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Aging Clinical and Experimental Research

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https://www.readbyqxmd.com/read/28702899/complex-antioxidants-in-a-randomized-single-blinded-study-of-memory-in-seniors
#1
William K Summers, Roy L Martin, Yimeng Liu, Bernice Peña, Gary M Marsh
INTRODUCTION: Oxidative injury to the brain and aging are theoretical co-causes of Alzheimer's Disease (AD). Amyloid plaques and tangles are then secondary phenomenon. The preclinical state would then be 'normal' elderly. METHODS: A potent complex antioxidant (antiOx) was tested against a popular one-a-day multivitamin (mV) in a randomized single blind design in 'normal' senior subjects over 6 months. Memory testing was done at baseline, 1, 3, and 6 months. The generalized estimating equation (GEE) approach was used to compare the change score of NLT100 and 20WR between two groups over time...
July 12, 2017: Aging Clinical and Experimental Research
https://www.readbyqxmd.com/read/28699000/nature-diversity-and-well-being-in-old-age
#2
Merja Rantakokko, Kirsi E Keskinen, Katja Kokko, Erja Portegijs
BACKGROUND: The research aim was to study the associations of nature diversity with quality of life (QoL) and depressive symptoms among older people, and whether physical activity explains the associations. METHODS: Community-dwelling people aged 75-90 years (n = 848) living in Central Finland were interviewed in their homes. QoL was assessed with a short version of the World Health Organization Quality-of-Life Assessment (range 0-130, higher score indicates better QoL) and depressive symptoms with the Centre for Epidemiologic Studies Depression Scale (range 0-30, higher scores indicate more depressive symptoms)...
July 11, 2017: Aging Clinical and Experimental Research
https://www.readbyqxmd.com/read/28688080/the-italian-version-of-the-frailty-index-based-on-deficits-in-health-a-validation-study
#3
Pasquale Abete, Claudia Basile, Giulia Bulli, Francesco Curcio, Ilaria Liguori, David Della-Morte, Gaetano Gargiulo, Assunta Langellotto, Gianluca Testa, Gianluigi Galizia, Domenico Bonaduce, Francesco Cacciatore
BACKGROUND AND AIM: Several measurements were taken for frailty classification in geriatric population. "Frailty index" is based on "deficits in health," but it is still not available in Italian version. Thus, the aim of the present work was to validate a version of "frailty index" for the Italian geriatric community. METHODS: The validation of Italian frailty index (IFi) is based on a cohort study that enrolled 1077 non-disabled outpatients aged 65 years or older (81...
July 7, 2017: Aging Clinical and Experimental Research
https://www.readbyqxmd.com/read/28688079/self-perceived-care-needs-in-older-adults-with-joint-pain-and-comorbidity
#4
Lotte A H Hermsen, Emiel O Hoogendijk, Johannes C van der Wouden, Martin Smalbrugge, Stephanie S Leone, Henriëtte E van der Horst, Joost Dekker
BACKGROUND: The aim of this study was to explore self-perceived care needs and determinants of identified needs in older adults with joint pain and comorbidity. METHODS: This is a cross-sectional study using baseline data from a cohort study of older adults in the Netherlands (≥65 years) with joint pain and comorbidity (n = 407). We used the Camberwell Assessment of Need for the Elderly (CANE) to assess self-perceived care needs. Regression analyses were conducted to examine the associations between needs and sociodemographic factors (age, gender, partner status and educational level), physical factors (pain intensity, comorbidity, frailty and physical functioning) and psychosocial factors (anxiety, depression and social support)...
July 7, 2017: Aging Clinical and Experimental Research
https://www.readbyqxmd.com/read/28681134/effect-of-body-mass-index-and-fat-mass-on-balance-force-platform-measurements-during-a-one-legged-stance-in-older-adults
#5
Camila Pereira, Rubens A da Silva, Marcio R de Oliveira, Rejane D N Souza, Renata J Borges, Edgar R Vieira
The purpose of this study was to evaluate the impact of body mass index (BMI) and fat mass on balance force platform measurements in older adults. The sample consisted of 257 participants who were stratified into four groups by BMI: low weight, normal weight, pre-obesity and obesity. For fat mass variables, older individuals were classified into low and high-fat mass. All groups investigated performed three trials of one-legged stance balance on a force platform. Center of pressure (COP) domain parameters were computed from the mean across trials...
