Cristiana Pereira Malta, Elize Aparecida Santos Musachio, Eliana Jardim Fernandes, Elizabeth Sabryna Sarquis Escalante, Fernanda Vilhalba Benites, Marina Prigol, Raquel Cristine Silva Barcelos, Renata Dornelles Morgental, Hecson Jesser Segat
The aim of this work was to evaluate the toxicological action of AH Plus (AHP), Bio-C Sealer (BCS), and EndoSequence BC Sealer (ESB), using Drosophila melanogaster as the model organism performing in vivo and ex vivo analysis. D. melanogaster were exposed for 10 days to three concentrations (5 mg/ml, 10 mg/ml, and 20 mg/ml) of AHP, BCS, and ESB sealers mixed with 10 ml of standard diet. During this period, the mortality of flies was evaluated. On the 11th day, the locomotor activity test was performed and the flies were euthanized for oxidative damage analysis (reactive species and lipid peroxidation) and cell viability (resazurin reduction)...
March 17, 2024: Odontology