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Aging Clinical and Experimental Research

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https://www.readbyqxmd.com/read/29139067/thromboembolic-and-bleeding-risk-management-in-elderly-patients-a-case-report
#1
Michele Cellurale, Ilaria Liguori, Francesco Curcio, Antonio Rapacciuolo, Nicola Ferrara, Domenico Bonaduce, Pasquale Abete
No abstract text is available yet for this article.
November 14, 2017: Aging Clinical and Experimental Research
https://www.readbyqxmd.com/read/29128999/impact-of-potentially-inappropriate-medications-and-polypharmacy-on-3-month-readmission-among-older-patients-discharged-from-acute-care-hospital-a-prospective-study
#2
Paolo Fabbietti, Giuseppina Di Stefano, Raffaella Moresi, Laura Cassetta, Mirko Di Rosa, Filippo Fimognari, Valentina Bambara, Giovanni Ruotolo, Alberto Castagna, Carmen Ruberto, Fabrizia Lattanzio, Andrea Corsonello
BACKGROUND: Polypharmacy and potentially inappropriate medications (PIMs) are known to affect several negative outcomes in older patients. However, studies comparatively assessing polypharmacy and PIMs in relation to readmission are distinctively lacking. AIMS: To compare the impact of polypharmacy and PIMs on 3-month readmission among older patients discharged from acute care hospital. METHODS: Our series consisted of 647 patients consecutively enrolled in a multicenter observational study...
November 11, 2017: Aging Clinical and Experimental Research
https://www.readbyqxmd.com/read/29124524/high-comorbidity-measured-by-the-charlson-comorbidity-index-associates-with-higher-1-year-mortality-risks-in-elderly-patients-experiencing-a-first-acute-heart-failure-hospitalization
#3
Francesc Formiga, Rafael Moreno-Gonzalez, David Chivite, Jonathan Franco, Abelardo Montero, Xavier Corbella
BACKGROUND: Comorbidity is related to poor health results in chronic heart failure (HF). AIMS: The purpose of the study was to assess whether a high Charlson Comorbidity Index score (CCI) relates to 1 year mortality after a first hospitalization for acute HF (AHF). METHODS: We reviewed the medical records of 897 patients > 65 years of age admitted within a two-year period because of a first episode of AHF. We analyzed two groups: low (CCI ≤ 2) and high (CCI > 2) comorbidity...
November 9, 2017: Aging Clinical and Experimental Research
https://www.readbyqxmd.com/read/29101670/concordance-between-clinical-and-radiographic-evaluations-of-knee-osteoarthritis
#4
Camille Parsons, Nicholas R Fuggle, Mark H Edwards, Lyndsey Goulston, Anna E Litwic, Darshan Jagannath, Suzan van der Pas, Cyrus Cooper, Elaine M Dennison
BACKGROUND: Significant correlation has been previously demonstrated between radiographic and clinical diagnoses of knee osteoarthritis (OA); however, the specific findings on clinical examination that relate best to a radiographic diagnosis have not been fully elicited. AIMS: We aimed to explore the relationship between clinical symptoms and physical findings with radiographic diagnoses of tibiofemoral and patellofemoral OA. METHODS: This study was based on 409 individuals from the Hertfordshire Cohort Study, born between 1931 and 1939...
November 3, 2017: Aging Clinical and Experimental Research
https://www.readbyqxmd.com/read/29080052/atraumatic-femoral-neck-fracture-during-bisphosphonate-treatment-case-report-and-review-of-the-literature
#5
Robert Wilk, Damian Kusz, Hanna Grygiel, Magdalena Grosiak, Jakub Kamiński, Marcin Kusz
No abstract text is available yet for this article.
October 27, 2017: Aging Clinical and Experimental Research
https://www.readbyqxmd.com/read/29076111/when-climate-change-encounters-the-revolution-in-adult-longevity
#6
EDITORIAL
Jean-Marie Robine
No abstract text is available yet for this article.
