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Immune Network

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https://www.readbyqxmd.com/read/29303155/erratum-plasmacytoid-dendritic-cells-contribute-to-the-protective-immunity-induced-by-intranasal-treatment-with-fc-fused-interleukin-7-against-lethal-influenza-virus-infection
#1
Moon Cheol Kang, Han Wook Park, Dong-Hoon Choi, Young Woo Choi, Yunji Park, Young Chul Sung, Seung-Woo Lee
[This corrects the article on p. 343 in vol. 17, PMID: 29093655.].
December 2017: Immune Network
https://www.readbyqxmd.com/read/29302257/elisa-for-quantitative-determination-of-hepatitis-b-virus-surface-antigen
#2
Se-Ho Kim
Several studies have reported a good correlation between levels of serum hepatitis B virus surface antigen (HBsAg) and covalently closed circular DNA (cccDNA) before and after antiviral therapy. As a result, the quantification of HBsAg levels has attracted much attention in recent years as an important approach to evaluate viral activity. In this study, mAbs against HBsAg were generated and 9 mAbs (H17, H30, H31, H67, H73, H97, H101, H118, and H128) were investigated for optimization of HBsAg quantitation ELISA...
December 2017: Immune Network
https://www.readbyqxmd.com/read/29302256/heterogeneous-nuclear-ribonucleoprotein-a2b1-exerts-a-regulatory-role-in-lipopolysaccharide-stimulated-38b9-b-cell-activation
#3
Jisang Park, Chung-Hyeon Choe, Ju Kim, Jing Shian Yang, Jin Hyun Kim, Hyonseok Jang, Yong-Suk Jang
Major histocompatibility complex (MHC) class II molecules, which are recognized for their primary function of presenting an antigen to the T cell receptor, are involved in various signaling pathways in B cell activation. We identified heterogeneous nuclear ribonucleoprotein (hnRNP) A2B1 as an MHC class II molecule-associated protein involved in MHC class II-mediated signal transduction in lipopolysaccharide (LPS)-stimulated 38B9 B cells. Although the function of hnRNP A2B1 in the nucleus is primarily known, the level of hnRNP A2B1 in the cytoplasm was increased in LPS-stimulated 38B9 cells, while it was not detected in the cytoplasm of non-treated 38B9 cells...
December 2017: Immune Network
https://www.readbyqxmd.com/read/29302255/species-specific-antiviral-activity-of-porcine-interferon-%C3%AE-8-ifn%C3%AE-8
#4
Eunhye Kim, Hyunjhung Jhun, Joohee Kim, Unjoo Park, Seunghyun Jo, Areum Kwak, Sinae Kim, Tam T Nguyen, Yongsun Kang, Insoo Choi, Joongbok Lee, Heijun Kim, Younghyun Kim, Siyoung Lee, Soohyun Kim
Interferons (IFNs) have been known as antiviral genes and they are classified by type 1, type 2, and type 3 IFN. The type 1 IFN consists of IFNα, IFNβ, IFNτ, and IFNω whereas the type 2 IFN consists of only IFNγ, which is a key cytokine driving T helper cell type 1 immunity. IFNλ belongs to the type 3 IFN, which is also known as IL-28 and IL-29 possessing antiviral activities. Type 1 IFN is produced by viral infection whereas type 2 IFN is induced by mitogenic or antigenic T-cell stimuli. The IFNτ of bovine was first discovered in an ungulate ruminant recognition hormone...
December 2017: Immune Network
https://www.readbyqxmd.com/read/29302254/terminally-differentiating-eosinophils-express-neutrophil-primary-granule-proteins-as-well-as-eosinophil-specific-granule-proteins-in-a-temporal-manner
#5
Karam Kim, Sae Mi Hwang, Sung Min Kim, Sung Woo Park, Yunjae Jung, Il Yup Chung
Neutrophils and eosinophils, 2 prominent granulocytes, are commonly derived from myelocytic progenitors through successive stages in the bone marrow. Our previous genome-wide transcriptomic data unexpectedly showed that genes encoding a multitude of neutrophil primary granule proteins (NPGPs) were markedly downregulated during the end period of eosinophilic terminal differentiation when cord blood (CB) cluster of differentiation (CD) 34+ cells were induced to differentiate toward the eosinophil lineage during a 24-day culture period...
