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Brachytherapy

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https://www.readbyqxmd.com/read/28919352/salvage-brachytherapy-for-radiorecurrent-prostate-cancer-searching-for-safety-and-success
#1
EDITORIAL
Max Peters, Marinus A Moerland, Jochem R N van der Voort van Zyp
No abstract text is available yet for this article.
September 14, 2017: Brachytherapy
https://www.readbyqxmd.com/read/28888417/american-brachytherapy-society-recurrent-carcinoma-of-the-endometrium-task-force-patterns-of-care-and-review-of-the-literature
#2
Mitchell Kamrava, Sushil Beriwal, Beth Erickson, David Gaffney, Anuja Jhingran, Ann Klopp, Sang June Park, Akila Viswanathan, Catheryn Yashar, Lilie Lin
PURPOSE: The purpose of this American Brachytherapy Society task force is to present a literature review and patterns of care by a panel of experts for the management of vaginal recurrence of endometrial cancer. METHODS AND MATERIALS: In 2016, the American Brachytherapy Society Board selected a panel of experts in gynecologic brachytherapy to update our current state of knowledge for managing vaginal recurrence of endometrial cancer. Practice patterns were evaluated via an online survey and clinical updates occurred through a combination of literature review and clinical experience and/or expertise...
September 6, 2017: Brachytherapy
https://www.readbyqxmd.com/read/28867617/total-reference-air-kerma-can-accurately-predict-isodose-surface-volumes-in-cervix-cancer-brachytherapy-a-multicenter-study
#3
Karen S Nkiwane, Else Andersen, Jerome Champoudry, Astrid de Leeuw, Jamema Swamidas, Jacob Lindegaard, Richard Pötter, Christian Kirisits, Kari Tanderup
PURPOSE: To demonstrate that V60 Gy, V75 Gy, and V85 Gy isodose surface volumes can be accurately estimated from total reference air kerma (TRAK) in cervix cancer MRI-guided brachytherapy (BT). METHODS AND MATERIALS: 60 Gy, 75 Gy, and 85 Gy isodose surface volumes levels were obtained from treatment planning systems (VTPS) for 239 EMBRACE study patients from five institutions treated with various dose rates, fractionation schedules and applicators. An equation for estimating VTPS from TRAK was derived...
August 31, 2017: Brachytherapy
https://www.readbyqxmd.com/read/28869144/efficiency-of-using-the-day-of-implant-ct-for-planning-of-savi-apbi
#4
Michael B Altman, Karen E Mooney, Sharbacha Edward, Jose L Garcia-Ramirez, Todd A Dewees, Maria A Thomas, Imran Zoberi, Jacqueline E Zoberi
PURPOSE: The purpose of the study was to develop an optimized, efficient workflow for using the day-of-implant (DOI) CT for treatment planning of accelerated partial breast irradiation brachytherapy using the strut-adjusted volume implant (SAVI) device. METHODS AND MATERIALS: For 62 consecutive SAVI patients, a DOI CT was acquired and used for treatment planning. A "verification" CT was acquired 24-72 h after implant and immediately before the first fraction, then registered to the DOI CT...
August 28, 2017: Brachytherapy
https://www.readbyqxmd.com/read/28869143/a-novel-urethral-sparing-technique-for-high-dose-rate-prostate-brachytherapy-after-transurethral-resection-of-the-prostate
#5
Hiroaki Kunogi, Jason Adam M Cunha, Albert J Chang, Adam J Gadzinski, Katsuto Shinohara, I-Chow Hsu
PURPOSE: The purpose of this study was to assess retrospectively the variability of the urethral dose optimized using a Foley catheter versus urethral contrast injected using a new modified triple-lumen catheter, in CT-based high-dose-rate (HDR) prostate brachytherapy of posttransurethral resection of prostate (TURP) patients. METHODS AND MATERIALS: At our institution, there were six post-TURP patients with prostate carcinoma between July 2014 and April 2016 who underwent transperineal interstitial HDR brachytherapy (16 needles)...
August 28, 2017: Brachytherapy
https://www.readbyqxmd.com/read/28844821/low-dose-rate-prostate-brachytherapy-4-8%C3%A2-week-postimplant-prostate-specific-antigen-a-novel-predictor-of-biochemical-failure-free-survival
#6
Cameron M Callaghan, Lin Wang, Abhishek Alluri, Andrew Lauve, Cynthia Boyer, William Russell
PURPOSE: The purpose of this study was to determine the relationship between patient, disease, and treatment variables and biochemical failure-free survival (bFFS) following low-dose-rate prostate brachytherapy (LDR-BT). METHODS AND MATERIALS: Data from 624 consecutive patients who received LDR-BT for localized prostate cancer between 2002 and 2012 at a single institution were collected for various patient, disease, and treatment characteristics including a 4-8 week postimplant PSA (4-8wkPSA)...
