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Brachytherapy

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https://www.readbyqxmd.com/read/28396178/magnetic-resonance-imaging-basics-for-the-prostate-brachytherapist
#1
REVIEW
Jihong Wang, Kari Tanderup, Adam Cunha, Antonio L Damato, Gil'ad N Cohen, Rajat J Kudchadker, Firas Mourtada
Magnetic resonance imaging (MRI) is increasingly being used in radiation therapy, and integration of MRI into brachytherapy in particular is becoming more common. We present here a systematic review of the basic physics and technical aspects of incorporating MRI into prostate brachytherapy. Terminology and MRI system components are reviewed along with typical work flows in prostate high-dose-rate and low-dose-rate brachytherapy. In general, the brachytherapy workflow consists of five key components: diagnosis, implantation, treatment planning (scan + plan), implant verification, and delivery...
April 7, 2017: Brachytherapy
https://www.readbyqxmd.com/read/28392144/iridium-knife-another-knife-in-radiation-oncology
#2
Natasa Milickovic, Nikolaos Tselis, Efstratios Karagiannis, Konstantinos Ferentinos, Nikolaos Zamboglou
PURPOSE: Intratarget dose escalation with superior conformity is a defining feature of three-dimensional (3D) iridium-192 ((192)Ir) high-dose-rate (HDR) brachytherapy (BRT). In this study, we analyzed the dosimetric characteristics of interstitial (192)Ir HDR BRT for intrathoracic and cerebral malignancies. We examined the dose gradient sharpness of HDR BRT compared with that of linear accelerator-based stereotactic radiosurgery and stereotactic body radiation therapy, usually called X-Knife, to demonstrate that it may as well be called a Knife...
April 6, 2017: Brachytherapy
https://www.readbyqxmd.com/read/28391989/towards-clinical-application-of-raystretch-for-heterogeneity-corrections-in-ldr-permanent-125-i-prostate-brachytherapy
#3
Fernando Hueso-González, Facundo Ballester, Jose Perez-Calatayud, Frank-André Siebert, Javier Vijande
PURPOSE: RayStretch is a simple algorithm proposed for heterogeneity corrections in low-dose-rate brachytherapy. It is built on top of TG-43 consensus data, and it has been validated with Monte Carlo (MC) simulations. In this study, we take a real clinical prostate implant with 71 (125)I seeds as reference and we apply RayStretch to analyze its performance in worst-case scenarios. METHODS AND MATERIALS: To do so, we design two cases where large calcifications are located in the prostate lobules...
April 5, 2017: Brachytherapy
https://www.readbyqxmd.com/read/28377213/risk-factors-and-state-of-the-art-indications-for-boost-irradiation-in-invasive-breast-carcinoma
#4
REVIEW
Alfredo Polo, Csaba Polgár, Jean-Michel Hannoun-Levi, Jose-Luis Guinot, Cristina Gutierrez, Razvan Galalae, Erik van Limbergen, Vratislav Strnad
PURPOSE: The aim of the study was to give recommendations on patient selection criteria for the administration of boost doses after whole-breast irradiation (WBI) in invasive breast cancer based on available clinical evidence complemented by expert opinion. METHODS AND MATERIALS: A systematic search of the PubMed database was conducted to identify factors associated with increased risk for local failure that can define risk groups, and to provide evidence for an adequate guidance to the use of the boost as a function of the risk of local recurrence in breast-conserving therapy...
April 1, 2017: Brachytherapy
https://www.readbyqxmd.com/read/28366277/letter-to-the-editor-on-prostate-specific-antigen-density-is-predictive-of-outcome-in-suboptimal-prostate-seed-brachytherapy
#5
LETTER
Reza Pakzad, Saeid Safiri
No abstract text is available yet for this article.
