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Macromolecular Bioscience

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https://www.readbyqxmd.com/read/28809095/isocyanate-free-uv-crosslinked-poly-hydroxyurethane-networks-a-sustainable-approach-toward-highly-functional-antibacterial-gels
#1
Geng Hua, Karin Odelius
An increased sustainabile awarness has inspired the development of new polymeric networks in a remarkable way and this strive should be combined with environmentally concerned end-uses. Therefore, a UV-crosslinked polyhydroxyurethane film with antibacterial properties is developed. First, a hydroxyurethane precursor is synthesized using aminolysis condensation, circumventing the use of isocyanates. The films are subsequently crosslinked under solvent-free conditions through a UV-triggered thiol-ene mechanism...
August 15, 2017: Macromolecular Bioscience
https://www.readbyqxmd.com/read/28809089/inverted-quasi-spherical-droplets-on-polydopamine-tio2-substrates-for-enhancing-gene-delivery
#2
Seung-Hyun Kim, Mihyun Lee, Mira Cho, Il-Sun Kim, Kook In Park, Haeshin Lee, Jae-Hyung Jang
Devising efficient gene delivery systems is crucial to enhancing the therapeutic efficacy of gene-cell therapy approaches. Herein, inverted quasi-spherical (iQS) droplet systems, which enhance gene delivery efficiencies by reducing the path lengths of gene vectors, mediating motions of vectors at early stages, and raising the contact frequencies of vectors with cells, are developed by adopting the principle of 3D hanging-drop cell culture. Micrometer-sized polydopamine (pDA) holes are created on superhydrophobic titanium isopropoxide (TiO2 )-coated substrates by physical scraping; droplets are loaded on the pDA holes, and inversion of the substrate generates iQS droplets with large contact angles...
August 15, 2017: Macromolecular Bioscience
https://www.readbyqxmd.com/read/28809082/development-of-a-dual-functional-hydrogel-using-rgd-and-anti-vegf-aptamer
#3
Nan Zhao, Mark R Battig, Ming Xu, Xiuli Wang, Na Xiong, Yong Wang
Synthetic molecular libraries hold great potential to advance the biomaterial development. However, little effort is made to integrate molecules with molecular recognition abilities selected from different libraries into a single biomolecular material. The purpose of this work is to incorporate peptides and nucleic acid aptamers into a porous hydrogel to develop a dual-functional biomaterial. The data show that an anti-integrin peptide can promote the attachment and growth of endothelial cells in a 3D porous poly(ethylene glycol) hydrogel and an antivascular endothelial growth factor aptamer can sequester and release VEGF of high bioactivity...
August 15, 2017: Macromolecular Bioscience
https://www.readbyqxmd.com/read/28805040/hpma-copolymer-drug-conjugates-with-controlled-tumor-specific-drug-release
#4
REVIEW
Petr Chytil, Eva Koziolová, Tomáš Etrych, Karel Ulbrich
Over the past few decades, numerous polymer drug carrier systems are designed and synthesized, and their properties are evaluated. Many of these systems are based on water-soluble polymer carriers of low-molecular-weight drugs and compounds, e.g., cytostatic agents, anti-inflammatory drugs, or multidrug resistance inhibitors, all covalently bound to a carrier by a biodegradable spacer that enables controlled release of the active molecule to achieve the desired pharmacological effect. Among others, the synthetic polymer carriers based on N-(2-hydroxypropyl) methacrylamide (HPMA) copolymers are some of the most promising carriers for this purpose...
August 14, 2017: Macromolecular Bioscience
https://www.readbyqxmd.com/read/28805013/drug-free-macromolecular-therapeutics-induce-apoptosis-via-calcium-influx-and-mitochondrial-signaling-pathway
#5
Lian Li, Jiyuan Yang, Jiawei Wang, Jindřich Kopeček
Recently, an innovative paradigm has been proposed in macromolecular therapeutics for treatment of B-cell lymphomas that can specifically kill cancer cells without a drug. The design rationale of this drug-free macromolecular therapeutic (DFMT) system is crosslinking the cell surface receptor to initiate apoptosis. However, how the apoptosis signal is triggered after receptor hyper-crosslinking remains to be elucidated. Here, two pathways, calcium influx dependent pathway and mitochondrial signal pathway, are identified to play major roles in triggering the programmed cell death...
August 14, 2017: Macromolecular Bioscience
https://www.readbyqxmd.com/read/28805010/characterization-of-hydrogels-made-of-a-novel-spider-silk-protein-emasp1s-and-evaluation-for-3d-printing
#6
Christopher Thamm, Elise DeSimone, Thomas Scheibel
Recombinantly produced spider silk proteins have high potential for bioengineering and various biomedical applications because of their biocompatibility, biodegradability, and low immunogenicity. Here, the recently described small spider silk protein eMaSp1s is assembled into hydrogels, which can be 3D printed into scaffolds. Further, blending with a recombinantly produced MaSp2 derivative eADF4(C16) alters the mechanical properties of the resulting hydrogels. Different spider silk hydrogels also show a distinct recovery after a high shear stress deformation, exhibiting the tunability of their features for selected applications...
