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Macromolecular Bioscience

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https://www.readbyqxmd.com/read/29782701/tgf-%C3%AE-1-modified-hyaluronic-acid-poly-glycidol-hydrogels-for-chondrogenic-differentiation-of-human-mesenchymal-stromal-cells
#1
Thomas Böck, Verena Schill, Martin Krähnke, Andre F Steinert, Jörg Tessmar, Torsten Blunk, Jürgen Groll
In cartilage regeneration, the biomimetic functionalization of hydrogels with growth factors is a promising approach to improve the in vivo performance and furthermore the clinical potential of these materials. In order to achieve this without compromising network properties, multifunctional linear poly(glycidol) acrylate (PG-Acr) is synthesized and utilized as crosslinker for hydrogel formation with thiol-functionalized hyaluronic acid via Michael-type addition. As proof-of-principle for a bioactivation, transforming growth factor-beta 1 (TGF-β1) is covalently bound to PG-Acr via Traut's reagent which does not compromise the hydrogel gelation and swelling behavior...
May 21, 2018: Macromolecular Bioscience
https://www.readbyqxmd.com/read/29782700/nonionic-dendritic-and-carbohydrate-based-amphiphiles-self-assembly-and-transport-behavior
#2
Suchita Prasad, Katharina Achazi, Boris Schade, Rainer Haag, Sunil K Sharma
Herein, a new series of non-ionic dendritic and carbohydrate based amphiphiles is synthesized employing biocompatible starting materials and studied for supramolecular aggregate formation in aqueous solution. The dendritic amphiphiles 12 and 13 possessing poly(glycerol) [G2.0] as hydrophilic unit and C-10 and C-18 hydrophobic alkyl chains, respectively, exhibit low critical aggregation concentration (CAC) in the order of 10-5 m and hydrodynamic diameters in the 8-10 nm range and supplemented by cryogenic transmission electron microscopy...
May 21, 2018: Macromolecular Bioscience
https://www.readbyqxmd.com/read/29782698/morphology-regulation-in-redox-destructible-amphiphilic-block-copolymers-and-impact-on-intracellular-drug-delivery
#3
Raju Bej, Jayita Sarkar, Debes Ray, Vinod K Aswal, Suhrit Ghosh
In two ABA type amphiphilic block copolymers (P1, P2), the hydrophobic B block consists of a bioreducible segmented poly(disulfide) (PDS), while poly-N-isopropylacrylamide (PNIPAM) or poly(triethyleneglycol)methylether-methacrylate (PTEGMA) serve as the hydrophilic A blocks in P1 and P2, respectively, leading to the formation of polymersome and micelle, owing to the difference in the packing parameters. Both exhibit comparable doxorubicin (Dox) encapsulation efficiency, but glutathione (GSH) triggered release appears much faster from the polymersome than micelle owing to the complete degradation of the PDS segment in polymersome morphology unlike in micelle...
May 21, 2018: Macromolecular Bioscience
https://www.readbyqxmd.com/read/29782695/dual-ag-zno-decorated-micro-nanoporous-sulfonated-polyetheretherketone-with-superior-antibacterial-capability-and-biocompatibility-via-layer-by-layer-self-assembly-strategy
#4
Yi Deng, Lei Yang, Xiaobing Huang, Junhong Chen, Xiuyuan Shi, Weizhong Yang, Min Hong, Yuan Wang, Matthew S Dargusch, Zhi-Gang Chen
Polyetheretherketone is attractive for dental and orthopedic applications due to its mechanical attributes close to that of human bone; however, the lack of antibacterial capability and bioactivity of polyetheretherketone has substantially impeded its clinical applications. Here, a dual therapy implant coating is developed on the 3D micro-/nanoporous sulfonated polyetheretherketone via layer-by-layer self-assembly of Ag ions and Zn ions. Material characterization studies have indicated that nanoparticles consisting of elemental Ag and ZnO are uniformly incorporated on the porous sulfonated polyetheretherketone surface...
May 21, 2018: Macromolecular Bioscience
https://www.readbyqxmd.com/read/29756281/lightweight-highly-permeable-biocompatible-and-antiadhesive-composite-meshes-for-intraperitoneal-repairs
#5
Minhui Hu, Xidong Lin, Rongkang Huang, Keli Yang, Yeru Liang, Xingcai Zhang, Hui Wang, Dingcai Wu
Ventral hernia is a public health issue and millions of meshes are used to repair abdominal wall defects every year. Polypropylene-based composite meshes represent an important class of materials for intraperitoneal repair, but the meshes generally give rise to infection, seroma, migration, and adhesion, leading to severe consequence or even reoperation. Here, a facile and versatile one-way fabrication of lightweight, highly permeable, and biocompatible composite meshes with superior antiadhesion properties is proposed by modifying polypropylene meshes with well-defined polydopamine nanocoating...
