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Sara Abdollahi, Mahdieh Dayyani, Elie Hoseinian-Azghadi, Hashem Miri-Hakimabad, Laleh Rafat-Motavalli
PURPOSE: Although the dosimetric characterization of 60 Co BEBIG source can be found in several literature studies, the data sets show major discrepancies and the lack of uncertainty analyses. This study tried to determine an accurate dosimetric data set for this source using Monte Carlo (MC) simulations along with detailed uncertainty analysis. To explore how different dosimetric data sets can make changes in practical situations, clinical dose distributions based on our results were compared with the dose distributions derived from Granero et al...
September 15, 2018: Brachytherapy
Denisa Pohanková, Igor Sirák, Pavel Jandík, Linda Kašaova, Jakub Grepl, Motyčka Petr, Asqar Ahmed, Paluska Petr, Vladimír Ninger, Ivana Bydžovská, Viliam Kopecky, Jiří Petera
PURPOSE: To assess the feasibility of high-dose-rate perioperative multicatheter interstitial brachytherapy to deliver accelerated partial breast irradiation (APBI) in selected patients with early breast cancer. METHODS AND MATERIALS: Perioperative multicatheter interstitial brachytherapy for APBI has been used at our department since 2012 for patients with low-risk breast cancer. Interstitial catheters were inserted perioperatively via hollow needles immediately following tumorectomy with sentinel node biopsy...
September 15, 2018: Brachytherapy
Karina Nieto, Brendan Martin, Nghia Pham, Laura Palmere, Scott R Silva, Abigail Winder, Margaret Liotta, Ronald K Potkul, William Small, Matthew M Harkenrider
PURPOSE: To compare radiation toxicity in endometrial cancer patients treated with adjuvant vaginal brachytherapy (VBT) vs. VBT with concurrent chemotherapy (CCT) or sequential chemotherapy (SCT) METHODS: We retrospectively analyzed 131 patients with endometrial cancer treated with VBT without external beam radiation therapy. Toxicities were graded according to the Common Terminology Criteria for Adverse Events v4.03. CCT was defined as VBT delivered between the first and last cycle of chemotherapy (CT); SCT was defined as VBT delivered before or after CT...
September 15, 2018: Brachytherapy
Diane C Ling, Pooja Karukonda, Ryan P Smith, Dwight E Heron, Sushil Beriwal
PURPOSE: Although external beam radiation therapy (EBRT) plus a brachytherapy boost (BB) offers a 20% improvement in biochemical progression-free survival compared with dose-escalated EBRT alone for men with intermediate and high-risk prostate cancer, population studies show a concerning decline in BB utilization. METHODS: We modified our clinical pathway (CP) in January 2016 to indicate EBRT with BB as first-choice modality for high-risk prostate cancer, based on preliminary findings of Androgen Suppression Combined with Elective Nodal and Dose-Escalated Radiation Therapy...
September 11, 2018: Brachytherapy
Samantha A M Lloyd, Douglas A Rahn, Jeremy D P Hoisak, Irena Dragojević
PURPOSE: To evaluate changes in the percent depth dose (PDD) and effective depth of treatment due to force applied by the applicator during treatments of nonmelanoma skin cancer with the Xoft electronic brachytherapy system. METHODS: To simulate compressible tissue, a 5-mm tissue-equivalent bolus was used. A soft x-ray ion chamber was used for output measurements, which were performed for all Xoft surface applicators with plastic endcaps in place. Output was first measured at 5 mm depth with minimal pressure from the applicator on the bolus and then repeated after applying uniform pressure on the applicator to calculate the change in PDD and effective treatment depth...
September 11, 2018: Brachytherapy
Junghoon Lee, Robert F Hobbs, Marianna Zahurak, Sook Kien Ng, Zhe Zhang, E Clif Burdette, Theodore L DeWeese, Daniel Y Song
PURPOSE: To assess the performance of a system of intraoperative dosimetry and obtain estimates of dosimetry outcomes achieved when utilizing the system in a Phase II clinical trial. METHODS AND MATERIALS: Forty-five patients undergoing permanent Pd-103 seed implantation for prostate cancer were prospectively enrolled. Seed implantation was performed and dose was tracked intraoperatively using intraoperative registered ultrasound and fluoroscopy (iRUF). Three-dimensional seed locations were computed from X-rays and registered to ultrasound for intraoperative dosimetry, followed by adaptive plan modification to achieve prostate V100 ≥95% and ≥95% D90...
September 11, 2018: Brachytherapy
Kibrom Berihu Girum, Alain Lalande, Magali Quivrin, Igor Bessières, Noelle Pierrat, Etienne Martin, Luc Cormier, Aurélie Petitfils, Jean Marc Cosset, Gilles Créhange
PURPOSE: To evaluate the dose distribution of additional radioactive seeds implanted during salvage permanent prostate implant (sPPI) after a primary permanent prostate implant (pPPI). METHODS AND MATERIALS: Patients with localized prostate cancer were primarily implanted with iodine-125 seeds and had a dosimetric assessment based on day 30 postimplant CT (CT1). After an average of 6 years, these patients underwent sPPI followed by the same CT-based evaluation of dosimetry (CT2)...