October 26, 2017: Aging Clinical and Experimental Research
https://www.readbyqxmd.com/read/29071664/the-relationship-between-plasma-interleukin-15-levels-and-sarcopenia-in-outpatient-older-people
#7
Ahmet Yalcin, Kamile Silay, Ahmet Rifat Balik, Gamze Avcioğlu, Almila Senat Aydin
BACKGROUND AND AIM: Sarcopenia is a geriatric syndrome in which there is a decrease in muscle mass, muscle strength, and muscle function. Interleukin-15 (IL-15), a myokine released by skeletal muscle, has effects on both muscle and adipose tissue. We evaluated the relationship between plasma IL-15 level and sarcopenia. METHODS: We evaluated a total of 160 outpatient older people, and 80 of whom had sarcopenia. Sarcopenia was defined according to the European Working Group on Sarcopenia in Older People criteria...
October 25, 2017: Aging Clinical and Experimental Research
https://www.readbyqxmd.com/read/29063490/effect-of-somatosensory-and-neurofeedback-training-on-balance-in-older-healthy-adults-a-preliminary-investigation
#8
Atefeh Azarpaikan, Hamidreza Taheri Torbati
The aim of this study was to assess the effectiveness of balance training with somatosensory and neurofeedback training on dynamic and static balance in healthy, elderly adults. The sample group consisted of 45 healthy adults randomly assigned to one of the three test groups: somatosensory, neurofeedback, and a control. Individualization of the balance program started with pre-tests for static and dynamic balances. Each group had 15- and 30-min training sessions. All groups were tested for static (postural stability) and dynamic balances (Berg Balance Scale) in acquisition and transfer tests (fall risk of stability and timed up and go)...
October 23, 2017: Aging Clinical and Experimental Research
https://www.readbyqxmd.com/read/29058269/muscle-strength-functional-endurance-and-health-related-quality-of-life-in-active-older-female-golfers
#9
Charlotte Buckley, Maria Stokes, Dinesh Samuel
BACKGROUND: Grip strength is a reliable predictor of whole body strength in older adults, but muscle characteristics of people with different activity levels have not been studied previously. The present study examined the relationship between grip strength (GS), quadriceps peak torque (QPT), functional endurance, and health-related quality of life (HRQoL) in older female golfers. METHODS: Twenty-nine healthy female golfers (mean age 69.1 years, SD 3.4) participated...
October 23, 2017: Aging Clinical and Experimental Research
https://www.readbyqxmd.com/read/29052801/coronary-flow-response-to-remote-ischemic-preconditioning-is-preserved-in-old-cardiac-patients
#10
Elpidio Santillo, Monica Migale, Fabrizio Balestrini, Demetrio Postacchini, Silvia Bustacchini, Fabrizia Lattanzio, Raffaele Antonelli-Incalzi
BACKGROUND: The effect of remote ischemic preconditioning (RIPC) on coronary flow in elderly cardiac patients has not been investigated yet. Thus, we aimed to study the change of coronary flow subsequent to RIPC in old patients with heart diseases and to identify its main correlates. METHODS: Ninety-five elderly patients (aged ≥ 65 years) accessing cardiac rehabilitation ward underwent transthoracic ultrasound evaluation of peak diastolic flow velocity of left anterior descending artery...
October 20, 2017: Aging Clinical and Experimental Research
https://www.readbyqxmd.com/read/29052034/high-molecular-weight-adiponectin-levels-in-healthy-community-dwelling-elderly-japanese-volunteers-a-5-year-prospective-observational-study
#11
Hiromasa Otsuka, Mitsuru Yanai, Hiroki Kobayashi, Akira Haketa, Motohiko Hara, Kaoru Sugama, Kimitoshi Kato, Masayoshi Soma
BACKGROUND: Serum adiponectin levels are associated with frailty and cardiovascular diseases. Longitudinal changes in adiponectin levels might enhance our understanding of age-related conditions and diseases. AIMS: This prospective observational study aimed to: (1) elucidate age-related changes in high-molecular-weight (HMW) adiponectin levels; and (2) identify variables predictive of elevated HMW adiponectin levels and the association with well-known adiponectin single-nucleotide polymorphisms (SNPs) in healthy, elderly Japanese participants...
