Masato Ito, Ayumi Sasaki, Mitsuhiro Haga, Ayaka Iwatani, Eri Nishimura, Hirokazu Arai, Nobuhiko Nagano, Shutaro Suga, Shunsuke Araki, Asami Konishi, Yoshihiro Onouchi, Fumihiko Namba
BACKGROUND: Bronchopulmonary dysplasia (BPD) has a lasting effect on the respiratory function of infants, imposing chronic health burdens. BPD is influenced by various prenatal, postnatal, and genetic factors. This study explored the connection between BPD and home oxygen therapy (HOT), and then we examined the association between HOT and a specific single-nucleotide polymorphism (SNP) in the hyaluronan and proteoglycan link protein 1 ( HAPLN1 ) gene among premature Japanese infants. MATERIALS AND METHODS: Prenatal and postnatal data from 212 premature infants were collected and analyzed by four SNPs (rs975563, rs10942332, rs179851, and rs4703570) around HAPLN1 using the TaqMan polymerase chain reaction method...
December 2024: Journal of Maternal-fetal & Neonatal Medicine