September 11, 2018: Brachytherapy
Sebastia Sabater, Ignacio Andres, Veronica Lopez-Honrubia, Maria Magdalena Marti-Laosa, Susana Castro-Larefors, Roberto Berenguer, Esther Jimenez-Jimenez, Marimar Sevillano, Angeles Rovirosa, Meritxell Arenas
Endometrial cancer is the most common gynecological cancer in developed countries. Postoperative irradiation has been shown to lower locoregional relapses among high-intermediate risk endometrial cancer patients. In addition, vaginal cuff brachytherapy has demonstrated similar control to external beam radiotherapy but with lower toxicity. Although randomized trials have failed to translate that into better overall survival, reports from large databases, such as the National Cancer Database and the Surveillance, Epidemiology, and End Results database, have shown evidence of a statistical relationship between postoperative irradiation and survival in the intermediate- and high-risk groups...
September 3, 2018: Brachytherapy
Habib Safigholi, Bob van Veelen, Yury Niatsetski, William Y Song
PURPOSE: The direction modulated brachytherapy (DMBT) magnetic resonance-compatible tandem applicator, made from a tungsten alloy rod, has six symmetric peripheral grooves, designed specifically to enhance intensity modulation capacity through achieving directional radiation dose profiles. In this work, the directional dose distributions of the DMBT tandem were modeled and calculated with the Oncentra Brachy advanced collapsed cone engine (ACE), which was validated against Monte Carlo (MC) calculations...
September 1, 2018: Brachytherapy
J Charret, A S Baumann, P Eschwege, J L Moreau, V Bernier, A T Falk, J Salleron, D Peiffert
PURPOSE: The only prognostic factor of prostate-specific antigen (PSA) bounce in prostate cancer found in several studies is young age but has never been specifically studied in this subset of patients for long-term results. Bounce characteristics, histological, clinical, and dosimetric data in young patients were analyzed, as well as their impact on toxicity and survival. MATERIAL AND METHODS: This retrospective study included patients aged ≤60 years treated with exclusive iodine 125 brachytherapy with low or intermediary prostate adenocarcinoma during 1999-2014...
August 29, 2018: Brachytherapy
Valentina Lancellotta, Ludwing Seipelt, Jean-Michelle Hannoun-Levi, Luca Tagliaferri, Marie-Eve Chand, Elisabetta Perrucci, Vincenzo Valentini, Cynthia Aristei, Gyoergy Kovács, Tamer Soror
PURPOSE: The aim of the present work is to assess the Objective Breast Cosmesis Scale (OBCS) in a patient cohort that was treated in two hospitals. Their treatment-related cosmetic changes were recorded on nonstandardized photographs. METHODS AND MATERIALS: Nineteen female patients were enrolled in two radiation oncology centers (Nice, France, and Perugia, Italy). All patients had undergone breast-conserving surgery (BCS) and received adjuvant accelerated partial breast irradiation using interstitial fractionated multicatheter high-dose-rate brachytherapy...
August 24, 2018: Brachytherapy
Matthew D Belley, Oana Craciunescu, Zheng Chang, Brian W Langloss, Ian N Stanton, Terry T Yoshizumi, Michael J Therien, Junzo P Chino
PURPOSE: A nanoscintillator-based fiber-optic dosimeter (nanoFOD) was developed to measure real-time dose rate during high-dose-rate (HDR) brachytherapy. A trial was designed to prospectively test clinical feasibility in gynecologic implants. METHODS AND MATERIALS: A clinical trial enrolled women undergoing vaginal cylinder HDR brachytherapy. The nanoFOD was fixed to the cylinder alongside two thermoluminescent dosimeters (TLDs). Treatment was delivered and real-time dose rates captured by the nanoFOD...
August 24, 2018: Brachytherapy
Manuj Agarwal, Arpit M Chhabra, Neha Amin, Michelle H Braccioforte, Jason K Molitoris, Brian J Moran
PURPOSE: The available data demonstrating that superiority of LDR brachytherapy (LDR-BT) boost in high-risk prostate cancer patients under represents patients with extracapsular extension (T3a) and/or seminal vesicle invasion (T3b) have been limited. We report long-term clinical outcomes data for patients with cT3a/b disease receiving LDR-BT. METHODS AND MATERIALS: Ninety-nine men (median age: 69.4 years) with cT3a/bN0M0 high-risk prostate adenocarcinoma received definitive LDR-BT or LDR-BT boost after external beam radiation therapy (EBRT) at a single institution between 1998 and 2007...