December 2017: Immune Network
https://www.readbyqxmd.com/read/29302253/polyvinylidene-fluoride-alters-inflammatory-responses-by-activation-induced-cell-death-in-macrophages
#6
Hyun Gyung Kim, Sang Hoon Kim, Taek-Seung Kim, Tae Won Park, Ran Won, Hee-Deung Park, Soo An Choi, Yong Woo Jung
Carbon nanotubes (CNTs) are nanomaterials that have been employed in generating diverse materials. We previously reported that CNTs induce cell death in macrophages, possibly via asbestosis. Therefore, we generated CNT-attached polyvinylidene fluoride (PVDF), which is an established polymer in membrane technology, and then examined whether CNT-attached PVDF is immunologically safe for medical purposes compared to CNT alone. To test this, we treated RAW 264.7 murine macrophages (RAW cells) with CNT-attached PVDF and analyzed the production of nitric oxide (NO), a potent proinflammatory mediator, in these cells...
December 2017: Immune Network
https://www.readbyqxmd.com/read/29302252/serosal-cavities-contain-two-populations-of-innate-like-integrin-%C3%AE-4highcd4-t-cells-integrin-%C3%AE-4%C3%AE-1-%C3%AE-6%C3%AE-1-%C3%AE-4%C3%AE-7-and-%C3%AE-4%C3%AE-1-%C3%AE-6%C3%AE-1-%C3%AE-4%C3%AE-7-cells
#7
Jeong In Yang, Chanho Park, Inseong Kho, Sujin Lee, Kyung-Suk Suh, Tae Jin Kim
We previously reported peritoneal innate-like integrin α4 (CD49d)highCD4+ T cells that provided help for B-1a cells. Here we analyzed the expression of various integrin chains on the peritoneal and pleural integrin α4highCD4+ T cells and investigated the functional heterogeneity of the subpopulations based on the integrin expression. Pleural cavity contained a lower ratio of integrin α4highCD4+ T cells to integrin α4lowCD4+ T cells than peritoneal cavity, but the pleural integrin α4highCD4+ T cells have the same characteristics of the peritoneal integrin α4highCD4+ T cells...
December 2017: Immune Network
https://www.readbyqxmd.com/read/29302251/immunotherapy-for-non-small-cell-lung-cancer-current-status-and-future-obstacles
#8
REVIEW
Ju Hwan Cho
Lung cancer is one of the leading causes of death worldwide. There are 2 major subtypes of lung cancer, non-small-cell lung cancer (NSCLC) and small-cell lung cancer (SCLC). Studies show that NSCLC is the more prevalent type of lung cancer that accounts for approximately 80%-85% of cases. Although, various treatment methods, such as chemotherapy, surgery, and radiation therapy have been used to treat lung cancer patients, there is an emergent need to develop more effective approaches to deal with advanced stages of tumors...
December 2017: Immune Network
https://www.readbyqxmd.com/read/29302250/lineage-differentiation-program-of-invariant-natural-killer-t-cells
#9
REVIEW
Dong-Il Kwon, You Jeong Lee
Invariant natural killer T (iNKT) cells are innate T cells restricted by CD1d molecules. They are positively selected in the thymic cortex and migrate to the medullary area, in which they differentiate into 3 different lineages. Promyelocytic leukemia zinc finger (PLZF) modulates this process, and PLZFhigh, PLZFintermediate, and PLZFlow iNKT cells are designated as NKT2, NKT17, and NKT1 cells, respectively. Analogous to conventional helper CD4 T cells, each subset expresses distinct combinations of transcription factors and produces different cytokines...
December 2017: Immune Network
https://www.readbyqxmd.com/read/29093656/functional-defects-in-type-3-innate-lymphoid-cells-and-classical-monocytes-in-a-patient-with-hyper-ige-syndrome
#10
Yuna Chang, Sung-Yoon Kang, Jihyun Kim, Hye-Ryun Kang, Hye Young Kim
Hyper-IgE syndrome (HIES) is a very rare primary immune deficiency characterized by elevated serum IgE levels, recurrent bacterial infections, chronic dermatitis, and connective tissue abnormalities. Autosomal dominant (AD) HIES involves a mutation in signal transducer and activator of transcription 3 (STAT3) that leads to an impaired TH17 response. STAT3 signaling is also involved in the function of RORγt(+) type 3 innate lymphoid cells (ILC3s) and RORγt(+)TH17 cells. The aim of this study was to investigate the role of innate immune cells such as innate lymphoid cells (ILCs), granulocytes, and monocytes in a patient with HIES...