August 24, 2017: Brachytherapy
https://www.readbyqxmd.com/read/28844820/clinical-implementation-of-a-novel-double-balloon-single-entry-breast-brachytherapy-applicator
#7
Bethany M Anderson, Charles R Wallace, Anna-Maria A De Costa, Rupak K Das
PURPOSE: The purpose of the study was to describe the clinical utilization of a novel Double-Balloon applicator for accelerated partial breast irradiation (APBI). METHODS AND MATERIALS: The Double-Balloon single-entry breast applicator contains a single central treatment catheter, as well as four peripheral catheters that can be differentially loaded to customize radiation dose coverage. An inner balloon is filled with up to 7-30 cm(3) of saline to increase separation between the peripheral catheters, and an outer balloon is filled with up to 37-115 cm(3) of saline to displace breast tissue from the peripheral catheters...
August 24, 2017: Brachytherapy
https://www.readbyqxmd.com/read/28838649/brachytherapy-attains-abscopal-effects-when-combined-with-immunostimulatory-monoclonal-antibodies
#8
María E Rodriguez-Ruiz, Inmaculada Rodriguez, Benigno Barbes, Lina Mayorga, Alfonso Rodriguez Sanchez-Paulete, Mariano Ponz-Sarvise, José Luis Pérez-Gracia, Ignacio Melero
PURPOSE/OBJECTIVES: Preclinical and clinical evidence indicate that the proimmune effects of radiotherapy can be synergistically augmented with immunostimulatory monoclonal antibodies (mAb) to act both on irradiated tumor lesions and on tumors at distant, nonirradiated sites. We have recently reported that external beam radiotherapy achieves abscopal effects when combined with antagonist anti-PD1 mAbs and agonist anti-CD137 (4-1BB) mAbs. The goal of this work is to study the abscopal effects of radiotherapy instigated by brachytherapy techniques...
August 21, 2017: Brachytherapy
https://www.readbyqxmd.com/read/28838648/salvage-brachytherapy-for-recurrent-prostate-cancer-after-definitive-radiation-therapy-a-comparison-of-low-dose-rate-and-high-dose-rate-brachytherapy-and-the-importance-of-prostate-specific-antigen-doubling-time
#9
Marisa A Kollmeier, Sean McBride, Amandeep Taggar, Erik Anderson, Mary Lin, Xin Pei, Shi Weiji, Laszlo Voros, Gilad Cohen, Yoshiya Yamada, Michael J Zelefsky
BACKGROUND: Salvage brachytherapy is a treatment option for patients with locally recurrent prostate cancer after primary radiation therapy. We reviewed our experience using low-dose-rate (LDR) or high-dose-rate (HDR) brachytherapy to compare the outcome and toxicity profiles of each approach in the salvage brachytherapy setting. METHODS AND MATERIALS: Ninety-eight patients with biopsy-proven locally recurrent prostate cancer who underwent salvage brachytherapy (LDR = 37; HDR = 61) following an initial course of definitive radiotherapy between 4/2003 and 4/2015 were retrospectively reviewed...
August 21, 2017: Brachytherapy
https://www.readbyqxmd.com/read/28827007/failure-modes-and-effects-analysis-for-ocular-brachytherapy
#10
Yongsook C Lee, Yongbok Kim, Jason Wei-Yeong Huynh, Russell J Hamilton
PURPOSE: The aim of the study was to identify potential failure modes (FMs) having a high risk and to improve our current quality management (QM) program in Collaborative Ocular Melanoma Study (COMS) ocular brachytherapy by undertaking a failure modes and effects analysis (FMEA) and a fault tree analysis (FTA). METHODS AND MATERIALS: Process mapping and FMEA were performed for COMS ocular brachytherapy. For all FMs identified in FMEA, risk priority numbers (RPNs) were determined by assigning and multiplying occurrence, severity, and lack of detectability values, each ranging from 1 to 10...
August 18, 2017: Brachytherapy
https://www.readbyqxmd.com/read/28827006/intraoperative-implantation-of-a-mesh-of-directional-palladium-sources-civasheet-dosimetry-verification-clinical-commissioning-dose-specification-and-preliminary-experience
#11
Gil'ad N Cohen, Karen Episcopia, Seng-Boh Lim, Thomas J LoSasso, Mark J Rivard, Amandeep S Taggar, Neil K Taunk, Abraham J Wu, Antonio L Damato
PURPOSE: To present the clinical commissioning of a novel (103)Pd directional brachytherapy device (CivaSheet) for intraoperative radiation therapy. METHODS AND MATERIALS: Clinical commissioning for the CivaSheet consisted of establishing: (1) source strength calibration capabilities, (2) experimental verification of TG-43 dosimetry parameters, (3) treatment planning system validation, and (4) departmental practice for dose specification and source ordering. Experimental verification was performed in water with radiochromic film calibrated with a 37 kVp X-ray beam...
