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Biomechanics and Modeling in Mechanobiology

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https://www.readbyqxmd.com/read/28929388/fiber-reinforced-computational-model-of-the-aortic-root-incorporating-thoracic-aorta-and-coronary-structures
#1
Hossein Mohammadi, Raymond Cartier, Rosaire Mongrain
Cardiovascular diseases are still the leading causes of death in the developed world. The decline in the mortality associated with circulatory system diseases is accredited to development of new diagnostic and prognostic tools. It is well known that there is an inter relationship between the aortic valve impairment and pathologies of the aorta and coronary vessels. However, due to the limitations of the current tools, the possible link is not fully elucidated. Following our previous model of the aortic root including the coronaries, in this study, we have further developed the global aspect of the model by incorporating the anatomical structure of the thoracic aorta...
September 19, 2017: Biomechanics and Modeling in Mechanobiology
https://www.readbyqxmd.com/read/28929246/a-numerical-study-of-the-hemodynamic-effect-of-the-aortic-valve-on-coronary-flow
#2
Shaily Wald, Alex Liberzon, Idit Avrahami
During diastole, coronary perfusion depends on the pressure drop between the myocardial tissue and the coronary origin located at the aortic root. This pressure difference is influenced by the flow field near the closing valve leaflets. Clinical evidence is conclusive that patients with severe aortic stenosis (AS) suffer from diastolic dysfunction during hyperemia, but show increased coronary blood flow (CBF) during rest. Transcatheter aortic valve implantation (TAVI) was shown to decrease rest CBF along with its main purpose of improving the aortic flow and reducing the risk of heart failure...
September 19, 2017: Biomechanics and Modeling in Mechanobiology
https://www.readbyqxmd.com/read/28905122/static-and-free-vibration-analyses-of-dental-prosthesis-and-atherosclerotic-human-artery-by-refined-finite-element-models
#3
E Carrera, D Guarnera, A Pagani
Static and modal responses of representative biomechanical structures are investigated in this paper by employing higher-order theories of structures and finite element approximations. Refined models are implemented in the domain of the Carrera unified formulation (CUF), according to which low- to high-order kinematics can be postulated as arbitrary and, eventually, hierarchical expansions of the generalized displacement unknowns. By using CUF along with the principle of virtual work, the governing equations are expressed in terms of fundamental nuclei of finite element arrays...
September 13, 2017: Biomechanics and Modeling in Mechanobiology
https://www.readbyqxmd.com/read/28894984/multifidelity-cma-a-multifidelity-approach-for-efficient-personalisation-of-3d-cardiac-electromechanical-models
#4
Roch Molléro, Xavier Pennec, Hervé Delingette, Alan Garny, Nicholas Ayache, Maxime Sermesant
Personalised computational models of the heart are of increasing interest for clinical applications due to their discriminative and predictive abilities. However, the simulation of a single heartbeat with a 3D cardiac electromechanical model can be long and computationally expensive, which makes some practical applications, such as the estimation of model parameters from clinical data (the personalisation), very slow. Here we introduce an original multifidelity approach between a 3D cardiac model and a simplified "0D" version of this model, which enables to get reliable (and extremely fast) approximations of the global behaviour of the 3D model using 0D simulations...
September 11, 2017: Biomechanics and Modeling in Mechanobiology
https://www.readbyqxmd.com/read/28879626/effects-of-membrane-deformability-and-bond-formation-dissociation-rates-on-adhesion-dynamics-of-a-spherical-capsule-in-shear-flow
#5
Ziying Zhang, Jun Du, Zhengying Wei, Zhen Wang, Minghui Li
Cellular adhesion plays a critical role in biological systems and biomedical applications. Cell deformation and biophysical properties of adhesion molecules are of significance for the adhesion behavior. In the present work, dynamic adhesion of a deformable capsule to a planar substrate, in a linear shear flow, is numerically simulated to investigate the combined influence of membrane deformability (quantified by the capillary number) and bond formation/dissociation rates on the adhesion behavior. The computational model is based on the immersed boundary-lattice Boltzmann method for the capsule-fluid interaction and a probabilistic adhesion model for the capsule-substrate interaction...