March 30, 2017: Brachytherapy
https://www.readbyqxmd.com/read/28366276/high-dose-rate-brachytherapy-boost-for-prostate-cancer-analysis-of-dose-volume-histogram-parameters-for-predicting-late-rectal-toxicity
#6
Rodolfo Chicas-Sett, Dolores Farga, Maria J Perez-Calatayud, Francisco Celada, Susana Roldan, Victoria Fornes-Ferrer, Blanca Ibanez-Rosello, Alejandro Tormo, Jose M Benlloch, Jose Perez-Calatayud
PURPOSE: To determine the significance of dose-volume histogram parameters for predicting late rectal toxicity (LRT) after single-fraction high-dose-rate brachytherapy (HDRBT) boost and external beam radiotherapy (EBRT) in prostate cancer. MATERIALS AND METHODS: Three hundred patients with intermediate- or high-risk prostate cancer were included between August 2010 and March 2015. Treatment comprised a single-fraction HDRBT boost of 15.0 Gy plus EBRT (46.0 Gy delivered in 23 fractions) or an HDRBT boost of 9...
March 30, 2017: Brachytherapy
https://www.readbyqxmd.com/read/28365085/authors-response
#7
LETTER
Daniel Taussky
No abstract text is available yet for this article.
March 29, 2017: Brachytherapy
https://www.readbyqxmd.com/read/28365084/perianal-synovial-sarcoma-treated-postoperatively-with-iodine-125-brachytherapy-technical-details
#8
Susan Tovey, Clare Stannard, Gerrie Maree, Robin Hiscock, Charlie Thomson, Eugenio Panieri, Paul Goldberg
PURPOSE: A 23-year-old lady had an incompletely excised perianal sarcoma. Brachytherapy as the sole treatment, rather than further surgery or external beam radiotherapy, was considered to be the best option with the least morbidity. METHODS AND MATERIALS: Although brachytherapy techniques with iridium-192 for anal and rectal carcinoma are well described using a perianal template, the size of the template was not suitable for a two-plane implant that needed to be in situ for about 4 days...
March 29, 2017: Brachytherapy
https://www.readbyqxmd.com/read/28365083/clinical-transition-to-model-based-dose-calculation-algorithm-a-retrospective-analysis-of-high-dose-rate-tandem-and-ring-brachytherapy-of-the-cervix
#9
Dayee Jacob, Melissa Lamberto, Lana DeSouza Lawrence, Firas Mourtada
PURPOSE: To retrospectively compare clinical dosimetry of CT-based tandem-ring treatment plans using a model-based dose calculation algorithm (MBDCA) with the standard TG-43-based dose formalism. METHODS AND MATERIALS: A cohort of 10 cervical cancer cohorts treated using the tandem and ring high-dose-rate applicators were evaluated. The original treatment plans were created using the department CT-based volume optimization clinical standards. All plans originally calculated with TG-43 dose calculation formalism were recalculated using the MBDCA algorithm...
March 29, 2017: Brachytherapy
https://www.readbyqxmd.com/read/28343795/use-of-mri-in-low-dose-rate-and-high-dose-rate-prostate-brachytherapy-from-diagnosis-to-treatment-assessment-defining-the-knowledge-gaps-technical-challenges-and-barriers-to-implementation
#10
S J Frank, F Mourtada, J Crook, C Ménard
MRI is rapidly evolving as an imaging tool in both low-dose-rate and high-dose-rate brachytherapy for prostate cancer. The ability of MRI to identify intraprostatic tumors and reduce uncertainties in the workflow process should enable a more accurate and precise radiation delivery approach while simultaneously improving the quality assurance process. The ability to identify functional anatomic structures adjacent to the prostate cancer could reduce or eliminate some of the more common side effects of the treatment...
March 23, 2017: Brachytherapy
https://www.readbyqxmd.com/read/28342738/american-brachytherapy-society-consensus-statement-for-soft-tissue-sarcoma-brachytherapy
#11
A O Naghavi, D C Fernandez, N Mesko, A Juloori, A Martinez, J G Scott, C Shah, L B Harrison
PURPOSE: Radiation therapy represents an essential treatment option in the management of soft tissue sarcomas (STS). Brachytherapy represents an important subset of radiation therapy techniques used for STS, with evolving indications and applications. Therefore, the purpose of this guideline was to update clinicians regarding the data surrounding brachytherapy (BT) and provide recommendations for the utilization of BT in patients with STS. METHODS AND MATERIALS: Members of the American Brachytherapy Society with expertise in STS, and STS BT in particular, created an updated guideline for the use of BT in STS based on a literature review and clinical experience...
