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Aging Clinical and Experimental Research

Jan Schjøtt
Questions from physicians to regional medicines information and pharmacovigilance centres in Norway (RELIS) concerning older patients were described. Question-answer pairs (QAPs) from the RELIS database indexed with the category "older", and concerning individual patients from the period 01 Jan 2010 to 31 Dec 2015, were analysed. Two-hundred and eight QAPs categorized with "older" were retrieved from a total of 16 710 in the study period, and 122 of 208 QAPs fulfilled the inclusion criteria. The most common categories of drugs in question (n = 228) according to the ATC system were N: Nervous system (30...
September 19, 2017: Aging Clinical and Experimental Research
Atefeh Aboutorabi, Mokhtar Arazpour, Mahmood Bahramizadeh, Farzam Farahmand, Reza Fadayevatan
BACKGROUND AND AIM: Gait and balance disorders are common in the elderly populations, and their prevalence increases with age. This systematic review was performed to summarize the current evidence for subthreshold vibration interventions on postural control and gait in elderly. METHOD: A review of intervention studies including the following words in the title/abstract: insole, foot and ankle appliances, vibration, noise and elderly related to balance and gait...
September 16, 2017: Aging Clinical and Experimental Research
Sajjad Moradi, Leila Khorrami-Nezhad, Sima Ali-Akbar, Fatemeh Zare, Tanaz Alipour, Azadeh Dehghani Kari Bozorg, Mir Saeed Yekaninejad, Zhila Maghbooli, Khadijeh Mirzaei
BACKGROUND/OBJECTIVE: Recent studies have shown that dietary variants and genetic variants play a decisive role in the risk of developing osteoporosis. Therefore, the objective of the present study was to examine associations between dietary pattern and bone health, according to the TGF-β1 T869→C polymorphism, in postmenopausal Iranian women. MATERIALS AND METHODS: In this study, 264 postmenopausal women aged from 46 to 78 years were examined. Body composition was measured by a body composition analyzer and physical activity by the short-form physical activity questionnaire...
September 16, 2017: Aging Clinical and Experimental Research
Burcu Başarık Aydoğan, Fatma Yıldırım, Avşar Zerman, Kamil Gönderen, Melda Türkoğlu, Gülbin Aygencel
OBJECTIVE: Most significant side effect of colistin therapy which is used for the treatment of multi-drug resistant Gram-negative infections is nephrotoxicity. Our aim was to investigate the differences of colistin nephrotoxicity between the geriatric age group (≥65 years) and the younger age group (<65 years) in critically ill medical intensive care unit (ICU) patients. MATERIAL AND METHOD: The medical records of the 76 patients who were taken colistin therapy due to multi-resistant Gram-negative infections between January 2010 and June 2014 in the our medical ICU were retrospectively investigated...
September 2, 2017: Aging Clinical and Experimental Research
Anna C Whittaker, Massimo Delledonne, Taija Finni, Paolo Garagnani, Carolyn Greig, Victor Kallen, Katja Kokko, Janet Lord, Andrea B Maier, Carel G M Meskers, Nadine Correia Santos, Sarianna Sipila, Janice L Thompson, Natal van Riel
No abstract text is available yet for this article.
September 1, 2017: Aging Clinical and Experimental Research
Omer Karasahin, Pınar Tosun Tasar, Ozge Timur, Filiz Yıldırım, Dogan Nasır Binici, Sevnaz Sahin
BACKGROUND: The aim of this study was to determine the value of C-reactive protein level in the diagnosis and prognosis of infection in elderly patients. STUDY POPULATION: This prospective study included inpatients in the palliative care unit during the 1-year period between January 2016 and January 2017. Patients' demographic data, Acute Physiology and Chronic Health Evaluation score, and Charlson Comorbidity Index were recorded. RESULTS: A total of 233 patients were included in the study...