October 19, 2017: Aging Clinical and Experimental Research
https://www.readbyqxmd.com/read/29032522/comparative-characteristic-of-antimicrobial-resistance-in-geriatric-hospital-a-retrospective-cohort-study
#12
G Goltsman, E H Mizrahi, A Leibovitz, G Gal, O Gorelik, E Lubart
BACKGROUND AND AIMS: To examine antimicrobial resistance of commonly isolated pathogens in elderly hospitalized patients. METHODS: Data regarding all clinically significant isolates from blood and urine cultures of patients admitted to a multilevel geriatric hospital during March 2015 to April 2016 were collected. Antimicrobial susceptibility testing was performed according to Clinical and Laboratory Standard Institute guidelines. RESULTS: Escherichia coli, Proteus mirabilis, and Klebsiella pneumoniae were the most common isolates, with proportions of extended spectrum beta-lactamase positivity of 60, 40, and 61% respectively...
October 14, 2017: Aging Clinical and Experimental Research
https://www.readbyqxmd.com/read/29027613/both-decreased-akt-expression-and-mtor-phosphorylation-are-related-to-decreased-neuronal-differentiation-in-the-hippocampal-alveus-of-aged-mice
#13
Bing Chun Yan, Dan Jiang, Jie Wang, Yuanyuan Zhang, Xiaolu Zhu, Pei Xu, Xing Yu, Moo-Ho Won, Pei Qing Su
BACKGROUND: Aging is an inevitable process which results in many changes. These changes are closely related to the hippocampus which is in charge of long-term learning and episodic memory. AIM: This study was to investigate age-related changes of the cell proliferation, neuroblast differentiation and Akt/mTOR signaling in the hippocampal alveus of aged mice. METHODS: In the present study, we compared the differences of neurogenesis in the hippocampal alveus between adult (postnatal month 6) and aged (postnatal month 24) mice using immunohistochemistry and western blot analysis...
October 13, 2017: Aging Clinical and Experimental Research
https://www.readbyqxmd.com/read/29022278/alzheimer-caf%C3%A3-an-approach-focused-on-alzheimer-s-patients-but-with-remarkable-values-on-the-quality-of-life-of-their-caregivers
#14
Paola Merlo, Maria Devita, Alessandra Mandelli, Maria Luisa Rusconi, Raquel Taddeucci, Alice Terzi, Gianpiero Arosio, Maria Bellati, Maura Gavazzeni, Sara Mondini
BACKGROUND: Alzheimer's disease (AD) affects the global quality of life of persons who suffer from it and their caregivers, because of the behavioral and psychological consequences associated with the pathology and its caring. The Alzheimer Café (AC) is one example of approach aimed to help persons and caregivers deal with their disease. AIM: This is a pilot study focusing on the efficacy of AC in relieving caregivers' and persons' burdens due to dementia. METHODS: The quality of life of both caregivers and persons who attended the AC was compared with the quality of life of those who did not...
October 11, 2017: Aging Clinical and Experimental Research
https://www.readbyqxmd.com/read/29022271/a-comparison-of-six-clock-drawing-test-scoring-methods-in-a-nursing-home
#15
Linhui Chen, Shanhu Xu, Xiaoqing Jin, Xingjiao Lu, Lu Liu, Yue Lou, Yanwen Wang, Yaguo Li, Yu Jin
BACKGROUND: Clock-drawing test (CDT) is widely used but lack of a suitable scoring method. AIMS: To compare the validity of six common CDT scoring methods and to find out the best one. METHODS: The drawing CDT was administered in a Chinese nursing-home inhabitants living on the mainland including 110 dementia, 118 MCI (mild cognitive impairment), and 133 random normal. We calculated the sensitivity and specificity of six scoring methods and applied the receiver-operating characteristic (ROC) curve statistic, including determining the area under the curve (AUC)...
October 11, 2017: Aging Clinical and Experimental Research
https://www.readbyqxmd.com/read/29022191/the-association-between-subjectively-impaired-sleep-and-symptoms-of-depression-and-anxiety-in-a-frail-elderly-population
#16
Yan Press, Boris Punchik, Tamar Freud
BACKGROUND: Most previous studies showed an association between sleep impairment in the elderly and symptoms of depression and anxiety. Majority of these studies were conducted in "strong", community-dwelling elderly. AIM: To assess the association between subjective sleep impairment and its affective disturbances among frail elderly patients. METHODS: The retrospective study included patients 65 years old and above. Data included socio-demographic characteristics, the mini-mental state examination, the short anxiety screening test, the 15-item Geriatric Depression Scale, and the Patient Health Questionnaire...
