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Aging Clinical and Experimental Research

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https://www.readbyqxmd.com/read/28616854/ventricular-arterial-coupling-in-centenarians-without-cardiovascular-diseases
#1
Andrea Sonaglioni, Massimo Baravelli, Michele Lombardo, Carmen Sommese, Claudio Anzà, Jonathan A Kirk, Luigi Padeletti
BACKGROUND: Ventricular-arterial (VA) coupling is a central determinant of cardiovascular system performance and cardiac energetics. This index is expressed by the Ea/Ees ratio, where the effective arterial elastance (Ea) indicates the net arterial load exerted on the left ventricle and the left ventricular end-systolic elastance (Ees) is a load-independent measure of left ventricular chamber performance. METHODS: Thirty-three centenarians (100.6 ± 1.2 years, range 99-105 years, 10 M) without cardiovascular diseases underwent a complete echocardiographic evaluation and an instantaneous arterial blood pressure measurement, to characterize the Ea/Ees ratio and its two determinants indexed to body surface area...
June 14, 2017: Aging Clinical and Experimental Research
https://www.readbyqxmd.com/read/28608256/development-and-examination-of-a-functional-reactive-agility-test-for-older-adults
#2
Eric J Sobolewski, Brennan J Thompson, Eric C Conchola, Eric D Ryan
BACKGROUND: Reactive agility tests have become popular in sport for talent identification; however, the ability of these tests to evaluate physical function and falls risk in clinical populations warrants future study. AIM: To examine the reliability and construct validity of a novel functional reactive agility test (FRAT) across the lifespan. METHODS: Forty-three young (24 ± 2 years), 32 middle-aged (50 ± 2 years), and 19 old (66 ± 4 years) men performed a FRAT that included a rapid lateral movement (1...
June 12, 2017: Aging Clinical and Experimental Research
https://www.readbyqxmd.com/read/28608255/temporal-trends-in-herpes-zoster-related-hospitalizations-in-italy-2001-2013-differences-between-regions-that-have-or-have-not-implemented-varicella-vaccination
#3
Nicoletta Valente, Silvia Cocchio, Armando Stefanati, Tatjana Baldovin, Domenico Martinelli, Rosa Prato, Vincenzo Baldo, Giovanni Gabutti
BACKGROUND: Herpes zoster (HZ) has a relevant impact on the population in terms of incidence and complications. AIMS: The aim of this study was to estimate the HZ-related hospitalization rates in Italy in the period 2001-2013, and to evaluate the trend of hospitalizations in the course of time pointing out any differences between regions that have or have not introduced universal childhood varicella immunization (UVI). METHODS: A retrospective analysis was conducted on hospital discharge records contained in the national database of the Ministry of Health for the period January 2001-December 2013...
June 12, 2017: Aging Clinical and Experimental Research
https://www.readbyqxmd.com/read/28608254/determinants-of-physical-functioning-in-women-with-knee-osteoarthritis
#4
Hakan Nur, Bilge Saruhan Sertkaya, Tiraje Tuncer
BACKGROUND: Knee osteoarthritis (OA) is an important health problem with its high prevalence and association with pain and functional disability in physical tasks and activities especially in women. AIMS: To explore the impacts of widely seen demographic, pathological, psychological, and impairment factors on physical functioning in women with knee OA using the performance-based and self-reported measures. METHODS: One hundred and ten women with knee OA participated in this study...
June 12, 2017: Aging Clinical and Experimental Research
https://www.readbyqxmd.com/read/28593468/association-of-the-il6-rs1800796-but-not-of-the-il6-rs1800795-il6r-rs4845617-and-rs2228145-polymorphisms-with-hip-fracture-in-elderly-mexican-women
#5
Valeria Ponce de León-Suárez, Margarita Valdés-Flores, Antonio Miranda-Duarte, Esperanza Ramírez-Pérez, Alin Pérez-Ríos, Blanca Barredo-Prieto, Alberto Hidalgo-Bravo, Leonora Casas-Avila
BACKGROUND AND AIMS: Polymorphisms in Interleukin-6 (IL6) and its receptor (IL6R) have been associated with bone mineral density. In this work, the G-174C and G-572C polymorphisms in IL6, G-208A, and Asp358Ala in IL6R were analyzed in Mexican women with hip fracture. METHODS: Postmenopausal Mexican women (60 years or over) with hip fragility fracture (77.97 ± 8 years) and without hip fracture (70.5 ± 7.02 years) were genotyped by real-time PCR. RESULTS: The rs1800796 GG genotype was associated with low risk of fracture (p = 0...