September 6, 2017: Biomechanics and Modeling in Mechanobiology
https://www.readbyqxmd.com/read/28879577/models-and-tissue-mimics-for-brain-shift-simulations
#6
Antonio E Forte, Stefano Galvan, Daniele Dini
Capturing the deformation of human brain during neurosurgical operations is an extremely important task to improve the accuracy or surgical procedure and minimize permanent damage in patients. This study focuses on the development of an accurate numerical model for the prediction of brain shift during surgical procedures and employs a tissue mimic recently developed to capture the complexity of the human tissue. The phantom, made of a composite hydrogel, was designed to reproduce the dynamic mechanical behaviour of the brain tissue in a range of strain rates suitable for surgical procedures...
September 6, 2017: Biomechanics and Modeling in Mechanobiology
https://www.readbyqxmd.com/read/28861632/margination-and-adhesion-of-micro-and-nanoparticles-in-the-coronary-circulation-a-step-towards-optimised-drug-carrier-design
#7
Mohamadamin Forouzandehmehr, Amir Shamloo
Obstruction of left anterior descending artery (LAD) due to the thrombosis or atherosclerotic plaques is the leading cause of death worldwide. Targeted delivery of drugs through micro- and nanoparticles is a very promising approach for developing new strategies in clot-busting or treating restenosis. In this work, we modelled the blood flow characteristics in a patient-specific reconstructed LAD artery by the fluid-solid interaction method and based on physiological boundary conditions. Next, we provided a Lagrangian description of micro- and nanoparticles dynamics in the blood flow considering their Brownian motion and the particle-particle interactions...
August 31, 2017: Biomechanics and Modeling in Mechanobiology
https://www.readbyqxmd.com/read/28861630/an-integrated-inverse-model-experimental-approach-to-determine-soft-tissue-three-dimensional-constitutive-parameters-application-to-post-infarcted-myocardium
#8
Reza Avazmohammadi, David S Li, Thomas Leahy, Elizabeth Shih, João S Soares, Joseph H Gorman, Robert C Gorman, Michael S Sacks
Knowledge of the complete three-dimensional (3D) mechanical behavior of soft tissues is essential in understanding their pathophysiology and in developing novel therapies. Despite significant progress made in experimentation and modeling, a complete approach for the full characterization of soft tissue 3D behavior remains elusive. A major challenge is the complex architecture of soft tissues, such as myocardium, which endows them with strongly anisotropic and heterogeneous mechanical properties. Available experimental approaches for quantifying the 3D mechanical behavior of myocardium are limited to preselected planar biaxial and 3D cuboidal shear tests...
August 31, 2017: Biomechanics and Modeling in Mechanobiology
https://www.readbyqxmd.com/read/28856485/propagation-of-errors-from-skull-kinematic-measurements-to-finite-element-tissue-responses
#9
Calvin Kuo, Lyndia Wu, Wei Zhao, Michael Fanton, Songbai Ji, David B Camarillo
Real-time quantification of head impacts using wearable sensors is an appealing approach to assess concussion risk. Traditionally, sensors were evaluated for accurately measuring peak resultant skull accelerations and velocities. With growing interest in utilizing model-estimated tissue responses for injury prediction, it is important to evaluate sensor accuracy in estimating tissue response as well. Here, we quantify how sensor kinematic measurement errors can propagate into tissue response errors. Using previous instrumented mouthguard validation datasets, we found that skull kinematic measurement errors in both magnitude and direction lead to errors in tissue response magnitude and distribution...
August 30, 2017: Biomechanics and Modeling in Mechanobiology
https://www.readbyqxmd.com/read/28836010/the-potential-for-intercellular-mechanical-interaction-simulations-of-single-chondrocyte-versus-anatomically-based-distribution
#10
Jason P Halloran, Scott C Sibole, Ahmet Erdemir
Computational studies of chondrocyte mechanics, and cell mechanics in general, have typically been performed using single cell models embedded in an extracellular matrix construct. The assumption of a single cell microstructural model may not capture intercellular interactions or accurately reflect the macroscale mechanics of cartilage when higher cell concentrations are considered, as may be the case in many instances. Hence, the goal of this study was to compare cell-level response of single and eleven cell biphasic finite element models, where the latter provided an anatomically based cellular distribution representative of the actual number of cells for a commonly used [Formula: see text] edge cubic representative volume in the middle zone of cartilage...
