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Journal of Maternal-fetal & Neonatal Medicine

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https://www.readbyqxmd.com/read/28081646/comparison-of-rapid-mmp-8-and-interleukin-6-point-of-care-tests-to-identify-intra-amniotic-inflammation-infection-and-impending-preterm-delivery-in-patients-with-preterm-labor-and-intact-membranes
#1
Piya Chaemsaithong, Roberto Romero, Nikolina Docheva, Noppadol Chaiyasit, Gaurav Bhatti, Percy Pacora, Sonia S Hassan, Lami Yeo, Offer Erez
OBJECTIVE: Among patients presenting with preterm labor and intact membranes, those with intra-amniotic inflammation have worse obstetrical and neonatal outcomes. The diagnosis of intra-amniotic inflammation can be easily made by detecting an elevated concentration of the cytokine interleukin (IL)-6 or the enzyme neutrophil collagenase, also known as matrix metalloproteinase (MMP)-8. The diagnostic performances of MMP-8 and IL-6 enzyme-linked immunosorbent assay (ELISA) tests are similar...
January 12, 2017: Journal of Maternal-fetal & Neonatal Medicine
https://www.readbyqxmd.com/read/28081642/first-trimester-placental-vascular-development-in-multiparous-women-differs-from-that-in-nulliparous-women
#2
Gea Ballering, Janneke Leijnse, Niels Eijkelkamp, Louis Peeters, Roel de Heus
OBJECTIVE: Multiparas differ from nulliparas by delivering larger babies with larger placentas and by having a lower risk of developing placental syndromes. We postulate that these differences result from a different initial course of placental vascular development. STUDY DESIGN: We measured placental flow index (FI), vascularization index (VI) and placental volume by 3D power Doppler and obtained blood samples at 8, 10 and 12 weeks pregnancy in 34 healthy nulliparous and 16 multiparous women with an uneventful pregnancy...
January 12, 2017: Journal of Maternal-fetal & Neonatal Medicine
https://www.readbyqxmd.com/read/28081639/differential-expression-of-cord-blood-neurotrophins-in-gestational-diabetes-the-impact-of-fetal-growth-abnormalities
#3
Despina D Briana, Maria Papastavrou, Maria Boutsikou, Antonios Marmarinos, Dimitrios Gourgiotis, Ariadne Malamitsi-Puchner
OBJECTIVE: Gestational diabetes mellitus (GDM) may induce fetal macrosomia or growth restriction and is associated with later offspring neurodevelopmental disorders. We aimed to determine whether neurotrophins brain-derived neurotrophic factor-(BDNF), nerve growth factor-(NGF) and neurotrophin-4-(NT-4) are differentially expressed in cord blood samples at birth in large-for-gestational-age-(LGA), intrauterine-growth-restricted-(IUGR) and appropriate-for-gestational-age-(AGA) offspring of diabetic mothers, as compared to AGA controls from non-diabetic mothers...
January 12, 2017: Journal of Maternal-fetal & Neonatal Medicine
https://www.readbyqxmd.com/read/28081638/echocardiography-may-cause-significant-pain-response-in-preterm-infants
#4
Selma Aktas, Dilek Ulubas, Mehmet Gumustas, Ibrahim Murat Hirfanoglu, Canan Turkyilmaz, Ebru Ergenekon, Esin Koc, Yildiz Atalay, Nihal Demirel, Ahmet Yagmur Bas, Eray Esra Onal
OBJECTIVE: The objective of this study is to evaluate if echocardiographic examination causes any pain response in term and preterm infants. METHODS: Term and preterm neonates who admitted to Neonatal Intensive Care Unit at Gazi University Hospital and Etlik Zubeyde Hanim Training and Research Hospital and were performed echocardiography for any reason were included into the study. Neonates were evaluated before, during and 10 minutes after the examination. Vital signs (heart rate, respiratory rate, blood pressure, transcutaneous oxygen saturation) were recorded...
January 12, 2017: Journal of Maternal-fetal & Neonatal Medicine
https://www.readbyqxmd.com/read/27936998/a-comparison-of-maternal-and-perinatal-outcome-between-in-vitro-fertilization-and-spontaneous-dichorionic-diamniotic-twin-pregnancies
#5
Giulia Barda, Ohad Gluck, Yossi Mizrachi, Jacob Bar
OBJECTIVE: To compare the maternal and neonatal outcome of dichorionic diamniotic in vitro fertilization (IVF) twin and spontaneous twin pregnancies. MATERIAL AND METHODS: Maternal and fetal data of all consecutive dichorionic-diamniotic twin pregnancies delivered in our institution between January 2009 and May 2015 were abstracted from medical records and pregnancy outcome of IVF twin was compared to spontaneous twin. RESULTS: Overall 708 twin pregnancies (449 IVF and 259 spontaneous) were included...