June 7, 2017: Aging Clinical and Experimental Research
https://www.readbyqxmd.com/read/28584901/endovascular-treatment-of-diabetic-peripheral-arterial-disease-in-older-and-oldest-old-patients-a-retrospective-study
#6
Cristina Gatti, Sara Cecchini, Paolo Fabbietti, Fabio Romagnoli, Stefano Ricci
BACKGROUND: Peripheral arterial disease (PAD) is frequent among older diabetic patients, but the evidence about endovascular revascularization is very limited. METHOD: We retrospectively analyzed data collected from 120 diabetic patients consecutively admitted to a Diabetic Foot Clinic, including 64 patients aged 65-79 years and 56 patients aged 80 or more. RESULTS: Percutaneous transluminal angioplasty (PTA) was followed by technical success in 82...
June 3, 2017: Aging Clinical and Experimental Research
https://www.readbyqxmd.com/read/28577161/morphological-and-qualitative-characteristics-of-the-quadriceps-muscle-of-community-dwelling-older-adults-based-on-ultrasound-imaging-classification-using-latent-class-analysis
#7
Hisashi Kawai, Takeshi Kera, Ryo Hirayama, Hirohiko Hirano, Yoshinori Fujiwara, Kazushige Ihara, Motonaga Kojima, Shuichi Obuchi
BACKGROUND: Muscle thickness and echo intensity measured using ultrasound imaging represent both increased muscle volume and connective tissue accumulation. In combination, these ultrasound measurements can be utilized for assessing sarcopenia in community-dwelling older adults. AIMS: This study aimed to determine whether morphological and qualitative characteristics classified by quadriceps muscle thickness and echo intensity measured using ultrasound are associated with muscle strength, physical function, and sarcopenia in community-dwelling older adults...
June 2, 2017: Aging Clinical and Experimental Research
https://www.readbyqxmd.com/read/28560545/relationships-among-peak-expiratory-flow-rate-body-composition-physical-function-and-sarcopenia-in-community-dwelling-older-adults
#8
Takeshi Kera, Hisashi Kawai, Hirohiko Hirano, Motonaga Kojima, Yoshinori Fujiwara, Kazushige Ihara, Shuichi Obuchi
BACKGROUND AND AIM: Although respiratory muscle strength is known to decrease with age, the relationship between pulmonary function and sarcopenia remains to be examined. The present study aimed to determine the relationship between peak expiratory flow rate (PEFR) and skeletal muscle mass/sarcopenia in community-dwelling older adults. METHODS: We utilized data from 427 older adults (age 74.4 ± 5.3 years, men/women 157/270) who had participated in the 2015 Otassha Kenshin, a longitudinal study that excluded participants with air-flow limitations...
May 30, 2017: Aging Clinical and Experimental Research
https://www.readbyqxmd.com/read/28560544/profile-of-osteoarthritic-patients-undergoing-hip-or-knee-arthroplasty-a-step-toward-a-definition-of-the-need-for-surgery
#9
Audrey Neuprez, Arnaud H Neuprez, William Kurth, Philippe Gillet, Olivier Bruyère, Jean-Yves Reginster
AIMS: The objective of this study is to characterize, based on clinical, radiographic, health-related, quality-of-life-related, and demographic variables, the profile of a large, homogeneous, cohort of patients undergoing knee or hip arthroplasty, in a public hospital. Current regulatory guidelines for structure-modifying agent are not clear regarding hard clinical endpoint. The "need for surgery" has been suggested as a potential relevant outcome, but, until now, it is poorly defined...