March 22, 2017: Brachytherapy
https://www.readbyqxmd.com/read/28336252/trends-in-cervical-cancer-brachytherapy-volume-suggest-case-volume-is-not-the-primary-driver-of-poor-compliance-rates-with-brachytherapy-delivery-for-locally-advanced-cervical-cancer
#12
Daniel M Trifiletti, Surbhi Grover, Bruce Libby, Timothy N Showalter
PURPOSE: The aim of this study was to evaluate temporal trends in the volume of cervical cancer brachytherapy cases available to trainees as a potential contributing factor to national trends toward decreased utilization of brachytherapy for locally advanced cervical cancer. METHODS AND MATERIALS: The National Cancer Database was queried to identify a cohort of women diagnosed with locally advanced cervical cancer during 2004-2013 who received primary radiation therapy...
March 20, 2017: Brachytherapy
https://www.readbyqxmd.com/read/28325472/dosimetric-comparison-between-treatment-plans-of-patients-treated-with-low-dose-rate-vs-high-dose-rate-interstitial-prostate-brachytherapy-as-monotherapy-initial-findings-of-a-randomized-clinical-trial
#13
T Major, C Polgár, K Jorgo, G Stelczer, P Ágoston
PURPOSE: The aim of this study was to compare the dosimetry of intraoperative dose plans of prostate cancer patients treated with low-dose-rate (LDR) and high-dose-rate (HDR) interstitial brachytherapy (BT). METHODS AND MATERIALS: A randomized clinical trial was initiated at our institution to compare the results and side effects of LDR and HDR BT as monotherapy in the treatment of early, organ-confined prostate cancer patients. Eighty-seven patients were randomly assigned to receive HDR afterloading BT with one fraction of 19 Gy or permanent LDR (125)I seed BT with 145 Gy...
March 15, 2017: Brachytherapy
https://www.readbyqxmd.com/read/28284511/permanent-prostate-brachytherapy-pubic-arch-evaluation-with-diagnostic-mri
#14
Geoffrey V Martin, Thomas J Pugh, Usama Mahmood, Rajat J Kudchadker, Jihong Wang, Teresa L Bruno, Tharakeswara Bathala, Steven J Frank
PURPOSE: Pubic arch interference (PAI), when it occurs, is often a limiting factor for patients pursuing brachytherapy treatment of prostate cancer. Pre-brachytherapy pubic arch evaluation is often performed by CT or transrectal ultrasound (TRUS), but MRI has increasingly replaced these modalities for prostate cancer evaluation. The purpose of this study was to determine if staging MRI could be used to evaluate PAI and compare it with these other imaging methods. METHODS AND MATERIALS: Forty-one consecutive patients undergoing brachytherapy evaluation had pelvic MRI-, CT-, and TRUS-based brachytherapy simulation...
March 8, 2017: Brachytherapy
https://www.readbyqxmd.com/read/28274757/an-evaluation-of-our-experience-in-position-verification-of-catheters-used-for-interstitial-high-dose-rate-brachytherapy-of-solitary-bladder-tumors
#15
S J E A Bus, N G Leus, B J Oosterveld, M P R Van Gellekom, G J M van de Loop, E M van der Steen-Banasik
PURPOSE: The goal of this study was to verify the position of catheters used over 4 days for brachytherapy of solitary bladder tumors. METHODS AND MATERIALS: The study covered three phases. Shifting of catheters was studied using daily position verification CT scans of 20 patients. The possibility to omit the CT scan on Day 2 by adding a loading margin of 4 mm on each side was studied using data of 5 patients. Whether the Day 4 verification CT scan could be omitted if this margin was used, was studied for another group of 10 patients, comparing the Day 3 treatment plan to the Day 4 CT scan...
March 5, 2017: Brachytherapy
https://www.readbyqxmd.com/read/28262518/management-of-elderly-patients-with-early-stage-medically-inoperable-endometrial-cancer-systematic-review-and-national-cancer-database-analysis
#16
Sunil W Dutta, Daniel M Trifiletti, Surbhi Grover, Pamela Boimel, Timothy N Showalter
PURPOSE: To evaluate the effectiveness of radiation therapy among elderly patients who are deemed medically inoperable. METHODS AND MATERIALS: We searched PubMed to identify studies from the past 25 years that reported outcomes of medically inoperable endometrial cancer patients treated with radiation alone. The National Cancer Database (NCDB) was queried to identify patients 65 years and older with Stage I-II medically inoperable endometrial cancer. Univariable and multivariable models were performed to investigate the impact of prognostic factors on overall survival...
