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International Journal of MS Care

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https://www.readbyqxmd.com/read/27999526/cme-cne-article-a-framework-of-care-in-multiple-sclerosis-part-1-updated-disease-classification-and-disease-modifying-therapy-use-in-specific-circumstances
#1
Scott D Newsome, Philip J Aliotta, Jacquelyn Bainbridge, Susan E Bennett, Gary Cutter, Kaylan Fenton, Fred Lublin, Dorothy Northrop, David Rintell, Bryan D Walker, Megan Weigel, Kathleen Zackowski, David E Jones
: Activity Available Online: To access the article, post-test, and evaluation online, go to http://www.cmscscholar.org. TARGET AUDIENCE: The target audience for this activity is physicians, physician assistants, nursing professionals, and other health-care providers involved in the management of patients with multiple sclerosis (MS). LEARNING OBJECTIVES: Apply new information about MS to a comprehensive individualized treatment plan for patients with MSIntegrate the team approach into long-term planning in order to optimize rehabilitation care of patients with MSAccreditation Statement: This activity has been planned and implemented in accordance with the accreditation requirements and policies of the Accreditation Council for Continuing Medical Education (ACCME) through the joint providership of the Consortium of Multiple Sclerosis Centers (CMSC), Nurse Practitioner Alternatives (NPA), and Delaware Media Group...
November 2016: International Journal of MS Care
https://www.readbyqxmd.com/read/27999525/antidepressant-drug-treatment-in-association-with-multiple-sclerosis-disease-modifying-therapy-using-explorys-in-the-ms-population
#2
Matthew M Mirsky, Ruth Ann Marrie, Alexander Rae-Grant
Background: The Explorys Enterprise Performance Management (EPM) database contains de-identified clinical data for 50 million patients. Multiple sclerosis (MS) disease-modifying therapies (DMTs), specifically interferon beta (IFNβ) treatments, may potentiate depression. Conflicting data have emerged, and a large-scale claims-based study by Patten et al. did not support such an association. This study compares the results of Patten et al. with those using the EPM database. Methods: "Power searches" were built to test the relationship between antidepressant drug use and DMT in the MS population...
November 2016: International Journal of MS Care
https://www.readbyqxmd.com/read/27999524/individual-and-co-occurring-snap-risk-factors-smoking-nutrition-alcohol-consumption-and-physical-activity-in-people-with-multiple-sclerosis
#3
Julia M Balto, Ipek Ensari, Elizabeth A Hubbard, Naiman Khan, Jennifer L Barnes, Robert W Motl
Background: Smoking, poor nutrition, excess alcohol consumption, and insufficient physical activity underlie most preventable causes of morbidity in the general population and may be associated with comorbidities and health outcomes in multiple sclerosis (MS). However, the frequency of co-occurrence of these risk factors in people with MS remains unclear. Methods: Sixty-nine individuals with MS completed self-report measures of smoking status, nutrition, alcohol use, physical activity levels, and sociodemographic and clinical characteristics...
November 2016: International Journal of MS Care
https://www.readbyqxmd.com/read/27999523/assessment-and-treatment-of-psychiatric-distress-sexual-dysfunction-sleep-disturbances-and-pain-in-multiple-sclerosis-a-survey-of-members-of-the-consortium-of-multiple-sclerosis-centers
#4
Elizabeth S Gromisch, Laura C Schairer, Eliana Pasternak, Stella H Kim, Frederick W Foley
Background: Psychiatric distress (depression and anxiety), sexual dysfunction, sleep disturbances, and pain are frequent comorbidities in multiple sclerosis (MS) that have the potential to interfere with functioning and quality of life. Often, patients benefit from a combination of medical and psychotherapeutic interventions. However, the literature suggests that many of these issues have been underdiagnosed or undertreated. To better understand current practices, this study aimed to gain a multidisciplinary perspective on how MS providers assess and treat these five problems...
