananth Ravi, Hans Chung, Chia-Lin Tseng, Matt Wronski, Moti Paudel, Merrylee McGuffin, Patrick Cheung, Andrew Loblaw, Gerard Morton
PURPOSE: The purposes of this study were to investigate the pattern of relapse in patients with low- or intermediate-risk prostate cancer treated with 19-Gy high-dose-rate brachytherapy (HDR-BT) and to calculate the dose received by the area of recurrence. METHODS AND MATERIALS: Patients included in this analysis were treated under a Phase II randomized trial that evaluated the role of 19-Gy HDR-BT monotherapy in low- and intermediate-risk prostate cancers. Multiparametric prostate MRI and prostate biopsy were performed in patients with suspicious local recurrence...
November 11, 2017: Brachytherapy
https://www.readbyqxmd.com/read/29128230/clinical-outcomes-using-image-guided-interstitial-brachytherapy-for-definitive-cervical-cancer-patients-with-high-risk-clinical-target-volumes-greater-than-30%C3%A2-cc
#4
Chenyang Wang, Jagdeep Raince, Uma Swamy, Sang-June Park, Lalaine Zaide, Shane Mesko, D Jeffrey Demanes, Mitchell Kamrava
PURPOSE: Given the limited data using an interstitial approach with 3D-based planning for definitive cervical cancer utilizing the GEC-ESTRO defined high-risk clinical target volume (HR-CTV), we reviewed our institutional experience of cervical cancer patients with HR-CTVs ≥ 30 cc to determine whether our clinical and toxicity outcomes are acceptable. METHODS: A retrospective review of 37 cervical cancer patients with high-risk clinical target volumes (HR-CTVs) ≥30 cc treated with interstitial image-guided brachytherapy (IS IGBT) was performed...
November 8, 2017: Brachytherapy
https://www.readbyqxmd.com/read/29113782/interobserver-variability-in-rectum-contouring-in-high-dose-rate-brachytherapy-for-prostate-cancer-a-multi-institutional-prospective-analysis
#5
Rodolfo Chicas-Sett, Francisco Celada-Alvarez, Susana Roldan, Silvia Rodriguez-Villalba, Miguel Santos-Olias, Pablo Soler-Catalan, Blanca Ibanez-Rosello, Leoncio Arribas, Alejandro Tormo, Jose M Benlloch, Jose Perez-Calatayud
PURPOSE: The aim of this study was to evaluate the interobserver variability (IOV) of rectum contouring, and its dosimetric consequences, for high-dose-rate brachytherapy in patients with prostate cancer across multiple institutions. METHODS AND MATERIALS: Five radiation oncologists contoured rectums in 10 patients on transperineal ultrasound image sets after establishing a delineation consensus. The D0.1cc, D1cc, and D2cc rectum volume parameters were determined...
November 4, 2017: Brachytherapy
https://www.readbyqxmd.com/read/29102741/physics-aspects-of-the-papillon-technique-five-decades-later
#6
Li Heng Liang, Nada Tomic, Te Vuong, Saad Aldelaijan, Hamed Bekerat, Francois DeBlois, Jan Seuntjens, Slobodan Devic
PURPOSE: The Papillon technique using 50-kVp soft X-rays to treat rectal adenocarcinomas was developed and clinically implemented in the 1960s. We describe differences between accurate dosimetry and clinical implementation of this technique that is extending from its very inception to date. METHODS AND MATERIALS: A renaissance of the Papillon technique occurred with two recently introduced 50-kVp systems: Papillon+ by Ariane and a custom-made rectal applicator (consisting of a surface applicator inserted into a proctoscope) by iCAD's Xoft Axxent Electronic Brachytherapy (eBT) System (iCad, Inc...
November 1, 2017: Brachytherapy
https://www.readbyqxmd.com/read/29102740/clinical-outcomes-with-mri-guided-image-based-brachytherapy-in-cervical-cancer-an-institutional-experience
#7
Vijai Simha, Bhavana Rai, Firuza D Patel, Rakesh Kapoor, Suresh C Sharma, Oinam A Singh, Veenu Singla, Bhaswanth Dhanireddy, Sushmita Ghoshal
PURPOSE: To evaluate the long-term disease control and toxicity to the organs at risk after dose-escalated image-based adaptive brachytherapy (BT) in cervical cancer. METHODS AND MATERIALS: Sixty patients of cervical cancer were treated with external radiotherapy 46 Gy in 23 fractions with weekly cisplatin and MRI-guided BT 7 Gy × 4 fractions with a minimum dose of 85.7 Gy (EQD2) to the high-risk clinical target volume (HRCTV). The BT dose was initially prescribed to point A and plans were optimized to ensure coverage of both point A and HRCTV while maintaining doses to the organs at risk within the recommended constraints...
