journal
https://read.qxmd.com/read/38536640/genetically-predicted-apolipoprotein-e-levels-with-the-risk-of-panvascular-diseases-a-mendelian-randomization-study
#1
JOURNAL ARTICLE
Yi-Ming Shi, Dian Ou, Jia-Ting Li, Le Bao, Xiao-Dan Liu, Wei Zhang, Huang Ding
The aim of this study was to comprehensively assess the causal relationship between the overall genetic effect of circulating ApoE levels and panvascular lesions using newer genome-wide association data and two-sample bidirectional Mendelian randomization (MR) analysis. Two-way MR using single-nucleotide polymorphisms of circulating ApoE as instrumental variables was performed using the highest-priority Genome-wide association study (GWAS) data, with factor-adjusted and data-corrected statistics, to estimate causal associations between circulating ApoE levels and 10 pan-vascular diseases in > 500,000 UK Biobank participants, > 400,000 participants of Finnish ancestry, and numerous participants in a consortium of predominantly European ancestry...
March 27, 2024: Cardiovascular Toxicology
https://read.qxmd.com/read/38530625/acute-high-output-heart-failure-with-pulmonary-hypertension-and-severe-liver-injury-caused-by-amlodipine-poisoning-a-case-report
#2
JOURNAL ARTICLE
Chenlong Wang, Qingcheng Zhu, Dingyu Tan, Joseph Walline, Yachao Wang
Acute high-output heart failure (HOHF) with pulmonary hypertension and liver injury caused by amlodipine poisoning is very rare. We report a 52-year-old woman who suffered from severe shock after an overdose of amlodipine. Hemodynamic monitoring showed that while her left ventricular systolic function and cardiac output were elevated, her systemic vascular resistance decreased significantly. At the same time, the size of her right heart, her central venous pressure, and the oxygen saturation of her central venous circulation all increased abnormally...
March 26, 2024: Cardiovascular Toxicology
https://read.qxmd.com/read/38512651/bmscs-derived-exosome-cish-alleviates-myocardial-infarction-by-inactivating-the-nf-%C3%AE%C2%BAb-pathway-to-stimulate-macrophage-m2-polarization
#3
JOURNAL ARTICLE
Minzhi Ouyang, Yang Yang, Guolong Yu, Jiling Zhao, Yi Peng
Current myocardial infarction (MI) treatments are suboptimal, necessitating deeper pathogenesis understanding of MI. This research explored how exosomes (Exo) derived from bone marrow mesenchymal stem cells (BMSCs) contribute to MI mitigation and their therapeutic potential. Isolated BMSCs was identified by microscope, flow cytometry, alizarin red and oil red O staining. Exo were identified by TEM, NTA and western blot. HE staining, masson staining, and cardiac function parameters were used to assess the cardiac function in MI mice...
March 21, 2024: Cardiovascular Toxicology
https://read.qxmd.com/read/38499940/development-and-validation-of-machine-learning-algorithms-to-predict-1-year-ischemic-stroke-and-bleeding-events-in-patients-with-atrial-fibrillation-and-cancer
#4
JOURNAL ARTICLE
Bang Truong, Jingyi Zheng, Lori Hornsby, Brent Fox, Chiahung Chou, Jingjing Qian
In this study, we leveraged machine learning (ML) approach to develop and validate new assessment tools for predicting stroke and bleeding among patients with atrial fibrillation (AFib) and cancer. We conducted a retrospective cohort study including patients who were newly diagnosed with AFib with a record of cancer from the 2012-2018 Surveillance, Epidemiology, and End Results (SEER)-Medicare database. The ML algorithms were developed and validated separately for each outcome by fitting elastic net, random forest (RF), extreme gradient boosting (XGBoost), support vector machine (SVM), and neural network models with tenfold cross-validation (train:test = 7:3)...