March 2, 2017: Brachytherapy
https://www.readbyqxmd.com/read/28262517/visual-acuity-oncologic-and-toxicity-outcomes-with-103-pd-vs-125-i-plaque-treatment-for-choroidal-melanoma
#17
Kirtesh R Patel, Roshan S Prabhu, Jeffrey M Switchenko, Mudit Chowdhary, Caroline Craven, Pia Mendoza, Hasan Danish, Hans E Grossniklaus, Thomas M Aaberg, Thomas Aaberg, Sahitya Reddy, Elizabeth Butker, Chris Bergstrom, Ian R Crocker
PURPOSE: To evaluate outcomes of choroidal melanoma patients treated with (125)I or (103)Pd plaque brachytherapy. METHODS AND MATERIALS: From 1993 to 2012, our institution treated 160 patients with (103)Pd (56.1%) and 125 patients with (125)I (43.9%) plaque brachytherapy. Tumor outcomes, visual acuity (VA), and toxicity were compared. Multivariate analyses (MVAs) and propensity score analysis were used to help address differences in baseline characteristics. RESULTS: Median followup was longer for (125)I patients, 52...
March 2, 2017: Brachytherapy
https://www.readbyqxmd.com/read/28262516/brachytherapy-as-part-of-the-conservative-treatment-for-primary-and-recurrent-vulvar-carcinoma
#18
P Castelnau-Marchand, A Escande, R Mazeron, E Bentivegna, A Cavalcanti, S Gouy, C Baratiny, P Maroun, P Morice, C Haie-Meder, C Chargari
PURPOSE: There are only scarce data on the place of brachytherapy (BT) for treatment of vulvar carcinoma. Our institutional experience of interstitial BT for vulvar carcinoma patients is reported. METHODS AND MATERIALS: Clinical records of patients receiving low-dose-rate or pulsed-dose-rate BT as part of the primary treatment for primary/recurrent vulvar squamous cell carcinoma or as part of postoperative treatment between 2000 and 2015 were included. Patients, tumors, and treatment characteristics as well as clinical outcome were examined...
March 2, 2017: Brachytherapy
https://www.readbyqxmd.com/read/28256433/the-value-of-systematic-contouring-of-the-bowel-for-treatment-plan-optimization-in-image-guided-cervical-cancer-high-dose-rate-brachytherapy
#19
Antonio L Damato, Ivan Buzurovic, Mandar S Bhagwat, Robert A Cormack, Phillip M Devlin, Scott Friesen, Jorgen Hansen, Larissa J Lee, Matthias M Manuel, Linda P Cho, Desmond O'Farrell, Akila N Viswanathan
PURPOSE: To investigate the dose-volume histogram metrics and optimization results of the contoured bowel in cervical cancer brachytherapy. METHODS AND MATERIALS: Treatment plans of cervical cancer patients treated with image-guided high dose rate were retrospectively analyzed with institutional review board approval. In addition to the clinical target volume, rectum, bladder, and sigmoid, the bowel was contoured at the time of planning (Group 1) or at the time of this analysis (Group 2)...
February 27, 2017: Brachytherapy
https://www.readbyqxmd.com/read/28242194/dosimetric-impact-of-contouring-and-image-registration-variability-on-dynamic-125-i-prostate-brachytherapy
#20
Hendrik Westendorp, Kathrin Surmann, Sandrine M G van de Pol, Carel J Hoekstra, Robert A J Kattevilder, Tonnis T Nuver, Marinus A Moerland, Cornelis H Slump, André W Minken
PURPOSE: The quality of permanent prostate brachytherapy can be increased by addition of imaging modalities in the intraoperative procedure. This addition involves image registration, which inherently has inter- and intraobserver variabilities. We sought to quantify the inter- and intraobserver variabilities in geometry and dosimetry for contouring and image registration and analyze the results for our dynamic (125)I brachytherapy procedure. METHODS AND MATERIALS: Five observers contoured 11 transrectal ultrasound (TRUS) data sets three times and 11 CT data sets one time...
February 24, 2017: Brachytherapy
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