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Immune Network

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https://www.readbyqxmd.com/read/29093656/functional-defects-in-type-3-innate-lymphoid-cells-and-classical-monocytes-in-a-patient-with-hyper-ige-syndrome
#1
Yuna Chang, Sung-Yoon Kang, Jihyun Kim, Hye-Ryun Kang, Hye Young Kim
Hyper-IgE syndrome (HIES) is a very rare primary immune deficiency characterized by elevated serum IgE levels, recurrent bacterial infections, chronic dermatitis, and connective tissue abnormalities. Autosomal dominant (AD) HIES involves a mutation in signal transducer and activator of transcription 3 (STAT3) that leads to an impaired TH17 response. STAT3 signaling is also involved in the function of RORγt(+) type 3 innate lymphoid cells (ILC3s) and RORγt(+)TH17 cells. The aim of this study was to investigate the role of innate immune cells such as innate lymphoid cells (ILCs), granulocytes, and monocytes in a patient with HIES...
October 2017: Immune Network
https://www.readbyqxmd.com/read/29093655/plasmacytoid-dendritic-cells-contribute-to-the-protective-immunity-induced-by-intranasal-treatment-with-fc-fused-interleukin-7-against-lethal-influenza-virus-infection
#2
Moon Cheol Kang, Han Wook Park, Dong-Hoon Choi, Young Woo Choi, Yunji Park, Young Chul Sung, Seung-Woo Lee
Developing a novel vaccine that can be applied against multiple strains of influenza virus is of utmost importance to human health. Previously, we demonstrated that the intranasal introduction of Fc-fused IL-7 (IL-7-mFc), a long-acting cytokine fusion protein, confers long-lasting prophylaxis against multiple strains of influenza A virus (IAV) by inducing the development of lung-resident memory-like T cells, called TRM-like cells. Here, we further investigated the mechanisms of IL-7-mFc-mediated protective immunity to IAVs...
October 2017: Immune Network
https://www.readbyqxmd.com/read/29093654/distinct-effects-of-monophosphoryl-lipid-a-oligodeoxynucleotide-cpg-and-combination-adjuvants-on-modulating-innate-and-adaptive-immune-responses-to-influenza-vaccination
#3
Eun-Ju Ko, Young-Tae Lee, Youri Lee, Ki-Hye Kim, Sang-Moo Kang
Monophosphoryl lipid A (MPL) and oligodeoxynucleotide CpG are toll-like receptor (TLR) 4 and 9 agonist, respectively. Here, we investigated the effects of MPL, CpG, and combination adjuvants on stimulating in vitro dendritic cells (DCs), in vivo innate and adaptive immune responses, and protective efficacy of influenza vaccination. Combination of MPL and CpG was found to exhibit distinct effects on stimulating DCs in vitro to secrete IL-12p70 and tumor necrosis factor (TNF)-α and proliferate allogeneic CD8 T cells...
October 2017: Immune Network
https://www.readbyqxmd.com/read/29093653/comparison-of-the-commercial-quantiferon-cmv-and-overlapping-peptide-based-elispot-assays-for-predicting-cmv-infection-in-kidney-transplant-recipients
#4
Ji-Soo Kwon, Taeeun Kim, Sun-Mi Kim, Heungsup Sung, Sung Shin, Young Hoon Kim, Eui-Cheol Shin, Sung-Han Kim, Duck Jong Han
Cytomegalovirus (CMV) is one of the most important opportunistic infections in transplant recipients. Tests for CMV-specific T cell responses have been proposed to change the current risk stratification strategy using CMV assays. We evaluated the usefulness of pre-transplant CMV-specific T cell assays in kidney transplant (KT) candidates for predicting the development of CMV infection after transplantation comparing the results of the overlapping peptides (OLPs)-based enzyme-linked immunospot (ELISPOT) assay and the commercial QuantiFERON-CMV assay...
October 2017: Immune Network
https://www.readbyqxmd.com/read/29093652/semi-functional-quantitative-flow-cytometry-assay-for-lymphocytic-choriomeningitis-virus-titration
#5
Young Ho Ban, Sang-Jun Ha
Quantitative PCR and plaque assay are powerful virological techniques used to measure the load of defective or infectious virus in mouse and human. However, these methods display limitations such as cross contamination and long run-time. Here, we describe a novel technique termed as semi-functional quantitative flow cytometry (SFQF) for the accurate estimation of the quantity of infectious lymphocytic choriomeningitis virus (LCMV). LCMV titration method using flow cytometry was previously developed but has technical shortcomings, owing to the less optimized parameters such as cell overgrowth, plate scale, and detection threshold...