March 18, 2024: Cardiovascular Toxicology
https://read.qxmd.com/read/38466544/association-between-cancer-and-cardiovascular-toxicity-a-nationwide-cross-sectional-study-on-nhanes-1999-2018
#5
JOURNAL ARTICLE
Ruihuan Shen, Tong Zou
There is a dearth of evidence pertaining to the relationship of cardiovascular disease (CVD) and its subtype with adjudicated cancer, thereby limiting our understanding of the heightened risk of CVD resulting from long-term complications of cancer and its therapies. The aim of this study was to quantify the risks of CVD and its subtypes in adult cancer survivors compared with cancer-free controls in a nationwide cross-sectional study on Continuous National Health and Nutrition Examination Survey (NHANES). We included 44,442 participants ranging in age from 20 to 85 years...
March 11, 2024: Cardiovascular Toxicology
https://read.qxmd.com/read/38457021/arterial-stiffness-may-predict-subsequent-cancer-therapy-related-cardiac-dysfunction-in-breast-cancer-patients
#6
JOURNAL ARTICLE
Mürsel Şahin, Seher Nazlı Kazaz, Fatih Kartaler, Burcu Kodal, Seda Altuntaş, Elif Yüce, Oğuzhan Ekrem Turan, Merih Kutlu
Cancer therapy-related cardiac dysfunction (CTRCD) is still a serious problem. Existing risk scores are insufficient for risk classification, especially in low and medium-risk patients. This study aims to evaluate if arterial stiffness (AS) measurement, which is associated with most of the known risk factors, can be a useful parameter for predicting subsequent CTRCD in patients with breast cancer (BC). Patients with BC were included in the study. All patients' AS parameters such as pulse wave velocity (PWV), augmentation index (AIx), augmentation pressure (AP), and echocardiographic parameters were obtained before treatment...
March 8, 2024: Cardiovascular Toxicology
https://read.qxmd.com/read/38453799/m1-macrophage-derived-exosome-lncrna-pvt1-promotes-inflammation-and-pyroptosis-of-vascular-smooth-muscle-cells-in-abdominal-aortic-aneurysm-by-inhibiting-mir-186-5p-and-regulating-hmgb1
#7
JOURNAL ARTICLE
Jinhui Zhang, Xili Zhang, Xunqiang Liu, Huanjun Chen, Jifeng Wang, Min Ji
Abdominal aortic aneurysm (AAA) is a chronic vascular degenerative disease. Vascular smooth muscle cells (VSMCs) are essential for maintaining the integrity of healthy blood vessels. Macrophages play an important role in the inflammatory process of AAA. However, the effect of macrophage-derived exosome LncRNA PVT1 on VSMCs is unclear. Exosomes from M1 macrophages (M1φ-exos) were isolated and identified. The expression of LncRNA PVT1 in M1φ-exos was determined. AAA cell model was constructed by treating VSMCs with Ang-II...
March 7, 2024: Cardiovascular Toxicology
https://read.qxmd.com/read/38451349/subacute-exposure-to-gaseous-pollutants-from-diesel-engine-exhaust-attenuates-capsaicin-induced-cardio-pulmonary-reflex-responses-involving-oxidant-stress-mechanisms-in-adult-wistar-rats
#8
JOURNAL ARTICLE
Ravindran Revand, Aditya Dontham, Swarnabha Sarkar, Asmita Patil
Intravenous injection of capsaicin produces vagal-mediated protective cardio-pulmonary (CP) reflexes manifesting as tachypnea, bradycardia, and triphasic blood pressure (BP) response in anesthetized rats. Particulate matter from diesel engine exhaust has been reported to attenuate these reflexes. However, the effects of gaseous constituents of diesel exhaust are not known. Therefore, the present study was designed to investigate the effects of gaseous pollutants in diesel exhaust, on capsaicin-induced CP reflexes in rat model...