May 30, 2017: Aging Clinical and Experimental Research
https://www.readbyqxmd.com/read/28550397/nutritional-status-physical-performance-and-disability-in-the-elderly-of-the-peruvian-andes-reply-to-ortiz
#10
LETTER
Nicola Veronese, Alessandra Tramontano
No abstract text is available yet for this article.
May 26, 2017: Aging Clinical and Experimental Research
https://www.readbyqxmd.com/read/28534302/overlooked-dysphagia-a-life-threatening-condition
#11
Giorgio Maiuri, Andrea Corsonello, Fortunato Monteleone, Annamaria Nicoletti, Flavio Fedele, Giuseppina Marrazzo, Vittorio Sapiente, Pietro Vivona, Bruno Mazzei
No abstract text is available yet for this article.
May 22, 2017: Aging Clinical and Experimental Research
https://www.readbyqxmd.com/read/28534301/effects-of-acetyl-l-carnitine-in-diabetic-neuropathy-and-other-geriatric-disorders
#12
REVIEW
G Sergi, S Pizzato, F Piovesan, C Trevisan, N Veronese, E Manzato
A long history of diabetes mellitus and increasing age are associated with the onset of diabetic neuropathy, a painful and highly disabling complication with a prevalence peaking at 50% among elderly diabetic patients. Acetyl-L-carnitine (ALC) is a molecule derived from the acetylation of carnitine in the mitochondria that has an essential role in energy production. It has recently been proposed as a therapy to improve the symptoms of diabetic neuropathy. ALC is widely distributed in mammalian tissues, including the brain, blood-brain barrier, brain neurons, and astrocytes...
May 22, 2017: Aging Clinical and Experimental Research
https://www.readbyqxmd.com/read/28527135/association-between-muscle-function-cognitive-state-depression-symptoms-and-quality-of-life-of-older-people-evidence-from-clinical-practice
#13
Salah Gariballa, Awad Alessa
BACKGROUND: Although low muscle function/strength is an important predictor of poor clinical outcome in older patients, information on its impact on mental health in clinical practice is still lacking. AIMS: The aim of this report is to measure the impact of low muscle function measured by handgrip strength on mental health of older people during both acute illness and recovery. METHODS: Four hundred and thirty-two randomly selected hospitalized older patients had their baseline demographic and clinical characteristics assessed within 72 h of admission, at 6 weeks and at 6 months...
May 19, 2017: Aging Clinical and Experimental Research
https://www.readbyqxmd.com/read/28527134/comparison-of-nurses-and-general-caregivers-knowledge-attitude-and-practice-on-medication-administration-process-and-their-distress-level-in-long-term-care-facilities-across-penang-kuala-lumpur-and-selangor-of-malaysia
#14
Balamurugan Tangiisuran, Sok Cin Tye, May Yen Leow, Rahmat Awang
AIM: Comparing nurses and general caregivers' knowledge, attitude, and practices (KAP) on medication administration process in long-term care (LTC) setting and an assessment of their stress, anxiety, and depression (SAD) level. METHODS: A cross-sectional survey was conducted among nurses and general caregivers working in LTC using a validated questionnaire. Consisting of demographic characteristics (Section 1); 40 questions on KAP (Section 2); and assessment of Depression, Anxiety, and Stress Scale (DASS-21) (Section 3)...
May 19, 2017: Aging Clinical and Experimental Research
https://www.readbyqxmd.com/read/28523610/motivators-for-alzheimer-s-disease-clinical-trial-participation
#15
Shoshana H Bardach, Sarah D Holmes, Gregory A Jicha
BACKGROUND: Alzheimer's disease (AD) research progress is impeded due to participant recruitment challenges. This study seeks to better understand, from the perspective of individuals engaged in clinical trials (CTs), research motivations. METHODS: Participants, or their caregivers, from AD treatment and prevention CTs were surveyed about research motivators. RESULTS: The 87 respondents had a mean age of 72.2, were predominantly Caucasian, 55...