November 2016: International Journal of MS Care
https://www.readbyqxmd.com/read/27999522/effect-of-comorbidities-on-outcomes-of-neurorehabilitation-interventions-in-multiple-sclerosis-a-scoping-review
#5
Afolasade Fakolade, Etienne J Bisson, Julie Pétrin, Julie Lamarre, Marcia Finlayson
Background: Interest in comorbidities has increased in the past few years, but the effect of comorbidities on outcomes of multiple sclerosis (MS) neurorehabilitation interventions is unclear. The aim of this review was to identify and summarize the existing evidence regarding the effect of comorbidities on outcomes of neurorehabilitation interventions targeting people with MS. Methods: Five databases (Embase, MEDLINE through Ovid, PubMed Central, Cumulative Index to Nursing and Allied Health Literature, and Web of Science) were searched using index terms and keywords relating to MS and a wide range of rehabilitation interventions...
November 2016: International Journal of MS Care
https://www.readbyqxmd.com/read/27999521/screening-tools-for-anxiety-in-people-with-multiple-sclerosis-a-systematic-review
#6
Brittany Litster, Kirsten M Fiest, Scott B Patten, John D Fisk, John R Walker, Lesley A Graff, James M Bolton, Jitender Sareen, James J Marriott, Lindsay I Berrigan, Charles N Bernstein, Ryan Zarychanski, Alexander Singer, Carol A Hitchon, Christine A Peschken, Ruth Ann Marrie
Background: Anxiety is prevalent in people with multiple sclerosis (MS). Screening measures are used to identify symptoms of anxiety, but the optimal measure to screen for anxiety disorders in MS has not been established. Methods: We searched the MEDLINE, Embase, PsycINFO, PsycARTICLES Full Text, Cumulative Index to Nursing and Allied Health Literature, Web of Science, and Scopus databases from database inception until August 7, 2015. Two independent reviewers screened abstracts and full-text reports for study inclusion, extracted data, and assessed risk of bias...
November 2016: International Journal of MS Care
https://www.readbyqxmd.com/read/27999520/comorbidity-in-multiple-sclerosis-some-answers-more-questions
#7
Ruth Ann Marrie
No abstract text is available yet for this article.
November 2016: International Journal of MS Care
https://www.readbyqxmd.com/read/27803643/editorial
#8
EDITORIAL
Francois Bethoux
No abstract text is available yet for this article.
September 2016: International Journal of MS Care
https://www.readbyqxmd.com/read/27803642/-cme-cne-article-severity-grading-in-multiple-sclerosis-a-proposal
#9
Robert Charlson, Joshua Herbert, Ilya Kister
Currently used classification schemes for multiple sclerosis (MS) have not taken into account disease severity, instead focusing on disease phenotype (ie, relapsing vs. progressive). In this article, we argue that disease severity adds a crucial dimension to the clinical picture and may help guide treatment decisions. We outline a practical, easy-to-implement, and comprehensive scheme for severity grading in MS put forward by our mentor, Professor Joseph Herbert. We believe that severity grading may help to better prognosticate individual disease course, formulate and test rational treatment algorithms, and enhance research efforts in MS...
September 2016: International Journal of MS Care
https://www.readbyqxmd.com/read/27803641/the-transition-to-secondary-progressive-multiple-sclerosis-an-exploratory-qualitative-study-of-health-professionals-experiences
#10
Freya Davies, Fiona Wood, Katherine E Brain, Michelle Edwards, Rhiannon Jones, Rachel Wallbank, Neil P Robertson, Adrian Edwards
Background: Identifying the transition from relapsing-remitting to secondary progressive multiple sclerosis (SPMS) can be challenging for clinicians. Little previous research has explored how professionals experience working with patients during this specific stage of the disease. We explored the experiences of a group of multidisciplinary professionals who support patients in the transition to SPMS to describe this stage from a professional perspective. Methods: This qualitative semistructured interview study included 11 professionals (medical, nursing, and allied health professionals; specialists and generalists) working with patients with MS in South Wales, United Kingdom...
