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Aging Clinical and Experimental Research

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https://www.readbyqxmd.com/read/28284002/non-persistence-with-antiplatelet-therapy-in-elderly-patients-after-a-transient-ischemic-attack
#1
Martin Wawruch, Dusan Zatko, Gejza Wimmer, Jan Luha, Sona Wimmerova, Peter Kukumberg, Jan Murin, Adam Hloska, Tomas Tesar, Rashmi Shah
BACKGROUND: Antiplatelet therapy following a transient ischemic attack (TIA) constitutes an important secondary prevention measure. AIMS: The study was aimed at evaluating the development of non-persistence with antiplatelet therapy in elderly patients after a TIA and identifying patient-related characteristics associated with the probability of non-persistence during the follow-up period. METHODS: The study cohort (n = 854) was selected from the database of the largest health insurance provider of the Slovak Republic...
March 11, 2017: Aging Clinical and Experimental Research
https://www.readbyqxmd.com/read/28275956/de-educate-to-re-educate-aging-and-low-back-pain
#2
Adriaan Louw, Kory Zimney, Eldon A Johnson, Chris Kraemer, Justin Fesler, Tyler Burcham
BACKGROUND: Patients' beliefs about their condition have been shown to play a significant role in their pain experience and response to treatment, especially when a patient sees their tissue health as vulnerable or aged. Educational can alter these beliefs. Prior to new information, patients often have to be de-educated regarding common misbeliefs to undergo re-education. AIMS: To determine if a brief de-education session regarding aging and low back pain (LBP) can shift pain ratings, fear-avoidance beliefs, beliefs regarding aging and LBP, and limited active trunk flexion...
March 9, 2017: Aging Clinical and Experimental Research
https://www.readbyqxmd.com/read/28265974/elder-abuse-in-europe-s-most-elderly-city-an-assessment-of-the-phenomenon-and-an-analysis-of-the-data-from-the-penal-court-of-genoa-from-2010-to-2015
#3
Andrea Molinelli, Francesco Ventura, Sara Lo Pinto, Martina Drommi, Francesco De Stefano
INTRODUCTION: In Italy, 5% of the elderly are estimated to have suffered abuse. While the Penal Code refers to generic types of abuse, such as physical and psychological maltreatment, abandonment and financial fraud, it does not specifically protect the elderly as a category. AIMS: To assess the frequency and modalities of elder abuse in Genoa and its Province, and to compare these data with those reported in the literature, in order to provide a picture of the current situation that can be used by the authorities to combat this phenomenon...
March 6, 2017: Aging Clinical and Experimental Research
https://www.readbyqxmd.com/read/28265973/weight-change-and-risk-of-hyperglycaemia-in-elderly-women
#4
Katrine Dragsbæk, Jesper S Neergaard, Claus Christiansen, Morten A Karsdal, Henning Beck-Nielsen, Susanne Brix, Kim Henriksen
BACKGROUND: Hyperglycaemia increases the risk of type 2 diabetes, heart disease and stroke, and is influenced by weight. However, the impact of preceding weight change on blood glycemia levels in late-life is less well understood. AIM: We studied the interplay between weight change and risk of hyperglycaemia in a prospective cohort of elderly women. METHODS: Elderly Caucasian women (age: 67.1 years at baseline, n = 1173) enrolled in the Prospective Epidemiological Risk Factor study with baseline and 13-year follow-up measurements of BMI and fasting glucose levels (FPG) and no previous history of diabetes or impaired fasting glucose...
March 6, 2017: Aging Clinical and Experimental Research
https://www.readbyqxmd.com/read/28260159/emerging-biomarkers-and-screening-for-cognitive-frailty
#5
REVIEW
Qingwei Ruan, Grazia D'Onofrio, Daniele Sancarlo, Antonio Greco, Madia Lozupone, Davide Seripa, Francesco Panza, Zhuowei Yu
Physical frailty and cognitive frailty are two important targets of secondary intervention in aging research to narrow the gap between life and health span. The objective of the present narrative review was to examine clinical and epidemiological studies investigating the recently proposed construct of cognitive frailty and its subtypes, with a focus on operational definitions, clinical criteria, and emerging biomarkers potentially useful for the screening of this novel entity. Both physical frailty and frailty indexes with a multidimensional nature were associated with late-life cognitive impairment/decline, incident dementia, Alzheimer's disease (AD), mild cognitive impairment, vascular dementia, non-AD dementias, and AD pathology proposing cognitive frailty as a clinical entity with cognitive impairment related to physical causes with a potential reversibility...
