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International Journal of MS Care

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https://www.readbyqxmd.com/read/28603466/editorial
#1
EDITORIAL
Francois Bethoux
No abstract text is available yet for this article.
May 2017: International Journal of MS Care
https://www.readbyqxmd.com/read/28603465/spinal-cord-as-an-adjunct-to-brain-magnetic-resonance-imaging-in-defining-no-evidence-of-disease-activity-in-multiple-sclerosis
#2
Subhash Tummala, Tarun Singhal, Vinit V Oommen, Gloria Kim, Fariha Khalid, Brian C Healy, Rohit Bakshi
Background: Monitoring patients with multiple sclerosis (MS) for “no evidence of disease activity” (NEDA) may help guide disease-modifying therapy (DMT) management decisions. Whereas surveillance brain magnetic resonance imaging (MRI) is common, the role of spinal cord monitoring for NEDA is unknown. Objective: To evaluate the role of brain and spinal cord 3T MRI in the 1-year evaluation of NEDA. Methods: Of 61 study patients (3 clinically isolated syndrome, 56 relapsing-remitting, 2 secondary progressive), 56 (91...
May 2017: International Journal of MS Care
https://www.readbyqxmd.com/read/28603464/reliability-and-validity-of-the-computerized-dynamic-posturography-sensory-organization-test-in-people-with-multiple-sclerosis
#3
Jeffrey R Hebert, Mark M Manago
BACKGROUND: People with multiple sclerosis (MS) frequently have impaired postural control (balance). Psychometric properties of clinical tests of balance for individuals with MS, including the computerized dynamic posturography sensory organization test (CDP-SOT), are poorly understood. This study aimed to determine the reliability and discriminant validity of the CDP-SOT in people with MS. METHODS: The CDP-SOT was performed on 30 participants with MS. A 2-week-interval, repeated-measures (sessions 1 and 2) design was implemented to investigate test-retest reliability of the CDP-SOT and the ability of the CDP-SOT to discriminate between participants with lower versus higher disability...
May 2017: International Journal of MS Care
https://www.readbyqxmd.com/read/28603463/case-report-two-cases-of-nicolau-syndrome-associated-with-glatiramer-acetate
#4
Dorlan J Kimbrough, Scott D Newsome
We report two cases of Nicolau syndrome (embolia cutis medicamentosa), a rare complication of injectable medications, both associated with the administration of 20 mg of subcutaneous glatiramer acetate. Both patients required surgical debridement and were subsequently treated conservatively without additional complications. Patient 1 opted to discontinue disease-modifying therapy. Patient 2 continued glatiramer acetate therapy without complications by using other injection sites. These cases highlight the need for prompt investigation of new unusual skin lesions in patients receiving injectable multiple sclerosis treatments (regardless of length of treatment and previous minor cosmetic concerns) and illustrate the clinical distinction between Nicolau syndrome and drug-induced skin necrosis...
May 2017: International Journal of MS Care
https://www.readbyqxmd.com/read/28603462/immune-response-to-seasonal-influenza-vaccine-in-patients-with-relapsing-remitting-multiple-sclerosis-receiving-long-term-daclizumab-beta-a-prospective-open-label-single-arm-study
#5
Lahar Mehta, Kimberly Umans, Gulden Ozen, Randy R Robinson, Jacob Elkins
BACKGROUND: For patients with relapsing-remitting multiple sclerosis (RRMS) undergoing continuous immunomodulatory therapy, understanding whether vaccinations can be performed safely and effectively is important. We tested the immune response to inactivated seasonal influenza vaccine during long-term daclizumab beta treatment. METHODS: In this prospective, open-label, single-arm extension SELECTED study, an optional vaccine substudy was performed on patients with RRMS who had already received daclizumab beta for 1 to 2 years in previous studies...