May 18, 2017: Aging Clinical and Experimental Research
https://www.readbyqxmd.com/read/28523609/cardiorespiratory-responses-and-myocardial-function-within-incremental-exercise-in-healthy-unmedicated-older-vs-young-men-and-women
#16
Paulo Farinatti, Walace Monteiro, Ricardo Oliveira, Antonio Crisafulli
BACKGROUND: Age-related differences concerning cardiorespiratory responses and myocardial function during exercise have not been extensively investigated in healthy populations. AIMS: To compare cardiorespiratory performance and myocardial function during maximal exercise in healthy/unmedicated men (older, n = 24, 63-75 years; young, n = 22, 19-25 years) and women (older, n = 18, age = 63-74 years; young, n = 23, 19-25 years). METHODS: Oxygen uptake (VO2), ventilation minute (V E), heart rate (HR), stroke volume (SV), cardiac output (Q), O2 pulse (O2p), preejection period (PEP), and left ventricular ejection time (LVET) were assessed during cycle incremental exercise...
May 18, 2017: Aging Clinical and Experimental Research
https://www.readbyqxmd.com/read/28523608/excess-mortality-in-2015-a-time-series-and-cause-of-death-analysis-in-northern-italy
#17
Ugo Fedeli, Giulia Capodaglio, Elena Schievano, Eliana Ferroni, Maria Chiara Corti
AIMS: To investigate the excess mortality registered in the Veneto Region (Northern Italy) in 2015. METHODS: A Seasonal Autoregressive Integrated Moving Average Model was applied to predict overall mortality expected in 2014-2015 based on that observed in 2000-2013. The annual percent change in age-standardized rates (APC) was estimated for specific causes of death in 2007-2015. RESULTS: Compared to 2014, the number of deaths and the overall age-standardized mortality increased in 2015 by 7...
May 18, 2017: Aging Clinical and Experimental Research
https://www.readbyqxmd.com/read/28510786/the-impact-of-frailty-on-noninvasive-mechanical-ventilation-in-elderly-medical-intensive-care-unit-patients
#18
Iskender Kara, F Yildirim, A Zerman, Z Gullu, N Boyaci, B B Aydogan, U Gaygisiz, K Gonderen, G Arik, M Turkoglu, M Aydogdu, G Aygencel, Z Ulger, G Gursel
AIM: Many factors affecting noninvasive ventilation (NIV) in critically ill patients have been reported in the literature, but there is no study about the effect of frailty. With this study, the frailty prevalence was evaluated with two different frailty scores among the NIV population of a medical intensive care unit (ICU). Besides, the impact of frailty on NIV success and mortality and its association with NIV application problems were evaluated. METHOD: A prospective observational cohort study was performed on patients who were over 50 years of age and assigned to NIV due to hypercapnic respiratory failure...
May 16, 2017: Aging Clinical and Experimental Research
https://www.readbyqxmd.com/read/28510785/the-impact-of-leisure-on-mental-health-of-sardinian-elderly-from-the-blue-zone-evidence-for-ageing-well
#19
Maria Chiara Fastame, Paul Kenneth Hitchcott, Maria Pietronilla Penna
BACKGROUND: There has been scientific interest in the Sardinia population for a number of years and for a variety of reasons, including its extreme longevity. This is especially prevalent in the central-eastern region of the island, where a blue zone region has been precisely delineated. AIMS: The present study examines the influence of leisure activities on psychological well-being and depressive symptoms in elderly individuals living in the blue zone region of inner Sardinia...
May 16, 2017: Aging Clinical and Experimental Research
https://www.readbyqxmd.com/read/28474314/impact-of-caregiving-for-older-people-and-pro-inflammatory-biomarkers-among-caregivers-a-systematic-review
#20
REVIEW
Florence Potier, Jean-Marie Degryse, Marie de Saint-Hubert
INTRODUCTION: Evidence suggests that providing care for an older loved one may present a risk to the health of the caregiver. To understand the link between the psychosocial stress of caregiving and damage to the health of caregivers, numerous studies have assessed the presence of inflammatory biomarkers among caregivers. These biomarkers are measured to understand the relationships between the social stress of caregiving and the health of caregivers. OBJECTIVE: To provide a complete summary of the current literature regarding the most clinically relevant pro-inflammatory biomarkers associated with caregiving...
May 4, 2017: Aging Clinical and Experimental Research
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