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Brachytherapy

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https://www.readbyqxmd.com/read/28522118/a-national-survey-of-hdr-source-knowledge-among-practicing-radiation-oncologists-and-residents-establishing-a-willingness-to-pay-threshold-for-cobalt-60-usage
#1
Raymond Mailhot Vega, Wesley Talcott, Omar Ishaq, Patrice Cohen, Christina J Small, Tamara Duckworth, Gustavo Sarria Bardales, Carmen A Perez, Peter B Schiff, William Small, Matthew M Harkenrider
PURPOSE: Ir-192 is the predominant source for high-dose-rate (HDR) brachytherapy in United States markets. Co-60, with longer half-life and fewer source exchanges, has piloted abroad with comparable clinical dosimetry but increased shielding requirements. We sought to identify practitioner knowledge of Co-60 and establish acceptable willingness-to-pay (WTP) thresholds for additional shielding requirements for use in future cost-benefit analysis. METHODS AND MATERIALS: A nationwide survey of U...
May 15, 2017: Brachytherapy
https://www.readbyqxmd.com/read/28511891/external-pelvic-and-vaginal-irradiation-vs-vaginal-irradiation-alone-as-postoperative-therapy-in-women-with-early-stage-uterine-serous-carcinoma-results-of-a-national-cancer-database-analysis
#2
Ankit Modh, Charlotte Burmeister, Adnan R Munkarah, Mohamed A Elshaikh
PURPOSE: Adjuvant treatment in early stage uterine serous carcinoma (USC) usually consists of chemotherapy with vaginal brachytherapy (VB), pelvic external beam radiation therapy (EBRT), or combination. We compared survival outcomes across these various radiation treatment modalities using the National Cancer Database. METHODS AND MATERIALS: The National Cancer Database was queried for adult females with histologically confirmed International Federation of Gynecology and Obstetrics 1988 Stage I-II USC diagnosed from 2003 to 2013 treated definitively with hysterectomy, adjuvant chemotherapy, and radiation therapy...
May 13, 2017: Brachytherapy
https://www.readbyqxmd.com/read/28501429/permanent-prostate-brachytherapy-postimplant-mri-dosimetry-using-positive-contrast-mri-markers
#3
Geoffrey V Martin, Thomas J Pugh, Usama Mahmood, Rajat J Kudchadker, Jihong Wang, Teresa L Bruno, Tharakeswara Bathala, Pierre Blanchard, Steven J Frank
PURPOSE: Permanent prostate brachytherapy dosimetry using computed tomography-magnetic resonance imaging (CT-MRI) fusion combines the anatomic detail of MRI with seed localization on CT but requires multimodality imaging acquisition and fusion. The purpose of this study was to compare the utility of MRI only postimplant dosimetry to standard CT-MRI fusion-based dosimetry. METHODS AND MATERIALS: Twenty-three patients undergoing permanent prostate brachytherapy with use of positive contrast MRI markers were included in this study...
May 10, 2017: Brachytherapy
https://www.readbyqxmd.com/read/28499488/in%C3%A2-vivo-dosimetry-with-alanine-electron-spin-resonance-dosimetry-to-evaluate-the-urethra-dose-during-high-dose-rate-brachytherapy
#4
Daniela Wagner, Markus Hermann, Andrea Hille
PURPOSE: To determine the dose of the urethra during Ir-192 high-dose-rate brachytherapy in 15 patients, a new detector form developed for in vivo measurements was used as described by Anton et al. 2009. METHODS AND MATERIALS: The detector consists of alanine powder with paraffin as binder which was filled in a shrinkable tube for measurements. The alanine strand so produced was inserted in the foley catheter during high-dose-rate brachytherapy of the prostate...
May 9, 2017: Brachytherapy
https://www.readbyqxmd.com/read/28499487/external-beam-radiation-therapy-with-or-without-low-dose-rate-brachytherapy-analysis-of-favorable-and-unfavorable-intermediate-risk-prostate-cancer-patients
#5
Ahmed E Abugharib, Robert T Dess, Payal D Soni, Vrinda Narayana, Cheryl Evans, Mohamed S Gaber, Felix Y Feng, Patrick W McLaughlin, Daniel E Spratt
PURPOSE: To compare the tumor control and toxicity in men with intermediate-risk prostate cancer treated with either external beam radiation therapy (EBRT) or EBRT plus low-dose-rate brachytherapy (combo-RT). METHODS AND MATERIALS: Between 1995 and 2012, 579 men with intermediate-risk prostate cancer were treated with either EBRT (n = 388) or combo-RT (n = 191). Outcomes assessed included biochemical recurrence-free survival (bRFS), distant metastasis-free survival (DMFS), and cumulative incidence of genitourinary (GU) and gastrointestinal toxicity...