November 1, 2017: Brachytherapy
https://www.readbyqxmd.com/read/29102739/the-role-of-125-i-interstitial-brachytherapy-for-inoperable-parotid-gland-carcinoma
#8
Ming-Wei Huang, Wen-Jie Wu, Xiao-Ming Lv, Guang-Yan Yu, Jian-Guo Zhang
PURPOSE: The treatment of inoperable parotid gland carcinoma is challenging and controversial. The purpose of this paper was to present our experience in treating this malignancy using (125)I interstitial brachytherapy. METHODS AND MATERIALS: Thirteen patients with advanced carcinomas of the parotid gland were included and treated with (125)I interstitial brachytherapy in Peking University School and Hospital of Stomatology from January 2003 to December 2015. All patients were treated with (125)I interstitial brachytherapy as a sole modality for the primary tumor...
November 1, 2017: Brachytherapy
https://www.readbyqxmd.com/read/29102738/manual-vs-automated-implantation-of-seeds-in-prostate-brachytherapy-oncologic-results-from-a-single-center-study
#9
Laurence Thomas, Antony Chemin, Nicolas Leduc, Sarah Belhomme, Emilie Rich, Olivier Lasbareilles, Antoine Giraud, Edouard Descat, Guilhem Roubaud, Paul Sargos
PURPOSE: The objective of this study was to study survival and tolerance of prostate cancer patients treated with (125)I permanent interstitial brachytherapy by automated vs. manual implantation of seeds. METHODS AND MATERIALS: Between 2002 and 2010, 349 selected patients were treated with (125)I brachytherapy by the same team: from 2002 to April 2005, 65 patients with linked seeds and then 284 patients treated using Nucletron First System automated implantation...
November 1, 2017: Brachytherapy
https://www.readbyqxmd.com/read/29097137/3t-multiparametric-mri-guided-high-dose-rate-combined-intracavitary-and-interstitial-adaptive-brachytherapy-for-the-treatment-of-cervical-cancer-with-a-novel-split-ring-applicator
#10
Elisha Fredman, Bryan Traughber, Tarun Podder, Valdir Colussi, Yiran Zheng, Suzanne Russo, Karin Herrmann, Raj Paspulati, Steven Waggoner, Kristin Zanotti, Christa Nagel, John Nakayama, Mitchell Machtay, Rodney Ellis
PURPOSE: To evaluate the role of 3T-MRI-guided adaptive high-dose-rate (HDR) combined intracavitary and interstitial brachytherapy for cervical cancer using a novel intracavitary split-ring (ICSR) applicator adapter. METHODS AND MATERIALS: We retrospectively reviewed all HDR brachytherapy cases from 2013 to 2015 using an ICSR applicator. Initial optimization was performed using 3T multiparametric MRI (mpMRI) series with an applicator in place. The mpMRI series were discretionarily acquired before subsequent fractions for possible target adaptation...
October 30, 2017: Brachytherapy
https://www.readbyqxmd.com/read/29097136/impact-of-radiotherapy-modalities-on-outcomes-in-the-adjuvant-management-of-uterine-carcinosarcoma-a-national-cancer-database-analysis
#11
William A Stokes, Bernard L Jones, Tracey E Schefter, Christine M Fisher
PURPOSE: In the postoperative management of uterine carcinosarcoma (UCS), the roles of individual radiotherapy (RT) modalities, chiefly external-beam radiotherapy (EBRT) and brachytherapy (BT), remain undefined. We analyzed the survival impact of EBRT and BT using the National Cancer Database. METHODS AND MATERIALS: We abstracted women diagnosed with UCS from 2004 to 2012 who received hysterectomy and had complete RT information. Cox multivariate analysis and propensity-score matched analyses were used to compare survival among radiotherapeutic approaches...
