Read by QxMD icon Read

Aging Clinical and Experimental Research

Nicola Vargas, Loredana Tibullo, Emanuela Landi, Giovanni Carifi, Alfonso Pirone, Antonio Pippo, Immacolata Alviggi, Renato Tizzano, Elisa Salsano, Francesco Di Grezia, Maria Vargas
Despite technological advances, the mortality rate for critically ill oldest old patients remains high. The intensive caring should be able to combine technology and a deep humanity considering that the patients are living the last part of their lives. In addition to the traditional goals of ICU of reducing morbidity and mortality, of maintaining organ functions and restoring health, caring for seriously oldest old patients should take into account their end-of-life preferences, the advance or proxy directives if available, the prognosis, the communication, their life expectancy and the impact of multimorbidity...
October 19, 2016: Aging Clinical and Experimental Research
Maryam Barma, Faisel Khan, Rosemary J G Price, Peter T Donnan, C Martina Messow, Ian Ford, Alex McConnachie, Allan D Struthers, Marion E T McMurdo, Miles D Witham
BACKGROUND: Growth differentiation factor-15 (GDF-15) may be a biomarker of disease, protective response and/or prognosis, in older people with hypertension. AIMS: To correlate baseline GDF-15 levels with physical and vascular health data in this population. METHODS: Baseline blood samples were analysed using a GDF-15 ELISA assay kit. Correlations with baseline and 12-month outcome data, including measures of physical and vascular function, were performed...
October 12, 2016: Aging Clinical and Experimental Research
Gloria Bonaccorsi, Enrica Fila, Carmelo Messina, Elisa Maietti, Fabio Massimo Ulivieri, Renata Caudarella, Pantaleo Greco, Giuseppe Guglielmi
PURPOSE: To evaluate (a) the performance in predicting the presence of bone fractures of trabecular bone score (TBS) and hip structural analysis (HSA) in type 2 diabetic postmenopausal women compared to a control group and (b) the fracture prediction ability of TBS versus Fracture Risk Calculator (FRAX(®)) as well as whether TBS can improve the fracture prediction ability of FRAX(®) in diabetic women. METHODS: Eighty diabetic postmenopausal women were matched with 88 controls without major diseases for age and body mass index...
October 8, 2016: Aging Clinical and Experimental Research
F Guerriero, C Sgarlata, M Francis, N Maurizi, A Faragli, S Perna, M Rondanelli, M Rollone, G Ricevuti
Due to an increasingly aging population, Alzheimer disease (AD) represents a crucial issue for the healthcare system because of its widespread prevalence and the burden of its care needs. Several hypotheses on AD pathogenesis have been proposed and current therapeutical strategies have shown limited effectiveness. In the last decade, more evidence has supported a role for neuroinflammation and immune system dysregulation in AD. It remains unclear whether astrocytes, microglia and immune cells influence disease onset, progression or both...
October 7, 2016: Aging Clinical and Experimental Research
Paolo Mazzola, Francesca Carissimi, Patrizia Floris, Francesca Pittella, Marianna Galeazzi, Daniela Moretti, Giuseppe Bellelli, Marco Dinelli, Giorgio Annoni
No abstract text is available yet for this article.
October 6, 2016: Aging Clinical and Experimental Research
Nikita L Frankenmolen, Eduard J Overdorp, Luciano Fasotti, Jurgen A H R Claassen, Roy P C Kessels, Joukje M Oosterman
BACKGROUND: Subjective memory complaints (SMC) are common among older adults, but it is unclear to what extent adults with SMC spontaneously use memory strategies to compensate for their memory problems. As SMC may be a risk factor for memory decline later, it is important to extend our knowledge about spontaneous compensatory mechanisms in older adults with SMC. METHOD: Self-reported strategy use and observed strategy use were assessed in 38 adults with and 38 without SMC...
October 5, 2016: Aging Clinical and Experimental Research
Daniela Gradinaru, Denisa Margina, Claudia Borsa, Cristina Ionescu, Mihaela Ilie, Marieta Costache, Anca Dinischiotu, Gabriel-Ioan Prada
OBJECTIVE: The aim of this study was to evaluate the relationships between the serum levels of adiponectin and systemic oxidative stress exerted on lipids, proteins, as well as endothelial function and cardiovascular diseases (CVD) risk markers, in elderly subjects with metabolic syndrome (MS). METHODS: The serum advanced glycation and oxidation protein products, low-density lipoprotein susceptibility to oxidation (oxLDL), nitric oxide metabolic pathway products (NOx), serum lipid peroxidation, as well as total antioxidant/oxidative capacity (TAC/TOC), were analyzed in elderly subjects with MS (n = 44), compared to aged-matched control (n = 39)...
