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I Rivero-Belenchón, I Osmán-García, C B Congregado-Ruíz, P Cabrera-Roldán, M J Jiménez-Torres, M Baeza-Trujillo, G Lendínez-Cano, J M Conde-Sánchez, E Argüelles-Salido, M J Ortiz-Gordilo, R A Medina-López
PURPOSE: Prostate cancer (PCa) is the most common malignancy among men and one of the most common neoplasms affecting renal transplant recipients (RTRs). The available treatments for localized PCa among the general population (GP), surgery and external beam radiotherapy, carry a risk of damage to the transplanted kidney, the ureters, and the bladder and therefore tend to be avoided by most groups. The objective of this study was to assess the efficacy and feasibility of low-dose-rate brachytherapy (LDR-BT) for PCa in RTRs...
June 30, 2018: Brachytherapy
Matthew M Harkenrider, Rakesh Patel, Murat Surucu, Bonnie Chinsky, Michael L Mysz, Abbie Wood, Kelly Ryan, Steven M Shea, William Small, John C Roeske
PURPOSE/OBJECTIVE(S): To evaluate dosimetric differences between MRI-only and MRI-CT planning with a titanium tandem and ovoid applicator to determine if all imaging and planning goals can be achieved with MRI only. MATERIALS/METHODS: We evaluated 10 patients who underwent MRI-CT-based cervical brachytherapy with a titanium tandem and ovoid applicator. High-risk clinical target volume and organs at risk were contoured on the 3D T2 MRI, which were transferred to the co-registered CT, where the applicator was identified...
June 23, 2018: Brachytherapy
Franziska Walter, Cornelius Maihöfer, Lars Schüttrumpf, Justus Well, Alexander Burges, Birgit Ertl-Wagner, Sven Mahner, Claus Belka, Julia Gallwas, Stefanie Corradini
PURPOSE: To report on first-in-human experience and the initial clinical results using the hybrid applicator Venezia (Elekta, Sweden) in the treatment of patients with locally advanced cervical cancer. MATERIAL AND METHODS: Between March, 2017, and February, 2018, a total of 40 fractions were performed on patients undergoing definitive chemoradiation and brachytherapy (BT) for cervical cancer. A plan comparison was conducted evaluating the hybrid applicator with the clinically used intracavitary and interstitial (IC/IS) BT against a standard plan prescribed to Point A and a manually optimized plan using only intracavitary (IC) BT...
June 22, 2018: Brachytherapy
Joel Poder, Ryan Brown, Andrew Howie, Johnson Yuen, Anna Ralston, Kristine Schreiber, Andrej Bece, Joseph Bucci
PURPOSE: The purpose of this study was to apply a risk-based approach to the development of a quality management (QM) program for ultrasound-based high-dose-rate (HDR) prostate brachytherapy (pBT) treatment planning and delivery. METHODS AND MATERIALS: A QM program was developed by a multidisciplinary team, using both an in-house risk-and-benefit balance impact template (RABBIT) tool and a failure modes and effect analysis (FMEA). FMEA scores were determined by three physicists, one radiation therapist and two radiation oncologists who were familiar with the protocol...
June 21, 2018: Brachytherapy
Jaroslaw T Hepel, Catheryn Yashar, Kara L Leonard, John P Einck, Sandra Sha, Thomas DiPetrillo, Doreen Wiggins, Theresa A Graves, David Edmonson, David E Wazer
PURPOSE: To improve efficiency, convenience, and cost, a prospective phase II trial was initiated to evaluate accelerated partial breast irradiation delivered with noninvasive image-guided breast brachytherapy (NIBB) via five once-daily fractions. METHODS AND MATERIALS: Women ≥50 years old with early-stage breast cancer undergoing breast conserving surgery were enrolled. Eligibility criteria included invasive carcinoma ≤2.0 cm or ductal carcinoma in situ ≤3...
June 20, 2018: Brachytherapy
Jean-Baptiste Coquet, Francky Delage, Alexandre Fourcade, Pierre Callerot, Gaelle Goasduff, Nicolas Boussion, Benoit Rousseau, Sophie Serey-Eiffel, Jean-Pierre Malhaire, Olivier Pradier, Ulrike Schick, Georges Fournier, Antoine Valeri
PURPOSE: "Quadrella" index has been recently developed to assess oncological and functional outcomes after prostate brachytherapy (PB). We aimed to evaluate this index at 1, 2, and 3 years, using validated questionnaires, assessed prospectively. METHODS AND MATERIALS: From 08/2007 to 01/2013, 193 patients underwent 125 Iodine PB for low-risk or favorable intermediate-risk prostate adenocarcinoma. Inclusion criteria were as follows: no incontinence (International Continence Society Index initial score = 0) and good erectile function (International Index of Erectile Function-5 items: >16)...
