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Journal of Maternal-fetal & Neonatal Medicine

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https://www.readbyqxmd.com/read/28427289/biomarkers-for-diagnosis-of-neonatal-sepsis-a-literature-review
#1
Deepak Sharma, Nazanin Farahbakhsh, Sweta Shastri, Pradeep Sharma
Sepsis is an important cause of mortality and morbidity in neonatal populations. There has been constant search of an ideal sepsis biomarker that have high sensitivity, specificity, positive predictive value (PPV) and negative predictive value (NPV), so that both the diagnosis and exclusion of neonatal sepsis can be made at the earliest possible and appropriate antibiotics can be started to neonate. Ideal sepsis biomarker will help in guiding us when not to start antibiotics in case of suspect sepsis and total duration of antibiotics course in case of proven sepsis...
April 20, 2017: Journal of Maternal-fetal & Neonatal Medicine
https://www.readbyqxmd.com/read/28423971/intrauterine-infection-immune-system-and-premature-birth
#2
Fernanda Rodrigues Helmo, Eduardo Arthur Rodovalho Alves, Renata Alves de Andrade Moreira, Viviane Oliveira Severino, Laura Penna Rocha, Maria Luíza Gonçalves Dos Reis Monteiro, Marlene Antônia Dos Reis, Renata Margarida Etchebehere, Juliana Reis Machado, Rosana Rosa Miranda Corrêa
Preterm birth accounts for nearly one million deaths among children under five years of age, and although its etiopathogenesis is not fully elucidated, ascending intrauterine infection and fetal inflammatory response seem to be the main triggers. The intense inflammatory response mediated by IL-1β, TNF-α, PAF, IFN-γ and IL-6, PGE2 and MMP-1 and MMP-9 causes fetal membrane damage and rupture, increased uterine contractions and biochemical and structural changes in the cervix. Furthermore, preterm neonates have deficient innate and adaptive immune responses characterized by reduced levels of IgG, opsonization and phagocytosis, as well as increased activation of Th1 cells in relation to Th2 cells...
April 20, 2017: Journal of Maternal-fetal & Neonatal Medicine
https://www.readbyqxmd.com/read/28423964/corrigendum
#3
(no author information available yet)
No abstract text is available yet for this article.
April 20, 2017: Journal of Maternal-fetal & Neonatal Medicine
https://www.readbyqxmd.com/read/28372511/prenatal-diagnosis-of-fetal-adducted-thumbs
#4
Yinon Gilboa, Michal Berkenstadt, Sofia Leytes, Reuven Achiron, Sharon Perlman
PURPOSE: One of the greatest challenges with the finding of adducted thumbs in the prenatal setting is the determination of whether this finding is associated with an underlying genetic syndrome. The aim of the present study is to describe the characteristics and outcome of prenatal sonographic diagnosis of adducted thumbs. METHODS: A retrospective study was conducted over a period of 17 years in a tertiary referral center. All fetuses diagnosed prenatally with adducted thumbs comprised the study group...
April 20, 2017: Journal of Maternal-fetal & Neonatal Medicine
https://www.readbyqxmd.com/read/28372510/delayed-cord-clamping-and-inotrope-use-in-preterm-infants
#5
Zachary A Vesoulis, Janine Rhoades, Pournika Muniyandi, Shayna Conner, Alison G Cahill, Amit M Mathur
OBJECTIVE: To evaluate the impact of delayed cord clamping (DCC) on need for inotropic support and mean arterial blood pressure (MABP). METHODS: This is a single-center, prospective case-control study of premature infants, born <32 weeks gestation, who underwent DCC in comparison to a matched control group who underwent immediate cord clamping (ICC). The primary outcomes were the differences in MABP and inotropic medication used over the first week of life. Secondary outcomes included the admission hemoglobin, need for blood transfusion, and rates of intraventricular hemorrhage (IVH)...