August 21, 2018: Brachytherapy
Joel Thomas, Arpan V Prabhu, Dwight E Heron, Sushil Beriwal
PURPOSE: Twitter may reflect attitudes underrepresented in traditional surveys. This study aimed to understand professionals' and patients' thoughts regarding brachytherapy on Twitter. METHODS AND MATERIALS: Twitter was queried with "brachytherapy" to identify all tweets about patients' experiences from January 2012 to May 2017. A random sample of tweets by health care professionals containing "brachytherapy" was obtained using the first weekly tweet in the same interval...
August 18, 2018: Brachytherapy
Murillo Bellezzo, Gabriel P Fonseca, An-Sofie Verrijssen, Robert Voncken, Michiel R Van den Bosch, Hélio Yoriyaz, Brigitte Reniers, Maaike Berbée, Evert J Van Limbergen, Frank Verhaegen
PURPOSE: Dose escalation to rectal tumors leads to higher complete response rates and may thereby enable omission of surgery. Important advantages of endoluminal boosting techniques include the possibility to apply a more selective/localized boost than using external beam radiotherapy. A novel brachytherapy (BT) rectal applicator with lateral shielding was designed to be used with a rectoscope for eye-guided positioning to deliver a dose distribution similar to the one of contact x-ray radiotherapy devices, using commonly available high-dose-rate 192 Ir BT sources...
August 16, 2018: Brachytherapy
Daniel Moore Freitas Palhares, Daniel Grossi Marconi, Tatiana Leitão de Azevedo, Clayton Burnett Hess, José Humberto Tavares Guerreiro Fregnani, Renato José Affonso, Ana Carolina Lima Chaves Veneziani, Heloisa Pelisser Canton, Rodrigo Gadia, Marcelo Dimas Spadim, Rodrigo Ribeiro Rossini, Mitchell Kamrava
PURPOSE: To identify if baseline patient or magnetic resonance imaging (MRI) features can predict which women are at risk for inadequate tumor coverage with only intracavitary tandem and ovoid (T + O) brachytherapy and to correlate tumor coverage with clinical outcomes. METHODS AND MATERIALS: We performed a retrospective study of 50 women with cervical cancer treated with chemoradiation at a single institution between January 2014 and December 2015. All patients had a 3T-MRI performed at baseline (MRI1) and at the completion of external beam radiation therapy (MRI2)...
August 9, 2018: Brachytherapy
Assaf Moore, Mordechai R Kramer, David Silvern, Osnat Shtraichman, Aaron M Allen
PURPOSE: Airway amyloidosis is an uncommon condition and may have variable clinical course. There is no proven systemic therapy, and the management mainly relies on local invasive treatments. Several reports have found external beam radiotherapy to produce durable responses. The optimal dose and fractionation has not been determined. Endobronchial brachytherapy (EBB) has never been reported to affect this disease. METHODS: The study includes a retrospective chart review of all patients with airway amyloidosis treated with EBB at the Davidoff Cancer Center...
August 3, 2018: Brachytherapy
Bao Han A Le, Jonathan W Kim, Hao Deng, Nadim Rayess, Richard L Jennelle, Sue Y Zhou, Melvin A Astrahan, Jesse L Berry
PURPOSE: To review long-term outcomes of the University of Southern California Plaque Simulator (PS) software and Eye Physics (EP) plaques. We hypothesize that the PS/EP system delivers lower doses to critical ocular structures, resulting in lower rates of radiation toxicity and favorable visual outcomes compared to Collaborative Ocular Melanoma Study plaques, while maintaining adequate local tumor control. METHODS AND MATERIALS: Retrospective review of 133 patients treated for choroidal melanoma with 125 I brachytherapy, using PS software and EP plaques, from 1990 through 2015...
August 3, 2018: Brachytherapy
Ravi B Patel, Claire C Baniel, Raghava N Sriramaneni, Kristin Bradley, Stephanie Markovina, Zachary S Morris
As immunotherapies continue to emerge as a standard component of treatment for a variety of cancers, the imperative for testing these in combination with other standard cancer therapies grows. Radiation therapy may be a particularly well-suited partner for many immunotherapies. By modulating immune tolerance and functional immunogenicity at a targeted tumor site, radiation therapy may serve as a method of in situ tumor vaccination. In situ tumor vaccination is a therapeutic strategy that seeks to convert a patient's own tumor into a nidus for enhanced presentation of tumor-specific antigens in a way that will stimulate and diversify an antitumor T cell response...
August 2, 2018: Brachytherapy
Charles C Vu, Kevin G Blas, Thomas B Lanni, Gary S Gustafson, Daniel J Krauss
PURPOSE: The recently published ASCENDE-RT randomized clinical trial demonstrated improved biochemical control, albeit with increased toxicity, for a prostate boost with brachytherapy versus external beam radiation therapy alone in patients with intermediate-high risk prostate cancer. In this study, we investigated the cost-effectiveness of these two modalities in the treatment of intermediate-high risk prostate cancer. METHODS AND MATERIALS: A multistate Markov model was created to model a patient with intermediate-high risk prostate cancer...
July 31, 2018: Brachytherapy
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