journal
MENU ▼
Read by QxMD icon Read
search

Biomechanics and Modeling in Mechanobiology

journal
https://www.readbyqxmd.com/read/28432448/resistance-to-radial-expansion-limits-muscle-strain-and-work
#1
E Azizi, A R Deslauriers, N C Holt, C E Eaton
The collagenous extracellular matrix (ECM) of skeletal muscle functions to transmit force, protect sensitive structures, and generate passive tension to resist stretch. The mechanical properties of the ECM change with age, atrophy, and neuromuscular pathologies, resulting in an increase in the relative amount of collagen and an increase in stiffness. Although numerous studies have focused on the effect of muscle fibrosis on passive muscle stiffness, few have examined how these structural changes may compromise contractile performance...
April 21, 2017: Biomechanics and Modeling in Mechanobiology
https://www.readbyqxmd.com/read/28429161/on-the-in-vivo-function-of-the-mitral-heart-valve-leaflet-insights-into-tissue-interstitial-cell-biomechanical-coupling
#2
Chung-Hao Lee, Will Zhang, Kristen Feaver, Robert C Gorman, Joseph H Gorman, Michael S Sacks
There continues to be a critical need for developing data-informed computational modeling techniques that enable systematic evaluations of mitral valve (MV) function. This is important for a better understanding of MV organ-level biomechanical performance, in vivo functional tissue stresses, and the biosynthetic responses of MV interstitial cells (MVICs) in the normal, pathophysiological, and surgically repaired states. In the present study, we utilized extant ovine MV population-averaged 3D fiducial marker data to quantify the MV anterior leaflet (MVAL) deformations in various kinematic states...
April 20, 2017: Biomechanics and Modeling in Mechanobiology
https://www.readbyqxmd.com/read/28424904/nanoindentation-response-of-cortical-bone-dependency-of-subsurface-voids
#3
Masoud Ramezanzadehkoldeh, Bjørn Skallerud
Nanoindentation test results in the axial direction of mouse femurs were the basis for the current study. Although the majority of the nanoindentation curves showed a reasonable consistency, some curves showed a significantly softer response. Detailed investigation, using focused ion beam-scanning electron microscopy, provided that the softer response is due to subsurface cavities such as lacunae. Finite element models were developed to simulate the nanoindentation of mice femur cortical bone samples with and without the incorporation of a single lacuna underneath the bone surface...
April 19, 2017: Biomechanics and Modeling in Mechanobiology
https://www.readbyqxmd.com/read/28421364/an-ovine-in-vivo-framework-for-tracheobronchial-stent-analysis
#4
Donnacha J McGrath, Anja Lena Thiebes, Christian G Cornelissen, Mary B O'Shea, Barry O'Brien, Stefan Jockenhoevel, Mark Bruzzi, Peter E McHugh
Tracheobronchial stents are most commonly used to restore patency to airways stenosed by tumour growth. Currently all tracheobronchial stents are associated with complications such as stent migration, granulation tissue formation, mucous plugging and stent strut fracture. The present work develops a computational framework to evaluate tracheobronchial stent designs in vivo. Pressurised computed tomography is used to create a biomechanical lung model which takes into account the in vivo stress state, global lung deformation and local loading from pressure variation...
April 19, 2017: Biomechanics and Modeling in Mechanobiology
https://www.readbyqxmd.com/read/28405768/efficient-isogeometric-thin-shell-formulations-for-soft-biological-materials
#5
Farshad Roohbakhshan, Roger A Sauer
This paper presents three different constitutive approaches to model thin rotation-free shells based on the Kirchhoff-Love hypothesis. One approach is based on numerical integration through the shell thickness while the other two approaches do not need any numerical integration and so they are computationally more efficient. The formulation is designed for large deformations and allows for geometrical and material nonlinearities, which makes it very suitable for the modeling of soft tissues. Furthermore, six different isotropic and anisotropic material models, which are commonly used to model soft biological materials, are examined for the three proposed constitutive approaches...