October 2017: Immune Network
https://www.readbyqxmd.com/read/29093651/current-understanding-in-neutrophil-differentiation-and-heterogeneity
#6
REVIEW
Chang-Won Hong
Neutrophils are professional phagocytes that conduct effectors functions in the innate immune systems. They are differentiated in the bone marrow (BM) and terminally differentiated neutrophils are then released into systemic circulation. Neutrophils migrate into inflammatory foci through extravasation, reverse transmigration, and chemotaxis. As neutrophils arrive at a target site, they actively participate in eliminating pathogens. They phagocytose bacteria, and eliminate them through the generation of reactive oxygen species (ROS), release of protease-enriched granules, and formation of neutrophil extracellular traps (NETs)...
October 2017: Immune Network
https://www.readbyqxmd.com/read/29093650/understanding-the-pathogenesis-of-zika-virus-infection-using-animal-models
#7
REVIEW
Keeton K Krause, Francine Azouz, Ok Sarah Shin, Mukesh Kumar
Zika virus (ZIKV) is a member of Flaviviridae family that has emerged as a pathogen of significant public health importance. The rapid expansion of ZIKV in the South and Central America has recently gained medical attention emphasizing the capacity of ZIKV to spread to non-endemic regions. ZIKV infection during pregnancy has been demonstrated to cause microcephaly and other fetal developmental abnormalities. An increased incidence of Guillain-Barre syndrome, an immune mediated neuropathy of the peripheral nervous system, has also been reported in ZIKV-infected patients in French Polynesia and Brazil...
October 2017: Immune Network
https://www.readbyqxmd.com/read/29093649/il-17a-producing-foxp3-regulatory-t-cells-and-human-diseases
#8
REVIEW
Min Kyung Jung, Jeong-Eun Kwak, Eui-Cheol Shin
CD4(+)Foxp3(+) regulatory T (Treg) cells play major roles in immune homeostasis. While CD4(+)Foxp3(+) Treg cells act to suppress other immune effector cells, there is growing evidence that they also produce pro-inflammatory cytokines, such as IL-17A, in inflammatory conditions. The pro-inflammatory cytokine milieu, toll-like receptor (TLR) signaling, and specific transcription factors are important for the production of IL-17A by CD4(+)Foxp3(+) Treg cells. In particular, IL-17A-producing CD4(+)Foxp3(+) Treg cells express RORγt, the T helper (Th) 17-specific transcription factor, in addition to Foxp3...
October 2017: Immune Network
https://www.readbyqxmd.com/read/29093648/immune-network-selected-for-science-citation-index-expanded
#9
EDITORIAL
Chong-Kil Lee
No abstract text is available yet for this article.
October 2017: Immune Network
https://www.readbyqxmd.com/read/28860956/diagnosis-of-lymphoid-malignancy-by-pcr-for-analysis-of-antigen-receptor-rearrangement-after-blood-transfusion-in-a-dog-with-acute-lymphocytic-leukemia
#10
Suhee Kim, Hyunwoo Kim, Soo-Hyeon Lee, Ilhan Cho, Seongwoo Kang, Junwoo Bae, Woosun Kim, Soomin Ahn, Jihye Choi, Sang-Ki Kim, Yoonjung Do, Jae Gyu Yoo, Jinho Park, DoHyeon Yu
Acute lymphocytic leukemia (ALL) is uncommon lymphoid malignancy in dogs, and its diagnosis is challenging. A 14-year-old spayed female mixed breed dog was transferred to a veterinary medical teaching hospital for an immediate blood transfusion. The dog showed lethargy, pale mucous membranes, and a weak femoral pulse. Complete blood count revealed non-regenerative anemia and severe leukopenia with thrombocytopenia. ALL was tentatively diagnosed based on the predominance of immature lymphoblasts on blood film examination...