May 14, 2018: Macromolecular Bioscience
https://www.readbyqxmd.com/read/29745057/fabrication-of-reduction-sensitive-amphiphilic-cyclic-brush-copolymer-for-controlled-drug-release
#6
Xiao-Yan Tu, Chao Meng, Xiao-Long Zhang, Miao-Ge Jin, Xian-Shuo Zhang, Xue-Zhi Zhao, Yun-Fei Wang, Li-Wei Ma, Bao-Yan Wang, Ming-Zhu Liu, Hua Wei
The cyclic brush polymers, due to the unique topological structure, have shown in the previous studies higher delivery efficacy than the bottlebrush analogues as carriers for drug and gene transfer. However, to the best of knowledge, the preparation of reduction-sensitive cyclic brush polymers for drug delivery applications remains unexplored. For this purpose, a reduction-sensitive amphiphilic cyclic brush copolymer, poly(2-hydroxyethyl methacrylate-g-poly(ε-caprolactone)-disulfide link-poly(oligoethyleneglycol methacrylate)) (P(HEMA-g-PCL-SS-POEGMA)) with reducible block junctions bridging the hydrophobic PCL middle layer and the hydrophilic POEGMA outer corona is designed and synthesized successfully in this study via a "grafting from" approach using sequential ring-opening polymerization (ROP) and atom transfer free radical polymerization (ATRP) from a cyclic multimacroinitiator PHEMA...
May 10, 2018: Macromolecular Bioscience
https://www.readbyqxmd.com/read/29745025/dentin-phosphoprotein-mimetic-peptide-nanofibers-promote-biomineralization
#7
Gulcihan Gulseren, Gulistan Tansik, Ruslan Garifullin, Ayse B Tekinay, Mustafa O Guler
Dentin phosphoprotein (DPP) is a major component of the dentin matrix playing crucial role in hydroxyapatite deposition during bone mineralization, making it a prime candidate for the design of novel materials for bone and tooth regeneration. The bioactivity of DPP-derived proteins is controlled by the phosphorylation and dephosphorylation of the serine residues. Here an enzyme-responsive peptide nanofiber system inducing biomineralization is demonstrated. It closely emulates the structural and functional properties of DPP and facilitates apatite-like mineral deposition...
May 10, 2018: Macromolecular Bioscience
https://www.readbyqxmd.com/read/29737012/an-extracellular-matrix-mimicking-hydrogel-for-full-thickness-wound-healing-in-diabetic-mice
#8
Xianyan Qin, Weizhen Qiao, Yuejing Wang, Tingyu Li, Xiang Li, Tao Gong, Zhi-Rong Zhang, Yao Fu
An extracellular matrix-mimicking hydrogel is developed consisting of a hyaluronan-derived component with anti-inflammatory activity, and a gelatin-derived component offering adhesion sites for cell anchorage. The in situ-forming hyaluronan-gelatin (HA-GEL) hydrogel displays a sponge-like microporous morphology. Also, HA-GEL shows a rapid swelling pattern reaching maximum weight swelling ratio within 10 min, while at the equilibrium state, fully swollen hydrogels display an exceedingly high water content with ≈2000% of the dry gel weight...
May 7, 2018: Macromolecular Bioscience
https://www.readbyqxmd.com/read/29736987/ionic-dependence-of-gelatin-hydrogel-architecture-explored-using-small-and-very-small-angle-neutron-scattering-technique
#9
Baohu Wu, Maria Siglreitmeier, Christian Debus, Dietmar Schwahn, Helmut Cölfen, Vitaliy Pipich
The hierarchical structure of gelatin hydrogels mimics a natural extracellular matrix and provides an optimized microenvironment for the growth of 3D structured tissue analogs. In the presence of metal ions, gelatin hydrogels exhibit various mechanical properties that are correlated with the molecular interactions and the hierarchical structure. The structure and structural response of gelatin hydrogels to variation of gelatin concentration, pH, or addition of metal ions are explored by small and very small angle neutron scattering over broad length scales...
May 7, 2018: Macromolecular Bioscience
https://www.readbyqxmd.com/read/29736908/poly-2-oxazoline-hydrogels-state-of-the-art-and-emerging-applications
#10
Tim R Dargaville, Jong-Ryul Park, Richard Hoogenboom
The synthesis of poly(2-oxazoline)s has been known since the 1960s. In the last two decades, they have risen in popularity thanks to improvements in their synthesis and the realization of their potential in the biomedical field due to their "stealth" properties, stimuli responsiveness, and tailorable properties. Even though the bulk of the research to date has been on linear forms of the polymer, they are also of interest for creating network structures due to the relatively easy introduction of reactive functional groups during synthesis that can be cross-linked under a variety of conditions...