August 18, 2017: Brachytherapy
https://www.readbyqxmd.com/read/28823395/mr-versus-ct-based-high-dose-rate-interstitial-brachytherapy-for-vaginal-recurrence-of-endometrial-cancer
#12
Sophia C Kamran, Matthias M Manuel, Paul Catalano, Linda Cho, Antonio L Damato, Larissa J Lee, Ehud J Schmidt, Akila N Viswanathan
PURPOSE: To compare clinical outcomes of MR-based versus CT-based high-dose-rate interstitial brachytherapy (ISBT) for vaginal recurrence of endometrioid endometrial cancer (EC). METHODS AND MATERIALS: We reviewed 66 patients with vaginal recurrent EC; 18 had MR-based ISBT on a prospective clinical trial and 48 had CT-based treatment. Kaplan-Meier survival modeling was used to generate estimates for local control (LC), disease-free interval (DFI), and overall survival (OS), and multivariate Cox modeling was used to assess prognostic factors...
August 16, 2017: Brachytherapy
https://www.readbyqxmd.com/read/28823394/association-of-bladder-dose-with-late-urinary-side-effects-in-cervical-cancer-high-dose-rate-brachytherapy
#13
Roja Zakariaee, Ghassan Hamarneh, Colin J Brown, Marc Gaudet, Christina Aquino-Parsons, Ingrid Spadinger
PURPOSE: The purpose of this work was to study the association between specific urinary sequelae and locally accumulated dose to the bladder wall and bladder neck in the treatment of cervical cancer with multifraction high-dose-rate (HDR) brachytherapy. METHODS AND MATERIALS: A cohort of 60 cervical cancer patients, treated with both external beam and five HDR brachytherapy insertions between 2008 and 2014 at the BC Cancer Agency, was identified. The accumulated dose received over five brachytherapy sessions was evaluated for the bladder wall and bladder neck of each patient using dosimetric parameters calculated from deformably registered image data sets...
August 16, 2017: Brachytherapy
https://www.readbyqxmd.com/read/28818442/mri-based-treatment-planning-and-dose-delivery-verification-for-intraocular-melanoma-brachytherapy
#14
Jacqueline Esthappan Zoberi, Jose Garcia-Ramirez, Samantha Hedrick, Vivian Rodriguez, Carol G Bertelsman, Stacie Mackey, Yanle Hu, H Michael Gach, P Kumar Rao, Perry W Grigsby
PURPOSE: Episcleral plaque brachytherapy (EPB) planning is conventionally based on approximations of the implant geometry with no volumetric imaging following plaque implantation. We have developed an MRI-based technique for EPB treatment planning and dose delivery verification based on the actual patient-specific geometry. METHODS AND MATERIALS: MR images of 6 patients, prescribed 85 Gy over 96 hours from Collaborative Ocular Melanoma Study-based EPB, were acquired before and after implantation...
August 14, 2017: Brachytherapy
https://www.readbyqxmd.com/read/28807749/high-dose-rate-interstitial-brachytherapy-boost-in-inoperable-locally-advanced-tongue-carcinoma
#15
Miguel Angel Santos, Jose Luis Guinot, Maria Isabel Tortajada, Paula Santamaría, Valentin Campo, Laura Oliver, Marina Peña, Leoncio Arribas
PURPOSE: Locally advanced tongue carcinomas (LATCs) in inoperable lesions are managed with external beam radiation therapy (EBRT) and chemotherapy. In our institution, the boost to the gross tumor volume is delivered with high-dose-rate brachytherapy (HDR-BT) after EBRT. We review the outcome of these patients when HDR-BT is added as a boost. METHODS AND MATERIALS: From May 2000 to December 2014, a total of 24 patients with LATC, nonsurgical oral tongue, and base of tongue carcinomas were treated with EBRT and with interstitial plastic tubes for brachytherapy; median dose was 18-24 Gy in 6-8 fractions after 50-60 Gy of EBRT...