August 2017: Immune Network
https://www.readbyqxmd.com/read/28860955/localization-of-serum-amyloid-a3-in-the-mouse-ovary
#11
Hyeongjwa Choi, Rosa Mistica C Ignacio, Eun-Sook Lee, Katherine F Roby, Paul F Terranova, Deok-Soo Son
Tumor necrosis factor-α (TNF-α) induces serum amyloid A (SAA) 3 among acute-phase proteins in mouse granulosa cells by activating NF-κB signaling via p55 TNF-α receptor type 1. However, the localization of SAA3 within the ovary is unknown. Here we investigated ovarian localization of SAA3 in a mouse ovulation model and in response to IL-1β, a proinflammatory mediator. For the ovulation model, equine chorionic gonadotropin (eCG; 2.5 IU) was administered to mice subcutaneously (sc) to stimulate follicular development on day 25 of age and then 50 h after eCG, human chorionic gonadotropin (hCG; 2...
August 2017: Immune Network
https://www.readbyqxmd.com/read/28860954/distinct-clinical-outcomes-between-paramedullary-and-extramedullary-lesions-in-newly-diagnosed-multiple-myeloma
#12
Khishigjargal Batsukh, Sung-Eun Lee, Gi June Min, Sung Soo Park, Young-Woo Jeon, Jae-Ho Yoon, Byung-Sik Cho, Ki-Seong Eom, Yoo-Jin Kim, Hee-Je Kim, Seok Lee, Seok-Goo Cho, Dong-Wook Kim, Jong Wook Lee, Woo-Sung Min, Chang-Ki Min
This retrospective study aimed to compare the clinical features of paramedullary lesions (PLs) and extramedullary lesions (ELs) of plasmacytomas at diagnosis, using positron emission tomography integrated with computed tomography, using glucose labeled with the positron-emitting radionuclide (18)F ((18)F-FDG-PET/CT) in newly diagnosed multiple myeloma (NDMM), and to address their prognostic impact. Sixty-four patients with NDMM presenting ELs (n=22) and/or PLs (n=42) were included. Patients with ELs at initial presentation had unfavorable laboratory parameters of calcium and lactate dehydrogenase, a higher percentage of bone marrow plasma cells, and showed a trend toward advanced international staging system (ISS), compared to patients with PLs...
August 2017: Immune Network
https://www.readbyqxmd.com/read/28860953/comparative-analyses-of-signature-genes-in-acute-rejection-and-operational-tolerance
#13
Jeong-Woo Choi, Yong-Hee Kim, Ji Won Oh
Using biomarkers as prediction tools or therapeutic targets can be a valuable strategy in transplantation. Recent studies identified biomarkers of acute rejection (AR) and operational tolerance (TOL) through the application of meta-analysis. In this study, we comparatively analyzed the signature genes in acute rejection and operational tolerance seen in human allogeneic transplantations using massive bioinformatical meta-analysis. To identify the signature genes in opposite immunological conditions, AR and TOL, we first collected the 1,252 gene expression data specifically intended for those circumstances...
August 2017: Immune Network
https://www.readbyqxmd.com/read/28860952/yersinia-enterocolitica-exploits-signal-crosstalk-between-complement-5a-receptor-and-toll-like-receptor-1-2-and-4-to-avoid-the-bacterial-clearance-in-m-cells
#14
Sae-Hae Kim, Yong-Suk Jang
In the intestinal mucosal surface, microfold cells (M cells) are the representative gateway for the uptake of luminal antigens. At the same time, M cells are the primary infection site for pathogens invading mucosal surface for their infection. Although it is well recognized that many mucosal pathogens exploit the M cells for their infection, the mechanism to infect M cells utilized by pathogens is not clearly understood yet. In this study, we found that M cells expressing complement 5a (C5a) receptor (C5aR) also express Toll-like receptor (TLR) 1/2 and TLR4...
August 2017: Immune Network
https://www.readbyqxmd.com/read/28860951/cytokine-signaling-in-tumor-progression
#15
REVIEW
Myungmi Lee, Inmoo Rhee
Cytokines are molecules that play critical roles in the regulation of a wide range of normal functions leading to cellular proliferation, differentiation and survival, as well as in specialized cellular functions enabling host resistance to pathogens. Cytokines released in response to infection, inflammation or immunity can also inhibit cancer development and progression. The predominant intracellular signaling pathway triggered by cytokines is the JAK-signal transducer and activator of transcription (STAT) pathway...