August 14, 2017: Macromolecular Bioscience
https://www.readbyqxmd.com/read/28776937/synthesis-and-evaluation-of-chloroquine-containing-dmaema-copolymers-as-efficient-anti-mirna-delivery-vectors-with-improved-endosomal-escape-and-antimigratory-activity-in-cancer-cells
#7
Ying Xie, Fei Yu, Weimin Tang, Bolutito Oluwole Alade, Zheng-Hong Peng, Yazhe Wang, Jing Li, David Oupický
Chloroquine-containing 2-(dimethylamino)ethyl methacrylate copolymers (PDCs) are synthesized by reversible addition-fragmentation chain-transfer polymerization. Systematic evaluation is performed to test the hypothesis that presence of chloroquine (CQ) in the PDC structure will improve miRNA delivery due to enhanced endosomal escape while simultaneously contribute to anticancer activity of PDC/miRNA polyplexes through inhibition of cancer cell migration. The results show that miRNA delivery efficiency is dependent both on the molecular weight and CQ...
August 4, 2017: Macromolecular Bioscience
https://www.readbyqxmd.com/read/28762636/blockage-of-wnt-%C3%AE-catenin-signaling-by-nanoparticles-reduces-survival-and-proliferation-of-cll-cells-in-vitro-preliminary-study
#8
Ida Franiak-Pietryga, Henryk Maciejewski, Barbara Ziemba, Dietmar Appelhans, Brigitte Voit, Tadeusz Robak, Magdalena Jander, Jacek Treliński, Maria Bryszewska, Maciej Borowiec
The Wnt/β-catenin signaling pathway is shown to play a significant role in the control of the survival, proliferation, and differentiation of hematopoietic cells. Studies have confirmed that aberrant activation of canonical Wnt signaling occurs in various forms of leukemia, and is crucial for chronic lymphocytic leukemia (CLL) pathogenesis. The aim of the study is to evaluate the influence of maltotriose (M3) modified fourth generation poly(propylene imine) dendrimers (PPI-G4) on Wnt/β-catenin pathway gene expression in CLL (MEC-1) cells and to compare these findings with those obtained with fludarabine (FA)...
August 1, 2017: Macromolecular Bioscience
https://www.readbyqxmd.com/read/28759159/peptosomes-for-vaccination-combining-antigen-and-adjuvant-in-polypept-o-ide-based-polymersomes
#9
Benjamin Weber, Cinja Kappel, Martin Scherer, Mark Helm, Matthias Bros, Stephan Grabbe, Matthias Barz
In this work, the first vaccine is reported based on a PeptoSome, which contains a model antigen (SIINFEKL) and adjuvant (CpG). PeptoSomes are polypept(o)ide-based polymersomes built of a block-copolymer with polysarcosine (PSar) as the hydrophilic block (X n = 111) and poly(benzyl-glutamic acid) (PGlu(OBn)) as the hydrophobic one (X n = 46). The polypept(o)ide is obtained with low dispersity index of 1.32 by controlled ring-opening polymerization. Vesicle formation by dual centrifugation technique allows for loading of vesicles up to 40 mol%...
July 31, 2017: Macromolecular Bioscience
https://www.readbyqxmd.com/read/28741860/autoinducer-sensing-microarrays-by-reporter-bacteria-encapsulated-in-hybrid-supramolecular-polysaccharide-hydrogels
#10
Ping Li, Xiaoqiu Dou, Mareike Müller, Chuanliang Feng, Matthew Wook Chang, Martin Frettlöh, Holger Schönherr
A generally applicable strategy to obtain mechanically robust hydrogels for the incorporation and containment of functional reporter bacteria for the microarray and microparticle-based detection and signaling of N-acyl homoserine lactone autoinducers (3OC12 HSL) at relevant concentrations is reported. For reinforcing hydrogels of 1,4-bi(phenylalanine-diglycol)-benzene (PDB), a hybrid hydrogel is formed by the combination of PDB self-assembly with Ca(2+) mediated alginate crosslinking. The different assembly mechanisms are shown not to interfere with each other and despite the more than four-fold increased moduli of the hydrogels, diffusion of autoinducers into the gels remains efficient and Escherichia coli pLuxR-green fluorescent protein (GFP) reporter bacteria are proliferating...