March 7, 2024: Cardiovascular Toxicology
https://read.qxmd.com/read/38448776/correlation-between-blood-cadmium-levels-and-platelet-characteristics-as-well-as-their-impact-on-susceptibility-to-coronary-heart-disease-findings-from-nhanes-2005-2018-data
#9
JOURNAL ARTICLE
Jichen Ci, Yuze Zhai, Benjun Wang, Weiwei Han, Bianfang Yu, Fan An
Investigating the correlation between blood cadmium levels, platelet characteristics, and susceptibility to coronary heart disease (CHD). Utilized NHANES 2005-2018 data with covariates such as age, sex, race, marital status, and socio-economic status. Blood cadmium served as the independent variable, while platelet count (PC) and mean platelet volume (MPV) were dependent variables. The average age of the participants was 68.77 ± 11.03 years, and 67.4% of them were male. The mean values for WBC, MPV, PC, and blood cadmium were 7...
March 6, 2024: Cardiovascular Toxicology
https://read.qxmd.com/read/38411851/cardiotoxicity-after-synthetic-cathinone-use-two-cases-a-case-series-and-scoping-review
#10
REVIEW
K L Groenewegen, F M J Gresnigt, J J Nugteren-van Lonkhuyzen, C den Haan, E J F Franssen, R K Riezebos, D Ohana, D W de Lange
The cardiotoxic effects of synthetic cathinones remain largely unknown. In this study, we present two cases, a case series and a scoping review, to explore synthetic cathinone associated cardiotoxicity. Case 1 involved a 28-year-old male with non-ST-elevation myocardial infarction after ingesting a substance containing 4-methylmethcathinone (4-MMC), 3-methylmethcathinon (3-MMC), and methcathinone. Case 2 involved a 49-year-old male with ventricular fibrillation after 4-methylmethcathinone ingestion, who was diagnosed with severe three-vessel disease...
February 27, 2024: Cardiovascular Toxicology
https://read.qxmd.com/read/38411850/effects-of-halloysite-nanotubes-and-multi-walled-carbon-nanotubes-on-kruppel-like-factor-15-mediated-downstream-events-in-mouse-hearts-after-intravenous-injection
#11
JOURNAL ARTICLE
Yimin Zhang, Yujia Cheng, Weichao Zhao, Fengmei Song, Yi Cao
Halloysite nanotubes (HNTs) are nanomaterials (NMs) derived from natural clays and have been considered as biocompatible NMs for biomedical uses. However, the cardiovascular toxicity of HNTs has not been thoroughly investigated. In this study, we compared the cardiotoxicity of HNTs and multi-walled carbon nanotubes (MWCNTs), focusing on the changes in Kruppel-like factor (KLF)-mediated signaling pathways. Mice were intravenously injected with 50 µg NMs, once a day, for 5 days, and then mouse hearts were removed for experiments...
February 27, 2024: Cardiovascular Toxicology
https://read.qxmd.com/read/38409566/evaluation-of-electrocardiogram-parameters-and-heart-rate-variability-during-blood-pressure-elevation-by-phenylephrine-in-cirrhotic-rats
#12
JOURNAL ARTICLE
Farzaneh Ketabchi, Mohammadreza Khoram, Amirreza Dehghanian
Cirrhotic cardiomyopathy is a myocardial disease that may go undetected in the early stages due to peripheral vasodilatation. The aim of the study was to evaluate the electrocardiogram (ECG) and heart rate variability (HRV) after raising blood pressure by phenylephrine injection in rats with liver cirrhosis. Twenty male Sprague-Dawley rats were divided into the Sham and common bile duct ligation (CBDL) groups. After 44 days, animals were anesthetized and the right femoral artery and vein catheterized. After a steady-state period, a bolus injection of phenylephrine (PHE, 10 μg/μl/IV, baroreflex maneuver) was followed by a slow injection of PHE (100 μg/ml/5 min/IV, sustained maneuver)...
February 26, 2024: Cardiovascular Toxicology
https://read.qxmd.com/read/38378972/hsa_circ_0032389-enhances-proliferation-and-migration-in-pdgf-bb-induced-human-aortic-vascular-smooth-muscle-cells
#13
JOURNAL ARTICLE
Haiyun Qian, Shengwei Ma, Qian Zhou, Chengang Lei
Circular RNA (circRNAs) has been confirmed to participate in atherosclerosis (AS) progression. However, the role and mechanism of hsa_circ_0032389 in AS process still need to be further revealed. This study evaluates the role and mechanism of hsa_circ_0032389 in AS process. Platelet-derived growth factor-BB (PDGF-BB) was used to induce human aortic vascular smooth muscle cells (HA-VSMCs). The expression levels of hsa_circ_0032389, microRNA (miR)-513a-5p, and fibroblast growth factor receptor substrate 2 (FRS2) were examined by quantitative real-time PCR...
