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Brachytherapy

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https://www.readbyqxmd.com/read/29779953/a-quality-assurance-device-for-measuring-afterloader-performance-and-transit-dose-for-nasobiliary-high-dose-rate-brachytherapy
#1
Christopher L Deufel, John P Mullins, Mark J Zakhary
PURPOSE: Nasobiliary high-dose-rate (HDR) brachytherapy has emerged as an effective tool to boost the radiation dose for patients with unresectable perihilar cholangiocarcinoma. This work describes a quality assurance (QA) tool for measuring the HDR afterloader's performance, including the transit dose, when the source wire travels through a tortuous nasobiliary catheter path. METHODS AND MATERIALS: The nasobiliary QA device was designed to mimic the anatomical path of a nasobiliary catheter, including the nasal, stomach, duodenum, and bile duct loops...
May 17, 2018: Brachytherapy
https://www.readbyqxmd.com/read/29776892/technique-for-the-administration-of-high-dose-rate-brachytherapy-to-the-bile-duct-using-a-nasobiliary-catheter
#2
Christopher L Deufel, Keith M Furutani, Robert A Dahl, Michael P Grams, Luke B McLemore, Christopher L Hallemeier, Michelle Neben-Wittich, James A Martenson, Michael G Haddock
PURPOSE: Cholangiocarcinoma patients who are potential candidates for liver transplantation may be treated with high-dose-rate (HDR) brachytherapy using a minimally invasive nasobiliary catheter in an effort to escalate the radiotherapy dose to the tumor and maximize local control rates. This work describes the equipment, procedures, and quality assurance (QA) that enables successful administration. METHODS AND MATERIALS: This work describes the nasobiliary catheter placement, simulation, treatment planning, treatment delivery, and QA...
May 16, 2018: Brachytherapy
https://www.readbyqxmd.com/read/29773331/novel-use-of-viewray-mri-guidance-for-high-dose-rate-brachytherapy-in-the-treatment-of-cervical-cancer
#3
Huaising C Ko, Jessie Y Huang, Jessica R Miller, Rupak K Das, Charles R Wallace, Anna-Maria A De Costa, David M Francis, Margaret R Straub, Bethany M Anderson, Kristin A Bradley
PURPOSE: To characterize image quality and feasibility of using ViewRay MRI (VR)-guided brachytherapy planning for cervical cancer. METHODS AND MATERIALS: Cervical cancer patients receiving intracavitary brachytherapy with tandem and ovoids, planned using 0.35T VR MRI at our institution, were included in this series. The high-risk clinical target volume (HR-CTV), visible gross tumor volume, bladder, sigmoid, bowel, and rectum contours for each fraction of brachytherapy were evaluated for dosimetric parameters...
May 14, 2018: Brachytherapy
https://www.readbyqxmd.com/read/29773330/improving-the-treatment-planning-and-delivery-process-of-xoft-electronic-skin-brachytherapy
#4
Ryan Manger, Douglas Rahn, Jeremy Hoisak, Irena Dragojević
PURPOSE: To develop an improved Xoft electronic skin brachytherapy process and identify areas of further improvement. METHODS AND MATERIALS: A multidisciplinary team conducted a failure modes and effects analysis (FMEA) by developing a process map and a corresponding list of failure modes. The failure modes were scored for their occurrence, severity, and detectability, and a risk priority number (RPN) was calculated for each failure mode as the product of occurrence, severity, and detectability...
May 14, 2018: Brachytherapy
https://www.readbyqxmd.com/read/29764769/comparison-of-computed-tomography-with-magnetic-resonance-imaging-for-imaging-based-clinical-target-volume-contours-in-cervical-cancer-brachytherapy
#5
Agnieszka Zolciak-Siwinska, Adam Kowalczyk, Katarzyna Sikorska, Michal Bijok, Wojciech Michalski, Ewelina Gruszczynska
PURPOSE: To compare CT- and MRI-based brachytherapy (BT) target volumes for patients with advanced cervical cancer so as to identify those who benefit most from MRI-based planning. We also studied how the natural mobility of the organ at risks (OARs) affects the given doses. METHODS AND MATERIALS: Subjects were 60 patients with International Federation of Gynecology and Obstetrics (FIGO) Stage IB-IVA cervical cancer. The CT high-risk clinical target volume (HR-CTV) was first delineated, then the MRI HR-CTV, with volume discrepancies calculated by subtraction...