January 12, 2017: Journal of Maternal-fetal & Neonatal Medicine
https://www.readbyqxmd.com/read/28076992/the-issue-of-delivery-room-infections-in-the-italian-law-a-brief-comparative-study-with-english-and-french-jurisprudence
#6
Simona Zaami, Gianluca Montanari Vergallo, Simona Napoletano, Fabrizio Signore, Enrico Marinelli
Delivery room infections are frequent, and many of them could be avoided through higher standards of care. The authors examine this issue by comparing it to English and French reality. Unlike England, in Italy and France the relationship established between health facility, physician and patient is outlined in a contract. In England, the judges' decisions converge towards a better and higher protection of the patient - the actor - and facilitate the probative task. In case of infections, including those occurring in the delivery room, three issues are evaluated: the hospital's negligent conduct, damages if any and causal nexus...
January 11, 2017: Journal of Maternal-fetal & Neonatal Medicine
https://www.readbyqxmd.com/read/28076991/type-2-diabetes-mellitus-does-prenatal-care-affect-outcomes-suggested-running-head-treatment-of-t2dm-and-perinatal-outcomes
#7
Allison J Allen, Jonathan M Snowden, Bernard Lau, Yvonne Cheng, Aaron B Caughey
OBJECTIVE: To determine if prenatal care affects adverse perinatal outcomes in pregnant women with Type-2 Diabetes Mellitus. STUDY DESIGN: This was a retrospective cohort study of pregnant women with pregestational diabetes mellitus pregnancies in the state of California between 1997 and 2006, using vital statistics data linked to birth certificates. Women were stratified by time of presentation to care and we compared those who presented in the first trimester, third trimester, and those who had no prenatal care prior to delivery...
January 11, 2017: Journal of Maternal-fetal & Neonatal Medicine
https://www.readbyqxmd.com/read/28076990/outcomes-in-the-absence-of-the-ductus-venosus-diagnosed-in-the-first-trimester
#8
Hiroko Takita, Junichi Hasegawa, Tatsuya Arakaki, Shoko Hamada, Mayumi Tokunaka, Masamitsu Nakamura, Ryu Matsuoka, Akihiko Sekizawa
PURPOSE: To clarify the outcomes of the absence of the ductus venosus diagnosed in fetuses suspected to have a structural abnormality during a morphological assessment in the first trimester. METHODS: Infants in whom ultrasound fetal morphological assessments were attempted in the first trimester (11 to 13-6 weeks of gestation) and who were subsequently delivered between 2013 and 2015 at Showa University Hospital were enrolled. In cases in which the absence of the ductus venosus was diagnosed in the first trimester, the prognosis was assessed...
January 11, 2017: Journal of Maternal-fetal & Neonatal Medicine
https://www.readbyqxmd.com/read/28076981/prenatal-drainage-of-fetal-urinoma-with-polyhydramnios-a-case-report-and-literature-review
#9
H J Zhang, H X Yang, Y Sun, L X Fan, X X Zhang
The appearance of fetal urinoma is rare in prenatal care, especially when associated with polyhydramnions. Many previous reports have concluded that the visualization of a prenatal urinoma is probably a sign of undelying renal dysplasia or poor function. Thus, the management of the reported cases, conservative treatment or uniroma drainage, has not been unified. In this paper, we present two cases of prenatally detected urinoma with prenatal drainage to improve the prognosis.
January 11, 2017: Journal of Maternal-fetal & Neonatal Medicine
https://www.readbyqxmd.com/read/28068860/does-adjunctive-use-of-progesterone-in-women-with-cerclage-improve-prevention-of-preterm-birth
#10
Rachel G Sinkey, Mercedes R Garcia, Anthony O Odibo
OBJECTIVE: To evaluate outcomes among pregnancies with cerclage as compared to cerclage and adjunctive progesterone. METHODS: A retrospective cohort study was performed from 10/1/11 - 6/30/15 including women with a singleton gestation with vaginal cerclage. Exclusion criteria included multiple gestations, simultaneous 17-alpha hydroxyprogesterone caproate (17-OHPC) and vaginal progesterone (vag-p) use, and patients lost to follow-up. Primary outcome was prevention of preterm birth less than 35 (PTB < 35) weeks gestational age (GA)...