June 20, 2018: Brachytherapy
Tomoki Tanaka, Atsunori Yorozu, Shinya Sutani, Yasuto Yagi, Toru Nishiyama, Yutaka Shiraishi, Toshio Ohashi, Takashi Hanada, Shiro Saito, Kazuhito Toya, Naoyuki Shigematsu
PURPOSE: We analyzed factors associated with rectal toxicity after iodine-125 prostate brachytherapy (BT) with or without external beam radiation therapy (EBRT). METHODS AND MATERIALS: In total, 2216 prostate cancer patients underwent iodine-125 BT with or without EBRT between 2003 and 2013. The median followup was 6.9 years. Cox proportional hazards modeling was used for univariate and multivariate analyses to assess clinical and dosimetric factors associated with rectal toxicity...
June 20, 2018: Brachytherapy
Ernestas Janulionis, Vitalija Samerdokiene, Konstantinas Povilas Valuckas, Vydmantas Atkocius, Mark J Rivard
PURPOSE: Second primary malignancies (SPMs) may occur in organs after radiotherapy (RT). This study aimed to determine the rate and distribution of SPMs for photon- or neutron-emitting radiotherapy sources for patients treated for primary endometrial cancer. METHODS AND MATERIALS: The cohort comprised 426 patients with 5334 patient-years of observation. Patients were treated by different methods of RT from 1990 to 2000. Patients received postoperative 60 Co external-beam radiotherapy (43...
June 9, 2018: Brachytherapy
Jeremiah W Sanders, Hao Song, Steven J Frank, Tharakeswara Bathala, Aradhana M Venkatesan, Mitchell Anscher, Chad Tang, Teresa L Bruno, Wei Wei, Jingfei Ma
PURPOSE: To investigate the feasibility of using parallel imaging compressed sensing (PICS) to reduce scan time and improve signal-to-noise ratio (SNR) in MRI-based postimplant dosimetry of prostate brachytherapy. METHODS AND MATERIALS: Ten patients underwent low-dose-rate prostate brachytherapy with radioactive seeds stranded with positive magnetic resonance-signal seed markers and were scanned on a Siemens 1.5T Aera. MRI comprised a fully balanced steady-state free precession sequence with two 18-channel external pelvic array coils with and without a rigid two-channel endorectal coil...
June 4, 2018: Brachytherapy
Rajni Sethi, Yueh Chun Kuo, Babak Edraki, Dimitry Lerner, Daniel Paik, William Bice
PURPOSE: Doppler ultrasound (US) gives real-time information regarding anatomy and blood vessel location to guide needle placement for gynecologic interstitial (IS) brachytherapy (BT). We retrospectively assessed Doppler US images for vessel quantity, size, and distribution in cervical cancer patients undergoing high-dose-rate BT at our institution. METHODS AND MATERIALS: Eleven consecutive patients undergoing IS high-dose-rate BT implants for cervical cancer between 2015 and 2017 were included...
May 31, 2018: Brachytherapy
Hayeon Kim, Christopher J Houser, Ronny Kalash, Carly A Maceil, Brett Palestra, Deborah Malush, Sushil Beriwal
PURPOSE: We report the clinical workflow and time required for MRI-based image-guided brachytherapy (MR-IGBT) of cervical cancer patients in a high-volume brachytherapy center with 10 years of experiences to provide a practical guideline for implementing MR-IGBT into clinical use. METHODS AND MATERIALS: We recorded the time and workflow of each procedure step within the 40 consecutive ring and tandem applicator fractions of MR-IGBT by our multidisciplinary team...
May 26, 2018: Brachytherapy
Andrew J Frankart, Teresa Meier, Thomas L Minges, Jordan Kharofa
PURPOSE: To evaluate the impact of general versus spinal anesthesia on postprocedure narcotic use and of extradepartmental planning MRI on treatment time in high-dose-rate brachytherapy for cervical cancer. METHODS AND MATERIALS: Twenty-five patients (10 general anesthesia and 15 spinal anesthesia) who collectively received 96 brachytherapy fractions (39 general and 57 spinal) for cervical cancer between February 2015 and April 2017 were retrospectively reviewed...