April 20, 2017: Journal of Maternal-fetal & Neonatal Medicine
https://www.readbyqxmd.com/read/28372507/assessment-of-sickness-severity-of-illness-in-neonates-review-of-various-neonatal-illness-scoring-systems
#6
Bhawandeep Garg, Deepak Sharma, Nazanin Farahbakhsh
Sickness severity scores are widely used for neonates admitted to neonatal intensive care units to predict severity of illness and risk of mortality and long-term outcome. These scores are also used frequently for quality assessment among various neonatal intensive care unit and hospital. Accurate and reliable measures of severity of illness are required for unbiased and reliable comparisons especially for benchmarking or comparative quality improvement care studies. These scores also serve to control for population differences when performing studies such as clinical trials, outcome evaluations, and evaluation of resource utilisation...
April 20, 2017: Journal of Maternal-fetal & Neonatal Medicine
https://www.readbyqxmd.com/read/28372504/placenta-previa-and-hemorrhage-the-placental-location-may-be-an-important-determinant-of-the-bleeding-amount
#7
Shigeki Matsubara, Yosuke Baba, Hironori Takahashi
No abstract text is available yet for this article.
April 20, 2017: Journal of Maternal-fetal & Neonatal Medicine
https://www.readbyqxmd.com/read/28372492/prenatally-diagnosed-congenital-portosystemic-shunts
#8
Bérengère Francois, Alain Lachaux, Fréderic Gottrand, Stéphanie De Smet
AIM: Congenital portosystemic shunts (CPSS) are rare, congenital malformations that are increasingly often discovered during the fetal period, and for which, the manifestations and evolution are poorly understood. The objective of this review is to describe the phenotype and evolution of forms diagnosed in the antenatal period. MATERIALS AND METHODS: We performed a systematic review of the literature cited in Pubmed between 1982 and 2016 for CPSS cases diagnosed during the fetal period...
April 20, 2017: Journal of Maternal-fetal & Neonatal Medicine
https://www.readbyqxmd.com/read/28372477/dilated-cerebral-venous-system-observed-in-growth-restricted-fetuses
#9
Joel Baron, Salvatore Andrea Mastrolia, Ilan Shelef, Dan Tirosh, Etty Daniel-Spiegel, Reli Hershkovitz
PURPOSE: The dilation of the fetal cerebral veins is a rare phenomenon that may be associated to a bad obstetric outcome, and is usually connected to antenatal thrombosis of the posterior dural venous sinuses. There are several descriptions of cerebral vein distension on magnetic resonance imaging (MRI), but all of them are detected postnatally. We present herein two cases of fetal antenatal cerebral dilation of the venous system, without any association to any sign of vein thrombosis, and a systematic review of literature regarding pathogenesis, diagnosis and outcomes associated to the antenatal detection of this condition with the use of MRI...
April 20, 2017: Journal of Maternal-fetal & Neonatal Medicine
https://www.readbyqxmd.com/read/28372476/the-introduction-of-umbilical-cord-lactate-measurement-and-associated-neonatal-outcomes-in-a-south-african-tertiary-hospital-labor-ward
#10
E R Allanson, R C Pattinson, E A Nathan, J E Dickinson
PURPOSE: To investigate the utility of umbilical artery (UA) lactate measurements in a South African hospital for assessing intrapartum care and predicting neonatal outcomes. MATERIALS AND METHODS: From 3 March-12 November 2014, we conducted a prospective cohort study of UA lactate levels at Kalafong Hospital, Pretoria, South Africa. Following birth, a UA blood sample (<0.5uL) was taken from a double-clamped segment of cord and the lactate measured. Maternal and neonatal characteristics and outcomes were recorded...
April 20, 2017: Journal of Maternal-fetal & Neonatal Medicine
https://www.readbyqxmd.com/read/28367651/outcomes-in-an-obstetrical-population-with-hereditary-thrombophilia-and-high-tobacco-use
#11
Byron Calhoun, Elizabeth Hoover, Dara Seybold, Mike Broce, Ashley Hill, Burk Shaible, Luis A Bracero
OBJECTIVE: The purpose of this study was to examine birth outcomes in women treated or untreated for thrombophilia during pregnancies affected or not by tobacco exposure. METHODS: This was a retrospective cohort study of consecutive women from a single maternal fetal medicine clinic who delivered between January 2009 and December 2013. We compared birth outcomes by four groups of thrombophilia and smoking combinations and then by treated or untreated groups. RESULTS: Of the 8889 pregnant women in this study, 113 had thrombophilia and 97 received treatment...