July 25, 2017: Macromolecular Bioscience
https://www.readbyqxmd.com/read/28737832/self-assembled-polyprodrug-amphiphile-for-subcutaneous-xenograft-tumor-inhibition-with-prolonged-acting-time-in-vivo
#11
Dong Chen, Yu Huang, Shuting Xu, Huangyong Jiang, Jieli Wu, Xin Jin, Xinyuan Zhu
Polymeric drug delivery system termed as "polyprodrug amphiphile" poly(2-methylacryloyloxyethyl phosphorylcholine)-b-poly(10-hydroxy-camptothecin methacrylate (pMPC-b-pHCPT) is developed for the prolonged-acting cancer therapy. It is obtained by two-step reversible addition-fragmentation chain transfer polymerization of zwitterionic monomer MPC and an esterase-responsive polymerizable prodrug methacrylic anhydride-CPT, respectively. This diblock polymer is composed of both antifouling (pMPC) and bioactive (pHCPT) segments and the drug is designed as a building block to construct the polymer skeleton directly...
July 24, 2017: Macromolecular Bioscience
https://www.readbyqxmd.com/read/28722358/chemoenzymatic-synthesis-of-polypeptides-for-use-as-functional-and-structural-materials
#12
REVIEW
Kousuke Tsuchiya, Keiji Numata
Polypeptides inspired by the natural functional and structural proteins present in living systems are promising materials for various fields in terms of their versatile functionality and physical properties. Designing and synthesizing mimetic sequences of specific peptide motifs in proteins are important for exploring the functionality of natural proteins. Chemoenzymatic polymerization, which utilizes aminolysis (i.e., the reverse reaction of hydrolysis catalyzed by proteases), is a useful technique for synthesizing artificial polypeptide materials and has several advantages, including facile synthesis protocols, environmental friendliness, scalability, and atom economy...
July 19, 2017: Macromolecular Bioscience
https://www.readbyqxmd.com/read/28714290/in-vitro-and-in-vivo-characterization-of-biodegradable-reactive-isocyanate-terminated-three-armed-and-hyperbranched-block-copolymeric-tissue-adhesives
#13
Agnieszka I Bochyńska, Gerjon Hannink, Jan J Rongen, Dirk W Grijpma, Pieter Buma
Tissue adhesives are an attractive class of biomaterials, which can serve as a treatment for meniscus tears. In this study, physicochemical and adhesive properties of novel biodegradable three-armed- and hyperbranched block copolymeric adhesives are evaluated. Additionally, their degradation in vitro and in vivo, and the tissue reaction after subcutaneous injection in rats are assessed. The developed adhesives have sufficient adhesive strength to meniscus tissue after curing (66-88 kPa). Networks based on the three-armed adhesive have tensile properties that are in the same range as human meniscus...
July 17, 2017: Macromolecular Bioscience
https://www.readbyqxmd.com/read/28714224/codelivery-for-paclitaxel-and-bcl-2-conversion-gene-by-phb-pdmaema-amphiphilic-cationic-copolymer-for-effective-drug-resistant-cancer-therapy
#14
Xiaoyuan Wang, Sing Shy Liow, Qiaoqiong Wu, Chuang Li, Cally Owh, Zibiao Li, Xian Jun Loh, Yun-Long Wu
Antiapoptotic Bcl-2 protein's upregulated expression is a key reason for drug resistance leading to failure of chemotherapy. In this report, a series of biocompatible amphiphilic cationic poly[(R)-3-hydroxybutyrate] (PHB)-b-poly(2-(dimethylamino)ethyl methacrylate) (PDMAEMA) copolymer, comprising hydrophobic PHB block and cationic PDMAEMA block, is designed to codeliver hydrophobic chemotherapeutic paclitaxel and Bcl-2 converting gene Nur77/ΔDBD with enhanced stability, due to the micelle formation by hydrophobic PHB segment...
July 17, 2017: Macromolecular Bioscience
https://www.readbyqxmd.com/read/28714139/simple-radical-polymerization-of-poly-alginate-graft-n-isopropylacrylamide-injectable-thermoresponsive-hydrogel-with-the-potential-for-localized-and-sustained-delivery-of-stem-cells-and-bioactive-molecules
#15
Sreekanth Pentlavalli, Philip Chambers, Binulal N Sathy, Michelle O'Doherty, Marine Chalanqui, Daniel J Kelly, Tammy Haut-Donahue, Helen O McCarthy, Nicholas J Dunne
In this study, thermoresponsive copolymers that are fully injectable, biocompatible, and biodegradable and are synthesized via graft copolymerization of poly(N-isopropylacrylamide) onto alginate using a free-radical reaction are presented. This new synthesis method does not involve multisteps or associated toxicity issues, and has the potential to reduce scale-up difficulties. Chemical and physical analyses verify the resultant graft copolymer structure. The lower critical solution temperature, which is a characteristic of sol-gel transition, is observed at 32 °C...