August 24, 2017: Biomechanics and Modeling in Mechanobiology
https://www.readbyqxmd.com/read/28836078/stress-enhanced-calcium-kinetics-in-a-neuron
#11
Aayush Kant, Tanmay K Bhandakkar, Nikhil V Medhekar
Accurate modeling of the mechanobiological response of a Traumatic Brain Injury is beneficial toward its effective clinical examination, treatment and prevention. Here, we present a stress history-dependent non-spatial kinetic model to predict the microscale phenomena of secondary insults due to accumulation of excess calcium ions (Ca[Formula: see text]) induced by the macroscale primary injuries. The model is able to capture the experimentally observed increase and subsequent partial recovery of intracellular Ca[Formula: see text] concentration in response to various types of mechanical impulses...
August 23, 2017: Biomechanics and Modeling in Mechanobiology
https://www.readbyqxmd.com/read/28825147/vesicle-adhesion-reveals-novel-universal-relationships-for-biophysical-characterization
#12
Ehsan Irajizad, Ashutosh Agrawal
Adhesion plays an integral role in diverse biological functions ranging from cellular transport to tissue development. Estimation of adhesion strength, therefore, becomes important to gain biophysical insight into these phenomena. In this study, we use curvature elasticity to present non-intuitive, yet remarkably simple, universal relationships that capture vesicle-substrate interactions. These relationships not only provide efficient strategies to tease out adhesion energy of biological molecules but can also be used to characterize the physical properties of elastic biomimetic nanoparticles...
August 20, 2017: Biomechanics and Modeling in Mechanobiology
https://www.readbyqxmd.com/read/28823079/mechanobiological-model-of-arterial-growth-and-remodeling
#13
Maziyar Keshavarzian, Clark A Meyer, Heather N Hayenga
A coupled agent-based model (ABM) and finite element analysis (FEA) computational framework is developed to study the interplay of bio-chemo-mechanical factors in blood vessels and their role in maintaining homeostasis. The agent-based model implements the power of REPAST Simphony libraries and adapts its environment for biological simulations. Coupling a continuum-level model (FEA) to a cellular-level model (ABM) has enabled this computational framework to capture the response of blood vessels to increased or decreased levels of growth factors, proteases and other signaling molecules (on the micro scale) as well as altered blood pressure...
August 19, 2017: Biomechanics and Modeling in Mechanobiology
https://www.readbyqxmd.com/read/28821971/multiscale-mechanics-of-the-cervical-facet-capsular-ligament-with-particular-emphasis-on-anomalous-fiber-realignment-prior-to-tissue-failure
#14
Sijia Zhang, Vahhab Zarei, Beth A Winkelstein, Victor H Barocas
The facet capsular ligaments encapsulate the bilateral spinal facet joints and are common sources of painful injury due to afferent innervation. These ligaments exhibit architectural complexity, which is suspected to contribute to the experimentally observed lack of co-localization between macroscopic strain and microstructural tissue damage. The heterogeneous and multiscale nature of this ligament, combined with challenges in experimentally measuring its microscale mechanics, hinders the ability to understand sensory mechanisms under normal or injurious loading...
August 18, 2017: Biomechanics and Modeling in Mechanobiology
https://www.readbyqxmd.com/read/28819758/an-in-silico-biomechanical-analysis-of-the-stent-esophagus-interaction
#15
Mathias Peirlinck, Nic Debusschere, Francesco Iannaccone, Peter D Siersema, Benedict Verhegghe, Patrick Segers, Matthieu De Beule
Despite all technological innovations in esophageal stent design over the past 20 years, the association between the stent design's mechanical behavior and its effect on the clinical outcome has not yet been thoroughly explored. A parametric numerical model of a commercially available esophageal bioresorbable polymeric braided wire stent is set up, accounting for stent design aspects such as braiding angle, strut material, wire thickness, degradation and friction between the wires comprising a predictive tool on the device's mechanical behavior...