October 30, 2017: Brachytherapy
https://www.readbyqxmd.com/read/29089277/early-outcomes-and-impact-of-a-hybrid-ic-is-applicator-for-a-new-mri-based-cervical-brachytherapy-program
#12
Matthew M Harkenrider, Murat Surucu, Grant Harmon, Michael L Mysz, Steven M Shea, Joseph Yacoub, Ari Goldberg, Margaret Liotta, Abigail Winder, Ronald Potkul, John C Roeske, William Small
PURPOSE: The purpose of this study was to report early outcomes and assess the learning curve in a new MRI-based cervical brachytherapy program. METHODS: We accrued 33 patients prospectively, and only patients with ≥3 months' followup (n = 27) were assessed for disease control and toxicity. Eras were defined as first half and second half for the intracavitary (IC)-only era (n = 13 each), and the intracavitary/interstitial (IC/IS) era was separated by difference in applicator availability (n = 7)...
October 28, 2017: Brachytherapy
https://www.readbyqxmd.com/read/29089276/long-term-evaluation-of-urinary-sexual-and-quality-of-life-outcomes-after-brachytherapy-for-penile-carcinoma
#13
Dimitri Gambachidze, Cédric Lebacle, Pierre Maroun, Alexandre Escande, Alberto Bossi, Pierre Blanchard, Eric Deutsch, Christine Haie-Meder, Cyrus Chargari
PURPOSE: Brachytherapy (BT) is an effective organ-preserving treatment for selected localized penile carcinoma, providing high local control rates. Long-term functional results however, are still insufficiently evaluated. METHODS AND MATERIALS: All consecutive patients treated with low-dose-rate or pulse-dose-rate BT in our institute for a localized penile cancer and who were in first complete remission and followed for at least 3 years were included. A self-reporting questionnaire was sent, to assess: 1/urinary function, 2/sexual function, 3/cosmetic aspect of the penis, and 4/quality of life...
October 28, 2017: Brachytherapy
https://www.readbyqxmd.com/read/29089275/long-term-outcomes-of-apbi-via-multicatheter-interstitial-hdr-brachytherapy-results-of-a-prospective-single-institutional-registry
#14
Prashant Gabani, Amy E Cyr, Jacqueline E Zoberi, Laura L Ochoa, Melissa A Matesa, Maria A Thomas, Jose Garcia, Julie A Margenthaler, Michael J Naughton, Cynthia Ma, Souzan Sanati, Imran Zoberi
PURPOSE: Long-term outcome reports of accelerated partial-breast irradiation (APBI) are limited. Here, we report the 10-year outcomes of APBI delivered using multicatheter interstitial implant (ISI) brachytherapy. METHODS AND MATERIALS: Patients with early-stage breast cancer treated with APBI via ISI brachytherapy were enrolled in a prospective registry. Selection criteria included age ≥40 years, ductal carcinoma in situ or invasive tumor ≤3 cm, negative margins (≥2 mm), and negative axillary nodes...
October 28, 2017: Brachytherapy
https://www.readbyqxmd.com/read/29110967/experience-of-using-mosfet-detectors-for-dose-verification-measurements-in-an-end-to-end-192-ir-brachytherapy-quality-assurance-system
#15
Maria Persson, Josef Nilsson, Åsa Carlsson Tedgren
PURPOSE: Establishment of an end-to-end system for the brachytherapy (BT) dosimetric chain could be valuable in clinical quality assurance. Here, the development of such a system using MOSFET (metal oxide semiconductor field effect transistor) detectors and experience gained during 2 years of use are reported with focus on the performance of the MOSFET detectors. METHODS AND MATERIALS: A bolus phantom was constructed with two implants, mimicking prostate and head & neck treatments, using steel needles and plastic catheters to guide the (192)Ir source and house the MOSFET detectors...