May 7, 2018: Macromolecular Bioscience
https://www.readbyqxmd.com/read/29733551/folate-conjugated-and-dual-stimuli-responsive-mixed-micelles-loading-indocyanine-green-for-photothermal-and-photodynamic-therapy
#11
Yu-Ying Chien, Tung-Yun Wang, Po-Wen Liao, Wen-Chung Wu, Ching-Yi Chen
A folic acid targeted mixed micelle system based on co-assembly of poly(ε-caprolactone)-b-poly(methoxytri(ethylene glycol) methacrylate-co-N-(2-methacrylamido)ethyl folatic amide) and poly(ε-caprolactone)-b-poly(diethylene glycol monomethyl ether methacrylate) is developed to encapsulate indocyanine green (ICG) for photothermal therapy and photodynamic therapy. In this study, the use of folic acid is not only for specific cancer cell recognition, but also in virtue of the carboxylic acid on folic acid to regulate the pH-dependent thermal phase transition of polymeric micelles for controlled drug release...
May 7, 2018: Macromolecular Bioscience
https://www.readbyqxmd.com/read/29733514/injectable-hydrogels-for-cardiac-tissue-engineering
#12
REVIEW
Brisa Peña, Melissa Laughter, Susan Jett, Teisha J Rowland, Matthew R G Taylor, Luisa Mestroni, Daewon Park
In light of the limited efficacy of current treatments for cardiac regeneration, tissue engineering approaches have been explored for their potential to provide mechanical support to injured cardiac tissues, deliver cardio-protective molecules, and improve cell-based therapeutic techniques. Injectable hydrogels are a particularly appealing system as they hold promise as a minimally invasive therapeutic approach. Moreover, injectable acellular alginate-based hydrogels have been tested clinically in patients with myocardial infarction (MI) and show preservation of the left ventricular (LV) indices and left ventricular ejection fraction (LVEF)...
May 7, 2018: Macromolecular Bioscience
https://www.readbyqxmd.com/read/29732741/an-enzyme-responsive-turn-on-fluorescence-polymeric-superamphiphile-as-a-potential-visualizable-phosphate-prodrug-delivery-vehicle
#13
Xi Yang, Shihong Shen, Li Guo, Jidong Tan, Henxin Lei, Jianghan Wu, Lei Zhao, Tao Xiong, Youshen Wu, Yilong Cheng, Yanfeng Zhang
The development of inexpensive and highly efficient enzyme-responsive polymers has significantly contributed to targeted drug delivery systems. Here, a superamphiphile with a capability of fluorescent dissociation sensing is designed. It is constructed with negatively charged adenosine 5'-triphosphate (ATP) and negatively charged fluorescein diphosphate (FDP), which are used as fluorescence detection, and a cationic diblock copolymer methoxy-poly(ethylene glycol)113 -b-poly(2-dimethyl-aminoethyl methacrylate)70 ...
May 7, 2018: Macromolecular Bioscience
https://www.readbyqxmd.com/read/29732706/liposomes-camouflaged-redox-responsive-nanogels-to-resolve-the-dilemma-between-extracellular-stability-and-intracellular-drug-release
#14
Jinfeng Ma, Hongzhang Deng, Fuli Zhao, Liandong Deng, Weiwei Wang, Anjie Dong, Jianhua Zhang
Liposomes have shown great promises for pharmaceutical applications, but still suffer from the poor storage stability, undesirable drug leakage, and uncontrolled drug release. Herein, liposomes-camouflaged redox-responsive nanogels platform (denoted as "R-lipogels") is prepared to integrate the desirable features of sensitive nanogels into liposomes to circumvent their intrinsic issues. The results indicate that drug-loaded R-lipogels with controlled size and high stability not only can achieve a very high doxorubicin (DOX)-loading capacity (12...
May 7, 2018: Macromolecular Bioscience
https://www.readbyqxmd.com/read/29719124/graphene-oxide-decorated-microporous-polyetheretherketone-with-superior-antibacterial-capability-and-in-vitro-osteogenesis-for-orthopedic-implant
#15
Ling Ouyang, Yi Deng, Lei Yang, Xiuyuan Shi, Taosheng Dong, Youyi Tai, Weizhong Yang, Zhi-Gang Chen
Due to its similar elastic modulus of human bones, polyetheretherketone (PEEK) has been considered as an excellent cytocompatible material. However, the bioinertness, poor osteoconduction, and weak antibacterial activity of PEEK limit its wide applications in clinics. In this study, a facile strategy is developed to prepare graphene oxide (GO) modified sulfonated polyetheretherketone (SPEEK) (GO-SPEEK) through a simple dip-coating method. After detailed characterization, it is found that the GO closely deposits on the surface of PEEK, which is attributed to the π-π stacking interaction between PEEK and GO...