April 20, 2017: Journal of Maternal-fetal & Neonatal Medicine
https://www.readbyqxmd.com/read/28366040/how-often-an-isolated-cardiac-disproportion-predicts-a-coarctation-of-the-aorta-single-center-experience-and-systematic-review-of-the-literature
#12
Tullio Ghi, Andrea Dall'Asta, Claudio Cavalli, Letizia Galli, Adi Weiss, Giuseppe Pedrazzi, Christine Tita Kaihura, Nicola Volpe, Aldo Agnetti, Tiziana Frusca
BACKGROUND: Cardiac disproportion is considered as an indirect sign of coarctation of the aorta (CoA). In this review, we have reassessed the positive predictive value (PPV) of such finding for a postnatal confirmation of CoA. DATA SOURCES: All cases of isolated cardiac disproportion diagnosed in the four-chamber and/or three-vessel/three-vessel and trachea views (right/left sections >1.5) were included. Postnatal cardiac findings were recorded. Additionally, a systematic literature search (PubMed, EMBASE, Cochrane library, and the reference lists of identified articles) regarding the association between antenatally detected cardiac disproportion and postnatal confirmation of CoA was performed...
April 20, 2017: Journal of Maternal-fetal & Neonatal Medicine
https://www.readbyqxmd.com/read/28424020/the-utility-of-an-obesity-specific-small-for-gestational-age-standard-for-pregnancies-complicated-by-maternal-obesity
#13
Ruofan Yao, Sarah E Foster, Aaron B Caughey
INTRODUCTION: An obesity-specific standard for small for gestational age (SGA) pregnancies may help identify additional at risk pregnancies. METHODS: This was a retrospective cohort study of all non-anomalous singleton neonates born in Texas from 2006-2011. Analysis was limited to births between 34 and 42 weeks gestation. Two SGA birth weight standards (birth weight ≤ 10(th) centile) were generated, one using the entire population (SGApop) and another using obese pregnancies (SGAcust)...
April 19, 2017: Journal of Maternal-fetal & Neonatal Medicine
https://www.readbyqxmd.com/read/28423981/post-partum-follow-up-of-women-with-gestational-diabetes-mellitus-effectiveness-determinants-and-barriers
#14
Saleha Aziz, Tazeen Fatima Munim, Syeda Sadia Fatima
BACKGROUND: Despite the recommendations for postpartum blood glucose monitoring post gestational diabetes mellitus (GDM); scientific evidence reveals that these recommendations may not be fully complied to. This study aimed to follow-up women up to two years post-delivery with pregnancies complicated by GDM and healthy controls to assess this fact. METHODS: Women with GDM (n = 78) and normal glucose tolerant (n = 89) delivered in 2014 were followed up for two years...
April 19, 2017: Journal of Maternal-fetal & Neonatal Medicine
https://www.readbyqxmd.com/read/28423959/diabetic-pregnancy-maternal-and-fetal-docosahexaenoic-acid-a-review-of-existing-evidence
#15
Pauline Léveillé, Clémence Rouxel, Mélanie Plourde
OBJECTIVE: Docosahexaenoic acid (DHA) is vital for fetal development especially during the third trimester of gestation when the speed of fetal brain growth is at its peak. Diabetes modifies the maternal fatty acid profile, which may in turn change the quantity and/or quality of lipids transferred to the fetus. Neonates born to diabetic mothers might be more vulnerable to DHA deficiency leading to lower cognitive scores together with lower overall intellectual quotients when compared to control...
April 19, 2017: Journal of Maternal-fetal & Neonatal Medicine
https://www.readbyqxmd.com/read/28420274/comparison-of-serum-folate-25-oh-vitamin-d-and-calcium-levels-between-pregnants-with-and-without-fetal-anomaly-of-neural-tube-origin
#16
Hicran Acar Sirinoglu, Kaan Pakay, Murat Aksoy, Işil Turan Bakırci, Enis Ozkaya, Ilhan Sanverdi
AIM: The aim of this study was to compare serum folate, vitamin B12, 25-OH vitamin D and calcium levels between pregnants with and without fetal anomaly of neural tube origin. METHODS: One hundred seventy eight pregnants were recruited for this study. Pregnants with and without sonographically detected fetal anomaly of neural tube origin were compared in terms of serum folate, vitamin B12, 25-OH vitamin D and calcium levels. RESULTS: There were significant differences between groups with regard to age, serum 25 OH vitamin D, 1,25 OH vitamin D, folate, calcium and B 12 levels...