March 4, 2017: Aging Clinical and Experimental Research
https://www.readbyqxmd.com/read/28258500/a-prevalence-study-of-potentially-inappropriate-medications-use-in-hospitalized-pakistani-elderly
#6
Faizan Mazhar, Shahzad Akram, Saima Mahmood Malhi, Nafis Haider
BACKGROUND: Inappropriate prescribing in elderly patients is a widespread health problem. It is associated with increased drug-related problems and health expenditure. AIMS: To determine the prevalence and types of potentially inappropriate medications (PIM) prescribed to elderly patients with polypharmacy and the factors associated with their use in these patients. METHODS: A cross-sectional study conducted among 228 elderly hospitalized patients with polypharmacy...
March 3, 2017: Aging Clinical and Experimental Research
https://www.readbyqxmd.com/read/28258499/commentary-to-the-article-nutritional-status-physical-performance-and-disability-in-the-elderly-of-the-peruvian-andes
#7
LETTER
Pedro J Ortiz, Tania Tello
No abstract text is available yet for this article.
March 3, 2017: Aging Clinical and Experimental Research
https://www.readbyqxmd.com/read/28255906/the-impact-of-frailty-on-coagulation-and-responses-to-warfarin-in-acute-older-hospitalised-patients-with-atrial-fibrillation-a-pilot-study
#8
Tu Ngoc Nguyen, Marie-Christine Morel-Kopp, Dominic Pepperell, Robert Graham Cumming, Sarah Nicole Hilmer, Christopher Morice Ward
BACKGROUND: The evidence on coagulation changes with frailty is not consistent and clinical studies suggest that frail older people may be at an increased risk of bleeding complications with anticoagulant therapy. AIMS: This study aims to assess the impact of frailty on coagulation function and on response to warfarin. METHODS: Inpatients aged over 65 years with atrial fibrillation (AF) were recruited. Frailty was determined using the Reported Edmonton Frail Scale...
March 2, 2017: Aging Clinical and Experimental Research
https://www.readbyqxmd.com/read/28251570/predictors-of-institutionalization-in-people-with-dementia-a-survey-linked-with-administrative-data
#9
Rebecca Runte
BACKGROUND: For people with dementia, moving into a nursing home is usually considered at some point in time. Currently available information on predictors of institutionalization is often based on small sample sizes, not taking competing risks into account, and with inconclusive results for sex. AIMS: We aimed to carry out an analysis stratified by sex and using a competing risk approach. METHODS: We carried out an analysis of a survey linked with administrative data including 652 people with dementia, aged 60 years and older...
March 1, 2017: Aging Clinical and Experimental Research
https://www.readbyqxmd.com/read/28251569/effects-of-feedback-based-balance-and-core-resistance-training-vs-pilates-training-on-cognitive-functions-in-older-women-with-mild-cognitive-impairment-a-pilot-randomized-controlled-trial
#10
Zrinka Greblo Jurakic, Valerija Krizanic, Nejc Sarabon, Goran Markovic
BACKGROUND: There is limited research about beneficial effects of physical activity in older adults suffering from mild cognitive impairment (MCI). AIM: The aim of the study was to provide preliminary evidence on the effects of two types of non-aerobic training on cognitive functions in older women suffering from MCI. METHODS: Twenty-eight participants aged 66-78 years with MCI were randomly assigned to a combined balance and core resistance training group (n = 14) or to a Pilates group (n = 14)...
March 1, 2017: Aging Clinical and Experimental Research
https://www.readbyqxmd.com/read/28251568/activities-of-daily-living-at-different-levels-of-renal-function-in-elderly-hospitalized-heart-failure-patients
#11
Masahiro Kitamura, Kazuhiro P Izawa, Hiroki Taniue, Yumi Mimura, Yuichi Ikeda, Hitomi Nagashima, Peter H Brubaker
BACKGROUND: Renal function (RF) and activities of daily living (ADL) are risk factors for heart failure (HF) patients. AIMS: We evaluated differences in motor and cognitive ADL in relation to RF in elderly hospitalized HF patients. METHODS: Participants were selected from 414 consecutive hospitalized HF patients based on certain criteria. We investigated patient characteristics including Functional Independence Measure (FIM) and estimated glomerular filtration rate (eGFR)...