October 27, 2017: Brachytherapy
https://www.readbyqxmd.com/read/29074088/the-american-brachytherapy-society-consensus-statement-for-accelerated-partial-breast-irradiation
#16
Chirag Shah, Frank Vicini, Simona F Shaitelman, Jaroslaw Hepel, Martin Keisch, Douglas Arthur, Atif J Khan, Robert Kuske, Rakesh Patel, David E Wazer
PURPOSE: Adjuvant radiation after breast-conserving surgery remains the standard-of-care treatment for patients with ductal carcinoma in situ and early-stage invasive breast cancer. Multiple alternatives to standard whole-breast irradiation exist including accelerated partial-breast irradiation (APBI). Therefore, the purpose of this APBI guideline is to provide updated data for clinicians as well as recommendations regarding appropriate patient selection and techniques to deliver APBI...
October 23, 2017: Brachytherapy
https://www.readbyqxmd.com/read/29066085/delineating-the-relationship-between-point-a-prescription-dose-and-pelvic-lymph-node-doses-in-intracavitary-high-dose-rate-brachytherapy-treatment-of-cervical-cancer-for-use-in-low-and-middle-income-countries
#17
John Weaver, Grant Harmon, Matthew M Harkenrider, Murat Surucu, Abbie Wood, Fiori Alite, William Small
PURPOSE: To define the relationship between the Point A prescription dose and the dose delivered to various pelvic lymph node groups during high-dose-rate (HDR) brachytherapy treatment of cervical cancer. In less developed countries, brachytherapy is often done without three-dimensional image guidance, instead relying on plain radiography and prescription to Point A. A defined relationship between Point A dose and lymph node doses would help physicians in these health care settings to more accurately estimate nodal doses...
October 21, 2017: Brachytherapy
https://www.readbyqxmd.com/read/29032014/high-intermediate-prostate-cancer-treated-with-low-dose-rate-brachytherapy-with-or-without-androgen-deprivation-therapy
#18
Tom Pickles, W James Morris, Mira Keyes
PURPOSE: To describe outcomes of men with unfavorable (high-tier) intermediate risk prostate cancer (H-IR) treated with low-dose-rate (LDR) brachytherapy, with or without 6 months of androgen deprivation therapy (ADT). METHODS AND MATERIALS: Patients with H-IR prostate cancer, treated before 2012 with LDR brachytherapy without external radiation are included. Baseline tumor characteristics are described. Outcomes between groups receiving ADT are measured by Phoenix (nadir +2 ng/mL), and threshold 0...
October 11, 2017: Brachytherapy
https://www.readbyqxmd.com/read/29032999/a-prospective-phase-i-comparison-of-toxicity-and-cosmesis-outcomes-of-single-fraction-iort-and-hypofractionated-radiotherapy-with-iort-boost-in-early-stage-breast-cancer
#19
Tanuja Bhandari, Wesley Babaran, Afshin Forouzannia, Venita Williams, Jay Harness, Michele Carpenter, Maher Gobran, Rajesh Khanijou, Brittany Wagman, Robert Ash, Lawrence D Wagman
PURPOSE: Radiation therapy is proven to reduce local recurrence in patients with early-stage breast cancer. To reduce toxicity, treatment time, and improve accuracy, intraoperative radiation therapy was used as definitive treatment or as a boost. The study's objective was to compare the short-term toxicity and cosmesis of single-fraction (SF) IORT and hypofractionated radiotherapy with IORT boost (HfB) given as definitive treatment. METHODS AND MATERIALS: Between March 2011 and December 2013, 57 patients aged 45-91 years and 24 patients aged 43-83 years (total n = 81) with Stage 0-II were treated with SF or HfB (Mobetron, IntraOp Medical, Sunnyvale, CA)...
October 9, 2017: Brachytherapy
https://www.readbyqxmd.com/read/28993108/evaluation-of-interfractional-variation-of-organs-and-displacement-of-catheters-during-high-dose-rate-interstitial-brachytherapy-for-gynecologic-malignancies
#20
Soyoung Lee, Ellis Rodney, Bryan Traughber, Tithi Biswas, Valdir Colussi, Tarun Podder
PURPOSE: To investigate the dosimetric effects due to interfractional changes in catheter position and variation in patient's anatomy during the course of interstitial high-dose-rate (HDR) brachytherapy. METHODS AND MATERIALS: A total of 15 patients with either cervical or vaginal cancer underwent interstitial HDR brachytherapy. Interstitial catheters and fiducials were placed under fluoroscopy and intraoperative 3T MRI to confirm the desired catheter placement for adequate target volume coverage...
October 6, 2017: Brachytherapy
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