October 11, 2017: Aging Clinical and Experimental Research
https://www.readbyqxmd.com/read/29019160/the-role-of-cognitive-reserve-in-cognitive-aging-what-we-can-learn-from-parkinson-s-disease
#17
Nicoletta Ciccarelli, Maria Rita Lo Monaco, Domenico Fusco, Davide Liborio Vetrano, Giuseppe Zuccalà, Roberto Bernabei, Vincenzo Brandi, Maria Stella Pisciotta, Maria Caterina Silveri
Parkinson's disease (PD) typically occurs in elderly people and some degree of cognitive impairment is usually present. Cognitive reserve (CR) theory was proposed to explain the discrepancy between the degree of brain pathologies and clinical manifestations. We administered a comprehensive neuropsychological battery to 35 non-demented participants affected by PD. All participants underwent also the Cognitive Reserve Index questionnaire and the Brief Intelligence Test as proxies for CR. Relationships between CR and cognitive performance were investigated by linear regression analyses, adjusting for significant confounding factors...
October 11, 2017: Aging Clinical and Experimental Research
https://www.readbyqxmd.com/read/28980220/feasibility-of-a-machine-vs-free-weight-strength-training-program-and-its-effects-on-physical-performance-in-nursing-home-residents-a-pilot-study
#18
Bettina Johnen, Nadja Schott
BACKGROUND: Resistance training holds promise for nursing home residents to prevent further disabilities, falls, and fractures. Free weight as well as machine training may offer an efficient option to improve physical performance, but the feasibility of these training regimes among elderly who require continuous institutional care is still open. AIMS: (1) To examine the feasibility of a 3-month machine vs. free weight strength training program in institutionalized older adults, and (2) to determine the effects on physical performance...
October 4, 2017: Aging Clinical and Experimental Research
https://www.readbyqxmd.com/read/28980176/effects-of-dance-practice-on-functional-mobility-motor-symptoms-and-quality-of-life-in-people-with-parkinson-s-disease-a-systematic-review-with-meta-analysis
#19
REVIEW
Marcela Dos Santos Delabary, Isabel Giovannini Komeroski, Elren Passos Monteiro, Rochelle Rocha Costa, Aline Nogueira Haas
BACKGROUND: Patients with Parkinson's Disease (PD) undergo motor injuries, which decrease their quality of life (QL). Dance, added to drug therapy, can help treating these patients AIMS: To conduct a systematic review with meta-analysis with the aim to analyze the effects of dance classes in comparison to other interventions or to the absence of intervention, in randomized clinical trials (RCTs), on functional mobility, motor symptoms and QL of PD patients METHODS: The search was conducted in MEDLINE, LILACS, SciELO, Cochrane and PsycINFO (last searched in August 2017)...
October 4, 2017: Aging Clinical and Experimental Research
https://www.readbyqxmd.com/read/28952131/dynamic-changes-in-p66shc-mrna-expression-in-peripheral-blood-mononuclear-cells-following-resistance-training-intervention-in-old-frail-women-born-to-obese-mothers-a-pilot-study
#20
Alessandra Berry, Marco Bucci, Carla Raggi, Johan G Eriksson, Maria Angela Guzzardi, Pirjo Nuutila, Ville Huovinen, Patricia Iozzo, Francesca Cirulli
The p66Shc gerontogene may affect healthspan by promoting fat accumulation. We assessed changes of p66Shc-mRNA in peripheral tissues in relation to maternal obesity and the moderating effects of resistance-training (RT) exercise in elderly frail women. Thirty-seven women participated in a 4-month RT program. Twenty were offspring of lean/normal weight mothers and 17 were offspring of overweight/obese mothers (OOM). P66Shc was assessed in peripheral blood mononuclear cells (PBMC) and in subcutaneous adipose tissue (SAT) before and after RT...
September 26, 2017: Aging Clinical and Experimental Research
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