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Aging Clinical and Experimental Research

Marcos Rossi-Izquierdo, Pilar Gayoso-Diz, Sofía Santos-Pérez, María Del-Río-Valeiras, Ana Faraldo-García, Isabel Vaamonde-Sánchez-Andrade, Antonio Lirola-Delgado, Andrés Soto-Varela
BACKGROUND: Our previous study had shown the effectiveness of vestibular rehabilitation (VR) in improving balance in elderly patients, assessed immediately afterwards. AIMS: The main goal of the present study is to consider whether this improvement in balance assessment turns out in a reduction of the number of falls. METHODS: 139 elderly patients with high risk of falls were included and randomized to one of the following study arms: computerized dynamic posturography (CDP) training, optokinetic stimulus, exercises at home or control group...
July 14, 2018: Aging Clinical and Experimental Research
Susan Stephanie Reedy, William Spassini, Nicola Berruti, Berti Stefano, Renzo Polotti, Orazio Zanetti
No abstract text is available yet for this article.
July 13, 2018: Aging Clinical and Experimental Research
Zhihui Li, Xin Peng, Wei Xiang, Jiaqi Han, Kun Li
BACKGROUND: Aging is often accompanied by decline in aspects of cognitive function. Cognitive decline has harmful effects on living independence and general health. Resistance training is seen as a promising intervention to prevent or delay cognitive deterioration, yet the evidence from reviews is less consistent. AIM: To assess the effect of resistance training on cognition in the elderly with and without mild cognitive impairment and to provide an up-to-date overview...
July 13, 2018: Aging Clinical and Experimental Research
Ahmed Ghachem, Jean-Christophe Lagacé, Martin Brochu, Isabelle J Dionne
BACKGROUND: A greater fat-free mass (FFM) is purported to be associated with protective effects on insulin resistance (IR). However, recent studies suggested negative associations between FFM and IR. OBJECTIVES: (1) To explore the direction of the association between FFM and IR in a large heterogeneous sample after controlling for confounding factors. (2) To determine cut off values of FFM associated with an increased risk of IR. METHODS: Outcome variables were measured in 7044 individuals (48...
July 10, 2018: Aging Clinical and Experimental Research
Lawrence Adekunle Adebusoye, Mayowa Owolabi, Adesola Ogunniyi
BACKGROUND: Older people face the biggest challenges in the overburdened healthcare services in Nigeria especially when hospitalized. There is no reliable data on the predictors of mortality in this population. AIMS: To determine the predictors of mortality among older patients on admission in the medical wards of University College Hospital, Ibadan. METHODS: Using a prospective cohort design, we investigated 450 patients (> 60 years) from the day of admission to death or discharge...
July 6, 2018: Aging Clinical and Experimental Research
Antoine Langeard, Kristell Pothier, Nathalie Chastan, Christian Marcelli, Chantal Chavoix, Nicolas Bessot
BACKGROUND: While most fractures are caused by falls, not all falls result in fractures. Risk factors for falls are well established, but only weak associations have been demonstrated for risk factors for fractures. Conflicting results on the implication of bone mineral density (BMD) suggest that other risk factors should be studied, such as gait and balance disorders. AIMS: Gait and postural stability in challenging conditions were, therefore, compared between fallers with and without fracture...
July 4, 2018: Aging Clinical and Experimental Research
Toshiki Kutsuna, Yoshinori Hiyama, Satomi Kusaka, Yasuaki Kusumoto, Junko Tsuchiya, Masaru Umeda, Tetsuya Takahashi
BACKGROUND: Slow walking speed as one indicator of physical frailty has been found to be associated with deterioration of the health status. Although many reports have shown that exercise training improves motor function, it is unclear whether a group-based and short-term health promotion intervention will improve motor function in older adults. AIMS: This study aimed to examine the effectiveness of a short-term health promotion intervention on motor function in community-dwelling older adults...