May 9, 2017: Brachytherapy
https://www.readbyqxmd.com/read/28495444/comparing-the-rtog-eortc-and-lent-soma-scoring-systems-for-the-evaluation-of-late-skin-toxicity-after-125-i-seed-brachytherapy-for-parotid-gland-cancer
#6
Ming-Hui Mao, Zhien Feng, Hua Li, Li-Zheng Qin, Jian-Hua Li, Xin Huang, Ru-Dong Xing, Jie Zhang, Jian-Guo Zhang, Zheng-Xue Han
PURPOSE: The Radiation Therapy Oncology Group (RTOG) and Late Effects Normal Tissue Task Force-Subjective, Objective, Management and Analytic (LENT-SOMA) scoring systems were compared for grading late skin effects after iodine-125 seed brachytherapy in parotid gland cancer patients. METHODS AND MATERIALS: A total of 109 patients diagnosed with parotid gland carcinoma were treated postoperatively with iodine-125 seed brachytherapy at a dose of 100-120 Gy. After 6-24 months of followup, telangiectasia, skin pigmentation, atrophy, fibrosis, and ulceration were scored according to both RTOG and LENT-SOMA scale criteria...
May 8, 2017: Brachytherapy
https://www.readbyqxmd.com/read/28495443/dose-volume-correlation-of-cumulative-vaginal-doses-and-late-toxicity-after-adjuvant-external-radiation-and-brachytherapy-for-cervical-cancer
#7
Roshni Singh, Supriya Chopra, Reena Engineer, Siji Paul, Sadhana Kannan, Sarthak Mohanty, Jamema Swamidas, Umesh Mahantshetty, Jaya Ghosh, Amita Maheshwari, T Surappa Shylasree, Rajendra Kerkar, Sudeep Gupta, Shyam Shrivastava
PURPOSE: To investigate dose-response relationship between vaginal doses and long-term morbidity. METHODS AND MATERIALS: Patients receiving adjuvant pelvic (chemo) radiation and brachytherapy for cervical cancer from January 2011 to December 2014 were included. Baseline vaginal length was determined clinically and from imaging at BT planning. Dose points were defined along mucosa and at 5 mm depth at 12, 3, 6, and 9 'o' clock positions at every 2 cm from apex to introitus...
May 8, 2017: Brachytherapy
https://www.readbyqxmd.com/read/28495442/validation-of-plastic-scintillation-detectors-for-applications-in-low-dose-rate-brachytherapy
#8
François Therriault-Proulx, Luc Beaulieu, Sam Beddar
PURPOSE: To develop a plastic scintillation detector (PSD) capable of accurately measuring dose around a low-dose-rate (LDR) iodine-125 ((125)I) radioactive seed as a first step toward in vivo dosimetry for prostate LDR brachytherapy. METHODS: Using a GEANT4 based Monte Carlo code, photon energy distribution at any position around a realistic (125)I source model was obtained. This energy distribution was convolved with the expected energy response from a plastic scintillator and dosimetry accuracy was evaluated...
May 8, 2017: Brachytherapy
https://www.readbyqxmd.com/read/28479189/mri-based-salvage-brachytherapy-moving-toward-a-focal-paradigm
#9
Marisa A Kollmeier, Michael Zelefsky, Sean McBride
Brachytherapy is an ideal treatment approach for radiorecurrent prostate cancer given the highly conformal treatment. Increasingly, multiparametric magnetic resonance imaging is being utilized to enhance our ability to assess intraprostatic tumor characteristics. This article aims to review the current literature on whole gland salvage brachytherapy for radiorecurrent prostate cancer as well as the methodology and progress towards a focal approach to salvage brachytherapy. Particular emphasis is placed on the potential role of multiparametric MRI in achieving optimal outcomes with focal salvage brachytherapy...
May 4, 2017: Brachytherapy
https://www.readbyqxmd.com/read/28460998/institutional-long-term-outcomes-at-the-first-canadian-center-performing-intraoperatively-planned-low-dose-rate-brachytherapy-alone-in-low-and-intermediate-risk-prostate-cancer
#10
Michael Peacock, Kevin Martell, Amandeep Taggar, Tyler Meyer, Wendy Smith, Michael Sia, Steve Angyalfi, Siraj Husain
PURPOSE: The aim of this study is to report the long-term outcomes and toxicities from a large cohort of patients with localized prostate cancer treated with low-dose-rate intraoperatively planned brachytherapy. METHODS AND MATERIALS: Prostate-specific antigen levels, urinary symptoms, and erectile function were recorded at baseline, and each followup visit was then entered into a prospective database. Urinary toxicity requiring procedural intervention was retrospectively verified using an integrated electronic medical system...