September 29, 2016: Aging Clinical and Experimental Research
Rebecca M Henderson, X Iris Leng, Elizabeth A Chmelo, Tina E Brinkley, Mary F Lyles, Anthony P Marsh, Barbara J Nicklas
BACKGROUND: Little is known about the comparative effect of aerobic training (AT) versus resistance training (RT) on gait speed, a strong predictor of disability. AIMS: To compare the effect of AT versus RT on gait speed and other functional measures. METHODS: Overweight and obese [body mass index (BMI) ≥27.0 kg/m(2)] sedentary men and women aged 65-79 years engaged in 5 months of either 4 days/weeks moderate-intensity treadmill walking, AT, (n = 44) or 3 days/weeks moderate-intensity RT (n = 56)...
September 28, 2016: Aging Clinical and Experimental Research
Tomoyuki Kawada
No abstract text is available yet for this article.
September 28, 2016: Aging Clinical and Experimental Research
Anna-Karin Welmer, Debora Rizzuto, Marti G Parker, Weili Xu
BACKGROUND: Tooth loss has been linked to poor health such as chronic diseases and mobility limitations. Prospective evidence on the association between tooth loss and walking speed decline is however lacking. AIMS: To examine the impact of tooth loss on walking speed over time and explore whether inflammation may account for this association. METHODS: This study included 2695 persons aged 60 years and older, who were free from severe mobility limitation at baseline...
September 28, 2016: Aging Clinical and Experimental Research
Robert Wilk, Michał Skrzypek, Małgorzata Kowalska, Damian Kusz, Bogdan Koczy, Piotr Zagórski, Wojciech Pluskiewicz
BACKGROUND: Patients with hip fractures present a great challenge for surgeons due to multimorbidity, polypharmacy as well as difficulty in communicating. These could be attributed to a recent trend in the aging patient population (80 years and older) as compared to the past. The aim of this study is to analyze age structure and location in male and female patients' population with hip fracture over 50. MATERIALS AND METHODS: Hospital records between 2005 and 2014 with ICD-10 codes S72,0, S72,1 and S72,2 were included in the analysis...
September 6, 2016: Aging Clinical and Experimental Research
Ugo Carraro, Helmut Kern, Paolo Gava, Christian Hofer, Stefan Loefler, Paolo Gargiulo, Kyle Edmunds, Íris Dröfn Árnadóttir, Sandra Zampieri, Barbara Ravara, Francesco Gava, Alessandra Nori, Valerio Gobbo, Stefano Masiero, Andrea Marcante, Alfonc Baba, Francesco Piccione, Sheila Schils, Amber Pond, Simone Mosole
Many factors contribute to the decline of skeletal muscle that occurs as we age. This is a reality that we may combat, but not prevent because it is written into our genome. The series of records from World Master Athletes reveals that skeletal muscle power begins to decline at the age of 30 years and continues, almost linearly, to zero at the age of 110 years. Here we discuss evidence that denervation contributes to the atrophy and slowness of aged muscle. We compared muscle from lifelong active seniors to that of sedentary elderly people and found that the sportsmen have more muscle bulk and slow fiber type groupings, providing evidence that physical activity maintains slow motoneurons which reinnervate muscle fibers...
September 3, 2016: Aging Clinical and Experimental Research
Sara Morghen, Alessandro Morandi, Andrew A Guccione, Michela Bozzini, Fabio Guerini, Roberto Gatti, Francesco Del Santo, Simona Gentile, Marco Trabucchi, Giuseppe Bellelli
OBJECTIVES: To evaluate patients' participation during physical therapy sessions as assessed with the Pittsburgh rehabilitation participation scale (PRPS) as a possible predictor of functional gain after rehabilitation training. METHODS: All patients aged 65 years or older consecutively admitted to a Department of Rehabilitation and Aged Care (DRAC) were evaluated on admission regarding their health, nutritional, functional and cognitive status. Functional status was assessed with the functional independence measure (FIM) on admission and at discharge...
September 2, 2016: Aging Clinical and Experimental Research
Chiung-Ju Liu, Deana Marie, Aaron Fredrick, Jessica Bertram, Kristen Utley, Elaine Ewing Fess
BACKGROUND: Hand function is critical for independence in activities of daily living for older adults. AIMS: The purpose of this study was to examine how grip strength, arm curl strength, and manual dexterous coordination contributed to time-based versus self-report assessment of hand function in community-dwelling older adults. METHODS: Adults aged ≥60 years without low vision or neurological disorders were recruited. Purdue Pegboard Test, Jamar hand dynamometer, 30-second arm curl test, Jebsen-Taylor Hand Function Test, and the Late-Life Function and Disability Instrument were administered to assess manual dexterous coordination, grip strength, arm curl strength, time-based hand function, and self-report of hand function, respectively...