July 3, 2018: Aging Clinical and Experimental Research
Roberto Fogari, Alfredo Costa, Annalisa Zoppi, Angela D'Angelo, Natascia Ghiotto, Domenico Battaglia, Matteo Cotta Ramusino, Giulia Perini, Daniele Bosone
BACKGROUND: No study has evaluated the cardiovascular effects of diazepam in elderly subjects that assume diazepam to induce sleep. PURPOSE: The present study was carried out in order to evaluate the effects of chronic administration of diazepam as hypnotic drug on blood pressure (BP) and heart rate (HR) in healthy elderly subjects. PATIENTS AND METHODS: Healthy, elderly subjects, aged 65-74 years, were treated with diazepam 5 mg or placebo-both administered once a day in the evening-for 4 weeks in two cross-over periods, each separated by a 2-week placebo period, according to a randomized, double-blind, cross-over design...
June 29, 2018: Aging Clinical and Experimental Research
Izaro Esain, Susana M Gil, Iraia Bidaurrazaga-Letona, Ana Rodriguez-Larrad
BACKGROUND: Little is known about the effects of detraining in older adults, particularly those who regularly exercise. AIMS: To determine the consequences of 3 months of cessation of a habitual supervised exercise on functional fitness and quality of life in aged adults and to explore the associations among those parameters. METHODS: Thirty-eight women and 11 men (mean age 75.5 ± 5.7 years) took part in a physical exercise program for 9 months, followed by a 3-month detraining period...
June 29, 2018: Aging Clinical and Experimental Research
Carlo Biz, Jacopo Tagliapietra, Andrea Angelini, Elisa Belluzzi, Assunta Pozzuoli, Antonio Berizzi, Pietro Ruggieri
No abstract text is available yet for this article.
June 27, 2018: Aging Clinical and Experimental Research
A Tasatargil, G Tanriover, A Barutcigil, E Turkmen
BACKGROUND: The cardiovascular benefits of resveratrol (RSV) have been well established by previous experimental and clinical studies. The aim of this study was to investigate the effectiveness of RSV administration on the impaired endothelial function induced by methylglyoxal (MGO), and to elucidate the role of endothelial nitric oxide synthase (eNOS) on its protective effect. METHODS: Aged Wistar rats (80 weeks old, n = 15) were used in this study. The thoracic aorta was isolated and cut into rings for organ culture...
June 27, 2018: Aging Clinical and Experimental Research
Giorgio Basile, Antonino Catalano, Giuseppe Mandraffino, Giuseppe Maltese, Angela Alibrandi, Giuliana Ciancio, Daniela Brischetto, Nunziata Morabito, Antonino Lasco, Matteo Cesari
BACKGROUND: Frailty is a predictor of adverse outcomes in older subjects. AIMS: The aims of this study are to (1) measure the frailty status and its changes occurring during the hospital stay, (2) determine the relationships among frailty and adverse outcomes. METHODS: Frailty was assessed using a 46-item Frailty Index (FI) in 156 patients admitted to an Acute Geriatric Medicine Unit. The FI was calculated within 24 h from the hospital admission (aFI) and at his/her discharge (dFI)...
June 26, 2018: Aging Clinical and Experimental Research
Seung-Hyun Boo, Min Cheol Joo, Jeong Mi Lee, Seung Chan Kim, Young Mi Yu, Min-Su Kim
BACKGROUND: Sarcopenia reduces physical ability and cardiorespiratory fitness (CRF), leading to poor quality of life. AIM: The aim of this study was to investigate the relationship between skeletal muscle mass and CRF in elderly men. METHODS: We assessed 102 community-dwelling men over 60 years old. Appendicular skeletal muscle mass (ASM) was determined using bioelectrical impedance analysis, and the skeletal muscle mass index (SMI) was calculated as ASM divided by the square of height...
June 18, 2018: Aging Clinical and Experimental Research
Maurits F J Vandewoude, Janneke P van Wijngaarden, Lieven De Maesschalck, Yvette C Luiking, André Van Gossum
In the original publication, table row alignment was incorrectly formatted for all the tables. The corrected tables are given below.
