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Journal of Cosmetic Dermatology

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https://www.readbyqxmd.com/read/28447433/serum-vitamin-d-level-is-related-to-disease-severity-in-pediatric-alopecia-areata
#1
Mehmet Unal, Gulsum Gonulalan
BACKGROUND: Alopecia areata (AA) is the most common cause of inflammatory hair loss. AA is considered an autoimmune disease and occurs with various autoimmune disorders. Recent studies have revealed connection between autoimmune diseases and vitamin D deficiency. OBJECTIVES: In this study, we investigated vitamin D status in AA and its relationship with disease severity, number of patches, and disease duration. METHODS: This study included 20 pediatric patients with AA and 34 pediatric healthy controls...
April 26, 2017: Journal of Cosmetic Dermatology
https://www.readbyqxmd.com/read/28432727/efficacy-of-fractionated-microneedle-radiofrequency-with-and-without-adding-subcision-for-the-treatment-of-atrophic-facial-acne-scars-a-randomized-split-face-clinical-study
#2
Gita Faghihi, Nazila Poostiyan, Ali Asilian, Bahareh Abtahi-Naeini, Masoom Shahbazi, Fariba Iraji, Farahnaz Fatemi Naeini, Mohammad Ali Nilforoushzadeh
BACKGROUND: There is no gold standard treatment for facial acne scars, and overall, little literature exists about the combination therapy for treatment of acne scar. AIMS: The aim of this study was to evaluate the efficacy of fractionated microneedle radiofrequency (FMR) vs FMR combined with subcision for the treatment of atrophic acne scars. PATIENTS/METHODS: This was a randomized, split-face clinical study of 25 patients with II-IV Fitzpatrick skin types with moderate to severe facial atrophic acne scars...
April 22, 2017: Journal of Cosmetic Dermatology
https://www.readbyqxmd.com/read/28432719/effect-of-ficus-carica-leaf-extract-on-the-gene-expression-of-selected-factors-in-hacat-cells
#3
Murat Turkoglu, Erkin Pekmezci, Songul Kilic, Cihat Dundar, Hakan Sevinc
BACKGROUND: Ficus carica Linn. (Fc), common fig, has been traditionally used for many metabolic, cardiovasculary, respiratory, gastrointestinal, and skin disorders. Several studies were performed showing its anti-inflammatory, anti-angiogenic, anticancerogenic, and tissue-protective effects. In all of those studies, the positive effects of Fc were concluded as the result of its antioxidant and anti-inflammatory features due to the polyphenols it contains. AIMS: To study the phenolic compounds of Fc extract and to investigate the molecular basis of anti-inflammatory, anti-angiogenic, antimitotic, and anti-androgenic effects of Fc leaf extract in vitro...
April 22, 2017: Journal of Cosmetic Dermatology
https://www.readbyqxmd.com/read/28429841/the-development-evidence-and-current-use-of-atx-101-for-the-treatment-of-submental-fat
#4
REVIEW
Corey Georgesen, Shari R Lipner
ATX-101 (deoxycholic acid) is the first pharmaceutical therapy approved by the FDA for the reduction in submental fat. Deoxycholic acid is an endogenous secondary bile acid that normally solubilizes dietary fat, contributing to its breakdown and absorption within the gut. This article reviews the identification of deoxycholic acid as a lipolytic agent, and the mechanism of action, pharmacokinetics, and pharmacodynamics of ATX-101. In addition to phase I/II trials, four Phase III clinical trials have evaluated safety and efficacy of ATX-101...
April 21, 2017: Journal of Cosmetic Dermatology
https://www.readbyqxmd.com/read/28421656/oral-intake-of-boesenbergia-pandurata-extract-improves-skin-hydration-gloss-and-wrinkling-a-randomized-double-blind-and-placebo-controlled-study
#5
Do Un Kim, Hee Chul Chung, Changhee Kim, Jae-Kwan Hwang
BACKGROUND: Photoaging is a severe skin damage that occurs as a result of exposure to external elements, primarily ultraviolet (UV) irradiation. Chronically, UV-irradiated skin exhibits the signs of sunburn and hyperpigmentation with the destruction of connective tissues. Previously, Boesenbergia pandurata (B. pandurata) and its active compound panduratin A showed antiphotoaging activities in vitro and in vivo. OBJECTIVE: The aim of this study was to investigate the clinical efficacy of B...