September 2016: International Journal of MS Care
https://www.readbyqxmd.com/read/27803640/a-qualitative-study-of-multiple-health-behaviors-in-adults-with-multiple-sclerosis
#11
Matthew A Plow, Meghan Golding
Background: Evidence regarding inflammatory pathways, elevated cardiovascular risk, and negative effects of secondary conditions on disability progression provide a strong rationale for promoting multiple health behaviors in adults with multiple sclerosis (MS). However, many unanswered questions remain about the best ways to design multiple behavior change interventions for adults with MS. We sought to identify facilitators and barriers to engaging in multiple health behaviors (physical activity, nutrition, and sleep) and to gain further insights into how to develop multiple health behavior change interventions based on preferences of adults with MS...
September 2016: International Journal of MS Care
https://www.readbyqxmd.com/read/27803639/correction-of-footdrop-due-to-multiple-sclerosis-using-the-stimustep-implanted-dropped-foot-stimulator
#12
Paul N Taylor, Ingrid A Wilkinson Hart, Mansoor S Khan, Diana E M Slade-Sharman
Background: Footdrop is a significant problem in multiple sclerosis, reducing the safety and efficiency of walking. Functional electrical stimulation (FES) can produce dorsiflexion, correcting footdrop. The purpose of this retrospective analysis of clinical study data was to compare the effect of external and implanted FES devices for the correction of footdrop. Methods: External FES was used for a minimum of 6 months before implantation. Walking performance was assessed using 10-m walking speed, 3-minute walking distance, the Physiological Cost Index, and health- and device-related quality of life and device-use questionnaires...
September 2016: International Journal of MS Care
https://www.readbyqxmd.com/read/27803638/disability-progression-after-switching-from-natalizumab-to-fingolimod-or-interferon-beta-glatiramer-acetate-therapies-a-narcoms-analysis
#13
Stacey S Cofield, Robert J Fox, Tuula Tyry, Amber R Salter, Denise Campagnolo
Background: Physicians must weigh the benefits against the risk of progressive multifocal leukoencephalopathy (PML) in patients treated with natalizumab, especially beyond 2 years. However, disability progression associated with switching therapies versus continuing natalizumab therapy after 2 years has not been fully evaluated. Methods: In this retrospective analysis using the NARCOMS Registry, disability progression (Patient-Determined Disease Steps [PDDS] scale) and physical health-related quality of life (HRQOL) worsening (12-item Short Form Health Status Survey Physical Component Score [SF-12 PCS]) were compared between participants switching to fingolimod (n = 50) or interferon beta (IFNβ)/glatiramer acetate (GA) (n = 71) therapy and those continuing natalizumab (n = 406) after 2 years or more of treatment (median follow-up: natalizumab, 4 years; fingolimod, 4...
September 2016: International Journal of MS Care
https://www.readbyqxmd.com/read/27803637/exercise-training-in-progressive-multiple-sclerosis-a-comparison-of-recumbent-stepping-and-body-weight-supported-treadmill-training
#14
Lara A Pilutti, John E Paulseth, Carin Dove, Shucui Jiang, Michel P Rathbone, Audrey L Hicks
Background: There is evidence of the benefits of exercise training in multiple sclerosis (MS); however, few studies have been conducted in individuals with progressive MS and severe mobility impairment. A potential exercise rehabilitation approach is total-body recumbent stepper training (TBRST). We evaluated the safety and participant-reported experience of TBRST in people with progressive MS and compared the efficacy of TBRST with that of body weight-supported treadmill training (BWSTT) on outcomes of function, fatigue, and health-related quality of life (HRQOL)...