April 12, 2017: Biomechanics and Modeling in Mechanobiology
https://www.readbyqxmd.com/read/28389829/modelling-apical-columnar-epithelium-mechanics-from-circumferential-contractile-fibres
#6
A R B Boyd, S Moore, J E Sader, P V S Lee
Simple columnar epithelia are formed by individual epithelial cells connecting together to form single cell high sheets. They are a main component of many important body tissues and are heavily involved in both normal and cancerous cell activities. Prior experimental observations have identified a series of contractile fibres around the circumference of a cross section located in the upper (apical) region of each cell. While other potential mechanisms have been identified in both the experimental and theoretical literature, these circumferential fibres are considered to be the most likely mechanism controlling movement of this cross section...
April 7, 2017: Biomechanics and Modeling in Mechanobiology
https://www.readbyqxmd.com/read/28386685/a-machine-learning-approach-to-investigate-the-relationship-between-shape-features-and-numerically-predicted-risk-of-ascending-aortic-aneurysm
#7
Liang Liang, Minliang Liu, Caitlin Martin, John A Elefteriades, Wei Sun
Geometric features of the aorta are linked to patient risk of rupture in the clinical decision to electively repair an ascending aortic aneurysm (AsAA). Previous approaches have focused on relationship between intuitive geometric features (e.g., diameter and curvature) and wall stress. This work investigates the feasibility of a machine learning approach to establish the linkages between shape features and FEA-predicted AsAA rupture risk, and it may serve as a faster surrogate for FEA associated with long simulation time and numerical convergence issues...
April 6, 2017: Biomechanics and Modeling in Mechanobiology
https://www.readbyqxmd.com/read/28378119/bovine-and-degenerated-human-annulus-fibrosus-a-microstructural-and-micromechanical-comparison
#8
Claudio Vergari, Daniel Chan, Andrew Clarke, Jessica C Mansfield, Judith R Meakin, Peter C Winlove
The complex structure of the annulus fibrosus is strongly related to its mechanical properties. Recent work showed that it is possible to observe the relative movement of fibre bundles in loaded cow tail annulus; the aim of this work was to describe and quantify annulus fibrosus micromechanics in degenerated human disc, and compare it with cow tail annulus, an animal model often used in the literature. Second harmonic generation was used to image the collagen matrix in twenty strips of annulus fibrosus harvested from intervertebral disc of seven patients undergoing surgery...
April 4, 2017: Biomechanics and Modeling in Mechanobiology
https://www.readbyqxmd.com/read/28374083/mimetization-of-the-elastic-properties-of-cancellous-bone-via-a-parameterized-cellular-material
#9
Lucas Colabella, Adrián P Cisilino, Guillaume Häiat, Piotr Kowalczyk
Bone tissue mechanical properties and trabecular microarchitecture are the main factors that determine the biomechanical properties of cancellous bone. Artificial cancellous microstructures, typically described by a reduced number of geometrical parameters, can be designed to obtain a mechanical behavior mimicking that of natural bone. In this work, we assess the ability of the parameterized microstructure introduced by Kowalczyk (Comput Methods Biomech Biomed Eng 9:135-147, 2006. doi: 10.1080/10255840600751473 ) to mimic the elastic response of cancellous bone...
April 3, 2017: Biomechanics and Modeling in Mechanobiology
https://www.readbyqxmd.com/read/28364199/flow-dynamics-and-energy-efficiency-of-flow-in-the-left-ventricle-during-myocardial-infarction
#10
Vivek Vasudevan, Adriel Jia Jun Low, Sarayu Parimal Annamalai, Smita Sampath, Kian Keong Poh, Teresa Totman, Muhammad Mazlan, Grace Croft, A Mark Richards, Dominique P V de Kleijn, Chih-Liang Chin, Choon Hwai Yap
Cardiovascular disease is a leading cause of death worldwide, where myocardial infarction (MI) is a major category. After infarction, the heart has difficulty providing sufficient energy for circulation, and thus, understanding the heart's energy efficiency is important. We induced MI in a porcine animal model via circumflex ligation and acquired multiple-slice cine magnetic resonance (MR) images in a longitudinal manner-before infarction, and 1 week (acute) and 4 weeks (chronic) after infarction. Computational fluid dynamic simulations were performed based on MR images to obtain detailed fluid dynamics and energy dynamics of the left ventricles...