February 20, 2024: Cardiovascular Toxicology
https://read.qxmd.com/read/38376772/uncovering-the-mechanism-of-chinese-hawthorn-leaf-on-myocardial-ischemia-based-on-network-pharmacology-molecular-docking-verification-and-in-vitro-studies
#14
JOURNAL ARTICLE
Jingyun Gao, Yueyue Wang, Hui Xiong, Shengnan Zhao, Mingmei He, Meiting He, Haifeng Pan
Hawthorn leaf has shown therapeutic effects in the patients with myocardial ischemia. Our study combines network pharmacology, molecular docking techniques, and in vitro experiment with the aim of revealing the mechanism of hawthorn leaves in the treatment of myocardial ischemia. The active ingredients and corresponding targets of hawthorn leaf through Traditional Chinese Medicine System Pharmacology and Swiss Target Prediction databases. Targets related to myocardial ischemia were retrieved by Gene Card, Online Mendelian Inheritance in Man, Disgenet, and Therapeutic Targets Database databases...
February 20, 2024: Cardiovascular Toxicology
https://read.qxmd.com/read/38376771/circrna_102046-affects-the-occurrence-and-development-of-ischemic-stroke-by-regulating-the-mir-493-5p-rock1-signaling
#15
JOURNAL ARTICLE
Wentao He, Yuanyuan Cheng, Yujie Lai
In our previous studies, the results have revealed that circRNA_102046 is significantly upregulated in plasma of patients with ischemic stroke, which closely related to NIHSS score. Human neural stem cells (hNSCs) were used for characterization and subcellular localization of circRNA_102046, and hNSCs OGD/R model was generated. The proliferation of cells was examined by CCK-8 assay. The expression levels of associated molecules were evaluated using RT-qPCR, immunofluorescence staining or western blotting. The binding and co-localization of associated molecules were also evaluated by RIP and FISH assay...
February 20, 2024: Cardiovascular Toxicology
https://read.qxmd.com/read/38369677/potential-effects-of-orally-ingesting-polyethylene-terephthalate-microplastics-on-the-mouse-heart
#16
JOURNAL ARTICLE
Tao Lu, Desheng Li, Xiaoqing Yuan, Zhenzhen Wang, Zhuang Shao, Xiaotian Feng, Chen Yang, Huan Liu, Guanqing Zhang, Yue Wang, Xiaohan Liu, Ling Zhou, Maolei Xu
Polyethylene terephthalate microplastics (PET MPs) are widespread in natural environment, and can enter organisms and accumulate in the body, but its toxicity has not been well studied. Therefore, in order to investigate the toxic effects of PET microplastics on mammals, this study investigated the toxic effects of PET MPs on ICR mice and H9C2 cells by different treatment groups. The results indicated the cardiac tissue of mice in the PET-H (50 µg/mL) group showed significant capillary congestion, myocardial fiber breakage, and even significant fibrosis compared to the PET-C (control) group (P < 0...