April 28, 2017: Brachytherapy
https://www.readbyqxmd.com/read/28460997/the-declining-utilization-of-brachytherapy-for-the-treatment-of-prostate-cancer-can-magnetic-resonance-imaging-reverse-the-trend
#11
REVIEW
Usama Mahmood
The utilization of brachytherapy for the treatment of prostate cancer has fluctuated over the years. Whereas initial excitement led to rapid expansion of this modality, more recent data suggest that prostate brachytherapy is in decline. This article reviews previous and current trends in the utilization of prostate brachytherapy and postulates the potential impact of the integration of magnetic resonance imaging imaging on this modality.
April 28, 2017: Brachytherapy
https://www.readbyqxmd.com/read/28457741/commissioning-of-applicator-guided-stereotactic-body-radiation-therapy-boost-with-high-dose-rate-brachytherapy-for-advanced-cervical-cancer-using-radiochromic-film-dosimetry
#12
Saad Aldelaijan, Shada Wadi-Ramahi, Ahmad Nobah, Belal Moftah, Slobodan Devic, Noha Jastaniyah
PURPOSE: To describe an EBT3 GAFCHROMIC film-based dosimetry method to be used in commissioning of a combined HDR brachytherapy (HDRB) and stereotactic body radiation therapy (SBRT) boost for treatment of advanced cervical cancer involving extensive residual disease after external beam treatment. METHODS AND MATERIALS: A cube phantom was designed to firmly fit an intrauterine tandem applicator and EBT3 radiochromic film pieces. A high-risk clinical target volume (CTVHR, Total) was contoured with an extended arm at one side...
April 27, 2017: Brachytherapy
https://www.readbyqxmd.com/read/28455092/use-of-3d-transabdominal-ultrasound-imaging-for-treatment-planning-in-cervical-cancer-brachytherapy-comparison-to-magnetic-resonance-and-computed-tomography
#13
Patricia St-Amant, William Foster, Marie-Anne Froment, Sylviane Aubin, Marie-Claude Lavallée, Luc Beaulieu
PURPOSE: To evaluate if the addition of 3D transabdominal ultrasound (3DTAUS) imaging to computed tomography (CT) can improve treatment planning in 3D adaptive brachytherapy when compared with CT-based planning alone, resulting in treatment plans closer to the ones obtained using magnetic resonance imaging (MRI)-based planning. METHODS AND MATERIALS: Five patients with cervical cancer undergoing brachytherapy underwent three imaging modalities: MRI, CT, and CT-3DTAUS...
April 25, 2017: Brachytherapy
https://www.readbyqxmd.com/read/28442277/prostate-brachytherapy-either-alone-or-in-combination-with-external-beam-radiation-is-associated-with-longer-overall-survival-in-men-with-favorable-pathologic-group-4-gleason-score-8-prostate-cancer
#14
Matthew W Jackson, Arya Amini, Bernard L Jones, Brian Kavanagh, Paul Maroni, Steven J Frank, Usama Mahmood, Rajat J Kudchadker, Thomas J Pugh
PURPOSE: Conventional prostate cancer risk stratification results in considerable heterogeneity within each prognostic group. Men with pathologic grade Group 4 (Gleason score 8) but otherwise low-risk features have been identified as a favorable subset of high-risk prostate cancer. Given recent randomized data supporting improved cancer outcome with brachytherapy in intermediate- and high-risk prostate cancer, we sought to evaluate brachytherapy utilization and overall survival (OS) for these patients...
April 23, 2017: Brachytherapy
https://www.readbyqxmd.com/read/28396178/magnetic-resonance-imaging-basics-for-the-prostate-brachytherapist
#15
REVIEW
Jihong Wang, Kari Tanderup, Adam Cunha, Antonio L Damato, Gil'ad N Cohen, Rajat J Kudchadker, Firas Mourtada
Magnetic resonance imaging (MRI) is increasingly being used in radiation therapy, and integration of MRI into brachytherapy in particular is becoming more common. We present here a systematic review of the basic physics and technical aspects of incorporating MRI into prostate brachytherapy. Terminology and MRI system components are reviewed along with typical work flows in prostate high-dose-rate and low-dose-rate brachytherapy. In general, the brachytherapy workflow consists of five key components: diagnosis, implantation, treatment planning (scan + plan), implant verification, and delivery...