January 9, 2017: Journal of Maternal-fetal & Neonatal Medicine
https://www.readbyqxmd.com/read/28068852/maternal-outcomes-following-the-initiation-of-an-institutional-delayed-cord-clamping-protocol-an-observational-case-control-study
#11
Kelly Kuo, Priyanka Gohale, David N Hackney, Chayatat Ruangkit, Monika Bhola, Melissa I March
OBJECTIVE: To evaluate maternal outcomes before and after implementation of an institutional delayed cord clamping (DCC) protocol. STUDY DESIGN: We performed a secondary analysis of a retrospective cohort study of deliveries occurring at <34 weeks at a tertiary care center in 2013-2014. 139 women who underwent early cord clamping were compared to 130 women delivered after DCC protocol implementation. Maternal estimated blood loss (EBL) was the primary outcome of interest...
January 9, 2017: Journal of Maternal-fetal & Neonatal Medicine
https://www.readbyqxmd.com/read/28068849/maternal-serum-calponin-1-level-as-a-biomarker-for-the-short-term-prediction-of-preterm-birth-in-women-with-threatened-preterm-labor
#12
Orkun Cetin, Erbil Karaman, Baris Boza, Numan Cim, Hanım Guler Sahin
PURPOSE: To assess the utility of maternal serum calponin 1 level in the prediction of delivery within 7 days among pregnancies complicated with threatened preterm labor. MATERIALS AND METHODS: Eligible women who presented at 24-34 weeks of gestation with threatened preterm labor underwent sampling for serum calponin 1 level and cervical length measurement. They were followed-up until delivery prospectively and the perinatal outcomes of the patients were recorded...
January 9, 2017: Journal of Maternal-fetal & Neonatal Medicine
https://www.readbyqxmd.com/read/28068846/impact-of-tamsulosin-and-nifedipine-on-contractility-of-pregnant-rat-ureters-in-vitro
#13
Lisette Haddad, Stéphanie Corriveau, Eric Rousseau, Simon Blouin, Jean-Charles Pasquier, Yves Ponsot, Marie-Ève Roy-Lacroix
OBJECTIVES: To evaluate the in vitro effect of tamsulosin and nifedipine on the contractility of pregnant rat ureters and to perform quantitative analysis of the pharmacological effects. Medical expulsive therapy (MET) is commonly used to treat urolithiasis. However, this treatment is seldom used in pregnant women since no studies support this practice. METHODS: This was an in vitro study on animal tissue derived from pregnant Sprague-Dawley rats. A total of 124 ureteral segments were mounted in an organ bath system and contractile response to methacholine (MCh) was assessed...
January 9, 2017: Journal of Maternal-fetal & Neonatal Medicine
https://www.readbyqxmd.com/read/28064549/mother-to-child-transmission-of-human-immunodeficiency-virus-hiv-among-hiv-infected-pregnant-women-on-highly-active-anti-retroviral-therapy-with-premature-rupture-of-membranes-at-term
#14
George Uchenna Eleje, Emeka Stephen Edokwe, Joseph Ifeanyichukwu Ikechebelu, Chinyere Ukamaka Onubogu, Ebele Francesca Ugochukwu, Princeston Chukwuemeka Okam, Adaobi Maryann Ibekwe
PURPOSE: To determine mother-to-child transmission (MTCT) rate and associated risk factors of human immune-deficiency virus (HIV) among HIV-infected pregnant women with term premature rupture of membranes (PROM) in comparison with those without PROM at term. MATERIALS AND METHODS: All optimally managed HIV-positive pregnant women of Nnamdi Azikiwe University Teaching Hospital, on highly active anti-retroviral therapy (HAART) who had PROM at term were enrolled. Maternal HIV-1 viral load was not assessed...
January 8, 2017: Journal of Maternal-fetal & Neonatal Medicine
https://www.readbyqxmd.com/read/28064548/amniotic-fluid-sludge-prevalence-and-clinical-significans-of-it-in-asymptomatic-patients-at-high-risk-for-spontaneous-preterm-delivery
#15
Ilknur Adanir, Ozgur Ozyuncu, Ayse Filiz Gokmen Karasu, Lutfu S Onderoglu
INTRODUCTION: The aim of our study is to determine prevalence and clinical significance of the presence of amniotic fluid 'sludge' among asymptomatic patients at high-risk for spontaneous preterm delivery, prospectively. MATERIAL AND METHODS: In our study, 99 patients at high risk for spontaneous preterm delivery were evaluated for the presence of amniotic fluid sludge with transvaginal ultrasonography at 20-22., 26-28. and 32-34. gestational weeks, prospectively; between August 2009 and October 2010 in Hacettepe University Hospital...