May 25, 2018: Brachytherapy
Rafael Martínez-Monge, Germán Valtueña Peydró, Mauricio Cambeiro, José Manuel Aramendía, Marta Gimeno, Marta Santisteban, Fernando Lecanda, Jose Angel Minguez, Juan L Alcázar, Matías Jurado
PURPOSE: To determine the long-term results of a Phase II trial of perioperative high-dose-rate brachytherapy (PHDRB) in primary advanced or recurrent gynecological cancer. METHODS AND MATERIALS: Fifty patients with locally advanced and recurrent gynecological cancer suitable for salvage surgery were included. Unirradiated patients (n = 25) received preoperative chemoradiation followed by surgery and PHDRB (16-24 Gy). Previously irradiated patients (n = 25) received surgery and PHDRB alone (32-40 Gy)...
May 23, 2018: Brachytherapy
Sherry Zhao, Louise Francis, Dorin Todor, Emma C Fields
PURPOSE: Although brachytherapy increases the local control rate for cervical cancer, there has been a progressive decline in its use. Furthermore, the training among residency programs for gynecologic brachytherapy varies considerably, with some residents receiving little to no training. This trend is especially concerning given the association between poor applicator placement and decline in local control. Considering the success of proficiency-based training in other procedural specialties, we developed and implemented a proficiency-based cervical brachytherapy training curriculum for our residents...
April 25, 2018: Brachytherapy
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No abstract text is available yet for this article.
July 2018: Brachytherapy
Christopher L Deufel, John P Mullins, Mark J Zakhary
PURPOSE: Nasobiliary high-dose-rate (HDR) brachytherapy has emerged as an effective tool to boost the radiation dose for patients with unresectable perihilar cholangiocarcinoma. This work describes a quality assurance (QA) tool for measuring the HDR afterloader's performance, including the transit dose, when the source wire travels through a tortuous nasobiliary catheter path. METHODS AND MATERIALS: The nasobiliary QA device was designed to mimic the anatomical path of a nasobiliary catheter, including the nasal, stomach, duodenum, and bile duct loops...
July 2018: Brachytherapy
Christopher L Deufel, Keith M Furutani, Robert A Dahl, Michael P Grams, Luke B McLemore, Christopher L Hallemeier, Michelle Neben-Wittich, James A Martenson, Michael G Haddock
PURPOSE: Cholangiocarcinoma patients who are potential candidates for liver transplantation may be treated with high-dose-rate (HDR) brachytherapy using a minimally invasive nasobiliary catheter in an effort to escalate the radiotherapy dose to the tumor and maximize local control rates. This work describes the equipment, procedures, and quality assurance (QA) that enables successful administration. METHODS AND MATERIALS: This work describes the nasobiliary catheter placement, simulation, treatment planning, treatment delivery, and QA...
July 2018: Brachytherapy
Huaising C Ko, Jessie Y Huang, Jessica R Miller, Rupak K Das, Charles R Wallace, Anna-Maria A De Costa, David M Francis, Margaret R Straub, Bethany M Anderson, Kristin A Bradley
PURPOSE: To characterize image quality and feasibility of using ViewRay MRI (VR)-guided brachytherapy planning for cervical cancer. METHODS AND MATERIALS: Cervical cancer patients receiving intracavitary brachytherapy with tandem and ovoids, planned using 0.35T VR MRI at our institution, were included in this series. The high-risk clinical target volume (HR-CTV), visible gross tumor volume, bladder, sigmoid, bowel, and rectum contours for each fraction of brachytherapy were evaluated for dosimetric parameters...
July 2018: Brachytherapy
Ryan Manger, Douglas Rahn, Jeremy Hoisak, Irena Dragojević
PURPOSE: To develop an improved Xoft electronic skin brachytherapy process and identify areas of further improvement. METHODS AND MATERIALS: A multidisciplinary team conducted a failure modes and effects analysis (FMEA) by developing a process map and a corresponding list of failure modes. The failure modes were scored for their occurrence, severity, and detectability, and a risk priority number (RPN) was calculated for each failure mode as the product of occurrence, severity, and detectability...
July 2018: Brachytherapy
Agnieszka Zolciak-Siwinska, Adam Kowalczyk, Katarzyna Sikorska, Michal Bijok, Wojciech Michalski, Ewelina Gruszczynska
PURPOSE: To compare CT- and MRI-based brachytherapy (BT) target volumes for patients with advanced cervical cancer so as to identify those who benefit most from MRI-based planning. We also studied how the natural mobility of the organ at risks (OARs) affects the given doses. METHODS AND MATERIALS: Subjects were 60 patients with International Federation of Gynecology and Obstetrics (FIGO) Stage IB-IVA cervical cancer. The CT high-risk clinical target volume (HR-CTV) was first delineated, then the MRI HR-CTV, with volume discrepancies calculated by subtraction...
July 2018: Brachytherapy
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