March 1, 2017: Aging Clinical and Experimental Research
https://www.readbyqxmd.com/read/28247211/data-set-of-healthy-old-people-assessed-for-three-walking-conditions-using-accelerometric-and-opto-electronic-methods
#12
S Gillain, M Boutaayamou, N Dardenne, C Schwartz, M Demonceau, C Gerontitis, F Depierreux, E Salmon, G Garraux, O Bruyère, O Brüls, J-L Croisier, J Petermans
BACKGROUND: Gait patterns of healthy aging are needed to allow a comparison with pathological situations. However, little data is available. OBJECTIVE: To present gait pattern of healthy older specially selected to be "healthy walkers". METHOD: Fifty-seven older people benefited from a geriatric assessment including clinical and functional evaluations to include only those without gait disorders. Gait data were simultaneously recorded using a tri-axial accelerometer placed on the waist and four 3D position markers placed on the feet at the level of the heel and the toe...
February 28, 2017: Aging Clinical and Experimental Research
https://www.readbyqxmd.com/read/28247210/age-related-effects-on-maximal-and-rapid-hamstrings-quadriceps-strength-capacities-and-vertical-jump-power-in-young-and-older-females
#13
Ty B Palmer, Brittany N Followay, Brennan J Thompson
BACKGROUND AND AIMS: Declines in hamstrings and quadriceps maximal and rapid strength are commonly reported as a consequence of aging; however, few studies have investigated the influence of age on maximal and rapid hamstrings to quadriceps (H/Q) strength ratios. This study aimed to examine the effects of age on leg extension and flexion maximal and rapid torque production, H/Q strength ratios, and muscle power in healthy, young and old females. METHODS: Fifteen young (21 ± 2 years) and 15 old (69 ± 7 years) females performed 3 isometric leg extension and flexion maximal voluntary contractions (MVCs), from which peak torque (PT), early (0-30 ms) and late (0-200 ms) phase rate of torque development (RTD), and PT and RTD H/Q strength ratios were extracted...
February 28, 2017: Aging Clinical and Experimental Research
https://www.readbyqxmd.com/read/28243862/preoperative-exercise-capacity-is-associated-with-the-prevalence-of-postoperative-delirium-in-elective-cardiac-surgery
#14
Masato Ogawa, Kazuhiro P Izawa, Seimi Satomi-Kobayashi, Aki Kitamura, Yasunori Tsuboi, Kodai Komaki, Rei Ono, Yoshitada Sakai, Hiroshi Tanaka, Yutaka Okita
BACKGROUND: Postoperative delirium (POD) is a critical complication that is closely associated with mortality and major morbidity in elective cardiac surgery. The identification of patients at risk for POD is crucial but has not been fully explored. AIMS: The aim of this study was to determine the predictive value of the assessment of preoperative exercise capacity for POD. METHODS: We enrolled 313 consecutive patients (mean age, 68.6 ± 14...
February 28, 2017: Aging Clinical and Experimental Research
https://www.readbyqxmd.com/read/28238154/the-gestio-protocol-experience-safety-of-a-standardized-order-set-for-subcutaneous-insulin-regimen-in-elderly-hospitalized-patients
#15
Alessandro Franchin, Alberto Maran, Daniela Bruttomesso, Maria L Corradin, Francesco Rossi, Federica Zanatta, Gian-Maria Barbato, Nicola Sicolo, Enzo Manzato
BACKGROUNDS: In non-critical hospitalized patients with diabetes mellitus, guidelines suggest subcutaneous insulin therapy with basal-bolus regimen, even in old and vulnerable inpatients. AIM: To evaluate safety, efficacy, and benefit on clinical management of the GesTIO protocol, a set of subcutaneous insulin administration rules, in old and vulnerable non-ICU inpatients. METHODS: Retrospective, observational study. Patients admitted to Geriatric Clinic of Padua were studied...
February 25, 2017: Aging Clinical and Experimental Research
https://www.readbyqxmd.com/read/28238153/the-role-of-thigh-muscular-efforts-in-limiting-sit-to-stand-capacity-in-healthy-young-and-older-adults
#16
Megan Bryanton, Martin Bilodeau
Aging is associated with an unavoidable decline in muscle mass, known as sarcopenia, leading to neuromuscular declines, muscle weakness, and subsequent disability. One particular measure utilized by rehabilitative professionals in evaluating functional declines in older persons is sit-to-stand (STS) capacity. The purpose of this investigation was to determine the role of activation intensity requirements of the thigh musculature in limiting a multi-joint STS endurance task. To do so, surface EMG signals of the quadriceps femoris (QF) and hamstrings (biceps femoris; BF) and their co-activation ratios (H:Q) were collected in young (18-35 years; n = 12) and older (60-75 years; n = 12) adult participants who repeatedly stood from a seated position until exhaustion...