January 8, 2017: Journal of Maternal-fetal & Neonatal Medicine
https://www.readbyqxmd.com/read/28056581/is-the-robson-s-classification-system-burdened-by-obstetric-pathologies-and-maternal-characteristics-and-assistential-levels-in-comparing-hospitals-cesarean-rates-a-regional-analysis-of-class-1-and-3
#16
Sandro Gerli, Alessandro Favilli, David Franchini, Marcello De Giorgi, Paola Casucci, Fabio Parazzini
OBJECTIVE: to assess if maternal risk profile and Hospital assistential levels were able to influence the inter-Hospitals comparison in the class 1 and 3 of the "The Ten Group Classification System" (TGCS). METHODS: a population-based analysis using data from Isititutional data-base of an Italian Region was carried out. The 11 maternity wards were divided into two categories: second-level hospitals (SLH), and first-level hospitals (FLH). The recorded deliveries were classified according to the TGCS...
January 6, 2017: Journal of Maternal-fetal & Neonatal Medicine
https://www.readbyqxmd.com/read/28056569/maternal-side-effects-fetal-neuroprotection-according-to-body-mass-index-after-magnesium-sulfate-in-a-multicenter-randomized-controlled-trial
#17
Gustavo Vilchez, Jing Dai, Moraima Lagos, Robert J Sokol
OBJECTIVE: Evidence supports the need of dose-adjustment of several drugs according to body mass index (BMI) to prevent toxicity in the underweight, and ensure efficacy in obese women. However, for MgSO4 neuroprotection, the effect of BMI on maternal toxicity and fetal neuroprotection is understudied. We analyze the effect of BMI on maternal/infant outcomes after MgSO4. METHODS: Secondary analysis of a clinical trial that studied MgSO4 neuroprotection. Maternal side effects, magnesium cord levels, and offspring cerebral palsy/death were analyzed along BMI strata using ANOVA and chi-square test...
January 6, 2017: Journal of Maternal-fetal & Neonatal Medicine
https://www.readbyqxmd.com/read/28052714/efficacy-and-safety-of-rectal-ibuprofen-for-patent-ductus-arteriosus-closure-in-very-low-birth-weight-preterm-infants
#18
Nihat Demir, Erdal Peker, İbrahim Ece, Ragıp Balahoroğlu, Oğuz Tuncer
BACKGROUND: To compare rectal ibuprofen with oral ibuprofen for closure of hemodynamically significant patent ductus arteriosus (hsPDA) in very low birth weight (VLBW) preterm infants. STUDY DESIGN AND SUBJECTS: In a prospective, randomized study, 72 VLBW infants who had hsPDA received either rectal or oral ibuprofen. The plasma concentration of ibuprofen and renal functions were determined in both groups by high performance liquid chromatography (HPLC) method and cystatin-C (cys-C), respectively...
January 4, 2017: Journal of Maternal-fetal & Neonatal Medicine
https://www.readbyqxmd.com/read/28052712/the-effects-of-perinatal-steroid-therapy-on-growth-factor-levels-during-different-stages-of-the-developing-brain
#19
Burçin İşcan, Funda Tuzun, Serap Cilaker Micili, Kazim Tugyan, Nuray Duman, Hasan Ozkan, Abdullah Kumral
OBJECTIVE: Excess glucocorticoid exposure on the fetal brain during critical stages of development has considerable effects on the development of the central nervous system. This study thus aimed to evaluate the differential effects of glucocorticoid exposure on critical growth factor levels during different stages of brain maturation. METHODS: For this purpose, forty-two rat pups were divided into six groups based on the timing of betamethasone administration. Rats in the treatment groups were exposed to intraperitoneal betamethasone injections beginning at different time points (postnatal days 1, 2, and 3)...
January 4, 2017: Journal of Maternal-fetal & Neonatal Medicine
https://www.readbyqxmd.com/read/28052705/authors-response-to-a-letter-to-the-editor-re-choosing-between-bad-worse-and-worst-what-is-the-preferred-mode-of-delivery-for-failure-of-the-second-stage-of-labor
#20
I Hendler, M Kirshenbaum
No abstract text is available yet for this article.
January 4, 2017: Journal of Maternal-fetal & Neonatal Medicine
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