July 5, 2017: Aging Clinical and Experimental Research
https://www.readbyqxmd.com/read/28664458/quality-of-life-assessment-in-musculo-skeletal-health
#6
REVIEW
Charlotte Beaudart, Emmanuel Biver, Olivier Bruyère, Cyrus Cooper, Nasser Al-Daghri, Jean-Yves Reginster, René Rizzoli
Musculoskeletal disorders affect morbidity, quality of life and mortality, and represent an increasing economic and societal burden in the context of population aging and increased life expectancy. Improvement of quality of life should be one of the priorities of any interventions to prevent and treat musculoskeletal disorders in the ageing population. Two main approaches, namely generic and disease-specific instruments, can be applied to measure health-related quality of life. Among the generic tools available in scientific literature, the short form 36 questionnaire (SF-36) and the Euroqol five item questionnaire (EQ-5D) are two of the most popular questionnaires used to quantify the health related quality of life in people with musculoskeletal disorders...
June 29, 2017: Aging Clinical and Experimental Research
https://www.readbyqxmd.com/read/28664457/hematological-parameters-and-all-cause-mortality-a-prospective-study-of-older-people
#7
Joanna Frąckiewicz, Dariusz Włodarek, Anna Brzozowska, Elżbieta Wierzbicka, Małgorzata Anna Słowińska, Lidia Wądołowska, Joanna Kałuża
BACKGROUND: The effect of low and high concentration of some hematological parameters in the blood can have a negative impact on health. AIM: Therefore, we investigated the associations between hematological parameters and all-cause mortality among older people living in Poland. METHODS: The study was carried out among 75-80-year-old participants (n = 403) from Warsaw and Olsztyn regions, Poland. Information on lifestyle factors and food consumption were obtained at baseline (June 1, 1999) using a self-administered questionnaire...
June 29, 2017: Aging Clinical and Experimental Research
https://www.readbyqxmd.com/read/28660596/risk-factors-for-mortality-in-elderly-patients-with-hip-fractures-a-meta-analysis-of-18-studies
#8
Yan Liu, Zhiqian Wang, Wenliang Xiao
BACKGROUND: Hip fracture is common and associated with poor outcomes in elderly patients. This meta-analysis aims to investigate the risk factors that might increase the mortality rate in elderly patients with hip fracture. METHODS: PubMed, Embase, and Web of Science were systematically searched for observational studies regarding the prognostic factors of mortality in elderly patients with hip fracture. A fixed-effects or random-effects model was used to calculate pooled hazard ratio (HR) and 95% confidence intervals (95% CIs)...
June 28, 2017: Aging Clinical and Experimental Research
https://www.readbyqxmd.com/read/28660595/mismatch-between-stiffness-in-elastic-and-muscular-arteries-as-a-predictor-of-vascular-calcification-in-dialysis-patients
#9
Agne Laucyte-Cibulskiene, Modesta Petraviciute, Migle Gudynaite, Liutauras Gumbys, Dileta Valanciene, Kristina Galiauskiene, Ligita Ryliskyte, Laurynas Rimsevicius, Marius Miglinas, Kestutis Strupas
BACKGROUND: Vascular calcification is one of the risk factors for arterial stiffness in patients with chronic kidney disease. We hypothesized that a mismatch between elastic and muscular arteries, represented as pulse wave velocity (PWV) ratio, could depict the extent of vascular calcification in end-stage renal disease. We also aimed to compare the predictive PWV ratio value to other factors possibly related to vascular calcification in dialysis population. METHODS: In this cross-sectional study, in 60 chronic dialysis patients without previous cerebrovascular events, cardiovascular disease and events or clinically evident peripheral artery disease (ankle-brachial index >0...
June 28, 2017: Aging Clinical and Experimental Research
https://www.readbyqxmd.com/read/28660594/thalidomide-combined-with-chemotherapy-in-treating-elderly-patients-with-advanced-gastric-cancer
#10
Ya Li, Yanjun Chu, Ruifeng Song, Feng Xu
AIM: The current systemic chemotherapy brings toxicity to human body, which elder patients suffer more than young people. The effective and well-tolerated treatment methods are of great importance for elderly advanced GC patients. This paper proposed an effective way of combining thalidomide with chemotherapy to treat elderly advanced GC patients, on the purpose of improving life quality and the treatment efficacy. METHODS: In the control group, capecitabine was given with 2000 mg/m(2) daily in a manner of 2 weeks on and 1 week off for elderly advanced GC patients...