October 2017: Immune Network
https://www.readbyqxmd.com/read/29093655/plasmacytoid-dendritic-cells-contribute-to-the-protective-immunity-induced-by-intranasal-treatment-with-fc-fused-interleukin-7-against-lethal-influenza-virus-infection
#11
Moon Cheol Kang, Han Wook Park, Dong-Hoon Choi, Young Woo Choi, Yunji Park, Young Chul Sung, Seung-Woo Lee
Developing a novel vaccine that can be applied against multiple strains of influenza virus is of utmost importance to human health. Previously, we demonstrated that the intranasal introduction of Fc-fused IL-7 (IL-7-mFc), a long-acting cytokine fusion protein, confers long-lasting prophylaxis against multiple strains of influenza A virus (IAV) by inducing the development of lung-resident memory-like T cells, called TRM-like cells. Here, we further investigated the mechanisms of IL-7-mFc-mediated protective immunity to IAVs...
October 2017: Immune Network
https://www.readbyqxmd.com/read/29093654/distinct-effects-of-monophosphoryl-lipid-a-oligodeoxynucleotide-cpg-and-combination-adjuvants-on-modulating-innate-and-adaptive-immune-responses-to-influenza-vaccination
#12
Eun-Ju Ko, Young-Tae Lee, Youri Lee, Ki-Hye Kim, Sang-Moo Kang
Monophosphoryl lipid A (MPL) and oligodeoxynucleotide CpG are toll-like receptor (TLR) 4 and 9 agonist, respectively. Here, we investigated the effects of MPL, CpG, and combination adjuvants on stimulating in vitro dendritic cells (DCs), in vivo innate and adaptive immune responses, and protective efficacy of influenza vaccination. Combination of MPL and CpG was found to exhibit distinct effects on stimulating DCs in vitro to secrete IL-12p70 and tumor necrosis factor (TNF)-α and proliferate allogeneic CD8 T cells...
October 2017: Immune Network
https://www.readbyqxmd.com/read/29093653/comparison-of-the-commercial-quantiferon-cmv-and-overlapping-peptide-based-elispot-assays-for-predicting-cmv-infection-in-kidney-transplant-recipients
#13
Ji-Soo Kwon, Taeeun Kim, Sun-Mi Kim, Heungsup Sung, Sung Shin, Young Hoon Kim, Eui-Cheol Shin, Sung-Han Kim, Duck Jong Han
Cytomegalovirus (CMV) is one of the most important opportunistic infections in transplant recipients. Tests for CMV-specific T cell responses have been proposed to change the current risk stratification strategy using CMV assays. We evaluated the usefulness of pre-transplant CMV-specific T cell assays in kidney transplant (KT) candidates for predicting the development of CMV infection after transplantation comparing the results of the overlapping peptides (OLPs)-based enzyme-linked immunospot (ELISPOT) assay and the commercial QuantiFERON-CMV assay...
October 2017: Immune Network
https://www.readbyqxmd.com/read/29093652/semi-functional-quantitative-flow-cytometry-assay-for-lymphocytic-choriomeningitis-virus-titration
#14
Young Ho Ban, Sang-Jun Ha
Quantitative PCR and plaque assay are powerful virological techniques used to measure the load of defective or infectious virus in mouse and human. However, these methods display limitations such as cross contamination and long run-time. Here, we describe a novel technique termed as semi-functional quantitative flow cytometry (SFQF) for the accurate estimation of the quantity of infectious lymphocytic choriomeningitis virus (LCMV). LCMV titration method using flow cytometry was previously developed but has technical shortcomings, owing to the less optimized parameters such as cell overgrowth, plate scale, and detection threshold...
October 2017: Immune Network
https://www.readbyqxmd.com/read/29093651/current-understanding-in-neutrophil-differentiation-and-heterogeneity
#15
REVIEW
Chang-Won Hong
Neutrophils are professional phagocytes that conduct effectors functions in the innate immune systems. They are differentiated in the bone marrow (BM) and terminally differentiated neutrophils are then released into systemic circulation. Neutrophils migrate into inflammatory foci through extravasation, reverse transmigration, and chemotaxis. As neutrophils arrive at a target site, they actively participate in eliminating pathogens. They phagocytose bacteria, and eliminate them through the generation of reactive oxygen species (ROS), release of protease-enriched granules, and formation of neutrophil extracellular traps (NETs)...