August 2017: Immune Network
https://www.readbyqxmd.com/read/28860950/t-cell-s-sense-of-self-a-role-of-self-recognition-in-shaping-functional-competence-of-na%C3%A3-ve-t-cells
#16
REVIEW
Hee-Ok Kim, Jae-Ho Cho
Post-thymic naïve T cells constitute a key cellular arm of adaptive immunity, with a well-known characteristic of the specificity and robustness of responses to cognate foreign antigens which is presented as a form of antigen-derived peptides bound to major histocompatibility complex (MHC) molecules by antigen-presenting cells (APCs). In a steady state, however, these cells are resting, quiescent in their activity, but must keep full ranges of functional integrity to mount rapid and robust immunity to cope with various infectious pathogens at any time and space...
August 2017: Immune Network
https://www.readbyqxmd.com/read/28680381/exacerbation-of-japanese-encephalitis-by-cd11c-hi-dendritic-cell-ablation-is-associated-with-an-imbalance-in-regulatory-foxp3-and-il-17-cd4-th17-cells-and-in-ly-6c-hi-and-ly-6c-lo-monocytes
#17
Jin Young Choi, Jin Hyoung Kim, Ajit Mahadev Patil, Seong Bum Kim, Erdenebelig Uyangaa, Ferdaus Mohd Altaf Hossain, Seong Kug Eo
Japanese encephalitis (JE) is neuroinflammation characterized by uncontrolled infiltration of peripheral leukocytes into the central nervous system (CNS). We previously demonstrated exacerbation of JE following CD11c(hi) dendritic cell (DC) ablation in CD11c-DTR transgenic mice. Moreover, CD11c(hi) DC ablation led to abnormal differentiation of CD11b(+)Ly-6C(hi) monocytes and enhanced permeability of the blood-brain barrier (BBB), resulting in promoting the progression of JE. Here, we examined changes in lymphoid and myeloid-derived leukocyte subpopulations associated with pro- and anti-inflammation during JE progression...
June 2017: Immune Network
https://www.readbyqxmd.com/read/28680380/moderate-exercise-enhances-the-production-of-interferon-%C3%AE-and-interleukin-12-in-peripheral-blood-mononuclear-cells
#18
Alireza Zamani, Iraj Salehi, Mahdi Alahgholi-Hajibehzad
The purpose of this study was to explore the effect of two months moderate exercise on levels of IFN-γ, IL-12, IL-6 and IL-4 in serum and supernatants of in vitro mitogen-activated (PHA for 48 h) whole blood (WB) and peripheral blood mononuclear cells (PBMCs). Sixteen healthy males participated in running program (30 min/day, 5 days/week). Blood samples were collected in three stages; 24 h before to start exercise, 48 h and two months after the last session of the exercise. The samples were analyzed for the cytokines by ELISA...
June 2017: Immune Network
https://www.readbyqxmd.com/read/28680379/diclofenac-inhibits-27-hydroxycholesterol-induced-differentiation-of-monocytic-cells-into-mature-dendritic-cells
#19
Yonghae Son, Bo-Young Kim, Young Chul Park, Koanhoi Kim
We investigated whether diclofenac could influence the development of antigen-presenting cells in an oxygenated cholesterol-rich environment by determining its effects on the 27-hydroxycholesterol (27OHChol)-induced differentiation of monocytic cells into mature dendritic cells (mDCs). Treatment of human THP-1 monocytic cells with diclofenac antagonized the effects of 27OHChol by attenuating dendrite formation and cell attachment and promoting endocytic function. Diclofenac inhibited the transcription and surface expression of the mDC markers of CD80, CD83, and CD88, and reduced the 27OHChol-induced elevation of surface levels of MHC class I and II molecules to the basal levels in a dose-dependent manner...
June 2017: Immune Network
https://www.readbyqxmd.com/read/28680378/effects-of-cellular-11%C3%AE-hydroxysteroid-dehydrogenase-1-on-lps-induced-inflammatory-responses-in-synovial-cell-line-sw982
#20
Young Sik Cho, Ki Nam Kim, Jung Hyun Shim
11β-hydroxysteroid dehydrogenase 1 (11β-HSD1) catalyzes the conversion of inactive cortisone into active cortisol, which has pleiotropic roles in various biological conditions, such as immunological and metabolic homeostasis. Cortisol is mainly produced in the adrenal gland, but can be locally regenerated in the liver, fat, and muscle. Its diverse actions are primarily mediated by binding to the glucocorticoid receptor. SW982, a human synovial cell line, expresses 11β-HSD type 1, but not type 2, that catalyzes the conversion of cortisone to cortisol...
June 2017: Immune Network
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