May 12, 2018: Brachytherapy
https://www.readbyqxmd.com/read/29759329/comparison-of-dosimetric-and-clinical-outcomes-between-short-and-long-channel-cylinder-applicators-for-vaginal-brachytherapy-in-intermediate-and-high-risk-endometrial-cancer
#6
Michael Z Kharouta, Nghia Pham, Karina Nieto, Murat Surucu, Michael L Mysz, Kevin Albuquerque, Abigail Winder, Margaret Liotta, Ronald K Potkul, William Small, Matthew M Harkenrider
PURPOSE: Vaginal brachytherapy (VBT) using a cylinder applicator is a standard treatment of intermediate- and high-risk endometrial cancer. We conducted a retrospective study of the dosimetric and clinical outcomes at our institution with 2 single-channel applicators in patients receiving VBT. METHODS AND MATERIALS: One hundred thirty-six patients with endometrial cancer treated from 2006 to 2016 receiving VBT after definitive surgery were evaluated. Two cylinders were used with the distal dwell position 7...
May 11, 2018: Brachytherapy
https://www.readbyqxmd.com/read/29759328/a-novel-applicator-design-for-intracavitary-brachytherapy-of-the-nasopharynx-simulated-reconstruction-image-guided-adaptive-brachytherapy-planning-and-dosimetry
#7
Warren R Bacorro, Ryan Anthony F Agas, Stellar Marie R Cabrera, Maureen R Bojador, Paolo G Sogono, Michael Benedict A Mejia, Teresa T Sy Ortin
PURPOSE: In nasopharyngeal cancer, brachytherapy is given as boost in primary treatment or as salvage for recurrent or persistent disease. The Rotterdam nasopharyngeal applicator (RNA) allows for suboptimal reduction of soft palate radiation dose, based on image-guided brachytherapy plans. Building on the RNA, we propose a novel design, the Benavides nasopharyngeal applicator (BNA). METHODS AND MATERIALS: The virtual BNA was reconstructed on two cases (one T1, one T2) previously treated with intracavitary brachytherapy using the RNA...
May 11, 2018: Brachytherapy
https://www.readbyqxmd.com/read/29748084/malignant-obstructive-jaundice-treated-with-intraluminal-placement-of-iodine-125-seed-strands-and-metal-stents-an-analysis-of-long-term-outcomes-and-prognostic-features
#8
Jingqin Ma, Jianjun Luo, Junying Gu, Qingxin Liu, Lingxiao Liu, Wen Zhang, Zihan Zhang, Zhiping Yan
PURPOSE: The purpose of this study was to analyze the long-term outcomes, including safety, efficacy, and prognostic features, of intraluminal brachytherapy with Iodine-125 (125 I) seed strand and stent placement for treatment of patients with malignant obstructive jaundice (MOJ). METHODS AND MATERIALS: From January 2009 to December 2013, 107 consecutive patients with MOJ were treated with intraluminal placement of 125 I seed strands and metal stents. A retrospective evaluation of therapeutic outcomes, including overall survival (OS), stent patency rate, complications, and prognostic features, was conducted in 101 patients...
May 7, 2018: Brachytherapy
https://www.readbyqxmd.com/read/29724633/iodine-125-seed-brachytherapy-inhibits-non-small-cell-lung-cancer-by-suppressing-epithelial-mesenchymal-transition
#9
Yana He, Liang Li, Jihua Liu, Xuening Zhang
PURPOSE: Metastatic non-small cell lung cancer (NSCLC) has posed a great clinical challenge with high mortality. Iodine-125 (I-125) seed brachytherapy has not been widely applied in clinic against NSCLC. METHODS AND MATERIALS: Mice were injected with human H23 NSCLC cells to establish a mouse xenograft model, which received I-125 seed implantation. The curative effect, pathological impairments, and survival rate of mice were investigated. Changes in the expression levels of epithelial-mesenchymal transition (EMT) markers, including N-cadherin, E-cadherin, and vimentin, in the xenograft tumors were analyzed using reverse transcription polymerase chain reaction and Western blot...
April 30, 2018: Brachytherapy
https://www.readbyqxmd.com/read/29705049/proficiency-based-cervical-cancer-brachytherapy-training
#10
Sherry Zhao, Louise Francis, Dorin Todor, Emma C Fields
PURPOSE: Although brachytherapy increases the local control rate for cervical cancer, there has been a progressive decline in its use. Furthermore, the training among residency programs for gynecologic brachytherapy varies considerably, with some residents receiving little to no training. This trend is especially concerning given the association between poor applicator placement and decline in local control. Considering the success of proficiency-based training in other procedural specialties, we developed and implemented a proficiency-based cervical brachytherapy training curriculum for our residents...