August 30, 2017: Aging Clinical and Experimental Research
Anna-Luisa Klotz, Alexander Jochen Hassel, Johannes Schröder, Peter Rammelsberg, Andreas Zenthöfer
AIM: The objective of this controlled clinical study was to evaluate the association between oral health and 1-year mortality among nursing home residents with or without oral health intervention. METHODS: This research was part of a multidisciplinary intervention study (EVI-P) performed in 14 nursing homes in Germany. Two-hundred and nineteen nursing home residents were included in the study and assigned to an intervention group, for which dental health education was offered and ultrasonic baths were used for denture cleaning (n = 144), or to a control group (n = 75)...
August 30, 2017: Aging Clinical and Experimental Research
Giuseppe De Vincentis, Giulia Anna Follacchio, Viviana Frantellizzi, Arsela Prelaj, Alessio Farcomeni, Angelo Giuli, Vincenzo Bianco, Silverio Tomao
No abstract text is available yet for this article.
August 30, 2017: Aging Clinical and Experimental Research
Izabella Uchmanowicz, Maria Kuśnierz, Marta Wleklik, Beata Jankowska-Polańska, Joanna Jaroch, Krystyna Łoboz-Grudzień
BACKGROUND: Heart failure (HF) patients with frailty syndrome (FS) are at higher risk of falling, decreased mobility, ability to perform the basic activities of daily living, frequent hospitalizations, and death. AIMS: The purpose of this study was to evaluate the correlations between FS and hospital readmissions, and to assess which factors are associated with rehospitalizations. METHODS: The study included 330 patients with a mean age of 72...
August 28, 2017: Aging Clinical and Experimental Research
Luca Rozzini, Marta Zaffira Conti, Maddalena Riva, Anna Ceraso, Salvatore Caratozzolo, Marina Zanetti, Alessandro Padovani
BACKGROUND: Prior studies documented that several sleep disorders may coexist in patients affected by Mild Cognitive Impairment (MCI) and Alzheimer disease (AD), and have a strong bidirectional relationship with cognitive decline. AIM: To assess the self-reported sleep quality and daytime sleepiness among subjects affected by MCI and AD at early-stage and healthy controls, and to verify if sleep disturbances might be an indicator of specific cognitive deficits. METHODS: 139 patients (102 MCI, 37 AD) underwent comprehensive neuropsychological, functional, and behavioral assessment, which also included Epworth Sleepiness Scale (ESS) and Pittsburgh Sleep Quality Index (PSQI)...
August 28, 2017: Aging Clinical and Experimental Research
Ralf Suhr, Nils Axel Lahmann
OBJECTIVES: The objective of the study was to determine the prevalence and severity of urinary incontinence and associated factors in patients receiving home care nursing service. METHODS: From June to September 2015, a multicenter cross-sectional study was conducted in 923 patients from 102 home care services throughout Germany. The ICIQ-SF was used to determine the characteristics of UI and its impact on QoL. To determine the risks for UI, demographic and social risks, the Barthel Index and medical diagnoses were determined in descriptive and logistic regression analysis...
August 23, 2017: Aging Clinical and Experimental Research
Patrick J Sparto, A B Newman, E M Simonsick, P Caserotti, E S Strotmeyer, S B Kritchevsky, K Yaffe, C Rosano
BACKGROUND: In older adults, impaired control of standing balance in the lateral direction is associated with the increased risk of falling. Assessing the factors that contribute to impaired standing balance control may identify areas to address to reduce falls risk. AIM: To investigate the contributions of physiological factors to standing lateral balance control. METHODS: Two hundred twenty-two participants from the Pittsburgh site of the Health, Aging and Body Composition Study had lateral balance control assessed using a clinical sensory integration balance test (standing on level and foam surface with eyes open and closed) and a lateral center of pressure tracking test using visual feedback...