May 2017: International Journal of MS Care
https://www.readbyqxmd.com/read/28603461/perceptions-of-multiple-sclerosis-in-hispanic-americans-need-for-targeted-messaging
#6
Ozioma Obiwuru, Sarah Joseph, Lihua Liu, Ana Palomeque, Leslie Tarlow, Annette M Langer-Gould, Lilyana Amezcua
BACKGROUND: Illness perceptions have been reported to be important determinants of multiple sclerosis (MS)-related well-being. Hispanic culture is defined by strong cultural beliefs in which illness is often perceived to arise from strong emotions. Understanding the perceptions of MS in Hispanic Americans may provide a better understanding of cultural barriers that may exist. The purpose of this study was to describe Hispanic American perceptions of MS. METHODS: We gathered information from semistructured interviews, focus groups, and participant responses from the University of Southern California Hispanic MS Registry...
May 2017: International Journal of MS Care
https://www.readbyqxmd.com/read/28603460/cultivating-the-multiple-sclerosis-workforce-of-the-future
#7
Gabriele C DeLuca, Guy Buckle, Irene Cortese, Jennifer S Graves, June Halper, Scott D Newsome, Nancy Sicotte, Corey C Ford
Multiple sclerosis (MS) is a complex neurologic disorder that affects people with ever-changing needs. The MS health-care field has entered an era of exponential knowledge growth in which better understanding of the immunologic dysregulation of the disease has translated into an expanding array of treatment options. It is estimated that, if it has not already, within the next decade the demands of a growing MS patient population will outstrip the number of professionals dedicated to the management of this chronic, lifelong disease...
May 2017: International Journal of MS Care
https://www.readbyqxmd.com/read/28603459/outcomes-after-functional-electrical-stimulation-cycle-training-in-individuals-with-multiple-sclerosis-who-are-nonambulatory
#8
Deborah Backus, Blake Burdett, Laura Hawkins, Christine Manella, Kevin K McCully, Mark Sweatman
BACKGROUND: Exercise is safe and beneficial for people with multiple sclerosis (MS). Functional electrical stimulation (FES) cycling offers people with significant weakness and mobility challenges an option for exercise. We sought to evaluate the safety of FES cycling and its potential to improve fatigue, pain, spasticity, and quality of life in people with moderate-to-severe MS. METHODS: Sixteen participants with MS who were nonambulatory cycled for 30 minutes two to three times a week for 1 month...
May 2017: International Journal of MS Care
https://www.readbyqxmd.com/read/28243187/editorial
#9
Francois Bethoux
No abstract text is available yet for this article.
January 2017: International Journal of MS Care
https://www.readbyqxmd.com/read/28243186/a-framework-of-care-in-multiple-sclerosis-part-2-symptomatic-care-and-beyond
#10
Scott D Newsome, Philip J Aliotta, Jacquelyn Bainbridge, Susan E Bennett, Gary Cutter, Kaylan Fenton, Fred Lublin, Dorothy Northrop, David Rintell, Bryan D Walker, Megan Weigel, Kathleen Zackowski, David E Jones
The Consortium of Multiple Sclerosis Centers (CMSC) convened a Framework Taskforce composed of a multidisciplinary group of clinicians and researchers to examine and evaluate the current models of care in multiple sclerosis (MS). The methodology of this project included analysis of a needs assessment survey and an extensive literature review. The outcome of this work is a two-part continuing education series of articles. Part 1, published previously, covered the updated disease phenotypes of MS along with recommendations for the use of disease-modifying therapies...
January 2017: International Journal of MS Care
https://www.readbyqxmd.com/read/28243185/immediate-effect-of-a-service-dog-on-walking-speed-in-individuals-with-multiple-sclerosis-and-gait-dysfunction-a-pilot-study
#11
Cecilie Fjeldstad, Gabriel Pardo
No abstract text is available yet for this article.