February 25, 2017: Aging Clinical and Experimental Research
https://www.readbyqxmd.com/read/28236267/pros-it-cnr-an-italian-prostate-cancer-monitoring-project
#17
Marianna Noale, Stefania Maggi, Walter Artibani, Pier Francesco Bassi, Filippo Bertoni, Sergio Bracarda, Giario Natale Conti, Renzo Corvò, Mauro Gacci, Pierpaolo Graziotti, Stefano Maria Magrini, Riccardo Maurizi Enrici, Vincenzo Mirone, Rodolfo Montironi, Giovanni Muto, Stefano Pecoraro, Angelo Porreca, Umberto Ricardi, Andrea Tubaro, Vittorina Zagonel, Filiberto Zattoni, Gaetano Crepaldi
AIMS: The Pros-IT CNR project aims to monitor a sample of Italian males ≥18 years of age who have been diagnosed in the participating centers with incident prostate cancer, by analyzing their clinical features, treatment protocols and outcome results in relation to quality of life. METHODS: Pros-IT CNR is an observational, prospective, multicenter study. The National Research Council (CNR), Neuroscience Institute, Aging Branch (Padua) is the promoting center...
February 24, 2017: Aging Clinical and Experimental Research
https://www.readbyqxmd.com/read/28233284/-brain-muscle-loop-in-the-fragility-of-older-persons-from-pathophysiology-to-new-organizing-models
#18
Fulvio Lauretani, Tiziana Meschi, Andrea Ticinesi, Marcello Maggio
BACKGROUND: The imperative action of the geriatric medicine is to prevent disability in older persons. Many epidemiological studies have been conducted in the last decades for improving knowledge of the aging process and their interactions with age-related diseases, especially for the identification of the relationship between sarcopenia and loss of mobility. Factors influencing muscle integrity can be classified into six main physiologic subsystems, but the central nervous system certainly plays a crucial role for maintaining muscle integrity in older persons...
February 23, 2017: Aging Clinical and Experimental Research
https://www.readbyqxmd.com/read/28233283/sarcopenia-and-sarcopenic-obesity-in-comparison-prevalence-metabolic-profile-and-key-differences-a-cross-sectional-study-in-italian-hospitalized-elderly
#19
Simone Perna, Gabriella Peroni, Faliva Milena Anna, Arianna Bartolo, Maurizio Naso, Alessandra Miccono, Mariangela Rondanelli
BACKGROUND: The aim of this study is to identify the prevalence, assess the metabolic profile, and key differences (versus healthy) in a cohort of subjects with sarcopenia (S) and in sarcopenic obesity (SO) hospitalized elderly. METHODS: A standardized comprehensive geriatric assessment was performed. We enrolled 639 elderly subjects (196 men, 443 women) with a mean age of 80.90 ± 7.77 years. Analysis of variance and a multinomial logistic regression analysis adjusting for covariates were used to assess the differences between groups...
February 23, 2017: Aging Clinical and Experimental Research
https://www.readbyqxmd.com/read/28224475/chronic-obstructive-pulmonary-disease-and-long-term-mortality-in-elderly-subjects-with-chronic-heart-failure
#20
Gianluca Testa, Francesco Cacciatore, Andrea Bianco, David Della-Morte, Francesca Mazzella, Gianluigi Galizia, Gaetano Gargiulo, Francesco Curcio, Ilaria Liguori, Alexandra Sabusco, Franco Rengo, Domenico Bonaduce, Pasquale Abete
BACKGROUND: Chronic heart failure (CHF) and chronic obstructive pulmonary disease (COPD) are associated with high rates of mortality in elderly subjects. Concurrent CHF and COPD frequently occur, especially in with advancing age. This study examines long-term mortality in community-dwelling elderly subjects affected by CHF alone, COPD alone, and coexistent CHF and COPD. METHODS: The study evaluated 12-years mortality in 1288 subjects stratified for the presence or absence of CHF or COPD alone, and for coexistence of CHF and COPD...
February 21, 2017: Aging Clinical and Experimental Research
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