September 2016: International Journal of MS Care
https://www.readbyqxmd.com/read/27803636/letter-to-the-editor-the-emerging-role-of-pharmacists-in-the-multidisciplinary-care-of-patients-with-multiple-sclerosis
#15
Jordan Schultz, Cindy Weber, John Kamholz
No abstract text is available yet for this article.
September 2016: International Journal of MS Care
https://www.readbyqxmd.com/read/27551247/editorial
#16
Francois Bethoux
No abstract text is available yet for this article.
July 2016: International Journal of MS Care
https://www.readbyqxmd.com/read/27551246/management-strategies-for-flu-like-symptoms-and-injection-site-reactions-associated-with-peginterferon-beta-1a-obtaining-recommendations-using-the-delphi-technique
#17
June Halper, Diego Centonze, Scott D Newsome, DeRen Huang, Christopher Robertson, Xiaojun You, Guido Sabatella, Vladimir Evilevitch, Leslie Leahy
BACKGROUND: Flu-like symptoms (FLSs) and injection-site reactions (ISRs) have been reported with interferon beta treatments for multiple sclerosis (MS). We sought to obtain consensus on the characteristics/management of FLSs/ISRs in patients with relapsing-remitting MS based on experiences from the randomized, placebo-controlled ADVANCE study of peginterferon beta-1a. METHODS: ADVANCE investigators with a predefined number of enrolled patients were eligible to participate in a consensus-generating exercise using a modified Delphi method...
July 2016: International Journal of MS Care
https://www.readbyqxmd.com/read/27551245/assessing-four-quality-indicators-for-multiple-sclerosis-management-through-patient-reported-data
#18
Sarah J Shoemaker, Alyssa Pozniak, Louise Hadden
BACKGROUND: Although hundreds of quality indicators (QIs) have been developed for various chronic conditions, QIs specific to multiple sclerosis (MS) care have only recently been developed. We sought to examine the extent to which the self-reported care of individuals with MS meets four recently developed MS QIs related to treatment of depression, spasticity, and fatigue and timely initiation of disease-modifying agents (DMAs) for relapsing MS. METHODS: Using the Sonya Slifka Study data, we examined the proportion of the MS population meeting four QIs (based on patient-reported data) in a sample of individuals with MS in 2007-2009...
July 2016: International Journal of MS Care
https://www.readbyqxmd.com/read/27551244/coping-with-multiple-sclerosis-scale-reconsideration-of-the-factorial-structure
#19
Holly A Parkerson, Melissa D Kehler, Donald Sharpe, Heather D Hadjistavropoulos
BACKGROUND: The Coping with Multiple Sclerosis Scale (CMSS) was developed to assess coping strategies specific to multiple sclerosis (MS). Despite its wide application in MS research, psychometric support for the CMSS remains limited to the initial factor analytic investigation by Pakenham in 2001. METHODS: The current investigation assessed the factor structure and construct validity of the CMSS. Participants with MS (N = 453) completed the CMSS, as well as measures of disability related to MS (Multiple Sclerosis Impact Scale), quality of life (World Health Organization Quality of Life Brief Scale), and anxiety and depression (Hospital Anxiety and Depression Scale)...
July 2016: International Journal of MS Care
https://www.readbyqxmd.com/read/27551243/the-perceived-deficits-questionnaire-perception-deficit-or-distress
#20
Lauren B Strober, Allison Binder, Olga M Nikelshpur, Nancy Chiaravalloti, John DeLuca
BACKGROUND: Cognitive dysfunction affects approximately 43% to 70% of individuals with multiple sclerosis (MS) and is an important determinant of several functional outcomes in MS and quality of life. Brief neuropsychological test batteries have been developed specifically for use in MS and are widely used to aid clinicians in assessing levels of cognitive impairment in MS. Neuropsychologists and neurologists also frequently use briefer screening measures, such as the Perceived Deficits Questionnaire (PDQ), to assist in determining whether a more extensive neuropsychological evaluation is warranted...
July 2016: International Journal of MS Care
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