January 2017: International Journal of MS Care
https://www.readbyqxmd.com/read/28243184/feasibility-and-impact-of-an-8-week-integrative-yoga-program-in-people-with-moderate-multiple-sclerosis-related-disability-a-pilot-study
#12
Evan T Cohen, David Kietrys, Susan Gould Fogerite, Mariella Silva, Kristen Logan, Donald A Barone, J Scott Parrott
BACKGROUND: This pilot study determined the feasibility of a specifically designed 8-week yoga program for people with moderate multiple sclerosis (MS)-related disability. We explored the program's effect on quality of life (QOL) and physical and mental performance. METHODS: We used a single-group design with repeated measurements at baseline, postintervention, and 8-week follow-up. Feasibility was examined through cost, recruitment, retention, attendance, and safety...
January 2017: International Journal of MS Care
https://www.readbyqxmd.com/read/28243183/multidisciplinary-management-of-sexual-dysfunction-perineal-pain-and-elimination-dysfunction-in-a-woman-with-multiple-sclerosis
#13
Michela Miletta, Fabrizio Bogliatto, Leonardo Bacchio
BACKGROUND: Multiple sclerosis (MS) is a chronic disease that commonly affects young women and is associated with sexual dysfunction (SD) and lower anourogenital dysfunction, which affect quality of life. We evaluated the importance of an integrated multidisciplinary approach in the Lower Female Ano-Uro-Genital Network (LFAUGN) to manage a variety of complex symptoms. METHODS: A 40-year-old woman with MS and primary concerns about perineal pain and SD was treated by a trained midwife from the LFAUGN and a physical therapist after a multidisciplinary diagnostic process that included gynecologic evaluation for perineal pain and SD, physiatric assessment, urologic assessment for bladder retention (BR), and surgical examination for obstructed defecation syndrome (ODS)...
January 2017: International Journal of MS Care
https://www.readbyqxmd.com/read/28243182/laquinimod-safety-profile-pooled-analyses-from-the-allegro-and-bravo-trials
#14
Per Soelberg Sørensen, Giancarlo Comi, Timothy L Vollmer, Xavier Montalban, Ludwig Kappos, Yuval Dadon, Tali Gorfine, Maya Margalit, Nissim Sasson, Svetlana Rubinchick, Volker Knappertz
BACKGROUND: Laquinimod 0.6 mg is a once-daily, oral, disease-modifying therapy in development for the treatment of multiple sclerosis (MS) that was investigated in two double-blind, placebo-controlled, phase 3 trials: ALLEGRO and BRAVO. METHODS: Data from these studies were pooled to assess the safety profile of laquinimod versus placebo. Adverse events (AEs), laboratory value changes, and potential risks identified in preclinical studies were evaluated in participants in ALLEGRO and BRAVO treated with at least one dose of laquinimod or matching placebo (1:1 random assignment)...
January 2017: International Journal of MS Care
https://www.readbyqxmd.com/read/28243181/stopping-disease-modifying-therapy-in-nonrelapsing-multiple-sclerosis-experience-from-a-clinical-practice
#15
Gary Birnbaum
BACKGROUND: Current disease-modifying therapies (DMTs) are of benefit only in people with relapsing forms of multiple sclerosis (RMS). Thus, safely stopping DMTs in people with secondary progressive MS may be possible. METHODS: Two groups of patients with MS were studied. Group A consisted of 77 patients with secondary progressive MS and no evidence of acute central nervous system inflammation for 2 to 20 years. These patients were advised to stop DMTs. Group B consisted of 17 individuals with RMS who stopped DMTs on their own...
January 2017: International Journal of MS Care
https://www.readbyqxmd.com/read/28243180/screening-instruments-for-the-early-detection-of-cognitive-impairment-in-patients-with-multiple-sclerosis
#16
Sonya Kim, Vance Zemon, Joseph F Rath, MaryAnn Picone, Elizabeth S Gromisch, Heather Glubo, Lucia Smith-Wexler, Frederick W Foley
BACKGROUND: Cognitive impairments are common in individuals with MS and adversely affect functioning. Early detection of cognitive impairment, therefore, would enable earlier, and possibly more effective, treatment. We sought to compare self-reports with a short neuropsychological test as possible screening tools for cognitive impairment. METHODS: One hundred patients with MS were tested with the Minimal Assessment of Cognitive Function in Multiple Sclerosis; z scores were used to derive the Cognitive Index (CI)...