April 25, 2018: Brachytherapy
https://www.readbyqxmd.com/read/29691149/the-role-of-radiation-therapy-in-the-treatment-of-stage-ii-endometrial-cancer-a-large-database-study
#11
Andrzej P Wojcieszynski, Craig R Hullett, Erin E Medlin, Neil K Taunk, Jacob E Shabason, Jeffrey V Brower, Shuai Chen, Justin E Bekelman, Lisa M Barroilhet, Kristin A Bradley
PURPOSE: The optimum adjuvant treatment for Stage II endometrial cancer patients is unknown. External beam radiation therapy (EBRT) is often considered the standard of care; however, retrospective series suggest that brachytherapy (BT) alone may be sufficient for selected patients. As randomized data are lacking, we used a large database to explore this question. METHODS AND MATERIALS: The National Cancer Data Base was queried for patients with pathologic International Federation of Gynecology and Obstetrics Stage II disease...
April 21, 2018: Brachytherapy
https://www.readbyqxmd.com/read/29681500/moving-toward-uniform-and-evidence-based-practice-of-radiotherapy-for-management-of-cervical-cancer-in-ontario-canada
#12
Negin Shahid, Timothy Craig, Mary Westerland, Allison Ashworth, Michelle Ang, David D'Souza, Raxa Sankreacha, Anthony Fyles, Michael Milosevic, Iwa Kong
PURPOSE: To recognize the practice of radiotherapy for management of cervical cancer in Ontario, Canada, and to use the results of the survey to harmonize and standardize practice across the province. METHODS AND MATERIALS: An electronic survey (SurveyMonkey) was sent to all 14 provincial cancer centers by Cancer Care Ontario Gynecology Community of Practice (CoP) in 2013. The survey included 72 questions in four different categories: general/demographic, pretreatment assessment, external beam radiotherapy (EBRT), and brachytherapy (BT)...
April 19, 2018: Brachytherapy
https://www.readbyqxmd.com/read/29548553/interventional-radiation-oncology-iro-transition-of-a-magnetic-resonance-simulator-to-a-brachytherapy-suite
#13
Roberta Anderson, Elwood Armour, Courtney Beeckler, Valerie Briner, Amanda Choflet, Andrea Cox, Amanda N Fader, Marie N Hannah, Robert Hobbs, Ellen Huang, Marilyn Kiely, Junghoon Lee, Marc Morcos, Paige E McMillan, Dave Miller, Sook Kien Ng, Rashmi Prasad, Annette Souranis, Robert Thomsen, Theodore L DeWeese, Akila N Viswanathan
PURPOSE: As a core component of a new gynecologic cancer radiation program, we envisioned, structured, and implemented a novel Interventional Radiation Oncology (IRO) unit and magnetic resonance (MR)-brachytherapy environment in an existing MR simulator. METHODS AND MATERIALS: We describe the external and internal processes required over a 6-8 month time frame to develop a clinical and research program for gynecologic brachytherapy and to successfully convert an MR simulator into an IRO unit...
March 13, 2018: Brachytherapy
https://www.readbyqxmd.com/read/29525514/new-approach-of-ultra-focal-brachytherapy-for-low-and-intermediate-risk-prostate-cancer-with-custom-linked-i-125-seeds-a-feasibility-study-of-optimal-dose-coverage
#14
Thomas Brun, Jean-Marc Bachaud, Pierre Graff-Cailleaud, Bernard Malavaud, Daniel Portalez, Christian Popotte, Richard Aziza, Amélie Lusque, Thomas Filleron, Soléakhéna Ken
PURPOSE: To present the feasibility study of optimal dose coverage in ultra-focal brachytherapy (UFB) with multiparametric MRI for low- and intermediate-risk prostate cancer. METHODS AND MATERIALS: UFB provisional dose plans for small target volumes (<7 cc) were calculated on a prostate training phantom to optimize the seeds number and strength. Clinical UFB consisted in a contour-based nonrigid registration (MRI/Ultrasound) to implant a fiducial marker at the location of the tumor focus...
March 7, 2018: Brachytherapy
https://www.readbyqxmd.com/read/29519606/a-new-delivery-system-to-resolve-dosimetric-issues-in-intravascular-brachytherapy
#15
Joseph M DeCunha, Shirin A Enger
PURPOSE: Renewed interest is being expressed in intravascular brachytherapy (IVBT). A number of unresolved issues exist in the discipline. Providing a homogeneous and adequate dose to the target remains difficult in IVBT. The guidewire that delivers the device to the target, arterial plaques, and stent struts are all known to reduce the dose delivered to target. The viability and efficacy of a proposed IVBT delivery system designed to resolve the issue of guidewire attenuation is evaluated and compared to that of a popular and commercially available IVBT device...