July 17, 2017: Macromolecular Bioscience
https://www.readbyqxmd.com/read/28691373/stromal-vascular-fraction-loaded-silk-fibroin-mats-effectively-support-the-survival-of-diabetic-mice-after-pancreatic-islet-transplantation
#16
Sara Perteghella, Barbara Vigani, Luca Mastracci, Federica Grillo, Barbara Antonioli, Marta Galuzzi, Marta Cecilia Tosca, Barbara Crivelli, Stefania Preda, Giuseppe Tripodo, Mario Marazzi, Theodora Chlapanidas, Maria Luisa Torre
The aim of this study is to assess whether stromal vascular fraction (SVF)-soaked silk fibroin nonwoven mats (silk-SVF) can preserve the functionality of encapsulated pancreatic endocrine cells (alginate-PECs) after transplantation in the subcutaneous tissue of diabetic mice. Silk scaffolds are selected to create an effective 3D microenvironment for SVF delivery in the subcutaneous tissue before diabetes induction: silk-SVF is subcutaneously implanted in the dorsal area of five healthy animals; after 15 d, mice are treated with streptozotocin to induce diabetes and then alginate-PECs are implanted on the silk-SVF...
July 10, 2017: Macromolecular Bioscience
https://www.readbyqxmd.com/read/28691369/comprehensive-examination-of-mechanical-and-diffusional-effects-on-cell-behavior-using-a-decoupled-3d-hydrogel-system
#17
Suntae Kim, Sung Bo Sim, Kangseok Lee, Chaenyung Cha
Hydrogels possess several physical and chemical properties suitable for engineering cellular environments for biomedical applications. Despite recent advances in hydrogel systems for cell culture, it is still a significant challenge to independently control the mechanical and diffusional properties of hydrogels, both of which are well known to influence various cell behaviors when using hydrogels as 3D cell culture systems. Controlling the crosslinking density of a hydrogel system to tune the mechanical properties inevitably affects their diffusional properties, as the crosslinking density and diffusion are often inversely correlated...
July 10, 2017: Macromolecular Bioscience
https://www.readbyqxmd.com/read/28683186/enzyme-induced-matrix-softening-regulates-hepatocarcinoma-cancer-cell-phenotypes
#18
Youyun Liang, Nicholas Edwin Clay, Kathryn M Sullivan, Jiayu Leong, Altug Ozcelikkale, Max H Rich, Min Kyung Lee, Mei-Hsiu Lai, Hojeong Jeon, Bumsoo Han, Yen Wah Tong, Hyunjoon Kong
The progression of cancer is often accompanied by changes in the mechanical properties of an extracellular matrix. However, limited efforts have been made to reproduce these biological events in vitro. To this end, this study demonstrates that matrix remodeling caused by matrix metalloproteinase (MMP)-1 regulates phenotypic activities and modulates radiosensitivity of cancer cells exclusively in a 3D matrix. In this study, hepatocarcinoma cells are cultured in a collagen-based gel tailored to present an elastic modulus of ≈4...
July 6, 2017: Macromolecular Bioscience
https://www.readbyqxmd.com/read/28683185/design-and-construction-of-a-smart-targeting-drug-delivery-system-based-on-phototriggered-competition-of-host-guest-interaction
#19
Dan Zhao, Xiaoqing Yi, Gongdao Yuan, Renxi Zhuo, Feng Li
A smart targeting drug delivery nanocarrier is successfully constructed based on phototriggered competition of host-guest interaction. The targeting motif, i.e., biotin is first concealed by β-cyclodextrin (β-CD) via host-guest interaction. When the nanoparticles are exposed to UV light, the cleavage of photosensitive groups results in the exposure of adamantane (Ad) groups initially located in the interior of nanoassemblies, and β-CDs capped on biotin ligands can be replaced by Ad because of the higher binding constant between Ad and β-CD than that between biotin and β-CD...
July 6, 2017: Macromolecular Bioscience
https://www.readbyqxmd.com/read/28683183/pegylated-dendritic-polyglycerol-conjugate-delivers-doxorubicin-to-the-parasitophorous-vacuole-in-leishmania-infantum-infections
#20
Camino Gutierrez-Corbo, Barbara Dominguez-Asenjo, Laura I Vossen, Yolanda Pérez-Pertejo, Maria A Muñoz-Fenández, Rafael Balaña-Fouce, Marcelo Calderón, Rosa M Reguera
Most drugs against visceral leishmaniasis must be administered parenterally. A controlled drug release at the target site can improve the efficacy and toxicity of antileishmanial drugs in clinical use. Amastigotes live and grow inside the parasitophorous vacuole of host resident macrophages. Therefore, antileishmanial drugs should accumulate in this compartment to kill the parasite and do not produce toxicity to the cell host. PEGylated dendritic polyglycerol conjugates (PG-PEG) can ensure a controlled drug release and the immune activation efficiency of the host...
July 6, 2017: Macromolecular Bioscience
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