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Aging Clinical and Experimental Research

Natalie Richer, Yves Lajoie
BACKGROUND: The interstimulus interval of a cognitive task was found to have a limited effect on postural control in young adults, while visual cognitive tasks were found to improve stability compared to auditory tasks. It is of interest to investigate whether postural control in healthy older adults is sensitive to these types of cognitive task manipulations. AIMS: The objectives of the present experiment were to evaluate the impact of interstimulus interval and modality of a continuous cognitive task on postural control in healthy older adults...
November 9, 2018: Aging Clinical and Experimental Research
Anke Bahrmann, Laura Benner, Michael Christ, Thomas Bertsch, Cornel C Sieber, Hugo Katus, Philipp Bahrmann
BACKGROUND AND AIMS: The Charlson Comorbidity Index (CCI) is the most widely used assessment tool to report the presence of comorbid conditions. The Barthel index (BI) is used to measure performance in activities of daily living. We prospectively investigated the performance of CCI or BI to predict length of hospital stay (LOS), mortality, cardiovascular (CV) mortality and rehospitalization in unselected older patients on admission to the emergency department (ED). We also studied the association of CCI or BI with costs...
November 8, 2018: Aging Clinical and Experimental Research
Yuriko Komagamine, Manabu Kanazawa, Ayako Yamada, Shunsuke Minakuchi
BACKGROUND: Masticatory performance of elderly complete denture wearers is low, which may lead to restriction on intakes of several foods such as fresh fruit or raw vegetables. AIM: The aim of this study was to investigate the relationship between tongue motor function, lip motor function, and mixing ability in complete denture wearers. MATERIALS AND METHODS: Participants comprised 54 complete denture wearers with a mean age of 77.1 years...
November 8, 2018: Aging Clinical and Experimental Research
Yan-Bin Chen
Pulmonary hypertension (PH) is a very common kind of pulmonary vascular disease, which can cause a heavier burden on patient's quality of life, even lead to death. Yet, the mechanism of PH is incomprehensive and not so clear nowadays. In recent years, more and more studies show that autophagy plays a pivotal role in the development of PH. Some modalities target on the formation or maturation of autophagosome that has emerged from our increasing knowledge of autophagy machinery, which may prevent or eliminate the process of PH...
November 8, 2018: Aging Clinical and Experimental Research
Ute Hoffmann, Michael Drey, Jan-Marc Thrun, Elsa Obermeier, Christian Weingart, Katharina Hafner, Cornel Sieber
BACKGROUND: Arterial hypertension is a common condition in older adults with increasing data about blood pressure (BP) targets and antihypertensive treatment in this population. Recent studies have opened new discussions about the different usual and unusual methods of blood pressure monitoring. However, there are no evidence-based recommendations whether BP should be measured at upper arms or at wrist, which seems to be more comfortable in older and frail people. AIMS: The purpose of this study was to test the quality of wrist BP monitors as diagnostic method in older adults...
November 8, 2018: Aging Clinical and Experimental Research
Emin Altintas, Karim Gallouj, Mohamad El Haj
BACKGROUND AND AIMS: This study investigated the ability of older adults to shift between self-images. METHODS: We designed a shifting-self task in which older adults and younger adults were invited to produce statements describing their physical self (e.g., "I am tall") and psychological self (e.g., "I am cheerful"). Participants were invited to shift between physical-self statements and psychological-self statements and, on a control task, to produce two blocks of physical-self statements and psychological-self statements...
November 7, 2018: Aging Clinical and Experimental Research
Phoebe Ullrich, Christian Werner, Tobias Eckert, Martin Bongartz, Rainer Kiss, Manuel Feißt, Kim Delbaere, Jürgen M Bauer, Klaus Hauer
BACKGROUND: A version of the Life-Space Assessment in persons with cognitive impairment (LSA-CI) has recently been developed. AIMS: To establish a cut-off value for the newly developed Life-Space Assessment in persons with cognitive impairment (LSA-CI). METHODS: In a cross-sectional study including 118 multimorbid, older persons with cognitive impairment, life-space mobility (LSM) was documented by the LSA-CI. The analysis was rationalized by Global Positioning System (GPS)-based measures of spatial distance from home...