April 18, 2017: Journal of Cosmetic Dermatology
https://www.readbyqxmd.com/read/28382785/autologous-platelet-rich-plasma-versus-readymade-growth-factors-in-skin-rejuvenation-a-split-face-study
#6
Heba I Gawdat, Amira M Tawdy, Rehab A Hegazy, Mohga M Zakaria, Ryham S Allam
BACKGROUND: The escalating urge for a youthful-looking skin instigates continuous innovations with minimally invasive procedures. Readymade growth factors and autologous platelet-rich plasma (PRP) represent such therapeutic interventions. OBJECTIVE: Compare the efficacy and safety of PRP to readymade growth factors in skin rejuvenation. PATIENTS AND METHODS: Twenty adult females with Fitzpatrick skin types III-IV and Glogau photoaging types II and III were enrolled in this study...
April 5, 2017: Journal of Cosmetic Dermatology
https://www.readbyqxmd.com/read/28382655/effectiveness-of-topical-clove-oil-on-symptomatic-treatment-of-chronic-pruritus
#7
Ibrahim M Ibrahim, Mohamed L Elsaie, Abdelraouf M Almohsen, Mahmoud H Mohey-Eddin
BACKGROUND: Pruritus is a frequent symptom in the general population and in many skin and systemic diseases. Its frequency demonstrates a high burden and an impaired quality of life. AIM: Assessment of the efficacy of topically applied clove oil alone in the treatment of chronic pruritus. METHODS: Fifty selected subjects diagnosed with chronic pruritus due to either hepatic, renal, or diabetic causes were studied and divided into two groups of 25 patients each...
April 5, 2017: Journal of Cosmetic Dermatology
https://www.readbyqxmd.com/read/28374517/striae-distensae-immunohistochemical-assessment-of-hormone-receptors-in-multigravida-and-nulligravida
#8
Sahar El Sayed Youssef, Ekramy Ahmed El-Khateeb, Dalia Gamal Aly, Manal Hassan Moussa
BACKGROUND: Striae distensae (SD), a type of dermal scarring, are psychologically disappointing. To date, information and scientific research behind the role of hormonal factors in the development of SD are still unclear. It is vital to understand striae to offer patients the best therapeutic options. OBJECTIVES: To investigate early alterations regarding the expression of estrogen, androgen, and glucocorticoid receptors (estrogen receptor (ER), androgen receptor (AR), glucocorticoid receptor (GR) in skin samples of multigravida (MG) and nulligravida (NG) cases and to compare them with normal controls...
April 4, 2017: Journal of Cosmetic Dermatology
https://www.readbyqxmd.com/read/28371204/a-randomized-single-blinded-trial-of-a-tripeptide-hexapeptide-healing-regimen-following-laser-resurfacing-of-the-face
#9
Monique J Vanaman Wilson, Joanna Bolton, Sabrina Guillen Fabi
BACKGROUND: A topical healing system containing a combination of active ingredients including a tripeptide and hexapeptide (TriHex Technology™) has been found to stimulate neoelastogenesis and neocollagenesis. OBJECTIVE: Evaluate the use of the tripeptide/hexapeptide topical system following fractionated CO2 laser resurfacing compared to a bland ointment and cream. PATIENTS/METHODS: In this single-blinded, randomized study, 15 female subjects aged 45-70 years underwent laser resurfacing of the face...
March 31, 2017: Journal of Cosmetic Dermatology
https://www.readbyqxmd.com/read/28371078/efficacy-of-an-emollient-containing-diethylene-glycol-dilinoleic-acid-copolymer-for-the-treatment-of-dry-skin-and-pruritus-in-patients-with-senile-xerosis
#10
Runa Izumi, Osamu Negi, Tamie Suzuki, Mitsutoshi Tominaga, Atsuko Kamo, Yasushi Suga, Shoko Matsukuma, Kenji Takamori
BACKGROUND AND AIMS: Pruritus frequently reduces quality of life (QOL) in patients with senile xerosis. This study investigated the moisturizing and antipruritic effects of a topical emollient containing a diethylene glycol/dilinoleic acid copolymer (D/DC) in patients with pruritic senile xerosis. METHODS: This single-blind study involved 50 subjects, aged 50-75 years. Patients were randomized to self-applied treatment of the lower legs with 10% (n = 20) or 20% (n = 20) D/DC-containing cream, white petrolatum (n = 5), or no treatment (n = 5) thrice daily for four weeks...