May 2, 2018: Macromolecular Bioscience
https://www.readbyqxmd.com/read/29700984/hemocompatible-and-bioactive-heparin-loaded-pcl-%C3%AE-tcp-fibrous-membranes-for-bone-tissue-engineering
#16
Morteza Alehosseini, Nasim Golafshan, Mahshid Kharaziha, Mohammadhossein Fathi, Hossein Edris
The combination of bioactive components such as calcium phosphates and fibrous structures are encouraging niche-mimetic keys for restoring bone defects. However, the importance of hemocompatibility of the membranes is widely ignored. Heparin-loaded nanocomposite poly(ε-caprolactone) (PCL)-α-tricalcium phosphate (α-TCP) fibrous membranes are developed to provide bioactive and hemocompatible constructs for bone tissue engineering. Nanocomposite membranes are optimized based on bioactivity, mechanical properties, and cell interaction...
April 27, 2018: Macromolecular Bioscience
https://www.readbyqxmd.com/read/29688620/zwitterionic-polymer-design-that-inhibits-aggregation-and-facilitates-insulin-refolding-mechanistic-insights-and-importance-of-hydrophobicity
#17
Robin Rajan, Yu Suzuki, Kazuaki Matsumura
The synthesis of a zwitterionic polymer, poly-sulfobetaine (poly-SPB), which shows remarkable efficiency in the suppression of insulin aggregation is described. Hydrophobic modification of the polymer results in almost complete inhibition at very low polymer concentrations. Further studies reveal that these polymers facilitate the complete retention of insulin's secondary structure, which is otherwise lost after incubation. Refolding studies show that addition of polymers to preaggregated insulin sample leads to the refolding of denatured insulin, indicating their potential to facilitate the refolding of the denatured proteins...
April 24, 2018: Macromolecular Bioscience
https://www.readbyqxmd.com/read/29688614/paclitaxel-loaded-polylactide-polyethylene-glycol-fibers-with-long-term-antitumor-activity-as-a-potential-drug-carrier-for-local-chemotherapy
#18
Johana Plch, Kristyna Venclikova, Olga Janouskova, Jan Hrabeta, Tomas Eckschlager, Katerina Kopeckova, Zuzana Hampejsova, Zuzana Bosakova, Jakub Sirc, Radka Hobzova
Local application of anticancer agents prolongs the presence time and increases the concentration of drug in the target place and therefore may reduce serious side effects compared to drug systemic administration. The preparation of fibrous materials of polylactide (PLA) and polyethylene glycol (PEG) loaded with paclitaxel (PTX, 1 or 10 wt%) is presented. Scanning electron microscopy proves that PTX is homogeneously incorporated into the fibers. The addition of PEG of various molecular weights (6, 20, or 35 kDa) ensures the release of significantly higher amounts of hydrophobic PTX in a prolonged release time compared to the fibers containing PTX only...
April 24, 2018: Macromolecular Bioscience
https://www.readbyqxmd.com/read/29687630/composite-pla-peg-nha-dexamethasone-scaffold-prepared-by-3d-printing-for-bone-regeneration
#19
Xiaoyuan Li, Yu Wang, Zigui Wang, Yanxin Qi, Linlong Li, Peibiao Zhang, Xuesi Chen, Yubin Huang
3D printing has become an essential part of bone tissue engineering and attracts great attention for the fabrication of bioactive scaffolds. Combining this rapid manufacturing technique with chemical precipitation, biodegradable 3D scaffold composed of polymer matrix (polylactic acid and polyethylene glycol), ceramics (nano hydroxyapatite), and drugs (dexamethasone (Dex)) is prepared. Results of water contact angle, differential scanning calorimeter, and mechanical tests confirm that incorporation of Dex leads to significantly improved wettability, higher crystallinity degree, and tunable degradation rates...
April 24, 2018: Macromolecular Bioscience
https://www.readbyqxmd.com/read/29687605/shape-memory-properties-and-enzymatic-degradability-of-poly-%C3%AE%C2%B5-caprolactone-based-polyurethane-urea-containing-phenylalanine-derived-chain-extender
#20
Rong Wang, Fanjun Zhang, Weiwei Lin, Wenkai Liu, Jiehua Li, Feng Luo, Yaning Wang, Hong Tan
Biodegradable shape memory polymers are promising biomaterials for minimally invasive surgical procedures. Herein, a series of linear biodegradable shape memory poly(ε-caprolactone) (PCL)-based polyurethane ureas (PUUs) containing a novel phenylalanine-derived chain extender is synthesized. The phenylalanine-derived chain extender, phenylalanine-hexamethylenediamine-phenylalanine (PHP), contains two chymotrypsin cleaving sites to enhance the enzymatic degradation of PUUs. The degradation rate, the crystallinity, and mechanical properties of PUUs are tailored by the content of PHP...
April 24, 2018: Macromolecular Bioscience
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