April 7, 2017: Brachytherapy
https://www.readbyqxmd.com/read/28392144/iridium-knife-another-knife-in-radiation-oncology
#16
Natasa Milickovic, Nikolaos Tselis, Efstratios Karagiannis, Konstantinos Ferentinos, Nikolaos Zamboglou
PURPOSE: Intratarget dose escalation with superior conformity is a defining feature of three-dimensional (3D) iridium-192 ((192)Ir) high-dose-rate (HDR) brachytherapy (BRT). In this study, we analyzed the dosimetric characteristics of interstitial (192)Ir HDR BRT for intrathoracic and cerebral malignancies. We examined the dose gradient sharpness of HDR BRT compared with that of linear accelerator-based stereotactic radiosurgery and stereotactic body radiation therapy, usually called X-Knife, to demonstrate that it may as well be called a Knife...
April 6, 2017: Brachytherapy
https://www.readbyqxmd.com/read/28343795/use-of-mri-in-low-dose-rate-and-high-dose-rate-prostate-brachytherapy-from-diagnosis-to-treatment-assessment-defining-the-knowledge-gaps-technical-challenges-and-barriers-to-implementation
#17
S J Frank, F Mourtada, J Crook, C Ménard
MRI is rapidly evolving as an imaging tool in both low-dose-rate and high-dose-rate brachytherapy for prostate cancer. The ability of MRI to identify intraprostatic tumors and reduce uncertainties in the workflow process should enable a more accurate and precise radiation delivery approach while simultaneously improving the quality assurance process. The ability to identify functional anatomic structures adjacent to the prostate cancer could reduce or eliminate some of the more common side effects of the treatment...
March 23, 2017: Brachytherapy
https://www.readbyqxmd.com/read/28284511/permanent-prostate-brachytherapy-pubic-arch-evaluation-with-diagnostic-mri
#18
Geoffrey V Martin, Thomas J Pugh, Usama Mahmood, Rajat J Kudchadker, Jihong Wang, Teresa L Bruno, Tharakeswara Bathala, Steven J Frank
PURPOSE: Pubic arch interference (PAI), when it occurs, is often a limiting factor for patients pursuing brachytherapy treatment of prostate cancer. Pre-brachytherapy pubic arch evaluation is often performed by CT or transrectal ultrasound (TRUS), but MRI has increasingly replaced these modalities for prostate cancer evaluation. The purpose of this study was to determine if staging MRI could be used to evaluate PAI and compare it with these other imaging methods. METHODS AND MATERIALS: Forty-one consecutive patients undergoing brachytherapy evaluation had pelvic MRI-, CT-, and TRUS-based brachytherapy simulation...
March 8, 2017: Brachytherapy
https://www.readbyqxmd.com/read/28274757/an-evaluation-of-our-experience-in-position-verification-of-catheters-used-for-interstitial-high-dose-rate-brachytherapy-of-solitary-bladder-tumors
#19
S J E A Bus, N G Leus, B J Oosterveld, M P R Van Gellekom, G J M van de Loop, E M van der Steen-Banasik
PURPOSE: The goal of this study was to verify the position of catheters used over 4 days for brachytherapy of solitary bladder tumors. METHODS AND MATERIALS: The study covered three phases. Shifting of catheters was studied using daily position verification CT scans of 20 patients. The possibility to omit the CT scan on Day 2 by adding a loading margin of 4 mm on each side was studied using data of 5 patients. Whether the Day 4 verification CT scan could be omitted if this margin was used, was studied for another group of 10 patients, comparing the Day 3 treatment plan to the Day 4 CT scan...
March 5, 2017: Brachytherapy
https://www.readbyqxmd.com/read/28237429/prostate-mri-for-brachytherapists-anatomy-and-technique
#20
A M Venkatesan, R J Stafford, C Duran, P D Soni, A Berlin, P W McLaughlin
PURPOSE: To present an overview of mp MRI techniques necessary for high-resolution imaging of prostate. METHODS: We summarize examples from our clinical experience and concepts from the current literature that illustrate normal prostate anatomy on multiparametric MRI (mp MRI). RESULTS: Our experience regarding optimal mp MRI image acquisition is provided, as well as a summary of prostate and periprostatic anatomy and anatomical variants that pose challenges for BT...
February 23, 2017: Brachytherapy
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