June 28, 2017: Aging Clinical and Experimental Research
https://www.readbyqxmd.com/read/28653254/prognostic-value-of-short-term-decline-of-forced-expiratory-volume-in-1%C3%A2-s-over-height-cubed-fev1-ht-3-in-a-cohort-of-adults-aged-80-and-over
#11
Eralda Hegendörfer, Bert Vaes, Catharina Matheï, Gijs Van Pottelbergh, Jean-Marie Degryse
BACKGROUND: Forced expiratory volume in 1 s over height cubed (FEV1/Ht(3)) is an FEV1 expression that uses no reference values and is independently associated with adverse outcomes in older adults. No studies have reported on the prognostic value of its decline over time in adults aged 80 and over. AIM: To investigate the prognostic value of FEV1/Ht(3) decline for adverse outcomes in a cohort of adults aged 80 and over. METHODS: 328 community-dwelling adults aged 80 and over of the BELFRAIL prospective cohort had two valid FEV1 measurements as part of their comprehensive geriatric assessment at baseline and follow-up (after 1...
June 26, 2017: Aging Clinical and Experimental Research
https://www.readbyqxmd.com/read/28646250/assessing-competence-at-a-higher-level-among-older-adults-development-of-the-japan-science-and-technology-agency-index-of-competence-jst-ic
#12
Hajime Iwasa, Yukie Masui, Hiroki Inagaki, Yuko Yoshida, Hiroyuki Shimada, Rika Otsuka, Kazunori Kikuchi, Kumiko Nonaka, Hiroto Yoshida, Hideyo Yoshida, Takao Suzuki
BACKGROUND AND AIMS: Older adults' ever-improving health and changing lifestyles necessitate the development of a scale that can better measure their competence at a higher level. We developed the Japan Science and Technology Agency Index of Competence (JST-IC) via item analysis and assessed its psychometric properties. METHODS: Participants were 1306 community-dwelling older adults (623 men and 683 women, 74.0 ± 2.8 years old) who completed the 54-item draft JST-IC to determine their level of independence...
June 23, 2017: Aging Clinical and Experimental Research
https://www.readbyqxmd.com/read/28616854/ventricular-arterial-coupling-in-centenarians-without-cardiovascular-diseases
#13
Andrea Sonaglioni, Massimo Baravelli, Michele Lombardo, Carmen Sommese, Claudio Anzà, Jonathan A Kirk, Luigi Padeletti
BACKGROUND: Ventricular-arterial (VA) coupling is a central determinant of cardiovascular system performance and cardiac energetics. This index is expressed by the Ea/Ees ratio, where the effective arterial elastance (Ea) indicates the net arterial load exerted on the left ventricle and the left ventricular end-systolic elastance (Ees) is a load-independent measure of left ventricular chamber performance. METHODS: Thirty-three centenarians (100.6 ± 1.2 years, range 99-105 years, 10 M) without cardiovascular diseases underwent a complete echocardiographic evaluation and an instantaneous arterial blood pressure measurement, to characterize the Ea/Ees ratio and its two determinants indexed to body surface area...
June 14, 2017: Aging Clinical and Experimental Research
https://www.readbyqxmd.com/read/28608256/development-and-examination-of-a-functional-reactive-agility-test-for-older-adults
#14
Eric J Sobolewski, Brennan J Thompson, Eric C Conchola, Eric D Ryan
BACKGROUND: Reactive agility tests have become popular in sport for talent identification; however, the ability of these tests to evaluate physical function and falls risk in clinical populations warrants future study. AIM: To examine the reliability and construct validity of a novel functional reactive agility test (FRAT) across the lifespan. METHODS: Forty-three young (24 ± 2 years), 32 middle-aged (50 ± 2 years), and 19 old (66 ± 4 years) men performed a FRAT that included a rapid lateral movement (1...
June 12, 2017: Aging Clinical and Experimental Research
https://www.readbyqxmd.com/read/28608255/temporal-trends-in-herpes-zoster-related-hospitalizations-in-italy-2001-2013-differences-between-regions-that-have-or-have-not-implemented-varicella-vaccination
#15
Nicoletta Valente, Silvia Cocchio, Armando Stefanati, Tatjana Baldovin, Domenico Martinelli, Rosa Prato, Vincenzo Baldo, Giovanni Gabutti
BACKGROUND: Herpes zoster (HZ) has a relevant impact on the population in terms of incidence and complications. AIMS: The aim of this study was to estimate the HZ-related hospitalization rates in Italy in the period 2001-2013, and to evaluate the trend of hospitalizations in the course of time pointing out any differences between regions that have or have not introduced universal childhood varicella immunization (UVI). METHODS: A retrospective analysis was conducted on hospital discharge records contained in the national database of the Ministry of Health for the period January 2001-December 2013...