October 2017: Immune Network
https://www.readbyqxmd.com/read/29093650/understanding-the-pathogenesis-of-zika-virus-infection-using-animal-models
#16
REVIEW
Keeton K Krause, Francine Azouz, Ok Sarah Shin, Mukesh Kumar
Zika virus (ZIKV) is a member of Flaviviridae family that has emerged as a pathogen of significant public health importance. The rapid expansion of ZIKV in the South and Central America has recently gained medical attention emphasizing the capacity of ZIKV to spread to non-endemic regions. ZIKV infection during pregnancy has been demonstrated to cause microcephaly and other fetal developmental abnormalities. An increased incidence of Guillain-Barre syndrome, an immune mediated neuropathy of the peripheral nervous system, has also been reported in ZIKV-infected patients in French Polynesia and Brazil...
October 2017: Immune Network
https://www.readbyqxmd.com/read/29093649/il-17a-producing-foxp3-regulatory-t-cells-and-human-diseases
#17
REVIEW
Min Kyung Jung, Jeong-Eun Kwak, Eui-Cheol Shin
CD4+Foxp3+ regulatory T (Treg) cells play major roles in immune homeostasis. While CD4+Foxp3+ Treg cells act to suppress other immune effector cells, there is growing evidence that they also produce pro-inflammatory cytokines, such as IL-17A, in inflammatory conditions. The pro-inflammatory cytokine milieu, toll-like receptor (TLR) signaling, and specific transcription factors are important for the production of IL-17A by CD4+Foxp3+ Treg cells. In particular, IL-17A-producing CD4+Foxp3+ Treg cells express RORγt, the T helper (Th) 17-specific transcription factor, in addition to Foxp3...
October 2017: Immune Network
https://www.readbyqxmd.com/read/29093648/immune-network-selected-for-science-citation-index-expanded
#18
EDITORIAL
Chong-Kil Lee
No abstract text is available yet for this article.
October 2017: Immune Network
https://www.readbyqxmd.com/read/28860956/diagnosis-of-lymphoid-malignancy-by-pcr-for-analysis-of-antigen-receptor-rearrangement-after-blood-transfusion-in-a-dog-with-acute-lymphocytic-leukemia
#19
Suhee Kim, Hyunwoo Kim, Soo-Hyeon Lee, Ilhan Cho, Seongwoo Kang, Junwoo Bae, Woosun Kim, Soomin Ahn, Jihye Choi, Sang-Ki Kim, Yoonjung Do, Jae Gyu Yoo, Jinho Park, DoHyeon Yu
Acute lymphocytic leukemia (ALL) is uncommon lymphoid malignancy in dogs, and its diagnosis is challenging. A 14-year-old spayed female mixed breed dog was transferred to a veterinary medical teaching hospital for an immediate blood transfusion. The dog showed lethargy, pale mucous membranes, and a weak femoral pulse. Complete blood count revealed non-regenerative anemia and severe leukopenia with thrombocytopenia. ALL was tentatively diagnosed based on the predominance of immature lymphoblasts on blood film examination...
August 2017: Immune Network
https://www.readbyqxmd.com/read/28860955/localization-of-serum-amyloid-a3-in-the-mouse-ovary
#20
Hyeongjwa Choi, Rosa Mistica C Ignacio, Eun-Sook Lee, Katherine F Roby, Paul F Terranova, Deok-Soo Son
Tumor necrosis factor-α (TNF-α) induces serum amyloid A (SAA) 3 among acute-phase proteins in mouse granulosa cells by activating NF-κB signaling via p55 TNF-α receptor type 1. However, the localization of SAA3 within the ovary is unknown. Here we investigated ovarian localization of SAA3 in a mouse ovulation model and in response to IL-1β, a proinflammatory mediator. For the ovulation model, equine chorionic gonadotropin (eCG; 2.5 IU) was administered to mice subcutaneously (sc) to stimulate follicular development on day 25 of age and then 50 h after eCG, human chorionic gonadotropin (hCG; 2...
August 2017: Immune Network
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