January 2017: International Journal of MS Care
https://www.readbyqxmd.com/read/27999526/cme-cne-article-a-framework-of-care-in-multiple-sclerosis-part-1-updated-disease-classification-and-disease-modifying-therapy-use-in-specific-circumstances
#17
Scott D Newsome, Philip J Aliotta, Jacquelyn Bainbridge, Susan E Bennett, Gary Cutter, Kaylan Fenton, Fred Lublin, Dorothy Northrop, David Rintell, Bryan D Walker, Megan Weigel, Kathleen Zackowski, David E Jones
Activity Available Online: To access the article, post-test, and evaluation online, go to http://www.cmscscholar.org. TARGET AUDIENCE: The target audience for this activity is physicians, physician assistants, nursing professionals, and other health-care providers involved in the management of patients with multiple sclerosis (MS). LEARNING OBJECTIVES: Apply new information about MS to a comprehensive individualized treatment plan for patients with MSIntegrate the team approach into long-term planning in order to optimize rehabilitation care of patients with MSAccreditation Statement: This activity has been planned and implemented in accordance with the accreditation requirements and policies of the Accreditation Council for Continuing Medical Education (ACCME) through the joint providership of the Consortium of Multiple Sclerosis Centers (CMSC), Nurse Practitioner Alternatives (NPA), and Delaware Media Group...
November 2016: International Journal of MS Care
https://www.readbyqxmd.com/read/27999525/antidepressant-drug-treatment-in-association-with-multiple-sclerosis-disease-modifying-therapy-using-explorys-in-the-ms-population
#18
Matthew M Mirsky, Ruth Ann Marrie, Alexander Rae-Grant
Background: The Explorys Enterprise Performance Management (EPM) database contains de-identified clinical data for 50 million patients. Multiple sclerosis (MS) disease-modifying therapies (DMTs), specifically interferon beta (IFNβ) treatments, may potentiate depression. Conflicting data have emerged, and a large-scale claims-based study by Patten et al. did not support such an association. This study compares the results of Patten et al. with those using the EPM database. Methods: "Power searches" were built to test the relationship between antidepressant drug use and DMT in the MS population...
November 2016: International Journal of MS Care
https://www.readbyqxmd.com/read/27999524/individual-and-co-occurring-snap-risk-factors-smoking-nutrition-alcohol-consumption-and-physical-activity-in-people-with-multiple-sclerosis
#19
Julia M Balto, Ipek Ensari, Elizabeth A Hubbard, Naiman Khan, Jennifer L Barnes, Robert W Motl
Background: Smoking, poor nutrition, excess alcohol consumption, and insufficient physical activity underlie most preventable causes of morbidity in the general population and may be associated with comorbidities and health outcomes in multiple sclerosis (MS). However, the frequency of co-occurrence of these risk factors in people with MS remains unclear. Methods: Sixty-nine individuals with MS completed self-report measures of smoking status, nutrition, alcohol use, physical activity levels, and sociodemographic and clinical characteristics...
November 2016: International Journal of MS Care
https://www.readbyqxmd.com/read/27999523/assessment-and-treatment-of-psychiatric-distress-sexual-dysfunction-sleep-disturbances-and-pain-in-multiple-sclerosis-a-survey-of-members-of-the-consortium-of-multiple-sclerosis-centers
#20
Elizabeth S Gromisch, Laura C Schairer, Eliana Pasternak, Stella H Kim, Frederick W Foley
Background: Psychiatric distress (depression and anxiety), sexual dysfunction, sleep disturbances, and pain are frequent comorbidities in multiple sclerosis (MS) that have the potential to interfere with functioning and quality of life. Often, patients benefit from a combination of medical and psychotherapeutic interventions. However, the literature suggests that many of these issues have been underdiagnosed or undertreated. To better understand current practices, this study aimed to gain a multidisciplinary perspective on how MS providers assess and treat these five problems...
November 2016: International Journal of MS Care
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