June 12, 2017: Aging Clinical and Experimental Research
https://www.readbyqxmd.com/read/28608254/determinants-of-physical-functioning-in-women-with-knee-osteoarthritis
#16
Hakan Nur, Bilge Saruhan Sertkaya, Tiraje Tuncer
BACKGROUND: Knee osteoarthritis (OA) is an important health problem with its high prevalence and association with pain and functional disability in physical tasks and activities especially in women. AIMS: To explore the impacts of widely seen demographic, pathological, psychological, and impairment factors on physical functioning in women with knee OA using the performance-based and self-reported measures. METHODS: One hundred and ten women with knee OA participated in this study...
June 12, 2017: Aging Clinical and Experimental Research
https://www.readbyqxmd.com/read/28593468/association-of-the-il6-rs1800796-but-not-of-the-il6-rs1800795-il6r-rs4845617-and-rs2228145-polymorphisms-with-hip-fracture-in-elderly-mexican-women
#17
Valeria Ponce de León-Suárez, Margarita Valdés-Flores, Antonio Miranda-Duarte, Esperanza Ramírez-Pérez, Alin Pérez-Ríos, Blanca Barredo-Prieto, Alberto Hidalgo-Bravo, Leonora Casas-Avila
BACKGROUND AND AIMS: Polymorphisms in Interleukin-6 (IL6) and its receptor (IL6R) have been associated with bone mineral density. In this work, the G-174C and G-572C polymorphisms in IL6, G-208A, and Asp358Ala in IL6R were analyzed in Mexican women with hip fracture. METHODS: Postmenopausal Mexican women (60 years or over) with hip fragility fracture (77.97 ± 8 years) and without hip fracture (70.5 ± 7.02 years) were genotyped by real-time PCR. RESULTS: The rs1800796 GG genotype was associated with low risk of fracture (p = 0...
June 7, 2017: Aging Clinical and Experimental Research
https://www.readbyqxmd.com/read/28584901/endovascular-treatment-of-diabetic-peripheral-arterial-disease-in-older-and-oldest-old-patients-a-retrospective-study
#18
Cristina Gatti, Sara Cecchini, Paolo Fabbietti, Fabio Romagnoli, Stefano Ricci
BACKGROUND: Peripheral arterial disease (PAD) is frequent among older diabetic patients, but the evidence about endovascular revascularization is very limited. METHOD: We retrospectively analyzed data collected from 120 diabetic patients consecutively admitted to a Diabetic Foot Clinic, including 64 patients aged 65-79 years and 56 patients aged 80 or more. RESULTS: Percutaneous transluminal angioplasty (PTA) was followed by technical success in 82...
June 3, 2017: Aging Clinical and Experimental Research
https://www.readbyqxmd.com/read/28577161/morphological-and-qualitative-characteristics-of-the-quadriceps-muscle-of-community-dwelling-older-adults-based-on-ultrasound-imaging-classification-using-latent-class-analysis
#19
Hisashi Kawai, Takeshi Kera, Ryo Hirayama, Hirohiko Hirano, Yoshinori Fujiwara, Kazushige Ihara, Motonaga Kojima, Shuichi Obuchi
BACKGROUND: Muscle thickness and echo intensity measured using ultrasound imaging represent both increased muscle volume and connective tissue accumulation. In combination, these ultrasound measurements can be utilized for assessing sarcopenia in community-dwelling older adults. AIMS: This study aimed to determine whether morphological and qualitative characteristics classified by quadriceps muscle thickness and echo intensity measured using ultrasound are associated with muscle strength, physical function, and sarcopenia in community-dwelling older adults...
June 2, 2017: Aging Clinical and Experimental Research
https://www.readbyqxmd.com/read/28560545/relationships-among-peak-expiratory-flow-rate-body-composition-physical-function-and-sarcopenia-in-community-dwelling-older-adults
#20
Takeshi Kera, Hisashi Kawai, Hirohiko Hirano, Motonaga Kojima, Yoshinori Fujiwara, Kazushige Ihara, Shuichi Obuchi
BACKGROUND AND AIM: Although respiratory muscle strength is known to decrease with age, the relationship between pulmonary function and sarcopenia remains to be examined. The present study aimed to determine the relationship between peak expiratory flow rate (PEFR) and skeletal muscle mass/sarcopenia in community-dwelling older adults. METHODS: We utilized data from 427 older adults (age 74.4 ± 5.3 years, men/women 157/270) who had participated in the 2015 Otassha Kenshin, a longitudinal study that excluded participants with air-flow limitations...
May 30, 2017: Aging Clinical and Experimental Research
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