February 19, 2024: Cardiovascular Toxicology
https://read.qxmd.com/read/38356081/heavy-metal-scavenger-metallothionein-rescues-against-cold-stress-evoked-myocardial-contractile-anomalies-through-regulation-of-mitophagy
#17
JOURNAL ARTICLE
Zhaohui Pei, Yayuan Xiong, Shasha Jiang, Rui Guo, Wei Jin, Jun Tao, Zhenzhong Zhang, Yingmei Zhang, Yunzeng Zou, Yan Gong, Jun Ren
Cold stress prompts an increased prevalence of cardiovascular morbidity yet the underneath machinery remains unclear. Oxidative stress and autophagy appear to contribute to cold stress-induced cardiac anomalies. Our present study evaluated the effect of heavy metal antioxidant metallothionein on cold stress (4 °C)-induced in cardiac remodeling and contractile anomalies and cell signaling involved including regulation of autophagy and mitophagy. Cold stress (3 weeks) prompted interstitial fibrosis, mitochondrial damage (mitochondrial membrane potential and TEM ultrastructure), oxidative stress (glutathione, reactive oxygen species and superoxide), lipid peroxidation, protein injury, elevated left ventricular (LV) end systolic and diastolic diameters, decreased fractional shortening, ejection fraction, Langendorff heart function, cardiomyocyte shortening, maximal velocities of shortening/relengthening, and electrically stimulated intracellular Ca2+ rise along with elongated relaxation duration and intracellular Ca2+ clearance, the responses of which were overtly attenuated or mitigated by metallothionein...
February 14, 2024: Cardiovascular Toxicology
https://read.qxmd.com/read/38347287/comparative-in-vitro-study-of-the-cytotoxic-effects-of-doxorubicin-s-main-metabolites-on-cardiac-ac16-cells-versus-the-parent-drug
#18
JOURNAL ARTICLE
Ana Reis-Mendes, Cláudia Vitorino-Oliveira, Mariana Ferreira, Félix Carvalho, Fernando Remião, Emília Sousa, Maria de Lourdes Bastos, Vera Marisa Costa
Doxorubicin (DOX; also known as adriamycin) serves as a crucial antineoplastic agent in cancer treatment; however, its clinical utility is hampered by its' intrinsic cardiotoxicity. Although most DOX biotransformation occurs in the liver, a comprehensive understanding of the impact of DOX biotransformation and its' metabolites on its induced cardiotoxicity remains to be fully elucidated. This study aimed to explore the role of biotransformation and DOX's main metabolites in its induced cardiotoxicity in human differentiated cardiac AC16 cells...
February 13, 2024: Cardiovascular Toxicology
https://read.qxmd.com/read/38340234/effects-of-electronic-cigarette-vaping-on-cardiac-and-vascular-function-and-post-myocardial-infarction-remodeling-in-rats
#19
JOURNAL ARTICLE
Wangde Dai, Jianru Shi, Prabha Siddarth, Juan Carreno, Michael T Kleinman, David A Herman, Rebecca J Arechavala, Samantha Renusch, Irene Hasen, Amanda Ting, Robert A Kloner
The effect of electronic cigarette (E-cig) vaping on cardiac and vascular function during the healing phase of myocardial infarction (MI), and post-MI remodeling was investigated. Sprague Dawley rats were subjected to left coronary artery ligation to induce MI. One week later, rats were randomized to receive either 12 weeks of exposure to purified air (n = 37) or E-cig vapor (15 mg/ml of nicotine) (n = 32). At 12 weeks, cardiac and vascular function, and post-MI remodeling were assessed...
February 10, 2024: Cardiovascular Toxicology
https://read.qxmd.com/read/38324115/management-of-fluoropyrimidine-induced-cardiac-adverse-outcomes-following-cancer-treatment
#20
REVIEW
Mohsen Rajaeinejad, Peyvand Parhizkar-Roudsari, Mehran Khoshfetrat, Mohammad Hassan Kazemi-Galougahi, Reza Mosaed, Rasta Arjmand, Seyed Abolfazl Mohsenizadeh, Babak Arjmand
Advancements in cancer treatments have improved survival rates but have also led to increased cardiotoxicities, which can cause adverse cardiovascular events or worsen pre-existing conditions. Herein, cardiotoxicity is a severe adverse effect of 5-fluorouracil (5-FU) therapy in cancer patients, with reported incidence rates ranging from 1 to 20%. Some studies have also suggested subclinical effects and there are reports which have documented instances of cardiac arrest or sudden death during 5-FU treatment, highlighting the importance of timely management of cardiovascular symptoms...
February 7, 2024: Cardiovascular Toxicology
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