March 31, 2017: Biomechanics and Modeling in Mechanobiology
https://www.readbyqxmd.com/read/28361294/image-based-multiscale-mechanical-modeling-shows-the-importance-of-structural-heterogeneity-in-the-human-lumbar-facet-capsular-ligament
#11
Vahhab Zarei, Chao J Liu, Amy A Claeson, Taner Akkin, Victor H Barocas
The lumbar facet capsular ligament (FCL) primarily consists of aligned type I collagen fibers that are mainly oriented across the joint. The aim of this study was to characterize and incorporate in-plane local fiber structure into a multiscale finite element model to predict the mechanical response of the FCL during in vitro mechanical tests, accounting for the heterogeneity in different scales. Characterization was accomplished by using entire-domain polarization-sensitive optical coherence tomography to measure the fiber structure of cadaveric lumbar FCLs ([Formula: see text])...
March 30, 2017: Biomechanics and Modeling in Mechanobiology
https://www.readbyqxmd.com/read/28357604/affine-kinematics-in-planar-fibrous-connective-tissues-an-experimental-investigation
#12
C Jayyosi, J-S Affagard, G Ducourthial, C Bonod-Bidaud, B Lynch, S Bancelin, F Ruggiero, M-C Schanne-Klein, J-M Allain, K Bruyère-Garnier, M Coret
The affine transformation hypothesis is usually adopted in order to link the tissue scale with the fibers scale in structural constitutive models of fibrous tissues. Thanks to the recent advances in imaging techniques, such as multiphoton microscopy, the microstructural behavior and kinematics of fibrous tissues can now be monitored at different stretching within the same sample. Therefore, the validity of the affine hypothesis can be investigated. In this paper, the fiber reorientation predicted by the affine assumption is compared to experimental data obtained during mechanical tests on skin and liver capsule coupled with microstructural imaging using multiphoton microscopy...
March 29, 2017: Biomechanics and Modeling in Mechanobiology
https://www.readbyqxmd.com/read/28343260/urethral-lumen-occlusion-by-artificial-sphincteric-devices-a-computational-biomechanics-approach
#13
Arturo Nicola Natali, Emanuele Luigi Carniel, Chiara Giulia Fontanella, Silvia Todros, Giulia Maria De Benedictis, Maria Angela Cerruto, Walter Artibani
The action induced by artificial sphincteric devices to provide urinary continence is related to the problem of evaluating the interaction between the occlusive cuff and the urethral duct. The intensity and distribution of the force induced within the region of application determine a different occlusion process and potential degradation of the urethral tissue, mostly at the borders of the cuff. This problem is generally considered in the light of clinical and surgical operational experience, while a valid cooperation is established with biomechanical competences by means of experimental and numerical investigation...
March 25, 2017: Biomechanics and Modeling in Mechanobiology
https://www.readbyqxmd.com/read/28343259/numerical-and-experimental-analysis-of-the-transitional-flow-across-a-real-stenosis
#14
R Agujetas, C Ferrera, A C Marcos, J P Alejo, J M Montanero
In this paper, we present a numerical study of the pulsatile transitional flow crossing a severe real stenosis located right in front of the bifurcation between the right subclavian and right common carotid arteries. The simulation allows one to determine relevant features of this subject-specific flow, such as the pressure waves in the right subclavian and right common carotid arteries. We explain the subclavian steal syndrome suffered by the patient in terms of the drastic pressure drop in the right subclavian artery...
March 25, 2017: Biomechanics and Modeling in Mechanobiology
https://www.readbyqxmd.com/read/28315975/spatial-patterns-and-frequency-distributions-of-regional-deformation-in-the-healthy-human-lung
#15
Daniel E Hurtado, Nicolás Villarroel, Carlos Andrade, Jaime Retamal, Guillermo Bugedo, Alejandro Bruhn
Understanding regional deformation in the lung has long attracted the medical community, as parenchymal deformation plays a key role in respiratory physiology. Recent advances in image registration make it possible to noninvasively study regional deformation, showing that volumetric deformation in healthy lungs follows complex spatial patterns not necessarily shared by all subjects, and that deformation can be highly anisotropic. In this work, we systematically study the regional deformation in the lungs of eleven human subjects by means of in vivo image-based biomechanical analysis...