March 30, 2017: Journal of Cosmetic Dermatology
https://www.readbyqxmd.com/read/28370943/hypochlorous-acid-gel-technology-its-impact-on-postprocedure-treatment-and-scar-prevention
#11
REVIEW
Michael H Gold, Anneke Andriessen, Steven H Dayan, Sabrina G Fabi, Z Paul Lorenc, Meagan-Helen Henderson Berg
BACKGROUND: A pre-and postprocedure regime aimed at prevention of infection, reduction of inflammation and risk of scarring, is to enable optimal outcomes. OBJECTIVES: The role of a hypochlorous acid containing spray and translucent scar gel formulation that combines modified silicon oil with hypochlorous acid, was explored for pre- and postprocedure treatment and scar management. METHODS: For this purpose a literature review was conducted to explore the value of the technology used in pre-and postprocedural regimes...
March 30, 2017: Journal of Cosmetic Dermatology
https://www.readbyqxmd.com/read/28349655/review-in-peeling-complications
#12
REVIEW
Izelda Maria Carvalho Costa, Patrick Silva Damasceno, Mariana Carvalho Costa, Keila Gabrielle Pati Gomes
Chemical peeling, a procedure wherein a chemical agent is applied to the skin to cause controlled destruction followed by regeneration and remodeling, is a dynamic tool for the treatment of acne, pigmentation issues, and photoaging [Journal of cutaneous and aesthetic surgery vol. 5 (2012) 254-260]. The results and complications are related to the depth of the procedure, with deeper peels producing more marked results and higher rates of complications. Complications are more likely with darker skin types, certain peeling agents, and sun exposure after treatment [Journal of cutaneous and aesthetic surgery vol...
March 27, 2017: Journal of Cosmetic Dermatology
https://www.readbyqxmd.com/read/28349651/dermasence-refining-gel-modulates-pathogenetic-factors-of-rosacea-in-vitro
#13
C Borelli, B Becker, S Thude, B Fehrenbacher, D Isermann
BACKGROUND: Over the counter cosmetics sold for local treatment of slight to moderate rosacea often state the claim of actively modulating rosacea pathogenesis. Factors involved in the pathogenesis of this common yet complex skin disorder include kallikrein-related peptidase 5 (KLK5), LL-37, as well as protease-activated receptor 2 (PAR2) and vascular endothelial growth factor (VEGF). OBJECTIVE: The objective was to prove the modulating effect of the cosmetic skin care agent Dermasence Refining Gel (DRG) on factors involved in rosacea pathogenesis...
March 27, 2017: Journal of Cosmetic Dermatology
https://www.readbyqxmd.com/read/28342238/a-peel-off-facial-mask-comprising-myoinositol-and-trehalose-loaded-liposomes-improves-adult-female-acne-by-reducing-local-hyperandrogenism-and-activating-autophagy
#14
Gabriella Fabbrocini, Claudia Capasso, Marianna Donnarumma, Mariateresa Cantelli, Michel Le Maître, Giuseppe Monfrecola, Enzo Emanuele
BACKGROUND: Hyperandrogenism and reduced skin autophagy have been implicated in the pathogenesis of adult female acne (AFA). Here, we tested whether a ready-to-use peel-off facial mask containing myoinositol (an androgen inhibitor) and trehalose-loaded liposomes (as activators of cutaneous autophagy) applied overnight every other day for 60 days can improve AFA. We also sought to investigate the molecular mechanisms underlying the clinical effects. OBJECTIVES: We conducted an uncontrolled, open-label clinical study in 40 cases of AFA to investigate the effect of the facial mask on lesion count, sebum production (measured with the Sebutape® technique), and Global Acne Grading System (GAGS) scale...
March 25, 2017: Journal of Cosmetic Dermatology
https://www.readbyqxmd.com/read/28342199/overexpression-of-drosha-digeorge-syndrome-critical-region-gene-8-dgcr8-and-dicer-mrnas-in-the-pathogenesis-of-psoriasis
#15
Majid Rostami Mogaddam, Nastaran Safavi Ardabili, Yousef Shafaeei, Nasrollah Maleki, Naser Jafari, Alireza Jafari
INTRODUCTION: Psoriasis is a complex autoimmune inflammatory disease that occurs in genetically susceptible individuals and presents with the development of inflammatory plaques on the skin. Recent studies have indicated that microRNAs (miRNAs) play important roles in psoriasis. OBJECTIVE: To investigate whether expression of Drosha, DGCR8, and Dicer mRNAs is involved in the pathogenesis of psoriasis. METHODS: Biopsies were obtained from involved psoriatic skin (PP), noninvolved psoriatic skin (PN), and healthy skin (NN)...