August 11, 2017: Brachytherapy
https://www.readbyqxmd.com/read/28807748/dosimetric-analysis-and-preliminary-clinical-result-of-image-guided-brachytherapy-with-or-without-hybrid-technique-for-cervical-cancer-using-varisource-titanium-ring-applicator-with-siriraj-ring-cap
#16
Pittaya Dankulchai, Suphalerk Lohasammakul, Janjira Petsuksiri, Pitchayut Nakkrasae, Lalida Tuntipumiamorn, Chumpot Kakanaporn, Yaowalak Chansilpa
PURPOSE: Titanium ring cap applicator (VariSource) was applied in treating cervical cancer patients by using image-guided brachytherapy (IGBT). However, its sizes appeared to be relatively large for most of our patients. Thus, we have developed a specific applicator "Siriraj Ring Cap," which is slightly smaller and more suitable for our patients. This study was to evaluate effectiveness of this equipment. METHODS AND MATERIALS: Locally advanced cervical cancer patients were treated with external beam radiation therapy with or without concomitant chemotherapy...
August 11, 2017: Brachytherapy
https://www.readbyqxmd.com/read/28807747/pretreatment-3t-multiparametric-mri-staging-predicts-for-biochemical-failure-in-high-risk-prostate-cancer-treated-with-combination-high-dose-rate-brachytherapy-and-external-beam-radiotherapy
#17
John V Hegde, D Jeffrey Demanes, Darlene Veruttipong, Jagdeep Raince, Sang-June Park, Steven S Raman, Nicholas G Nickols, Christopher R King, Amar U Kishan, Michael L Steinberg, Mitchell Kamrava
PURPOSE: To determine whether pretreatment 3T multiparametric MRI (mpMRI) staging impacts biochemical recurrence-free survival (BRFS) or distant metastasis-free survival (DMFS) for men with high-risk prostate cancer treated with combination high-dose-rate (HDR) brachytherapy and external beam radiation therapy (EBRT). MATERIALS AND METHODS: This institutional review board-approved retrospective study included a cohort of 37 men with high-risk prostate cancer treated with HDR brachytherapy and EBRT after 3T mpMRI...
August 11, 2017: Brachytherapy
https://www.readbyqxmd.com/read/28802913/salvage-high-dose-rate-brachytherapy-and-external-beam-radiotherapy-for-isolated-vaginal-recurrences-of-endometrial-cancer-with-no-prior-adjuvant-therapy
#18
Christopher H Chapman, Kaveh Maghsoudi, Ramey D Littell, Lee-May Chen, I-Chow Hsu
PURPOSE: To evaluate clinical outcomes for isolated vaginal recurrence of endometrial cancer without adjuvant therapy treated with salvage external beam radiation therapy (EBRT) and high-dose-rate CT-based inverse-planned brachytherapy. METHODS AND MATERIALS: Thirty women were included in this retrospective study. Median time to first recurrence was 16.7 months, and median age at recurrence was 73 years. Initial grade was 1 or 2 in 19 patients (63%), and 2009 FIGO stage IA in 19 patients...
August 9, 2017: Brachytherapy
https://www.readbyqxmd.com/read/28801116/comparative-results-of-three-short-brachytherapy-schedules-as-exclusive-treatment-in-postoperative-endometrial-carcinoma
#19
Ángeles Rovirosa, Antonio Herreros, Cristina Camacho, Carlos Ascaso, Joan Sánchez, Stepphania Cortés, Sebastià Sabater, Jordi Solà, Aureli Torné, Meritxell Arenas
PURPOSE: To compare vaginal control and treatment toxicity of three different high-dose-rate brachytherapy schedules as exclusive treatment in postoperative endometrial carcinoma. METHODS AND MATERIALS: From 2003 to 2015, three different schedules were used as postoperative treatment for 146 patients (p) with intermediate-risk endometrial carcinoma. Group 1 (41 p): six fractions of 4-6 Gy, 3-4 fractions per week; Group 2 (59 p): four fractions of 5-6 Gy administered daily; Group 3 (46 p): 6 Gy × 3 fractions in three consecutive days...
August 8, 2017: Brachytherapy
https://www.readbyqxmd.com/read/28801115/incidence-and-prediction-of-seed-migration-to-the-chest-after-iodine-125-brachytherapy-for-hepatocellular-carcinoma
#20
Junqing Lin, Weizhu Yang, Na Jiang, Qubin Zheng, Jingyao Huang, Ning Huang, Ang Li, Han Jiang
PURPOSE: The aims were to determine the incidence of seed migration to the chest and to analyze the predictive factors after iodine-125 brachytherapy for hepatocellular carcinoma. METHODS AND MATERIALS: Three hundred ninety-nine patients with hepatocellular carcinoma underwent iodine-125 seed brachytherapy. After seed implantation, chest X-ray radiograph or computerized tomography were undertaken to assess the occurrence and location of seed migration at 3 months after brachytherapy...
August 8, 2017: Brachytherapy
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