August 17, 2017: Biomechanics and Modeling in Mechanobiology
https://www.readbyqxmd.com/read/28819695/theoretical-modeling-of-mechanical-homeostasis-of-a-mammalian-cell-under-gravity-directed-vector
#16
Lüwen Zhou, Chen Zhang, Fan Zhang, Shouqin Lü, Shujin Sun, Dongyuan Lü, Mian Long
Translocation of dense nucleus along gravity vector initiates mechanical remodeling of a eukaryotic cell. In our previous experiments, we quantified the impact of gravity vector on cell remodeling by placing an MC3T3-E1 cell onto upward (U)-, downward (D)-, or edge-on (E)- orientated substrate. Our experimental data demonstrate that orientation dependence of nucleus longitudinal translocation is positively correlated with cytoskeletal (CSK) remodeling of their expressions and structures and also is associated with rearrangement of focal adhesion complex (FAC)...
August 17, 2017: Biomechanics and Modeling in Mechanobiology
https://www.readbyqxmd.com/read/28815378/effect-of-aging-on-mechanical-stresses-deformations-and-hemodynamics-in-human-femoropopliteal-artery-due-to-limb-flexion
#17
Anastasia Desyatova, Jason MacTaggart, Rodrigo Romarowski, William Poulson, Michele Conti, Alexey Kamenskiy
Femoropopliteal artery (FPA) reconstructions are notorious for poor clinical outcomes. Mechanical and flow conditions that occur in the FPA with limb flexion are thought to play a significant role, but are poorly characterized. FPA deformations due to acute limb flexion were quantified using a human cadaver model and used to build a finite element model that simulated surrounding tissue forces associated with limb flexion-induced deformations. Strains and intramural principal mechanical stresses were determined for seven age groups...
August 16, 2017: Biomechanics and Modeling in Mechanobiology
https://www.readbyqxmd.com/read/28808796/structural-alteration-of-the-endothelial-glycocalyx-contribution-of-the-actin-cytoskeleton
#18
Weiqi Li, Wen Wang
The endothelial glycocalyx is a carbohydrate-protein layer that lines the luminal surface of the endothelium. It anchors to the cell membrane via its core proteins that share extended link to the actin cytoskeleton. It is widely accepted that those protein domains and the attached carbohydrates are susceptible to pathological changes. It is unclear, however, to what extent the actin cytoskeleton contributes to the glycocalyx stability. In this study, we investigate the role of the actin cytoskeleton in the maintenance of the glycocalyx under static and laminar flow conditions in vitro...
August 14, 2017: Biomechanics and Modeling in Mechanobiology
https://www.readbyqxmd.com/read/28795282/microscale-poroelastic-metamodel-for-efficient-mesoscale-bone-remodelling-simulations
#19
C C Villette, A T M Phillips
Bone functional tissue adaptation is a multiaspect physiological process driven by interrelated mechanical and biological stimuli which requires the combined activity of osteoclasts and osteoblasts. In previous work, the authors developed a phenomenological mesoscale structural modelling approach capable of predicting internal structure of the femur based on daily activity loading, which relied on the iterative update of the cross-sectional areas of truss and shell elements representative of trabecular and cortical bones, respectively...
August 9, 2017: Biomechanics and Modeling in Mechanobiology
https://www.readbyqxmd.com/read/28785830/peristaltic-biofluids-flow-through-vertical-porous-human-vessels-using-third-grade-non-newtonian-fluids-model
#20
Pooria Akbarzadeh
In this paper, the heat and flow characteristic of third-grade non-Newtonian biofluids flow through a vertical porous human vessel due to peristaltic wall motion are studied. The third-grade model can describe shear thinning (or shear thickening) and normal stress differences, which is acceptable for biofluids modeling. In order to solve the governing equations, the assumption of long-wavelength approximation is utilized. This hypothesis emphasizes that the wavelength of the peristaltic wall motion is large in comparison with the radius of the human vessel, which is widely acceptable in biological investigations...
August 7, 2017: Biomechanics and Modeling in Mechanobiology
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