August 30, 2016: Aging Clinical and Experimental Research
Busra Can, Ozgur Kara, Muhammet Cemal Kizilarslanoglu, Gunes Arik, Gozde Sengul Aycicek, Fatih Sumer, Ramazan Civelek, Canan Demirtas, Zekeriya Ulger
BACKGROUND: Sarcopenia is a geriatric syndrome characterized by the presence of low muscle mass and function. Possible mechanisms underlying sarcopenia include oxidative stress and elevation of inflammatory cytokines. AIMS: The aim of the study was to evaluate the relationship between sarcopenia and biomarkers that may be involved in its pathogenesis and hence early detection. METHODS: A total of 72 patients (36 sarcopenic and 36 non-sarcopenic) were included in the study...
August 29, 2016: Aging Clinical and Experimental Research
Giuseppe Sergi, Marina De Rui, Brendon Stubbs, Nicola Veronese, Enzo Manzato
The assessment of body composition has important applications in the evaluation of nutritional status and estimating potential health risks. Bioelectrical impedance analysis (BIA) is a valid method for the assessment of body composition. BIA is an alternative to more invasive and expensive methods like dual-energy X-ray absorptiometry, computerized tomography, and magnetic resonance imaging. Bioelectrical impedance analysis is an easy-to-use and low-cost method for the estimation of fat-free mass (FFM) in physiological and pathological conditions...
August 27, 2016: Aging Clinical and Experimental Research
Stefano Fumagalli, Ilaria Giannini, Simone Pupo, Francesca Agostini, Serena Boni, Anna T Roberts, Debbie Gabbai, Claudia Di Serio, Luciano Gabbani, Francesca Tarantini, Niccolò Marchionni
BACKGROUND AND AIMS: Atrial fibrillation (AF) is the most frequent arrhythmia of the elderly, and electrical cardioversion (ECV) is a common procedure, although incidence of recurrences remains high. We evaluated the possible association between arterial stiffness (AS) and the persistence or recurrence of AF in elderly patients after ECV. METHODS: We enrolled all subjects undergoing ECV over a 9-month period. AS was evaluated with the cardio-ankle vascular index (CAVI)...
August 27, 2016: Aging Clinical and Experimental Research
Stefano Poli, Alberto Cella, Matteo Puntoni, Clarissa Musacchio, Monica Pomata, Domenico Torriglia, Natalia Vello, Beba Molinari, Valeria Pandolfini, Claudio Torrigiani, Alberto Pilotto
BACKGROUND AND AIMS: This study assessed the association between frailty and sociodemographic, socioeconomic and lifestyle factors in community-dwelling older people. METHODS: This was a cross-sectional survey in a population-based sample of 542 community-dwelling subjects aged 65 years and older living in a metropolitan area in Italy. Frailty was evaluated by means of the FRAIL scale proposed by the International Association of Nutrition and Aging. Basal and instrumental activities of daily living (ADL, IADL), physical activity, sociodemographic (age, gender, marital status and cohabitation), socioeconomic (education, economic conditions and occupational status) and lifestyle domains (cultural and technological fruition and social activation) were assessed through specific validated tools...
August 27, 2016: Aging Clinical and Experimental Research
Valentina Spedale, Stefania Di Mauro, Giulia Del Giorno, Monica Barilaro, Candida E Villa, Jean D Gaudreau, Davide Ausili
BACKGROUND: Delirium has a high incidence pathology associated with negative outcomes. Although highly preventable, half the cases are not recognized. One major cause of delirium misdiagnosis is the absence of a versatile instrument to measure it. AIMS: Our objective was to translate the nursing delirium screening scale (Nu-DESC) and evaluate its performance in Italian settings. METHODS: This was a methodological study conducted in two sequential phases...
August 27, 2016: Aging Clinical and Experimental Research
Mitsuhiro Aoki
BACKGROUND: The elderly often complain of faintness, lightheadedness, dizziness, and unsteadiness, which may be associated with the orthostatic hypotension (OH), but most of them are subclinical. The pathogenic mechanism of subjective symptoms in the elderly with OH is controversial. AIMS: The aim of this study was to assess the involvement of the irregularity of the vertical perception in the dizzy elderly with OH. METHODS: This study consisted of 403 patients seeking treatment for dizziness in our hospital...
August 27, 2016: Aging Clinical and Experimental Research
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"