April 19, 2017: Journal of Maternal-fetal & Neonatal Medicine
https://www.readbyqxmd.com/read/28420276/the-influence-of-maternal-vaginal-flora-on-the-intestinal-colonization-in-newborns-and-3-month-old-infants
#17
Iwona Gabriel, Anita Olejek, Krystyna Stencel-Gabriel, Miroslaw Wielgoś
The role of maternal vaginal bacteria on the colonization of neonatal gut is still matter of discussion. Our aim was estimate the role of maternal vaginal flora on the development of intestinal flora in neonates and 3- months-old infants. 79 maternal-neonatal pairs were included in the study. Vaginal swabs were taken before the rupture of membranes after admission to the delivery ward. First neonatal stool (meconium) and stool at 3-months-old infants were collected and cultured. All samples were subject to a microbiological analysis for Streptococcus, Staphylococcus, Bifidobacterium, Clostridium (including Cl...
April 18, 2017: Journal of Maternal-fetal & Neonatal Medicine
https://www.readbyqxmd.com/read/28420272/resveratrol-suppresses-hyperoxia-induced-nucleocytoplasmic-shuttling-of-sirt1-and-ros-production-in-pbmc-from-preterm-infants-in-vitro
#18
Xi Yang, Wen-Bin Dong, Xiao-Ping Lei, Qing-Ping Li, Lian-Yu Zhang, Ling-Ping Zhang
OBJECTIVE: By assessing silent mating-type information regulation 2 homolog 1 (SIRT1) nucleocytoplasmic shuttling and reactive oxygen species (ROS) levels in peripheral blood mononuclear cells (PBMCs), this study aimed to explore the role of SIRT1 in premature infants after exposure to hyperoxia and assess the protective effects of resveratrol (Res). METHODS: Firstly, ROS levels as well as SIRT1 translocation and expression in PBMCs samples were evaluated from 40 premature infants with different oxygen amounts received at birth...
April 18, 2017: Journal of Maternal-fetal & Neonatal Medicine
https://www.readbyqxmd.com/read/28413896/congenital-malformations-palliative-care-and-postnatal-redirection-to-more-intensive-treatment-a-review-at-a-swiss-tertiary-center
#19
Ulrich Pfeifer, Deborah Gubler, Eva Bergstraesser, Dirk Bassler
PURPOSE: The so-called lethal malformations pose ethical challenges. Most affected fetuses die before or at birth. Live-born neonates commonly receive palliative care. If the postnatal course is better than expected, redirection towards more treatment may occur. We aimed to analyze this in a Swiss patient cohort. MATERIALS AND METHODS: Over 6 years, fetal malformation was suspected in 1113 cases. We identified patients prenatally assigned to palliative care, assessed pre- and postnatal diagnoses, and outcomes...
April 16, 2017: Journal of Maternal-fetal & Neonatal Medicine
https://www.readbyqxmd.com/read/28413891/safety-of-peripherally-inserted-central-catheters-during-pregnancy-a-retrospective-study
#20
Laura Jacques, Megan Foeller, Rahmouna Farez, Kristina Kaljo, Melodee Nugent, Pippa Simpson, Timothy Klatt
PURPOSE: We investigated the incidence of complications associated with peripherally inserted central line catheters, inserted using a standardized technique, during pregnancy and the postpartum period. MATERIALS AND METHODS: A retrospective case series was performed that included all pregnant and postpartum women who received peripherally inserted central catheters (PICCs) at a single institution between 2006 and 2014. Patient demographics and data on infectious, mechanical and thrombotic complications were collected...
April 16, 2017: Journal of Maternal-fetal & Neonatal Medicine
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