November 7, 2018: Aging Clinical and Experimental Research
Walter Verrusio, Valerio Massimo Magro, Alessia Renzi, Bruno Casciaro, Paola Andreozzi, Mauro Cacciafesta
AIM: To explore the relationship between thyroid hormones, Vitamin D (Vit.D) serum concentrations and metabolic syndrome (MetS) in euthyroid subjects. METHODS: 123 community-dwelling subjects were enrolled. According to thyroid-stimulating hormone (TSH) values the sample was divided into: (1) group 1 (TSH ≤ 2 mU/L); (2) group 2 (TSH > 2 mU/L). RESULTS: Group 2 showed higher percentage of subjects with MetS (p = 0.003) and hypertension (p = 0...
November 7, 2018: Aging Clinical and Experimental Research
Kristina L Bailey, Lynette M Smith, Art J Heires, Dawn M Katafiasz, Debra J Romberger, Tricia D LeVan
BACKGROUND: Sepsis is more common in the elderly. TNF⍺ is recognized as an important mediator in sepsis and Toll-like receptors (TLRs) play an important role in initiating signaling cascades to produce TNF⍺. Little is known about how innate immunity is altered in healthy human aging that predisposes to sepsis. AIMS AND METHODS: We tested the hypothesis that aging dysregulates the innate immune response to TLR 2 and 4 ligands. We performed whole blood assays on 554 healthy subjects aged 40-80 years...
November 7, 2018: Aging Clinical and Experimental Research
Marco Di Monaco, Carlotta Castiglioni, Edoardo Milano, Giuseppe Massazza
BACKGROUND AND AIMS: Subjects with osteosarcopenia, the concurrent presence of sarcopenia and osteoporosis, have prognostic disadvantages and can benefit from treatments targeted at both the conditions. Our aim was to elucidate whether the available definitions of low appendicular lean mass (aLM) capture or not the men with associated low bone mineral density (BMD) following a hip fracture. METHODS: 80 men admitted to our rehabilitation hospital underwent a dual-energy X-ray absorptiometry scan 19...
November 7, 2018: Aging Clinical and Experimental Research
Pasquale Morella, Maurizio Sacco, Mariano Carafa, Gaetana Ferro, Francesco Curcio, Gaetano Gargiulo, Gianluca Testa, Ilaria Liguori, Gennaro Russo, Francesco Cacciatore, Carlo Gabriele Tocchetti, Domenico Bonaduce, Pasquale Abete
BACKGROUND AND AIM: Permanent Atrial Fibrillation (pAF) is associated with increased risk of embolic complications. The relationship between pAF and pulmonary embolism (PE) has not been extensively investigated in elderly patients. Here, we aim at verifying whether pAF is associated to an increased risk of PE in a cohort of elderly patients with and without Deep Vein Thrombosis (DVT). METHODS: 235 patients older than 65 years with PE with or without pAF were retrospectively enrolled and stratified by the absence or presence of DVT...
October 29, 2018: Aging Clinical and Experimental Research
Yunlu Sheng, Dan Ma, Qi Zhou, Li Wang, Minne Sun, Siting Wang, Hanmei Qi, Jin Liu, Guoxian Ding, Yu Duan
OBJECTIVES: With the increase in aging population worldwide, the incidence of sarcopenia is also increasing. Thyroid hormones are important regulators that can affect body composition and physical function. The association between thyroid hormone levels and sarcopenia in susceptible elderly euthyroid subjects remains unclear. In this study, we investigated the effect of thyroid hormone concentrations on body muscle mass, muscle strength and physical function related to sarcopenia in elderly Chinese euthyroid subjects...
October 26, 2018: Aging Clinical and Experimental Research
Taylor Leeder, Farahnaz Fallahtafti, Molly Schieber, Sara A Myers, Julie Blaskewicz Boron, Jennifer M Yentes
BACKGROUND: Dual-task paradigms are used to investigate gait and cognitive declines in older adults (OA). Optic-flow is a virtual reality environment where the scene flows past the subject while walking on a treadmill, mimicking real-life locomotion. AIMS: To investigate cost of environment (no optic-flow v. optic-flow) while completing single- and dual-task walking and dual-task costs (DTC; single- v. dual-task) in optic-flow and no optic-flow environments. METHODS: Twenty OA and seven younger adults (YA) walked on a self-paced treadmill in 3-min segments per task and both environments...