June 12, 2018: Aging Clinical and Experimental Research
E Disegna, A De Caro, N Nori, M Taylor, F Fantin, G Mazzali, E Zoico, S Marchiotto, M Zamboni, S Gattazzo, A P Rossi
No abstract text is available yet for this article.
June 11, 2018: Aging Clinical and Experimental Research
Giulio Pioli, Chiara Bendini, Andrea Giusti, Paolo Pignedoli, Michele Cappa, Enrico Iotti, Maria Alice Ferri, Eleonora Bergonzini, Ettore Sabetta
AIM: To investigate the relationship between onset of delirium and time to surgery in hip fracture (HF) patients with a different degree of cognitive impairment. METHODS: Retrospective analysis of a prospective database of 939 older adults, aged ≥ 75 years admitted with a fragility HF. Subjects underwent a Comprehensive Geriatric Assessment on admission, evaluating health status, prefracture functional status in basic and instrumental activities of daily living, and walking ability...
June 8, 2018: Aging Clinical and Experimental Research
Alessandro Iavarone, Michele Carpinelli Mazzi, Gennaro Russo, Francesco D'Anna, Silvio Peluso, Pietro Mazzeo, Vincenzo De Luca, Giuseppe De Michele, Guido Iaccarino, Pasquale Abete, Graziella Milan, Elisabetta Garofalo, Caterina Musella, Rónán O'Caoimh, William Molloy, Gabriella De Joanna, Valentino Manzo, Ferdinando Ivano Ambra, Alfredo Postiglione, Maddalena Illario
OBJECTIVE: To devise an Italian version of the quick mild cognitive impairment screen (Qmci) and to obtain normative data. METHODS: An Italian version of the Qmci screen (Qmci-I) was administered to 307 subjects free from cognitive impairment. The normative sample was divided into three age levels (50-59; 60-69 and 70-80 years) and four education levels (3-5; 6-8; 9-13; >13 years of school attendance). Multiple regression analyses were used to evaluate the effect of age, sex and schooling on Qmci-I scores (overall and by domains) and to calculate cut-off values, with reference to the confidence interval on the fifth centile...
June 8, 2018: Aging Clinical and Experimental Research
Mathieu Maltais, Yves Rolland, Paul-Emile Haÿ, Didier Armaingaud, Bruno Vellas, Philipe de Souto Barreto
BACKGROUND: Studies have demonstrated changes in activities of daily living after an exercise intervention in people with dementia (PWD) living in nursing homes (NH). However, some discrepancies are shown during follow-up. AIMS: Our objective was to measure activities of daily living (ADL) performance during a 6-month observational follow-up after a 6-month exercise or social activity intervention in PWD living in NH. METHODS: After cluster randomisation, 91 PWD living in NH performed a 6-month structured exercise intervention (n = 44) or a social activity intervention (n = 47)...
June 7, 2018: Aging Clinical and Experimental Research
Alberto Castagna, Pietro Gareri, Francesca Falvo, Simona Sestito, Maurizio Rocca, Licia Pensabene, Daniela Concolino, Giuseppe Coppolino, Giovanni Ruotolo
No abstract text is available yet for this article.
June 6, 2018: Aging Clinical and Experimental Research
Noelia Gómez-Aguirre, Daniel Fuertes-Ruiz, Borja Gracia-Tello, Carolina Clemente-Sarasa, Ester Artajona-Rodrigo, José-Luis Cabrerizo-García, Begoña de Escalante-Yangüela, María-Carmen Bueno-Castel, José Velilla-Marco, Jesús Díez-Manglano
OBJECTIVE: To externally validate the PALIAR index for patients with advanced, nononcologic chronic diseases. METHODS: We performed a prospective, multicenter cohort study that included patients with advanced, nononcologic chronic diseases hospitalized in internal medicine departments and treated consecutively by the researchers between July 1st and December 31st, 2014. Data were collected from each patient on age, sex, advanced disease, Charlson index, comorbidities, Barthel index, terminal illness symptoms, need for caregiver, hospitalization in the past 3 and 12 months and number of drugs...
June 6, 2018: Aging Clinical and Experimental Research
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