August 23, 2017: Aging Clinical and Experimental Research
Ove Spreckelsen, Andres Luque Ramos, Michael Freitag, Falk Hoffmann
BACKGROUND: Influenza vaccination is highly recommended for nursing home residents. However, it is known that vaccination coverage is low in the general population. AIMS: We aim to find out whether influenza vaccination coverage differs for nursing home residents between the year before and after admission and factors determining the chance to receive vaccination. METHODS: Claims data of the health insurance fund DAK of at least 65-year-olds were used...
August 23, 2017: Aging Clinical and Experimental Research
Mariane Eichendorf da Silva, Lucas Bet da Rosa Orssatto, Ewertton de Souza Bezerra, Diego Augusto Santos Silva, Bruno Monteiro de Moura, Fernando Diefenthaeler, Cíntia de la Rocha Freitas
BACKGROUND: Accuracy is essential to the validity of functional capacity measurements. AIM: To evaluate the error of measurement of functional capacity tests for elders and suggest the use of the technical error of measurement and credibility coefficient. METHODS: Twenty elders (65.8 ± 4.5 years) completed six functional capacity tests that were simultaneously filmed and timed by four evaluators by means of a chronometer. A fifth evaluator timed the tests by analyzing the videos (reference data)...
August 23, 2017: Aging Clinical and Experimental Research
Elena Sinforiani, Sara Bernini, Marta Picascia
We report an update of our previous observations in Alzheimer's disease (AD) patients in the routine clinical practice considering in particular the interactions between age, concomitant pathologies, and treatment adherence. 2379 AD patients (M/F: 1058/1321, mean age: 74.1 ± 8.8) referred for a first visit to our center from September 2000 to April 2017. An increase of percentage of patients aged over 80 years along the years was confirmed (27% between September 2000 and December 2010, and 39% between January 2011 to April 2017)...
August 21, 2017: Aging Clinical and Experimental Research
Luca Pellizzari, Roberto Facchinetti, Luigi Corrà, Anna Sepe, Francesco Fantin, Giorgia Fontana, Mauro Zamboni, Vincenzo Di Francesco
OBJECTIVES: The aim of this study was to evaluate the activity of anti-activated factor X (anti-Xa) in patients with different degrees of chronic renal failure (CRF), treated with therapeutic doses of low molecular weight heparin. DESIGN: This prospective study evaluated the effect of age, renal function, BMI, gender, in determining the efficacy and safety of treatment with enoxaparin, evaluated by assessing the anti-Xa. The therapeutic anticoagulant range was set between 0...
August 14, 2017: Aging Clinical and Experimental Research
Iskender Kara, Muge Aydogdu, Gul Gursel
No abstract text is available yet for this article.
August 14, 2017: Aging Clinical and Experimental Research
Nicola Vargas, Antonio M Esquinas
No abstract text is available yet for this article.
August 14, 2017: Aging Clinical and Experimental Research
Elif Carpar, Geraldine McCarthy, Dimitrios Adamis, Gizem Donmezler, Ender Cesur, Nurhan Fistikci
BACKGROUND: Taking predictors of hospitalization characteristics into consideration internationally would broaden our understanding of this population on a local basis. AIMS: We aimed to examine and compare socio-demographic profiles along with hospitalization characteristics including length of hospital stay (LOS), reasons for admission and diagnoses among older adult inpatients hospitalized in Ireland and Turkey, and to assess factors predicting these features...
August 14, 2017: Aging Clinical and Experimental Research
Bernardo Gialanella, Paola Prometti, Vittoria Monguzzi, Cristina Ferlucci, Paola Baiardi, Laura Comini
BACKGROUND AND AIMS: Executed studies did not clearly identify which index of comorbidity was an independent outcome determinant. The aim of this prospective observational cohort study was to address this issue. METHODS: We analyzed 200 consecutive patients with hip fracture. All patients underwent rehabilitation. At admission comorbidity was assessed through the cumulative severity, severity index, and comorbidity index of the Cumulative Illness Rating Scale. Discharge scores and effectiveness in the Functional Independence Measure motor subscale, and discharge destination were the outcome measures...
August 12, 2017: Aging Clinical and Experimental Research
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