March 25, 2017: Journal of Cosmetic Dermatology
https://www.readbyqxmd.com/read/28333405/use-of-nanofractional-radiofrequency-for-the-treatment-of-acne-scars-in-indian-skin
#16
Apratim Goel, Vallari Gatne
BACKGROUND: Pitted acne scars of all types remain notoriously challenging to treat with no satisfactory treatment modality, particularly true for darker Fitzpatrick skin types such as Indian skin. AIM: Nanofractional radiofrequency has been shown to be an effective treatment modality for the cosmetic improvement of acne scars. METHODS: Twenty healthy male and female Indian patients aged 16-60 years with Fitzpatrick skin types IV-V and moderate-to-severe acne scar lesions received 1-3 treatments with a nanofractional radiofrequency device (Venus Viva) at baseline and at 3- to 6 week intervals and were evaluated with photographs at each treatment visit and up to 6 months after the final treatment session...
March 23, 2017: Journal of Cosmetic Dermatology
https://www.readbyqxmd.com/read/28317240/treatment-of-nevus-lipomatosus-cutaneous-superficialis-with-co2-laser
#17
Kabir Sardana, Shivani Bansal, Vijay K Garg, Nita Khurana
Nevus lipomatosus cutaneous superficialis (NLCS) is an uncommon lesion characterized by ectopic adipose tissue in the dermis and can be generalized or localized. It presents as a soft skin colored to yellowish papules or cerebriform plaques occurring usually on the buttock or thigh in a segment distribution. We report a case of NLCS in 38-year-old female, which was treated using the ultrapulse mode CO2 Laser. We describe the scientific logic and clinical results of using the ultrapulse mode in relation to the pathology of NLCS...
March 19, 2017: Journal of Cosmetic Dermatology
https://www.readbyqxmd.com/read/28294535/comparative-study-of-autologous-fat-vs-hyaluronic-acid-in-correction-of-the-nasolabial-folds
#18
Xiaogen Hu, Zhiqiang Xue, Huijie Qi, Bo Chen
OBJECTIVE: In the article, comparison of the hyaluronic acid (HA) and autologous fat is conducted to evaluate the effectiveness and safety in correction of the nasolabial folds (NLFs). METHODS: From November 2012 to December 2015, a single-blinded, randomized study was conducted. Sixty-two patients were included in the study, and 57 of them completed the whole procedure. The patients were randomly allocated to receive the treatments of HA or fat in both NLFs. The Wrinkle Severity Rating Scale (WSRS) and Global Aesthetic Improvement Scale (GAIS) were used for assessment...
March 14, 2017: Journal of Cosmetic Dermatology
https://www.readbyqxmd.com/read/28296142/platelet-rich-plasma-for-androgenetic-alopecia-does-it-work-evidence-from-meta-analysis
#19
REVIEW
Salvatore Giordano, Marco Romeo, Petteri Lankinen
INTRODUCTION: The use of platelet-rich plasma (PRP) has increased among different surgical specialities for the treatment of various conditions. Androgenetic alopecia is a common condition, with severe attendant psychosocial implications. PRP injections for hair restoration have become a popular practice among plastic surgeons. We performed a meta-analysis comparing local injection of platelet-rich plasma versus control to evaluate this issue in order to investigate the effectiveness of PRP local injections for androgenetic alopecia...
March 13, 2017: Journal of Cosmetic Dermatology
https://www.readbyqxmd.com/read/28276195/nodular-colloid-milium-mimicking-keloid
#20
Seyyede Zeinab Azimi, Omid Zargari, Robert I Rudolph
Colloid milium is a rare cutaneous deposit disease that usually presents clinically by the development of yellowish translucent or flesh-colored papules or plaques on sun-exposed skin. Histologically, it is characterized by the presence of colloid in the dermal papillae. In this case report, we present a 52-year-old man who presented with a nodule on his upper lip that mistakenly was diagnosed and treated as keloid.
March 9, 2017: Journal of Cosmetic Dermatology
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