October 26, 2018: Aging Clinical and Experimental Research
Saurja Thapa, Robert H Shmerling, Jonathan F Bean, Yurun Cai, Suzanne G Leveille
BACKGROUND: Chronic musculoskeletal pain is highly prevalent in the older adults, and individuals with musculoskeletal pain frequently report pain in two or more sites. AIMS: To determine the prevalence and characteristics of multisite pain in relation to other geriatric syndromes and to evaluate whether multisite pain may represent a distinct geriatric syndrome. METHODS: The MOBILIZE Boston Study is a population-based cohort study of older adults that enrolled 749 participants aged 70 and older...
October 25, 2018: Aging Clinical and Experimental Research
Gaëlle Soriano, Philippe Souto De Barreto, Yves Rolland, Marie Plessz, Sabine Goisser, Sophie Guyonnet, Bertrand Fougère, Bruno Vellas, Sandrine Andrieu, Sandrine Sourdet
OBJECTIVE: To investigate ready-meal consumption trends in older French people, its association with overall diet quality and obesity. DESIGN: Cross-sectional analysis SETTING: Multidomain Alzheimer Preventive Trial (MAPT), France SUBJECTS: 421 MAPT participants (mean age 76.8 years) who filled a food frequency questionnaire. RESULTS: The frequency of ready-meal consumption was low, with nearly 90% of participants declaring consuming ≤ 1 ready-meal per week...
October 23, 2018: Aging Clinical and Experimental Research
Sungyoup Hong, Woon Jeong Lee, Dae Hee Kim, Seung Hwan Seol, June Young Lee, Sang Kook In, Hye Won Lee, Seon Hee Woo, Jung Hee Wee
PURPOSE: Many elderly patients arrive at the emergency department (ED) complaining of deliberate self-poisoning (DSP). This study determined the poisoning severity of elderly patients who committed DSP. METHODS: A study was performed with 1329 patients (> 15 years of age) who were treated for DSP at two EDs between January 2010 and December 2016. We classified these patients into two groups based on age (an elderly group ≥ 65 years of age and a nonelderly group)...
October 22, 2018: Aging Clinical and Experimental Research
Ines Pintado Maury, Mariana Alves, Teresa Fonseca
INTRODUCTION: Syphilis is a systemic human disease which is caused by infection with the spirochete Treponema pallidum. It is spread worldwide, and there has recently been an increase in its incidence. Neurosyphilis (NS) can have a variety of presentations; meningovascular NS is a specific affection of the Treponema which occurs in an early stage after the primary infection, causing an inflammatory arteriopathy which may result in an ischemic stroke. As a rare manifestation of syphilis, there are few prevalence and epidemiological studies, and data are almost non-existent...
October 20, 2018: Aging Clinical and Experimental Research
Pierpaolo Palumbo, Clemens Becker, Stefania Bandinelli, Lorenzo Chiari
BACKGROUND: The current guidelines for fall prevention in community-dwelling older adults issued by the American Geriatrics Society and British Geriatrics Society (AGS/BGS) indicate an algorithm for identifying who is at increased risk of falling. The predictive accuracy of this algorithm has never been assessed, nor have the consequences that its introduction in clinical practice would bring about. AIMS: To evaluate this risk screening algorithm, estimating its predictive accuracy and its potential impact...
October 19, 2018: Aging Clinical and Experimental Research
Björn Westerlind, Carl Johan Östgren, Sigvard Mölstad, Patrik Midlöv, Staffan Hägg
BACKGROUND: Falls and related injuries are common among older people, and several drug classes are considered to increase fall risk. AIMS: This study aimed to investigate the association between the use of certain drug classes and falls in older nursing home residents in Sweden, and relate these to different age groups. METHODS: Information on falls that occurred in the previous year and regular use of possible fall risk drugs including non-benzodiazepine hypnotics (zopiclone and zolpidem) was collected from 331 nursing home residents during 2008-2011...
October 19, 2018: Aging Clinical and Experimental Research
Ilknur Sanli, Sven H van Helden, René H M Ten Broeke, Piet Geusens, Joop P W Van den Bergh, Peter R G Brink, Martijn Poeze
BACKGROUND: Several guidelines recommend a bone and fall-related osteoporosis risk assessment in all patients with fracture and age > 50 years. In practice, however, there is no consensus whether screening > 85 years is useful. AIM: To evaluate the subsequent fracture risk in all patient > 85 years, comparing the two populations of Fracture Liaison Service (FLS) attenders and non-attenders. METHODS: All patients > 85 years that presented at the FLS with a non-vertebral fracture were included in the study during a 5-year period (September 2004 and December 2009)...
October 11, 2018: Aging Clinical and Experimental Research
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