March 18, 2017: Biomechanics and Modeling in Mechanobiology
https://www.readbyqxmd.com/read/28289916/predicting-tenocyte-expression-profiles-and-average-molecular-concentrations-in-achilles-tendon-ecm-from-tissue-strain-and-fiber-damage
#16
Arash Mehdizadeh, Bruce S Gardiner, Michael Lavagnino, David W Smith
In this study, we propose a method for quantitative prediction of changes in concentrations of a number of key signaling, structural and effector molecules within the extracellular matrix of tendon. To achieve this, we introduce the notion of elementary cell responses (ECRs). An ECR defines a normal reference secretion profile of a molecule by a tenocyte in response to the tenocyte's local strain. ECRs are then coupled with a model for mechanical damage of tendon collagen fibers at different straining conditions of tendon and then scaled up to the tendon tissue level for comparison with experimental observations...
March 13, 2017: Biomechanics and Modeling in Mechanobiology
https://www.readbyqxmd.com/read/28289915/numerical-modeling-of-hemodynamics-scenarios-of-patient-specific-coronary-artery-bypass-grafts
#17
Francesco Ballarin, Elena Faggiano, Andrea Manzoni, Alfio Quarteroni, Gianluigi Rozza, Sonia Ippolito, Carlo Antona, Roberto Scrofani
A fast computational framework is devised to the study of several configurations of patient-specific coronary artery bypass grafts. This is especially useful to perform a sensitivity analysis of the hemodynamics for different flow conditions occurring in native coronary arteries and bypass grafts, the investigation of the progression of the coronary artery disease and the choice of the most appropriate surgical procedure. A complete pipeline, from the acquisition of patient-specific medical images to fast parameterized computational simulations, is proposed...
March 13, 2017: Biomechanics and Modeling in Mechanobiology
https://www.readbyqxmd.com/read/28289914/firecracker-eye-exposure-experimental-study-and-simulation
#18
Chiara Clemente, Luca Esposito, Domenico Speranza, Nicola Bonora
Understanding the mechanisms of traumatic ocular injury is helpful to make accurate diagnoses before the symptoms emerge and to develop specific eye protection. The comprehension of the dynamics of primary blast injury mechanisms is a challenging issue. The question is whether the pressure wave propagation and reflection alone could cause ocular damage. To date, there are dissenting opinions and no conclusive evidence thereupon. A previous numerical investigation of blast trauma highlighted the dynamic effect of pressure propagation and its amplification by the geometry of the bony orbit, inducing a resonance cavity effect and a standing wave hazardous for eye tissues...
March 13, 2017: Biomechanics and Modeling in Mechanobiology
https://www.readbyqxmd.com/read/28265781/trabecular-deformations-during-screw-pull-out-a-micro-ct-study-of-lapine-bone
#19
Thomas Joffre, Per Isaksson, Philip Procter, Cecilia Persson
The mechanical fixation of endosseous implants, such as screws, in trabecular bone is challenging because of the complex porous microstructure. Development of new screw designs to improve fracture fixation, especially in high-porosity osteoporotic bone, requires a profound understanding of how the structural system implant/trabeculae interacts when it is subjected to mechanical load. In this study, pull-out tests of screw implants were performed. Screws were first inserted into the trabecular bone of rabbit femurs and then pulled out from the bone inside a computational tomography scanner...
March 6, 2017: Biomechanics and Modeling in Mechanobiology
https://www.readbyqxmd.com/read/28258413/viscosity-and-haemodynamics-in-a-late-gestation-rat-feto-placental-arterial-network
#20
Nikhilesh Bappoo, Lachlan J Kelsey, Louis Parker, Tim Crough, Carmel M Moran, Adrian Thomson, Megan C Holmes, Caitlin S Wyrwoll, Barry J Doyle
The placenta is a transient organ which develops during pregnancy to provide haemotrophic support for healthy fetal growth and development. Fundamental to its function is the healthy development of vascular trees in the feto-placental arterial network. Despite the strong association of haemodynamics with vascular remodelling mechanisms, there is a lack of computational haemodynamic data that may improve our understanding of feto-placental physiology. The aim of this work was to create a comprehensive 3D computational fluid dynamics model of a substructure of the rat feto-placental arterial network and investigate the influence of viscosity on wall shear stress (WSS)...
March 3, 2017: Biomechanics and Modeling in Mechanobiology
journal
journal
39992
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"