March 5, 2018: Brachytherapy
https://www.readbyqxmd.com/read/29519605/time-driven-activity-based-cost-comparison-of-prostate-cancer-brachytherapy-and-intensity-modulated-radiation-therapy
#16
Sunil W Dutta, Kristine Bauer-Nilsen, Jason C Sanders, Daniel M Trifiletti, Bruce Libby, Donna H Lash, Melody Lain, Deborah Christodoulou, Constance Hodge, Timothy N Showalter
PURPOSE: To evaluate the delivery cost of frequently used radiotherapy options offered to patients with intermediate- to high-risk prostate cancer using time-driven activity-based costing and compare the results with Medicare reimbursement and relative value units (RVUs). METHODS AND MATERIALS: Process maps were created to represent each step of prostate radiotherapy treatment at our institution. Salary data, equipment purchase costs, and consumable costs were factored into the cost analysis...
March 5, 2018: Brachytherapy
https://www.readbyqxmd.com/read/29496425/endoluminal-high-dose-rate-brachytherapy-for-locally-recurrent-or-persistent-esophageal-cancer
#17
Amandeep S Taggar, Kenneth L Pitter, Gil'ad N Cohen, Mark Schattner, Hans Gerdes, Arnold J Markowitz, David Ilson, Paul Brady, John J Cuaron, Karyn A Goodman, Abraham J Wu
PURPOSE: Management of locally recurrent or persistent esophageal cancer (EC) after standard chemoradiation is challenging. This study updates our experience of treating medically inoperable EC patients with endoluminal high-dose-rate brachytherapy (EHDRBT) including the patients treated with a novel multiballoon channel centering esophageal applicator. METHODS AND MATERIALS: Thirty-three consecutive patients with early-stage primary (n = 7), posttreatment persistent (n = 7), and recurrent (n = 19) EC treated with EHDRBT at our institution were included...
February 26, 2018: Brachytherapy
https://www.readbyqxmd.com/read/29496424/appropriate-timing-for-postimplant-imaging-in-permanent-breast-seed-implant-results-from-a-serial-ct-study
#18
Elizabeth Watt, Leigh Conroy, Michael Peacock, Michael Roumeliotis, Amy Frederick, Siraj Husain, Tyler Meyer
PURPOSE: Postimplant analysis in permanent breast seed implant (PBSI) is performed at inconsistent times subsequent to seed implantation across cancer centers, creating challenges in the interpretation of dosimetric data and ultimately the correlation with clinical outcomes. The purpose of this study is to determine the most appropriate time postimplant to perform this analysis. METHODS AND MATERIALS: Nine patients treated at our institution with PBSI were included in this analysis...
February 26, 2018: Brachytherapy
https://www.readbyqxmd.com/read/29496423/quality-of-life-up-to-10-years-after-external-beam-radiotherapy-and-or-brachytherapy-for-prostate-cancer
#19
Carla Freiberger, Vanessa Berneking, Thomas-Alexander Vögeli, Ruth Kirschner-Hermanns, Michael J Eble, Michael Pinkawa
PURPOSE: The aim of this study was to evaluate quality-of-life changes up to 10 years following three different radiotherapy concepts. METHODS AND MATERIALS: In the years 2000-2003, 295 patients were treated with external beam radiotherapy (EBRT; n = 135; 70.2 Gy in 1.8 Gy fractions), low-dose-rate brachytherapy (LDR-BT with I-125; n = 94; 145 Gy), and high-dose-rate brachytherapy (HDR-BT with Ir-192; n = 66; 18 Gy in two fractions using 4-6 needles) as a boost to EBRT (50...
February 26, 2018: Brachytherapy
https://www.readbyqxmd.com/read/29482918/early-toxicity-and-health-related-quality-of-life-results-of-high-dose-rate-brachytherapy-as-monotherapy-for-low-and-intermediate-risk-prostate-cancer
#20
Marc Gaudet, Mathieu Pharand-Charbonneau, Marie-Pierre Desrosiers, Debbie Wright, Alain Haddad
PURPOSE: To determine the acute toxicity and effect on health-related quality of life of a two-fraction regimen of high-dose-rate (HDR) prostate brachytherapy. METHODS AND MATERIALS: Patients with low- or intermediate-risk prostate cancer were treated with HDR brachytherapy as monotherapy in two implants of 13.5 Gy spaced 7-14 days apart. Patients completed International Prostate Symptom Score (IPSS) and Expanded Prostate Index Composite (EPIC) questionnaires at 1, 3, 6, 9, 12, 16, 20, and 24 months after brachytherapy...
February 23, 2018: Brachytherapy
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